What are the forms of amyloidosis? There are different forms of amyloidosis, distinguished by the type of proteins that make up the amyloid fibrils:

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "What are the forms of amyloidosis? There are different forms of amyloidosis, distinguished by the type of proteins that make up the amyloid fibrils:"

Transcription

1 Amyloidosis What is amyloidosis? Amyloidosis is characterized by deposition of abnormally aggregated or clumped proteins between cells that make up an organ. These aggregates or protein clumps are called amyloid fibrils. They can be deposited in only one organ, such as the skin, urogenital-, or respiratory tract, or more widespread in the body and then most often impair the function of one or more of the following organs: Kidneys, heart, liver, GI tract, and peripheral nerves. What are the forms of amyloidosis? There are different forms of amyloidosis, distinguished by the type of proteins that make up the amyloid fibrils: AL (amyloid light chain) amyloidosis. Previously this was called primary amyloidosis. The deposited proteins, called light chains, are a building block of antibodies and produced by abnormally growing and / or surviving immune cells. Sometimes these cells cause additional problems and are then considered cancerous. The cancer most frequently caused by these cells is called multiple myeloma, which is further explained in a separate document. Senile or age related amyloidosis. Here, a normal blood protein, usually a protein called transthyretin, is abnormally deposited in tissues for unknown reasons. Most often it is diagnosed when these proteins are deposited in the heart, but other organs can be involved as well. Familial or hereditary amyloidosis. There are several genetic changes or mutations known that result in the production of blood proteins with altered chemical properties leading to their aggregation and deposition in tissues. The most commonly affected protein is again transthyretin. Inflammatory amyloidosis. This was previously called secondary amyloidosis because it is a secondary problem of chronic inflammatory processes. Crohn s disease, rheumatoid arthritis, chronic infections and other inflammatory states go together with production of inflammatory proteins that float in the blood and in rare cases are deposited as amyloid in tissues. Hemodialysis related amyloidosis. This is caused by deposition of a blood protein called beta-2 microglobulin. The kidneys are the only organs that can get rid of this protein and with end stage kidney disease very high levels can be seen, that over time (usually over more than 5 years) can lead to amyloidosis. In recent years this type of amyloidosis is decreasing in incidence with improvement of dialysis techniques that help keep the beta-2 microglobulin concentration lower. What causes amyloidosis? The cause for genetic or hereditary amyloidosis is a heritable genetic alteration. For the other types of amyloidosis it is not clear why some people develop the disease whereas the majority of individuals do not, even if they share the underlying condition. Is amyloidosis a form of cancer? Generally amyloidosis is not considered cancer but light chain amyloidosis can go together with cancers of immune cells that produce antibodies or pieces thereof in an unregulated fashion.

2 What are the signs and symptoms of amyloidosis? Symptoms of amyloidosis usually develop long after amyloid starts being deposited. In addition symptoms are not specific, often leading to a delay in diagnosis. Commonly seen symptoms include the following. Any symptom can occur alone or in combination. Weakness or fatigue Weight loss Symptoms related to deposition in the heart - Shortness of breath, sometimes with cough and / or chest pressure - Swelling of the feet and legs (edema) - Irregular heart rhythm - Lightheadedness or even passing out due to low blood pressure Symptoms related to deposition in the kidneys (they usually first become leaky for proteins, leading to loss of the blood protein albumin. Albumin is needed to keep fluid in the blood vessels. Later the clearance of metabolic waste products from the blood can be impaired.) - Swelling of the legs (edema), abdomen (ascites), and, in the morning, of the eyelids - Shortness of breath - Decreased energy level - Anemia (low hemoglobin level) Symptoms related to deposition in or around the peripheral nerves or the nerves that innervate the heart, blood vessels, and gastro-intestinal tract - Abnormal sensations (tingling, sometimes pain) or numbness in the extremities - Lightheadedness or even passing out upon rising from bed or chair - Nausea, vomiting - Bloating, diarrhea, constipation Symptoms related to deposition in the gastro-intestinal tract - Enlarged tongue - Difficulty swallowing - Nausea and vomiting - Diarrhea or constipation - Bleeding (tar-like stool, red stool, or vomiting of coffee-ground-like material) Symptoms related to deposition in the liver - Early satiety - Abdominal swelling (from large liver or fluid accumulation) - Tendency to bleed - Altered mental state (extreme fatigue, confusion) Skin changes (easy bruising especially around the eyes, non-itchy rash, unusual sores or bumps, or thickening of the skin) Symptoms related to deposition in or around the lungs (uncommon) - Cough - Shortness of breath

3 Changes in vision (caused by amyloid deposits behind the lens of the eye) Nail changes Unusual hair loss Swelling of the lymph glands (uncommon) Symptoms related to deposition in the genitor-urinary tract (may be seen in localized amyloidosis) - Blood in the urine - Difficulty voiding - Burning on urination - Pain or dysfunction with sexual intercourse How common is amyloidosis? Amyloidosis is a rare disease, with an estimated incidence of around 10 cases per 1 million person-years. Among the diagnosed cases senile amyloid appears to be followed by light chain amyloid in the most recent reports (formerly light chain amyloid was felt to be the most common form). The other types of amyloid are even rarer. Amyloidosis is usually diagnosed later in life but especially genetic amyloidosis can also lead to symptoms in younger individuals. How is amyloidosis diagnosed? The diagnosis of amyloidosis requires confirmation of amyloid deposits through biopsy and analysis of the protein that is being deposited. Since the symptoms are not specific and the disease is a rare one, it is not uncommon that the diagnosis is delayed for several months, sometimes years, after the symptoms are first brought to medical attention. What additional tests are needed? In light chain amyloidosis, additional blood and urine tests are required and a bone marrow biopsy as well as x-rays of the bones are necessary to rule out multiple myeloma. Screening tests to determine which organs are involved include blood tests, a 24 hour urine collection and an ECG. Organs felt to be involved based on symptoms and screening tests may need further tests like an ultrasound of the heart or the liver, sometimes and endoscopic examination of the gastro-intestinal tract, or a CT of the chest to evaluate the lungs. Consultation with specialists for the respective involved organs help optimize care further. How is amyloidosis treated? This depends on the type. Localized amyloidosis is treated with local measures, usually resection with laser beams. The more common systemic forms are treated differently depending on the amyloid type. This can sometimes cure the disease, sometimes repeated procedures are necessary. The treatment of light chain amyloidosis is based on treatment of the cells that produce the deposited light chains. This can be done with cortisone-like steroids, new drugs effective in myeloma as well, and chemo, low-dose as outpatient or very high dose inpatient followed by a rescue from associated bone marrow depletion with stem cells that are collected from the blood prior. All these measures can not cure the underlying disease but can suffice to significantly reduce or abrogate the light chain production and thus prevent worsening or deposition in additional organs in the majority of patients for

4 varying periods of time. Once the light chain production is well controlled it usually remains controlled for months to years. When it comes back an alternative treatment regimen often controls it again. The organ function of involved organs can improve also over many months but this can not be guaranteed, since it happens in only in about 30% of patients. It is dependent on the severity of involvement, the more advanced the organ damage, the more likely scarring has occurred, which is irreversible. Additionally this is dependent on the involved organ, the kidney and liver, if not severely involved have relatively good chances for recovery, in some studies up to 50%. Senile amyloidosis currently is treated predominantly symptomatically; usually this means drugs that are given for heart failure. A treatment of its cause is not possible but clinical trials are underway that test the ability of drugs to inhibit deposition of transthyretin, the protein that makes up amyloid fibrils in patients with this disease. Genetic or hereditary amyloidosis. In most cases the genetically abnormal protein that is deposited as amyloid in this disease is produced in the liver. Liver transplantation in patients who are felt fit enough for the procedure, is curative but does not undo irreversible organ damage. Patients without donor or not fit enough for liver transplantation may have an option for medical treatment in the future. At least in patients with a specific genetic alteration of transthyretin, a drug called tafamidis was able to reduce the progression of nerve damage compared to placebo. The proposed mechanism of this drug is stabilization and thus prevention of deposition of abnormal transthyretin. The drug is not FDA approved as of January 11, 2010 but could gain approval Inflammatory amyloidosis. Here the basic principle is that the inflammatory state should be treated to reduce the levels of inflammatory proteins and thus halt or reduce further deposition. With chronic infections the treatment consists of the appropriate antibiotics, but in the developed world auto-immune processes like Crohn s disease or other inflammatory states of unknown etiology are more common causes of this type of amyloid and require effective treatment with drugs that reduce inflammation. Inhibitors of the inflammatory protein tumor necrosis factor alpha have shown success in a variety of inflammatory amyloidoses, but sometimes drugs with fewer side effects like low doses of the gout medication colchicine can also be helpful. Just like in the other types of amyloidosis the main goal is to prevent progression. Existing organ damage requires symptomatic treatment, sometimes this means hemodialysis. Hemodialysis related amyloidosis. The main goal here is prevention and with the use of modern dialysis techniques and filters that help keep the beta-2 microglobulin concentration in the blood lower, this type of amyloidosis becomes rarer. In otherwise fit patients kidney transplantation can be helpful to prevent any worsening since it helps getting beta-2 microglobulin levels close to normal. What is the prognosis? Localized amyloidosis usually does not affect life expectancy but sometimes repeated procedures are necessary. Systemic amyloidosis is a chronic disease and usually progresses slowly over a number of years. The severity of the disease

5 depends on which organs are affected and how severely they are affected. It can be lifethreatening in severe cases and in other cases may not affect life expectancy if it is detected early enough and caused by an amyloid type that can be treated. Resources For more information or to schedule an appointment, please call: Debbie Hastings at The Amyloidosis Support Network and Amyloidosis Foundation supports patient education and research. You can visit their website at: The International Myeloma Foundation maintains a hotline for patients and others who need information about myeloma, its treatment and management. The hotline number is:

Multiple Myeloma. This reference summary will help you understand multiple myeloma and its treatment options.

Multiple Myeloma. This reference summary will help you understand multiple myeloma and its treatment options. Multiple Myeloma Introduction Multiple myeloma is a type of cancer that affects white blood cells. Each year, thousands of people find out that they have multiple myeloma. This reference summary will help

More information

RITUXIMAB (Rituxan) Rituximab 2007 Page 1 of 5

RITUXIMAB (Rituxan) Rituximab 2007 Page 1 of 5 RITUXIMAB (Rituxan) Rituximab is FDA approved for the treatment of low-grade or follicular CD20-positive, B-cell non-hodgkin's lymphoma (NHL); treatment of diffuse large B-cell CD20-positive NHL; treatment

More information

Myositis and Your Lungs

Myositis and Your Lungs Myositis and Your Lungs 2011 TMA Annual Meeting Las Vegas, Nevada Chester V. Oddis, MD University of Pittsburgh Myositis Heterogeneous group of autoimmune syndromes characterized by chronic muscle weakness

More information

Sarcoidosis. Exceptional healthcare, personally delivered

Sarcoidosis. Exceptional healthcare, personally delivered Sarcoidosis Exceptional healthcare, personally delivered The Bristol Interstitial Lung Disease Service at North Bristol NHS Trust cares for a catchment area of around 550,000 people (plus additional referrals

More information

Metabolic Disorders , The Patient Education Institute, Inc. idg90101 Last reviewed: 08/14/2014 1

Metabolic Disorders , The Patient Education Institute, Inc.  idg90101 Last reviewed: 08/14/2014 1 Metabolic Disorders Introduction Metabolism is the process your body uses to make energy from the food you eat. Your body can use this fuel right away, or it can store the energy in your body tissues,

More information

Other Noninfectious Diseases. Chapter 31 Lesson 3

Other Noninfectious Diseases. Chapter 31 Lesson 3 Other Noninfectious Diseases Chapter 31 Lesson 3 Diabetes Diabetes- a chronic disease that affects the way body cells convert food into energy. Diabetes is the seventh leading cause of death by disease

More information

calendar Your treatment for VELCADE (bortezomib) For the treatment of patients with multiple myeloma

calendar Your treatment for VELCADE (bortezomib) For the treatment of patients with multiple myeloma For the treatment of patients with multiple myeloma Your treatment calendar for VELCADE (bortezomib) VELCADE (bortezomib) is approved for the treatment of patients with multiple myeloma (a cancer of the

More information

Keeping track of your numbers

Keeping track of your numbers Keeping track of your numbers If you have relapsed or refractory multiple myeloma, keeping track of your numbers can help you take an active role in your care. It s also one way you and your doctor can

More information

Thymus Cancer. This reference summary will help you better understand what thymus cancer is and what treatment options are available.

Thymus Cancer. This reference summary will help you better understand what thymus cancer is and what treatment options are available. Thymus Cancer Introduction Thymus cancer is a rare cancer. It starts in the small organ that lies in the upper chest under the breastbone. The thymus makes white blood cells that protect the body against

More information

Bone Marrow or Blood Stem Cell Transplants in Children With Severe Forms of Autoimmune Disorders or Certain Types of Cancer

Bone Marrow or Blood Stem Cell Transplants in Children With Severe Forms of Autoimmune Disorders or Certain Types of Cancer Bone Marrow or Blood Stem Cell Transplants in Children With Severe Forms of Autoimmune Disorders or Certain Types of Cancer A Review of the Research for Parents and Caregivers Is This Information Right

More information

Liver Cancer What is the liver? What is liver cancer?

Liver Cancer What is the liver? What is liver cancer? Liver Cancer What is the liver? The liver is the largest internal organ in the body and is important in digesting food. The liver performs many other functions, including collecting and filtering blood

More information

Multiple Myeloma Understanding your diagnosis

Multiple Myeloma Understanding your diagnosis Multiple Myeloma Understanding your diagnosis Multiple Myeloma Understanding your diagnosis When you first hear that you have cancer you may feel alone and afraid. You may be overwhelmed by the large amount

More information

Multiple Myeloma. Understanding your diagnosis

Multiple Myeloma. Understanding your diagnosis Multiple Myeloma Understanding your diagnosis Multiple Myeloma Understanding your diagnosis When you first hear that you have cancer, you may feel alone and afraid. You may be overwhelmed by the large

More information

Heart disorders (acquired) - children

Heart disorders (acquired) - children Heart disorders (acquired) - children Summary An acquired heart defect develops in children after a disease. There are four types of acquired heart defect. All children with heart defects have special

More information

WARNING, CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS,

WARNING, CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, FACT SHEET BRANDED/GENERIC NAME: ABRAXANE for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) ABRAXANE is an albumin-bound form of paclitaxel with a

More information

Autoimmune Hepatitis

Autoimmune Hepatitis Autoimmune Hepatitis National Digestive Diseases Information Clearinghouse U.S. Department of Health and Human Services NATIONAL INSTITUTES OF HEALTH What is autoimmune hepatitis? Autoimmune hepatitis

More information

Breast Cancer. Breast Cancer Page 1

Breast Cancer. Breast Cancer Page 1 Breast Cancer Summary Breast cancers which are detected early are curable by local treatments. The initial surgery will give the most information about the cancer; such as size or whether the glands (or

More information

SARCOIDOSIS. Signs and symptoms associated with specific organ involvement can include the following:

SARCOIDOSIS. Signs and symptoms associated with specific organ involvement can include the following: SARCOIDOSIS Sarcoidosis is a disease characterized by the presence of granulomas. Ball-like collections of white blood cells, granulomas may be associated with inflammation. The inflammation can damage

More information

QUESTIONS TO ASK MY DOCTOR

QUESTIONS TO ASK MY DOCTOR Be a part of the treatment decision by asking questions QUESTIONS TO ASK MY DOCTOR FOR PATIENTS WITH ADVANCED STOMACH OR GASTROESOPHAGEAL JUNCTION (GEJ) CANCER CYRAMZA (ramucirumab) is used alone or in

More information

LYMPHOMA IN DOGS. Diagnosis/Initial evaluation. Treatment and Prognosis

LYMPHOMA IN DOGS. Diagnosis/Initial evaluation. Treatment and Prognosis LYMPHOMA IN DOGS Lymphoma is a relatively common cancer in dogs. It is a cancer of lymphocytes (a type of white blood cell) and lymphoid tissues. Lymphoid tissue is normally present in many places in the

More information

Infliximab is used to treat psoriasis, psoriatic arthritis, and several other inflammatory conditions, including other inflammatory skin diseases.

Infliximab is used to treat psoriasis, psoriatic arthritis, and several other inflammatory conditions, including other inflammatory skin diseases. INFLIXIMAB What are the aims of this leaflet? This leaflet has been written to help you understand more about the medication infliximab. It tells you what it is, how it works, how it is used to treat skin

More information

Sepsis: What You Should Know

Sepsis: What You Should Know Issues & Answers Sepsis: What You Should Know Answers to your questions about what it is and how it is treated in the ICU. 2003 SCCM Your doctor or the intensivist (a doctor with special expertise and

More information

Symptoms of non-hodgkin lymphoma

Symptoms of non-hodgkin lymphoma Produced 28.02.2011 Revision due 28.02.2013 Symptoms of non-hodgkin lymphoma Lymphoma is a cancer of cells called lymphocytes. These cells are part of our immune system, which helps us to fight off infections.

More information

VAD Chemotherapy Regimen for Multiple Myeloma Information for Patients

VAD Chemotherapy Regimen for Multiple Myeloma Information for Patients VAD Chemotherapy Regimen for Multiple Myeloma Information for Patients The Regimen contains: V = vincristine (Oncovin ) A = Adriamycin (doxorubicin) D = Decadron (dexamethasone) How Is This Regimen Given?

More information

Canine Lymphoma Frequently Asked Questions by Pet Owners

Canine Lymphoma Frequently Asked Questions by Pet Owners Canine Lymphoma Frequently Asked Questions by Pet Owners What is lymphoma? The term lymphoma describes a diverse group of cancers in dogs that are derived from white blood cells called lymphocytes. Lymphocytes

More information

Treating Hodgkin s Lymphoma A Quick Guide

Treating Hodgkin s Lymphoma A Quick Guide Treating Hodgkin s Lymphoma A Quick Guide Contents This is a brief summary of the information on Treating Hodgkin s lymphoma from CancerHelp UK. You will find more detailed information on the website.

More information

Living with Chronic Kidney Disease. Divya Jain Arwindekar, DO Transplant Nephrologist University of Illinois at Chicago

Living with Chronic Kidney Disease. Divya Jain Arwindekar, DO Transplant Nephrologist University of Illinois at Chicago Living with Chronic Kidney Disease Divya Jain Arwindekar, DO Transplant Nephrologist University of Illinois at Chicago What is Chronic Kidney Disease? Chronic Kidney Disease (CKD) Gradual loss of Kidney

More information

Aggressive lymphomas. Michael Crump Princess Margaret Hospital

Aggressive lymphomas. Michael Crump Princess Margaret Hospital Aggressive lymphomas Michael Crump Princess Margaret Hospital What are the aggressive lymphomas? Diffuse large B cell Mediastinal large B cell Anaplastic large cell Burkitt lymphoma (transformed lymphoma:

More information

For the Patient: Cetuximab Injection Other names: ERBITUX

For the Patient: Cetuximab Injection Other names: ERBITUX Traditional Chinese For the Patient: Cetuximab Injection Other names: ERBITUX Cetuximab (se tux i mab) is a drug that is used to treat some types of cancer. It is a monoclonal antibody, a type of protein

More information

MEDICATION GUIDE POMALYST (POM-uh-list) (pomalidomide) capsules. What is the most important information I should know about POMALYST?

MEDICATION GUIDE POMALYST (POM-uh-list) (pomalidomide) capsules. What is the most important information I should know about POMALYST? MEDICATION GUIDE POMALYST (POM-uh-list) (pomalidomide) capsules What is the most important information I should know about POMALYST? Before you begin taking POMALYST, you must read and agree to all of

More information

PERIPHERAL STEM CELL TRANSPLANT INTRODUCTION

PERIPHERAL STEM CELL TRANSPLANT INTRODUCTION PERIPHERAL STEM CELL TRANSPLANT INTRODUCTION This booklet was designed to help you and the important people in your life understand the treatment of high dose chemotherapy with stem cell support: a procedure

More information

Understanding relapsed mantle cell lymphoma A guide for patients and caregivers

Understanding relapsed mantle cell lymphoma A guide for patients and caregivers Understanding relapsed mantle cell lymphoma A guide for patients and caregivers VELCADE (bortezomib) is approved for the treatment of patients with multiple myeloma (a cancer of the plasma cells). VELCADE

More information

Chemotherapy for Breast Cancer - Adriamycin and Cytoxan

Chemotherapy for Breast Cancer - Adriamycin and Cytoxan Chemotherapy for Breast Cancer - Adriamycin and Cytoxan Introduction Breast cancer is a common condition that affects one out of every 11 women. Your doctor has recommended chemotherapy for your breast

More information

Bone Marrow Transplantation

Bone Marrow Transplantation Bone Marrow Transplantation Introduction Bone marrow is the spongy tissue inside all of your bones, including your hip and thigh bones. The bone marrow is like a factory that makes different types of blood

More information

Diagnostics: Page 2 of 5

Diagnostics: Page 2 of 5 Proteinuria Proteinuria is a condition in which there are increased amounts of protein in the urine. There are a number of different diseases which can result in proteinuria. In the early stages of the

More information

SAMPLE CONSENT A. Informed Consent Template for Cancer Treatment Trials

SAMPLE CONSENT A. Informed Consent Template for Cancer Treatment Trials SAMPLE CONSENT A Informed Consent Template for Cancer Treatment Trials PHASE III RANDOMIZED STUDY OF CONCURRENT CHEMOTHERAPY AND PELVIC RADIATION THERAPY WITH OR WITHOUT ADJUVANT CHEMOTHERAPY IN HIGH-RISK

More information

COMMON VARIABLE IMMUNODEFICIENCY

COMMON VARIABLE IMMUNODEFICIENCY COMMON VARIABLE IMMUNODEFICIENCY This booklet is intended for use by patients and their families and should not replace advice from a clinical immunologist. 1 Also available : CHRONIC GRANULOMATOUS DISEASES

More information

Chronic Renal Disease (CRD)

Chronic Renal Disease (CRD) What do kidneys normally do? The kidneys function on many levels to maintain homeostasis (internal balance) in the body. The kidneys make urine as well as determining how concentrate or dilute the urine

More information

Intestinal Cancer. Intestinal cancer is rare. But eating a high-fat diet or having certain digestive diseases can raise a person s risk.

Intestinal Cancer. Intestinal cancer is rare. But eating a high-fat diet or having certain digestive diseases can raise a person s risk. Intestinal Cancer Introduction This reference summary discusses cancer of the small intestines, not cancer of the colon. Intestinal cancer starts in the cells of the small intestine. The small intestine

More information

[ Testicular Cancer Treatment In India at

[ Testicular Cancer Treatment In India at 2011 We care health Services Pankaj nagpal [ Testicular Cancer Treatment In India at Mumbai At Low cost] [Type the abstract of the document here. The abstract is typically a short summary of the contents

More information

ACUTE MYELOID LEUKEMIA (AML),

ACUTE MYELOID LEUKEMIA (AML), 1 ACUTE MYELOID LEUKEMIA (AML), ALSO KNOWN AS ACUTE MYELOGENOUS LEUKEMIA WHAT IS CANCER? The body is made up of hundreds of millions of living cells. Normal body cells grow, divide, and die in an orderly

More information

Autoimmune Hepatitis

Autoimmune Hepatitis Autoimmune Hepatitis National Digestive Diseases Information Clearinghouse U.S. Department of Health and Human Services NATIONAL INSTITUTES OF HEALTH What is autoimmune hepatitis? Autoimmune hepatitis

More information

Brain Cancer. This reference summary will help you understand how brain tumors are diagnosed and what options are available to treat them.

Brain Cancer. This reference summary will help you understand how brain tumors are diagnosed and what options are available to treat them. Brain Cancer Introduction Brain tumors are not rare. Thousands of people are diagnosed every year with tumors of the brain and the rest of the nervous system. The diagnosis and treatment of brain tumors

More information

Asymptomatic or smoldering myeloma with no symptoms and slow growing cancer cells

Asymptomatic or smoldering myeloma with no symptoms and slow growing cancer cells ESSENTIALS Multiple Myeloma Diagnosed with Multiple Myeloma? It s important to understand everything you can about your diagnosis, possible treatments, and places to go for support and care. Cancer is

More information

Liver Cancer And Tumours

Liver Cancer And Tumours Liver Cancer And Tumours What causes liver cancer? Many factors may play a role in the development of cancer. Because the liver filters blood from all parts of the body, cancer cells from elsewhere can

More information

What you need to know about. Multiple Myeloma. Based on a brochure from National Institutes of Health National Cancer Institute STDAVIDS.

What you need to know about. Multiple Myeloma. Based on a brochure from National Institutes of Health National Cancer Institute STDAVIDS. What you need to know about Multiple Myeloma Based on a brochure from National Institutes of Health National Cancer Institute STDAVIDS.COM What you need to know about Multiple Myeloma Introduction...1

More information

TALKING ABOUT BLOOD TRANSFUSIONS

TALKING ABOUT BLOOD TRANSFUSIONS TALKING ABOUT BLOOD TRANSFUSIONS TALKING ABOUT BLOOD TRANSFUSIONS Contents What Is a Blood Transfusion?...2 What Is the Role of Blood Transfusion in Treatment for Chronic Disease?...2 Blood and Transfusion

More information

Paclitaxel and Carboplatin

Paclitaxel and Carboplatin PATIENT EDUCATION patienteducation.osumc.edu What is Paclitaxel (pak-li-tax-el) and how does it work? Paclitaxel is a chemotherapy drug known as an anti-microtubule inhibitor. Another name for this drug

More information

R-IVAC chemotherapy for lymphoma

R-IVAC chemotherapy for lymphoma Patient information R-IVAC chemotherapy for lymphoma Introduction Your doctors have suggested that you are likely to benefit from a course of R-IVAC chemotherapy treatment. They have weighed the expected

More information

Inflammatory Myopathies- Polymyositis, Dermatomyositis

Inflammatory Myopathies- Polymyositis, Dermatomyositis Inflammatory Myopathies- Polymyositis, Dermatomyositis The prospect of a muscle disease worries some people because they are afraid of not being able to walk. Yet in many cases, treatment exists for myopathy

More information

Symptoms of Hodgkin lymphoma

Symptoms of Hodgkin lymphoma Produced 28.02.2011 Revision due 28.02.2013 Symptoms of Hodgkin lymphoma Lymphoma is a cancer of cells called lymphocytes. These cells are part of our immune system, which helps us to fight off infections.

More information

INFLAMMATORY BOWEL DISEASE. Jean-Paul Achkar, M.D. Cleveland Clinic Foundation Cleveland, OH

INFLAMMATORY BOWEL DISEASE. Jean-Paul Achkar, M.D. Cleveland Clinic Foundation Cleveland, OH INFLAMMATORY BOWEL DISEASE Jean-Paul Achkar, M.D. Cleveland Clinic Foundation Cleveland, OH 1. What is inflammatory bowel disease? Inflammatory bowel disease (IBD) refers to two related but different diseases:

More information

Understanding Myeloproliferative Neoplasms

Understanding Myeloproliferative Neoplasms Understanding Myeloproliferative Neoplasms Learn about the myeloproliferative neoplasms and their symptoms Start Here Raise Your Voice in Support of MPN Awareness! Take action and get the tools and resources

More information

Dallas Neurosurgical and Spine Associates, P.A Patient Health History

Dallas Neurosurgical and Spine Associates, P.A Patient Health History Dallas Neurosurgical and Spine Associates, P.A Patient Health History DOB: Date: Reason for your visit (Chief complaint): Past Medical History Please check corresponding box if you have ever had any of

More information

Chronic Kidney Disease

Chronic Kidney Disease Chronic Kidney Disease Introduction Chronic kidney disease, also known as CKD, is the gradual loss of kidney function. When CKD reaches an advanced stage, dangerous levels of fluid, electrolytes and wastes

More information

RADIATION THERAPY FOR LYMPHOMA. Facts to Help Patients Make an Informed Decision TARGETING CANCER CARE AMERICAN SOCIETY FOR RADIATION ONCOLOGY

RADIATION THERAPY FOR LYMPHOMA. Facts to Help Patients Make an Informed Decision TARGETING CANCER CARE AMERICAN SOCIETY FOR RADIATION ONCOLOGY RADIATION THERAPY FOR Facts to Help Patients Make an Informed Decision TARGETING CANCER CARE AMERICAN SOCIETY FOR RADIATION ONCOLOGY FACTS ABOUT The lymphatic system is a network of tiny vessels extending

More information

NORD Guides for Physicians #1. Physician s Guide to. Tyrosinemia. Type 1

NORD Guides for Physicians #1. Physician s Guide to. Tyrosinemia. Type 1 NORD Guides for Physicians #1 The National Organization for Rare Disorders Physician s Guide to Tyrosinemia Type 1 The original version of this booklet was made possible by donations in honor of Danielle

More information

What is pericarditis?

What is pericarditis? Pericarditis Guide pericarditis guide The Pericardium The pericardium is a thin, two-layered, fluid-filled sac that covers the outer surface of the heart. It shields the heart from infection or malignancy

More information

What You Need to Know About Lung Cancer Immunotherapy

What You Need to Know About Lung Cancer Immunotherapy What You Need to Know About Lung Cancer Immunotherapy Lung.org/immunotherapy What is immunotherapy? Immunotherapy for cancer, sometimes called immune-oncology, is a type of medicine that treats cancer

More information

Hodgkin Lymphoma Understanding your diagnosis

Hodgkin Lymphoma Understanding your diagnosis Hodgkin Lymphoma Understanding your diagnosis Let s Make Cancer History 1 888 939-3333 cancer.ca Hodgkin Lymphoma Understanding your diagnosis When you first hear that you have cancer you may feel alone

More information

95% of childhood kidney cancer cases are Wilms tumours. Childhood kidney cancer is extremely rare, with only 90 cases a year in

95% of childhood kidney cancer cases are Wilms tumours. Childhood kidney cancer is extremely rare, with only 90 cases a year in James Whale Fund for Kidney Cancer Childhood kidney cancer factsheet Kidney cancer rarely afflicts children and about 90 paediatric cases are diagnosed in the UK each year. About 75% of childhood kidney

More information

Mesothelioma. 1995-2013, The Patient Education Institute, Inc. www.x-plain.com ocft0101 Last reviewed: 03/21/2013 1

Mesothelioma. 1995-2013, The Patient Education Institute, Inc. www.x-plain.com ocft0101 Last reviewed: 03/21/2013 1 Mesothelioma Introduction Mesothelioma is a type of cancer. It starts in the tissue that lines your lungs, stomach, heart, and other organs. This tissue is called mesothelium. Most people who get this

More information

Gemcitabine and Cisplatin

Gemcitabine and Cisplatin PATIENT EDUCATION patienteducation.osumc.edu What is Gemcitabine (jem-site-a been)? Gemcitabine is a chemotherapy medicine known as an anti-metabolite. Another name for this drug is Gemzar. This drug is

More information

Liver Disease & Hepatitis Program Providers: Brian McMahon, MD, Steve Livingston, MD, Lisa Townshend, ANP. Primary Care Provider:

Liver Disease & Hepatitis Program Providers: Brian McMahon, MD, Steve Livingston, MD, Lisa Townshend, ANP. Primary Care Provider: Liver Disease & Hepatitis Program Providers: Brian McMahon, MD, Steve Livingston, MD, Lisa Townshend, ANP Primary Care Provider: If you are considering hepatitis C treatment, please read this treatment

More information

Infl ectra for rheumatoid arthritis

Infl ectra for rheumatoid arthritis Infl ectra for rheumatoid arthritis Some important information to get you started with your treatment This booklet is intended only for use by patients who have been prescribed Inflectra. Introduction

More information

What You Need to Know About LEMTRADA (alemtuzumab) Treatment: A Patient Guide

What You Need to Know About LEMTRADA (alemtuzumab) Treatment: A Patient Guide For Patients What You Need to Know About LEMTRADA (alemtuzumab) Treatment: A Patient Guide Patients: Your doctor or nurse will go over this patient guide with you. It is important to ask any questions

More information

AV Fistula for Dialysis

AV Fistula for Dialysis AV Fistula for Dialysis Introduction Before starting regular hemodialysis sessions, you must first prepare a vascular access. A vascular access is the site on your body where blood is removed and returned

More information

New Patient Packet Address Social Security Number D.O.B. Patient's Last Name Patient's First Name Middle Initial Age:

New Patient Packet  Address Social Security Number D.O.B. Patient's Last Name Patient's First Name Middle Initial Age: Date New Patient Packet E-mail Address Social Security Number D.O.B Patient's Last Name Patient's First Name Middle Initial Age: Home Phone: Cell Phone: Work Phone: Address Male/Female: Single/Married/Divorced/Widowed

More information

Coping with. Chronic Lymphocytic Leukaemia (CLL) Patient information

Coping with. Chronic Lymphocytic Leukaemia (CLL) Patient information Coping with Chronic Lymphocytic Leukaemia (CLL) Patient information What is CLL? Your doctor will have told you that you have a condition that affects your blood called CLL. CLL is short for Chronic Lymphocytic

More information

SARCOIDOSIS. Signs and symptoms associated with specific organ involvement can include the following:

SARCOIDOSIS. Signs and symptoms associated with specific organ involvement can include the following: SARCOIDOSIS Sarcoidosis is a disease that occurs when areas of inflammation develop in different organs of the body. Very small clusters of inflammation, called granulomas, are seen with sarcoidosis. They

More information

GFR (Glomerular Filtration Rate) A Key to Understanding How Well Your Kidneys Are Working

GFR (Glomerular Filtration Rate) A Key to Understanding How Well Your Kidneys Are Working GFR (Glomerular Filtration Rate) A Key to Understanding How Well Your Kidneys Are Working www.kidney.org National Kidney Foundation's Kidney Disease Outcomes Quality Initiative Did you know that the National

More information

ABOUT CHEMOTHERAPY. For more information, call PENN (7366) or visit our web sites: pennmedicine.org/abramson and oncolink.

ABOUT CHEMOTHERAPY. For more information, call PENN (7366) or visit our web sites: pennmedicine.org/abramson and oncolink. ABOUT CHEMOTHERAPY This Helpful Facts sheet is designed to give you basic information on chemotherapy. More detailed information can be provided by your doctor or nurse. If you have other questions, or

More information

Thinking about donating stem cells or bone marrow? Information for potential donors

Thinking about donating stem cells or bone marrow? Information for potential donors Thinking about donating stem cells or bone marrow? Information for potential donors From the Bone Marrow Transplant Team at Hamilton Health Sciences, 2015. Thinking about donating stem cells? Reading this

More information

MEDICATION GUIDE mitoxantrone (mito-xan-trone) for injection concentrate

MEDICATION GUIDE mitoxantrone (mito-xan-trone) for injection concentrate MEDICATION GUIDE mitoxantrone (mito-xan-trone) for injection concentrate Read this Medication Guide before you start receiving mitoxantrone and each time you receive mitoxantrone. There may be new information.

More information

Stimulation of blood stem cell production in bone marrow before chemotherapy

Stimulation of blood stem cell production in bone marrow before chemotherapy VI.2 Elements for a Public Summary VI.2.1 Overview of Disease Epidemiology Filgrastim can be used - to increase the number of white blood cells (WBCs) after treatment with chemotherapy to help prevent

More information

LIVING LIVER DONOR INITIAL CONSENT FOR EVALUATION

LIVING LIVER DONOR INITIAL CONSENT FOR EVALUATION LIVING LIVER DONOR INITIAL CONSENT FOR EVALUATION I am thinking about donating a part of my liver to a patient who has end stage liver disease. This patient s doctors have decided that the best treatment

More information

TC: Docetaxel and Cyclophosphamide

TC: Docetaxel and Cyclophosphamide PATIENT EDUCATION patienteducation.osumc.edu What is TC? It is the short name for the drugs used for this chemotherapy treatment. The two drugs you will receive during this treatment are Docetaxel (Taxotere

More information

Pancreatic Cancer. What does the pancreas do? What is cancer?

Pancreatic Cancer. What does the pancreas do? What is cancer? Pancreatic Cancer Pancreatic cancer mainly occurs in people over 60. If it is diagnosed at an early stage, then an operation to remove the cancer followed by chemotherapy with or without radiation therapy

More information

Corticosteroid Therapy in Inflammatory Bowel Disease

Corticosteroid Therapy in Inflammatory Bowel Disease 2014 Corticosteroid Therapy in Inflammatory Bowel Disease Corticosteroid Therapy in Inflammatory Bowel Disease What are corticosteroids? Corticosteroids (kor-ti-koh-ster-oids) are strong inhibitors of

More information

Lung Cancer. This reference summary will help you better understand lung cancer and the treatment options that are available.

Lung Cancer. This reference summary will help you better understand lung cancer and the treatment options that are available. Lung Cancer Introduction Lung cancer is the number one cancer killer of men and women. Over 165,000 people die of lung cancer every year in the United States. Most cases of lung cancer are related to cigarette

More information

Smoking and misuse of certain pain medicines can affect the risk of developing renal cell cancer.

Smoking and misuse of certain pain medicines can affect the risk of developing renal cell cancer. Renal cell cancer Renal cell cancer is a disease in which malignant (cancer) cells form in tubules of the kidney. Renal cell cancer (also called kidney cancer or renal adenocarcinoma) is a disease in which

More information

Background Information Myeloma

Background Information Myeloma Myeloma FAST FACTS Myeloma, also known as multiple myeloma, is a type of cancer that develops from plasma cells which originate in the bone marrow 1 Myeloma is the second most common type of blood cancer

More information

Laparoscopic Splenectomy and Adrenalectomy. A simple guide to help answer your questions about surgery

Laparoscopic Splenectomy and Adrenalectomy. A simple guide to help answer your questions about surgery Laparoscopic Splenectomy and Adrenalectomy A simple guide to help answer your questions about surgery What is a spleen? The spleen is a solid organ that lies in the upper left side of the abdomen, just

More information

PATIENT HEALTH QUESTIONNAIRE Radiation Oncology (Patient Label)

PATIENT HEALTH QUESTIONNAIRE Radiation Oncology (Patient Label) REVIEWED DATE / INITIALS SAFETY: Are you at risk for falls? Do you have a Pacemaker? Females; Is there a possibility you may be pregnant? ALLERGIES: Do you have any allergies to medications? If, please

More information

Your Guide to XLP. X-linked Lymphoproliferative Disease

Your Guide to XLP. X-linked Lymphoproliferative Disease Your Guide to XLP X-linked Lymphoproliferative Disease What is XLP? XLP stands for X-linked lymphoproliferative disease. XLP is a genetic condition where the immune system doesn t work as it should. XLP

More information

Medication Guide TASIGNA (ta-sig-na) (nilotinib) Capsules

Medication Guide TASIGNA (ta-sig-na) (nilotinib) Capsules Medication Guide TASIGNA (ta-sig-na) (nilotinib) Capsules Read this Medication Guide before you start taking Tasigna and each time you get a refill. There may be new information. This information does

More information

Skin cancer Patient information

Skin cancer Patient information Skin cancer Patient information What is cancer? The human body is made up of billions of cells. In healthy people, cells grow, divide and die. New cells constantly replace old ones in an orderly way. This

More information

Understanding. Chronic Kidney Disease

Understanding. Chronic Kidney Disease R E N A L R E S O U R C E C E N T R E Understanding Chronic Kidney Disease Causes of Chronic Kidney Disease Most causes of chronic kidney failure are diseases that are not usually accompanied by symptoms

More information

Living with multiple myeloma A guide for patients and caregivers

Living with multiple myeloma A guide for patients and caregivers Living with multiple myeloma A guide for patients and caregivers VELCADE (bortezomib) is approved for the treatment of patients with multiple myeloma (a cancer of the plasma cells). Before you receive

More information

chronic leukemia lymphoma myeloma differentiated 14 September 1999 Pre- Transformed Ig Surface Surface Secreted Myeloma Major malignant counterpart

chronic leukemia lymphoma myeloma differentiated 14 September 1999 Pre- Transformed Ig Surface Surface Secreted Myeloma Major malignant counterpart Disease Usual phenotype acute leukemia precursor chronic leukemia lymphoma myeloma differentiated Pre- B-cell B-cell Transformed B-cell Plasma cell Ig Surface Surface Secreted Major malignant counterpart

More information

Sincerely, Cindi. Cindi Crews Patient Services Coordinator for Dr. John Aucott Lyme Disease Clinical Research Center

Sincerely, Cindi. Cindi Crews Patient Services Coordinator for Dr. John Aucott Lyme Disease Clinical Research Center Lyme Disease Clinical Research Center 2360 W. Joppa Road Joppa Concourse Suite 320 Lutherville, MD 21093 410-616-7596 Telephone 410-616-7595 Fax Please fill out the attached questionnaire and if possible

More information

TCH: Docetaxel, Carboplatin and Trastuzumab

TCH: Docetaxel, Carboplatin and Trastuzumab PATIENT EDUCATION patienteducation.osumc.edu TCH: Docetaxel, Carboplatin and Trastuzumab What is TCH? It is the short name for the drugs used for this chemotherapy treatment. The three drugs you will receive

More information

Prostate Cancer. There is no known association with an enlarged prostate or benign prostatic hyperplasia (BPH).

Prostate Cancer. There is no known association with an enlarged prostate or benign prostatic hyperplasia (BPH). Prostate Cancer Definition Prostate cancer is cancer that starts in the prostate gland. The prostate is a small, walnut-sized structure that makes up part of a man's reproductive system. It wraps around

More information

Tests / Procedures Date Where was procedure done?

Tests / Procedures Date Where was procedure done? New Patient Worksheet For Appointment Scheduled with: Date: Time: Personal Information (Please PRINT and complete all sections) Patient Name Date of Birth Address Gender M F City St E-mail Zip Phone Cell

More information

UNDERSTANDING MULTIPLE MYELOMA AND YOUR TREATMENT. It is not known if REVLIMID is safe and effective in children under 18 years of age My Moment

UNDERSTANDING MULTIPLE MYELOMA AND YOUR TREATMENT. It is not known if REVLIMID is safe and effective in children under 18 years of age My Moment TREATMENT OVERVIEW REVLIMID (lenalidomide) is used with dexamethasone to treat patients with multiple myeloma (MM) REVLIMID should not be used to treat people who have chronic lymphocytic leukemia (CLL)

More information

Patient Medication Guide Brochure

Patient Medication Guide Brochure Patient Medication Guide Brochure 1 MEDICATION GUIDE TASIGNA (ta-sig-na) (nilotinib) Capsules Read this Medication Guide before you start taking TASIGNA and each time you get a refill. There may be new

More information

Biologic Treatments for Rheumatoid Arthritis

Biologic Treatments for Rheumatoid Arthritis Biologic Treatments Rheumatoid Arthritis (also known as cytokine inhibitors, TNF inhibitors, IL 1 inhibitor, or Biologic Response Modifiers) Description Biologics are new class of drugs that have been

More information

RESTRICTIVE CARDIOMYOPATHY

RESTRICTIVE CARDIOMYOPATHY RESTRICTIVE CARDIOMYOPATHY Restrictive cardiomyopathy (RCM) is a rare form of heart muscle disease that is characterized by restrictive filling of the ventricles. In this disease the contractile function

More information

Laparoscopic Spleen Removal (Splenectomy) Patient Information from SAGES

Laparoscopic Spleen Removal (Splenectomy) Patient Information from SAGES Laparoscopic Spleen Removal (Splenectomy) Patient Information from SAGES What is the Spleen? The spleen is a blood filled organ located in the upper left abdominal cavity. It is a storage organ for red

More information

Emergency Care CHAPTER. Hematologic and Renal Emergencies THIRTEENTH EDITION. Emergency Care, 13e Daniel Limmer Michael F. O'Keefe

Emergency Care CHAPTER. Hematologic and Renal Emergencies THIRTEENTH EDITION. Emergency Care, 13e Daniel Limmer Michael F. O'Keefe Emergency Care THIRTEENTH EDITION CHAPTER 24 Hematologic and Renal Emergencies Multimedia Directory Slide 15 Slide 40 Sickle Cell Anemia Video Information About Renal Failure Video Topics The Hematologic

More information