A Study To Evaluate PF With Chemotherapy In Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

Size: px
Start display at page:

Download "A Study To Evaluate PF With Chemotherapy In Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome"

Transcription

1 A service of the U.S. National Institutes of Health Trial record 1 of 5 for: efficacy of PF Previous Study Return to List Next Study A Study To Evaluate PF With Chemotherapy In Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome This study is currently recruiting participants. (see Contacts and Locations) Verified October 2014 by Sponsor: Information prov ided by (Responsible Party): ClinicalTrials.gov Identifier: NCT First received: March 1, 2012 Last updated: October 30, 2014 Last verified: October 2014 History of Changes Full Text View Tabular View No Study Results Posted Disclaimer How to Read a Study Record Purpose This is a study to evaluate PF (an inhibitor of the Hedgehog pathw ay) in Acute Myeloid Leukemia and high-risk Myelodysplastic Syndrome in combination w ith standard agents used to treat these diseases. Condition Interv ention Phase Acute Myeloid Leukemia Drug: Decitabine Phase 1 Phase 2 Study Type: Study Design: Official Title: Interventional Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment A Phase 1B/2 Study To Evaluate The Safety And Efficacy Of PF , An Oral Hedgehog Inhibitor, In Combination With Intensive Chemotherapy, Low Dose Ara-C Or Decitabine In Patients With Acute Myeloid Leukemia Or High Risk Myelodysplastic Syndrome Resource links prov ided by NLM: Genetics Home Reference related topics: core binding factor acute myeloid leukemia cytogenetically normal acute myeloid leukemia familial acute myeloid leukemia w ith mutated CEBPA MedlinePlus related topics: Acute Myeloid Leukemia Leukemia Myelodysplastic Syndromes Drug Information available for: Cytarabine Decitabine Daunorubicin Daunorubicin hydrochloride Daunorubicin citrate Genetic and Rare Diseases Information Center resources: Acute Myelocytic Leukemia Acute Non Lymphoblastic Leukemia Leukemia, Myeloid Myelodysplastic Syndromes U.S. FDA Resources Further study details as prov ided by :

2 Primary Outcome Measures: Number of participants w ith Dose-limiting toxicities (DLT) [ Time Frame: 1 -year ] [ Designated as safety issue: Yes ] (Phase 1B) Percentage of patients w ith Complete Response rate [ Time Frame: 2-years ] [ Designated as safety issue: No ] Complete response are those w ith repeat bone marrow show ing less than 5 percent (%) myeloblasts w ith normal peripheral blood values. (Phase 2 Fit) Overall Survival (OS) [ Time Frame: 48 months ] [ Designated as safety issue: No ] Time from the start of study treatment to date of death due to any cause. (Phase 2 Unfit) Secondary Outcome Measures: Area Under the Curve from Time Zero to end of dosing interval (AUCtau) [ Time Frame: 2 years ] [ Designated as safety issue: No ] Not Specified Overall Survival (OS) [ Time Frame: 48 months ] [ Designated as safety issue: No ] Time from the start of study treatment to date of death due to any cause. (Phase 1B; Phase 2 Fit) Percentage of patients w ith disease-specific efficacy for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) [ Time Frame: 2 years ] [ Designated as safety issue: No ] (Phase 2 Fit and Unfit) Percentage of patients w ith Complete Response rate / Complete Response rate w ith incomplete blood count recovery [ Time Frame: 2 years ] [ Designated as safety issue: No ] Complete response are those w ith repeat bone marrow show ing less than 5 percent (%) myeloblasts w ith normal peripheral blood values. (Phase 1B; Phase 2 Unfit); Complete response w ith incomplete blood count recovery are those w ith repeat bone marrow show ing less than 5 percent (%) myeloblasts w ith either platelets or neutrophils not recovered. Cumulative incidence of relapse (CIR), relapse free survival (RFS), event free survival (EFS), and cumulative incidence of death (CID) [ Time Frame: 48 months ] [ Designated as safety issue: No ] RFS, CIR and CID are defined only for patients achieving CR or CRi (Phase 2 Fit and Unfit); EFS (P2 Fit only) is defined as the time from C1D-3 to date of induction treatment failure, or relapse from CR or CRi, or death from any cause. QTc Interval [ Time Frame: 2 years ] [ Designated as safety issue: Yes ] Disease-related gene mutation (PD biomarkers) [ Time Frame: 2 years ] [ Designated as safety issue: No ] Changes in analyte levels from baseline to post-treatment (PD biomarkers) [ Time Frame: 2 years ] [ Designated as safety issue: No ] Changes in gene levels from baseline to post-treatment (PD biomarkers) [ Time Frame: 2 years ] [ Designated as safety issue: No ] Detectable tumor Gli1 expression (PD Biomarkers) [ Time Frame: 2 years ] [ Designated as safety issue: No ] Estimated Enrollment: 265 Study Start Date: July 2012 Estimated Study Completion Date: September 2016 Estimated Primary Completion Date: September 2016 (Final data collection date for primary outcome measure)

3 Arms Experimental: Arm A (Phase 1B) PF in combination w ith low dose ARA-C (LDAC) Experimental: Arm B (Phase 1B) PF in combination w ith Decitabine Experimental: Arm C (Phase 1B) PF in combination w ith intensive chemotherapy: PF administered continuously for 28 days. Daunorubicin given using 60 mg/m2 for 3-days together w ith cytarabine 100 mg/m2 on days 1 through 7 follow ed by cytarabine 1g/m2 on days 1, 3, and 5 during 2-4 cycles of consolidation therapy. Experimental: P2 Fit (Phase 2 Single Arm) PF in combination w ith intensive chemotherapy: PF administered continuously for 28 days. Daunorubicin given using 60 mg/m2 for 3-days together w ith cytarabine 100 mg/m2 on days 1 through 7 follow ed by cytarabine 1g/m2 on days 1, 3, and 5 during 2-4 cycles of consolidation therapy. P2 Unfit (Phase 2 Randomized) Patients w ill be randomized 2:1 (low dose ARA-C in combination w ith PF : low dose ARA-C alone). Assigned Interv entions continuously for 28-days. Low dose ARA-C (LDAC) administered at 20 mg SQ, BID on Days 1 through 10. continuously for 28 days. Drug: Decitabine Decitabine given at 20 mg/m2 over 1 hour infusion for 5-days continuously for 28 days Daunorubicin given using 60 mg/m2 for 3-days Cytarabine 100 mg/m2 on days 1 through 7 continuously for 28 days Daunorubicin given using 60 mg/m2 for 3-days Cytarabine 100 mg/m2 on days 1 through 7 continuously for 28 days (if randomized to receive PF ) Low dose ARA-C (LDAC) administered at 20 mg SQ, BID on Days 1 through 10. Eligibility Ages Eligible for Study: Genders Eligible for Study: Accepts Healthy Volunteers: 18 Years and older Both No Criteria Inclusion Criteria: Patients w ith AML or RAEB 2 High Risk MDS w ho are new ly diagnosed according to the WHO 2008 Classification and previously untreated. Patients w ith AML (arising from an antecedent hematologic disease [AHD]) or MDS w ho may have had one prior regimen w ith commercially available agents for the treatment of their prior hematologic disease. The patients may not have had a prior therapy for their AML. AML patients include de novo AML, AML evolving from MDS or other AHD and AML after previous cytotoxic therapy or radiation (secondary AML) For a diagnosis of AML, a bone marrow blast count of 20% or more is required.

4 For a diagnosis of high-risk Myelodysplastic Syndrome RAEB 2 the patient must have 10-19% bone marrow blasts Adequate Organ Function ECOG Performance Status 0, 1, or 2 Exclusion Criteria: AML M3 Acute Promyelocytic Leukemia (APL) or patients w ith a t(9:22) cytogenetic translocation. Patients w ith know n active uncontrolled central nervous system (CNS) leukemia. Contacts and Locations Choosing to participate in a study is an important personal decision. Talk w ith your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies. Please refer to this study by its ClinicalTrials.gov identifier: NCT Contacts Contact: CT.gov Call Center Show 62 Study Locations Sponsors and Collaborators Inv estigators Study Director: CT.gov Call Center More Information Additional Information: To obtain contact information for a study center near you, click here. No publications provided Responsible Party: ClinicalTrials.gov Identifier: NCT History of Changes Other Study ID Numbers: B Study First Received: March 1, 2012 Last Updated: October 30, 2014 Health Authority: United States: Food and Drug Administration Keyw ords provided by : Hedgehog Inhibitor Acute Myeloid Leukemia Myelodysplastic syndrome Intensive chemotherapy LDAC Additional relevant MeSH terms: Leukemia Leukemia, Myeloid Leukemia, Myeloid, Acute Myelodysplastic Syndromes Preleukemia Syndrome Bone Marrow Diseases Disease Hematologic Diseases Neoplasms Neoplasms by Histologic Type Pathologic Processes Precancerous Conditions Decitabine Anti-Infective Agents Antibiotics, Antineoplastic Antimetabolites Antimetabolites, Antineoplastic Antineoplastic Agents Antiviral Agents Enzyme Inhibitors Immunologic Factors Immunosuppressive Agents Molecular Mechanisms of Pharmacological Action Pharmacologic Actions Physiological Effects of Drugs

5 Cytarabine Daunorubicin Therapeutic Uses Topoisomerase II Inhibitors ClinicalTrials.gov processed this record on November 16, 2014

Aelines Guid for intrathecal chemotherapy

Aelines Guid for intrathecal chemotherapy cute Promyelocytic Leukemia Updated April 2008 by Dr. Richard Wells* Updates: Aelines Guid for intrathecal chemotherapy Introduction Acute promyelocytic leukemia (APL) is a subtype of AML according to

More information

SWOG ONCOLOGY RESEARCH PROFESSIONAL (ORP) MANUAL VOLUME I LEUKEMIA FORMS CHAPTER 16A REVISED: SEPTEMBER 2016

SWOG ONCOLOGY RESEARCH PROFESSIONAL (ORP) MANUAL VOLUME I LEUKEMIA FORMS CHAPTER 16A REVISED: SEPTEMBER 2016 LEUKEMIA FORMS The guidelines and figures below are specific to Leukemia studies. The information in this manual does NOT represent a complete set of required forms for any leukemia study. Please refer

More information

The Correlation Between Blood omega3 and ADHD

The Correlation Between Blood omega3 and ADHD The Correlation Between Blood omega3 and ADHD This study is not yet open for participant recruitment. (see Contacts and Locations) Verified March 2015 by Ziv Hospital Sponsor: Ayelet Omer Armon Information

More information

PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES

PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES LEUKEMIA ACUTE MYELOID LEUKEMIA Leukemia Site Group Acute Myeloid Leukemia (AML) 1. INTRODUCTION 3 2. PREVENTION 3 3. SCREENING AND EARLY DETECTION

More information

Pan Birmingham Cancer Network: Haematology NSSG Chemotherapy Regimens AML intensive v1.0 August 2010

Pan Birmingham Cancer Network: Haematology NSSG Chemotherapy Regimens AML intensive v1.0 August 2010 AML - TRIALS It is best practise for all patients to be treated on the appropriate NCRI national trial for AML. It is outside of the remit for this regimen list to provide a comprehensive detail of the

More information

Introduction. About 10,500 new cases of acute myelogenous leukemia are diagnosed each

Introduction. About 10,500 new cases of acute myelogenous leukemia are diagnosed each Introduction 1.1 Introduction: About 10,500 new cases of acute myelogenous leukemia are diagnosed each year in the United States (Hope et al., 2003). Acute myelogenous leukemia has several names, including

More information

Acute Myeloid Leukemia

Acute Myeloid Leukemia Acute Myeloid Leukemia Upfront Therapy in Newly Diagnosed Elderly AML Patients: Is Decitabine (DAC) the new standard? Raoul Tibes, MD, PhD Senior Associate Consultant, Mayo Clinic Arizona Associate Director,

More information

Contact: Rebecca Wong (415) Questions and Answers Regarding Vidaza (azacitidine for injectable suspension) and Demethylating Agents

Contact: Rebecca Wong (415) Questions and Answers Regarding Vidaza (azacitidine for injectable suspension) and Demethylating Agents Contact: Rebecca Wong (415) 278-3319 Questions and Answers Regarding Vidaza (azacitidine for injectable suspension) and Demethylating Agents The recent approval of a third drug for the treatment of MDS

More information

PROGNOSIS IN ACUTE LYMPHOBLASTIC LEUKEMIA PROGNOSIS IN ACUTE MYELOID LEUKEMIA

PROGNOSIS IN ACUTE LYMPHOBLASTIC LEUKEMIA PROGNOSIS IN ACUTE MYELOID LEUKEMIA PROGNOSIS IN ACUTE LYMPHOBLASTIC LEUKEMIA UNFAVORABLE Advanced age High leukocyte count at diagnosis Presence of myeloid antigens Late achievement of CR Chromosomal abnormalities: t(9:22)(q34:q11) t(4;11)(q21;q23)

More information

AML: How to characterize and treat elderly patients non fit for standard chemotherapy

AML: How to characterize and treat elderly patients non fit for standard chemotherapy m1 AML: How to characterize and treat elderly patients non fit for standard chemotherapy Clinic for Medicine III University Hospital Munich Campus Grosshadern AMLCG study group Karsten Spiekermann, MD

More information

Phase 1 Trial of M SC A, an Inhibitor of a DNA-dependent Protein Kinase, in Combination With Radiothe rapy

Phase 1 Trial of M SC A, an Inhibitor of a DNA-dependent Protein Kinase, in Combination With Radiothe rapy A service of the U.S. National Institutes of Health Trial record 1 of 2 for: MSC2490484A Previous Study Return to List Next Study Phase 1 Trial of M SC2490484A, an Inhibitor of a DNA-dependent Protein

More information

STUDY PROTOCOL. Fabio Ciceri M.D. Istituto Scientifico H. San Raffaele Dept. of of Oncology, Haematology/Transplant Unit I-20132 Milan

STUDY PROTOCOL. Fabio Ciceri M.D. Istituto Scientifico H. San Raffaele Dept. of of Oncology, Haematology/Transplant Unit I-20132 Milan STUDY PROTOCOL Clinical phase II trial to evaluate the safety and efficacy of treosulfan combined with cytarabine and fludarabine prior to autologous haematopoietic stem cell transplantation in elderly

More information

SWOG ONCOLOGY RESEARCH PROFESSIONAL (ORP) MANUAL VOLUME I RESPONSE ASSESSMENT LEUKEMIA CHAPTER 11A REVISED: OCTOBER 2015

SWOG ONCOLOGY RESEARCH PROFESSIONAL (ORP) MANUAL VOLUME I RESPONSE ASSESSMENT LEUKEMIA CHAPTER 11A REVISED: OCTOBER 2015 LEUKEMIA Response in Acute Myeloid Leukemia (AML) Response criteria in Acute Myeloid Leukemia for SWOG protocols is based on the review article Diagnosis and management of acute myeloid leukemia in adults:

More information

Overview of Myelodysplastic Syndromes. November 09, 2012 Kim-Hien Dao, DO, PhD 11/9/2012. Speakers. Overview of MDS

Overview of Myelodysplastic Syndromes. November 09, 2012 Kim-Hien Dao, DO, PhD 11/9/2012. Speakers. Overview of MDS Overview of Myelodysplastic Syndromes November 09, 2012 Kim-Hien Dao, DO, PhD Speakers Kim-Hien Dao, DO, PhD OVERVIEW Oregon Health Sciences University, Portland, OR Gabrielle Meyers, MD LOW RISK MDS Oregon

More information

ACUTE LYMPHOBLASTIC LEUKEMIA ~ STUDY #1

ACUTE LYMPHOBLASTIC LEUKEMIA ~ STUDY #1 ACUTE LYMPHOBLASTIC LEUKEMIA ~ STUDY #1 Title: COG AALL06N1: A Study of Neurocognitive Function in Children Treated for ALL. Purpose: To determine the effects, if any, of methotrexate, on learning skills

More information

Acute Myeloid Leukaemia Guidelines

Acute Myeloid Leukaemia Guidelines Acute Myeloid Leukaemia Guidelines Approved by Pathway Board for Haematological Malignancies Coordinating author: Matthew Smith, Bart s Health NHST Date of issue: 12.03.2015 Version number: 1.0 These guidelines

More information

1 of 6 6/1/13 6:49 PM

1 of 6 6/1/13 6:49 PM A service of the U.S. National Institutes of Health Trial record 7 of 203 for: Melanoma Analysis Previous Study Return to List Next Study Expression Analysis of Specific Markers in Non-small Cell Lung

More information

Long Term Low Dose Maintenance Chemotherapy in the Treatment of Acute Myeloid Leukemia

Long Term Low Dose Maintenance Chemotherapy in the Treatment of Acute Myeloid Leukemia Long Term Low Dose Chemotherapy in the Treatment of Acute Myeloid Leukemia Murat TOMBULO LU*, Seçkin ÇA IRGAN* * Department of Hematology, Faculty of Medicine, Ege University, zmir, TURKEY ABSTRACT In

More information

DECISION AND SUMMARY OF RATIONALE

DECISION AND SUMMARY OF RATIONALE DECISION AND SUMMARY OF RATIONALE Indication under consideration Clinical evidence Clofarabine in the treatment of relapsed acute myeloid leukaemia (AML) The application was for clofarabine to remain in

More information

Clinical Trial Design. Sponsored by Center for Cancer Research National Cancer Institute

Clinical Trial Design. Sponsored by Center for Cancer Research National Cancer Institute Clinical Trial Design Sponsored by Center for Cancer Research National Cancer Institute Overview Clinical research is research conducted on human beings (or on material of human origin such as tissues,

More information

Acute myeloid leukemia (AML)

Acute myeloid leukemia (AML) Acute myeloid leukemia (AML) Adult acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells, or platelets. Adult

More information

Acute Myeloid Leukemia

Acute Myeloid Leukemia Acute Myeloid Leukemia Introduction Leukemia is cancer of the white blood cells. The increased number of these cells leads to overcrowding of healthy blood cells. As a result, the healthy cells are not

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem-cell_transplantation_for_epithelial_ovarian_cancer 2/2001 11/2015 11/2016 11/2015 Description

More information

Treatment of Low Risk MDS. Overview. Myelodysplastic Syndromes (MDS)

Treatment of Low Risk MDS. Overview. Myelodysplastic Syndromes (MDS) Overview Amy Davidoff, Ph.D., M.S. Associate Professor Pharmaceutical Health Services Research Department, Peter Lamy Center on Drug Therapy and Aging University of Maryland School of Pharmacy Clinical

More information

Stakeholder Insight: Acute Leukemias - Reaching the Limits of Cytotoxic Chemotherapy

Stakeholder Insight: Acute Leukemias - Reaching the Limits of Cytotoxic Chemotherapy Brochure More information from http://www.researchandmarkets.com/reports/1088137/ Stakeholder Insight: Acute Leukemias - Reaching the Limits of Cytotoxic Chemotherapy Description: The drug therapy of acute

More information

LEUCEMIA MIELOIDE ACUTA. A.M. Carella U.O.C. Ematologia IRCCS AOU San Martino IST, Genova

LEUCEMIA MIELOIDE ACUTA. A.M. Carella U.O.C. Ematologia IRCCS AOU San Martino IST, Genova LEUCEMIA MIELOIDE ACUTA A.M. Carella U.O.C. Ematologia IRCCS AOU San Martino IST, Genova Impact of mutational analysis in AML C. Thiede Optimal acute myeloid leukemia therapy in 2012 H. Dombret Acquired

More information

Cytogenetic Profile of Monosomal Karyotype in Adult Acute Myeloid Leukemia

Cytogenetic Profile of Monosomal Karyotype in Adult Acute Myeloid Leukemia International Journal of Scientific and Research Publications, Volume 3, Issue 11, November 2013 1 Cytogenetic Profile of Monosomal Karyotype in Adult Acute Myeloid Leukemia Yuet-Meng Chin, Puteri J Noor,

More information

CML. cure. A Patient s Guide. Molecular Biology Diagnosis Stem Cell Transplant Monitoring New Drugs Questions to Ask and More

CML. cure. A Patient s Guide. Molecular Biology Diagnosis Stem Cell Transplant Monitoring New Drugs Questions to Ask and More A Patient s Guide to CML Molecular Biology Diagnosis Stem Cell Transplant Monitoring New Drugs Questions to Ask and More cure C a n c e r U p d at e s, R e s e a r c h & E d u c at i o n Based on science,

More information

REFERENCE CODE GDHC003POA PUBLICAT ION DATE AUGUST 2013

REFERENCE CODE GDHC003POA PUBLICAT ION DATE AUGUST 2013 REFERENCE CODE GDHC003POA PUBLICAT ION DATE AUGUST 2013 ACUTE MYELOID LEUKEMIA (AML) - Executive Summary AML: Key Metrics in Six Major Pharmaceutical Markets, 2012 2017 2012 Epidemiology Incident Population

More information

Active centers: 2. Number of patients/subjects: Planned: 20 Randomized: Treated: 20 Evaluated: Efficacy: 13 Safety: 20

Active centers: 2. Number of patients/subjects: Planned: 20 Randomized: Treated: 20 Evaluated: Efficacy: 13 Safety: 20 These results are supplied for informational purposes only. Prescribing decisions should be made based on the approved package insert in the country of prescription Sponsor/company: sanofi-aventis ClinialTrials.gov

More information

Early mortality rate (EMR) in Acute Myeloid Leukemia (AML)

Early mortality rate (EMR) in Acute Myeloid Leukemia (AML) Early mortality rate (EMR) in Acute Myeloid Leukemia (AML) George Yaghmour, MD Hematology Oncology Fellow PGY5 UTHSC/West cancer Center, Memphis, TN May,1st,2015 Off-Label Use Disclosure(s) I do not intend

More information

Role of taxanes in the treatment of advanced NHL patients: A randomized study of 87 cases

Role of taxanes in the treatment of advanced NHL patients: A randomized study of 87 cases Role of taxanes in the treatment of advanced NHL patients: A randomized study of 87 cases R. Shraddha, P.N. Pandit Radium Institute, Patna Medical College and Hospital, Patna, India Abstract NHL is a highly

More information

Project Lead: Stephen Forman, M.D. PI: Elizabeth Budde, M.D., Ph.D

Project Lead: Stephen Forman, M.D. PI: Elizabeth Budde, M.D., Ph.D Phase I study using T cells expressing a CD123-specific chimeric antigen receptor and truncated EGFR for patients with relapsed or refractory acute myeloid leukemia Project Lead: Stephen Forman, M.D. PI:

More information

If several different trials are mentioned in one publication, the data of each should be extracted in a separate data extraction form.

If several different trials are mentioned in one publication, the data of each should be extracted in a separate data extraction form. General Remarks This template of a data extraction form is intended to help you to start developing your own data extraction form, it certainly has to be adapted to your specific question. Delete unnecessary

More information

I was just diagnosed, so my doctor and I are deciding on treatment. My doctor said there are several

I was just diagnosed, so my doctor and I are deciding on treatment. My doctor said there are several Track 3: Goals of therapy I was just diagnosed, so my doctor and I are deciding on treatment. My doctor said there are several factors she ll use to decide what s best for me. Let s talk about making treatment

More information

HKU Identifies Homoharringtonine as Effective Treatment for FLT3 Mutant Acute Myeloid Leukaemia for the First Time in the World

HKU Identifies Homoharringtonine as Effective Treatment for FLT3 Mutant Acute Myeloid Leukaemia for the First Time in the World HKU Identifies Homoharringtonine as Effective Treatment for FLT3 Mutant Acute Myeloid Leukaemia for the First Time in the World Press Conference October 31, 2016 Speakers Professor Anskar Leung Yu-hung

More information

Efficacy, safety and preference study of a insulin pen PDS290 vs. a Novo Nordisk marketed insulin pen in diabetics

Efficacy, safety and preference study of a insulin pen PDS290 vs. a Novo Nordisk marketed insulin pen in diabetics Efficacy, safety and preference study of a insulin pen PDS290 vs. a Novo Nordisk marketed insulin pen in diabetics This trial is conducted in the United States of America (USA). The aim of this clinical

More information

My Sister s s Keeper. Science Background Talk

My Sister s s Keeper. Science Background Talk My Sister s s Keeper Science Background Talk Outline Acute promyelocytic leukemia (APL) APL Treatment Savior Siblings In vitro fertilization (IVF) Pre-implantation Genetic Diagnosis (PGD) Risks of donating

More information

Guidance for Industry Information Program on Clinical Trials for Serious or Life-Threatening Diseases and Conditions

Guidance for Industry Information Program on Clinical Trials for Serious or Life-Threatening Diseases and Conditions Guidance for Industry Information Program on Clinical Trials for Serious or Life-Threatening Diseases and Conditions U.S. Department of Health and Human Services Food and Drug Administration Center for

More information

Hematopoietic Stem Cell Transplantation. Imad A. Tabbara, M.D. Professor of Medicine

Hematopoietic Stem Cell Transplantation. Imad A. Tabbara, M.D. Professor of Medicine Hematopoietic Stem Cell Transplantation Imad A. Tabbara, M.D. Professor of Medicine Hematopoietic Stem Cells Harvested from blood, bone marrow, umbilical cord blood Positive selection of CD34 (+) cells

More information

Evaluation of focal adhesions as new therapeutic targets in acute myeloid leukemia

Evaluation of focal adhesions as new therapeutic targets in acute myeloid leukemia Evaluation of focal adhesions as new therapeutic targets in acute myeloid leukemia Dr Jordi Sierra Gil IRHSP Institut de Recerca Hospital de la Santa Creu i Sant Pau Dr. Miguel Ángel Sanz Alonso Fundación

More information

Estimated New Cases of Leukemia, Lymphoma, Myeloma 2014

Estimated New Cases of Leukemia, Lymphoma, Myeloma 2014 ABOUT BLOOD CANCERS Leukemia, Hodgkin lymphoma (HL), non-hodgkin lymphoma (NHL), myeloma, myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs) are types of cancer that can affect the

More information

Acute Myeloid Leukemia Therapeutics Market to 2020

Acute Myeloid Leukemia Therapeutics Market to 2020 Brochure More information from http://www.researchandmarkets.com/reports/3030124/ Acute Myeloid Leukemia Therapeutics Market to 2020 Description: Summary: Treatment and prognosis in AML is strongly influenced

More information

EISAI INC. FDA ODAC BRIEFING DOCUMENT NDA 021790/S-010. DACOGEN (decitabine) INDICATION: ACUTE MYELOID LEUKEMIA MEETING DATE: FEBRUARY 09, 2012

EISAI INC. FDA ODAC BRIEFING DOCUMENT NDA 021790/S-010. DACOGEN (decitabine) INDICATION: ACUTE MYELOID LEUKEMIA MEETING DATE: FEBRUARY 09, 2012 EISAI INC. FDA ODAC BRIEFING DOCUMENT NDA 021790/S-010 DACOGEN (decitabine) INDICATION: ACUTE MYELOID LEUKEMIA MEETING DATE: FEBRUARY 09, 2012 ADVISORY COMMITTEE BRIEFING MATERIALS: AVAILABLE FOR PUBLIC

More information

A Career in Pediatric Hematology-Oncology? Think About It...

A Career in Pediatric Hematology-Oncology? Think About It... A Career in Pediatric Hematology-Oncology? Think About It... What does a pediatric hematologist-oncologist do? What kind of training is necessary? Is there a future need for specialists in this area? T

More information

Relapsed or Refractory Adult Acute Lymphoblastic Leukemia (ALL): Distinct Patient Populations With Significant Unmet Medical Need

Relapsed or Refractory Adult Acute Lymphoblastic Leukemia (ALL): Distinct Patient Populations With Significant Unmet Medical Need Relapsed or Refractory Adult Acute Lymphoblastic Leukemia (ALL): Distinct Patient Populations With Significant Unmet Medical Need Hagop M. Kantarjian, MD Chairman, Leukemia Department Department of Hematology

More information

CI-1. DACOGEN (decitabine) United States Food and Drug Administration Oncologic Drugs Advisory Committee February 9, 2012 NDA #21790/S-010

CI-1. DACOGEN (decitabine) United States Food and Drug Administration Oncologic Drugs Advisory Committee February 9, 2012 NDA #21790/S-010 CI-1 DACOGEN (decitabine) United States Food and Drug Administration Oncologic Drugs Advisory Committee February 9, 2012 NDA #21790/S-010 CI-2 Introduction Alton Kremer, MD, PhD Senior Vice President,

More information

LEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials

LEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials LEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials OUR FOCUS ABOUT emerging treatments Presentation for: Judith E. Karp, MD Advancements for Acute Myelogenous Leukemia Supported by an unrestricted educational

More information

National MS Society Information Sourcebook www.nationalmssociety.org/sourcebook

National MS Society Information Sourcebook www.nationalmssociety.org/sourcebook National MS Society Information Sourcebook www.nationalmssociety.org/sourcebook Chemotherapy The literal meaning of the term chemotherapy is to treat with a chemical agent, but the term generally refers

More information

Clinical trials. Patient information. For anyone affected by blood cancer. bloodwise.org.uk

Clinical trials. Patient information. For anyone affected by blood cancer. bloodwise.org.uk Clinical trials For anyone affected by blood cancer bloodwise.org.uk Patient information A note about this booklet This booklet has been produced by Bloodwise, the new name for Leukaemia & Lymphoma Research.

More information

MEDICAL COVERAGE POLICY

MEDICAL COVERAGE POLICY Important note Even though this policy may indicate that a particular service or supply is considered covered, this conclusion is not necessarily based upon the terms of your particular benefit plan. Each

More information

Understanding Leukemia LEUKEMIA LYMPHOMA MYELOMA

Understanding Leukemia LEUKEMIA LYMPHOMA MYELOMA Understanding Leukemia LEUKEMIA LYMPHOMA MYELOMA Introduction This booklet is for anyone interested in learning more about leukemia. It explains the four main types of leukemia, how leukemia is diagnosed,

More information

BL-8040: BEST-IN-CLASS CXCR4 ANTAGONIST FOR TREATMENT OF ONCOLOGICAL MALIGNANCIES

BL-8040: BEST-IN-CLASS CXCR4 ANTAGONIST FOR TREATMENT OF ONCOLOGICAL MALIGNANCIES BL-8040: BEST-IN-CLASS CXCR4 ANTAGONIST FOR TREATMENT OF ONCOLOGICAL MALIGNANCIES Clinical Development Program Prof. Moshe Phillip, MD VP Clinical & Medical Affairs 1 Rationale for BL-8040 Development

More information

Lauren Berger: Why is it so important for patients to get an accurate diagnosis of their blood cancer subtype?

Lauren Berger: Why is it so important for patients to get an accurate diagnosis of their blood cancer subtype? Hello, I m Lauren Berger and I m the Senior Director of Patient Services Programs at The Leukemia & Lymphoma Society. I m pleased to welcome Dr. Rebecca Elstrom. Dr. Elstrom is an Assistant Professor in

More information

Stem Cell Transplantation in Leukemia. D. Niederwieser University of Leipzig Germany

Stem Cell Transplantation in Leukemia. D. Niederwieser University of Leipzig Germany Stem Cell Transplantation in Leukemia D. Niederwieser University of Leipzig Germany probability Stem Cell Transplantation in Acute Myeloid Leukemia Outcome according to cytogenetics AML 96 n = 35, 163,

More information

Acute Myeloid Leukemia- How can we fix it?

Acute Myeloid Leukemia- How can we fix it? Acute Myeloid Leukemia- ow can we fix it? Jeffrey W. Taub, M.D. Division of ematology/ncology Children s ospital of Michigan Wayne State University School of Medicine Detroit, Michigan Proliferation of

More information

Mechanism Of Action of Palbociclib & PFS Benefit

Mechanism Of Action of Palbociclib & PFS Benefit A Phase II Randomized Controlled Trial of Palbociclib & Tamoxifen/Fulvestrant in Postmenopausal Women and Men With Hormone-Receptor Positive, HER2- Negative Metastatic Breast Cancer (MBC) Protocol Chair:

More information

A Network Meta-analysis of Randomized Controlled Trials of Induction Treatments in Acute Myeloid Leukemia in the Elderly

A Network Meta-analysis of Randomized Controlled Trials of Induction Treatments in Acute Myeloid Leukemia in the Elderly Clinical Therapeutics/Volume 33, Number 3, 2011 A Network Meta-analysis of Randomized Controlled Trials of Induction Treatments in Acute Myeloid Leukemia in the Elderly Dimitrios C. Ziogas, MD 1,2 ; Michael

More information

Response Definition, Evaluation and Monitoring. Michele Baccarani

Response Definition, Evaluation and Monitoring. Michele Baccarani Response Definition, Evaluation and Monitoring Michele Baccarani European LeukemiaNet EVOLVING CONCEPTS IN THE MANAGEMENT OF CHRONIC MYELOID LEUKEMIA VENICE 8 9 MAY 2006 Response definition, evaluation

More information

APPROACH TO THE DIAGNOSIS AND TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) Hematology Rounds Thurs July 23, 2009 Carolyn Owen

APPROACH TO THE DIAGNOSIS AND TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) Hematology Rounds Thurs July 23, 2009 Carolyn Owen APPROACH TO THE DIAGNOSIS AND TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) Hematology Rounds Thurs July 23, 2009 Carolyn Owen Outline Diagnosis Prognosis Treatment AML Elderly AML APL Future directions AML

More information

Prior Authorization Guideline

Prior Authorization Guideline Prior Authorization Guideline Guideline: PS Inj - Alimta Therapeutic Class: Antineoplastic Agents Therapeutic Sub-Class: Antifolates Client: PS Inj Approval Date: 8/2/2004 Revision Date: 12/5/2006 I. BENEFIT

More information

ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials)

ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials) ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials) 3 Integrated Trials Testing Targeted Therapy in Early Stage Lung Cancer Part of NCI s Precision Medicine Effort in

More information

IMMUNOMEDICS, INC. February 2016. Advanced Antibody-Based Therapeutics. Oncology Autoimmune Diseases

IMMUNOMEDICS, INC. February 2016. Advanced Antibody-Based Therapeutics. Oncology Autoimmune Diseases IMMUNOMEDICS, INC. Advanced Antibody-Based Therapeutics Oncology Autoimmune Diseases February 2016 Forward-Looking Statements This presentation, in addition to historical information, contains certain

More information

The Clinical Trials Process an educated patient s guide

The Clinical Trials Process an educated patient s guide The Clinical Trials Process an educated patient s guide Gwen L. Nichols, MD Site Head, Oncology Roche TCRC, Translational and Clinical Research Center New York DISCLAIMER I am an employee of Hoffmann-

More information

Clinical Use of Karyotype and Molecular Markers In Curing Acute Myeloid Leukemia

Clinical Use of Karyotype and Molecular Markers In Curing Acute Myeloid Leukemia Clinical Use of Karyotype and Molecular Markers In Curing Acute Myeloid Leukemia Clara D. Bloomfield, M.D. Distinguished University Professor The Ohio State University Comprehensive Cancer Center, and

More information

Clinical guidelines for the management of Acute Myeloid Leukaemia (AML)

Clinical guidelines for the management of Acute Myeloid Leukaemia (AML) Clinical guidelines for the management of Acute Myeloid Leukaemia (AML) Prepared by: Dr Salaheddin Tueger. Countess of Chester Hospital Consultant Haematologist On behalf of the Haematology CNG Revised

More information

Ar Mino changes including adjustment of therapy algorithms

Ar Mino changes including adjustment of therapy algorithms cute Myeloid Leukemia Updated April 2008 by Dr. Richard Wells* Updates: Ar Mino changes including adjustment of therapy algorithms Introduction Acute myeloid leukemia is a relatively uncommon cancer with

More information

Acute Myelogenous Leukemia Pre-HSCT Data

Acute Myelogenous Leukemia Pre-HSCT Data Instructions for Acute Myelogenous Leukemia Pre-HSCT Data (Form 2010) This section of the CIBMTR Forms Instruction Manual is intended to be a resource for completing the AML Pre-HSCT Data Form. E-mail

More information

ACUTE MYELOID LEUKEMIA (AML),

ACUTE MYELOID LEUKEMIA (AML), 1 ACUTE MYELOID LEUKEMIA (AML), ALSO KNOWN AS ACUTE MYELOGENOUS LEUKEMIA WHAT IS CANCER? The body is made up of hundreds of millions of living cells. Normal body cells grow, divide, and die in an orderly

More information

treatments) worked by killing cancerous cells using chemo or radiotherapy. While these techniques can

treatments) worked by killing cancerous cells using chemo or radiotherapy. While these techniques can Shristi Pandey Genomics and Medicine Winter 2011 Prof. Doug Brutlag Chronic Myeloid Leukemia: A look into how genomics is changing the way we treat Cancer. Until the late 1990s, nearly all treatment methods

More information

Outline of thesis and future perspectives.

Outline of thesis and future perspectives. Outline of thesis and future perspectives. This thesis is divided into two different sections. The B- section involves reviews and studies on B- cell non- Hodgkin lymphoma [NHL] and radioimmunotherapy

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy Hematopoietic Stem-Cell Transplantation for CLL and SLL File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem-cell_transplantation_for_cll_and_sll

More information

Population Outcomes of Primary Mediastinal Large B-cell Lymphoma in the Rituximab Era. Karen Ortiz Cruz, MD

Population Outcomes of Primary Mediastinal Large B-cell Lymphoma in the Rituximab Era. Karen Ortiz Cruz, MD Population Outcomes of Primary Mediastinal Large B-cell Lymphoma in the Rituximab Era Karen Ortiz Cruz, MD Introduction Primary Mediastinal Large B-cell Lymphoma (PMLBCL) - a rare entity corresponding

More information

Therapy-related leukemia/myelodysplastic syndrome in multiple myeloma

Therapy-related leukemia/myelodysplastic syndrome in multiple myeloma Therapy-related leukemia/myelodysplastic syndrome in multiple myeloma KAZUHIKO NATORI DAISUK NAGASE SUSUMU ISHIHARA AKIKO YUKITOSHI TOYODA MOTOHIRO KATO YOSINORI FUJIMOTO YASUNOBU KURAISHI HARUKA IZUMI

More information

Acute myeloid leukaemia (AML) in children

Acute myeloid leukaemia (AML) in children 1 61.02 Acute myeloid leukaemia (AML) in children AML can affect children of any age, and girls and boys are equally affected. Leukaemia Acute myeloid leukaemia (AML) FAB classification of AML Causes of

More information

Building A Focused Oncology Business

Building A Focused Oncology Business Building A Focused Oncology Business David Meek President, Oncology Our Strategic Priority: To be at the forefront of patient-centric innovation, bringing life-changing cancer therapies to patients with

More information

FastTest. You ve read the book... ... now test yourself

FastTest. You ve read the book... ... now test yourself FastTest You ve read the book...... now test yourself To ensure you have learned the key points that will improve your patient care, read the authors questions below. Please refer back to relevant sections

More information

Drug/Drug Combination: Bevacizumab in combination with chemotherapy

Drug/Drug Combination: Bevacizumab in combination with chemotherapy AHFS Final Determination of Medical Acceptance: Off-label Use of Bevacizumab in Combination with Chemotherapy for the Treatment of Metastatic Breast Cancer Previously Treated with Cytotoxic Chemotherapy

More information

Acute myeloid leukaemia (AML)

Acute myeloid leukaemia (AML) Acute myeloid leukaemia (AML) For adults and children with blood cancer bloodwise.org.uk Patient information My details This is a place to put important information about you, your condition and key contacts.

More information

Cancer Treatments Subcommittee of PTAC Meeting held 18 September 2015. (minutes for web publishing)

Cancer Treatments Subcommittee of PTAC Meeting held 18 September 2015. (minutes for web publishing) Cancer Treatments Subcommittee of PTAC Meeting held 18 September 2015 (minutes for web publishing) Cancer Treatments Subcommittee minutes are published in accordance with the Terms of Reference for the

More information

National Pharmaceutical Pricing Authority 3 rd Floor, YMCA Cultural Centre 1 Jai Singh Road New Delhi 110001 File No. 23(01)2014/Div.

National Pharmaceutical Pricing Authority 3 rd Floor, YMCA Cultural Centre 1 Jai Singh Road New Delhi 110001 File No. 23(01)2014/Div. Dated 21 st November 2014 NPPA Invites Comments of Pharmaceutical Industry & Trade, Consumer Organisations, Public Health Experts and other Stakeholders on the Recommendations of Tata Memorial Centre under

More information

Daiichi Sankyo to Acquire Ambit Biosciences

Daiichi Sankyo to Acquire Ambit Biosciences For Immediate Release Company name: DAIICHI SANKYO COMPANY, LIMITED Representative: Joji Nakayama, Representative Director, President and CEO (Code no.: 4568, First Section, Tokyo Stock Exchange) Please

More information

1. Acute Myeloid Leukaemia Hyper-CVAD/MA. Indication

1. Acute Myeloid Leukaemia Hyper-CVAD/MA. Indication 1. Acute Myeloid Leukaemia 1.13 Hyper-CVAD/MA Indication Mantle-cell lymphoma (diffuse, nodular or blastic variants). Hyper-CVAD/MA has also been used in adult B-cell Acute Lymphoblastic Leukaemia. Relapsed

More information

Postmarket Surveillance -Adverse Event Reporting in the Office of Generic Drugs

Postmarket Surveillance -Adverse Event Reporting in the Office of Generic Drugs Postmarket Surveillance -Adverse Event Reporting in the Office of Generic Drugs Integration Communication Collaboration John R Peters, MD Director, Division of Clinical Review Office of Generic Drugs 1

More information

Ovarian Cancer and Modern Immunotherapy: Regulatory Strategies for Drug Development

Ovarian Cancer and Modern Immunotherapy: Regulatory Strategies for Drug Development Ovarian Cancer and Modern Immunotherapy: Regulatory Strategies for Drug Development Sanjeeve Bala, MD, MPH Ovarian Cancer Endpoints Workshop FDA White Oak September 3, 2015 Overview Immune agents from

More information

Effect of liraglutide on body weight in overweight or obese subjects with type 2 diabetes: SCALE - Diabetes

Effect of liraglutide on body weight in overweight or obese subjects with type 2 diabetes: SCALE - Diabetes Effect of liraglutide on body weight in overweight or obese subjects with type 2 diabetes: SCALE - Diabetes This trial is conducted in Africa, Asia, Europe and the United States of America (USA). The aim

More information

Brief Communications. Awad Mohamed Ahmed, MD. Abstract

Brief Communications. Awad Mohamed Ahmed, MD. Abstract Awad Mohamed Ahmed, MD Professor of Medicine, University of Bahr Elghazal, Khartoum, Sudan For correspondence Professor Awad Mohamed Ahmed E-mail: awad.sd@gmail.com Tel.: +249 912344936 Abstract Randomized

More information

Acute Promyelocytic Leukemia

Acute Promyelocytic Leukemia PATIENT RESOURCE CANCER GUIDE Acute Promyelocytic Leukemia Take Control Phases of Treatment Available Resources & Clinical Trial Research Reviewed by a Distinguished Medical Advisory Board PatientResource.com

More information

Acute Lymphoblastic Leukemia in Children A Brief Review of the Internationally Available Protocols

Acute Lymphoblastic Leukemia in Children A Brief Review of the Internationally Available Protocols Second Meeting of the Subcommittee of the Expert Committee on the Selection and Use of Essential Medicines Geneva, 29 September to 3 October 2008 Acute Lymphoblastic Leukemia in Children A Brief Review

More information

Management of low grade glioma s: update on recent trials

Management of low grade glioma s: update on recent trials Management of low grade glioma s: update on recent trials M.J. van den Bent The Brain Tumor Center at Erasmus MC Cancer Center Rotterdam, the Netherlands Low grades Female, born 1976 1 st seizure 2005,

More information

National Cancer Institute Research on Childhood Cancers. In the United States in 2005, approximately 9,510 children under age 15 will be

National Cancer Institute Research on Childhood Cancers. In the United States in 2005, approximately 9,510 children under age 15 will be CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s National Cancer Institute

More information

January 2013 LONDON CANCER NEW DRUGS GROUP RAPID REVIEW. Summary. Contents

January 2013 LONDON CANCER NEW DRUGS GROUP RAPID REVIEW. Summary. Contents LONDON CANCER NEW DRUGS GROUP RAPID REVIEW Paclitaxel albumin (Abraxane ) as a substitute for docetaxel/paclitaxel for cancer Paclitaxel albumin (Abraxane ) as a substitute for docetaxel/ paclitaxel for

More information

GRANIX (tbo-filgrastim)

GRANIX (tbo-filgrastim) RATIONALE FOR INCLUSION IN PA PROGRAM Background Neutropenia is a hematological disorder characterized by an abnormally low number of neutrophils. A person with severe neutropenia has an absolute neutrophil

More information

PHASE I CLINICAL TRIALS

PHASE I CLINICAL TRIALS PHASE I CLINICAL TRIALS GOALS Phases of Clinical Trials Unique aspects of Phase I Trials Benefits and Barriers to enrollment PHASE 3 CLINICAL TRIAL Purpose: To compare the new treatment with the current

More information

Clinical Research Program Information for Patients. Transplant Creations

Clinical Research Program Information for Patients. Transplant Creations Clinical Research Program Information for Patients Transplant Creations 1 Program Focus Combination chemotherapy and transplantation of stem cells from an autologous donor (patient s own stem cells) and/or

More information

Secondary hematologic malignancies after chemotherapy. Sasha Stanton MD PhD February 14, 2014 Dr. Tony Blau Discussant

Secondary hematologic malignancies after chemotherapy. Sasha Stanton MD PhD February 14, 2014 Dr. Tony Blau Discussant Secondary hematologic malignancies after chemotherapy Sasha Stanton MD PhD February 14, 2014 Dr. Tony Blau Discussant Case 1 Referral from Dr. Blau (Sibel) of a 60 yo woman 3 years out of therapy for her

More information

Immunomodulatory drugs in the treatment of Multiple Myeloma: focus on maintenance treatment. Pr Philippe Moreau University Hospital, Nantes, France

Immunomodulatory drugs in the treatment of Multiple Myeloma: focus on maintenance treatment. Pr Philippe Moreau University Hospital, Nantes, France Immunomodulatory drugs in the treatment of Multiple Myeloma: focus on maintenance treatment Pr Philippe Moreau University Hospital, Nantes, France Maintenance therapy is applied for a prolonged period

More information

Original Article Treatment of older patients with acute myeloid leukemia (AML): a Canadian consensus

Original Article Treatment of older patients with acute myeloid leukemia (AML): a Canadian consensus Am J Blood Res 2013;3(2):141-164 www.ajblood.us /ISSN:2160-1992/AJBR1301001 Original Article Treatment of older patients with acute myeloid leukemia (AML): a Canadian consensus Joseph M Brandwein 1, Michelle

More information

Avastin in Metastatic Breast Cancer

Avastin in Metastatic Breast Cancer Non-interventional study Avastin in Metastatic Breast Cancer ML 21165 / 2007 Clinical Study Report Synopsis ROCHE ML21165 / WiSP Project RH09 / V. 1.0 / 24.06.2013 ROCHE ML21165-2 - Name of Sponsor Roche

More information

AML- new studies. Moderator Prof. Edo Vellenga. 1st author / speaker Mojca Jongen-Lavrencic

AML- new studies. Moderator Prof. Edo Vellenga. 1st author / speaker Mojca Jongen-Lavrencic AML- new studies Moderator Prof. Edo Vellenga 1st author / speaker Mojca Jongen-Lavrencic Belangenverklaring In overeenstemming met de regels van de Inspectie van de Gezondheidszorg (IGZ) Naam: Organisatie:

More information