and MAXON TM CV synthetic absorbable sutures are prepared from polyglyconate, a copolymer of glycolic acid and trimethylene carbonate.

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1 T A X O N T A X O N

2 Description Characteristics Indications Contraindications Actions Tensile Strength Absorption Sterilization Packaging and CV synthetic absorbable sutures are prepared from polyglyconate, a copolymer of glycolic acid and trimethylene carbonate. The advanced extrusion process of the molecule of polyglyconate gives the suture: Excellent in-vivo strength retention Excellent knot tying security Excellent handling inimal memory and CV synthetic absorbable sutures are indicated for use in general soft tissue approximation and/or ligation, including use in pediatric cardiovascular tissue, where growth is expected to occur, and in peripheral vascular surgery. and CV synthetic absorbable sutures are not indicated for use in adult cardiovascular tissue, ophthalmic surgery, microsurgery and neural tissues. The use of this suture is contraindicated in patients with known sensitivities or allergies to its components. These sutures, being absorbable, should not be used where extended approximation of tissue is required or for fixation of permanent cardiovascular prostheses or synthetic grafts. and CV synthetic absorbable sutures elicit a minimal acute inflammatory reaction in tissues, followed by gradual encapsulation of the suture by fibrous connective tissue. Progressive loss of tensile strength and eventual absorption of sutures occurs by means of hydrolysis. Experimental studies with and CV suture produced no evidence of antigenicity, systemic toxicity, carcinogenicity, mutagenicity teratogenicity or adverse effects on reproductive performance. Subcutaneous tissue implantation studies in rats indicate sutures retain approximately 75% of initial tensile strength at two weeks, 65% of at three weeks and 50% at four weeks post-implant. Absorption begins as a loss of tensile strength without appreciable loss of mass. Absorption of sutures is minimal until about 60 days after implant and is essentially complete within six months. Ethylene oxide sutures are available in and EP sizes 2 (5 metric) through 7-0 (0.5 metric). CV sutures are available only in and EP sizes 7-0 (0.5 metric) through 4-0 (1.5 metric). and CV sutures are dyed with D&C Green No. 6. sutures are available undyed (clear). The sutures are supplied sterile, in pre-cut lengths; non-needled or affixed to various needle types, using both permanent and removable needle attachment techniques; in one, two or three dozen boxes.

3 NON-NEEDLE PRODUCTS PRE-CUT 5 3x18 Green x18 Green REVERSE CUTTING 19 mm 18 Clear Clear Green C mm 30 Clear Green C mm 30 Clear C mm 5x18 Green Clear Green GS-10 DERAX SURGALLOY Removable needles SAm-1

4 REVERSE CUTTING 30 Green GS mm 30 Green Green GS mm 30 Green HOS Green HOS mm 5x18 Green Green HOS-12 SAm-2 DERAX SURGALLOY Removable needles

5 PREIU REVERSE CUTTING 11 mm 18 Clear Green P mm 18 Clear 36 S-5516 S-5526 S Green 36 S-5539 P mm 18 Clear 36 S-5221 S-5431 P mm 18 Green 36 S-5033 S Clear 36 S-5042 S-5043 S Clear 36 S-5323 P mm 18 Clear 36 S-5231 S-5241 P-14 DERAX SURGALLOY Removable needles SAm-3

6 PREIU X-CUTTING 11 mm 18 Clear 12 XX-489 DX mm 18 Clear 12 XX-833 DX mm 18 Clear 12 XX-844 XX-845 DX mm 18 Clear 12 XX-823 XX-824 DX-19 PREIU REVERSE CUTTING 9 mm 18 Clear P mm 18 Clear 36 S-5831 P-24 SAm-4 DERAX SURGALLOY Removable needles

7 CUTTING Straight 60 mm 30 Clear SC-2 Straight 254 mm 30 Green SC-250 SC-250 TAPER POINT 9 mm 18 Green Green x24 Green Green CV-1 11 mm 18 Green CV 13 mm 18 Green Green x24 Green Green Green CV-11 DERAX SURGALLOY Removable needles SAm-5

8 TAPER POINT 13 mm 24 Green Green CV mm 5x18 Green Green CV mm 30 Green Green CV mm 30 Green CV mm 5x18 Green Green CV-24 SAm-6 DERAX SURGALLOY Removable needles

9 TAPER POINT 27 mm 5x18 Green Green GS-22 5x18 Green Green x30 Green Clear Green GS mm 5x18 Green Green Green GS mm Green GS mm 5x18 Green Green Green Green GS-25 DERAX SURGALLOY Removable needles SAm-7

10 TAPER POINT 65 mm Green Green GS mm 2x30 Green Clear Green GS mm 30 Green GS mm 30 Green HGS Green HGS-21 SAm-8 DERAX SURGALLOY Removable needles

11 TAPER POINT 26 mm 5x18 Green Clear Green V mm 36 Green Green Green V Green V-26 5/8 Circle 27 mm 18 Green Green HGU-46 DERAX SURGALLOY Removable needles SAm-9

12 TAPER POINT Straight 19 mm 18 Green ST-4 Straight 60 mm 30 Green ST BLUNT TAPER POINT 5x18 Green Green BGS mm 36 Green BGS mm 36 Green BGS-25 SAm-10 DERAX SURGALLOY Removable needles

13 BLUNT TAPER POINT 65 mm 60 Green BGS Green HBGS-21 DERAX SURGALLOY Removable needles SAm-11

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