THE PREVALENCE OF sleep disorders among

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1 Psychiatry and Clinical Neurosciences 2014 doi: /pcn Regular Article Methodological challenges in studies of bright light therapy to treat sleep disorders in nursing home residents with dementia Eva S. van der Ploeg, PhD and Daniel W. O Connor, MD, FRANZCP* School of Psychology and Psychiatry, Monash University, Melbourne, Australia Aim: Numerous studies have explored the effectiveness of bright light therapy as a treatment of sleep disorders in nursing home and long-stay geriatric hospital residents, most of whom have dementia. A recent Cochrane Collaboration meta-analysis of 10 selected studies concluded that there was insufficient evidence to assess its therapeutic efficacy as most available studies had methodological problems. We sought to remedy this situation by developing proposals to guide research methods in future studies. Methods: Based on the literature and our own clinical and research experience, we developed a series of proposals relating to study design, participant selection, light delivery modalities and outcome measures that we believe will maximize the chances of identifying a bright light treatment effect. We then checked adherence to these proposals in all relevant published experimental studies. Results: Of the 18 studies published in the last two decades that met our selection criteria, only half the studies had selected participants with a sleep disorder. Eleven studies excluded people with severe vision loss; seven included a clinical rating of sleep, and five measured baseline lighting levels. Most checked psychoactive medication prescriptions but few reported changes in prescriptions over the course of the study. Most also checked treatment adherence and included some control for differences in amount of social contact. Conclusions: Evidence for the effectiveness of bright white light treatment in people residing in nursing homes is equivocal. We anticipate that the quality of this evidence will be improved if researchers refine their study methods and adopt a more uniform approach. Key words: dementia, nursing homes, phototherapy, research design, sleep disorder. THE PREVALENCE OF sleep disorders among nursing home residents, most of whom have dementia, varies from 40% to 70% depending on the definitions used. 1 These disorders which can include difficulty initiating or resuming sleep, waking during the night or waking too early, feeling unrefreshed upon waking and daytime sleepiness compromise both subjective and objective physical *Correspondence: Daniel W. O Connor, MD, FRANZCP, Aged Mental Health Research Unit, Kingston Centre, Warrigal Road, Cheltenham, VIC 3192, Australia. daniel.oconnor@monash.edu Received 27 September 2013; revised 28 January 2014; accepted 11 April and mental health and have been associated with cognitive deficits, cardiovascular and respiratory problems, endocrine dysfunction, impaired immunity, accidents, falls, pain, depression and anxiety. 2,3 Age-related cognitive decline may be due in part to poor sleep 4 and nocturnal awakenings in people with dementia might contribute to daytime agitation and accelerate cognitive and functional deterioration. 5 Sleep disruptions may result from fragmentation of the circadian rhythms that underpin many physiological processes and behaviors. Under normal circumstances, these rhythms are synchronized to 24-h cyclic patterns in the external environment, known as time cues or Zeitgebers. Light is the most powerful time cue and exposure to a robust 24-h light dark 1

2 2 E. S. van der Ploeg and D. W. O Connor Psychiatry and Clinical Neurosciences 2014 cycle is required to maintain appropriate circadian entrainment. The circadian pacemaker is located in the hypothalamic suprachiasmatic nuclei (SCN), which send multiple efferent signals to other brain areas to synchronize physiological, metabolic and behavioral functions. 6 With ageing, there is a reduction in SCN cell numbers and neuronal activity, resulting in a loss of the robustness of circadian rhythms as shown by a lower oscillation amplitude and reduced sensitivity to Zeitgebers, particularly light. 7 SCN neurons might simply become inactive, rather than defunct, as studies of aged rats found that exposure to bright light appeared to reverse agerelated circadian rhythm disturbances 8 and prevent age-related reductions in the numbers of vasopressinsecreting cells. 9 The same mechanisms might operate in humans. Other factors that could contribute to the breakdown of 24-h sleep wake rhythms in older people include: (i) reduced exposure to light dark cycles because of physical immobility and restricted access to daylight; 10 (ii) intrinsic changes in optical, photoreceptor and neuronal functioning leading to a diminished retinal sensitivity to light; 11 (iii) yellowing of the lens; 12 and (iv) a smaller pupil diameter meaning that less light is transmitted to the retina. 13 People aged over 75 years retain only 20% of a 10-year-old child s photoreceptive capacity and therefore require 5 times brighter light to maintain optimal circadian rhythms. 13 Generally speaking, the elderly need more and brighter light to reset their circadian rhythms but, once admitted to nursing homes and other long-stay settings, their exposure to light is often reduced. As an example, in 29 Japanese aged-care facilities, the average light intensity was 300 lux by day and 200 lux at night, 14 blurring differences between day and night. In Belgium, lighting levels in eight nursing homes met national standards in only one of the homes on sunny days and in none on cloudy days. 15 Similarly, 77 aged-care residents in a US study had a median daytime light exposure of only 52 lux. 16 Numerous studies have explored the effectiveness of bright light therapy to strengthen the circadian rhythm and improve sleep patterns in older people in nursing homes and long-stay hospital wards. Bright white light has been delivered either by seating participants in front of a light box or by substituting standard wall or ceiling light fittings with bright light tubes in selected areas. The intensity of the light intervention varied greatly between studies. The results have been mixed and a Cochrane Collaboration meta-analysis of 10 reports that met strict inclusion criteria concluded that there was insufficient evidence to assess the value of light therapy for people with dementia as too few of the studies were of high methodological quality. 17 In contrast to the Cochrane review, which synthesized the results of a small number of randomized controlled trials, we set out to enumerate the methods employed in studies of the effects of bright light therapy on the sleep patterns of aged residents of nursing homes and long-stay hospitals. Prior to conducting the review, we developed a series of recommendations regarding study design features that might, we believe, maximize researchers chances of detecting the benefits of bright light treatment, assuming that such benefits exist. These recommendations were then mapped against the methods employed in studies that met basic inclusion criteria with the goal of promoting discussion and encouraging a greater uniformity of approach in future studies. We chose not to focus on elements like randomization and blinding that are addressed in standard checklists of clinical trial integrity but to concentrate instead on issues particular to the study of sleep disorders in people with dementia. METHODS Selection of studies To qualify for inclusion in the review, experimental studies were required to have: (i) been published in English; and (ii) tested bright light using a light box, wall- or ceiling-mounted lighting installations, or outdoor light in (iii) a long-term care setting where all, or almost all, participants had dementia, (v) using a rating or measure of activity, rest or sleep, with (vi) statistical analyses that (vii) partialled out the benefits of bright light therapy in the event that more than one intervention was tested. After a search of PubMed and EMBASE literature databases using the terms ( aged or nursing homes ) and ( circadian rhythm or sleep disorder ) and humans and phototherapy, followed by checks of references from earlier reviews, 24 studies appeared to meet the stated criteria. Of these, six reports were excluded for the following reasons: two presented preliminary data that were described in greater detail elsewhere; 18,19 two included no statistical analyses; 20,21 one tested low intensity dawn dusk simula-

3 Psychiatry and Clinical Neurosciences 2014 Bright light therapy in nursing homes 3 tion; 22 and one was conducted in a non-residential setting. 23 This left 18 papers for consideration, only six of which had also been included in the Cochrane meta-analysis Methodological proposals We developed a series of recommendations drawn from the literature and our own clinical and research experience that we hope will maximize researchers chances of detecting treatment effects. These proposals concern the selection of study participants, treatment delivery modalities and outcome measurement. Both authors checked each of the selected reports and noted whether the eight recommended strategies had or had not been included in the methodology. If a clinical characteristic or strategy was not mentioned explicitly, it was rated as absent or not done. 1. Study sample 1a. Dementia Bright light therapy could be of benefit to many nursing home residents but interest to date has focused on those with dementia given the association between dementia and sleep and behavioral disorders. It is advisable therefore to confirm the diagnosis of dementia using an internationally accepted glossary. In studies in which all residents of a facility are exposed to an intervention, for example ceilingmounted bright lights, cognitive function and dementia diagnoses should be mapped to ascertain their associations with treatment outcomes. acuity in people with advanced dementia is sometimes difficult. As a minimum safeguard, people known to have an ophthalmic abnormality that greatly impedes light perception (e.g. dense bilateral cataracts) should be excluded from studies. 1d. Psychoactive medication checks Medications including antipsychotics, antidepressants and benzodiazepines are commonly prescribed in nursing homes to relieve agitation and improve mood. 30 Many of these medications are sedative and changes in prescribing patterns during the course of a study, or the use of medications on an occasional basis, may confound the results, especially in studies that last for several weeks. Researchers should therefore exclude residents with unstable psychotropic dosing regimens and report changes in medications over the course of the study. 2. Treatment design 2a. Baseline lighting To induce clinically significant change, an intervention should increase the amount, intensity and/or duration of available light. While lighting levels are often low, conditions in summer months in the southern hemisphere, for example, may be very different from those in winter in the northern hemisphere. Available light levels should be measured, therefore, in the parts of the residence or ward where participants spend most time and at the time of day when treatment is actually delivered. 1b. Sleep disorder To show that bright light therapy leads to improved sleep quantity and/or quality, participants in clinical trials should have some pre-existing sleep disorder, such as delayed sleep onset, multiple awakenings or daytime sleepiness. While dementia is often accompanied by changes in the rest activity cycle, they may not always be clinically significant. If there is no problem to solve, no treatment can be shown to be effective. 1c. Vision loss For bright light therapy to reset the rest activity cycle, it is critical that light reaches the retina. 10 Participants should be able to perceive light but measuring visual 2b. Adherence checks Individuals with severe dementia are at risk of agitated behaviors like incessant pacing. These behaviors will interfere with treatment protocols if participants cannot remain still in front of a light source for the specified periods, usually 1 2 h. Researchers should therefore ensure adherence to treatment protocols. Adherence might also be an issue in studies of wallor ceiling-mounted light fittings if participants repeatedly leave the treatment area or spend much of their day elsewhere. 2c. Control condition If light therapy is administered or supervised by a nurse or researcher, their presence close to partici-

4 4 E. S. van der Ploeg and D. W. O Connor Psychiatry and Clinical Neurosciences 2014 pants can help shape the outcome. In the case of people with dementia, social contact greatly reduces levels of motor agitation and promotes better quality sleep, 1,31 making it necessary to employ a control condition that tests another type of light or offers an equivalent amount of social interaction. This may not be an issue in studies of wall- or ceiling-mounted light fixtures where no special supervision is required (though the times spent in brightly lit areas should still be recorded). 3. Outcome measures 3a. Measures Sleep is best assessed outside laboratories through a combination of clinical observations and actigraphic monitors that detect the occurrence and degree of movement-induced acceleration. 32 Nurses tend to overestimate sleep time while actigraphy, when used alone, cannot discern if a participant is sleeping or just sitting or lying quietly. 33 This is a particular issue for physically incapacitated residents who spend most of the day sitting in a chair. It is desirable, therefore, to combine actigraphy with a clinical rating of sleep when assessing daytime and night-time sleeping patterns. RESULTS The selected studies are summarized in Table 1. 5,25 29,34 44 In addition to basic details (study type, participant numbers, light source, light intensity, treatment duration), the Table shows if researchers had specified: (1b) the presence of a sleep disorder of any type, determined by any means; (1c) if people with severe vision loss were excluded; (1d) checks of psychoactive medications; (2a) baseline light levels; (2b) a check of treatment adherence; (2c) some means to control for participant researcher interaction where this was not held constant across study arms; and (3) the use of observational and/or actigraphic outcome measures. Finally, the Table indicates if sleep was significantly improved in the bright light condition relative to baseline or the control condition. The 18 selected studies were conducted in five countries with eight from the USA, five from Japan, two from the Netherlands, two from Norway and one from the UK. All were published in the last two decades. Eight studies had employed a before after design comparing bright light with usual light levels; seven were randomized controlled trials, and three used a cross-over design in which participants were switched from one experimental condition to another in random order. Two studies added sleep hygiene 34 and melatonin to the treatment condition 29 and two others used multiple experimental arms to test for any additional, independent effects on sleep of melatonin 26 and vitamin B With respect to other conditions of interest, one study also focused on neuropsychiatric symptoms, cognition and activities of daily living. 29 Other studies also focused on agitation, 27,36,37 mood, 27 and cognition. 38 The number of participants per study ranged from 10 to 189 with a mean of Five studies were very small with fewer than 20 participants. In the largest study, standard ceiling light fittings were replaced with bright lights with the aim of irradiating large areas within the nursing homes for many hours each day. The study ran for over 2 years but participant numbers declined steadily over this period, falling from 189 to The bright light treatments varied in intensity from 1000 to lux with a mean of about 4400 lux. The levels emanating from wall- or ceiling-mounted fittings were typically lower than those from light boxes with a mean of about 2700 lux when measured near participants faces. 5 Bright lights were applied for 1 h or less daily in six studies; for 2 h daily in nine studies; for between 4 and 13 h in different arms in one study, and for all or most of the day and evening in two. Treatment was applied in the morning in 11 studies; in the evening in one study, in the morning or evening or both in different arms in four studies and throughout the day using wall- or ceiling-mounted fixtures in two. With respect to the recommended strategies, 10 of the 18 studies selected participants on the basis of disordered sleep patterns. One required a degree of agitation but made no reference to sleep disorder 27 and seven required neither. Criteria were mostly couched in general terms, such as various sleep disturbances. 39 One study required sleep disruption at least two nights per week 36 and the conditions themselves were specified in more detail in two others, for example, frequent night-time awakenings, wandering at night, unusually early morning awakenings, sundowning and excessive daytime sleepiness. 25 Only one study required participants to have delayed

5 Psychiatry and Clinical Neurosciences 2014 Bright light therapy in nursing homes 5 Table 1. Details of studies and adherence to recommended methods Study type Participants numbers Light source Mean light (lux) Study length (weeks) Hours of light/day Ancoli-Israel (2002) 41 R 77 B M,E No Ancoli-Israel (2003) 24 R 63 B M,E No Burns (2009) 36 R 48 B M Yes Dowling (2005) 25 R 70 I M,E Yes Dowling (2008) 26 R 50 B + O ± M M Yes Fetveit (2003) 35 B 11 B M Yes Ito (2001) 42 B 28 B M No Kobayashi (2001) 39 B 10 I M Yes Lyketsos (1999) 27 X 15 B M No Martin (2007) 34 R 108 O + H > M Yes Mishima (1994) 44 B 24 B M Yes Mishima (1998) 28 X 22 B M Yes Riemersma (2008) 29 R 189 I All All No Satlin (1992) 40 B 10 B E Yes Skjevre (2004) 37 B 11 B M Yes Sloane (2007) 43 X 66 I M,E,All No Van Someren (1997) 5 B 22 I All All No Yamadera (2000) 38 B 27 B M No 1c: Excluded severe vision loss 1d: Medication reported 2a: Baseline light measured 2b: Adherence checked 2c: Social contact constant or controlled 3: Outcome measure Activity rest change Time of day Comment 1b: Sleep disorder Ancoli-Israel (2002) 41 Yes No No Yes Yes A No Ancoli-Israel (2003) 24 Yes No No Yes Yes A Yes Activity rest cycle consolidated Burns (2009) 36 Yes Yes No Yes Yes A + R No Dowling (2005) 25 Yes Yes Yes Yes Yes A Yes More stable acrophase Dowling (2008) 26 Yes Yes Yes Yes Yes A Yes Less day sleep (melatonin only) Fetveit (2003) 35 No Yes No No Yes A + R Yes More night sleep; less day sleep Ito (2001) 42 No Yes No No No A No Kobayashi (2001) 39 No Yes No Yes Yes A Yes Less day sleep Lyketsos (1999) 27 Yes Yes No Yes Yes R No Martin (2007) 34 No Yes Yes Yes No A Yes More day activity Mishima (1994) 44 No Yes No Yes Yes R Yes More night sleep; less day sleep Mishima (1998) 28 No Yes No No No A Yes More night sleep (vascular dementia only) Riemersma (2008) 29 Yes Yes Yes Yes Yes A Yes Less night sleep Satlin (1992) 40 Yes Yes No Yes No A + R Yes More night sleep; less day sleep Skjevre (2004) 37 Yes Yes No Yes No A + R Yes Advanced acrophase Sloane (2007) 43 Yes No No Yes Yes A + R Yes More night sleep (with morning and all-day light) Van Someren (1997) 5 Yes Yes Yes No Yes A Yes More stable activity rest cycle Yamadera (2000) 38 No Yes No No No A Yes More night sleep; less day sleep Study type: R, randomized; X, cross-over; B, before-after. Light source: B, box; I, ceiling or wall installation; O, outdoors. Other treatments: H, sleep hygiene; M, melatonin. Time of day: M, morning; E, evening. Outcome measure: A, actigraphy; R, sleep rating.

6 6 E. S. van der Ploeg and D. W. O Connor Psychiatry and Clinical Neurosciences 2014 sleep latency and subsequent periods of wakefulness verified using actigraphy. 35 People with severe vision loss were excluded in 11 of the 18 studies. Exclusion criteria included cataracts ; 36 substantial cataracts ; 40 cloudy optical media ; 24 moderate to severe visual impairment ; 37 severe visual impairment ; 41 an inability to perceive light 25 and blindness. 27 Fifteen reports made some reference to the numbers of participants taking psychoactive medications at treatment outset but only four mentioned changes in prescriptions over the course of the study. 29,37,40,42 Only five reports included measures of baseline lighting levels in the study settings. Treatment adherence was promoted in eight of the 12 light box studies, usually by an attending nurse. In studies of wall or ceiling installations, checks of attendance in specially lit areas were recorded in three of the five cases. 25,39,43 In the remaining two studies, common living areas were brightly illuminated for the whole of the day and the researchers assumed that participants spent most of their time there. 5,29 To minimize differences in the levels of social contact, control conditions were employed in five of the 12 light box studies in the form of a dim or dimmer light, 24,41,44 a standard light, 36 and a blinking light. 27 In the light installation studies, participants were free to move about and their social contacts and participation in activities were judged to be similar in the experimental and control conditions, making it unnecessary to control for differences. With respect to outcome measures, 11 studies relied on actigraphic recordings alone; two used some sort of clinical observation, and five used a combination of actigraphy and observation. The observations were mostly described just as sleep charts or sleep logs. In two studies, nurses completed simple sleep wake scales. 37,43 Frequencies and intervals were typically not reported. Outcomes were mostly positive. In four studies, rest activity cycles were described as consolidated or stabilized based on actigraphic recordings. Participants were judged to have slept more, or been less active, at night in six studies and to have slept less, or been more active, during the day in five studies. Night-time sleep was reduced relative to baseline actigraphic recordings in one of the lighting installation studies. 29 Differences were mostly very modest. However, in one light box study, the proportion of total daily activity occurring between hours and hours fell from 18.4% on average in the baseline week to 11.6% in the intervention week. 40 In another light box study, there were 18.1 awakenings per night during the baseline week compared with an average of 13.9 during the 4-week intervention period. 38 DISCUSSION There is certainly some evidence that bright lighting improves sleep in nursing home and long-stay hospital ward residents with dementia but the evidence is contradictory and incomplete. For example, of the studies that had applied five or more of our eight suggested methodological strategies, two had negative results 29,36 while three reported improvements in actigraphic rest activity patterns. 26,37,40 This lack of consistent evidence helps to explain why bright light therapy has not been adopted as a mainstream treatment of sleep disorders in people with dementia, notwithstanding the prevalence of these conditions and their onerous consequences for caregivers. Light boxes require constant staff supervision in the case of residents who are mobile and physically agitated and this adds greatly to the treatment s expense. 5 It is unlikely, therefore, that residential facilities will invest in their use until the evidence base is more persuasive. It might be helpful if future researchers remedied some of the methodological shortcomings identified in this paper. If bright light therapy is conceptualized as a treatment of frequent night-time awakenings and nocturnal restlessness, for example, it makes sense to choose participants with these problems but only half the studies completed to date have done so. Doses of psychoactive medications were mostly held constant but just over half used actigraphy as the sole measure of daytime and night-time activity where inactivity is presumed to represent sleep, perhaps incorrectly. Inserting special bright light tubes into the existing wall- and ceiling-mounted fixtures of nursing homes and long-stay hospital wards may provide an affordable, practicable solution to bringing greater illumination to many residents simultaneously, provided they spend time in the specially lit areas. Bright lights are acceptable to staff, have no clear adverse effects 29 and have the added potential benefits of improving mood and preventing falls. 15 While it is difficult to reach gaze levels of 2500 lux, the accepted intensity

7 Psychiatry and Clinical Neurosciences 2014 Bright light therapy in nursing homes 7 for treatment of seasonal affective disorder, this can certainly be achieved. 43 In any case, the lights are left on all day and the cumulative daily dose is actually very high. 5 This treatment modality warrants further investigation. There is no certainty that the results of further studies will be favorable but a more uniform methodology should prove helpful and assist in subsequent meta-analyses. We cannot demonstrate that our recommended strategies will boost the chances of uncovering a true treatment effect but our proposals will, we hope, provide material for discussion within the research community. ACKNOWLEDGMENTS The authors have no conflict of interest to report. REFERENCES 1. Garms-Homolovà V, Flick U, Rohnsch G. Sleep disorders and activities in long term care facilities A vicious cycle? J. Health Psychol. 2010; 15: Foley D, Monjan A, Brown S, Simonsick EM, Wallace RB, Blazer DG. Sleep complaints among elderly persons: An epidemiological study of three communities. Sleep 1995; 18: Neikrug AB, Ancoli-Israel S. Sleep disorders in the older adult a mini review. Gerontology 2010; 56: Altena E, Ramautar JR, van der Werf YD, van Someren EJW. Do sleep complaints contribute to age-related cognitive decline? Prog. Brain Res. 2010; 185: Van Someren EJW, Kessler A, Mirmiran M, Swaab DF. Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients. Biol. Psychiatry 1997; 41: Lockley SW. Circadian rhythms: Influence of light on humans. In: Binder MD, Horokawa N, Windhorst U (eds). Encyclopedia of Neuroscience. Springer, New York, 2009; Hu K, van Someren EJW, Shea SA, Scheer FAJL. Reduction of scale invariance of activity fluctuations with aging and Alzheimer s disease: Involvement of the circadian pacemaker. Proc. Natl Acad. Sci. U.S.A. 2009; 106: Witting W, Mirmiran M, Bos NP, Swaab DF. Effect of light intensity on diurnal sleep-wake distribution in young and old rats. Brain Res. Bull. 1993; 30: Lucassen PJ, Hofman MA, Swaab DF. Increased light intensity prevents the age-related loss of vasopressinexpressing neurons in the rat suprachiasmatic nucleus. Brain Res. 1995; 693: Van Someren EJW, Riemersma RF, Swaab DF. Functional plasticity of the circadian timing system in old age: Light exposure. Prog. Brain Res. 2002; 138: Freund PR, Watson J, Gilmour GS, Gaillaird F, Sauvé Y. Differential changes in retina function with normal aging in humans. Doc. Ophthalmol. 2011; 122: Giménez MC, Kanis MJ, Beersma DGM, van der Pol BAE, van Norren D, Gordijn MCM. In vivo quantification of the retinal reflectance spectral composition in elderly subjects before and after cataract surgery: Implications for the nonvisual effects of light. J Biol Rhythm 2010; 25: Turner PL, Van Someren EJW, Mainster MA. The role of environmental light in sleep and health: Effects of ocular aging and cataract surgery. Sleep Med. Rev. 2010; 14: Morita T, Tokura H. The influence of different wavelengths of light on human biological rhythms. App. Hum. Sci. 1998; 17: De Lepeleire J, Bouwen A, De Coninck L, Buntinx F. Insufficient lighting in nursing homes. J. Am. Med. Dir. Assoc. 2007; 8: Shocat T, Martin J, Marler M, Ancoli-Israel S. Illumination levels in nursing home patients: Effects on sleep and activity rhythms. J. Sleep Res. 2000; 9: Forbes D, Culum I, Lischka AR et al. Light therapy for managing cognitive, sleep and functional, behavioural, or psychiatric disturbances in dementia. Cochrane DB Syst. Rev. 2009; 4: Dowling GA, Hubbard EM, Mastick J, Luxenberg JS, Burr RL, van Someren EJW. Effect of morning bright light treatment for rest-activity disruption in institutionalized patients with severe Alzheimer s disease. Int. Psychogeriatr. 2005; 17: Okawa M, Mishima K, Hozumi S. Effects of environmental stimulation with bright light and transcranial electrostimulation on sleep and behavior disorders in elderly patients with dementia. In: Iqbal K, Swaab D, Windblad B, Wisniewski H (eds). Alzheimer s Disease and Related Disorders. John Wiley, Toronto, 1999; Fukuda N, Kobayashi R, Kohsaka M et al. Effects of bright light at lunchtime on sleep in patients in a geriatric hospital II. Psychiatry Clin. Neurosci. 2001; 55: Koyama E, Matsubara H, Nakano T. Bright light treatment for sleep-wake disturbances in aged individuals with dementia. Psychiatry Clin. Neurosci. 1999; 53: Gasio PF, Kräuchi K, Cajochen C et al. Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderly. Exp. Gerontol. 2010; 38: Colenda CC, Cohen W, McCall WV, Rosenquist PB. Phototherapy for patients with Alzheimer disease with disturbed sleep patterns: Results of a community-based pilot study. Alzheimer Dis. Assoc. Dis. 1997; 11: Ancoli-Israel S, Gehrman P, Martin JL et al. Increased light exposure consolidates sleep and strengthens circadian rhythms in severe Alzheimer s disease patients. Behav. Sleep Med. 2003; 1:

8 8 E. S. van der Ploeg and D. W. O Connor Psychiatry and Clinical Neurosciences Dowling GA, Mastick J, Hubbard EM, Luxenberg JS, Burr RL. Effect of timed bright light treatment for rest-activity disruption in institutionalized patients with Alzheimer s disease. Int. J. Geriatr. Psychiatry 2005; 20: Dowling GA, Burr RL, van Someren EJW et al. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer s disease. J. Am. Geriatr. Soc. 2008; 56: Lyketsos CG, Veiel LL, Baker A, Steele C. A randomized, controlled trial of bright light therapy for agitated behaviors in dementia patients residing in long-term care. Int. J. Geriat. Psychiatry 1999; 14: Mishima K, Hishikawa Y, Okawa M. Randomized, dim light controlled, crossover test of morning bright light therapy for rest-activity rhythm disorders in patients with vascular dementia and dementia of Alzheimer s type. Chronobiol. Int. 1998; 15: Riemersma-van der Lek RF, Swaab DF, Twisk J, Hol EM, Hoogendijk WJG, van Someren EJW. Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: A randomized controlled trial. JAMA 2008; 299: O Connor DW, Griffith J, McSweeney K. Changes to psychotropic medications in the six months after admission to nursing homes in Melbourne, Australia. Int. Psychogeriatr. 2010; 22: O Connor DW, Ames D, Gardner B, King M. Psychosocial treatments of behavior symptoms in dementia: A systematic review of reports meeting quality standards. Int. Psychogeriatr. 2009; 21: Hoekert M, Riemersma RF, Swaab DF, Kaufer D, van Someren EJW. Comparison between informationobserved and actigraphic assessments of sleep-wake rhythm disturbances in demented residents of homes for the elderly. Am. J. Geriat. Psychiatry 2006; 14: Lockley SW, Skene DJ, Arendt J. Comparison between subjective and actigraphic measurement of sleep and sleep rhythms. J. Sleep Res. 1999; 8: Martin JL, Marler MR, Harker JO, Josephson KR, Alessi CA. A multicomponent nonpharmacological intervention improves activity rhythms among nursing home residents with disrupted sleep/wake patterns. J. Gerontol. 2007; 62A: Fetveit A, Skjerve A, Bjorvatn B. Bright light treatment improves sleep in institutionalised elderly an open trial. Int. J. Geriat. Psychiatry 2003; 18: Burns A, Allen H, Tomenson B, Duignan D, Byrne J. Bright light therapy for agitation in dementia: A randomized controlled trial. Int. Psychogeriatr. 2009; 4: Skjerve A, Holsten F, Aarsland D, Bjorvatn B, Nygaard HA, Johansen IM. Improvement in behavioral symptoms and advance of activity acrophase after short-term bright light treatment in severe dementia. Psychiatry Clin. Neurosci. 2004; 58: Yamadera H, Ito T, Suzuki H, Asayama K, Ito R, Endo S. Effects of bright light on cognitive and sleep-wake (circadian) rhythm disturbances in Alzheimer-type dementia. Psychiatry Clin. Neurosci. 2000; 54: Kobayashi R, Fukuda N, Kohsaka M et al. Effects of bright light at lunchtime on sleep of patients in a geriatric hospital. Psychiatry Clin. Neurosci. 2001; 55: Satlin A, Volicer L, Ross V, Herz L, Campbell S. Bright light treatment of behavioral and sleep disturbances in patients with Alzheimer s disease. Am. J. Psychiatry 1992; 149: Ancoli-Israel S, Martin JL, Kripke DF, Marler M, Klauber MR. Effect of light treatment on sleep and circadian rhythms in demented nursing home patients. J. Am. Geriatr. Soc. 2002; 50: Ito T, Yamadera H, Ito R, Suzuki H, Asayama K, Endo S. Effects of vitamin B12 on bright light on cognitive and sleep-wake rhythm in Alzheimer-type dementia. Psychiatry Clin. Neurosci. 2001; 55: Sloane PD. High-intensity environmental light in dementia: Effect on sleep and activity. J. Am. Geriatr. Soc. 2007; 55: Mishima K, Okawa M, Hishikawa Y, Hozumi S, Hori H, Takahashi K. Morning bright light therapy for sleep and behaviour disorders in elderly patients with dementia. Acta Psychiatr. Scand. 1994; 89: 1 7.

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