Inserm Liliane Bettencourt School

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1 Inserm Liliane Bettencourt School Scientific Directors: Jean-Claude Chottard 1, Philippe Ascher 2, 1 Paris Descartes University, Laboratory of Pharmacological and Toxicological Biochemistry and Chemistry, 2 Paris Descartes University, Laboratory of Cerebral Physiology, Administrative staff from the Inserm Liliane Bettencourt School: Cécile Parisy Inserm Liliane Bettencourt School Officer Barro Sow Assistant

2 Presentation of the Inserm Liliane Bettencourt School

3 General presentation The Inserm School was founded in It offers fast-track track research training for students from across France who have a strong interest in scientific research. Starting in the second year of study in medicine or pharmacy, it allows to obtain an early Master degree and later provides the possibility to obtain an MD- degree. In 2007, it was renamed the Inserm Liliane Bettencourt School thanks to funding from the Fondation Bettencourt Schueller for paying student fellowships.

4 Objective of the training offered by the Inserm Liliane Bettencourt School The program is designed to provide the opportunity to second year students of medicine and pharmacy to complement their clinical studies with a program preparing them for biological and medical research. It leads to a Master 2 degree, and subsequently to a Ph.D. The Master 2 degree must be prepared early in the curriculum, namely before the 4th year of the medical school, and after either the 3rd or 4th year of the pharmacy school. The Ph.D can be prepared either immediately after the Master 2, or later in the curriculum. The ultimate objective of this joint honors course is to enable future physicians and pharmacists to combine their clinical practice with research activity.

5 Diagram of the Inserm Lilian Bettencourt School Medicine track residency 15 Normal research course B1 B2 M1 M2 M3 M4 courses+ clinical training + M1 TU courses and clinical training internship M2-R research year internship part time part time Full time fellowship 13 residency 4 years M2 M3 M4 internship full-time internship 14 residency Path 1 Inserm School course B1 B2 M1 M2-R courses+ clinical training M1 TU 1 year + Ecole de 6 months Février research corses and clinical training + post master days full-time 3 years grant 2 years M2 M3 M4 courses and clinical training + annual scientific days (in September) fellowship internship 4 years 2 years 14 4 years residency 4 years Path 2 + post master days (in March) Annual scientific days: presentation of research findings by students (oral and poster presentations) preparation of while assuming clinical responsibilities

6 Normal research course Inserm Liliane Bettencourt course *HU: Year in a teaching hospital B1 (1st year of general healthcare studies) Diagram of the Inserm Lilian Bettencourt School Pharmacy track B1 (1st year of general 2 3 healthcare studies) Ecole de Février of the Inserm School Competitive exam for admission to internship M1 research TU + laboratory M1 TU HU * M2-R Competitive exam for admission to internship 6-month in a research laboratory M2-R HU * full-time (3 years) 5 HU * 6 M2-R Internship M2-R Research year 4 5 Research internship Internship Annual scientific days September + post-master scientific days March HU * HU * Internship End of internship Defense of DES** Medical biology internship & Hospital pharmacy internship, research option Pharmaceutical innovation and research internship Internship Competitive exam for admission to internship ** DES: Diploma of specialist health studies 1 Track: with internship 2 Track: without internship

7 How can you enroll in the Inserm Liliane Bettencourt School? Each French Faculty presents a list of students to be included in the School s initial selection. The selection committee asks Deans to examine applications upstream. Deans can hold interviews with students, to best assess their motivation and their ability to contribute to and profit from a course that requires a great deal of personal work. Application-based selection, open to students from across France (~ 50 applications selected) CV cover letter transcript of high school grades and specific honors transcript of grades and rank at the entrance examination of the 2 nd year of medical studies analysis of a recent scientific article The students selected then take part in the 2-week Ecole de février (see pages 10 and 11 for a more detailed description of this course)

8 The Ecole de Février 66 hours of classes 14 full days of training-motivation in residence at the Sèvres International Centre of Educational Studies (CIEP). Mathematical tools applied to biology and medicine 14 hours Physics 19 hours Chemistry 19 and a half hours Biology 14 hours 6 hours of analysis of scientific articles 24 hours of exchanges with teachers 6 conferences given by renowned researchers, capable of inciting enthusiasm in research

9 Ecole de Février program 2010 Physics 1. Molecular transport and diffusion 2. Molecular motors 3. Physics and functions of cellular materials 4. A few detection and decision-making mechanisms in cell biology Chemistry 1. Glycolysis and the respiratory chain. Chemical, physiological and pathological aspects 2. Chemical reactivity in a biological environment 3. Cytochromes P450 Biology Genomes and diseases: contribution of model systems 1. C.elegans 2. Drosophila 3. The zebrafish Mathematical tools applied to biology and medicine 1. Deterministic modeling of dynamic systems 2. Statistical modeling: the likelihood principle and applications in biology and medicine 3. Introduction to analysis of data from micro-array techniques

10 Entrance examination for the Inserm Liliane Bettencourt School The entrance examination is taken every year in June. It is based on two oral exams based on the analysis of documents 1 in biology (compulsory) 1 in either physics, chemistry or mathematical tools (the choice of field is made by the student). This exam is based on material taught in the Ecole de février completed by preparatory documents received 2 months in advance. Assessment focuses on the ability of applicants to use their knowledge in a research-oriented way. Following these exams, about twenty students are selected, the exact number depending on the level of applicants. These students will then be followed up by the whole teaching and administrative team which will help them find the laboratories where they will be initiated to research, and provide financial support.

11 The first 3 years lead to the obtention of a Master degree 1 st year - (in parallel with the 2 nd year of medical or pharmacy studies) Ecole de Février (14 days), Master 1 teaching unit (TU) and entrance examination for the Inserm School 2 nd year 2 nd year - (in parallel with the 3 rd year of medical or pharmacy studies) Master 1 TU, 6 months (or 2 x 3 months) full-time in a research laboratory (Inserm Aviesan). Presentation of the results obtained. 3 rd year - (interruption of the medical or pharmacy curriculum) Master 2 (required for continuing in the School s program).

12 Enrollment in a Master 2 requires 60 ECTS Medical students not belonging to the Inserm School usually only satisfy to these requirements after their sixth year of Medical School 18 ECTS - validation of Master 1 teaching units (equivalent to 2 former MSBM (Master of Biological and Medical Sciences) certificates) 12 ECTS - validation of 2 months of laboratory work completed in Master 1 (2 x 6 ECTS) 30 ECTS - validation of the sixth year of medical studies Medical students of the Inserm School can satisfy to these requirements after their third year of Medical School 6 ECTS - validation of the 2-week Ecole de Février course and passing of the June entrance examination 18 ECTS - validation of Master 1 teaching units in choice 36 ECTS - validation of the 6-month researchperiod in the 3rd year (6 x 6 ECTS) Universities are responsible for assessing the number of ECTS required for enrolling in a Master 2 (or 60 ECTS of Master 1). The proposal above, which corresponds to the procedure adopted by several universities, is given by way of example.

13 The post-master Scientific Sessions A 2- or 3-day meeting attended by 4th to 6th year medical students, doctoral students preparing a and interns. Devoted to a major medical theme chosen by the students, this meeting consists of conferences given by researchers in various disciplines and presentations by the School s students. It provides an opportunity for exchanges between speakers and students of the Inserm School.

14 The Scientific Sessions of September Objective: bring together all of the School s students and welcome newly selected applicants. The students present the research findings that they have obtained in the successive phases of the curriculum 6-month initial laboratory experience Preparation of a Master 2 Preparation of a Participation in research while an intern or extern Research performed during residency,etc. Presentations are made both orally in a plenary session and by posters.

15 Funding from the Fondation Bettencourt Schueller Fellowships for the selected students

16 Student fellowships (*2009/2010 figures) Funding from the Fondation Bettencourt Schueller Medicine track 30 months x * Research master Fellowship provided by the EDILB** M2 M3 M4 (subject to: post-master sem., conferences, workshops, lab. sem.) internship internship residency+ research Path 1 Medicine course and training in research B1 B2 M nd clinical cycle hospital fellowship 2 nd clinical cycle fellowship hospital salary hospital and university treatments Internship + research residency + research years Path 2 6 months x * M1 special agreement provided by the EDILB 10 months x * fellowships hospital salary 36 months x 1,684.93* gross hospital and university salaries years Agreement of each faculty 1, gross Work contract signed between the Inserm Regional Delegation and the student Independent of the EDILB Training in research: full-time in a laboratory part-time Research practice: while practising a medical activity ** Inserm Liliane Bettencourt School

17 Student fellowships (*2009/2010 figures) Funding from the Fondation Bettencourt Schueller Pharmacy track 20 months (10 months/year) x New agreement currently being written up 5 Internship 4 DES1 DES2 DES3 DES4 HU * Inserm School course 6 months x Special agreement provided by the EDILB B1 (1st year of general healthcare studies) Ecole de Février 2 3 M1 TU M2-R 6 monthlaboratory 10 months x full-time (3 years) fellowships 4 5 HU * 4 5 DES1 DES2 DES3 DES4 4 5 HU * HU * internship 24 months x 1, gross Procedures for implementing new annual work contracts to be signed between an Inserm regional delegation and the student taking the course Agreement of each university 1, gross Independent of the EDILB

18 2010/2011 calendar

19 calendar End of September through early November 2010: selection by Faculty Deans of applicants for the Inserm School 15 November 2010: deadline for submission of applications for the School, either by Deans or directly by students. Early December 2010: final selection of the 50 students who will take part in the 2011 Ecole de Février January 29 to February : Ecole de Février seminar March 11, 12 and 13, 2011: Post-master days Mid June 2011: entrance examination for the School s 2 nd year September 2011: Scientific sessions

20 Useful contacts

21 L équipe pédagogique de l Ecole de l Inserm Liliane Bettencourt Biochimie Jean Claude CHOTTARD Université Paris Descartes Laboratoire de Chimie et biochimie pharmacologiques et toxicologiques 45, Rue des Saints Pères Paris cedex Philippe ASCHER CNRS UMR 8118 Laboratoire de physiologie cérébrale UFR biomédicale 45, Rue des Saints Pères Paris cedex Olivia REINAUD Université Paris Descartes Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques 45, Rue des Saints Pères Paris cedex Eric FONTAINE Université Joseph Fourier Laboratoire de Bioénergétique Fondamentale et Appliquée Unité Inserm U Physique François AMBLARD CNRS - UMR 168 Institut Curie Laboratoire de Physico-Chimie 11, Rue Pierre et Marie Curie Paris

22 L équipe pédagogique de l Ecole de l Inserm Liliane Bettencourt (suite) Biologie Jean Louis BESSEREAU Inserm - Unité 789 Ecole Normale Supérieure Biologie Cellulaire de la Synapse 46, Rue d'ulm Paris Outils mathématiques Jean-Christophe THALABARD Hotel-Dieu Unité de Gynécologie Endocrinologie 1 Place Parvis Notre Dame Paris cedex Serge BIRMAN ESPCI Paris Tech, CNRS Laboratoire de neurobiologie 10 rue Vauquelin Paris cedex Khashayar PAKDAMAN Institut Jacques Monod Université Paris VII - Tour 43 2 Place Jussieu Paris cedex Philippe VERNIER CNRS - UPR 2197 Institut de Neurobiologie Alfred FESSARD 1 avenue de la Terrasse Gif sur Yvette cedex (secr)

23 The Inserm Liliane Bettencourt coordination team within Inserm Nicolas Pesnel Head of the Scientific Training and Support in Research Office +33 (0) (0) Cécile Parisy Inserm Liliane Bettencourt School Officer 101 rue de Tolbiac Paris cedex (0) (0) Barro Sow Inserm Liliane Bettencourt School Assistant +33 (0) (0)

24 The Association Médecine Pharmacie Sciences Founded by the School s students as a not-for-profit association, AMPS seeks to: foster professional links between students and researchers engaged in the various French programs aiming at combining an early training in science with a medical or pharmacy training give students the possibility to exchange and dialogue promote joint honors courses in Faculties of Medicine and Pharmacy in France structure a network of people driven by the same vision for French biomedical research.

25 Thank you for your attention!

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