Eric BUCHSER. born 12 th July 1949 Swiss national (Bätterkinden-BE)

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1 CURRICULUM VITAE Eric BUCHSER born 12 th July 1949 Swiss national (Bätterkinden-BE) Professionnal address Private address EHC-Hôpital de Morges Crêt-Mouton Morges 1603 Grandvaux Switzerland October 2004 October 2002 October 1991 October 1987 September 1983 May 1983 June 1977 POSTGRADUATE TRAINING Professeur titulaire in Anaesthesiology Faculty of Biology & Medicine, University of Lausanne Switzerland Privat-Docent & Maître d'enseignement et de recherche Faculty of Biology & Medicine, University of Lausanne Switzerland Sub-Speciality in Intensive Care Agrégé of faculty Faculty of Medicine, University of Lausanne - Switzerland Specialist in Anaesthesia Doctorate in Medicine Federal Diploma of Medicine University Hospital CHUV, Lausanne Pain clinic, Clinical Fellow, University Hospital, University of Washington, Seattle. Anaesthesiology, Clinical Fellow, Anaesthesia Department, McGill University, Montreal, Canada CURRENT POSITION Head of the Anaesthesia and Pain Management Services Neuromodulation Centre Hôpital de Morges, Switzerland Consultant in Anaesthesia, University Hospital, CHUV, Lausanne, Switzerland

2 PUBLICATIONS IN PEER REVIEWED JOURNALS (TOTAL 66) Publications in the area of pain management & neuromodulation, last 5 years (21) 45. Neurostimulation technology for the treatment of chronic pain A focus on spinal cord stimulation. Foletti A, Durrer A, Buchser E. Expert Rev Med. Devices 4(2): (2007) 46. Avoiding Complications from Spinal Cord Stimulation: Practical Recommendations from an International Panel of Experts. Kumar K, Buchser B, Linderoth B, Meglio M, Van Buyten B. Neuromodulation 10(1): (2007) 47. Guidelines for anaesthesiologist specialist training in pain medicine. Cunningham AJ, Knape JTA, Adriaensen H, Blunnie WP, Buchser E, Goldik Z, Ilias W, Paver-Erzen V. European Journal of Anaesthesiology 24: (2007) 48. Spinal cord stimulation versus conventional medical management for neuropathic pain: A multicentre randomised controlled trial in patients with failed back surgery syndrome. Kumar K, Taylor R, Jacques L, Eldabe S, Meglio M, Molet J, Thomson S, O Callaghan J, Eisenberg E, Milbouw G, Buchser E, Fortini G, Richardson J, North R. Pain 132: (2007) 49. Polyanalgesic consensus conference 2007: Recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Deer, T. R., Krames, E.S., Hassenbusch, S. J., Burton, A., Caraway, D., Dupen, S., Eisenach, J., Erdek, M., Grigsby, E., Kim, P., Levy, R., McDowell, G., Mekhail, N., Pachal, S., Prager, J., Rauck, R. L., Saulino, M., Sitzman, T., Staats, P., Stanton-Hicks, M., Stearns, L., Willis, K.D., Witt, W., Follett, K. A., Huntoon, M., Liem, L., Rathmell, J., Wallace, M., Buchser, E., Cousins, M., Ver Donck, A. Neuromodulation 10(4) : (2007) 50. Sacral Neuromodulation for Refractory Lower Urinary Tract Dysfunction: Results of a Nationwide Registry in Switzerland. Kessler Th, Buchser E, Meyer S, Engeler D, Al-Khodairy A, Bersch U, Iselin C, Roche B, Schmid D, Schurch B, Zrehen S, Burkhard F. European Urology 51: (2007) 51. Neuromodulation pour le traitement de la douleur chronique. Rutschmann B, Mustaki JP, Buchser E. Forum Médical Suisse 16: (2008) 52. Management of intrathecal catheter-tip inflammatory masses: an updated 2007 consensus statement from an expert panel. Deer T, Krames ES, Hassenbusch S, Burton A, Caraway D, Dupen S, Eisenach J, Erdek M, Grigsby E, Kim Ph, Levy R, MD, McDowell G, Mekhail N, Panchal S, Prager J, Rauck R, Saulino M, Sitzman T, Staats P, Stanton-Hicks M, Stearns L, Willis KD, Witt W, Follett K, Huntoon M, Liem L, Rathmell J, Wallace M, Buchser E, Cousins M, Ver Donck A. Neuromodulation 11(2):77-91 (2008). 53. Future directions for intrathecal pain management: a review and update from the interdisciplinary polyanalgesic consensus conference Deer T, Krames ES, Hassenbusch S, Burton A, Caraway D, Dupen S, Eisenach J, Erdek M, Grigsby E, Kim Ph, Levy R, MD, McDowell G, Mekhail N, Panchal S, Prager J, Rauck R, Saulino M, Sitzman T, Staats P, Stanton-Hicks M, Stearns L, Willis KD, Witt W, Follett K, Huntoon M, Liem L, Rathmell J, Wallace M, Buchser E, Cousins M, Ver Donck A. Neuromodulation 11(2):92-97 (2008). 54. Nonlinear analysis of human physical activity patterns in health and disease. Paraschiv- Ionescu, A, Buchser, E, Rutschmann, B, Aminian, K. Physical Review E 77(2) (2008).

3 55. Spinal cord stimulation versus conventional medical management for failed back surgery syndrome: long-term results from the PROCESS study. Eldabe S, Taylor R.S, Thomson S, Buchser E, Journal of Neurology vol. 255, suppl 2, June (2008). 56. Patient-controlled analgesia in chronic pain patients: experience with a new device designed to be used with implanted programmable pumps. Ilias W, Le Polain B, Buchser E, Demartini L. Pain Practice 8(3) : (2008). 57. Quality of life, resource consumption and costs of spinal cord stimulation versus conventional medical management in neuropathic pain patients with failed back surgery syndrome (PROCESS trial). Andrea Manca, Krishna Kumar, Rod S. Taylor, Line Jacques, Sam Eldabe, Mario Meglio, Joan Molet, Simon Thomson, Jim O Callaghan, Elon Eisenberg, Germain Milbouw, Eric Buchser, Gianpaolo Fortini, Jonathan Richardson, Rebecca J. Taylor, Ron Goeree, Mark J. Sculpher. European Journal of Pain 12: (2008). 58. Spinal cord stimulation in the treatment of refractory angina : systematic review and meta-analysis of randomised controlled trials. Taylor R.S, DeVries J, Buchser E, DeJongste M. JL. BMC Cardiovascular Disorder 9:13 (2009). 59. Spinal Cord Stimulation for the Treatment of Chronic Pain in Patients with Lumbar Spinal Stenosis. Costantini A, Buchser E, Van Buyten JP. Neuromodulation 13: (2010) 60. An Analysis of the Components of Pain, Function, and Health-Related Quality of Life in Patients with Failed Back Surgery Syndrome Treated with Spinal Cord Stimulation or Conventional Medical Management. Eldabe S, Kumar K, Buchser E, Taylor RS. Neuromodulation 13: (2010) 61. Relationship between Health-Related Quality of Life, Pain, and Functional Disability in Neuropathic Pain Patients with Failed Back Surgery Syndrome. Manca A, Eldabe S, Buchser E, Kumar K, Taylor RS. Value in Health 13: (2010) 62. The lack of efficacy of different infusion rates of intrathecal baclofen in complex regional pain syndrome: a randomized, double-blind, crossover study. van der Plas AA, Marinus J, Eldabe S, Buchser E, van Hilten JJ. Pain Med 12: (2011) 63. Effects of Flow Rate Modifications on Reported Analgesia and Quality of Life in Chronic Pain Patients Treated with Continuous Intrathecal Drug Therapy. Perruchoud C, Eldabe S, Durrer A, Bovy M, Brookes M, Madzinga G, Garner F, Batterham AM, Menoud C, Jacobs M, Gulve A, Buchser E. Pain Med 12: (2011) 64. The lack of efficacy of different infusion rates of intrathecal baclofen in complex regional pain syndrome: a randomized, double-blind, crossover study. van der Plas AA, Marinus J, Eldabe S, Buchser E, van Hilten JJ:. Pain Med 12: (2011) 65. Severe hypertension following accidental clonidine overdose during the refilling of an implanted intrathecal drug delivery system. Perruchoud C, Bovy M, Durrer A, Rosato M, Rutschmann B, Mustaki J P. Buchser E. Neuromodulation 2012;15(1):31-34 (2012) 66. Barcoding human physical activity to assess chronic pain conditions. Paraschiv-Ionescu A, Perruchoud C, Buchser, E, Aminian, K. PLoS One 7(2):e32239 (2012) PUBLICATIONS IN NON-PEER REVIEWED JOURNALS (11)

4 CHAPTERS IN BOOKS AND MONOGRAPHIES (7) 1. Douleurs intraitables ou douleurs rebelles? Collection Amaryllis - les Annales de soins palliatifs. Buchser E, Chédel D. Douleur et antalgie No 2: (1993) 2. Spinal cord stimulation of chronic back and leg pain / failed back surgery syndrome & complex regional pain syndrome: a systematic review of the clinical effectiveness and cost effectiveness literature. Taylor R, Van Buyten J-P, Buchser E. Edgbaston, Birmingham (2002) 3. The future of spinal cord stimulation Buchser E, Thomson S. In Electrical Stimulation and the Relief of Pain, Brian Simpson ed. Pain Research and Clinical Management, Vol 15, Elsevier Amsterdam, Boston, Heidelberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo, Vol 15, ISBN Series: , ISBN Vol. 15: (2003) 4. Updated consensus on intrathecal drug delivery for the treatment of intractable pain. Buchser E. In Highlights in Regional Anaesthesia and Pain Therapy. XIII (2004) Narinder Rawal and Slobodan Gligorijevic Eds, ISBN: (2004) 5. Objective Measurement of Physical Activity in Patients with Chronic Lower Limb Pain Treated with Spinal Cord Stimulation. Buchser E, Paraschiv-Ionescu A, Durrer A, Aminian K. In Proceedings of the Medtronic Forum for Neuroscience and Neuro- Technology Eds. Van Hilten B, Nuttin B, Progress in Neuroscience and Therapeutic Neurostimulation, Vol 1, Springer, ISBN (2006) 6. Manuel pratique d anesthésie. Eds. Albrecht E, Haberer JP, Buchser E. Elsevier- Masson S.A.S,ISBN (2006) 7. Manuel pratique d anesthésie Eds. Albrecht E, Haberer JP, Buchser E. Moret V. Elsevier-Masson S.A., ISBN (2009) ABSTRACTS AND POSTERS (MORE THAN 100) Pain management & neuromodulation, last 3 years (13) 1. Pain in failed back surgery syndrome patients following spinal cord stimulation and conventional medical management. Buchser E, Eldabe S, Kumar K, Taylor RS. 9 th World Congress of the International Neuromodulation Society, Firenze, Italy, 12-14/06/ Function and quality of life in failed back surgery syndrome patients following spinal cord stimulation and conventional medical management. Buchser E, Eldabe S, Kumar K, Taylor RS. 9 th World Congress of the International Neuromodulation Society, Firenze, Italy, 12-14/06/ Accidental clonidine overdose at the refilling of Synchromed ll pumps. Perruchoud Ch, Durrer A, Buchser E, Rutschmann B, Mustaki J-P, Rosato M-L. 13 th Annual Meeting of the North American Neuromodulation Society, Las Vegas, USA, 3-6/12/2009

5 4. In-Depth Analysis of the Improvement in Pain, Function and Quality of Life in Patients with Failed Back Surgery Syndrome after Spinal Cord Stimulation and Conventional Medical Management. Kumar K, Eldabe S, Buchser E, Taylor R. Neurosurgery 2009; 65: The Relationship between Quality of Life, Disability and Pain in Patients with Failed Back Surgery Syndrome. Manca A, Eldabe S, Buchser E, Kumar K, Taylor R: Value in Health 2009; 12: A136-A Pain in failed back surgery syndrome patients following spinal cord stimulation and conventional medical management. Buchser E, Eldabe S, Kumar K, Taylor RS. 9 th World Congress of the International Neuromodulation Society, Firenze, Italy, 12-14/06/ Mise en place d'un registre des accidents de la voie publique dans une grande agglomération du Sud-Est Asiatique. Guyot E, Marques-Vidal P, Hanh T, Khai T, Durrer A, Perruchoud C, Buchser E, Yersin B. 4 ème Congrès de la Société Française de Médecine d Urgence, Paris, France, 02-04/06/ Intrathecal administration of Ziconotide: does single-shot injection predict efficacy? Perruchoud Ch, Bovy M, Smit A, Rutschmann B, Durrer A, Buchser E. Swiss Society of Anaesthesiology Congress, Lausanne, 4-6/11/ Intrathecal drug delivery systems for cancer pain. Perruchoud Ch, Bovy M, Durrer A, Rutschmann B, Buchser E. Swiss Society of Anaesthesiology Congress, Lausanne, 4-6/11/ Subcutaneous field stimulation for refractory low back pain. Rutschmann B, Perruchoud C, Durrer A, Le Berre J, Depierraz B, Koeppel C, Buchser E. 12 th World Congress on Pain, Montréal, Canada, 29/8-02/09/ Ziconotide trial with single-shot intrathecal injection. Mustaki JP, Perruchoud C, Smit A, Rutschmann B, Durrer A, Lepage C, Buchser E. 13 th World Congress on Pain, Montréal, Canada, 29/8-02/09/ Treatment of visceral phantom pain with SCS: a case report. Bovy M, Perruchoud C, Durrer A, Rutschmann B, Buchser E. International Neuromodulation Society Meeting, London, UK, 21-26/05/ Subcutaneous field stimulation for low-back pain: a 96 months follow-up. Perruchoud C, Durrer A, Bovy M, Rutschmann B, Koeppel C, Kirchhofer E, Leberre J, Buchser E. International Neuromodulation Society Meeting, London, UK, 21-26/05/2011 REVIEWER 1. Current Anaesthesia & Critical Medicine Editorial Advisory Board ( ) 2. European Journal of Anaesthesia 3. European Journal of Cardio-thoracic Surgery 4. Neuromodulation 5. Pain Medicine 6. Pain 7.Clinical Journal of Pain 8. Pain Practice

6 INVITED SPEAKER (MORE THAN 100) GRANTS (PEER REVIEWED) Crédit de développement du Service de la Santé Publique pour le développement d un service d antalgie, dans le cadre d un contrat de performance. E. Buchser, B. Burnand, F. Paccaud Prise en charge antalgique des patients chirurgicaux: une étude comparative des effets sur la douleur, les complications et la durée de séjour Subside du Fonds National Suisse de la Recherche Scientifique No E. Buchser, B. Burnand, Ph. Leuenberger, F. Paccaud. Postoperative pain management: efficacy, complications and effects on arterial oxygen saturation and spontaneous physical activity Subside du Fonds National Suisse de la Recherche Scientifique No E. Buchser, B. Burnand, D. Chédel, F. Paccaud, P. Guex Hypnosis and self-hypnosis, administered and taught by nurses, for the reduction of chronic pain: a controlled clinical trial Cythotherapeutics P. Aebischer, N. de Tribolet, E. Buchser et coll. Traitement de la douleur par transplantation intrathécale de cellules chromaffines bovines. En collaboration avec la Division de Recherche Chirurgicale et le Service de Neurochirurgie du CHUV Fonds de Performance du Service de la Santé Publique du Canton de Vaud. Evaluation des facteurs médicaux et socio-économiques entravant la diminution de la durée de séjour hospitalier après hystérectomie, chirurgie de résection colique et arthroplastie de la hanche. En collaboration avec le Dr B. Burnand, IUMSP Subside du Fonds National Suisse de la Recherche Scientifique No /9 Intrathecal implantation of encapsulated bovine adrenal chromaffin cells for the treatment of cancer pain: a clinical randomised double blind phase II study. En collaboration avec la Division de Recherche Chirurgicale et l Institut Universitaire de Médecine Sociale et Préventive de Lausanne Subside CHUV-EPFL-Medtronic Effet clinique de la stimulation médullaire lors d arthériopathie obstructive périphérique. En collaboration avec le laboratoire de métrologie de l EPFL, de la division d Angiologie du CHUV et de Medtronic Medtronic Numerical, experimental and clinical investigation of mixing optimization of local anaesthetics with cerebrospinal fluid in the subarachnoid space. En collaboration avec le laboratoire de mécanique des fluides de l EPFL Federal Commission for technology and innovation Grant (CTI) No MTS-LS Developement of a portable monitoring and expert system for the long-time recording and detailed analysis of the spontaneous physical activity (postures and gait) in real life environment. En collaboration avec le laboratoire de métrologie de l EPFL (K. Aminian) et Medtronic-Europe Federal Commission for technology and innovation Grant (CTI) No

7 6569.2MTS-LS Development of an expert system (algorithm) to predict the effect of intrathecal drug administration. En collaboration avec le laboratoire de mécanique des fluides de l EPFL (Prof P. Monkewitz) et Medtronic-Europe. TEACHING 1. General Anaesthesia 2. Examiner at the Diploma of the European Academy for Anaesthesiology 3. European Academy Examination board (1989) 4. Chairman of the European Diploma of Anaesthesia and Intensive care examination Part II 5. Examiner at the Swiss Examination of Anaesthesiology (since 1989) AFFILIATIONS - International Association for the Study of Pain, Swiss Society for the Study of Pain (1993) - Swiss Society of Anaesthesia and Reanimation (1985) Board member ( )) - Swiss Society of Intensive Care Medicine (1986) - European Society of Intensive Care Medicine (1989) - European Academy of Anaesthesia and Intensive care Medicine (1991) - Swiss Society of Palliative Care Medicine (Founding Member, 1988) - International Society for Neuromodulation (1995) - Swiss Neuromodulation Society (2011) Swiss Society for Interventional pain management (2009) Morges the 9 th of April 2012

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