confidence in BioHorizons

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2 confidence in BioHorizons BioHorizons is dedicated to developing evidence-based and scientifically proven products. From the launch of the External implant system (Maestro) in 1997, to the Laser-Lok 3.0 implant in 2010, dental professionals as well as patients have confidence in our comprehensive portfolio of dental implants and biologics products. Our commitment to science, innovation and service has aided us in becoming one of the fastest growing companies in the dental industry. BioHorizons has helped restore smiles in 85 markets throughout Asia, North America, South America, Africa, Australia and Europe. SCIENCE BioHorizons uses science and innovation to create unique products with proven surgical and esthetic results. INNOVATION Our advanced implant technologies, biologic products and computer guided surgery software have made BioHorizons a leading dental implant company. SERVICE BioHorizons understands the importance of providing excellent service. Our global network of professional representatives and our highly-trained customer care support team are well equipped to meet the needs of patients and clinicians Laser-Lok surface treatment optimization begins BioHorizons founded External implant (Maestro) launches international distribution begins introduce AlloDerm RTM & Grafton DBM

3 One-piece 3.0 implant Internal Implant & MinerOss Tapered Internal implant & Laser-Lok 2008 surgical treatment planning software 2010 Laser-Lok 3.0 two-piece implant today distribution in 85 markets

4 it s not just about technology treatment planning Virtual Implant Placement (VIP) treatment planning software gives dental implant professionals a user-friendly way to determine the optimal dental implant position prior to placement and has been successfully used in thousands of clinical procedures. instruments & motors Whether it is our microsurgical instruments designed for less invasive procedures, or our surgical instruments developed for bone augmentation applications, our broad line of instruments and motors will meet your needs. biologics Recognized as a global leader for tissue regeneration solutions that include: AlloDerm RTM AlloDerm GBR Grafton DBM MinerOss LADDEC Mem-Lok Our Biologic products are scientifically proven for a wide range of soft and hard tissue applications.

5 it s about innovative solutions that work dental implants BioHorizons implants are clinically proven through some of the most thorough and in-depth research in the industry. We offer 4 comprehensive implant lines and 3 small diameter systems, covering virtually every surgical and prosthetic indication or clinician preference. Our dental implants have a 99.2% average implant success rate 1-10 and also come with a lifetime warranty giving you peace of mind. prosthetics Our broad range of prosthetic cover a wide range of indications and patient conditions and feature some of the tightest machine tolerances in the dental industry. Our unique conical connection creates a biologic seal eliminating the microgap seen with other systems. Through advanced Spiralock technology, abutment screws remain tight over time.

6 Laser-Lok microchannels Laser-Lok dental implant at 8 years post-restoration showing superior crestal bone & tissue maintenance. Exclusively from BioHorizons, Laser-Lok is the only surface treatment shown to attract a true, physical connective tissue attachment (unlike Sharpey fibers) 11. Laser-Lok is a series of precision-engineered cell-sized channels laser-machined onto the surface of dental implants and abutments. Exemplifying our dedication to evidence-based research and development, it is unlike any other dental abutment or implant surface treatment Case courtesy of Cary A. Shapoff, DDS (Surgical); Jeffrey A. Babushkin, DDS (Restorative) on the market. esthetics enhanced Only surface treatment shown to attract a true, physical connective tissue attachment (unlike Sharpey fibers) 11 Multi-center prospective study showing only 0.59mm of bone loss compared to 1.94mm for traditional implants 12 Overdenture study showing only 0.42mm of bone loss compared to 1.13mm for NobelReplace Select 13 Over 20 years of in vitro, animal and human studies at leading universities 14 Long-term case study showing superior bone & tissue maintenance 15 Bone Loss (mm) 0.00 The Laser-Lok Advantage 12 Laser-Lok Control mm Laser-Lok advantage mm Months Post-Op NobelReplace is a trademark of Nobel Biocare.

7 by technology SEM (5,000X) of Laser-Lok showing micro & nanostructure of the 12 micron microchannels. colorized SEM (2,500X) of a dental implant harvested at 6 months post-op showing interdigitated connective tissue.

8 which dental implants are right for you? Tapered Internal Internal Single-stage External Laser-Lok 3.0 Overdenture 3.0 One-piece 3.0 body-type tapered parallel-wall connection internal hex external hex placement bone level tissue level surface treatment Laser-Lok body RBT body / Laser-Lok collar RBT body HA body delivery mount-free 3inOne abutment No machined collar. Comprehensive Implant Systems Small Diameter Solutions

9 tapered internal Tapered Internal dental implants provide excellent primary stability, maximum bone maintenance and soft tissue attachment for optimal esthetics. The Tapered Internal implant achieves these benefits from its anatomically tapered dental implant body, aggressive buttress threads and advanced Laser-Lok surface technology. The deep 1.5mm internal hex connection with a lead-in tapered bevel create a rigid connection and a stable biologic seal. Case courtesy of Craig Misch, DDS FEATURES Anatomically tapered body and proprietary buttress threads for compressive bone loading and excellent primary stability. body-type connection placement surface treatment delivery options platform diameters body diameters lengths tapered internal hex bone level Laser-Lok body Laser-Lok collar with RBT body mount-free 3inOne abutment 3.5mm 4.5mm 5.7mm 3.8mm 4.6mm 5.8mm 7.5mm 9mm 10.5mm 12mm 15mm

10 internal Internal dental implants provide maximum surface area through the use of its parallel-walled body and square thread design. It also is available with Laser-Lok microchannels to create a physical, connective tissue attachment (unlike Sharpey fibers) and long-term crestal bone maintenance. 11 Case images courtesy of Dr. Jin Kim FEATURES Proprietary biomechanical thread design maximizes implant surface area. 16 Most widely used connection in implant dentistry. body-type connection placement surface treatment delivery options platform diameters body diameters lengths parallel-wall internal hex bone level Laser-Lok collar with RBT body RBT body HA body mount-free 3inOne abutment 3.5mm 4.5mm 5.7mm 3.5mm 4.0mm 5.0mm 6.0mm 9mm 10.5mm 12mm 15mm

11 single-stage Unlike similar soft-tissue level implant designs, the Single-stage dental implant features the BioHorizons power thread with maximum surface area to support the high occlusal forces often seen in the posterior. This gives dentists confidence that their placements will remain secure long-term even with limited ridge height and in softer bone. FEATURES Power thread provides up to 154% greater surface area. 16 Two body diameters for each platform. body-type connection placement surface treatment delivery platform diameters body diameters lengths parallel-wall internal hex tissue level Laser-Lok collar with RBT body RBT body mount-free 3.5mm 4.5mm 5.7mm 3.5mm 4.0mm 5.0mm 6.0mm 7mm 9mm 10.5mm 12mm 15mm

12 external The External dental implant, originally known as the Maestro, has performed successfully in every published study since its launch in The external implant has survival rates from 98.5% to 100% in studies of up to 1,400 implants and a follow up of 10 years It has also been shown to achieve bone-to-implant contact levels of 80.6%. 17 Clinicians confidently rely on the External implant to achieve consistent, reproducible results necessary to build a successful implantology practice. Reverse torque removal values Ncm Ncm V-Thread Square Thread strength in square threadform Our square thread design transmits 10 times less destructive shear than conventional v-threads. 16 FEATURES body-type connection placement surface treatment delivery body/platform diameters lengths parallel-wall external hex bone level RBT body HA body 3inOne abutment 3.5mm 4.0mm 5.0mm 6.0mm 7mm 9mm 10.5mm 12mm 15mm Over 80% bone contact at one year. Concentric and interstitial lamellae are apparent. 19

13 short implants solutions for limited vertical spaces BioHorizons short implants feature the Laser-Lok surface technology across the entire implant body with no machined collar for faster osseointegration and higher bone to implant contact. 20 They are ideal for anatomically challenging conditions. Standard 12mm implant Short implant FEATURES body-type connection placement surface treatment delivery platform diameters body diameters lengths tapered* internal hex bone level Laser-Lok body mount-free 4.5mm 5.7mm 4.6mm 5.8mm 7.5mm 9mm *additional short implants available soon Not available in all countries Extreme magnification showing organized Laser-Lok surface treatment on the implant threads.

14 laser-lok 3.0 Laser-Lok 3.0 dental implants are designed specifically for limited spaces in the esthetic zone and are placed easily with 2.0 and 2.5mm drills. The two-piece 3mm design offers restorative flexibility in narrow spaces. The 3mm threadform shown to be effective when immediately loaded. 21 Implant design is more than 20% stronger than competitor implant. 22 Max Load (lbs) Laser-Lok 3.0 Competitor 3.0 implant Fatigue cycles With a broad array of prosthetic options available, the Laser-Lok 3.0 is the perfect choice for high profile cases. FEATURES body-type connection placement surface treatment delivery body/platform diameters lengths parallel wall internal hex bone level Laser-Lok collar with RBT body mount-free 3.0mm 10.5mm 12mm 15mm

15 one-piece 3.0 overdenture 3.0 The One-piece 3.0, originally known as Maximus, is indicated for long-term replacement of missing maxillary laterals and mandibular incisors. It has an overall success rate of 96.7% 4 and was the first implant of its kind when it was launched in Despite its size, the One-piece 3.0 has been shown to be stronger in load-to-failure than other implants less than 4mm. 23 The One-piece 3.0 achieves solid results with only 0.53mm bone loss at 12 months. 24 Overdenture dental implants offer affordable denture stabilization for many candidates with ridges too narrow for placement of wider, two-piece systems. The biomechanical square thread design is proven to have high stability and increase bone-to-implant contact. 18 Our one-piece design provides maximum strength and restorative simplicity. Minimal instrumentation is needed for implant placement FEATURES FEATURES body-type connection surface treatment delivery abutment height body diameter body lengths parallel wall one-piece RBT body HA body mount-free 8.0mm 3.0mm 12mm 15mm 18mm body-type connection surface treatment delivery collar height body diameter body lengths parallel wall one-piece RBT body mount-free 2.0mm 4.0mm 3.0mm 12mm 15mm 18mm

16 prosthetics BioHorizons offers a broad array of abutments for a wide range of indications and patient conditions including the versatile 3inOne abutment and the convenient Simple Solutions restorative system. Our conical abutment-implant connection and tight machining tolerances create a wedging effect that produces a biologic seal. Abutment screw loosening is avoided by the Spiralock thread design, the same design used in the orthopedic and aerospace industries. 3inOne abutment The 3inOne abutment is offered separately or can come pre-mounted on Tapered Internal, Internal and External implants. It is the most versatile abutment on the market because of its three useful functions: Conical connection creates a biologic seal. implant mount for delivering the implant to the surgical site closed tray transfer coping (with a ball-top screw) esthetic gold-hued final abutment Spiralock threads prevent screw loosening.

17 simple solutions with laser-lok With the success of BioHorizons Laser-Lok technology on implants, BioHorizons breaks new ground by applying this innovative technology to abutments. The Simple Solutions abutment with Laser-Lok is designed to be seated at the time of implant placement and remain in place through final restoration. 25,26 This establishes and maintains the connective tissue attachment (unlike Sharpey fibers) while eliminating the second stage surgery. Epithelial downgrowth Standard abutment at 3 months Laser-Lok abutment at 3 months Connective tissue Bone loss 200µm New bone Connective tissue attachment Comparative histology showing the Laser-Lok abutment advantage versus conventional abutments. 27

18 biological-based solutions for clinical excellence AlloDerm Case courtesy of Dr. Edward P. Allen, Dallas, Texas (top) AlloDerm GBR Case courtesy of Dr. Lewis C. Cummings, Kingwood, Texas (center) MinerOss Case courtesy of Dr. Bach Le, Whittier, California (bottom)

19 AlloDerm AlloDerm GBR Since its introduction to dentistry in 1994, AlloDerm Regenerative Tissue Matrix (RTM) has been a widely accepted acellular dermal matrix (ADM) for soft tissue applications. AlloDerm RTM supports tissue regeneration by allowing rapid revascularization, white cell migration and cell population ultimately being transformed into host tissue for a strong, natural repair. AlloDerm GBR is manufactured utilizing the same proprietary process used for AlloDerm, however AlloDerm GBR is used as an effective barrier membrane. Compared to bioabsorbable membranes, AlloDerm GBR is remodeled into the patient s own tissue. 31 Most published ADM in implant dentistry Shown to reduce post operative complications 28 Randomized clinical trials indicate no statistical difference to connective tissue for recession coverage 29 Benefits soft tissue quality and esthetics while serving as a barrier membrane 31 Less technique sensitive due to its ability to be exposed during healing 32 Proven alternative to bioabsorbable membranes 33 APPLICATIONS INCLUDE 30 Root coverage Gingival augmentation Soft tissue ridge augmentation Soft tissue augmentation around implants APPLICATIONS INCLUDE 30 Graft protection and containment Flap extender to achieve primary closure

20 clinically proven bone graft substitute Grafton DBM Clinicians desire predictability and flexibility when using a bone graft substitute. The proven clinical success of Grafton DBM in multiple forms gives clinicians the ideal bone graft for the specific application. Cleared for a broader range of indications than any other DBM or commercially available BMP, 34 Grafton DBM gives you the ability to regenerate bone height and width. 35 Forms include Matrix Plugs, Putty in a Syringe or Jar, Flex, and Paste in a Syringe Validated for osteoinduction in an in vivo model 36 Superior osteoconduction through Bone Fiber Technology Grafton DBM Matrix Plugs and Putty incorporate bone fibers rather than particles. The fibers create a physical network of pathways for bone forming cells to migrate. APPLICATIONS INCLUDE 30 Extraction socket grafting Ridge and sinus augmentation Bone augmentation around implants Bony defects Composite grafting with MinerOss Periodontal regeneration

21 MinerOss ideal composition for successful bone regeneration Developed to address a wide range of applications, MinerOss is a mixture of allograft mineralized cortical and cancellous chips. The cancellous and cortical blend forms an osteoconductive scaffold providing volume enhancement and effective site development for successful dental implant placement. Facilitates bone formation through retention of natural osteoconductive properties Provides advantage of having the combination of cortical and cancellous chips in one vial Excellent mechanical stability for strength and structure during the bone remodeling process APPLICATIONS INCLUDE 30 Ridge and sinus augmentation Socket grafting Periodontal defects Grafting for implant placement Composite grafting with Grafton DBM Cortical chips provide structure for space maintenance. Cancellous chips have increased surface area for bone forming cells to deposit.

22 400 Suture pull-out strength Mem-Lok 350 ± Grams 200 easy handling, long lasting Engineered from highly purified type I collagen fibers to provide an increased resorption period and ensure optimal bone regeneration, clinicians can be confident that Mem-Lok will serve as an effective barrier membrane for bone regeneration ±10 Predictable resorption period of weeks 38 Macromolecular pore size permeability that permits the exchange of essential nutrients during healing Adapts easily to various bony defects 0 BioMend Mem-Lok Dense fibers allow for increased mechanical strength. 37 APPLICATIONS INCLUDE 30 Extraction sockets Sinus augmentation sinus window Ridge preservation Bone augmentation around implants Bony defects Peri-implant bone defect around implants

23 instruments & motors W&H Motors W&H motors and handpieces are distinguished by their precision craftsmanship and reliability. The ImplantMed and ElcoMed are widely renowned for cutting performance and ease of use in maxillofacial surgery, implantology and microsurgery. All handpieces offer maximum efficiency and constant torque when and where users need it. Esthetic post operative outcomes require innovative surgical instrumentation. BioHorizons complete portfolio of instrumentation and motors will meet all your clinical needs. AutoTac AutoTac is the only membrane fixation system available that allows you to effectively secure membranes with the push of a button. The proprietary delivery handle drives titanium alloy tacks that stabilize the membrane during the healing process. Hu-Friedy Hu-Friedy s unsurpassed reputation and guarantee behind every product make them the industry leader for instrumentation. In addition to Hu-Friedy s complete range of surgical instruments, surgical kits have been designed to address specific clinical procedures. Bone Screw Kit Developed to address onlay bone grafting procedures, the compact kit of precision-machined titanium alloy components is versatile and effective for stabilizing block grafts.

24 Virtual Implant Placement computer guided surgery VIP was exclusively developed for clinicians who prefer an innovative and user-friendly treatment planning solution to help deliver a predictable surgical outcome. The integration of digital treatment planning for diagnosis and our Compu-Guide surgical templates for guided surgery gives you the confidence for a safe and effective procedure. VIP BENEFITS Interactive 2D and 3D treatment planning Open implant platform designed for cross implant compatibility DICOM converter for instant file conversion

25 communication Clinicians can clearly communicate the goal of the implant treatment to the patient and the implant treatment team. implant treatment A fully integrated virtual treatment planning solution that increases case predictability and enhances post operative outcome. diagnosis 2D and 3D visualization in VIP provides reliable analysis and diagnosis of the patient s anatomy. pilot compu-guide Surgical templates are manufactured using advanced CNC technology where the submitted VIP plan data defines implant location, depth, and angulation.

26 why choose BioHorizons? value BioHorizons provides the highest quality products and the most value. For example, every BioHorizons bone-level implant is available with a gold-hued, esthetic final abutment, an abutment screw, and a cover cap for submerged protocol. design Dental professionals want tools and components that work and fit well. BioHorizons parts feature tight machine tolerances that provide a great surgical & restorative experience. materials All BioHorizons implants are made of titanium alloy which is 1.5 to 3.5 times stronger than pure titanium implants from other companies. This strength difference can affect the long term success of an implant and is critical for small diameter implants. leadership BioHorizons has a rich history of working with key thought leaders within the periodontal, oral surgery, prosthodontic and general practitioner communities to enhance our designs and adopt the latest techniques. simplicity All BioHorizons implants and prosthetics are color-coded for easy identification. Restorative dentists can quickly identify implant type and diameter while the patient is in the chair. convenience Our interactive website gives visitors a valuable online experience with useful information. The new graphics-based, online catalog enables visitors to view detailed product specs and US customers to review account history, place orders 24/7, and track shipments. confidence All BioHorizons implants and prosthetic components come with a lifetime warranty. education Continuing education is crucial to the rapidly changing field of implant dentistry. With our support of over 700 surgical and restorative educational events each year, BioHorizons is committed to advancing technologies and the quality of care. service BioHorizons is dedicated to effectively meeting your needs with our team of professionallytrained customer care and technical support representatives, and product support specialists around the world.

27 references 1. Posterior Implant Single-tooth Replacement and Status of Adjacent Teeth during a 10-year Period: A Retrospective Report. Misch CE, Misch-Dietsh F, Silc J, Barboza E, Cianciola EJ, Kazor C. J Periodontol Dec;79(12): A Bone-Quality Based Implant System: First Year Prosthetic Loading. Misch CE, Dietsh- Misch F, Hoar J, Beck G, Hazen R, Misch CM. J Oral Implantol. 1999;25(3): A Prospective Multi-Center Clinical Investigation of a Bone Quality-Based Dental Implant System. Kline R, Hoar JE, Beck GH, Hazen R, Resnik RR, Crawford EA. Implant Dent. 2002;11(3): April 30-May 4, New Orleans, LA. 4. Initial Clinical Efficacy of 3-mm Implants Immediately Placed into Function in Conditions of Limited Spacing. Reddy MS, O Neal SJ, Haigh S, Aponte-Wesson R, Geurs NC. Int J Oral Maxillofac Implants Mar-Apr;23(2): Immediate Functional and Non-functional Loading of Dental Implants: A 2- to 60-month Follow-up Study of 646 Titanium Implants. Degidi M, Piattelli A. J Periodontol Feb;74(2): Five-Year Prospective Study of Immediate/Early Loading of Fixed Prostheses in Completely Edentulous Jaws with a Bone Quality-Based Implant System. Misch CE, Degidi M. Clin Implant Dent Relat Res May;5(1): Comparative Analysis of Immediate Functional Loading and Immediate Nonfunctional Loading to Traditional Healing Periods: A 5-Year Follow-Up of 550 Dental Implants. Degidi M, Iezzi G, Perrotti V, Piattelli A. Clin Implant Dent Relat Res Sep;9. 8. Endosteal Implants in the Edentulous Posterior Maxilla: Rationale and Clinical Report. Misch CE, Poitras Y, Dietsh-Misch F. Oral Health Aug;8: Augmentation of the Maxillary Sinus with Calcium Sulfate: One-Year Clinical Report from a Prospective, Longitudinal Study. De Leonardis D, Pecora GE. Int J Oral and Maxillofac Implants Nov-Dec;14(6): Short Dental Implants in Posterior Partial Edentulism: A Multicenter Retrospective 6-year Case Series Study. Misch CE, Steignga J, Barboza E, Misch-Dietsh F, Cianciola LJ, Kazor C. J Periodontol Aug;77(8): Human Histologic Evidence of a Connective Tissue Attachment to a Dental Implant. M Nevins, ML Nevins, M Camelo, JL Boyesen, DM Kim. International Journal of Periodontics & Restorative Dentistry. Vol. 28, No. 2, Clinical Evaluation of Laser Microtexturing for Soft Tissue and Bone Attachment to Dental Implants. Pecora GE, Ceccarelli R, Bonelli M, Alexander H, Ricci JL. Implant Dent Feb;18(1): The effects of laser microtexturing of the implant collar upon crestal bone levels and periimplant health. S Botos, H Yousef, B Zweig, R Flinton. S Weiner. Accepted for publication in The International Journal of Oral and Maxillofacial Implants. 14. For a complete research summary, please see Laser-Lok Clinical Overview (BioHorizons document ML0606) 15. Radiographic Analysis of Crestal Bone Levels on Laser-Lok Collar Dental Implants. CA Shapoff, B Lahey, P Wasserlauf, D Kim. Int J Periodontics Restorative Dent 2010;30: Functional Surface Area: Thread-Form Parameter Optimization for Implant Body Design. J.Todd Strong, Carl E. Misch, DDS, MDS, Martha W. Bidez, PhD, Prasad Nalluri. Compendium / Special Issue. Vol 19, No. 3, Histologic and Histomorphometric Findings from Retrieved, Immediately Occlusally Loaded Implants in Humans. Romanos GE, Testori T, Degidi M, Piattelli A. J Periodontol Nov;76(11): Effects of Implant Thread Geometry on Percentage of Osseointegration and Resistance to Reverse Torque in the Tibia of Rabbits. Steigenga J, Al-Shammari K, Misch C, Nociti Jr. FH, Wang H-L. J Periodontol. 2004;75(9): Preliminary evaluation of a new dental implant design in canine models. Bumgardner JD, Boring JG, Cooper RC Jr, Gao C, Givaruangsawat S, Gilbert JA, Misch CM, Steflik DE. Implant Dent. 2000;9(3): Osseointegration on metallic implant surfaces: effects of microgeometry and growth factor treatment. SR Frenkel, J Simon, H Alexander, M Dennis, JL Ricci. J Biomed Res. 2002:63(6): Initial clinical efficacy of 3-mm implants immediately placed into function in conditions of limited spacing. Reddy MS, O Neal SJ, Haigh S, Aponte-Wesson R, Geurs NC. Int J Oral Maxillofac Implants Mar-Apr;23(2): Implant strength & fatigue testing done in accordance with ISO standard The Impact of Loads on Standard Diameter, Small Diameter and Mini Implants: A Comparative Laboratory Study. Allum SR, Tomlinson RA, Joshi R. Clin. Oral Impl. Res May;19(6): Retrospective multicenter analysis of immediate provisionalization using one-piece narrow-diameter (3.0-mm) implants. Sohn DS, Bae MS, Heo JU, Park JS, Yea SH, Romanos GE. Int J Oral Maxillofac Implants Jan-Feb;26(1): Adequate primary stability required. 26. Removing the abutment after initial placement may disrupt the connective tissue attachment. 27. Histologic evidence of a connective tissue attachment to laser microgrooved abutments: a canine study. M Nevins, DDS, DM Kim, DDS, DMSc, SH Jun, DDS, MS, K Guze, DMD, P Schupbach, PhD, ML Nevins, DMD, MMSc. Accepted for publication: IJPRD, Vol 30, Number 3, Postoperative Complications Following Gingival Augmentation Procedures. Griffin T, Cheung W, Zavaras A, Damoulis P. Journal of Periodontology. December Acellular Dermal Matrix for Mucogingival Surgery: A Meta-Analysis.R Gapski, CA Parks, HL Wang. J Periodontol. 2005;76(11): Reference manufacturer s Instructions for Use (IFU) package insert. 31. Acellular Dermal Matrix Graft as a Membrane for Guided Bone Regeneration: A Case Report. AB Novaes, SL Souza. Implant Dent. 2001;10(3): Management of Localized Buccal Dehiscence Defect with Allografts and Acellular Dermal Matrix. Park, Sang-Hooh, Wang, Hom-Lay. The International Journal of Periodontics & Restorative Dentistry. 2006;26: Acellular Dermal Matrix as a Barrier in Guided Bone Regeneration: a Clinical, Radiographic and Histomorphometric Study in Dogs. Borges, G.J., Novaes, A.B. Jr, de Moraes Grisi, M.F., Palioto, D.B., Taba, M. Jr, de Souza, S.L.S. Clin. Oral Impl. Res Grafton DBM forms and Grafton Plus DBM Paste are FDA 510(k) cleared for use as a bone void filler, bone graft extender and bone graft substitute. 35. Histologic Analysis of Implant Sites after Grafting with Demineralized Bone matrix putty and sheets. Callan, D.P., Salked, S.L., Scarborough, N.L. Implant Dent. 2009;9(1): Bone forming activity exhibited in this in vivo model should not be interpreted as a predictor of clinical performance. 37. A Resorbable, Reconstituted Type I Collagen Membrane for Guided Tissue Regeneration and Soft Tissue Augmentation. Yuen, D, Junchaya, C, Zuclich, G, Ulreich, J.B., Lin, Horng-Ban, Li, Shu-Ti. Society for Biomaterials. 2000; Prediction of In Vivo Stability of a Resorbable, Reconstituted Type I Collagen Membrane by In Vitro Methods. JB Ulreich, G Zuclich, HB Lin, ST Li Society World Biomaterials Congress Transactions, Sixth World Biomaterials Congress Transactions. Not all products shown or described in this literature are available in all countries. BioHorizons, Laser-Lok, MinerOss, Autotac and Mem-Lok are registered trademarks of BioHorizons, Inc. Spiralock is a registered trademark of Spiralock Corporation. Grafton DBM and LADDEC are registered trademarks of Osteotech, Inc. AlloDerm, AlloDerm GBR and LifeCell are registered trademarks of LifeCell Corporation. Mem-Lok is manufactured by Collagen Matrix, Inc. As applicable, BioHorizons products are cleared for sale in the European Union under the EU Medical Device Directive 93/42/EEC and the tissues and cells Directive 2004/23/EC. We are proud to be registered to ISO 13485:2003, the international quality management system standard for medical devices, which supports and maintains our product licences with Health Canada and in other markets around the globe. Original language is English BioHorizons, Inc. All Rights Reserved.

28 Direct Offices Distributors BioHorizons USA or BioHorizons Canada BioHorizons Germany BioHorizons Spain BioHorizons Australia BioHorizons UK +44 (0) BioHorizons Chile For contact information in our 85 markets, visit s h o p o n l i n e a t w w w. b i o h o r i z o n s. c o m *ML0309* ML0309 REV D APR 2011

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