İzmir Katip Çelebi University, Faculty of Engineering & Architecture Department of Biomedical Engineering

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1 Utku Kürşat Ercan, Ph.D. Assistant Professor, İzmir Katip Çelebi University, Faculty of Engineering & Architecture Department of Biomedical Engineering Phone: (ext: 3747) Mobile: Contact Information: İzmir Katip Çelebi Üniversitesi Çiğli Ana Yerleşkesi İzmir/Turkey Research Interests: Plasma Medicine, Biomedical Engineering, Disinfection Effect of Non- Thermal Plasma, Plasma Chemistry, Plasma Physics, Hospital Acquired Infections, Infection Control, Novel Antimicrobial Agents Education: Drexel University, Philadelphia PA, USA Ph.D., School of Biomedical Engineering, Science and Health Systems, Thesis Title: Mechanisms Underlying Antimicrobial Efficacies of Non- Thermal Dielectric Barrier Discharge (DBD) Plasma- Treated N- Acetyl Cysteine Solution Advisor: Suresh G. Joshi, MD, PhD Co- advisors: Kenneth A. Barbee, PhD Ari D. Brooks, MD Ege University, Izmir, Turkey B.Sc., Bioengineering, Advisor: Ismet Deliloglu Gurhan, PhD Professional Experience: İzmir Katip Çelebi University, Faculty of Engineering and Architecture Department of Biomedical Engineering, İzmir, Turkey Assistant Professor August, İzmir Katip Çelebi University, Faculty of Engineering and Architecture Department of Biomedical Engineering, İzmir, Turkey Lecturer, January, 2014 August, 2014 Drexel University, College of Medicine, Department of Surgery, Infection Control Laboratory, Philadelphia PA, USA 1

2 Research Assistant, March, 2009 August, 2013 Drexel University, A.J.Drexel Plasma Institute, Camden NJ USA Research Assistant, March, 2009 August, 2013 Dokuz Eylul University, Health Sciences Institute, Department of Biomechanics Research Assistant, August, 2006 March 2008 Publications: Journal Papers: Ercan UK, Joshi SS, Gogotsi N, O Toole S, Paff M, Melchior E, Joshi SG. Multidrug- resistant- biofilm inhibitory efficacies of non- thermal plasma treated novel solutions. Advances in Microbiology. In press. Ercan UK, Smith J, Ji H, Brooks AD, Joshi SG. Chemical Species in Plasma- Treated N- Acetylcysteine (NAC) Solution and Their Contribution to Microbial Inactivation. Under Review Albala L, Ercan UK, Joshi SG, Wheatley MA. Indirect Plasma Sterilization of Ultrasound Contrast Agent. Biotechnology and Bioengineering. Under Review Kojtari A, Ercan UK, Smith J, Brooks AD, Ji H, Joshi SG. Chemistry for Antimicrobial Effects of Non- Thermal DBD Plasma Treated Water. Nanomedicine & Biotherapeutic Discovery. 2013;4(1): Zhang Z, Nix CA, Ercan UK, Gerstenhaber JA, Joshi SG, Zhong Y. Calcium binding- mediated sustained release of minocycline from hydrophilic multilayer coatings to target medical device- related infection and inflammation. PLoS ONE. 2014; 9(1): e Neidrauer M, Ercan UK, Bhattacharyya A, Trikha R, Barbee KA, Joshi SG. Antimicrobial Efficacy of a Topical Ointment Containing Nitric Oxide- Loaded Zeolite. Journal of Medical Microbiology. 2014; 63(Pt2):203-9 Poor A, Ercan UK, Yost A, Brooks AD, Joshi SG. Microbial and cellular responses to nonthermal plasma- treated alginate wound dressing: control of multidrug- resistant pathogens. 2014; 15(3): Ercan UK, Wang H, Ji H, Fridman G, Brooks AD, Joshi SG. Nonequilibrium plasma- activated antimicrobial solutions are broad- spectrum and retain their efficacies for extended period of time. Plasma Process and Polymers. 2013;10(6): Shainsky N, Dobrynin D, Ercan UK, Joshi SG, Brooks, AD, Fridman G, Cho Y, Fridman A, Friedman G. Plasma Acid: Water treated by dielectric barrier discharge. Plasma Process and Polymers. 2012;9(6) 2

3 Celik EU, Ergucu Z, Turkun LS, Ercan UK, Tensile bond strength of an aged resin composite repaired with different protocols. Journal of Adhesive Dentsitry 2011 Aug;13(4): Joshi SG, Cooper M, Yost A, Paff M, Ercan UK, Fridman G, Friedman G, Fridman A, Brooks AD. Nonthermal dielectric- barrier discharge plasma- induced inactivation involves oxidative DNA damage and membrane lipid peroxidation in Escherichia coli. Antimicrobial Agents Chemotherapy 2011 Mar;55(3): Conference Proceedings: Ji H, Li Y, Kojtari A, Ercan UK, Smith J, Friedman G, Fridman A, Sensenig RB, Tyagi S, Joshi SG, Brooks AD, Plasma Chemistry for Suitability and Environmental Safety. International Summit on Past and Present Research Systems of Green Chemistry, August 25-27, 2014, Philadelphia, PA, USA (Oral Presentation) Albala L, Wheatley M, Joshi SG, Ercan UK, Indirect Plasma Sterilization of Ultrasound Contrast Agent. International Symposium on Molecular Medicine and Infectious Disease, June 16-20, 2014, Philadelphia, PA, USA (Poster presentation) Ercan UK, Ji H, Brooks A, Joshi SG, Non- Thermal Plasma- Activated N- Acetyl- Cysteine Solution as a Novel Broad Spectrum Antimicrobial Agent. International Symposium on Molecular Medicine and Infectious Disease, June 16-20, 2014, Philadelphia, PA, USA (Poster presentation) Ercan UK, Ji H, Brooks AD, Joshi SG, Chemical Responses in Escherichia coli upon Exposure to Non- Thermal DBD Plasma- Treated N- Acetylcysteine (NAC) Solution. ICPM- 5, 5 th International Conference of Plasma Medicine, May 18-23, 2014, Nara, Japan (Poster presentation) Ercan UK, Ji H, Brooks AD, Joshi SG, NAC Solution Activated by non- thermal DBD plasma is highly antimicrobial and mounts predominantly nitrosative stress in Escherichia coli. ASM- 2014, International Conference of American Society for Microbiology, May17-20, 2014, Boston, MA, USA. (Poster presentation) Ercan UK, Smith J, Ji F, Brooks AD, Joshi SG, Chemical Changes in Plasma- Treated NAC Solution, Leading to Antimicrobial Effect. XIX International BIOMED Symposium, November 12-15, 2013, Kusadasi, Turkey (Oral Presentation) Neidrauer M, Ercan UK, Bhattacharyya A, Barbee KA, Joshi SG, Antimicrobial Efficacy of a Topical Ointment Containing Nitric Oxide Loaded Zeolite. Wound Healing Society Annual Meeting, May 1-5, 2013, Denver CO, USA (Poster Presentation) 3

4 Ercan UK, Fridman G, Brooks AD, Joshi SG, Non- Thermal Dielectric Barrier (DBD) Plasma Treated N- Acetylcysteine (NAC) Solution: A Novel Antimicrobial Agent. Annual Meeting of Surgical Infection Society, April 12-15, 2013, Las Vegas NV, USA (Poster Presentation) Ercan UK, Kojtari A, Ji H, Fridman G, Brooks AD, Joshi SG, Chemical Modifications in Non- Thermal DBD Plasma Treated Water and Antimicrobial Effects. 4 th International Conference on Plasma Medicine, June 17-21, 2012, Orleans, France (Poster Presentation) Ercan UK, Wang H, Ji H, Fridman G, Brooks AD, Joshi SG, Antimicrobial Properties of NAC Treated by Non- Thermal DBD Plasma. International Symposium on Molecular Medicine and Infectious Disease, June 19-21, 2012, Philadelphia PA, USA (Poster Presentation) Yost AD, Ercan UK, Mahmood S, Poor A, Brooks AD, Joshi SG, Effects of Alginate Gels Treated with Non- Thermal Dielectric Barrier Discharge Plasma on Endothelial Cell Migration and Proliferation. International Symposium on Molecular Medicine and Infectious Disease, June 19-21, 2012, Philadelphia PA, USA (Poster Presentation) Poor A, Ercan UK, Joshi SG, Fridman A, Fridman G, Friedman G, Brooks AD, Alginate Gels Treated With Nonthermal Plasma: A Novel Wound Dressing. 7th Annual Academic Surgical Congress, February 14-16, 2012, Las Vegas NV, USA (Poster presentation) Shainsky N, Dobrynin D, Ercan UK, Park S, Joshi SG, Ji H, Brooks AD, Cho Y, Fridman G, Fridman A, Friedman G, Plasma Acid: A Chemically and Physically Metastable Substance, 64th Annual Gaseous Electronics Conference, November 14 18, 2011; Salt Lake City UT, USA (Oral presentation) Poor AE, Ercan UK, Fridman G, Fridman G, Friedman G, Brooks AD, Joshi SG. Antimicrobial Efficacy of Non- Thermal Plasma- Treated Alginate Wound- Dressing Against Multidrug Resistant Pathogens. IDSA 2011 Annual Meeting, October 20-23, 2011, Boston MA, USA (Poster Presentation) Ercan UK, Fridman G, Brooks AD, Joshi SG, Antimicrobial Behavior of Non- Thermal Plasma Treated Liquids. International Symposium on Plasma Chemistry, ISPC 20, August 4-9, 2011, Philadelphia PA, USA (Poster Presentation) Shainsky N, Dobrynin D, Ercan UK, Joshi SG, Ji H, Brooks AD, Fridman G, Fridman A, Friedman G, Inactivation of Escherichia Coli: Pharmacological Effect of Non- Equilibrium Plasma Treatment of Liquids. International Symposium on Plasma Chemistry, ISPC 20, August 4-9, 2011, Philadelphia PA, USA (Poster Presentation) 4

5 Shainsky N, Dobrynin D, Ercan UK, Joshi SG, Brooks AD, Ji H, Fridman G, Young C, Fridman A, Friedman G, Plasma acid and its applications. International Conference on Plasma Science (ICOPS), June 26-30, 2011, Chicago IL, USA (Poster Presentation) Ercan UK. O Toole S, Gogotsi N, Fridman G, Brooks AD, Joshi SG, Non- thermal Floating Electrode- DBD Plasma: A Novel Approach to Control Bacteria in Biofilms. Surgical Infection Control of North America, Annual Meeting, May 11-14, 2011 Palm Beach FL, USA. (Poster Presentation) Shainsky N, Dobrynin D, Ercan UK, Joshi SG, Ji H, Brooks AD, Fridman G, Fridman A, Friedman G, Pharmacological Effect of Non- Equilibrium Plasma Treatment of Liquids Drexel University IEEE graduate forum s 4 th annual research symposium March 3, 2011, Philadelphia PA, USA (Poster Presentation) Shainsky N, Dobrynin D, Ercan UK, Joshi SG, Fridman G, Friedman G, Fridman A, Effect of Liquid Modified by Non- Equilibrium Atmospheric Plasmas on Bacteria Inactivation Rates. ICOPS 2010, June 20-24, 2010, Norfolk, Virginia, USA (Poster Presentation) Ercan UK, Cecen B, Uzun B, Mutlu I, Baran O, Havitcioglu H, Biomechanical Properties of Peripheral Neural Tissue; 20th Turkish National Orthopedics and Traumatology Congress, October, Ankara, Turkey, 23-28, 2007 Acta Orthopedica Traumatolica Turcica, Supplementum III, p. 138 Cecen B, Ates H, Inci I, Ercan UK, Mutlu I, Yenigul M, Ozcanhan MH, Mechanical Stimulation of Osteoblasts by Ultrasonic Waves; 20th Turkish National Orthopedics and Traumatology Congress, October, Ankara, Turkey, 23-28, 2007 Acta Orthopedica Traumatolica Turcica, Supplementum III p. 136 Mutlu I, Ates H, Inci I, Ercan UK, Cecen B, Yenigul M, Ozcanhan MH, Unidirectional and Cyclic Mechanical Stimulation of Osteoblasts Cultured on Collagen Scaffolds Covered by PLA, 20th Turkish National Orthopedics and Traumatology Congress, October, Ankara, Turkey, 23-28, 2007, Acta Orthopedica Traumatolica Turcica, Supplementum III p. 26 Patents: Materials for Disinfection Produced by Non- thermal Plasma. Publication No: WO/2012/ Publication Date: International Application No: PCT/US2011/ International Filling Date:

6 Awards and Honors: Scholarship for Masters and Ph.D. in Foreign Countries, Republic of Turkey, Ministry of National Education, for 5 years ( ) First Place in the Drexel s IEEE poster competition, Drexel University IEEE graduate forum s 4 th annual research symposium March 3, 2011, Philadelphia PA, USA Professional Memberships: International Society of Plasma Medicine May Present Institute of Electrical and Electronics Engineers January 2012 Present International Society of Plasma Chemistry July 2011 Present Skills: Programming & Software: ANSYS, Autodesk Inventor, Chemical WorkBench, ChemKin, MS Office, iwork, ilife Language: Turkish (Native), English (Fluent, TOEFL IBT: 97) 6