Analgesics Dosage/Frequency/Duration Max Volume/A/S Route
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1 Animal Care Unit Pharmaceuticals For Use In Laboratory Animals NOTES: 1. Where appropriate, dilute all medications to an appropriate workable volume based on species. 2. Refer to a published formulary to confirm doses where a wide dose range or multiple dosing routes are listed. 3. Doses listed are based upon Carpenter s Exotic Animal Formulary, 4 th Edition, 2012 (Elsevier, Saunders). Analgesics Dosage/Frequency/Duration Max Volume/A/S Route Meloxicam 1-5mg/kg q24hrs (Diluted) 100ul PO or SC 1-2mg/kg q24hrs Butorphanol 0.2mg/kg SC, IM q24hrs 0.3mg/kg PO q24hrs x 10days 0.2-2mg/kg q2-4hrs 100ul SC/IM/PO SC/IM/IP Buprenorphine 0.1 5mg/kg q4-6 hours mg/kg q6-12hrs 500ul SC/IM/IV SC mg/kg q6-12hrs SC/IV/IP Proparacaine mg/kg q6-12hrs 0.01ml each eye 500ul 0.03ml each eye SC/IV/IP ly (eye) Lidocaine Rats/ 1 drop each eye Mice/Rats/ 1mg/kg as needed. Maximum total dose 10mg/kg as single infusion. Rats/ 3 drops each eye 200ul Rats/ 0.5-3ml SC
2 Antibiotics/ Antimycotics Trimethoprim/ Sulfamethoxazole Ampicillin Dosage/Frequency/Duration Max Volume/A/S Route 15-30mg/kg q12h As per SOP PO Mice & Rats ONLY: mg/kg q8hrs 150ul/dose 200ul/dose PO, SC, IM Enrofloxacin 5-20mg/kg q12h up to 14days /dose /dose PO/ SC/IM 5mg/kg q12-24hrs 500ul/dose IM/IV Tylosin 10mg/kg PO, SC q12hrs 10mg/kg IM, q24hrs /dose /dose PO/SC/IM Miconazole/ Polymyxin/ Prednisolone ( SUROLAN ) Gentamicin Sulfate 10mg/kg PO, SC, IM q12-24hrs Mice/Rats/ 1-3 drops per site q24hrs, days 2-4mg/kg q8-24hrs As per SOP 1-3 drops/dose/site 150ul/dose 200ul/dose PO/SC/IM SC, IM Gentamicin/ Beta-methasone ( Topagen spray) Gentamicin/ Beta-methasone ( Pentasone ophthalmic) Ketoconazole Neomycin/ Poly-mxin B/ Bacitracin ointment ( Neosporin ) 1ml/dose 5-8mg/kg q24hrs 1 pump per site q12hrs, 3-14days 2 pumps per site per day 1 drop/eye q12hrs, 3-14days 2 drops per eye per day Mice, Rats, 10-40mg/kg per day, 14days Mice/ 1mm strip per 1cm lesion, q12hrs 1mm strip per 1cm lesion, q6hrs As per SOP 2mm strip per 1cm lesion PO
3 Anaesthetics/ Dosage/Frequency/Duration Max Volume/A/S Route Sedatives Isofluorane ( Isoflo ) 1-5% delivered with oxygen To effect Inhalant Acepromazine ( Atravet ) 0.5-1mg/kg, once IM Ketamine ( Vetalar, Ketalean ) mg/kg once Mice/ mg/kg 1ml IM, SC IM/IP Diazepam ( Valium ) 15-50mg/kg mg/kg to effect 1ml IM, IV IM Midazolam ( Versed ) 1-5mg/kg to effect 1-2mg/kg to effect 1ml IM, IV IM Xylazine ( Rompun ) 1-2mg/kg to effect 5-10mg/kg 1ml IM, IV IP Medetomidine ( Domitor ) 1-5mg/kg mg/kg SC 1ml IM/SC SC Dexmedetomidine ( Dexdomitor ) mg/kg Mice/Rats 0.5mg/kg mg/kg 1ml 1ml IM. IP Usually used in combination w/ketamine SC/IM:
4 Anaesthetics/ Sedatives Atipamezole ( Antisedan ) Dosage/Frequency/Duration Max Volume/A/S Route 1-2.5mg/kg SC/IP Sodium Pentobarbital ( Euthanyl ) *Not recommended for anaesthesia use for euthanasia only mg/kg 50-90mg/kg IP 30-45mg/kg IP 20-45mg/kg IV, IP 1ml Body weight dependent IM, SC, IV IP IV, IP Other Medications Dosage/Frequency/Duration Max Volume/A/S Route Epinephrine 0.1mg/kg IV 100ul IV Atropine 0.2mg/kg IV mg/kg intratracheally mg/kg SC q15-60 mins for bradycardia 0.4mg/kg SC, IM 0.5-5ml IV/ intratracheal SC, IM Furosemide mg/kg SC, IM 0.1-3mg/kg SC 0.8-1mg/kg IM q10-15 minutes as needed for bradycardia Mice/ 5-10 mg/kg SC, IM q12hrs 1ml SC/IM PO, SC, IM, IV Fenbendazole (antiparasitic) 2-5 mg/kg PO, SC, IM, IV q12hrs as needed 20-50mg/kg PO q24hrs x 5days 5-20mg/kg PO q24h for 5 days, repeat in 14days 1ml Mice, Rats, deliver as medicated feed PO/SC/IM/IV PO
5 Other Medications Dosage/Frequency/Duration Max Volume/A/S Route 50% dextrose q2-3h as needed: 500ul/24hrs PO Mice ~100ul Rats ~1ml Rabbits ~3ml 5ml/24hrs 15ml/24hrs Heparin U/kg every 12 hrs 1ml SC
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