Chronic Headaches. David R. Greeley, MD, FAAN Northwest Neurological, PLLC October 23, 2015
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1 s David R. Greeley, MD, FAAN Northwest Neurological, PLLC October 23, 2015
2 Why is Headache Important? 36,000,000 people have migraine - more than asthma and diabetes combined 13,000,000 have chronic daily headache 4,000,000 have > 15 migraines per month
3 Common family history of: - chronic pain - chronic headache - psychiatric concerns - abuse Learned behavior on medication use/abuse
4 The Cycle chronic pain poor sleep depression
5 Adverse Childhood Experiences
6 - a multifactorial approach - A contract for therapy - Education - Exercise - Sleep - Physical modalities - Psychiatric management - Avoidance of ER s and Urgent Care - Dietary changes - Medication
7 - a multifactorial approach - A contract for therapy - Education - Exercise - Sleep - Physical modalities - Psychiatric management - Avoidance of ER s and Urgent Care - Dietary changes - Medication
8 - a multifactorial approach - A contract for therapy - Education - Exercise - Sleep - Physical modalities - Psychiatric management - Avoidance of ER s and Urgent Care - Dietary changes - Medication
9 Exercise - regular, not excessive - simple, cheap and enjoyable - Yoga, T ai Chi, water aerobics...
10 - a multifactorial approach - A contract for therapy - Education - Exercise - Sleep - Physical modalities - Psychiatric management - Avoidance of ER s and Urgent Care - Dietary changes - Medication
11 Sleep hygiene - sleep consolidation - avoidance of stimulants - regular and consistent behavior - light box - overnight oximetry - Belsomra
12 - a multifactorial approach - A contract for therapy - Education - Exercise - Sleep - Physical modalities - Psychiatric management - Avoidance of ER s and Urgent Care - Dietary changes - Medication
13 Physical Modalities - physical therapy - chiropractic - therapeutic massage - acupuncture - craniosacral therapy - Rolfing / Structural Integration
14 - a multifactorial approach - A contract for therapy - Education - Exercise - Sleep - Physical modalities - Psychiatric management - Avoidance of ER s and Urgent Care - Dietary changes - Medication
15 Behavioral / Psychological / Psychiatric - Counseling - Listening - Support - Biofeedback / Meditation - Limited medicines
16 - a multifactorial approach - A contract for therapy - Education - Exercise - Sleep - Physical modalities - Psychiatric management - Avoidance of ER s and Urgent Care - Dietary changes - Medication
17 - a multifactorial approach - A contract for therapy - Education - Exercise - Sleep - Physical modalities - Psychiatric management - Avoidance of ER s and Urgent Care - Dietary changes - Medication
18 Dietary changes - hydration -- half your weight in oz/d - eating healthy foods - supplements as necessary -? allergies -- IgG from US Biotek - elimination diets - gluten-free - Naturopathic medicine
19 US Biotek Most common IgG markers in migraine patients: dairy and chicken egg In one study dietary elimination of these two improved migraine by >80% in >80% of patients
20 Rx -- acute care medications - steroid tapers - trigger point injections - Midrin (isometheptene mucate, dichloralphenazone and acetaminophen) - triptans - opioids
21 Rx -- chronic preventive medications - AED s - Tricyclics - Beta Blockers - Calcium Channel Blockers - others - research
22 AED s (anti-epileptic drugs) - topiramate (Topamax ) - divalproex (Depakote ) - lamotrigine (Lamictal ) - gabapentin (Neurontin ) - pregabalin (Lyrica )
23 TCA s (tricyclic antidepressants) - amitriptyline - imitriptyline - notriptyline - despiramine
24 Beta Blockers - propranolol - timolol - atenolol - metoprolol - nadolol
25 Calcium Channel Blockers - verapamil - diltiazem - amlodipine - nimodipine
26 Non-Prescription Agents Migrelief Petadolex Gliacin Zira Nourished Mind turmeric melatonin
27 Other Rx for Headache ACE inhibitors acetazolamide angiotensin II receptor antagonists (ARBs candesartan) clonidine indomethacin Namenda neuroleptics opioids oxytocin prazosin SSRI/SNRI
28 Botox in Migraine Botox has been used for neurological diseases for >20 years Treatment for spasticity led to: - improvement in hyperhidrosis Treatment for blepharospasm led to improvement in: - wrinkles - migraine
29 Botox in Migraine FDA-approved protocol 80+% reduction in headache 31 injections x5 units every weeks: - 7: corrugator, procerus, frontalis - 8: temporalis - 6: occipitalis - 4: paracervical - 6: trapezius
30 Calcitonin Gene-Related Peptide Member of the calcitonin family α and β forms 37 amino acids derived from cell bodies of spinal cord motor neurons helps with regeneration derived from dorsal root ganglia linked to transmission of pain derived from trigeminal ganglion involved in migraine involved in cardiovascular homeostasis
31 CGRP in Migraine Meningeal nociceptors from the trigeminal ganglion release CGRP CGRP binds to CGRP receptors on meningeal vessels potent neurogenic vasodilator Triptans block CGRP acutely Botox prevents release of CGRP by cleavage of SNAP-25 protein monoclonal antibodies block CGRP after monthly infusion
32 CGRP Research Phase III study 825 patients nationwide Northwest Neurological is local site Patients with acute and chronic migraine Once a month infusion vs placebo Beginning enrollment in November 2015
33 Why is Headache Important? 36,000,000 people have migraine - more than asthma and diabetes combined 13,000,000 have chronic daily headache 4,000,000 have > 15 migraines per month
34 s QUESTIONS? David R. Greeley, MD Northwest Neurological, PLLC
35 Northwest Neurological, PLLC Jason Aldred, MD Anne-Marie Bergeleen, ARNP David Duba, MD Jeff Emery, DO Tim Gilreath, LMP David Greeley, MD Jamie Mark, ARNP
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