CURRICULUM VITAE. Mr Thierry D. Pache, MBA, MD, PhD

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1 CURRICULUM VITAE Mr Thierry D. Pache, MBA, MD, PhD February

2 CURRICULUM VITAE Family name Pache Christian name Thierry Daniel Date of birth 5th of June 1956 Nationality Swiss Origin from Lausanne (VD) and Ecublens (FR), Switzerland Marital status married, 3 children Home address La Williamine, CH-1095 Lutry, Switzerland Ob/gyn practice Ch de la Prairie 2, CH-1815 Clarens/Montreux, Switzerland Tel + fax /01 (Fax) mmc@montreuxmenopause.com Av. Adrien Lachenal 12, CH-1207 Geneva, Switzerland Schools attended Certificates Medical education Medical degrees 1967 to 1973, Collège secondaire, Lausanne 1973 to 1976, Gymnase du Belvédère, Lausanne 1973, Certificat d études secondaires 1976, Baccalauréat ès lettres (Langues Modernes) 1976, Certificat (D) de Maturité Fédérale 2010, MBA (marketing) UNIVERSITY OF LIVERPOOL, UK 1976 to 1983, UNIVERSITY OF LAUSANNE MEDICAL SCHOOL, Switzerland , pre-graduate clinical training in Switzerland (UNIVERSITY OF LAUSANNE), in Canada (MONTREAL UNIVERSITY), U.S.A. (STATE UNIVERSITY OF NEW YORK AT BUFFALO & HARVARD MEDICAL SCHOOL), Central America (UNIVERSIDAD DE COSTA-RICA) 1984, Diplôme Fédéral de Médecin, UNIVERSITY OF LAUSANNE MEDICAL SCHOOL, Switzerland 1988, Certificat Universitaire en Echographie Gynécologique et Obstétricale, UNIVERSITY LOUIS PASTEUR, Strasbourg, France 1989, MD, Doctorat en Médecine, UNIVERSITY OF LAUSANNE, Switzerland 1990, Certificate in training for clinical trials, ERASMUS UNIVERSITY, Rotterdam, The Netherlands 1993, Ph.D. (gynaecological endocrinology), ERASMUS UNIVERSITY, Rotterdam 1993, Spécialiste FMH (Foederatio Medicorum Helveticorum) en Gynécologie et Obstétrique, Switzerland 2002, Spécialiste FMH Médecine de la Reproduction et endocrinologie gynécologique 2005, Predictive Medicine Inter-University Diploma, UNIVERSITY OF NANCY & UNIVERSITY OF PARIS VII, France American Academy of Cosmetic Gynecologists Certificate, U.S.A. Languages French, mother language -Fluency in English Fluency in Italian -Fluency in Spanish Fluency in Dutch -German PREVIOUS APPOINTMENTS 2

3 From May 1984 to September 1984 Private practice in General Medicine, Les Diablerets, Switzerland (Dr.J.Daubercie) From October to March 1985 Resident, Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland Prof Dr N.de Tribolet, Chairman. Prof Dr R.Campiche) From April 1985 to March 1986 Resident, Department of General Surgery, Hôpital de Morges, Morges, Switzerland (Prof Dr G.Chapuis, Dr P Babaiantz, Dr A Boitzy) From April 1986 to September 1986 Resident, Department of E.N.T. and Neck Surgery, CHUV (Prof Dr M. Savary, Chairman) From October 1986 to March 1989 Resident and chief resident, Department of Gynaecology and Obstétrics, Hôpital de Morges (Dr R. Born, Dr P.Y.Dubuis ) From April 1989 to September 1991 Resident, Department of Gynaecology and Obstetrics, Dijkzigt Academic Hospital, Rotterdam, The Netherlands (Prof Dr A.C. Drogendijk, Chairman, Prof Dr H.C.S. Wallenburg, Prof Dr J.W. Wladimiroff ) Clinical Research Fellow, Section of Reproductive Endocrinology and Infertility, Department of Gynaecology and Obstetrics, Dijkzigt Academic Hospital ( Head, Dr B.C.J.M.Fauser ) From October 1991 to October 1993 Resident, chief resident, chef de clinique adjoint, Department of Gynaecology and Obstetrics, CHUV (Prof Dr P. de Grandi, Chairman, Prof Dr H.Bossart) From November 1993 to August 1995 Resident, chef de clinique, Department of Obstetrics and Gynaecology, University Cantonal Hospital (HCUG), Geneva, Switzerland (Prof Dr A.Campana, Chairman. Prof Dr F.Béguin, Prof Dr F.Krauer ). From April the 1st of 1994, in the Clinic for Infertility and Gynaecologic Endocrinology, HCUG Prof Dr A.Campana) SEPTEMBER SEPTEMBER Consultant, Clinic for Infertility and Gynaecologic Endocrinology, WHO Collaborating Centre for Research in Human Reproduction, Department of Gynaecology and Obstetrics, University Hospital, Geneva, Switzerland - Chargé d Enseignement, Geneva University School of Medicine, Geneva, Switzerland - Obstetrics and gynecology practice, Clarens/Montreux, Switzerland - Director, Montreux Menopause Center, Montreux, Switzerland - Consultant, Vanderlick Montchoisi IVF Center, Lausanne, Switzerland OCTOBER 2001 JANUARY Consultant, Molecular Diagnosis Center (Cdm), Fribourg, Switzerland ( ) - Consultant, Reproductive Medicine & IVF Center, Clinique Montchoisi, Lausanne Switzerland ( ) - Consultant, Reproductive Medicine & IVF Center, Clinique La Source, Lausanne, Switzerland ( ) - Private practice, Obstetrics and Gynaecology in Clarens/Montreux-Switzerland ( Director, (& Founder) Montreux Menopause Center MMC, Ch. de la Prairie 2, 1815 Clarens/Montreux Switzerland ( Consultant,Gynaecological endocrinology and Reproductive Medicine, CLINIQUE LA PRAIRIE, Montreux, Switzerland ( Consultant, & Teaching Surgery Staff, Obstetrics and Gynaecology Department, State Hospital Chablais, Aigle, Switzerland ( Consultant, GENE PREDICTIS, Center for Predictive Medicine, Site EPFL, PSE-B, 1015 Lausanne, Switzerland ( Private Practice Consultant Gynecology, Harley Str. 100/120, London, UK (GMC No ) ( ) - Private Practice Consultant, Av. Adrien Lachenal 12, 1207 Geneva, Switzerland ( Member of the Board, THE SWISS MENOPAUSE SOCIETY (2010-3

4 PROFESSIONAL AFFILIATIONS - Foederation Medicorum Helveticum ( Société suisse de Gynécologie et Obstétrique ( Swiss Bone and Mineral Society ( Société Suisse d Ultrason en Médecine et Biologie ( Société Suisse de Fertilité-Stérilité et de Planning Familial ( Société Suisse d Endocrinologie ( Société Vaudoise de Médecine ( Société Suisse de Ménopause ( Groupement d Etudes Biologiques Lausanne ( ) - Association Française pour l étude de la Ménopause ( Nederlands-Belgische Vereniging voor Fertiliteitsstudie ( ) - European Society of Human Reproduction and Embryology (Special Interest Group on Reproductive Endocrinology) ( International Menopause Society ( North American Menopause Society ( American Society for Reproductive Medicine (special Interest Group on Menopause) ( ) - American Institute of Ultrasound in Medicine ( Society for the Study of Reproduction ( ) - The Endocrine Society ( The New-York Academy of Sciences ( ) - American Academy of Cosmetic Gynecologists ( PERSONNALIA - INTERNATIONAL BOARDS - Clinical Research Grant in Reproductive Endocrinology (Fonds Louis Reymond), Société Académique Vaudoise, Lausanne, Switzerland - Co-editor-in-chief (founding editor), ULTRASOUND INTERNATIONAL, New-Dehli, India ( ) - Co-editor-in-chief, GENESIS, Revue de Gynécologie Obstétrique et Endocrinologie, Paris, France ( ) - Member, Nominating Committee for the Menopause Special Interest Group ( ), The American Fertility Society. (as of today AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE) - Consultant, Solvay Board. R & D Menopause. Berne, Switzerland ( ) - Teaching staff, Gynaecology and Reproductive Endocrinology. Subriez School for Nurses, Vevey, Switzerland ( ) - Vice Chairman of the Board, PASS THE BATON. Foundation for Organ Donors ( ) - Chairman of the Board, (Founding Member) GENE PREDICTIS Society for Predictive Medicine. Site EPFL, PSE-B, 1015 Lausanne, Switzerland ( Vice Chairman of the Board, ARGOT LAB Society for Pathology and Cytology, Lausanne Switzerland ( ) - Chairman of the Board, LIONEL PERRIER FOUNDATION, Foundation for Research in Brain Cancer, Montreux, Switzerland ( ) - JAN & OSCAR FOUNDATION, member of the Board/Vice-President (Founding Member) ( Member of the Board (Founding Member), GENE PATH, Society for Molecular Pathology, Lausanne, Switzerland ( ) - Member of the Board, SWISS SOCIETY OF MENOPAUSE (2010 LIST OF PUBLICATIONS ORIGINAL PAPERS TD Pache, JW Wladimiroff, FH de Jong, WC Hop, BCJM Fauser. Growth patterns of non-dominant ovarian follicles during the normal menstrual cycle. Fertility and Sterility 1990;54: TD Pache. Recherche et enseignement façonneraient notre avenir. Proposition d un médecin-assistant. Bulletin des médecins suisses 1990;71:

5 BCJM Fauser, TD Pache, SWJ Lamberts, WCJ Hop, FH de Jong, KD Dahl. Serum bioactive and immunoreactive luteinizing hormone and follicle-stimulating hormone levels in woman with cycle abnormalities, with or without polycystic ovarian disease. Journal of Clinical Endocrinology and Metabolism 1991;73: TD Pache, WCJ Hop, JW Wladimiroff, J Schipper, BCJM Fauser. Transvaginal sonography and abnormal ovarian appearance in menstrual cycle disturbances. Ultrasound in Medicine and and Biology 1991;17: TD Pache, S Chadha, LJG Gooren, WCJ Hop, KW Jaarsma, HBR Dommerholt, BCJM Fauser. Ovarian morphology in long term androgen treated female to male transsexuals. A human model for the study of polycystic ovarian syndrome? Histopathology 1991;19: TD Pache, WCJ Hop, JW Wladimiroff, BCJM Fauser. How to discriminate between normal and polycystic ovaries. A transvaginal ultrasound study. Radiology 1992;183:421-3 DC Schoot, TD Pache, WCJ Hop, FH de Jong, BCJM Fauser. Growth patterns of ovarian follicles during induction of ovulation with decreasing doses of human menopausal gonadotropin following presumed selection in polycystic ovary syndrome patients. Fertility and Sterility 1992;57: TD Pache, WCJ Hop, FH de Jong, RA Leerentveld, H van Geldorp, LJG Gooren, TMM v de Kamp, BCJM Fauser. 17-β estradiol, androstenedione, and inhibin levels in fluid from individual follicles of normal and polycystic ovaries, and of ovaries from female to male transsexuals. Clinical Endocrinology (Oxf) 1992;36: BCJM Fauser & TD Pache. Echoscopische monitoring van ovariele follikelgroei. Nederlands Tijdschrift voor Obstetrie & Gynaecologie 1992;105:4-6 BCJM Fauser,TD Pache, WCJ Hop, FH de Jong, KD Dahl. The significance of a single LH measurement in women with mentrual cycle disturbances:discrepancies between immunoreactive and bioreactive hormone estimates. Clinical Endocrinology (Oxf) 1992;37: TD Pache & TJ Cummings. Inclure l enseignement de l économie de la santé dans le curriculum des médecins. Une façon de contenir l augmentation des coûts? Schweizerische Medizin Wochenschrift 1992;122: TD Pache, FH de Jong, WCJ Hop, BCJM Fauser. Association between ovarian changes assessed by transvaginal sonography and clinical and endocrine signs of the polycystic ovary syndrome. Fertility and Sterility 1993;59: RFA Weber, TD Pache, ML Jacobs, R Docter, D Lynn Loriaux, BCJM Fauser, JC Birkenhäger. The relation between clinical manifestations of polycystic ovary syndrome and β-cell function. Clinical Endocrinology (Oxf) 1993;38: TD Pache, Y Vial, P de Grandi. La croissance folliculaire normale, monitorage par ultrasonographie endovaginale. La lettre du gynécologue 1993;184:52-54 PJF Donderwinkel, DC Schoot, TD Pache, FH de Jong, WCJ Hop, BCJM Fauser. Luteal function following ovulation induction in polycystic ovary syndrome patients using exogenous gonadotrophins in combination with a gonadotrophin-releasing hormone agonist. Human Reproduction 1993;8: AGP Schuller, DJ Lindenbergh-Kortleve, TD Pache, EC Zwarthoff, BCJM Fauser, SLS Drop. Insulin-like growth factor binding protein-2, 28 kda and 24 kda insulin-like growth factor binding protein levels are decreased in fluid of dominant follicles, obtained from normal and polycystic ovaries. Regulatory Peptides 1993;48: TD Pache & BCJM Fauser. Polycystic ovaries in female-to-male transsexuals. Clinical Endocrinology (Oxf) 1993;39:702-3 DC Schoot, WCJ Hop, TD Pache, FH de Jong, BCJM Fauser. Growth of dominant follicle in spontaneous cycles and gonadotropin-stimulated polycystic ovary syndrome patients. Acta Endocrinologica (Kbh) 1993;129:

6 S Chadha, TD Pache, FJM Huikeshoven, AO Brinkmann, ThH van der Kwast. Androgen receptor expression in human ovarian and uterine tissue of long term androgen-treated transsexual women. Human Pathology 1994;25: HJHM van Dessel, I Schipper, TD Pache, H van Geldorp, FH de Jong, BCJM Fauser. Normal human follicle development: a reevaluation of correlations with estradiol, androstenedione, and progesterone levels. Aldo Campana, Denny Sakkas, Anne Stalberg, Patrizia Grace bianchi, Isabelle Comte, TD Pache and Dilys Walker. Intrauterine insemination : evaluation of the results according to the women s age, sperm quality, total sperm count per insemination and life table analysis. Human Reproduction 1996; vol.11 no 4 pp F. Luzuy, TD Pache et A. Campana. Le Gynécologue face à l ostéoporose. Médecine & Hygiène 1997; 55 : D. Thiébaud, J.M. Bigler, S. Renteria, TD. Pache, H.J. Welti, M. Landry and P. Burckhardt. A 3-year study of prevention of post-menopausal bone loss : conjugated equine estrogens plus medroxyprogesterone acetate versus tibolone. Cimacteric 1998; 1 : D Thiébaud, JM Bigler, SC Renteria, TD Pache, HJ Welti, M Landry, P Burckhardt. Prevention of postmenopausal bone loss for three years: conjugated estrogen plus medroxyprogesterone versus tibolone. J. Menopause 1999; 1 : LIST OF PUBLICATIONS TEXTBOOK CHAPTERS & REVIEWS TD Pache. Intérêt de l échographie dans le diagnostic différentiel de l hydrops fetalis non immunologique. M.D. Thesis. University of Lausanne School of Medicine, Lausanne, Switzerland. 1989;1-65 TD Pache. Cours de Gynécologie - Elèves infirmières de l Ecole de Soins Infirmiers de Morges (ESIM), Morges, Switzerland. 1988; TD Pache. Echoscopie van normale follikelgroei. In : Echoscopie en voortplanting bij de vrouw. Eds. Post Academisch Ondermisch Geneeskunde en Gezondheids-wetenschappen (Postgraduate Course), Erasmus Universiteit, Rotterdam, The Netherlands. 1990;17-21 TD Pache, BCJM Fauser. Is bij het polycysteus ovarium syndroom (PCOS) de selectie van de dominante follikel gestoord? Annalen van de Nederlands-Belgische Vereniging voor Fertiliteitsstudie 1991;18(1):42-44 BCJM Fauser & TD Pache. Follicular development in polycystic ovary syndrome. In: Postgraduate Course in Reproductive Medicine. Stolte Seminar. Eds. Post Academisch Onderwijs Geneeskunde en Gezondheidswetenschappen, Vrije Universiteit, Amsterdam, The Netherlands. 1991; TD Pache & BCJM Fauser. Follicular maturation arrest in polycystic ovary syndrome. Endocrine and sonographic aspects. Experimental & Clinical Endocrinology 1991;10:1-6 ML Jacobs, JC Birkenhäger, RFA Weber, TD Pache, BCJM Fauser. Insulineresistentie en PCOS. Annalen van de Nederlands-Belgische Vereniging voor Fertiliteitsstudie 1991;18(2):29-31 TD Pache. Disturbed growth and selection of the human ovarian follicle. Ph.D. Thesis. Erasmus University, Rotterdam, The Netherlands. Pasmans Offsetddrukkerij, The Hague, The Netherlands. 1993;1-139 TD Pache. Significance of monitoring ovarian function using transvaginal sonography. In: Clinical Reproductive Endocrinology and Fertility, Eds. BCJM Fauser & JLH Evers. ESHRE Postgraduate Course No 2. The Hague, Holland, 1992;40-45 TD Pache. Cours de Gynécologie. Ecole Cantonale Vaudoise de Sage-femmes. Lausanne, Switzerland,1992;1-25 6

7 BCJM Fauser, TD Pache, WCJ Hop, FH de Jong, KD Dahl. The significance of a single LH measurement in women with menstrual cycle disturbances: discrepancies between immunoreactive and bioactive hormone estimates. Obstetrical & Gynecological Survey 1993;48: TD Pache. Evidence pour un rôle des androgènes dans l induction de la transformation polykystique des ovaires: le modèle transsexuel. Reproduction Humaine et Hormones 1993;6: RFA Weber, TD Pache, ML Jacobs, R Docter, D Lynn Loriaux, BCJM Fauser, JC Birkenhäger. The relation between clinical manifestations of polycystic ovary syndrome and β-cell function. Obstetrical & Gynecological Survey 1993;48: BCJM Fauser, TD Pache, DC Schoot. Dynamics of human follicle development. In: Hsueh AJW & Schomberg D Eds., Ovarian Cell Interactions; genes to physiology. Serono Symposia Series, Raven Press, New York, 1993; TD Pache. Contragestion post-coïtale, un nouveau mode de contraception par interception. Génésis 1994;2:19-21 A Campana & TD Pache. Aménorrhée. Cours d endocrinologie gynécologique, Facultés de Médecine des Universités de Genève et Lausanne. 1994;1-19 TD Pache. Ultrasound monitoring of ovarian function and ovarian stimulation. 4th Post-graduate Course for training in Reproductive Medicine and Reproductive Biology. WHO Collaborating Centre for Research in Human Reproduction - Clinic for Infertility and Gynecologic Endocrinology, University Hospital, Geneva, Switzerland. 1994;1-28 TD Pache & A Campana. The use of transvaginal sonography to diagnose polycystic ovaries and polycystic ovary syndrome. Ultrasonica 1994;2:31-40 BCJM Fauser & TD Pache. Polycystic ovary syndrome : normal and abnormal ovarian follicular development. In: Ovarian Endocrinopathies. Proceedings of the 8th Reinier de Graaf Symposium (1993), Amsterdam, The Netherlands. R Schats R & J Schoemaker Eds., Parthenon Publishing, London, United Kingdom, 1994; C Lelaidier & TD Pache. La dystocie des épaules: ménager les risques et éviter la négligence. Editorial. Génésis, 1994;4:1-3 TD Pache & A. Campana. Transvaginal Ultrasound in Family Planning. Part I: Ovarian Function and Dysfunction. Training Course on Reproductive Health Services and Research Workshop for Eastern Europe (WHO Special Progamme of Research Development and research Training in Human Reproduction). Uppsala, Sweden. 1994;1-9 TD Pache & M Dodson. Transvaginal Ultrasound in Family Planning. Part II: First Trimester Pregnancy - Ectopic Pregnancy - Gestational Trophoblastic Disease - IUDs localization - Endometriosis. Training Course on Reproductive Health Services and Research Workshop for Eastern Europe (WHO Special Programme of Research Development and Research Training in Human Reproduction). Uppsala, Sweden. 1994;1-16 M Dodson & TD Pache. Clinical uses. In : Melvin Dodson Ed., Transvaginal Ultrasound, 2nd edition. Churchill Livingstone, New-York, 1995;1-16 M Dodson & TD Pache. Basic principles and equipment. In: Melvin Dodson Ed., Transvaginal Ultrasound, 2nd edition. Churchill Livingstone, New-York, 1995;17-24 M Dodson & TD Pache. The pelvic ultrasound examination and pelvic anatomy. In: Melvin Dodson Ed., Transvaginal Ultrasound, 2nd edition. Churchill Livingstone, New-York, 1995;25-42 M Dodson & TD Pache. The uterus. In: Melvin Dodson Ed., Transvaginal Ultrasound, 2nd edition. Churchill Livingstone, New-York, 1995;51-71 TD Pache & A Campana. Le diagnostic précoce de la grossesse extra-utérine. Editorial. Génésis, 1994;8:1-3 7

8 TD Pache. Les aspects psychosociaux des troubles androgénétiques. Editorial. Génésis, 1995;10:1-2 TD Pache. Transvaginal ultrasound of the pelvis. Normal ovaries, What are they? Ultrasound International, 1995;1:56-59 TD Pache, BCJM Fauser, S. Chadha. Conséquences d une élévation de la testostérone sérique chez la femme transsexuelle. Génésis, 1995;13:21-23 TD Pache. L identité du genre, de la biologie à l orientation sexuelle. Editorial. Génésis, 1995;13:1-2 TD Pache & B. Pornel. Prévention des problèmes cardio-vasculaires à la ménopause: les facteurs de risque. Génésis, 1995;15:4-6 TD Pache. Transvaginal ultrasound of the pelvis. Polycystic ovaries, what are they? Ultrasound International, TD Pache & BCJM Fauser. Pelvic ultrasound and diagnosis of polycystic ovaries. European Journal of Radiology, LIST OF PUBLICATIONS- ABSTRACTS 1990 TD Pache, JW Wladimiroff, BCJM Fauser. Number and size of follicles available for selection of a preovulatory follicle in normal menstrual cycles. 7h Reinier de Graaf Symposium (Maastricht, The Netherlands), Abstract p 47 TD Pache. JW Wladimiroff, BCJM Fauser. In vivo evidence for the existence of paracrine regulatory mechanisms in the ovary. VII World Congress of Human Reproduction (Helsinki, Finland), Abstract BCJM Fauser, TD Pache, FH de Jong, KD Dahl. Serum immunoreactive and bioactive luteinizing hormone levels in woman with polycystic ovarian disease. 73rd Annual Meeting American Endocrine Society (Washington, DC, USA), Abstract 353 TD Pache, WCJ Hop, LJG Gooren, BCJM Fauser (SPON: R. Rolland). Intrafollicular estradiol and androstenedione levels in non-domiant follicles in normal and polycystic ovaries, and in ovaries from female to male transsexuals. 73rd Annual Meeting American Endocrine Society (Washington, DC, USA), Abstract 1168 TD Pache, BC Schoot, JW Wladimiroff, BCJM Fauser. Use of transvaginal sonography for the diagnosis of polycystic ovaries. 47th Annual Meeting American Fertility Society (Orlando, FA, USA), Abstract 73, S32 BC Schoot, TD Pache, WCJ Hop, FH de Jong, BCJM Fauser. Redistribution of small ovarian follicles in polycystic ovarian syndrome (PCOS), during treatment with gonadotropin releasing hormone analog (GnRH-A) and human menopausal gonadotropins (HMG) in a fixed versus decreasing dosage scheme. 47th Annual Meeting American Fertility Society (Orlando, FA, USA), Abstract 48, S21 BCJM Fauser, TD Pache, FH de Jong, K Dahl. Luteinizing hormone - follicle stimulating hormone ratios in women with cycle abnormalities, with or without polycystic ovarian disease. 47th Annual Meeting American Fertility Society (Orlando, FA, USA), Abstract 115, S BCJM Fauser, TD Pache, FH de Jong, KD Dahl. Validation of serum immunoreactive and bioactive luteinizing hormone estimates in women with cycle disturbances. 39th Annual Meeting of the Society for Gynecologic Investigation (San Antonio, TX, USA), Abstract 614 8

9 DC Schoot, TD Pache, WCJ Hop, FH de Jong, BCJM Fauser. Growth of the dominant follicle in spontaneous cycles and gonadotropin-stimulated polycystic ovary syndrome (PCOS) patients. Ixth International Congress of Endocrinology, Satellite symposium on gonadotropins, GnRH analogs and gonadal peptides (Paris, France), Abstract p 120 PFJ Donderwinkel, DC Schoot, WC hop, TD Pache, BCJM Fauser. Gonadotropin induction of ovulation and luteal function in polycystic ovary syndrome patients. Ixth International Congress of Endocrinology, Satellite symposium on gonadotropins, GnRH, GnRH analogs and gonadal peptides (Paris, France), Abstract p 122 TD Pache. Conséquences d une élévation de la testostérone. Utilisation d un modèle original: les transsexuels femme-homme. 20es Journées sur la fertilité et l orthogénie. (Paris, France), Abstract 1993 TD Pache. How to discriminate between normal and polycystic ovaries. A transvaginal ultrasound study. Clinical Digest Series. TD Pache. Gestoorde follikelgroei en selectie in het humane ovarium. Nederlands Tijdschrift voor Obstetrie & Gynaecologie TD Pache, BCJM Fauser, WCJ Hop. Total testosterone serum levels alone may predict ovarian polycystic changes. Dreiländertagung Fertilität und Sterilität. (Lugano, Switzerland), Abstract TD Pache, BCJM Fauser. Association entre les modifications de structure ovarienne déterminées par échographie transvaginale (TVS) et les signes cliniques et biochimiques du syndrome des ovaires polykystiques (SPCO). Assemblée annuelle de la Société Suisse de Gynécologie et Obstétrique. (Lugano, Switzerland), Abstract p 57 & Archives of Gynecology and Obstetrics 1993 (253), S153 Y Vial, EO Adjahoto, TD Pache, P de Grandi. Cornual pregnancy: nonsurgical treatment and transvaginal sonography follow-up. 2nd International Meeting of the European Society of Endosonography in Gynaecology and Obstetrics. (London, United Kingdom), Abstract 47 DC Schoot, TD Pache, WC Hop, FH de Jong, BCJM Fauser. Growth patterns of ovarian follicles during induction of ovulation with decreasing doses of human menopausal gonadotropin following presumed selection in polycystic ovary syndrome. Hormonescope TD Pache. Ultrasonography of the ovaries: evaluation of polyfollicular/multicystic reaction. In: Hyperandrogenemia: etiology, interactions, symptomatology, diagnostics, therapy. Campus Workshop of the European Society of Human Reproduction and Embryology, Annual Meeting 1994 Arbeitsgemeinschaft des Gynäkologischen Endokrinologie und Reproduktionsmedizin. (Freiburg i/brisgau, Germany), Abstract p 14 G Girardet, F Luzuy, Th Pache, A Campana. Contrôle de l épaisseur de l endomètre sous substitution hormonale oestroprogestative continue par échographie endovaginale. Assemblée annuelle de la Société Suisse de Gynécologie et Obstétrique. (Lausanne, Switzerland), Abstract p 42 & Archives of Gynecology and Obstetrics 1994 ( ), S M Germond, N Vargiu, JC Alexis, Th Pache, P de Grandi. Etude comparative des trois produits de contraste non ioniques dans l hystérosalpingographie: iopentol (imagopaque), iotrolan (Telebrix 38), ioxithalamate (Isovist 300). Assemblée annuelle de la Société Suisse de Gynécologie et Obstétrique. (Lausanne, Switzerland), Abstract p 55 & Archives of Gynecology and Obstetrics 1994 ( ), S SC Renteria, T Pache, HJ Welti, P de Grandi. Efficacy of treatment with ORG OD 14 (Livial R ) during the early climacterium: a comparative study. XIVè Congrès de la Fédération Interantionale de Gynécologie et Obstétrique (FIGO). (Montréal, Canada), Abstract p 9

10 1995 D Thiébaud, JM Bigler, Th Pache, HJ Welti, P Schnyder, P Burckardt. Prevention of postmenopausal bone loss: conjugated estrogen plus medroxyprogesterone versus tibolone. XII th International Conference on Calcium Regulating hormones. (Melbourne, Australia), Abstract p TD Pache. Monitorage échographique et hormonal de la stimulation ovarienne. Journée Romande d Endocrinologie Gynécologique. (Geneva, Switzerland), Abstract p 4-5 TD Pache. Place de l échographie dans l investigation de la stérilité. Cours de formation post-graduée pour les candidats au titre de FMH en gynécologie-obstétrique (fertilité-stérilité, endocrinologie et biologie de la reproduction). (Lausanne, CHUV, Switzerland). pp D Thiébaud, JM Bigler, TD Pache, HJ Welti, P Burckhardt. Three years prevention of postmenopausal bone loss : conjugated estrogen-medroxyprogesterone versus tibolone World Congress on Osteoporosis. (Amsterdam, The Netherlands), Abstract p LIST OF PUBLICATIONS - CONFERENCES 1990 Follicular growth in the normal menstrual cycle - morphology versus transvaginal sonography. Thema Refereeravond Afdeling Gynaecologie, Dijkzigt Ziekenhuis, Follikelgroei - basale en klinische aspecten. Rotterdam, The Netherlands. January the 23rd In vivo evidence for the existence of paracrine regulatory mechanisms in the ovary. VII World Congress of Human Reproduction. Helsinki, Finland. June the 27th Use of transvaginal sonography in the assesment of ovarian appearance in menstrual cycle disturbances. XI Infertiliteit Bespreking. Rotterdam, The Netherlands. October the 15th Echoscopie van follikelgroei. PAOG (Post graduate Medical Education) cursus - Echoscopie en Voortplanting bij de vrouw. Rotterdam, The Netherlands. November the 15th FSH Binding activity in human ovarian follicular fluid in polycystic ovarian disease. III Vergadering Nederlandse Gonadotropinen Dwarsverband. Oss, The Netherlands, November the 23rd 1991 Is bij het polycysteus ovarium syndroom de selectie van de dominante follikel gestoord? Voorjaarsvergadering van de Nederlands-Belgische Vereniging voor Fertiliteitsstudie. Amsterdam, The Netherlands. April the 27th Differences between normal and polystic ovaries. Transvaginal sonography and intra-ovarian follicular steroid content studies. Afdeling Gynaecologie en Verloskunde, Dijkzigt University Hospital. Rotterdam, The Netherlands, July the 24th Use of transvaginal sonography for the diagnosis of polycystic ovaries. 47th Annual Meeting American Fertility Society. Orlando, Florida, USA, October the 22nd 1992 Evidence pour un rôle des androgènes dans l induction de la transformation polykystique des ovaires. Séminaire de la Division d Endocrinologie et Biochimie Clinique, CHUV. Lausanne, Switzerland, February the 25th La contraception hormonale. Colloque de gynécologie pour les médecins de la ville et région de Sierre, Sierre, Switzerland, May the 21st 10

11 Significance of monitoring ovarian function using transvaginal sonography. 1st ESHRE Postgraduate Course in Clinical Reproductive Endocrinology and Fertility. 8th Annual Meeting of the European Society of Human Reproduction and Embryology. The Hague, the Netherlands, July the 5th Conséquences d une élévation de la testostérone. Utilisation d un modèle original: les transsexuels femmehomme. 20es Journées sur la Fertilité et l Orthogénie. Paris, France, November the 8th 1993 Disturbed growth and selection of the human ovarian follicle. Ph.D. maintainig Erasmus University, Rotterdam, The Netherlands, January the 6th Perturbation des mécanismes de sélection folliculaire et transformation polykystique des ovaires. Concept et implications. Séminaire de l Unité de Stérilité et Biologie de la Reproduction, Département de Gynécologie et Obstétrique, Lausanne-CHUV, Switzerland, January the 11th Association entre les modifications de structure ovarienne déterminées par échographie transvaginale et les signes cliniques et biochimiques du syndrome des ovaires polykystiques. Assemblée annuelle de la Société Suisse de Gynécologie et Obstétrique, Lugano, Switzerland, June the 25th 1994 Ultrasonography of the ovaries: evaluation of polyfollicular/multicystic reaction. Campus Workshop of the European Society of Human Reproduction and Embryology (ESHRE) and Annual Meeting 1994 Arbeitsgemeinschaft der Gynäkologischen Endokrinologie und Reproduktionsmedizin (AGGER), Freiburg in Brisgau, Germany, March the 26th Hyperandrogénie d origine ovarienne. Séminaire de la Clinique de Stérilité et Endocrinologie Gynécologique, Hôpital Cantonal Universitaire de Genève, Geneva, Switzerland, April the 18th Ovaires polykystiques chez la femme transsexuelle après traitement aux androgènes. Cours de Formation Postgraduée et Continue de la Société Suisse d Endocrinologie, Münchenwiller, Switzerland, April the 29th Aspects nutritionnels et hormonaux de l ostéoporose. FORUM, Radio Suisse Romande, Lausanne, Switzerland, May the 9th Ultrasound monitoring of ovarian function. 4th Post-graduate Course for training in Reproductive Medicine and Reproductive Biology. WHO Collaborating Centre for Research in Human Reproduction - Clinic for Infertility and Gynecologic Endocrinology, University Hospital, Geneva, Switzerland, September the 27th Monitoring of ovarian stimulation. 4th Post-graduate Course for training in Reproductive Medicine and Reproductive Biology. WHO Collaborating Centre for Research in Human Reproduction - Clinic for Infertility and Gynecologic Endocrinology, University Hospital, Geneva, Switzerland. September the 27th Transvaginal Ultrasound Examination in Family Planning. Training Course on Reproductive Health Services and Research Workshop for Eastern Europe (WHO Special Programme of Research Development and Research Training in Human Reproduction). Uppsala University, Uppsala, Sweden, November the 9th 1995 Hirsutisme - Hyperandrogénie. Démarche diagnostique. Policlinique de Dermatologie et de vénéréologie, Hôpital Cantonal Universitaire, Geneva, Switzerland, Februara the 2nd Monitorage échographique et hormonal de la stimulation ovarienne. Journée Romande D Endocrinologie Gynécologique. Hôpital Cantonal Universitaire, Geneva, March the 16th About the role of androgens in the polycystic transformation of the ovaries. Department of gynecology and Obstetrics, University of Saskatchewan, Saskatoon, Canada, May the 20th 11

12 Indications et limites de l hystérosonographie avec produit de contraste (Echovist R ). Hôtel du Lac, Morges, Switzerland, May the 23rd & September the 11th. Choully (Geneva), October the 12th. Steps in writing a scientific paper. 5th Post-graduate Course for training in Reproductive Medicine and Reproductive Biology. WHO Collaborating Centre for Research in Human Reproduction - Clinic for Infertility and Gynecologic Endocrinology, University Hospital, Geneva, Switzerland. September the 14th Approche diagnostique et possibilités de traitement lors de la ménopause. Colloque mensuel de la Clinique la Prairie, Clarens/Montreux, September the 12th Il sindrome dell ovaio policistico: dati clinici e biochimici, approccio transvaginale per l esame ecografico, e ipotesi sulla patogenesi del sindrome. Clinic for Gynecology, University of Tirana School of Medicine, Tirana, Albania, September the19th Monitoring of ovarian stimulation. 5th Post-graduate Course for training in Reproductive Medicine and Reproductive Biology. WHO Collaborating Centre for Research in Human Reproduction - Clinic for Infertility and Gynecologic Endocrinology, University Hospital, Geneva, Switzerland. September the 28th European Menopause Centers: a concept to face a human and health care problem. Milano, Italy, October the 12th Imagerie en Infertilité. Ultrasonographie du cycle menstruel. Séminaire de la Clinique de Stérilité et Endocrinologie Gynécologique, Hôpital Cantonal Universitaire de Genève, Geneva, Switzerland, October the 16th Place de l échographie dans l investigation de la stérilité. Cours de formation post-graduée pour les candidats au titre de FMH en gynécologie-obstétrique (fertilité-stérilité, endocrinologie et biologie de la reproduction). Département de Gynécologie et Obstétrique, Lausanne, CHUV, Switzerland. November the 4th The Menopause. Facts, myths, and reality. American Women Association. Hôtel Mövenpick Radisson, Lausanne, Switzerland, November the 7th 1996 Place de l échographie en infertilité. Colloques hebdomadaires du Service de Gynécologie et Obstétrique. Hôpital de la Chaux-de-Fonds Several talks in the field of menopause for general physicians and gynacecologists 2001 Clinique La Prairie-Clarens/Montreux Round : «Nouveau concept en chirurgie gynécologique» Clinique La Prairie-Clarens/Montreux Round : «Substitution hormonale, le point sur la question» Menopause & andropause. Kiwanis Club Meeting, Gruyères, Switzerland : Clinique La Prairie-Clarens/Montreux Round: «Génomique et vieillissement»

13 Menopause et hormones dans un monde nouveau. Controverses et orientations. At large public information talk, Vevey, Switzerland, October the 7th. Menopause & hormones & médecine prédictive. Blonay, Switzerland, Unilabs Talks, November the 11th 2004 to 2012 Several talks in the field of better ageing and menopause La Ménopause Primum non nocere. Colloque de formation post-grade, collectif médecins lausannois, Chexbres, Switzerland, January the 30th LIST OF PUBLICATIONS - POSTERS - SEMINARS - MISCELLEANOUS TD Pache. Intérêt de l échographie dans le diagnostic différentiel de l hydrops fetalis non immunologique. Mémoire. Certificat d Université d Echographie Gynécologique et Obstétricale. Université Louis Pasteur de Strasbourg, Strasbourg, France. 1988;1-43 TD Pache, JW Wladimiroff, WCH Hop, BCJM Fauser. Number and size of follicles available for selection of a pre-ovulatory follicle in normal menstrual cycles. POSTER. 7th Reinier de Graaf Symposium (Maastricht, The Netherlands). May 30th to June 2nd of 1990 TD Pache & WJ de Greef. Cyclusstornissen Workshop 15de Nascholingscursus Endocrinologie. Nordwijkerhout, The Netherlands. November the 28th of 1990 BCJM Fauser, TD Pache, FH de Jong, KD Dahl. Serum immunoreactive and bioactive luteinizing hormone levels in women with polycystic ovarian disease. POSTER. 73rd Annual Meeting American Endocrine Society. Washington DC, USA, June the 19th of 1991 TD Pache, WCJ Hop, LJG Gooren, BCJM Fauser, R. Rolland. Intrafollicular estradiol and androstenedione levels in non-dominant follicles in normal and polycystic ovaries, and in ovaries from female to male transsexuals. POSTER. 73rd Annual Meeting American Endocrine Society. Washington DC, USA, June the 21st of 1991 BCJM Fauser, TD Pache, FH de Jong, KD Dahl. Validation of serum immunoreactive and bioactive luteinizing hormone estimates in women with cycle disturbances. POSTER. 39th Annual Meeting of the Society for Gynecologic Investigation. San Antonio, Texas, USA, March, March the 19th of 1992 TD Pache, BCJM Fauser, WCJ Hop. Total testosterone serum levels alone may predict ovarian polycystic changes. POSTER. Dreiländertagung Fertilität und Sterilität. Lugano, Switzerland, May 4th to 6th of 1993 Y Vial, EO Adjahoto, TD Pache, P de Grandi. Cornual Pregancy: nonsurgical treatment and transvaginal sonography follow-up. POSTER. 2nd International Meeting of the European Society of Endosonography in Gynaecology and Obstetrics. London, United Kingdom, July the 7th to the 9th of 1993 H Hellema, TD Pache. Interview: PCOS gevolg van intra-ovariële stoornis bij follikel-selectie. Tijdschrift voor Ferttiliteitsonderzoek 1993;2:36-38 TD Pache. Question-answering Session on ultrasound monitoring of ovulation and tracking of ovarian stimulation. 4th Post-graduate Course for training in Reproductive Medicine and Reproductive Biology. WHO collaborating Centre for Research in Human Reproduction - Clinic for Infertility and Gynecologic Endocrinology, University Hospital, Geneva, Switzerland. September the 27th of 1994 M Horga, TD Pache, V Odlind, S Alexaniants. Seminar on Improving Acceptability of Contraception. Training Course on Reproductive Health Services and Research Workshop for Eastern Europe (WHO Special Programme 13

14 of Research Development and Research Training in Human Reproduction). Uppsala, Sweden, November the 7th of 1994 V Odlind, TD Pache, M Horga, S Alexaniants, T Pschenichnikova. Seminar on Contraception to Women with Medical Problems. Training Course on Reproductive Health Services and Research Workshop for Eastern Europe (WHO Special Programme of Research Development and Research Training in Human Reproduction). Uppsala, Sweden, November the 8th of 1994 A Campana, TD Pache. Collaboration entre la Clinique de Stérilité et d Endocrinologie Gynécologique et le Programme Spécial de l OMS pour la Recherche en Reproduction Humaine. Assemblée annuelle de la Société Suisse de Gynécologie et Obstétrique (Davos, Switzerland) TD Pache. I. Monitoring of ovarian stimulation. 5th Post-graduate Course for training in Reproductive Medicine and Reproductive Biology. WHO Collaborating Centre for Research in Human Reproduction - Clinic for Infertility and Gynecologic Endocrinology, University Hospital, Geneva, Switzerland. 1995;1-30 TD Pache. II. Monitoring of ovarian stimulation. Combined ultrasound and hormonal monitoring. 5th Postgraduate Course for training in Reproductive Medicine and Reproductive Biology. WHO Collaborating Centre for Research in Human Reproduction - Clinic for Infertility and Gynecologic Endocrinology, University Hospital, Geneva, Switzerland. 1995;1-11 TD Pache. Place de l échographie dans l investigation de la stérilité. Cours de formation post-graduée pour les candidats au titre de FMH en gynécologie-obstétrique (fertilité-stérilité, endocrinologie et biologie de la reproduction). Département de Gynécologie et Obstétrique, Lausanne, CHUV, Switzerland. 1995;

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