Curriculum vitae. Thesis title: Three-dimensional morphologic reconstruction and fluid-dynamic analysis of vascular capillary structures

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1 Curriculum vitae Personal information Last/First Name Antiga Luca Work address Villa Camozzi, Ranica (BG), Italy Telephone Homepage Nationality Italian Date of birth Oct 03, 1975 Gender M Mother tongue Italian Other languages English Fluent Expertise Medical and microscopy image analysis; Computational geometry; Mathematical modeling of transport phenomena; Computational fluid dynamics Education Dates Jan 2000 Jan 2003 Title awarded Subject PhD Thesis title: Patient-specific modeling of geometry and blood flow in large arteries Bioengineering Department, Politecnico di Milano Work carried out at the Bioengineering Department, Mario Negri Institute for Pharmacological Research Tutor: A. Remuzzi Dates Sep 1994 Dec 1999 Title awarded Subject MSc Thesis title: Three-dimensional morphologic reconstruction and fluid-dynamic analysis of vascular capillary structures Bioengineering Department, Politecnico di Milano Work carried out at the Bioengineering Department, Mario Negri Institute for Pharmacological Research Tutor: A. Remuzzi Work experience Dates Position Department Feb 2006 Onwards Head of the Medical Imaging Unit Bioengineering Department Mario Negri Institute for Pharmacological Research, Bergamo, Italy

2 Dates Apr 2004 Jan 2006 Position Full time researcher Department Bioengineering Department Mario Negri Institute for Pharmacological Research, Bergamo, Italy Dates Dec 2002 Dec 2003 Position Post-Doctoral Fellow Department Imaging Research Laboratories P.I.: D.A. Steinman Robarts Research Institute, London, Ontario, Canada Tutorship Student name Degree Botti Lorenzo PhD (in course) Mechanical Engineering, Bergamo University, 2006 Marina Piccinelli PhD (in course) Maastricht University Botti Lorenzo MSc Mechanical Engineering, Bergamo University, 2006 Pierantoni Gabriele MSc Mechanical Engineering, Bergamo University, 2005 Muzzi Roberto MSc Biomedical Engineering, Politecnico di Milano, 2005 Remuzzi Carlos BSc Biomedical Engineering, Politecnico di Milano, 2005 Ambrosini Emilia BSc Biomedical Engineering, Politecnico di Milano, 2005 Main collaborations David Steinman PhD, Biomedical Simulation Lab, University of Toronto National Alliance for Medical Image Computing (NA-MIC) Ron Kikinis MD, Surgical Planning Lab, Harvard Medical School Alessandro Veneziani PhD, Department of Mathematics & Computer Science, Emory University Radiology Department, Ospedali Riuniti di Bergamo, Bergamo, Italy Roberto Foroni, Neurology Unit, Ospedale Maggiore Borgo Trento, Verona, Italy Contribution to open source projects Project name Homepage Role Vascular modeling toolkit vmtk.sourceforge.net Lead developer Slicer 3 Contributor Plug-in developer Insight toolkit Contributor

3 Peer-Review activity Scientific journals IEEE Transactions on Medical Imaging 12 IEEE Transactions on Biomedical Engineering 1 Kidney International 2 Magnetic Resonance in Medicine 1 Journal of Vascular Research 1 Clinical Journal of the Americal Society of Nephrology 1 Journal of Biomechanics 2 Medical & Biological Engineering & Computing 1 Medical Engineering & Physics 1 Medical Physics 1 Conferences MICCAI 2007 Grants NSERC National Science and Engineering Research Counsil of Canada United States Israel Binational Science Foundation Publications Journal papers: Lee SW, Antiga L, Spence JD and Steinman DA. Geometry of the carotid bifurcation predicts its exposure to disturbed flow. Stroke, Accepted, Luciani D, Cavuto S, Antiga L, Miniati M, Monti S, Pistolesi M, Bertolini G. Bayes pulmonary embolism assisted diagnosis: a new expert system for clinical use. Emergency Medicine Journal (EMJ), 24: , Mar Antiga L, Piccinelli M, Fasolini G, Ene-Iordache B, Ondei P, Ruggenenti P, Remuzzi G and Remuzzi A. Computed tomography evaluation of ADPKD progression: a progress report. Clinical Journal of the American Society of Nephrology (CJASN), 1(4), Jul Moyle KR, Antiga L and Steinman DA. Inlet conditions for image-based CFD models: is it reasonable to assume fully-developed flow? Journal of Biomechanical Engineering, 128(3), Jun Thomas JB, Antiga L, Che S, Milner JS, Hangan Steinman DA, Spence JD, Rutt BK and Steinman DA. Variation in the carotid bifurcation geometry of young vs. older adults: Implications for "geometric risk" of atherosclerosis. Stroke, 36(11), Nov Ruggenenti P, Remuzzi A, Ondei P, Fasolini G, Antiga L, Ene-Iordache B, Remuzzi G and Epstein FH. Safety and efficacy of long-acting somatostatin treatment in autosomal dominant polycystic kidney disease. Kidney International, 68(1), Jul Antiga L, Steinman DA. Robust and objective decomposition and mapping of bifurcating vessels. IEEE Transactions on Medical Imaging, 23(6), June Antiga L, Ene-Iordache B and Remuzzi A. Computational geometry for patient-specific reconstruction and meshing of blood vessels from MR and CT angiography. IEEE Transactions on Medical Imaging, 22(5), May 2003.

4 Ene-Iordache B, Mosconi L, Antiga L, Bruno S, Anghileri A, Remuzzi G and Remuzzi A. Radial artery remodeling in response to shear stress increase within arteriovenous fistula for hemodialysis access. Endothelium, 10(2): , Remuzzi A, Ene-Iordache B, Mosconi L, Bruno S, Anghileri A, Antiga L and Remuzzi G. Radial artery wall shear stress evaluation in patients with arteriovenous fistula for hemodialysis access. Biorehology, 1-3: , Antiga L, Ene-Iordache B, Caverni L, Cornalba GP and Remuzzi A. Geometric reconstruction for computational mesh generation of arterial bifurcations from CT angiography. Computerized Medical Imaging and Graphics, 26(4): , June Antiga L, Ene-Iordache B, Remuzzi G and Remuzzi A. Automatic generation of glomerular capillary topological organization. Microvascular Research, 62: , June Book chapters: Antiga L, Peiró J, Steinman D. From image data to computational domain. In Quarteroni A, Formaggia L, Veneziani A (eds). Cardiovascular Mathematics, Springer NY Open access papers: Antiga L Generalizing vesselness with respect to dimensionality and shape. The Insight Journal, 2007 July- December issue, URI:http://hdl.handle.net/1926/576 (DSpace handle) Conference papers: Botti L, Piccinelli M, Ene-Iordache B, Remuzzi A, Antiga L. A open source parallel AMR FE solver for biological flows based on the libmesh C++ library. 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, July Piccinelli M, Botti L, Ene-Iordache B, Remuzzi A, Veneziani A, Antiga L. Link between vortex structures and Voronoi diagram in cerebral aneurysms. 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, July Antiga L. Bridging the gap between shape and flow. Fifth International Bio-Fluid Symposium and Workshop, Caltech, Pasadena, CA, March Antiga L, Steinman DA. Efficient MRI simulation via integration of the signal equation over triangulated surfaces. ISMRM 2008, International Society of Magnetic Resonance in Medicine, Toronto, Canada, May Forzenigo LV, Domanin M, Veneziani A, Gabrielli L, Vergara C, Biondetti PR, Foresti D, Molinari A, Antiga L, Piccinelli M. Using engineering mathematical models and CT 4D imaging to understand the hemodynamics after aortic prosthesis insertion. ECR 2008, European Congress of Radiology, Vienna, Austria, March Van Canneyt K, Kaminsky R, Antiga L, Tordoir J, Verdonck P, Eloot S. Experimental study of patient-specific kink in arterio-venous graft using particle image velocimetry. ESAO, European Society for Artificial Organs, Krems, Austria, September Lee SW, Antiga L, Steinman DA. Variation in the hemodynamics of young adult carotid bifurcations. ASME Summer Bioengineering Conference, Keystone, CO, June Antiga L, Piccinelli M, Ene-Iordache B, Botti L, Remuzzi A, Boccardi E, Bacigaluppi S, Veneziani A. Hemodynamics and cerebral aneurysms: the role of geometry. 3rd International Symposium on Modelling of Physiological Fluids, Ranica (BG), Italy, September 2006 (invited). Antiga L, Planken N, Piccinelli M, Ene-Iordache B, Tordoir J, Remuzzi A. Flow instability in a failed brachiocephalic graft for hemodialysis: a computational study. 5th World Congress of Biomechanics, Munich, Germany, July-August 2006 (invited). Antiga L, Planken N, Piccinelli M, Ene-Iordache B, Huberts W, Remuzzi A, Tordoir J. Geometric intra-subject variability of arm vessels assessed by MRA: a challenge for quantification and modeling of the vascular access for hemodialysis. 5th World Congress of Biomechanics, Munich, Germany, July-August 2006.

5 Piccinelli M, Boccardi E, Bacigaluppi S, Veneziani A, Ene-Iordache B, Remuzzi A, Antiga L. Computational geometric analysis of cerebral aneurysms and their parent vasculature from CRA. 5th World Congress of Biomechanics, Munich, Germany, July-August Piccinelli M, Boccardi E, Bacigaluppi S, Veneziani A, Ene-Iordache B, Remuzzi A, Antiga L. Influence of siphon bends on the flow patterns of the internal carotid artery: implications for the study of aneurysm development. 5th World Congress of Biomechanics, Munich, Germany, July-August Veneziani A, Boccardi E, Antiga L, Secchi P, Vantini S, Passerini T, De Luca M, Bacigaluppi S. Statistical and numerical investigations of cerebral aneurysms' morphology and haemodynamics. 5th World Congress of Biomechanics, Munich, Germany, July-August Simedrea P, Antiga L, Steinman DA. Numerical simulation of MRI using unstructured grids. ISMRM 14th Scientific Meeting, Seattle, Washington, USA, May Simedrea P, Antiga L, Steinman DA. Towards a new framework for simulating magnetic resonance imaging. CSCBC 2006, Kingston, Ontario, Canada, March Ene-Iordache B, Antiga L, Fasolini G, Bruno S, Remuzzi G and Remuzzi A. Evaluation of renal morphology and its functional implications in autosomal dominant polycystic kidney disease. ASN 38th Annual Meeting and Scientific Exposition, Philadelphia, November Antiga L, Simedrea P, Steinman DA. On the overestimation of early intimal thickening at the carotid bulb via axial black blood MRI. 17th Annual International Workshop On Magnetic Resonance Angiography, Beijing, China, September Moyle KR, Antiga L, Steinman DA. Inlet conditions in hemodynamics - Effects of Secondary Flow on Modeled Wall Shear Stress at the Carotid Bifurcation. ASME Bioengineering Conference, Vail, Colorado, June Antiga L. Imaging and numerical fluid dynamics for the study of the cardiovascular system. Bioflumen III, November 15, 2004, Istituto Superiore di Sanita', Roma. Steinman DA, Antiga L. Effect of slice resolution and orientation on 3D reconstruction of artery wall thickness. 16th Annual International Workshop On Magnetic Resonance Angiography, London, Ontario, Canada, October Ene-Iordache B, Antiga L, Soletti L, Caverni L, Remuzzi A. Validation of a 3D reconstruction method for carotid bifurcation models starting from angio CT images. 6th International Symposium on Computer Methods in Biomechanics & Biomedical Engineering, Madrid, Spain, February Antiga L, Steinman DA. Automated parameterization and patching of bifurcating vessels. International Symposium on Modelling of Physiological Flows, Lausanne, Switzerland, September Thomas JB, Che SL, Milner JS, Antiga L, Rutt BK, Spence JD, Steinman DA. Geometric characterization of the normal and mildly diseased human carotid bifurcation.asme Bioengineering Conference, Key Biscayne, FL, June Antiga L, Ene-Iordache B and Remuzzi A. Centerline computation and geometric analysis of branching tubular surfaces with application to blood vessel modeling.11-th International Conference in Central Europe on Computer Graphics, Visualization and Computer Vision'2003, Plzen, Czech Republic, February Antiga L. Blood flow simulation in arterial bifurcations reconstructed from CT and MR angiography: GAMBIT, FIDAP and VTK integration. Fluent User Group Meeting, October , Maranello (MO), Italy. Antiga L. Geometria computazionale per la ricostruzione 3D e l'analisi geometrica patient-specific di segmenti vascolari da angiografia CT e MR. MOX, Politecnico di Milano, May Antiga L, Ene-Iordache B, Caverni L, Cornalba GP and Remuzzi A. Generazione di una metodica semiautomatica per la ricostruzione tridimensionale e l'analisi fluidodinamica di segmenti arteriosi mediante angio TC multistrato ed angio RM: teoria e fattibilità. Congresso Nazionale della Società Italiana di Radiologia Medica, Rimini, May Antiga L. Patient-specific models for blood flow in large arteries. Cardiovascular System: from Mathematical Modelling to Clinical Applications. MOX, Politecnico di Milano, March Antiga L, Ene-Iordache B, Remuzzi G and Remuzzi A. Automatic generation of glomerular capillary topological organization from serial section analysis. Cardiovascular System: from Mathematical Modelling to Clinical

6 Applications, MOX, Politecnico di Milano, March Antiga L. Tecniche di ricostruzione tridimensionale ed analisi fluidodinamica di vasi arteriosi. Quinto Workshop sul Calcolo ad Alte Prestazioni in Italia, CILEA, October , Università Cattolica del Sacro Cuore, Milano. Antiga L, Ene-Iordache B, Remuzzi G and Remuzzi A. Automatic generation of glomerular capillary topological organization from serial section analysis. 33rd Annual Meeting of the American Society of Nephrology, Toronto, Canada, Oct

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