Siemens Computed Tomography

An Innovation Leader in Technical and Clinical Solutions First CT from a med. manufacturer To produce cross sectional images First spiral CT scanner To leave the axial world First cardiac CT scanner To explore the heart First 0 MHU X-ray with TubeGuard (proactive tube failure prediction) since 2008 To scan without compromise First 64-slice CT scanner To routinely scan sub-mm resolution First Dual Source CT To alleviate compromise 1974 1987 1999 2003 2003 2005 First routine Dual Energy scan To change the face of CT First Adaptive Scanner 2006 2007 To adapt to any clinical need First Flash speed, lowest dose CT To make CT healthier 2008 First multimodality 3D imaging network To make reading fast & reproducible First patientcentric productivity FAST CARE for all Patients Page 2 October 2012 Waltraud Winter 2009 2010 First raw-data based Iter. Recon* To save up to 60% dose * The information about this product is being provided for planning purposes.the product is pending 510(k) review, and is not yet commercially available in the U.S. Data on file. In clinicial practice, the use of SAFIRE may reduce CT patient dose depending on the clinical task, patient size, anatomical location, and clinical practice. A consultation with a radiologist and a physicist should be made to determine the appropriate dose to obtain diagnostic image quality for the particular clinical task. Dose reduction potential was determined by lowering dose by 60% and reconstructing with SAFIRE. Noise, CT numbers, homogenity, low-contrast resolution and high-contrast resolution were assessed in Gammex 438 phantom. Low dose data reconstructed with SAFIRE showed the same image quality compared to full dose data based on this test. Data on file. 2010

An Innovation Leader in Low Dose Computed Tomography Up to 68% Up to 30% Up to 70% Up to 50% Up to 50% CARE Dose4D 1994 1997 Ultra Fast Ceramic (UFC) Hand CARE Siemens Pediatric 1999 Exclusive 2002 80 kv Protocols DSCT 2005 Siemens Exclusive 1-3 msv Adaptive ECG- Pulsing/Sequence 2007 X-ray low Up to 25% < 1 msv No penalty Up to 40% Up to 60% Up to 60% Adaptive Dose Shield 2007 Flash Spiral 2008 Siemens Exclusive Selective Photon Shield Siemens X-CARE 2008 Exclusive 2008 Siemens Exclusive compared Page to full 3dose data based on this test. Data October on file. 2012 Waltraud Winter IRIS 2009 SAFIRE* 2010 Siemens Exclusive *In clinical practice, the use of IRIS and SAFIRE may reduce CT patient dose depending on the clinical task, patient size, anatomical location, and clinical practice. A consultation with a radiologist and a physicist should be made to determine the appropriate dose to obtain diagnostic image quality for the particular clinical task. ** Dose reduction potential was determined by lowering dose by 60% and reconstructing with IRIS. Noise, CT numbers, homogenity, low-contrast resolution and high contrast resolution were assessed in a Gammex 438 phantom. Low dose data reconstructed with IRIS showed the same image quality *** The information about this product is being provided for planning purposes.the product is pending 510(k) review, and is not yet commercially available in the U.S.Dose reduction potential was determined by lowering dose by 60% and reconstructing with SAFIRE. Noise, CT numbers, homogenity, low-

Siemens CT Product Portfolio CT Oncology syngo.via* CT Cardio-Vascular CT Neuro Engine Engine CT Acute Care Engine Engine SOMATOM FAST CARE Technology Spirit Emotion Emotion Excel Definition AS Definition AS Excel Definition AS+ Definition AS+ Excel Definition Flash * syngo.via can be used as a standalone device or together with a variety of syngo.via based software options, which are medical devices in their own rights. Page 4 October 2012 Waltraud Winter

Evolution of Dual Source CT 2005 2008 2010 2011 1. Generation DSCT SOMATOM Definition 2. Generation DSCT SOMATOM Definition Flash FAST CARE Platform Stellar Detector Faster Then Every Beating Heart Flash Speed. Lowest Dose. Leverage untapped potential in patient-centric productivity First fully integrated Detector Experience of 500 DSCT's Experience of > 400 DSCT's Experience of > 500 installations UFC experience of >14 years DSCT: Dual Source CT UFC: Page Ultra 5Fast Ceramics October 2012 Waltraud Winter

Siemens CT in Numbers The number 1 CT provider in the world * A leader in product innovations More than 2.000 new CT systems per year Installed base worldwide: > 16.400 systems 3.550 employees worldwide, 715 in Forchheim, 330 in Shanghai *Based on market share worldwide in FY09/10 Page 6 October 2012 Waltraud Winter

Medical Progress Source: www.kkg.ch Source: Schaumburger Zeitung Source: www.kkg.ch Source: www.reohr.com Page 7 October 2012 Waltraud Winter

Documentation Progress Page 8 October 2012 Waltraud Winter

Different User Behavior Page 9 October 2012 Waltraud Winter

The User Searches for Information Page 10 October 2012 Waltraud Winter

Delivering Topics to the Customer Via a Portal Functional modules Publish On-Demand Portal KG Social Collaboration Intelligent Search Content Management System Web portal that provides users with a flexible interface to achieve their goals Search engine for easy retrieval of needed information in the right granularity Collaboration platform to connect customers and facilitate collaborative working Publishing module to provide information in multiple formats for various devices Interfaces from/to external systems Page 11 October 2012 Waltraud Winter

Connect to the Portal Through Any Computer Page 12 October 2012 Waltraud Winter

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Calcium Scoring Physical Background Page 20 October 2012 Waltraud Winter

Topics as the Best Basis Topic Topic Topic Topic Topic Topic Topic Topic Topic Topic Topic Topic Topic Topic Topic Topic Installation Guide Maintenance Guide Troubleshooting Whatever needed Page 21 October 2012 Waltraud Winter

Topic Requirements Right Size and Right Data Right size Right metadata Page 22 October 2012 Waltraud Winter

Comfortable and Easy Way of Using the Portal Semantic Search Facetted Search Results By integrating background knowledge (synonyms, taxonomies, etc.) Dynamic categorization of search results Context-Sensitive Search Knowledge Gateway Portal Query Completion realized by a context & user model realized by a Type-Ahead-Search functionality Knowledge Gateway Portal Page 23 October 2012 Waltraud Winter Source: Skubacz/Zillner, Corp. Technology

Main Modules of The Portal Information Architecture (for portal and CMS) Structural design of documentation information Modularization and organization of documentation to support content composition Establish a meta-model for flexible characterization Creating a semantic relationships model to capturing knowledge interaction UserWorkflows DocSetA DocSet A Compilation Unit Group Unit Group Unit Compilation Unit Group Unit Compilation Unit Context Processing (portal) Modeling, Detecting and Processing of Search / Information Context Providing an Abstracting Layer that allows to determine the content relevance Means for the context-sensitive composition Approaches to smooth general-to-detail content representation Capturing and modeling of user documentation workflows Modeling Sof user roles and expectations Experimental verification of approaches Page 24 October 2012 Waltraud Winter Source: Skubacz/Zillner, Corp. Technology

The Cosmopolitan Topic From Creation to Delivery Sharing Information with One Look & Feel Portal CMS Publication on demand Knowledge@Siemens Knowledge@Customer One common CMS and One face to the customer: Knowledge Gateway Page 25 October 2012 Waltraud Winter

Siemens Computed Tomography Answers for Life. Copyright Siemens AG 2011. All rights reserved. Page 26 October 2012 Waltraud Winter International Version - not yet approved for H external IM CR distribution R&D SW in the CD U.S.

Professional software for simple creation of good technical documentation The Cosmopolitan Information Topic tc-world 2012 Wiesbaden Uwe Reißenweber Page 27 October 2012 Waltraud Winter

Professional software for simple creation of good technical documentation Page 28 October 2012 Waltraud Winter 28

Information Structuring Information Objects Annotations Ontologies Text Push Message Typ Tooltip FMA (Human Anatomy) Textfragments Images User-edit Content 1. Level Tooltip 2.Level Tooltip 3.Level Tooltip Error Message short medium detailed Examination Description Emergency Workflow-step 1 Workflow-step 2 Workflow-step 3 RadLex (Radiology Terminology) Context Model Product Catalogue and others Source: Page 29 October 2012 Waltraud Winter

Technical Requirements to the CMS Strong module (topic) management capabilities Strong and flexible classification features Open and flexible interfaces Page 30 October 2012 Waltraud Winter 30

Technical Requirements to the CMS Versioning (FDA Requirement) Traceability (FDA Requirement) Workflow support (FDA Requirement) Page 31 October 2012 Waltraud Winter 31

Technical Requirements to the CMS Comfortable integrated work environment Page 32 October 2012 Waltraud Winter 32

Technical Requirements to the CMS Strong translation management (>27 languages!) Page 33 October 2012 Waltraud Winter 33

Technical Requirements to the CMS World wide availability Scalability Robustness Page 34 October 2012 Waltraud Winter 34

COSIMA enterprise CMS After an intensive market survey and evaluation phase Siemens Healthcare chose COSIMA enterprise as their global CMS for the new topic oriented documentation strategy. Page 35 October 2012 Waltraud Winter 35

Thank you for your interest Page 36 October 2012 Waltraud Winter 36