July 22, 2015 XXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXX. Dear XXXXXXXX:

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July 22, 2015 XXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXX Dear XXXXXXXX: We, the undersigned 167 organizations, are writing on behalf of approximately 2.1 million researchers, members, and employees to bring to your attention the important role airline transportation plays in ensuring laboratory animals are available for lifesaving biomedical research and to request you revisit your company s policy regarding the shipment of non human primates for research purposes. Your company s commitment to transporting laboratory animals is crucial to finding treatments and cures for diseases afflicting millions of people worldwide. We ask that you continue transporting research animals allowing lifesaving research around the world to continue. The air transportation of animals for medical research is not new. Animals have been transported by air since the early 1930's. Unfortunately, due to perceived pressure from animal rights extremists seeking to end the use of all animals in biomedical research, some airlines claim they no longer accept shipments of animal models for research. We believe this decision is misguided and may have catastrophic consequences to health worldwide for both humans and animals. However, some airlines have taken the opposite approach and have publicly stated their support for facilitating ongoing medical research. Air France, for example, recently reaffirmed its commitment to shipping laboratory animals for lifesaving research by publishing a pro research statement on its website (see attachment). We respectfully request your airline review its policies regarding shipment of animal models and consider publishing a similar statement. Scientific and medical research with animals, whether transgenic mice or non human primates, is essential to the development of medications, treatments, preventions and cures for diseases affecting adults, children and animals around the world. Because of the genetic similarities of animals and people, 1

animals are invaluable models for human diseases and are integral to the study of currently incurable diseases like Alzheimer s, Parkinson s, HIV/AIDS and malaria, which together affect more than 280 million people worldwide. Research with animals is currently underway for the development of new drugs to cure or treat such diseases as cancer, cystic fibrosis, tuberculosis, and cardiovascular disease to name a few. The essential role of animals in lifesaving research is an indisputable fact. Almost every major medical advance in the last century was made possible by carefully regulated, humane animal research. For example, the medicines developed and in use today include vaccines against life threatening illnesses such as typhus, yellow fever and polio. These vaccines have essentially eradicated these diseases in the US and Western Europe and provide the tools for eradicating them elsewhere in the world. But there is much research yet to be done and all of it will depend in some way on animals. Be assured that animal research and testing for the development of new medicines are not only required in many cases by the Food and Drug Administration in the United States, but are also strictly regulated by governing authorities in the US, the EU and other countries. Responsible research with animals is a moral and ethical societal obligation to ensure protection of humans and animals from unknown and unacceptable health risks. Access to safe, fast and reliable modes of transportation for these animals is essential to the mission of advancing global medical and scientific progress. By carrying these animals, your company plays a significant role in the quest to end human suffering and premature death, which threaten so much of the world s population. Moreover, air transportation of animals not only promotes good research; it also promotes good animal welfare. The International Air Transport Association (IATA) has stated, In today's modern world, carriage of live animals by air is considered the most humane and expedient method of transportation over long distances. IATA ensures that both safety and animal welfare are addressed in all regulatory issues pertaining to transportation of live animals by air. Thousands of research programs at institutions worldwide are dependent on the shipment of laboratory animals. People at public and private universities, medical and veterinary schools, teaching hospitals, voluntary health agencies, and professional societies are, of course, customers of your airline. These organizations along with biotechnology companies, pharmaceutical companies and contract research organizations spend billions of dollars with the airline industry each year on the shipment of laboratory samples, and medicines and on passenger tickets. We ask you to continue conducting your business with the greater good in mind, rather than capitulating to the opinions of a few vocal animal rights extremists who are not representative of the public at large. A decision to ship research animals doesn t just promote good science, but also 2

promotes a healthy relationship between your airline and all of us, the customers, who rely on the benefits of medical research. We look forward to your response, and would also like to meet with you or your representative to discuss this issue further. Sincerely, Albert Einstein College of Medicine of Yeshiva University Allied Trade Association American Academy of Clinical Toxicology American Academy of Neurology American Association for Corporate and Public Practice Veterinarians American Association for Laboratory Animal Science American Association of Anatomists American Brain Coalition American College of Laboratory Animal Medicine American College of Neuropsychopharmacology American Neurological Association American Physiological Society American Psychological Association American Society for Microbiology American Society for Nutrition American Society for Pharmacology & Experimental Therapeutics American Society of Laboratory Animal Practitioners American Surgical Association Americans for Medical Progress 3

Animal Health Institute Anxiety and Depression Association of America Association for Psychological Science Association of American Medical Colleges Association of American Universities Association of American Veterinary Medical Colleges Association of Independent Research Institutes Association of Primate Veterinarians Association of Public and Land grant Universities Bar Ilan University Baylor College of Medicine Ben Gurion University of the Negev Brigham and Women's Hospital Bioculture Group Bio Serv California Biomedical Research Association California National Primate Research Center California Society for Biomedical Research Canadians for Health Research Caribbean Primate Research Center Cedars Sinai Health System Charles River College on Problems of Drug Dependence Colorado State University Columbia University Medical Center 4

Comparative Biosciences, Inc. Cornell University, Ithaca Council on Governmental Relations Covance, Inc. Creighton University Duke University Duke University Medical Center Emory University Environmental Mutagenesis and Genomics Society European Federation of Pharmaceutical Industries and Associations International Council for Laboratory Animal Science International Essential Tremor Foundation Federation of American Societies for Experimental Biology Federation of European Laboratory Animal Science Associations Florida State University Foundation for Biomedical Research GlaxoSmithKline Groupe Interprofessionnel de Réflexion et de Communication sur la Recherche Harlan Laboratories Hebrew University of Jerusalem Icahn School of Medicine at Mount Sinai Illinois State University Indiana University Inter University Forum for Medical Sciences in Israel Intracranial Hypertension Research Foundation 5

Intuitive Biosciences John A. Burns School of Medicine, University of Hawaii Laboratory Animal Breeders Association Laboratory Animal Management Association Louisiana State University Health Sciences Center New Orleans Loyola University Chicago Health Sciences Division Marshall BioResources Massachusetts General Hospital Massachusetts Institute of Technology Massachusetts Society for Medical Research MdDS Balance Disorder Foundation Michigan State University Mid-Continent Association for Agriculture, Biomedical Research and Education Montana State University National Alliance on Mental Illness National Association for Biomedical Research National Multiple Sclerosis Society Nationwide Children's Hospital New England Primate Research Center New Jersey Association for Biomedical Research New York Medical College New York University North Carolina Association for Biomedical Research Northwest Association for Biomedical Research NYU Langone Medical Center 6

Oklahoma State University Center for Veterinary Health Sciences Oregon National Primate Research Center Ohio Scientific Education & Research Association Pennsylvania Society for Biomedical Research Research!America Rush University Medical Center Safety Pharmacology Society Saint Louis University Salk Institute for Biological Studies Sanofi Scientist Center for Animal Welfare Schizophrenia and Related Disorders Alliance of America SNBL USA, Ltd. Society for Neuroscience Society of Toxicology Society of Toxicologic Pathology Southwest Association for Education in Biomedical Research Southwest National Primate Research Center St. Joseph s Hospital and Medical Center Phoenix, Arizona Stanford University States United for Biomedical Research Taconic Tel Aviv University Teratology Society The American Association of Immunologists 7

The Association of the British Pharmaceutical Industry The Johns Hopkins University The Ohio State University The Rockefeller University The University of Arizona The University of North Carolina at Chapel Hill Technion Israel Institute of Technology Texas Biomedical Research Institute Texas Society for Biomedical Research Tulane National Primate Research Center Tulane University University of Alabama at Birmingham University of Arkansas for Medical Sciences University of California, San Francisco University of California, Davis University of Colorado, Denver University of Florida University of Haifa University of Illinois at Urbana Champaign University of Kentucky University of Maine University of Maryland, College Park University of Michigan University of Minnesota University of Mississippi Medical Center 8

University of Nebraska Medical Center University of Nevada, Reno University of Oklahoma Health Sciences Center University of Pennsylvania University of Pittsburgh Schools of the Health Sciences University of Texas Health Science Center at Houston University of Texas Health Science Center at San Antonio University of Texas Medical Branch at Galveston University of Texas Southwestern Medical Center University of Toledo University of Utah University of Washington University of Wisconsin Madison Virginia Commonwealth University Wake Forest University School of Medicine Washington Animal Research Network Washington National Primate Research Center Washington University Weill Medical College, Cornell University Weizmann Institute of Science Wisconsin National Primate Research Center Yale University Yerkes National Primate Research Center Attachment 9

Attachment Home > Press > Statement Statement Air France would like to state that nothing allows the airline to decide on the merits of the use of animals in biomedical research. However, it is important and scientifically justified, such as, for example, testing new medical products on the market which need to be proven safe for humans, in line with international regulations. Animals are also used in basic research for new vaccines and in studies of the safety of pharmaceutical products. Air France Cargo refuses to transport laboratory animals destined for any use other than medical. In addition, Air France Cargo ensures that all biomedical research involving the use of animals in laboratories with which the airline works is fully in line with current legislation and the regulations drawn up by scientific organizations specializing in animal welfare. Air France Cargo refuses transportation if the testing protocols do not conform to these regulations and visits all customers to make sure this is the case. Air France Cargo also monitors the supplier, who must comply with the breeding rules in force. More generally, Air France scrupulously respects and complies with standards issued by the International Air Transport Association (IATA), the European Union, the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) and the World Organization for Animal Health (OIE). 10