ACTELION LTD AND SUBSIDIARIES CONSOLIDATED US GAAP FINANCIAL STATEMENTS FOR DECEMBER 31, Contents:

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CONSOLIDATED US GAAP FINANCIAL STATEMENTS FOR DECEMBER 31, 2016 Contents: CONSOLIDATED INCOME STATEMENTS CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME CONSOLIDATED BALANCE SHEETS CONSOLIDATED STATEMENTS OF CASH FLOWS CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY

CONSOLIDATED INCOME STATEMENTS Three months ended Twelve months ended (in CHF thousands, except per share amounts) 2016 2015 2016 2015 Net revenue Product sales 626'881 519'334 2'412'198 2'041'515 Contract revenue 60 421 5'740 3'547 Total net revenue 626'941 519'755 2'417'938 2'045'062 Operating (expenses) 1 Cost of sales 2 (91'446) (45'129) (245'537) (175'794) Research and development (168'586) (132'664) (568'534) (463'842) Selling, general and administration (224'488) (206'297) (760'158) (696'650) Amortization of acquired intangible assets (13'833) (13'213) (54'997) (53'131) Total operating (expenses) (498'353) (397'303) (1'629'226) (1'389'417) Operating income 128'588 122'452 788'712 655'645 Interest income (expense), net 578 (1'903) 1'183 (8'186) Other financial income (expense), net (694) 786 2'539 (11'977) Total financial income (expenses) (116) (1'117) 3'722 (20'163) Income before income tax benefit (expense) 128'472 121'335 792'434 635'482 Income tax benefit (expense) (13'748) (22'394) (97'599) (87'547) Net income 114'724 98'941 694'835 547'935 Less: Net loss attributable to the noncontrolling interests 303 752 1'551 3'924 Net income attributable to Actelion's shareholders 115'027 99'693 696'386 551'859 Basic net income per share attributable to Actelion's shareholders 1.11 0.94 6.66 5.09 Weighted-average number of common shares (in thousands) 103'349 105'697 104'626 108'320 Diluted net income per share attributable to Actelion's shareholders 1.08 0.91 6.46 4.91 Weighted-average number of common shares (in thousands) 106'236 109'718 107'811 112'484 1 Includes stock-based compensation as follows: Research and development (6'990) (5'956) (27'199) (23'561) Selling, general and administration (10'383) (9'044) (38'025) (33'235) Total stock-based compensation (17'373) (15'000) (65'224) (56'796) 2 Excludes amortization of intangible assets as presented separately.

CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME Three months ended Twelve months ended (in CHF thousands) 2016 2015 2016 2015 Net income 114'724 98'941 694'835 547'935 Other comprehensive income (loss), net of tax: Foreign currency translation adjustments (10'880) (3'462) (4'089) (28'485) Change of unrecognized components of net periodic benefit costs 5'231 1'810 5'231 (3'672) Amortization of components of net periodic benefit costs 240 456 1'433 1'875 Other comprehensive income (loss), net of tax (5'409) (1'196) 2'575 (30'282) Comprehensive income 109'315 97'745 697'410 517'653 Less: Comprehensive loss attributable to noncontrolling interests 303 752 1'551 3'924 Comprehensive income attributable to Actelion's shareholders 109'618 98'497 698'961 521'577

CONSOLIDATED BALANCE SHEETS (in CHF thousands, except number of shares) 2016 2015 Assets Current assets Cash and cash equivalents 495'380 404'892 Trade and other receivables, net 445'868 427'223 Inventories 135'820 62'107 Other current assets 115'763 68'828 Total current assets 1'192'831 963'050 Noncurrent assets Property, plant and equipment, net 350'215 348'277 Intangible assets, net 382'705 413'542 Goodwill 135'048 134'494 Deferred tax assets 20'528 39'159 Other noncurrent assets 25'150 16'415 Total noncurrent assets 913'646 951'887 Total assets 2'106'477 1'914'937 Liabilities Current liabilities Trade and other payables 83'009 83'878 Accrued expenses 445'730 302'729 Other current liabilities 40'211 34'375 Total current liabilities 568'950 420'982 Noncurrent liabilities Pension liability 66'427 67'204 Contingent considerations 115'630 83'759 Other noncurrent liabilities 34'312 27'979 Total noncurrent liabilities 216'369 178'942 Total liabilities 785'319 599'924 Equity Actelion's shareholders' equity Common shares (par value CHF 0.50 per share; authorized 147,753,077 and 154,120,627; issued 107,761,427 and 114,128,427 shares in 2016 and 2015, respectively) 53'881 57'064 Accumulated profit 2'187'889 2'636'931 Treasury shares, at cost (680'053) (1'137'399) Accumulated other comprehensive income (loss) (236'220) (238'795) Total Actelion's shareholders' equity 1'325'497 1'317'801 Noncontrolling interests Equity attributable to noncontrolling interests (4'339) (2'788) Total equity 1'321'158 1'315'013 Total liabilities and equity 2'106'477 1'914'937

CONSOLIDATED STATEMENTS OF CASH FLOWS Three months ended Twelve months ended (in CHF thousands) 2016 2015 2016 2015 Cash flow from operating activities Net income 114'724 98'941 694'835 547'935 Adjustments to reconcile net income to net cash provided from operating activities: Depreciation and amortization 22'714 22'436 87'879 89'500 Stock-based compensation, incl. treasury shares to members of Board of Directors 17'606 15'247 66'166 57'753 Excess tax benefits from share-based payment arrangements (2'571) (2'180) (15'097) (13'415) Deferred taxes (7'315) 1'334 30'353 52'068 Deferred revenue (386) 143 (354) (527) (Gains) Losses on derivative instruments (3'685) (190) (10'300) (24'759) Interest expense on bonds - (8'452) - 545 Accretion expense (benefit) on contingent considerations 27'419 3'611 37'025 387 Changes in operating assets and liabilities: Trade and other receivables 46'758 (13'155) (12'433) (31'371) Inventories (15'463) (3'447) (73'768) (1'609) Trade and other payables (11'288) (1'948) 12'575 (5'190) Accrued expenses 69'896 39'216 140'163 328 Changes in other operating cash flow items (33'493) (26'772) (37'514) (13'967) Net cash flow provided by (used in) operating activities 224'916 124'784 919'530 657'678 Cash flow from investing activities Purchase of property, plant and equipment (14'527) (7'023) (32'804) (18'703) Purchase of intangible assets (1'296) (22'384) (24'638) (25'277) Acquisition of a business, incl. contingent consideration payments (993) (5'960) (4'239) (8'015) Net cash flow provided by (used in) investing activities (16'816) (35'367) (61'681) (51'995) Cash flow from financing activities Debt repayment - (235'000) - (235'000) Dividend payment - 39 (158'513) (142'390) Payments on capital leases - - - (3) Proceeds from exercise of stock options, net of expense 14'217 11'999 39'263 78'936 Purchase of treasury shares (138'229) (165'734) (662'967) (1'111'918) Excess tax benefits from share-based payment arrangements 2'571 2'180 15'097 13'415 Contributions from noncontrolling interests' owners - - - 1'136 Net cash flow provided by (used in) financing activities (121'441) (386'516) (767'120) (1'395'824) Net effect of exchange rates on cash and cash equivalents (1'989) 3'502 (241) (9'925) Net change in cash and cash equivalents 84'670 (293'597) 90'488 (800'066) Cash and cash equivalents at beginning of period 410'710 698'489 404'892 1'204'958 Cash and cash equivalents at end of period 495'380 404'892 495'380 404'892

CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY Actelion's shareholders Noncontrolling interests (in CHF thousands, Additional Accum. other Equity attrib. to except number of shares) Common shares paid-in Accumulated Treasury comprehensive noncontrolling Total Shares Amount capital profit shares income (loss) interests equity At January 1, 2015 111'128'427 57'064-2'359'573 (287'701) (208'513) - 1'920'423 Comprehensive income (loss) 1) : Net income 551'859 (3'924) 547'935 Other comprehensive income (loss) (30'282) (30'282) Comprehensive income (loss) 1) 517'653 Excess tax benefits from share-based payments 10'065 10'065 Transactions in treasury shares (6'059'510) 75'989 (274'501) (849'698) (1'048'210) Stock-based compensation expense 56'336 56'336 Dividend payment (142'390) (142'390) Contributions from owners 1'136 1'136 At December 31, 2015 105'068'917 57'064-2'636'931 (1'137'399) (238'795) (2'788) 1'315'013 Comprehensive income (loss) 1) : Net income 696'386 (1'551) 694'835 Other comprehensive income (loss) 2'575 2'575 Comprehensive income (loss) 1) 697'410 Excess tax benefits from share-based payments 10'263 10'263 Transactions in treasury shares (1'961'715) 83'927 (308'175) (383'090) (607'338) Stock-based compensation expense 64'323 64'323 Cancellation treasury shares (share repurchase program) (3'183) - (837'253) 840'436 - Dividend payment (158'513) (158'513) At December 31, 2016 103'107'202 53'881-2'187'889 (680'053) (236'220) (4'339) 1'321'158 1) Comprehensive income (loss) is presented net of tax.