SUPPLEMENT DATED 9 MAY 2016 TO THE BASE PROSPECTUS DATED 30 NOVEMBER 2015

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SUPPLEMENT DATED 9 MAY 2016 TO THE BASE PROSPECTUS DATED 30 NOVEMBER 2015 Abbey National Treasury Services plc (incorporated in England and Wales with limited liability, registered number 2338548) Unconditionally guaranteed by Santander UK plc (incorporated in England and Wales with limited liability, registered number 2294747) This supplement ("this Supplement"), which definition shall also include all information incorporated by reference herein is prepared as a supplement to, and must be read in conjunction with the Base Prospectus dated 30 November 2015 relating to the Structured Note and Certificate Programme (the "Base Prospectus"). This Supplement together with the Base Prospectus constitutes a base prospectus for the purposes of Article 5.4 of Directive 2003/71/EC, as amended (which includes the amendments made by Directive 2010/73/EU to the extent that such amendments have been implemented in a relevant Member State of the European Economic Area) (the "Prospectus Directive")). Terms defined in the Base Prospectus have the same meaning when used in this Supplement. This Supplement constitutes a supplementary prospectus for the purposes of Article 16 of the Prospectus Directive and is supplemental to, and should be read in conjunction with the Base Prospectus and any other supplements to the Base Prospectus prepared by Abbey National Treasury Services plc., as issuer on the Structured Note and Certificate Programme. This Supplement has been approved by the Central Bank of Ireland (the "Central Bank"), as Irish competent authority under the Prospectus Directive. The Central Bank only approves this Supplement as meeting the requirements imposed under Irish and EU law pursuant to the Prospectus Directive. Such approval relates only to the Securities which are to be admitted to trading on the regulated market of the Irish Stock Exchange or other regulated markets for the purposes of Directive 2004/39/EC (the "Markets in Financial Instruments Directive") or which are to be offered to the public in a Member State of the European Economic Area. Each of Abbey National Treasury Services plc and Santander UK plc (each an "Obligor") accept responsibility for the information contained in this Supplement. To the best of the knowledge of each Obligor (having taken all reasonable care to ensure that such is the case) the information contained in this Supplement is in accordance with the facts and does not omit anything likely to affect the import of such information. This Supplement has been prepared for the purpose of: (i) incorporating by reference into the Base Prospectus by this Supplement certain sections of the Santander UK plc Annual Report for year ended 31 December 2015 and Abbey National Treasury Services plc Annual Report for year ended 31 December 2015 (as specified in Schedule 1 hereto); (ii) incorporating by reference into the Base Prospectus by this Supplement the unaudited consolidated financial information of Santander UK plc for the three months ended 31 March 2016 (the "Quarterly Financial Information") and (iii) updating the Summary of the Programme commencing on page 1 of the Base Prospectus (as described in Schedule 2 hereto). To the extent that there is any inconsistency between (a) any statement in this Supplement or any statement incorporated by reference in the Base Prospectus by this Supplement and (b) any other statement in or 1

incorporated by reference in the Base Prospectus prior to the date of this Supplement, the statement in (a) above will prevail. If any documents which are incorporated by reference themselves incorporate any information or other documents therein, either expressly or implicitly, such information or other documents will not form part of this Supplement or the Base Prospectus for the purposes of the Prospectus Directive except where such information or other documents are specifically incorporated by reference or attached to this Supplement. Any non-incorporated parts of a document referred to herein are either deemed not relevant for an investor or are otherwise covered elsewhere in the Base Prospectus, to which this Supplement relates. Save as disclosed in this Supplement, no significant new factor, material mistake or inaccuracy relating to information included in the Base Prospectus has arisen or been noted, as the case may be, since the publication of the Base Prospectus. There has been no significant change in the financial position of Santander UK plc and its subsidiaries since 31 March 2016 (being the date to which the most recent financial information was prepared). In circumstances where Article 16.2 of the Prospectus Directive apply, investors who have agreed to purchase or subscribe for securities before this Supplement is published have the right, exercisable before the end of the period of two working days beginning with the working day after the date on which this Supplement was published, to withdraw their acceptances by sending a written notice of withdrawal (which must include the full name and address of the person or entity wishing to exercise such statutory withdrawal right and identify the transferable securities to which that statutory withdrawal right relates) by electronic mail to WholesaleMarketsLegal@santander.co.uk The date of this Supplement is 9 May 2016. 2

SCHEDULE 1 PUBLICATION OF ANNUAL REPORT AND QUARTERLY FINANCIAL INFORMATION 1. Santander UK plc 1.1 On 25 February 2016, Santander UK plc published its Annual Report for the year ended 31 December 2015 (the "Santander UK 2015 Annual Report") which contained the following information which is hereby incorporated in, and forms part of, Base Prospectus: - Santander UK 2015 Annual Report (which include the audited consolidated annual financial statements of the Guarantor), excluding the sections entitled "Risk factors" on pages 300 to 320 inclusive thereof and "Contact and other information" on page 321. 1.2 On 27 April 2016, Santander UK Group Holdings plc, the immediate parent company of Santander UK plc, published its unaudited quarterly management statement for the three months ended 31 March 2016 (the Quarterly Management Statement ). The content of Appendix 4 appearing on page 24 of such Quarterly Management Statement, which contains the Quarterly Financial Information of Santander UK plc, is hereby incorporated in, and forms part of the Base Prospectus. 2. Abbey National Treasury Services plc On 26 February 2016, Abbey National Treasury Services plc published its Annual Report for the year ended 31 December 2015 (the "ANTS 2015 Annual Report") which contained the following information which is hereby incorporated in, and forms part of, the Base Prospectus: - ANTS 2015 Annual Report (which include the audited consolidated annual financial statements of the Issuer), excluding the sections entitled "Risk factors" on pages 164 to 184 inclusive thereof and "Contact and other information" on page 185. Copies of the Santander UK 2015 Annual Report, the ANTS 2015 Annual Report of the Quarterly Management Statement and have been submitted to the National Storage Mechanism (available for viewing at: http://www.morningstar.co.uk/uk/nsm). The relevant sections of the Santander UK 2015 Annual Report are available at: http://www.santander.co.uk/csdlvlr/contentserver?c=sandocument_c&pagename=wcsukpublicalte%2 FSANDocument_C%2FSANDocumentPreview&cid=1324582192027 The relevant sections of the ANTS 2015 Annual Report are available at: http://www.santander.co.uk/csdlvlr/contentserver?c=sandocument_c&pagename=wcsukpublicalte%2 FSANDocument_C%2FSANDocumentPreview&cid=1324582200140 The relevant sections of the Quarterly Management Statement listed above are also available for viewing at: http://www.santander.co.uk/csdlvlr/contentserver?c=sandocument_c&pagename=wcsukpublicalte%2 FSANDocument_C%2FSANDocumentPreview&cid=1324582346639 3

SCHEDULE 2 SUPPLEMENT TO THE SUMMARY SECTION B ISSUER AND GUARANTOR ISSUER: The summary document which forms part of the Base Prospectus is hereby supplemented below following the publication of the Abbey National Treasury Services plc Annual Report for year ended 31 December 2015 by deletion of Element B.12 relating to Abbey National Treasury Services plc commencing on page 3 of the Base Prospectus and its replacement with the following: B.12 Selected historical key financial information The audited consolidated balance sheet as at 31 December 2014 and 31 December 2015 and audited consolidated income statement for each of the years ended 31 December 2014 and 31 December 2015 have been extracted without any adjustment from, and should be read in conjunction with, the Issuer's consolidated financial statements in respect of those dates and periods: Consolidated Balance Sheet (extracted from the Issuer s financial report for the year ended 31 December 2015) 31 December 2015 31 December 2014 Assets Cash and balances at central banks 2,279 4,460 Trading assets 23,649 21,373 Derivative financial instruments 24,875 25,792 Financial assets designated at fair value 2,130 2,577 Loans and advances to banks 21,544 11,344 Loans and advances to customers 32,455 38,285 Loans and receivables securities 15 22 Available-for-sale securities 1,168 2,525 Macro hedge of interest rate risk 521 935 Intangible assets 25 13 Property, plant and equipment 12 10 Other assets 194 133 Total assets 108,867 107,469 Liabilities Deposits by banks 21,333 17,416 Deposits by customers 2,838 4,523 Trading liabilities 12,722 15,333 Derivative financial instruments 25,178 26,607 Financial liabilities designated at fair value 2,016 2,848 Debt securities in issue 40,811 36,799 Macro hedge of interest rate risk - 39 Other liabilities 163 255 Provisions 44 32 Current tax liabilities 104 224 Deferred tax liabilities 15 12 Total liabilities 105,224 104,088 Equity Share capital 2,549 2,549 Retained earnings 1,027 761 Other reserves 67 71 Total shareholders equity 3,643 3,381 Total liabilities and equity 108,867 107,469 4

Consolidated Income Statement (extracted from the Issuer s financial report for the year ended 31 December 2015) 31 December 2015 31 December 2014 Interest and similar income 1,495 2,518 Interest expense and similar charges (1,223) (2,483) Net interest income/(expense) 272 35 Net fee and commission income 114 122 Net trading and other income 252 299 Total operating income 638 456 Operating expenses before impairment losses, provisions and charges (255) (256) Impairment losses on loans and advances 5 (30) Provisions for other liabilities and charges (43) (32) Total operating impairment losses, provisions and charges (38) (62) Profit before tax 345 138 Tax on profit (79) (17) Profit after tax for the year 266 121 Attributable to: Equity holders of the parent 266 121 Statements of no significant or material adverse change There has been no significant change in the financial position of the ANTS Group (including the Issuer) since 31 December 2015 and there has been no material adverse change in the prospects of the Issuer since 31 December 2015. GUARANTOR: The summary document which forms part of the Base Prospectus is hereby supplemented below following the publication of the Santander UK plc Annual Report for year ended 31 December 2015 by deletion of Element B.12 relating to Santander UK plc commencing on page 6 of the Base Prospectus and its replacement with the following: B.12 Selected historical key financial information The audited consolidated balance sheet as at 31 December 2015, and audited consolidated income statement for the year ended 31 December 2015, have been extracted without any adjustment from, and should be read in conjunction with, the Guarantor s consolidated financial statements in respect of the dates and periods. The audited consolidated balance sheet as at 31 December 2014, and audited consolidated income statement for the year ended 31 December 2014, as set out below have been extracted from, and should be read in conjunction with, the Guarantor's audited consolidated annual financial statements for the financial year ended 31 December 2014 and reflect the adjusted figures. The unaudited summary of segmental balance sheet assets and liabilities as of 31 March 2016 and 31 December 2015 and unaudited summarised consolidated income statement for the three months ended 31 March 2016 and 31 March 2015 have been extracted without any adjustment from the unaudited quarterly management statement for the three months ended 31 March 2016 of Santander UK Group Holdings plc (the Quarterly Management Statement), the immediate parent company of the Guarantor. Consolidated Balance Sheet (extracted from the Guarantor s financial report for the year ended 31 December 2015) 31 December 2015 31 December 2014 Assets Cash and balances at central banks 16,842 22,562 Trading assets 23,961 21,700 Derivative financial instruments 20,911 23,021 Financial assets designated at fair value 2,398 2,881 Loans and advances to banks 3,548 2,057 5

Loans and advances to customers 198,045 188,691 Loans and receivables securities 52 118 Available-for-sale securities 9,012 8,944 Macro hedge of interest rate risk 781 963 Interests in other entities 48 38 Intangible assets 2,231 2,187 Property, plant and equipment 1,597 1,624 Current tax assets 49 - Retirement benefit assets 556 315 Other assets 1,375 876 Total assets 281,406 275,977 Liabilities Deposits by banks 8,278 8,214 Deposits by customers 164,074 153,606 Trading liabilities 12,722 15,333 Derivative financial instruments 21,508 22,732 Financial liabilities designated at fair value 2,016 2,848 Debt securities in issue 49,615 51,790 Subordinated liabilities 3,885 4,002 Macro hedge of interest rate risk 110 139 Other liabilities 2,335 2,302 Provisions 870 491 Current tax liabilities 1 69 Deferred tax liabilities 223 59 Retirement benefit obligations 110 199 Total liabilities 265,747 261,784 Equity Share capital and other equity instruments 4,911 4,244 Share premium 5,620 5,620 Retained earnings 4,679 4,056 Other reserves 314 273 Total shareholders equity 15,524 14,193 Non-controlling interests 135 - Total equity 15,659 14,193 Total liabilities and equity 281,406 275,977 Summary of segmental balance sheet assets and liabilities (extracted from the Quarterly Management Statement) 31 March 2016 (unaudited) bn 31 December 2015 (audited) bn Customer loans Retail Banking 166.0 164.8 Commercial Banking 21.2 20.9 Global Corporate Banking 6.3 5.5 Corporate Centre 7.4 7.4 Total customer loans 200.9 198.6 Other assets 87.8 82.8 Total assets 288.7 281.4 Customer deposits Retail Banking 138.9 137.3 Commercial Banking 18.1 18.1 Global Corporate Banking 3.0 3.0 Corporate Centre 3.3 3.9 6

Total customer deposits 163.3 162.3 Medium Term Funding (MTF) 1 52.2 50.4 Other liabilities 57.0 53.0 Total liabilities 272.5 265.7 Shareholders equity 16.1 15.6 Non-controlling interest 0.1 0.1 Total liabilities and equity 288.7 281.4 1. Medium term funding includes downstreamed funding, in the form of loans that rank pari passu with existing senior unsecured liabilities, from Santander UK Group Holdings plc. Consolidated Income Statement (extracted from the Guarantor s financial report for the year ended 31 December 2015) Year ended 31 December 2015 Year ended 31 December 2014 Interest and similar income 6,695 6,797 Interest expense and similar charges (3,120) (3,363) Net interest income 3,575 3,434 Fee and commission income 1,115 1,095 Fee and commission expense (400) (356) Net fee and commission income 715 739 Net trading and other income 283 297 Total operating income 4,573 4,470 Operating expenses before impairment losses, provisions and charges (2,400) (2,397) Impairment losses on loans and advances (66) (258) Provisions for other liabilities and charges (762) (416) Total operating impairment losses, provisions and charges (828) (674) Profit from continuing operations before tax 1,345 1,399 Tax on profit from continuing operations (381) (289) Profit from continuing operations after tax 964 1,110 Loss from discontinued operations after tax - - Profit after tax for the year 964 1,110 Attributable to: Equity holders of the parent 939 1,110 Non-controlling interests 25 - Summarised consolidated income statement (extracted from the Quarterly Management Statement) 31 March 2016 (unaudited) bn 31 March 2015 (unaudited) bn Net interest income 885 885 Non-interest income 1 270 258 Total operating income 1,155 1,143 Operating expenses before impairment losses, provisions and charges (598) (602) Impairment losses on loans and advances (13) (53) Provisions for other liabilities and charges (11) (18) Total operating impairment losses, provisions and charges (24) (71) Profit before tax 533 470 Tax on profit (154) (93) Profit after tax for the period 379 377 1. Comprised of Net fee and commission income and Net trading and other income. 7

Statements of no significant or material adverse change There has been no significant change in the financial position of the Santander UK Group (including the Guarantor) since 31 March 2016 and there has been no material adverse change in the prospects of Santander UK plc since 31 December 2015. 8