FUSION MESOTHERAPY The revolution in mesotherapy

Presentation 1. Concept 1. The technology 2. Advantages 3. Indications & counter indications 1. Products & protocols 2. Sales potential & Prices

Concept FUSION MESOTHERAPY is a new concept in non-invasive aesthetic medicine. A new mesotherapy approach based on breakthrough systems and products. Fusion mesotherapy (needle-free) is a radiofrequency (RF) based device. It enhances the transdermal transport of topical products, through the epidermis to the dermis. The radiofrequency (RF) produces a cellular electroporation reducing the permeability of the skin and opening cellular pores. At the same time the radio-frequency (RF) increases the skin temperature of 2 to 4ºC to stimulate the collagen synthesis and skin tightening. Fusion mesotherapy (with needle), consists in combining sub-cutaneous injector (conventional mesotherapy MESO-PEN device) and the radiofrequency (RF) device. This technique improves the effectiveness of injected products and the results. It has been demonstrated by clinical study to be very effective for lipolysis offering a real alternative to plastic surgery lipoplasty and lipo-lasers.main INDICATIONS: Skin rejuvenation, expression wrinkles, wrinkles, skin tightening, whitening, acne, anticellulite, lipolysis, sport medicine etc.

+ + + NEEDLE FREE TREATMENT NEEDLE TREATMENT

Concept FUSION MESOTHERAPY NEEDLE FREE: "Needle-free" FUSION " is without doubt offering all the advantages in non-invasive and painless skin rejuvenation: safety, efficency, easy to operate, cost-effectiveness, immediate and long-lasting results.it enhances the transdermal transport of topical products, through the epidermis to the dermis. The radiofrequency (RF) produces a cellular electroporation reducing the permeability of the skin and opening cellular pores. At the same time the radio-frequency (RF) increases the skin temperature of 5 to 7ºC to stimulate the collagen synthesis and skin tightening.this technology has been successfully used to enhance the skin permeability to molecules with differing lipophilicity and size including biopharmaceuticals with molecular weights greater that 20 kda. In addition the effect of the device on the skin is 100% reversible with no damage to the epidermis and no morphological modifications. * Our device is producing a slight heat that increases the skin temperature of 5 to 7ºC to stimulate the collagen synthesis and skin tightening. At the same time the diffusion of active ingredients doubles thanks to the temperature effect. * Using our skin care formulation is of the greatest importance to obtain the best results.

Concept FUSION MESOTHERAPY WITH NEEDLE: Fusion mesotherapy is a synergy of 2 techniques: mesotherapy and radiofrequency (RF) producing electroporation (cellular permeability) and heat. The effectiveness of subcutaneous injections are improved by a higher product dissemination in the tissues and a higher cellular transfer. The side effects of mesotherapy are also reduced. This technique can be applied for face and body. A clinical study was performed on lipolysis by mesotherapy vs fusion mesotherapy showing interesting results and offering in a short future similar results as lipo-lasers or plastic surgery. - A reduction of 50% of the side effects including oedema, pain bruises. - Ultrasound images show a hyperrecogenesis more homogeneous as an expression of higher effectiveness and dissemination. - In histopathology, the sections show varying degrees of subcutaneous cell tissue damage. There is reversible (hydropic, balloon-like degeneration) and irreversible (fat necrosis with lipogranuloma formation) cell damage. In all cases, there was a higher effect of fat cellular lysis on the side, treated by Fusion Mesotherapy.

Technology Fusion Mesotherapy is a Radio Frequency device. It emits pulsed radio frequencies at different intensities (from 600 volts to 2200 Volts) and frequency (from 0,5 MHz to 1,5 Mhz) depending on treatment. These electromagnetic pulses are producing a transitory structural perturbation of lipid bilayers membrane of cells also called electroporation. Channels are opened on the cellular membrane of the cells permitting the products to be introduced through the skin by transcellular pathway and also reach the heart of the cells. Many publication and clinical studies have demonstrated the effectiveness of electroporation for transdermal delivery. It's also used in RNA vaccine to increase cellular transfer and immune response, cancer tumor treatment by electro chemotherapy, gene therapy etc.

Technology In Fusion Mesotherapy with needle the product is injected and the radio frequencies are applied at the same time. The consequence is that much more products diffuse into the cells and is disseminated more evenly into the tissue (muscle or fat tissue). The product is acting directly and immediately in the dermis or in muscles. (please check the clinical study of lypolisis by Fusion Mesotherapy with PPC). - Improve effectiveness of 20% - improves diffusion of the products - reduces sides effect up to 50% In Fusion Mesotherapy without needle the product is applied over the skin and diffuses through the deep epidermis during the treatment. 24 to 48 hours after the treatment the products will continue to diffuse to the dermis by the blood vessels. The treatment is effective for superficial skin & low quantities of product is reaching the dermis. Tests have been performed with Indian Ink to track the products and the diffusion to confirm the effectiveness of the device. Other parameters are also of great importance for transdermal delivery and are detailled here after.

Technology Parameters of devices to reach high trasndermal delivery: - Pulse voltage higher + - Pulse length longer + - Pulse number + - Contact time of the probe on the skin + - Moderate temperature effect + Parameters of products to reach high trasndermal delivery: - Low viscosity + - Low molecular weight + - Polarity + - Skin transfer boosters (lecithin, propylene glycol etc.) + - No competitive ions + Parameters of products for patient safety: - Low preservative or sterilized products - No coloring - No perfume - No animal extracts - No allergens

Advantages Advantages of Fusion Mesotherapy with needle - Non invasive - Easy practice - Adjustable injection depth and product quantity per injection point - All kind of products - No molecular desintegration - No morphological damages - Wide applications (medicine & aesthetic medicine) - Clinically proven - Improve the effectiveness of products - Reduces side effects and pain - Increase diffusion of the product - Low cost of consumables (same as mesotherapy) Advantages of Fusion Mesotherapy without needle - Non invasive - Easy practice - All kind of products - No molecular desintegration - No morphological damages - Wide applications (medicine & aesthetic medicine) - Clinically proven - Low cost of consumables (only products) Advantages of devices - LCD control - Made in France & CE certifies

Indications Indications of Fusion Mesotherapy with needle - Sport medicine - Facial rejuvenation - Pigmentation - Cellulite - Lypolisis - All other mesotherapy applications Indications of Fusion Mesotherapy without needle - Sport medicine - Face care - Wrinkles - Expression wrinkles - Facial rejuvenation - Pigmentation - Cellulite - Acne

Counter Indications Counter Indications of Fusion Mesotherapy with needle - Metallic implants - Pace maker - Epilepsy - Hyper sensitivity to electromagnetic field - Allergy to injected product - Cancer - Systemic and local Infections - Diabetics - Pregnant counter Indications of Fusion Mesotherapy without needle -Metallic implants - Pace maker - Epilepsy - Hyper sensitivity to electromagnetic field - Allergy to injected product - Cancer - Systemic and local Infections -Diabetics - Pregnant

Products Cocktails (Preservative, perfume, coloring, and silicone free) - LIFT BTX: Expression wrinkles treatment (Pentapeptide & octapeptide). - EYE CONTOUR: Treatment against eye bags, dark circles and wrinkles (amino acids, peptides, organic silicon, hyal. Acid, natural extracts). - FACE: Facial rejuvenation cocktail (DMAE 0,5%, organic silicon 0,5%, hyaluronic acid low molecular weight 1%). - RADIANCE: Facial lightening & pigmentation cocktail (Vitamin C, gluthation, glycolic acid, kojic & azelaic acid, arbutin, natural extracts). - VITAMINS: Facial rejuvenation cocktail (Vitamin A 1%, vitamin C 3%, vitamin E 0,5%). - HYALURONIC ACID: Facial moisturizing and wrinkle filling cocktail (Hyaluronic acid low molecular weight 2%). - HAIR: Anti hair loss cocktail (Biotin, hyaluronic acid low molecular weight, organic silicon, minerals, dexpanthenol). - GS PEEL: Soft peeling, oily skin and acne treatment (Glycolic acid 5%, Salicylic acid 2%). - BODY: Body cocktail (Caffeine, carnitine, organic silicon, witch hazel, cynara, rutin, coumarin). Skin care creams (Parabens, perfume, coloring, and silicone free) - CLEANSING CREAM: All in one soft cleanser. - PEELING CREAM: Enzymatic peeling cream. - FACE CREAM: Post treatment soothing, anti-ageing, moisturizing and nourishing cream. - FACE MASK: Post treatment soothing, anti-ageing, moisturizing and nourishing cream. - BODY CREAM: Post treatment slimming cream Matrix (Preservative, perfume, and silicone free) - LIFT BTX matrix: Second skin collagen mask for expression wrinkles (Peptides). - FACE matrix: Second skin pure collagen mask soothing and anti-ageing (Pure collagen). - RADIANCE matrix: Second skin collagen mask reducing pigmentation (Alpha arbutin, ectoin) - HYALURONIC ACID matrix: Second skin collagen mask moisturizing and anti-wrinkles (Hyaluronic acid). - VITAMIN matrix: Second skin collagen mask anti-ageing and free radical scavenger (Vitamin C).

Protocols FUSION MESOTHERAPY WITH MESO-PEN (NEEDLE) 1-Prepare the solution to be injected and put the syringe on the Meso-Pen 2- Introduce the parameters on the meso-pen (quantity of product to inject on each point and injection depth) 3- Clean the area to be treated first with the cleanser and with alcohol 4- Connect the Fusion Mesotherapy device to the meso-pen 5- Inject the whole area 6- When done clean with alcohol. 7- Apply a collagen matrix & a cream MESO ENERGY PROBES (NEEDLE-FREE) 1- Prepare the cocktail to be applied 2- Clean the skin with the cleanser 3- Exfoliate the skin peeling cream 4- Apply the dermaroller (depending on the treatment) 5- Apply the serum with the appropriate probe and the desired level of energy (sensitive, medium or intensive) 6- Apply a the mask or a matrix during 10 to 20 minutes 7- Apply the cream

Before & after pictures After 1 session (XFC + F Peel)

Before & after pictures

Marketing kit Includes: Posters, Flyers, Waiting room video, Appointments cards, Triptyc, Check up forms.

Competitive advantages A- Wide target of potential customers: 1- Doctors already using mesotherapy, 2- Anti-aging physicians, 3- Aesthetics doctors, 4- Dermatologists, 5- Plastic surgeon, 6- Sport medicine practitioners. B- Exclusive and unique concept C- Supported by clinical studies D- Made in France E- Young brand image F- Competitive pricing of products and device 27/11/09