Investor Presentation June NASDAQ: MTLS

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Investor Presentation June 2016 www.materialise.com NASDAQ: MTLS

Safe Harbor Summary This presentation contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, regarding, among other things, our intentions, beliefs, assumptions, projections, outlook, analyses or current expectations, plans, objectives, strategies and prospects, both financial and business, including statements concerning, among other things, current estimates of fiscal 2015 revenues and Adjusted EBITDA, investments in R&D and S&M initiatives, results of operations, cash needs, capital expenditures, expenses, financial condition, liquidity, prospects, growth and strategies, and the trends and competition that may affect the markets, industry or us. Such statements are subject to known and unknown uncertainties and risks. When used in this presentation, the words estimate, expect, anticipate, project, plan, intend, believe, forecast, will, may, could, might, aim, should, and variations of such words or similar expressions are intended to identify forward-looking statements. These forward-looking statements are based upon the expectations of management under current assumptions at the time of this press release. These expectations, beliefs and projections are expressed in good faith and the company believes there is a reasonable basis for them. However, the company cannot offer any assurance that our expectations, beliefs and projections will actually be achieved. By their nature, forward-looking statements involve risks and uncertainties because they relate to events, competitive dynamics and industry change, and depend on economic circumstances that may or may not occur in the future or may occur on longer or shorter timelines than anticipated. We caution you that forward-looking statements are not guarantees of future performance and involve known and unknown risks, uncertainties and other factors that are in some cases beyond our control. All of the forward-looking statements are subject to risks and uncertainties that may cause the company's actual results to differ materially from our expectations, including the risk factors described in Item 3.D. of our Annual Report on Form 20-F filed with the SEC on April 28, 2016. There are a number of risks and uncertainties that could cause the company's actual results to differ materially from the forward-looking statements contained in this press release. The company is providing this information as of the date of this presentation and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise, unless it has obligations under the federal securities laws to update and disclose material developments related to previously disclosed information. Materialise, the Materialise logo, Magics, Streamics, 3-matic, i.materialise, and Mimics are trademarks of Materialise NV. 2

25 Years of Software Innovation From the very beginning, Materialise has focused on the software and services that put 3D printers to work. 3

Industrial Manufacturing Ecosystem 4

Industrial Manufacturing Backbone 5

Industrial 3D Printing Ecosystem & Backbone 6

Materialise: the Backbone of the 3D Printing Ecosystem 7

Our Strategy at a Glance Materialise has incorporated more than 25 years of 3D printing experience into a suite of software solutions and 3D printing services, that together form the backbone of the 3D printing industry. Our open and flexible solutions enable all players in the ecosystem to build innovative 3D printing applications that will make the world a better and healthier place. 8

Our Competitive Edge Our backbone is open to all players in the 3D printing ecosystem, offering them a neutral and flexible platform to build meaningful applications. We are the only company that combines the largest group of software developers in the industry with one of the largest 3D printing facilities in the world. We have 25 years of experience. We are global. We have a portfolio of over 95 granted patents and more than 165 pending. 9

Who Our Backbone Supports Those who 3D print, Rely on our software tools to optimize the print files, to prepare the build platform and to better control the printing process; Those who subcontract the 3D printing of prototypes or end-use parts, Turn to us to (re-)engineer and 3D print their most complex designs, using our wide variety of technologies and materials, which can operate in highly regulated and certified environments; Those who introduce 3D Printing to their businesses, For healthcare applications, they work with our planning and design software tools, rely on our 3D-printed anatomical models and surgical guides, and use our targeted patient-specific implants. For industrial applications, they work with us to set up vertical solutions covering the entire cycle from design to production. 10

Our Software Segment 11

Our Software Segment Product Suites Materialise Magics 3D Print Suite - Professionals Focuses on Service Bureaus, both large and small, both external and internal, producing prototypes and small series of end parts. Ensures computer design files can be successfully and much more efficiently 3D printed. Materialise Magics 3D Print Suite - Manufacturing Focuses on OEMs operating 3D printing lines for the serial production of complex end parts and/or customized products. Streamlines the 3D manufacturing process, including managing several materials, machines and customers simultaneously. Materialise Magics Partner Program Partnerships whereby machine vendors, CAD/CAM providers and/or platform providers integrate Materialise solutions into their product offerings. May include parts of both the Professionals and the Manufacturing Suites. These suites include a tailor-made mix of: Build Processors, AMCP, Magics, Streamics, Robots and/or 3-matic. 12

Our Software Segment Machine Software Build Processors Allow for a seamless transfer of data, both telling the 3D printer what to do and allowing the printer to give feedback to the operator. Enable 3D printers to create more complex & betterquality parts. Data on specific jobs can be traced, helping to meet the strict manufacturing requirements of many sectors. Customized. Controller (AMCP) Provides the computing power necessary to operate the demanding quality control systems that are needed in industries such as aerospace and medical. Facilitates the introduction of 3D Printing into highly regulated industries. Key component of quality management systems. Open ecosystem. 13

Our Software Segment Certified Additive Manufacturing Magics Streamics Robot Enables the user to import, repair, and optimize the data of computer design files and get them ready for printing. Ensures computer design files can be successfully 3D printed. Industry standard. Open ecosystem. Provides real-time data regarding printer condition, print job status, and material/shipment flow. Streamlines the otherwise-complex task of managing several materials, machines and customers simultaneously. Customized. Open ecosystem. Automates much of what Magics does, including support for instant quoting. Further streamlines and speeds up the 3D printing production process, reducing manual effort and the possibility of human error. Industry standard. Open ecosystem. 14

Our 3D Medical Segment 15

Our Medical Segment Product Suites Materialise Mimics Innovation Suite Addresses the needs of research institutes, universities and medical device companies. Starting with CT or MRI images, creates a precise 3D replica of patient anatomy in a virtual software environment and enables the design of medical devices (implants, surgical guides) on the anatomy of the patient. Both (parts of) the anatomy as well as the (newly designed) devices can be 3D printed. Materialise Mimics Care Suite Focuses on the needs of hospitals and medical professionals. Same software core as the Innovation Suite, but adapted for precise surgical planning purposes in a hospital setting (both in 2D and 3D); includes optionality to 3D print patient specific medical devices. Materialise Mimics Partner Program Partnerships whereby medical device companies integrate or link Materialise solutions in or with their own product offering. Includes solutions of the Materialise Innovation Suite. These suites include a tailor-made mix of: Mimics, 3-matic, OrthoView, Surgical Planning Devices, and/or Custom Implants. 16

Our Medical Segment Software Mimics 3-matic OrthoView Starting with CT or MRI images, creates a precise 3D replica of patient anatomy in a virtual software environment. This replica can also be 3D printed. Enables surgical pre-planning, minimizing variability in the operating room. Regulatory clearance in US & EU. CE-labelled. Underlying files 3D printable. Starting with a Mimics 3D image, enables the design of medical devices (implants, surgical guides) right on the anatomy of a patient in a virtual software environment. These devices can then be 3D printed. Allows the design of implants that fit the anatomy of a patient. Regulatory clearance in US & EU. CE-labelled. Underlying files 3D printable. Imports 2D x-ray images into a virtual software environment, and allows for the positioning of the templates of suitable prostheses on the image at the correct scale. Enables surgical pre-planning based on more widely available 2D x-rays. Regulatory clearance in US & EU. CE-labelled. Compatible with many PAC systems. 17

Our Medical Segment 3D-Printed Products Surgical Planning Devices Models 3D-printed based on a precise 3D replica of patient anatomy created in Mimics software. Provide exact, rather than approximate, physical representations of patient anatomy, enabling precise surgical preplanning. Unique offering in combination with our front- and back-end software tools. Surgical Planning Devices Surgical Guides 3D-printed based on surgical plans created right on patient anatomy in Mimics & 3-matic. Used by surgeons in the operating room to precisely guide where it is necessary to cut and drill in order to optimally install standard implants. Ensure placement of standard implants, and minimize variability in the operating room. Unique offering in combination with our front- and back-end software tools. Custom Implants Patient-specific orthopedic bone & joint implants, produced through Mobelife. Flagship product: Hip revision implants. Patient-specific titanium implants for cranio-maxillofacial surgeries, produced through OBL. Flagship product: Cranial plates. Provide solutions for complex reconstructive surgeries that precisely fit the anatomy of the patient and respect the physiology of bone. One-of-a-kind. 18

Our Manufacturing Segment 19

Our Manufacturing Segment Services Design & Engineering Consultancy Through 3DP Academy, Co-Creation Lab, and 3DP Scan, works hand-inhand with customers to help them discover what 3D Printing can mean for them and support them in the creation of new products or the transformation of existing ones. Co-develop with the customer, new vertical solutions from design to production. Materialise Manufacturing End Parts Through our Certified Manufacturing Process, offers customers access to a wide-range of 3D printing technologies and materials for the creation of enduse products. Through the web-based i.materialise, manufacturing services are also accessible to smaller businesses and consumers. Materialise Manufacturing Prototypes Offers customers access to a widerange of 3D printing technologies and materials for the creation of prototypes and models to verify designs. Through the web-based Materialise OnSite, prototyping services are accessible 24 hours a day, 7 days a week. 20

Q1 2016 Highlights Total revenue increased 14% to 26,667 keur from prior year in a seasonally slow quarter. Deferred revenue from annual software sales and maintenance contracts increased 1,731 keur from prior year to 13,962 keur. Gross margin expanded to 59.9%. Adjusted EBITDA was 1,135 keur for a 4.3% margin. 21

Consolidated Revenue Q1 2016 Revenue by Segment 40,000 35,000 30,000 25,000 20,000 15,000 10,000 Consolidated Revenue 23,348 26,667 Q1 2015 Q1 2016 Revenue increases in all segments. Continued to execute on strategy to grow contribution of software revenue. 28% Software 40% Medical Manufacturing 32% Q1 2016 Revenue by Product Type 20% Software 40% End Parts Prototyping 40% Continued to execute on strategy to increase end part manufacturing. 22

Consolidated Adjusted EBITDA 1,500 1,200 900 600 300 0-300 Consolidated Adjusted EBITDA -1.2% - 288 4.3% 1,135 Q1 2015 Q1 2016 Q1 2016 consolidated adjusted EBITDA grew from (288) keur to 1,135 keur. Q1 2016 consolidated adjusted EBITDA grew 550 basis points to 4.3%. Improvements reflect: Continued shift of revenue mix to industrial and medical software licenses. Improvement in Manufacturing s gross margin. Moderate increase of operational expenses compared to revenue growth. 23

Software Segment 8,000 7,000 6,000 5,000 4,000 3,000 Revenue 7,431 6,116 Q1 2015 Q1 2016 3,000 2,500 2,000 1,500 1,000 500 0 EBITDA 37.2% 2,765 36.2% 2,215 Q1 2015 Q1 2016 Q1 2016 sales* generated from OEMs increased by 13% from the prior-year period. Steady growth of recurring license revenue, up 25% from Q1 2015. EBITDA grew 25% on 22% revenue growth. *Sales are defined in this presentation as revenue plus deferred revenue. 24

Medical Segment 9,000 8,000 7,000 6,000 5,000 Revenue 8,606 7,848 Q1 2015 Q1 2016 1,000 700 400 100-200 - 500-800 EBITDA -9.5% -6.2% - 530-746 Q1 2015 Q1 2016 Q1 2016 medical software sales increased 4% from Q1 2015. Medical software represented 36% of total medical revenues. Direct sales from complex surgery devices increased 27% from Q1 2015 and represented 15% of total medical segment. Q1 2016 sales from medical collaboration partners increased 12% from Q1 2015. 25

Manufacturing Segment 11,000 10,000 9,000 8,000 7,000 6,000 5,000 Revenue 10,606 9,384 Q1 2015 Q1 2016 300 200 100 0-100 EBITDA 2.4% 257-0.4% (40) Q1 2015 Q1 2016 62% growth in sales of end parts for Q1 2016 over Q1 2015. Number of printers increased to 142 as of March 31, 2016. 26

Income Statement Highlights (in thousands of euros, except where indicated) * Excludes non-controlling interest. Q1 2016 2015 Revenue 26,667 23,348 Cost of sales (10,705) (9,881) Gross profit 15,962 13,467 Research & development expenses (4,372) (4,507) Sales & marketing expenses (8,815) (9,215) General & administrative expenses (5,050) (3,575) Other income/(expenses), net 1,286 1,780 Operating profit/(loss) (989) (2,050) Financial income/(expenses), net (734) 1,472 Share in loss of joint venture (168) (60) Taxes (1,260) (250) Net profit/(loss) (3,151) (888) Diluted EPS* (0.07) (0.02) Diluted weighted average shares (thousands) 47,325 47,170 27

Other Financial Highlights (in thousands of euros) 03/31/2016 12/31/2015 Cash & equivalents 49,435 50,726 Receivables 23,152 22,843 Inventories 5,172 5,387 Payables 8,965 9,967 Total deferred income 18,181 16,601 Total borrowings 20,742 21,089 Total equity 79,028 82,955 Total liabilities and equity 140,452 144,136 (in thousands of euros) Q1 2016 Q1 2015 Capital expenditures 1,590 3,057 Cash flow from operations 1,376 818 28

Strategic Achievements & Goals Strengthening position as backbone of 3D printing industry and leading enabler of 3D printing applications 2015 Achievements 2016 Strategic Priorities Bolstered position in traditional 3D printing market through structured partnerships & direct sales Expanded technology platforms to meet high demands of end part manufacturing Launched framework of build processors Introduced control panels Developed Magics 20 SOFTWARE Continue to execute backbone strategy Further expand direct and indirect sales footprint Continuous innovation of technology platform Successfully switched from perpetual to annual licenses Opened up guide platform Increased sales reach of complex surgery solutions MEDICAL Implement initiatives to drive next stage of growth Launch of Mimics Care Suite Implementation of open guide platform Continued growth of direct and indirect sales of patient-specific implants Began offering metal printing services Increased end parts production Engaged in co-engineering with key players considering 3D printing for end parts MANUFACTURING Continued focus on additive manufacturing of end parts Increase role as incubation center for new vertical applications of 3D printing 29

Fiscal 2016 Guidance Consolidated Revenue 115M to 120M euros Consolidated Adj. EBITDA (1) 7M to 9M euros Deferred Revenue 3M to 4M euros Note: These objectives do not represent budget estimates or projections of any type and have not been prepared by management in the manner budget estimates or projections are prepared. The Company s operational and financial objectives change from time to time based on numerous factors, and the Company s ability to achieve any objective is subject to significant business, economic, regulatory and competitive uncertainties and contingencies, many of which are beyond the control of the Company and its management, and are based upon assumptions with respect to future decisions, which are subject to change. Actual results will vary and those variations may be material. For discussion of some of the important factors that could cause these variations, please see the risk factors described in our annual report on Form 20-F filed with the SEC on April 28, 2016. Nothing in this presentation should be regarded as a representation by any person that these objectives will be achieved and the Company undertakes no duty to update its objectives. (1) Adjusted EBITDA is a non-ifrs financial measure that the Company calculates as net profit plus income taxes, financial expenses (less financial income), depreciation and amortization and stockbased compensation expense. 30

Appendix

Materialise Executive Team Name Title / Business Unit Responsibility Years with Materialise Executive Board Fried Vancraen Founder & Chief Executive Officer 25 Peter Leys Executive Chairman 2 Hilde Ingelaere Executive Vice President, Medical 22 Johan Albrecht Chief Financial Officer Joined mid-2015 Executive Officers Johan Pauwels Executive Vice President, 3D Printing Software 25 Bart Van Der Schueren Chief Technology Officer 20 Wim Michiels Executive Vice President, International 16 Cohesive Executive Operating Team: Average 16+ Years at Materialise 32

APPENDIX Adjusted EBITDA Reconciliation For the three months ended March 31 (in thousands of euros) 2016 2015 Net profit/(loss) (3,151) (888) Income taxes 1,260 250 Financial expense 897 449 Financial income (163) (1,921) Share of loss in a joint venture 168 60 Depreciation & amortization 1,910 1,542 EBITDA 921 (508) Non-recurring IPO expenses 0 0 Non-cash stock-based compensation expenses 214 220 Adjusted EBITDA 1,135 (288) 33