Material Safety Data Sheet NFPA HMIS Personal Protective Equipment 0 Health Hazard Fire Hazard 0 See Section 5. Section. Chemical Product and Company Identification Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym Melatonin SPECTRUM LABORATORY PRODUCTS INC. 4422 S. SAN PEDRO STREET GARDENA, CA 90248 N-Acetyl-5-methoxytryptamine; Melatonine; 5-Methoxy-N-acetyltryptamine; N-(2-(5-Methoxy-H-indol-3-yl)ethyl)acetamide Catalog Number(s). CAS# RTECS TSCA CI# M2095 73-3-4 AC5955000 TSCA 8(b) i nventory: No products were found. Not listed on TSCA (8) Inventory IN CASE OF EMERGENCY CHEMTREC (24hr) 800-424-9300 Page Number: Chemical Name Chemical Family Chemical Formula Supplier Acetamide, N-(2-(5-methoxyindol-3-yl)ethyl)- C3H6N2O2 SPECTRUM LABORATORY PRODUCTS INC. 4422 S. SAN PEDRO STREET GARDENA, CA 90248 CALL (30) 56-8000 Section 2.Composition and Information on Ingredients Name CAS # Exposure Limits TWA (mg/m 3 ) STEL (mg/m 3 ) CEIL (mg/m 3 ) % by Weight ) Melatonin 73-3-4 00 Toxicological Data on Ingredients Section 3. Hazards Identification Potential Acute Health Effects Potential Chronic Health Effects Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. CARCINOGENIC EFFECTS: MUTAGENIC EFFECTS: TERATOGENIC EFFECTS: DEVELOPMENTAL TOXICITY: Repeated or prolonged exposure is not known to aggravate medical condition.
Melatonin Page Number: 2 Section 4. First Aid Measures Eye Contact Skin Contact Serious Skin Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 5 minutes. Get medical attention if irritation occurs. Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Inhalation Serious Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Ingestion Serious Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Section 5. Fire and Explosion Data Flammability of the Product Auto-Ignition Temperature Flash Points Flammable Limits Products of Combustion Fire Hazards in Presence of Various Substances Explosion Hazards in Presence of Various Substances Fire Fighting Media and Instructions Fire Hazards Explosion Hazards May be combustible at high temperature. These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). Slightly flammable to flammable in presence of heat. Risks of explosion of the product in presence of mechanical impact: Risks of explosion of the product in presence of static discharge: SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Material in powder form, capable of creating a dust explosion. As with most organic solids, fire is possible at elevated temperatures Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. Section 6. Accidental Release Measures Small Spill Large Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.
Melatonin Page Number: 3 Section 7. Handling and Storage Precautions Storage Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents. Keep container tightly closed. Keep container in a cool, well-ventilated area. Section 8. Exposure Controls/Personal Protection Engineering Controls Personal Protection Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill Exposure Limits Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Section 9. Physical and Chemical Properties Physical state and appearance Molecular Weight ph (% soln/water) Solid. (Powdered solid.) 232.28 g/mole Odor Taste Color White. Off-white. Boiling Point Melting Point 5 C (239 F) - 9 C. Critical Temperature Specific Gravity Vapor Pressure Vapor Density Volatility Odor Threshold Water/Oil Dist. Coeff. Ionicity (in Water) Dispersion Properties Solubility Section 0. Stability and Data Stability Instability Temperature Conditions of Instability Incompatibility with various substances Corrosivity The product is stable. Excess heat, incompatible materials, dust generation. Reactive with oxidizing agents. Non-corrosive in presence of glass.
Melatonin Page Number: 4 Corrosivity Polymerization Will not occur. Section. Toxicological Information Routes of Entry Toxicity to Animals Chronic Effects on Humans Other Toxic Effects on Humans Toxicity to Animals Chronic Effects on Humans other Toxic Effects on Humans Inhalation. Ingestion. Acute oral toxicity (LD50): 250 mg/kg [Mouse]. Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. May affect genetic material (mutagenic). May cause adverse reproductive effects and birth defects (teratogenic). Human: passes through the placenta. May cause cancer based on animal test data. Acute Potential Health Effects: Skin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: May cause digestive tract irritation abdominal cramps, and anorexia. It may affect the liver (hepatits), urinary system, cardiovascular system (hypotension), behavior/central nervous system (convulsions, drowiness, antianxiety, rigidity, headache, confusion, psychotic disorder, ataxia, change in motor activity) Chronic Potential Health Effects: Ingestion: Prolonged or repeated ingestion may cause abdominal cramps, weight loss, itching hypothermia, and affect the blood (pigmented or nucleated red blood cells, changes in red blood cell count, changes in white blood cell count, changes in serum compositon), brain, liver, cardiovascular system (vasodilation, increase in pulse rate/tachycardia), endocrine system, urinary system, immune system, behavior/centralnervous system (central nervous system depression- see acute ingestion) Section 2. Ecological Information Ecotoxicity BOD5 and COD Products of Biodegradation Toxicity of the Products of Biodegradation the Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The products of degradation are more toxic. Section 3. Disposal Considerations Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Melatonin Page Number: 5 Section 4. Transport Information DOT Classification Not a DOT controlled material (United States). Identification Special Provisions for Transport DOT Section 5. Other Regulatory Information and Pictograms Federal and State Regulations California Proposition 65 Warnings Other Regulations No products were found. California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: No products were found. California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS no. 200-797-7) Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non- Domestic Substance List (NDSL). China: Not listed on National Inventory. Japan: Not listed on National Inventory (ENCS). Korea: Not listed on National Inventory (KECI). Philippines: Listed on National Inventory (PICCS). Australia: Listed on AICS. Other Classifications WHMIS (Canada) Not controlled under WHMIS (Canada). DSCL (EEC) This product is not classified according to the EU regulations. HMIS (U.S.A.) Health Hazard Fire Hazard 0 National Fire Protection Association (U.S.A.) Health 0 Flammability Personal Protection E Specific hazard WHMIS (Canada) DSCL (Europe) TDG (Canada)
Melatonin Page Number: 6 ADR (Europe) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses. Section 6. Other Information MSDS Code References Other Special Considerations M3454 Validated by Sonia Owen on 2/20/2009. Verified by Sonia Owen. Printed 3/6/2009. CALL (30) 56-8000 Notice to Reader All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products, Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.