BD Hypak. Prefilled. Proven. Preferred.

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Prefilled. Proven. Preferred. Prérempli. Prouvé. Préféré. Vorgefüllt. Bewiesen. Bevorzugt. Preriempito. Provato. Preferito. Pre-Lleno. Provado. Preferido. BD Hypak

See your sales soar with BD Hypak prefilled syringes Differentiate your product Demand for the convenience and safety of prefilled delivery systems is growing. The proven quality and efficiency of BD Hypak truly differentiate your product from those in vials. BD Hypak offers many special features that can be customized, allowing you to tailor your product to meet specific end-user needs Expand into new markets Capitalize on a well-known brand, accepted worldwide Provide the ideal vehicle for self-injection and use at alternate sites Deliver medical and clinical benefits Accurate, premeasured dose Faster to use in emergencies than vials Reduced risk of microbial contamination Offer peel-off duplicate labels to reduce potential for medication errors and facilitate patient charting Improve your bottom line BD Hypak requires only a 2% overfill (over the injected dose) vs 18% to 23% overfill for single-dose vials Increase your sales while lowering costs due to: More dose available from the existing drug supply Less drug wasted as overfill BD Hypak is the proven choice by many pharmaceutical companies for vaccines, antithrombotics, biotechnology drugs, and more.

Prefilled syringes are preferred by the healthcare community Physicians, nurses, and pharmacists strongly prefer prefilled syringes over vials/ampules (300 respondents)* Physicians, nurses, and pharmacists cite the benefits of prefilled syringes (254 respondents)* Cost per injection: BD Hypak versus conventional injection Alternate-sites study (US) Hospital study (Europe) BD Hypak prefilled syringe Conventional vial-and-syringe method * Identified in market research conducted by an independent source for BD Pharmaceutical Systems. Data on file. Includes labor and materials costs to prepare and administer a dose, but does not include cost of drugs, as packaged. BD Pharmaceutical Systems. Data on file. Prefilled Disposable s vs Conventional Injection Systems. European Medicoeconomic Analysis. European Hospital Pharmacy. December 1998;4:109-113. In dollars, converted from French francs 3/13/00. Cost per injection ($) Single-dose preparation savings: $0.19 Batch preparation savings: $0.26 Single-dose preparation savings $0.21 BD Hypak

BD Hypak prefilled syringes tailored to meet your needs A complete and ready-to-use injection system Recognized as the global standard Proven system offers a wide range of options to meet specific needs For injection, volume from 0.1 ml to 20 ml For needles, Luers, or BD Luer-Lok (LLA) Sourced from multiple plants worldwide at the highest level of quality Options BD Protectis Rigid Needle Shield (RNS) Custom ceramic printing is available in a wide variety of colors Colored plunger rods Flange extenders and backstops Elastomers Broad spectrum of pharmaceutical elastomer formulations Wide range of latex-free products 0.5 ml 1.0 ml Long 1.0 ml 1.5 ml 2.25 ml 3.0 ml 5.0 ml 10.0 ml 20.0 ml

Associated BD Hypak based products BD SafetyGlide needle Safety without compromise needle-based system meets the new US safety requirements Single-handed activation Needle fits on any Luer or LLA syringe BD Hypoint needle Featuring the gold standard in needles Safe, easy to handle, and tamper-evident BD Protectis NEW Automatic needle-shielding system Offers easy, one-handed activation of unique safety shield after injection with BD Hypak syringe BD Auto-Injector Self-injection that s safe, reliable, and easy to use Reusable injector with unit-of-use cartridges containing a prefilled BD Hypak syringe Hidden, retractable needle helps relieve injection anxiety BD Hypak

BD Hypak SCF packaging for ease and simplicity in processing BD Hypak SCF Sterile, Clean, and ready to Fill Prior to delivery, BD performs all manufacturing and processing up to and including sterilization. Our manufacturing process meets the stringent demands of the pharmaceutical industry. BD Hypak SCF benefits Innovative format allows you to focus on your core product by eliminating component preparation concerns Simplified processing reduces costs and speeds time to market Standardized configuration allows product changes without disrupting your manufacturing process More options for meeting different market needs All future BD Hypak product improvements sourced from multiple plants worldwide will be fully compatible with the process you have chosen

Processing for the pharmaceutical company Processing advantages BD SCF Processing Steps BD SCF (Sterile, Clean, ready to Fill) enables simple and flexible processing Simple three-component system barrel Plunger stopper Plunger rod BD has equipment available for use in stability testing Fill Stopper Inspect Label Assemble Plunger Rod Secondary Package Semiautomated processing Utilizes separate filling and stoppering units Minimal start-up investment for the manufacturer Processes an average of 5,000 syringes per hour Utilizes nested (NSCF) stoppers Automated processing Choice of totally automated filling/ stoppering equipment can process up to 18,000 syringes per hour In-lining of the total process assures consistency and reduces personnel needs Compatible with Isolation/Barrier technology Utilizes bagged (BSCF) stoppers BD Hypak

BD has the services and expertise to support you Sales & Customer Service Marketing Technical Extensive, ongoing market research with manufacturers and end users An understanding of market trends for parenteral delivery systems (eg, safety) Capable of adapting your product to meet regional needs in a global world Quality and Regulatory BD Hypak conforms to US, European, and Japanese pharmacopoeias Drug Master File (DMF) and a Technical Dossier are available for product registration Our regulatory experts are ready to assist you in your dialogues with healthcare authorities Partnering with machine manufacturers to meet all your processing requirements Our Technical Support Team is ready to assist you during any phase of processing Expert project teams are ready to propose innovative solutions to meet your specific drug-delivery needs 1 Becton Drive Franklin Lakes, New Jersey 07417-1886 U.S.A. Telephone: 800.225.3310 For Calls Outside the U.S.: 201.847.4017 Fax: 201.847.4847 www.bd.com/pharmaceuticals Europe: BD S.A. Pharmaceutical Systems 11, rue Aristide Bergés 38800 Le Pont-de-Claix France Tel: (33) 4 76 68 36 36 Fax: (33) 4 76 68 36 21 BD, BD Logo and all other trademarks are the property of Becton, Dickinson and Company. 2000 Printed in USA 11/00 BD 1012