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Research in the field of eating disorders has come a long way in the last few decades, but there is still much to be discovered for improved treatments and the related comorbidities that often accompany eating disorders. McCallum Place is committed to producing quality research that not only adds to the literature, but also benefits patients clinically. We conduct testing on site with participating patients (approximately 75%), and we also partner with external researchers such as Washington University in St. Louis, the University of North Carolina for their Anorexia Nervosa Genetics Initiative (ANGI), and the Residential Eating Disorders Coalition (REDC) to investigate eating disorder pathology and to produce meaningful, relevant research to improve the care of patients suffering from eating disorders both at McCallum Place and other treatment centers at large. McCallum Place has chosen measures that have demonstrated both reliability and validity to assess eating disorder symptomatology and related illnesses over the course of treatment. Our findings are statistically significant at or below a.05 level. What We ve Found: McCallum Place helps patients get better! Between December 12 and 15: Patients had significantly reduced eating disorder thoughts and behaviors Patients had significantly reduced depression and anxiety Patients had significantly improved quality of life Patients with Anorexia Nervosa had significantly higher BMIs, with the majority (86%) discharging in a healthy BMI range after 30 or more days in treatment. Because of the severity of low weight in some of our patients, some needed up to 1 days to be fully weight restored (100% of these patients had a BMI in a healthy range upon discharge) Patients had significantly decreased eating disorder thoughts and behaviors regardless of age or type of eating disorder Patients maintain some significant improvement during the year following discharge

Eating Disorder Examination Questionnaire (EDE-Q) assesses the psychological and behavioral impairments associated with eating disorders, such as restricting food intake, binge eating, eating in secret, and negative feelings about body..5 EDE-Q 3.5-6: Elevated Clinical 3 2.65 1.56-3.90: Clinical Cutoff 2.5 2 0-1.55: Non-Clinical Norm 1.5 N=285 Clinical Impairment Assessment (CIA) measures the severity of impairment associated with eating disorders, such as ability to concentrate, disruptions with social life, and relationships with others. 36 32 33.6 CIA 16-8: Clinical Range 28 2 21.68 0-15: Non-Clinical Range 16 N=28

Beck Inventory II (BDI-II) measures severity of depression. 62 56 50 BDI 29-63: Severe -28: Moderate 38 32 26 1 31.9.02 1-19: Mild 0-13: Minimal N=210 Penn State Worry Questionnaire (PSWQ) assesses various dimensions of worry, such as excessive, general, and uncontrollable worry. PSWQ 76 70 6 58 52 6.25 58.59 60-80: High Worry 0-59: Moderate Worry 16-39: Low Worry 6 0 N=133

World Health Organization Disability Assessment Schedule (WHODAS) assesses disability across six domains, including understanding and communicating, getting around, self-care, getting along with people, life activities (i.e., household, work, and/or school activities), and participation in society. 6 5 WHODAS Ranges from 1-5; clinical norms have yet to be established 3 2.3 2 1.89 1 N=131 Body Mass Index (BMI) in Patients with Anorexia Nervosa BMI 21.2 Healthy BMIs range from 18.5 to 2.9 19 18 17. 17 16 N=316

Eating Disorder Examination Questionnaire Post-Treatment Patients report increased eating disorder symptoms at the 6 month follow up mark, but overall patients maintain the benefits of treatment during the year following discharge from McCallum Place. EDE-Q Scores: through 12 Month Follow Up 3.8 3.6 3. 3.2 3 2.8 2.6 Admit Mean DC Mean 1mo F/U 3mo F/U 6mo F/U 12mo F/U N=53 Clinical Impairment Assessment Post-Treatment Patients maintain the benefits of treatment during the year following discharge from McCallum Place. 36 CIA Scores: through 12 Month Follow Up 3 32 30 28 26 2 22 Admit Mean DC Mean 1mo F/U 3mo F/U 6mo F/U 12mo F/U N=5

Body Mass Index in Patients with Anorexia Nervosa Patients remain in a healthy BMI range during the year following discharge from McCallum Place. 21 BMI in Patients with AN: through 12 Month Follow Up.5 19.5 19 18.5 18 17.5 17 Admit Mean DC Mean 1mo F/U 3mo F/U 6mo F/U 12mo F/U N=36