Ministero della Salute

Ministero della Salute Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti BANDO 2010 GIOVANI RICERCATORI e RICERCA FINALIZZATA Tutte le Sezioni 2320870 2306996 2309719 2312984 2310494 2314291 RODDI New Robotic Platform for Rehabilitation of Children with Pervasive Developmental Disorders and Cognitive Impairments. Multipotent Stem/Progenitor Cells in Human Extrahepatic Biliary Tree: isolation, culturing, differentiation in vitro and in vivo, identification of intracellular pathways modulating proliferation and differentiation and development of strategies for the t EMILIN1 in tumor microenvironment: role in neoplastic growth and lymphatic spread Role of morgana/chp 1 in myeloproliferative disorders mir 221&222/miR 126&126* interconnected networks: novel molecular markers and potential therapeutic values in melanoma. Role of circulating and tissutal markers of low grade chronic inflammation for defining the clinical phenotype of complicated obesity CARLO BESTA CLI ORD Biobehavioral and 4 351.158 222.900 Behavioral Processes Marche ORD Digestive, Kidney 4,5 210.900 195.400 and Urological Systems C.R.O. AVIANO ORD Oncology 1 Basic 4,5 295.000 272.600 Piemonte ORD Oncology 1 Basic 4,5 300.000 276.700 Istituto Superiore di Sanita' ORD Oncology 1 Basic 4,5 365.500 336.600 MAUGERI CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 4,5 400.000 254.300 Pagina 1 di 332

2318823 Toward Chronic Lymphocytic Leukemia (CLL): dissecting the role of genetic lesions in Monoclonal B cell Lymphocytosis (MBL) through a genome wide sequencing approach SAN RAFFAELE MONTE TABOR ORD Oncology 1 Basic 4,5 450.000 412.800 2309622 Definition of mechanisms controlling processing and secretion of IL 1beta in health and autoinflammatory diseases, search for novel therapeutic strategies IRCCS AOU San Martino IST (Genova) ORD Immunology 4,5 600.000 481.700 2317594 2320280 2311657 NEW GENETIC LESIONS CHARACTERIZING HIGH RISK CHRONIC LYMPHOCYTIC LEUKEMIA: CLINICAL AND FUNCTIONAL IMPLICATIONS Characterization of the histone deacetylase SIRT1 in human Non Hodgkin Lymphomas and lymph nodes. Recovery of cholinergic neurotransmission dysfunction in DYT1 dystonia Piemonte EST Oncology 2 4,5 600.000 500.000 ARCISPEDALE ORD Oncology 1 Basic 5 200.000 175.600 SANTA LUCIA ORD Brain Disorders and 5 370.000 320.800 2310201 Plasma microrna profiling as first line screening test for lung cancer detection: a prospective study ISTITUTO TUMORI MILANO CLI ORD Oncology 2 5 390.000 358.400 2319316 High density EEG as a tool for localizing the epileptogenic zone in extratemporal refractory focal epilepsy: a validation study by means of Stereo EEG and post surgical outcome evaluation Lombardia CLI EST Brain Disorders and 5 393.000 306.600 2319050 Gene therapy for thalassemia: preclinical studies of efficacy and safety SAN RAFFAELE MONTE TABOR ORD Genes, Genomes 5 500.000 432.500 and Genetics 2310438 PROTECTIVE AND DANGEROUS IMMUNE RESPONSES DURING HIV 1 INFECTION OSPEDALE BAMBINO GESU' CLI EST AIDS and Related 5 515.000 401.100 Research Pagina 2 di 332

2312222 2313979 2318269 The role of hypoxia in regulating micrornas and target genes in cancer biology: identification of new therapeutic targets strategy for developing rationale combinations of molecularly targeted agents in primary refractory Hodgkin lymphoma Exploiting immune cross reactivity to influenza viral antigens for successful pre pandemic vaccines. Istituto Superiore di Sanita' ORD Oncology 1 Basic 5 522.500 451.800 Piemonte CLI ORD Oncology 2 5 550.000 500.000 Istituto Superiore di Sanita' ORD Immunology 5 579.700 454.800 2312785 Therapeutic potential and safety assessment of induced dopaminergic neuronal (idan) cells directly reprogrammed from adult skin fibroblasts SAN RAFFAELE MONTE TABOR ORD Molecular, Cellular, 5 585.000 454.800 and Developmental 2309484 2305041 2316156 2310888 2319722 STUDIES ON THE INVOLVEMENT OF GENETIC, EPIGENETIC AND ENVRINOMENTALFACTORS IN THE PATHOGENESIS OF CONGENITAL HYPOTHYROIDISM.NOVEL PERSPECTIVES FOR THE MANAGEMENT OF A LARGELY UNEXPLAINED DISORDER Impaired Angiogenesis: a Novel Player and Potential Therapeutic Target in Muscular Dystrophy Immunotherapy with dendritic cells loaded with cancer stem like cells: a phase I study in glioblastoma TUMOR ASSOCIATED MACROPHAGES: NEW MARKERS FOR MOLECULAR TARGETING Italian Network for autosomal dominant Alzheimer s disease and frontotemporal lobar degeneration AUXOLOGICO ORD Endocrinology, Metabolism, Nutrition and Reproductive 5 590.000 454.800 Istituto Superiore di Sanita' ORD Musculoskeletal, 5 598.800 454.800 Oral and Skin CARLO BESTA CLI ORD Oncology 2 5 599.000 320.800 HUMANITAS ORD Oncology 1 Basic 5 600.000 454.800 FATEBENEFRATELLI ORD Brain Disorders and 5,25 600.000 454.800 Pagina 3 di 332

2310538 Building a state of the art whole room indirect calorimeter, a tool to accurately investigate the role of energy expenditure and substrate oxidation in endocrine and metabolic disorders Toscana ORD Endocrinology, Metabolism, Nutrition and Reproductive 5,25 600.000 454.800 2314703 2310812 Role of Nuclear Receptor Coactivator PGC1 beta in the Intestinal Epithelium Effect of supervised exercise training on risk of fractures in subjects with type 2 diabetes ONCOLOGICO DI BARI ORD Endocrinology, Metabolism, Nutrition and Reproductive 5,25 600.000 454.800 Lazio CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 5,5 180.000 164.200 2310935 Oculo auriculo vertebral spectrum: use of an integrated high throughput platform to identify the disease causing genes and implications in clinical diagnostics CASA SOLLIEVO SOFFERENZA ORD Genes, Genomes 5,5 250.000 215.000 and Genetics 2320172 Assessment of short and long term risk benefit profile of biologics through healthcare database network in Italy Sicilia CLI ORD Population 5,5 300.000 272.900 and Epidemiology 2313899 Biomolecular and functional analysis of pathogenetic mechanisms of neuropathic pain in genetic and acquired small fibre neuropathies. Istituto Scienze Neurologiche ORD Molecular, Cellular, 5,5 422.000 362.200 and Developmental 2318508 Modulation of metabolic mechanisms in muscle loss disorders: involvement of autophagy and apoptosis. SAN RAFFAELE PISANA ORD Musculoskeletal, 5,5 450.000 386.600 Oral and Skin 2311584 Thrombolysis in Minor Stroke Emilia Romagna CLI ORD Brain Disorders and 5,5 500.000 245.400 Pagina 4 di 332

2318372 2308334 Novel surface and intracellular targets for tailored nanotechnology based drug delivery in colorectal cancer NEW THERAPEUTICS AND IMMUNOGENS GENERATED BY INCORPORATING SHORT RNAs AND PROTEIN ANTIGENS IN EXOSOMES SDN EST Oncology 1 Basic 5,5 530.000 410.000 Istituto Superiore di Sanita' ORD Bioengineering 5,5 588.000 451.500 and Technologies 2318290 Volatile anesthetics to reduce mortality in cardiac surgery. A multicentre randomized controlled study. SAN RAFFAELE MONTE TABOR CLI ORD Surgical, Biomedical Imaging, and Bioengineering 5,5 600.000 500.000 2314356 2308451 IDENTIFICATION OF GENES FOR RARE DEVELOPMENTAL DISORDERS BY NEXT GENERATION SEQUENCING The Renal Damage Risk Study in children with Vesico Ureteral Reflux grade III to V GASLINI ORD Genes, Genomes 5,5 600.000 451.500 and Genetics Emilia Romagna CLI ORD Digestive, Kidney 5,5 600.000 500.000 and Urological Systems 2319394 A multidisciplinary study to investigate the molecular bases of hereditary tubulointerstitial nephritis SAN RAFFAELE MONTE TABOR ORD Digestive, Kidney 5,5 600.000 451.500 and Urological Systems 2304056 2315840 2317761 Neuropsychological, neurofunctional and epigenetic effects of structured group patient education in type 2 diabetes. Alternative splicing as a tool to develop novel diagnostic and therapeutic approaches to control cancer growth. TRANSLATING MELANOMA EPIGENETICS IN THE CLINICAL SETTING OF COMBINED CHEMO IMMUNOTHERAPIES Piemonte CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 5,75 150.000 150.000 MAUGERI ORD Oncology 1 Basic 5,75 600.000 (2) Toscana ORD Oncology 2 5,9 450.000 386.600 Pagina 5 di 332

2319274 2310674 2317822 2300447 2312924 2321718 2310832 In vivo confocal microscopy of corneal nerves as a novel diagnostic tool in peripheral neuropathies: correlation with skin biopsy, neurophysiology and clinical findings. Standardizing tissue handling in pre analytical procedures: technological, environmentally safe innovation in solid tumour processing. "Epigenetic mechanisms in the control of viral transcription/replication in chronic HBV patients antiviral treatments: an integrated approach to the new biomarkers identification and rational clinical decisions. CANDIDATE PREDICTORS OF GLUCOCORTICOID RESPONSE IN CHILDREN WITH INFLAMMATORY BOWEL DISEASE Neuroinflammation and synaptic function: an electrophysiological analysis in experimental multiple sclerosis Cognitive efficiency and functional connectivity across the lifespan. Is there a signature of abnormal cognitive decline? Role of TNF related apoptosis inducing ligand (TRAIL) in diabetes mellitus and metabolic syndrome Lombardia CLI ORD Brain Disorders and 6 150.000 150.000 Piemonte CLI COF Healthcare Delivery 6 150.000 150.000 and Methodologies MAGGIORE ORD Digestive, Kidney 6 150.200 150.000 and Urological Systems BURLO GAROFALO CLI ORD Digestive, Kidney 6 225.000 193.300 and Urological Systems Umbria ORD Brain Disorders and 6 230.000 197.400 S.CAMILLO ORD Brain Disorders and 6 280.000 197.400 BURLO GAROFALO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 6 290.000 249.200 2315970 Nurr1 puts a dampener on inflammation: a link Piemonte ORD Brain Disorders and 6 292.600 251.200 between Nurr1 deregulation and Multiple Sclerosis. 2321465 RH Project: Advanced Serological and Molecular Investigation for the RhD Variants Definition Lazio ORD Cell Biology 6 300.000 211.600 Pagina 6 di 332

2319328 Transcranial direct current stimulation in the treatment of dyslexia: a randomized double blind study OSPEDALE BAMBINO GESU' ORD Brain Disorders and 6 303.000 260.400 2321151 PHASE I/II TRIAL OF NOGA GUIDED ENDOCAVITARY INJECTION OF BONE MARROW DERIVED CD133+ CELLS IN ISCHEMIC REFRACTORY CARDIOMYOPATHY (RECARDIO TRIAL) MONZINO CLI ORD Cardiovascular and 6 346.500 296.900 Respiratory 2316961 Molecular mechanisms underlying the skin inflammation triggered by Epidermal Growth Factor inhibitors and search for molecular targets for its correction ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Musculoskeletal, 6 350.000 247.200 Oral and Skin 2307403 Congenital anomalies of the kidney and urinary tract (CAKUT): definition of genetic and structural backgrounds based on high throughput innovative approaches. GASLINI EST Digestive, Kidney 6 355.000 244.100 and Urological Systems 2306232 Identification and functional validation of microrna biomarkers in lung cancer ISTITUTO TUMORI MILANO EST Oncology 2 6 396.000 271.500 2309531 Perivascular adipose tissue mirnas: links between insulin resistance in type 2 diabetes and vascular disease ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Endocrinology, Metabolism, Nutrition and Reproductive 6 400.000 343.700 2319511 2314711 Insulin resistance and cancer:new strategies of intervention involving the insulin receptor isoform A THE ITALIAN REGISTRY FOR MYOTONIC DYSTROPHIES Sicilia ORD Endocrinology, Metabolism, Nutrition and Reproductive 6 400.000 343.700 SAN DONATO CLI ORD Population 6 450.000 193.300 and Epidemiology Pagina 7 di 332

2314035 2309921 2318367 2317808 2314610 2305199 Mechanisms of neurodegeneration and phenotypic heterogeneity in inherited prion diseases: physiopathological involvement of prion proteins in membrane trafficking and signaling IS DES ACYL GHRELIN THE KEY MEDIATOR OF KETOGENIC DIET? Biomarkers and functional imaging guided treatment decision making in recurrent prostate cancer. Improving balance through gravity cues embedded in free falling target Relevance of the CD4+ T lymphocytes and synoviocytes cross talk in the pathogenesis of human rheumatoid arthritis and juvenile idiopathic arthritis diseases. Autophagy in the immune response against Mycobacterium tuberculosis: identification of novel rapamycin regulated host targets to improve BCG vaccine immunogenicity. Lombardia ORD Brain Disorders and 6 450.000 318.300 Emilia Romagna ORD Brain Disorders and 6 470.000 332.500 Toscana CLI EST Oncology 2 6 470.000 322.300 SANTA LUCIA ORD Biobehavioral and 6 477.330 337.600 Behavioral Processes Toscana ORD Immunology 6 480.000 339.600 Istituto Superiore di Sanita' EST Infectious Diseases 6 500.000 343.700 and Microbiology 2318330 Epigenetic drugs for human diabetic foot ulcer treatment ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Musculoskeletal, 6 550.000 372.100 Oral and Skin 2312620 IL 6 related inflammation signatures as a predictive marker of recurrence in liver cancer patients ISTITUTO TUMORI MILANO CLI ORD Oncology 2 6 568.800 387.300 2312912 And yet they MOve: immobile patients re enter the physical world through embodiment in avatar or robot surrogates SANTA LUCIA ORD Biobehavioral and 6 588.500 372.100 Behavioral Processes Pagina 8 di 332

2303119 B7.1 on podocytes: a new therapeutic target for diabetic nephropathy SAN RAFFAELE MONTE TABOR ORD Digestive, Kidney 6 590.000 372.100 and Urological Systems 2312059 Separation anxiety, CO2 Hypersensitivity and Panic: Epigenetic Mechanisms in Response to Adversities in Animal and Man SAN RAFFAELE MONTE TABOR ORD Population 6 597.000 372.100 and Epidemiology 2311484 Repetitive TMS modulation of the default mode network to clarify the pathophysiology of Alzheimer s disease and prompt a new therapeutic perspective SANTA LUCIA CLI ORD Brain Disorders and 6 599.500 418.800 2312048 THE IRON INFLAMMATION LIPID CONNECTION REVEALED BY HEPCIDIN REGULATION STUDIES: RELEVANCE FOR THE CORRESPONDING CLINICAL DISORDERS SAN RAFFAELE MONTE TABOR ORD Vascular and 6 600.000 372.100 Hematology 2305128 FSHD muscular dystrophy: molecular pathogenesis and prospects for therapy. SAN RAFFAELE MONTE TABOR ORD Genes, Genomes 6 600.000 372.100 and Genetics 2316780 2318394 2306943 Humanized tumor mice: a new model that improves translational biomedical research to develop new personalized therapies in ovarian cancer. Autosomal Recessive Juvenile Parkinsonism (ARJP) caused by mutation in the PARK2 gene: Identification of the molecular mechanisms by which parkin can modify GluK2 activity and investigation of GluK2 as new target for a neuroprotective therapy Development and preclinical validation of a nanotechnological platform that targets the minimal residual disease (MRD) in Cancer PASCALE ORD Oncology 1 Basic 6 600.000 372.100 AUXOLOGICO ORD Brain Disorders and 6 600.000 451.200 Calabria ORD Oncology 2 6 600.000 372.100 Pagina 9 di 332

2321362 Phenotyping COPD patients and assessing disease severity by means of a standardized model Toscana CLI ORD Cardiovascular and 6,25 150.000 150.000 Respiratory 2313809 MECHANISMS OF VASCULAR DYSFUNCTION IN OBESITY RELATED METABOLIC SYNDROME. Lazio CLI ORD Vascular and 6,25 257.000 154.700 Hematology 2311148 2316198 2306756 2306432 The use of OXT as adjunctive therapy for the treatment of schizophrenia: a randomized, double blind trial PATHWAYS OF COAGULATION AND PLATELET ACTIVATION IN FLOWING BLOOD: NEW PERSPECTIVES IN THE MANAGEMENT OF ANTITHROMBOTIC THERAPY MitoCure: developing treatments for mitochondrial diseases Generation and characterization of an anticd56 IL15 immunocytokine for functional reconstitution of NK cells in HIV infection FATEBENEFRATELLI CLI ORD Biobehavioral and 6,25 500.000 428.900 Behavioral Processes C.R.O. AVIANO EST Vascular and 6,25 525.000 359.900 Hematology CARLO BESTA ORD Genes, Genomes 6,25 530.000 451.200 and Genetics Istituto Superiore di Sanita' ORD AIDS and Related 6,25 557.000 451.200 Research 2312522 Amyotrophic lateral sclerosis (ALS) swine models: production and characterization Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Brain Disorders and 6,25 560.000 451.200 2311329 2318728 Dissection of the immune response to human cytomegalovirus glycoprotein complexes: perspective for the development of a candidate subunit vaccine Mechanisms of diabetes resolution after bariatric surgery: role of the gut SAN MATTEO EST Immunology 6,33 445.000 305.100 Toscana ORD Endocrinology, Metabolism, Nutrition and Reproductive 6,5 207.000 Pagina 10 di 332

2319806 CAPNAF FD. A Computer Assisted Procedure for Nasal Air Flow assessment with modern Fluid Dynamics techniques. applications: individual surgical planning of nasal breathing difficulties treatment aimed at optimizing surgical procedures towards max Lombardia CLI ORD Surgical, Biomedical Imaging, and Bioengineering 6,5 220.000 150.000 2310623 2315477 2310622 2317029 2309849 A PERSONALIZED MEDICAL APPROACH TO TREAT BACTERIAL INFECTIONS IN PATIENTS WITH LIVER CIRRHOSIS. Investigation on the sensitivity of dorsal raphe serotonergic neurons to hypercapnic stimuli in a transgenic mouse model of Sudden Infant Death Syndrome (SIDS) characterised by selective alteration of serotonergic neuron autoinhibition. Search for genetic risk factors in sporadic Amyotrophic Lateral Sclerosis by exome sequencing in patients with a distinct phenotype. INTEGRATED ''OMIC'' APPROACH TO EXPLORE MOLECULAR PATHOGENESIS AND CLINICAL HETEROGENEITY IN FACIO SCAPULO HUMERAL MUSCULAR DYSTROPHY Genotype phenotype characterization of the pathogenetic expansion of the C9ORF72 gene in a large series of Italian familial and sporadic ALS patients Emilia Romagna CLI ORD Digestive, Kidney 6,5 225.000 192.700 and Urological Systems Toscana ORD Molecular, Cellular, 6,5 235.000 and Developmental SAN RAFFAELE PISANA ORD Brain Disorders and 6,5 240.000 STELLA MARIS ORD Musculoskeletal, 6,5 271.700 232.300 Oral and Skin Piemonte CLI ORD Brain Disorders and 6,5 296.000 253.700 2315681 Assessment of safety parameters in cultured mesenchymal stromal cells for use in regenerative medicine. Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary 6,5 300.000 256.700 (5) 2304833 Novel markers based on autophagy proteins in Parkinson's disease NEUROMED CLI ORD Brain Disorders and 6,5 300.000 256.700 Pagina 11 di 332

2315964 2309229 2306851 The ubiquintin editing enzyme A20 (TNFAIP3) as a peacekeeper in inflammation and immunity: a link between TNFAIP3 deregulation and Multiple Sclerosis Spinal Muscular Atrophy with Respiratory Distress (SMARD1): gene therapy as novel therapeutic approach Genetics of Hearing loss: from basic research to clinical applications Piemonte ORD Brain Disorders and 6,5 306.800 262.800 MAGGIORE ORD Genes, Genomes 6,5 315.000 269.900 and Genetics BURLO GAROFALO CLI ORD Genes, Genomes 6,5 327.000 221.200 and Genetics 2319387 Impact of lincrnas on high serous ovarian cancer C.R.O. AVIANO ORD Oncology 1 Basic 6,5 350.000 299.400 2312442 2309299 2319059 2311782 2312954 The Restless Mind: Default Mode Of Operation Or Risk Factor For Health? Liver targeted cell therapy: applications to experimental Glycogen Storage Disease type 1a Preparatory, response related, outcomeevaluation and predictive components of attentional orienting in right brain damage: clues for diagnosis and rehabilitation Neural and behavioural recovery based on Rho GTPases modulation in a mouse model of Rett syndrome Development of new experimental models for intellectual disabilities syndromes studying IL1RAPL1 function in synapse formation SANTA LUCIA ORD Biobehavioral and 6,5 373.068 319.700 Behavioral Processes GASLINI ORD Genes, Genomes 6,5 385.000 and Genetics SANTA LUCIA CLI EST Biobehavioral and 6,5 400.000 274.000 Behavioral Processes Istituto Superiore di Sanita' ORD Brain Disorders and 6,5 407.000 CARLO BESTA ORD Molecular, Cellular, 6,5 430.000 and Developmental 2312197 DRUG TRANSPORTERS AND RESISTANCE TO TREATMENT OF OVARIAN CARCINOMA ISTITUTO TUMORI MILANO ORD Oncology 2 6,5 463.100 Pagina 12 di 332

2312341 2319033 Identification and validation of new therapeutic targets in Acute Myeloid Leukaemia Role of the Wnt/beta catenin pathway in orchestrating epigenetic events in Cancer Stem Cells I.E.O. ORD Oncology 1 Basic 6,5 490.000 Toscana ORD Genes, Genomes 6,5 500.000 428.300 and Genetics 2315953 Regulation of mitotic transitions I.E.O. ORD Cell Biology 6,5 518.000 2305605 Mechanisms of aggregation and toxicity of tau protein in Alzheimer's disease IRCCS AOU San Martino IST (Genova) EST Molecular, Cellular, 6,5 520.000 356.300 and Developmental 2314699 Molecular regulation of the redox switch in inflamed skeletal muscle as a novel target to implement muscle regeneration and limit fibrosis in immune mediated myositis SAN RAFFAELE MONTE TABOR ORD Musculoskeletal, 6,5 524.000 Oral and Skin 2309469 Structural genomics/proteomics and solution characterization of proteins of biomedical interest: development of a comprehensive facility, application to therapeutic monoclonal antibodies quality control, and to the fibrin(ogen) integrins cell matrix inter IRCCS AOU San Martino IST (Genova) ORD Biological Chemistry and Macromolecular Biophysics 6,5 534.500 2309704 Targeting drug resistance in Ovarian Cancer C.R.O. AVIANO EST Oncology 2 6,5 540.000 370.500 2316010 P2X7 receptor/mmp9 pathway in thrombosis and atherosclerotic plaque destabilization: exploring the possibility to modulate carotid plaque progression SAN RAFFAELE MONTE TABOR EST Vascular and 6,5 548.800 376.600 Hematology Pagina 13 di 332

2319060 A phase I II clinical trial with central memory donor T cells expressing a suicide gene in the context of haploidentical hematopoietic stem cell transplantation for the treatment of chemoresistant acute leukemia. SAN RAFFAELE MONTE TABOR ORD Oncology 2 6,5 550.000 2320533 Production and characterization of clinical grade stem cell derived conditioned medium for treatment of ischemic heart disease. SAN MATTEO ORD Cardiovascular and 6,5 569.000 450.600 Respiratory 2314794 Pancreas transplantation in type 1 diabetic patients revealed a potential novel stem cell based mechanism that revert diabetic enteropathy SAN RAFFAELE MONTE TABOR CLI ORD Digestive, Kidney 6,5 580.000 497.300 and Urological Systems 2312272 2313609 2306317 2312693 The role of DNA repetitive elements mobilization in DMD pathogenesis, progression and treatment BCR ABL specific T cell Infusion for the Treatment of Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Pathogenesis, diagnosis and course of familial and sporadic Alzheimer s disease and Frontotemporal Lobar Degeneration: epigenetics and proteomics as new tools for disease mechanisms and biomarker discovery Role of HMGB1 redox state in cardiac tissue regeneration and cardiac progenitor cell function SANTA LUCIA ORD Genes, Genomes 6,5 585.200 and Genetics Emilia Romagna CLI ORD Oncology 2 6,5 591.000 497.300 MAGGIORE ORD Brain Disorders and 6,5 599.886 MONZINO ORD Cardiovascular and 6,5 599.980 450.600 Respiratory 2320871 Tipping the balance between adaptive/maladaptive endoplasmic reticulum stress responses to counter degenerative and storage diseases SAN RAFFAELE MONTE TABOR ORD Cell Biology 6,5 600.000 2305564 ALZHEIMER'S DISEASE LYSOSOMAL ENZYMES: NEW DIAGNOSTIC AND THERAPEUTIC TOOLS Umbria ORD Brain Disorders and 6,5 600.000 Pagina 14 di 332

2313220 Mapping progressive neurodegeneration in amyotrophic lateral sclerosis (ALS): a multiparametric study combining clinical, cognitive, genetic, and neuroimaging assessment to identify predictors of ALS evolution SAN RAFFAELE MONTE TABOR CLI ORD Brain Disorders and 6,5 600.000 497.300 2316644 2315414 2320491 2305957 Characterization of human amniotic mesenchymal stem cells (ha MSCs) isolated from obese women at delivery to identify gene or protein alterations predisposing the newborn to obesity. mtor dependent oscillatory metabolic switch controlling self immune tolerance Development of new IVD CE molecular diagnostic tests for the detection of epigenetic defects involved in human disease Enhancement of models for identification of patients with potential benefit from chronic care case/disease management programs. SDN ORD Endocrinology, Metabolism, Nutrition and Reproductive 6,75 350.000 SANTA LUCIA EST Immunology 6,75 570.000 390.800 MAGGIORE COF Genes, Genomes 7 62.000 (1) and Genetics Emilia Romagna CLI EST Healthcare Delivery 7 200.000 150.140 and Methodologies 2321065 Dissection of metabolic pathways involved in therapeutic plasticity of mesenchymal stem cells IRCCS AOU San Martino IST (Genova) ORD Immunology 7 205.000 2310331 Towards a functional classification of human melanoma: dissecting the altered intracellular signaling profile by phosphoproteomics approaches. ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 7 234.300 2321454 The role of IG20, a novel human gene, and its potential use as therapeutic target in the anaplastic thyroid cancer. Toscana ORD Endocrinology, Metabolism, Nutrition and Reproductive 7 250.000 200.740 Pagina 15 di 332

2309954 2315043 2301676 2318689 2321017 2314540 Reorganization of cortical function after surgery for lesional epilepsy in children Adoptive immunotherapy for the prevention of Hepatitis C Virus (HCV) recurrence after liver transplantation The effects of diabetic autonomic neuropathy on post ischemic bone marrow mobilization of endothelial progenitor cells. A translational study focusing on the role of Sirtuin 1 Extracorporeal Life Support in Acute Respiratory Distress Syndrome (ELSA) Adipose Derived Stem Cells (ADSCs) in Suspension: Phenotyping, Differentiation and Engineering for Cranial Vault Reconstruction. Epidrugs and cardiac differentiation: relevance for the 22q11.2 deletion syndrome Toscana CLI ORD Brain Disorders and 7 250.000 200.740 Sicilia ORD Infectious Diseases 7 270.000 and Microbiology Veneto ORD Vascular and 7 270.000 216.940 Hematology Lombardia CLI ORD Cardiovascular and 7 300.000 241.340 Respiratory Sicilia ORD Surgical, Biomedical Imaging, and Bioengineering 7 303.439 244.340 NEUROMED ORD Cardiovascular and 7 307.200 Respiratory 2306205 Noncoding RNAs and cancer IRCCS AOU San Martino IST (Genova) EST Oncology 1 Basic 7 311.300 164.140 2316197 HPV INFECTION AND DISEASE IN IMMUNOSUPRESSED MALES AND FEMALES: PREVALENCE ANDVIRO IMMUNOLOGICAL DETERMINANTS OF ORGAN DAMAGE IRCCS AOU San Martino IST (Genova) EST Immunology 7 315.000 166.140 2315413 2308303 Inflammation and oxidative stress in preeclampsia: role of the maternal endothelium and of the placenta potential role in early markers development A translational approach to restrain local recurrence in early breast cancer patients Lombardia ORD Biology of 7 322.000 Development and Aging C.R.O. AVIANO ORD Oncology 1 Basic 7 340.000 Pagina 16 di 332

2320779 2309607 2310098 Role of peripheral Schwann cells and muscle in the regeneration of degenerated nerve terminals at the neuromuscular junction. Skeletal muscle in Spinal and Bulbar Muscular Atrophy (SBMA): therapeutic target and delivery route for potential treatments Mutations in ANKRD26 cause a novel inherited thrombocytopenia at risk of developing acute leukemia: dissecting the clinical and molecular consequences of ANKRD26 mutations to better understand the mechanisms of both thrombocytopenia and leukemia Veneto ORD Brain Disorders and 7 350.000 281.940 Veneto ORD Brain Disorders and 7 350.000 SAN MATTEO CLI ORD Genes, Genomes 7 350.000 281.940 and Genetics 2319439 Dysregulated RNA metabolism in multiple myeloma. SAN RAFFAELE MONTE TABOR ORD Oncology 1 Basic 7 350.000 2312580 The ECM molecule MULTIMEIN2 as a potential therapeutic tool to hamper tumor angiogenesis and tumor growth. C.R.O. AVIANO EST Oncology 1 Basic 7 350.000 184.440 2316392 New nuclear genes responsible for mitochondrial disorders: identification by high throughput exome sequencing and functional characterization of the corresponding proteins CARLO BESTA ORD Genes, Genomes 7 378.000 304.340 and Genetics 2318827 2314857 2310869 Microvescicles (MVs) in human Hepatocellular carcinoma (HCC): Potential for diagnostic and therapeutic applications. CCL2/CCR2 BLOCKING: MOLECULAR INSIGHTS INTO A POTENTIAL THERAPEUTIC STRATEGY AGAINST HIV REPLICATION Overcoming the postmitotic state of terminally differentiated cells in favor of regenerative medicine Abruzzo EST Oncology 1 Basic 7 385.000 202.740 Istituto Superiore di Sanita' ORD AIDS and Related 7 390.000 Research Istituto Superiore di Sanita' EST Musculoskeletal, 7 390.000 205.740 Oral and Skin Pagina 17 di 332

2310860 2312868 2314972 Cytokines as biomarkers of disease and therapeutic targets in laminopathies Role of ATM kinase in ErbB2 signaling: a novel therapeutic target to hit ErbB2 positive breast cancer stem cells? Brain and cognitive dynamics of multiple object processing in normal aging, MCI and Alzheimer disease RIZZOLI ORD Biology of 7 400.000 Development and Aging SANTA LUCIA ORD Oncology 2 7 400.000 322.540 FATEBENEFRATELLI ORD Biobehavioral and 7 450.000 362.240 Behavioral Processes 2320721 Interaction between genetic and epigenetic variation of BDNF on cognition, brain activity and risk for schizophrenia CASA SOLLIEVO SOFFERENZA ORD Brain Disorders and 7 450.000 2312483 2304834 2313174 PRECLINICAL DEVELOPMENT OF THERAPEUTIC, ANTI BETA GLUCAN ANTIBODIES FOR UNIVERSAL PROTECTION AGAINST FUNGAL PATHOGENS Idiopathic epilepsy: search for new mutations in HCN ion channels Brain plasticity in Alzheimer Disease and Mild Cognitive Impairment. Functional, structural and neuropsychological effects of a computer based cognitive treatment Istituto Superiore di Sanita' ORD Infectious Diseases 7 455.001 and Microbiology CARLO BESTA ORD Brain Disorders and 7 460.000 370.340 SANTA LUCIA CLI ORD Brain Disorders and 7 465.000 245.340 2318512 Role of influenza virus infection in the etiopathogenesis of diabetes Istituto Zooprofilattico Sperimentale delle Venezie EST Infectious Diseases 7 470.000 248.440 and Microbiology 2317597 Identification of common biological pathways in Rett patients mutated in MECP2, CDKL5 and FOXG1. Toscana EST Molecular, Cellular, 7 470.000 248.440 and Developmental Pagina 18 di 332

2318561 Nerve Growth Factor eye drops as a novel treatment for vision loss in patients with Retinitis Pigmentosa: from preclinical to clinical Phase II trial. SAN RAFFAELE MONTE TABOR CLI COF Brain Disorders and 7 475.000 334.740 2305526 TArgeted Multistage vector (MSV) for the DIagnosis and treatment of Solid tumors Veneto EST Bioengineering 7 478.000 252.540 and Technologies 2317709 Improving strategies for preventing pertussis in infants OSPEDALE BAMBINO GESU' CLI ORD Infectious Diseases 7 480.000 386.540 and Microbiology 2309790 Pemphigus vulgaris as a paradigm of autoantibodymediated organ specific autoimmune disorder: DERMOPATICO ISTITUTO pathophysiology and novel tools for diagnosis and DELL'IMMACOLATA therapy EST Musculoskeletal, 7 480.000 253.540 Oral and Skin 2314855 Mitochondrial targeting in LRRK2 associated parkinsonism (PARK8) SANTA LUCIA ORD Brain Disorders and 7 495.000 2317018 To unravel the molecular basis of neurodevelopmental disorders CASA SOLLIEVO SOFFERENZA ORD Genes, Genomes 7 500.000 and Genetics 2310803 2308270 2319113 2314890 Enhanced cell proliferation for muscle repair and regenerative medicine Interleukin 27 in the control of pediatric acute leukemia cell growth in NOD/SCID/Il2rg / mice with human immune system GRID based System for the Evaluation of the effects of Cognitive Rehabilitation in Patients with Alzheimer s Disease and Parkinsons Disease SALUTE CKD (SALt lowering by Urine sodium self measurement Trial in Chronic Kidney DiseasE) Istituto Superiore di Sanita' ORD Musculoskeletal, 7 507.778 Oral and Skin GASLINI EST Immunology 7 520.000 274.840 SAN RAFFAELE PISANA CLI ORD Brain Disorders and 7 540.000 241.340 Calabria CLI ORD Risk, Prevention 7 550.000 443.340 and Health Behavior Pagina 19 di 332

2307975 2313988 2318448 2315888 2318713 2315788 Micro RNAs regulated by the proto oncogene Pbx1 as therapeutic targets to induce differentiation of cancer cells Peptides from lactoferrin as new therapeutic agents against Influenza virus infection Towards intervertebral disc regeneration: mesenchymal stem/stromal cells with a novel bioactive hydrogel based approach. Dissecting the role of plasmacytoid dendritic cells in the progression of cutaneous melanoma Investigating the molecular mechanisms leading to genome instability in tumours: analysis of role of the replication stress response and its potential for early diagnosis and target therapy of cancer Role of APOBEC1 in the initiation and progression of cancer HUMANITAS ORD Oncology 2 7 550.000 424.140 Istituto Superiore di Sanita' ORD Infectious Diseases 7 550.000 and Microbiology MAGGIORE EST Musculoskeletal, 7 550.000 291.140 Oral and Skin Lombardia EST Oncology 1 Basic 7 560.000 296.140 Istituto Superiore di Sanita' ORD Oncology 1 Basic 7 561.000 Toscana ORD Oncology 1 Basic 7 564.000 2313497 Early detection and treatment of recurrent, chemotherapy resistant ovarian cancer stem cells by CPE peptide complexed superparamagnetic iron oxide nanoparticles (CPE SPIONs) ISTITUTO TUMORI MILANO EST Oncology 2 7 570.000 301.240 2309290 Production of novel diagnostic and therapeutic antibodies directed against stem cells in colorectal and lung cancer REGINA ELENA ORD Oncology 2 7 580.000 2312573 2310236 MULTITHERAPEUTIC APPROACH TO THE SPINAL CORD INJURY BYSMART HYDROGEL DELIVERY A novel anti CXCR4 drug RFF 1: a Phase I/II clinical trial. MAGGIORE ORD Brain Disorders and 7 586.000 424.140 PASCALE ORD Oncology 2 7 594.000 Pagina 20 di 332

2320100 Angelman Syndrome: a clinical and functional imaging, molecular and biochemical investigation to uncover new therapeutic strategies MEDEA ORD Brain Disorders and 7 598.500 2304957 FEEDING LOW GRADE INFLAMMATION AND INSULIN RESISTANCE OF THE FOETUS OSPEDALE BAMBINO GESU' ORD Endocrinology, Metabolism, Nutrition and Reproductive 7 599.000 424.140 2312173 2317168 Anterior Cruciate Ligament Reconstruction: biomechanical modeling for treatment selection to prevent Osteoarthritis Prognostic value of a combined panel of soluble and genetic biomarkers in patients with early arthritis RIZZOLI CLI ORD Musculoskeletal, 7 600.000 315.440 Oral and Skin RIZZOLI CLI ORD Musculoskeletal, 7 600.000 322.540 Oral and Skin 2314989 Innovative molecular platform for tick borne diseases: suspension array and pyrosequencing for the rapid, accurate and cost effective multipathogen detection in ticks and biological samples Istituto Zooprofilattico Sperimentale delle Venezie ORD Veterinary 7,25 420.000 274.700 (5) 2303934 Identification of new genes involved in the pathogenesis of rare congenital hemolytic anemias. MAGGIORE CLI ORD Genes, Genomes 7,25 540.000 250.300 and Genetics 2313550 Immunological monitoring of advanced cancer patients undergone active specific immunotherapy with a new anti cancer polypeptide vaccine directed against the thymidylate synthase enzyme. Toscana CLI ORD Oncology 2 7,5 154.000 150.000 2309562 INHIBITION OF BACTERIAL FILMS: NEW MOLECULAR STRATEGIES TARGETING CYCLIC DI GMP METABOLISM Lazio ORD Infectious Diseases 7,5 210.000 and Microbiology 2311417 MicroRNAs regulated by mutated p53 oncoproteins in colon cancer REGINA ELENA ORD Oncology 1 Basic 7,5 230.000 Pagina 21 di 332

2312228 2321713 2318170 2310804 Fall prevention and locomotion recovery in poststroke patients: a multimodal training towards a more autonomous daily life Integrated program of clinical research to reduce the mortality rate of patients on the waiting list for lung transplantation Cognitive, physiological and imaging correlates of visual hallucinations in Lewy body dementia: a multimodality functional study The role of the EGFR in the interaction between mesenchymal stem cells and breast cancer cells: implications for novel therapeutic approaches MAUGERI CLI ORD Musculoskeletal, 7,5 250.000 150.000 Oral and Skin Piemonte CLI ORD Cardiovascular and 7,5 250.000 200.600 Respiratory S.CAMILLO CLI EST Brain Disorders and 7,5 280.000 PASCALE ORD Oncology 1 Basic 7,5 285.000 2318965 Aedes albopictus in northern Italy: molecular markers and mathematical models to predict its potential future spread and the impact of control strategies Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary 7,5 299.000 210.700 (5) 2319302 Structural and functional imaging markers of motor control dysfunction in Tourette syndrome. GALEAZZI ORD Brain Disorders and 7,5 320.000 2312510 IMPACT OF CDKL5 ON NEURONAL FUNCTIONS: GENETIC AND PROTEIN TARGETS, MOLECULAR PATHWAYS AND NEURONAL CIRCUITS SAN RAFFAELE MONTE TABOR ORD Molecular, Cellular, 7,5 338.000 and Developmental 2317593 Role of the meniscus in OA pathology and symptoms RIZZOLI ORD Musculoskeletal, 7,5 350.000 246.300 Oral and Skin 2316264 Deregulation of molecular cross talk between NRF2/KEAP1 and BCL2 pathways in Non Small Cell Lung Cancer (NSCLC) and Small Cell lung Cancer (SCLC): implications for patients treatment. CASA SOLLIEVO SOFFERENZA EST Oncology 2 7,5 350.000 210.700 (4) Pagina 22 di 332

2298992 Modulation of FoxO1 antioxidant function to prevent aging related disorders:diabetes and atherosclerosis Abruzzo EST Biology of 7,5 350.000 Development and Aging 2319582 Involvement of micrornas in triple negative breast cancer: from biology to possible therapeutic applications. ISTITUTO TUMORI MILANO EST Oncology 1 Basic 7,5 363.200 218.800 (4) 2315312 Role of novel modulators of ectopic mineralization during aortic valve disease progression Veneto ORD Vascular and 7,5 375.000 Hematology 2311017 MacroH2A1 in the pathogenesis of metabolic syndrome associated hepatocellular carcinoma CASA SOLLIEVO SOFFERENZA EST Oncology 1 Basic 7,5 379.555 229.000 (4) 2319485 Nanotechnology based approach for induction of immune tolerance Lazio EST Bioengineering 7,5 395.000 and Technologies 2303035 The topological organization of anatomical and functional cortical brain networks in patients with the behavioral variant of frontotemporal dementia and primary progressive aphasia SAN RAFFAELE MONTE TABOR CLI ORD Biobehavioral and 7,5 400.000 322.400 Behavioral Processes 2315883 Schizophrenia pathogenetic mechanisms associated to dysbindin dysfunctions in fly and mouse models MEDEA ORD Brain Disorders and 7,5 400.000 281.800 2313650 White Blood Cells expression profiles as a tool for predicting Metformin Efficacy in Patients with Type 2 Diabetes CASA SOLLIEVO SOFFERENZA ORD Genes, Genomes 7,5 410.000 and Genetics 2313824 Health literacy and patient empowerment through the development of an e health information system Istituto Superiore di Sanita' CLI ORD Healthcare Delivery 7,5 436.667 258.500 and Methodologies Pagina 23 di 332

2318074 2308418 2315284 2318830 IDENTIFICATION OF INNOVATIVE MARKERS AND TECHNOLOGIES FOR SCREENING, DIAGNOSIS AND PROGNOSTIC EVALUATION OF PROSTATE CANCER: CORRELATION WITH ESTABLISHED CLINICAL PARAMETERS GENETIC AND MOLECULAR STUDIES OF TWO AUTISM GENES WITH DIRECT CLINICAL IMPLICATIONS Modulation by IL 1beta of GABAA Receptors function in human and experimental epilepsy: a novel therapeutic approach against adult and childhood intractable epilepsies. Role of the immunological impairment in progression of from MGUS to Multiple Myeloma MULTIMEDICA CLI ORD Oncology 2 7,5 449.700 (2) SANTA LUCIA ORD Brain Disorders and 7,5 450.000 SAN RAFFAELE PISANA ORD Brain Disorders and 7,5 450.000 Sicilia EST Oncology 1 Basic 7,5 460.000 2310716 Role of Th22 lymphocytes in the expression and persistence of psoriatic phenotype: identification of molecular pathways for innovative biologic therapy ISTITUTO DERMOPATICO DELL'IMMACOLATA EST Immunology 7,5 470.000 2316548 Innovative approaches for the treatment of Pompe disease: characterization and identification of potential therapeutic targets in patients with the splicing c. 32 13T>G common mutation and pharmacological chaperoning of alpha glucosidase Friuli Venezia Giulia ORD Genes, Genomes 7,5 474.100 and Genetics 2316099 CROHN'S DISEASE: MECHANISMS OF INTESTINAL FIBROSIS, GENETIC PREDISPOSITION, AND POSSIBLE IMPLICATIONS FOR THERAPEUTIC AND DIAGNOSTIC INTERVENTION CASA SOLLIEVO SOFFERENZA ORD Genes, Genomes 7,5 475.000 and Genetics Pagina 24 di 332

2311864 2316319 2317173 2313390 2318092 2312006 2301677 2321176 Tailoring the choice of P2Y12 oral receptor blocker by integrating clopidogrel loss of function alleles to phenotype assessment via point of care testing versus standard of care in patients who undergo percutaneous coronary intervention: A randomized mult Evaluation of interaction between NK cells and colorectal carcinoma cells for development of NK cell based immunotherapy in patients with refractory disease Role of MSY3 in skeletal muscle maturation and degeneration: a new potential target for therapies against muscle wasting disorders. Amniotic Fluid Stem Cells (AFSCs): molecular markers of osteogenic differentiation and preclinical studies of orthopedic and odontoiatric diseases. Molecular mechanisms underlying metabotropic glutamate (mglu) receptor dysfunction in Fragile X syndrome Role of the RNA binding protein Sam68 in the regulation of SMN2 splicing: implications for novel therapeutic approaches to Spinal Muscular Atrophy Nanotechnology for the multiplex diagnosis of infectious diseases NOVEL APPROACH FOR BONE REGENERATION AND REPAIR USING SULFUR DONOR BASED THERAPY MAUGERI ORD Cardiovascular and 7,5 477.750 336.700 Respiratory SAN MATTEO CLI ORD Oncology 2 7,5 500.000 402.700 SAN RAFFAELE PISANA ORD Musculoskeletal, 7,5 500.000 Oral and Skin Abruzzo EST Biology of 7,5 509.858 Development and Aging OASI MARIA S.S. EST Molecular, Cellular, 7,5 530.000 and Developmental SANTA LUCIA ORD Genes, Genomes 7,5 543.000 and Genetics Istituto Superiore di Sanita' EST Infectious Diseases 7,5 560.000 and Microbiology RIZZOLI EST Musculoskeletal, 7,5 565.000 Oral and Skin Pagina 25 di 332

2302354 Role of micrornas 143 and 145 in cardiovascular physiology and disease: from bench to bedside MULTIMEDICA ORD Vascular and 7,5 578.489 371.200 Hematology 2309585 Development of optical methods for preclinical imaging using radiotracers SAN RAFFAELE MONTE TABOR ORD Bioengineering 7,5 587.400 371.200 and Technologies 2304750 Role of estrogen receptors in the pathogenesis and response to treatment of chronic lymphocytic leukemia Istituto Superiore di Sanita' CLI ORD Oncology 1 Basic 7,5 590.000 475.700 2314131 Circulating nucleic acids in colorectal cancer patients as markers of tumor stroma interactions: new tools for early diagnosis and risk assessment ISTITUTO TUMORI MILANO ORD Oncology 2 7,5 599.500 2302021 AUTOPHAGY AS A NOVEL POTENTIAL DRUG TARGET IN DUCHENNE MUSCULAR DYSTROPHY:IDENTIFICATION OF THE PATHWAYS AND NEW PHARMACOLOGICAL STRATEGIES MEDEA ORD Musculoskeletal, 7,5 600.000 Oral and Skin 2321592 From carcinogenesis to tumor progenitor cells: mirnaome/methylome reprogramming impact on diagnostic and therapeutic innovative options in colorectal cancer CASA SOLLIEVO SOFFERENZA ORD Oncology 1 Basic 7,5 600.000 2316475 2321799 2315604 Alteration in cortical parvalbuminergic System in murine model of Huntington s Disease: Pharmacological effect of Phosphodiesterase type 4 (PDE4) inhibition. Parenteral Iron Supplementation, Chemoreflex Response, Quality of Life And Exercise Capacity In Patients With Chronic Heart Failure Electronic health databases as a source of reliable information for effective health policy SANTA LUCIA ORD Brain Disorders and 7,75 280.000 196.500 AUXOLOGICO CLI ORD Cardiovascular and 7,8 313.000 230.000 Respiratory Puglia CLI ORD Healthcare Delivery 8 150.000 150.000 and Methodologies Pagina 26 di 332

2303748 2313155 2321706 2308551 2316177 2305089 2320236 2315136 2315007 Planar haptic device and virtual reality tools for hand and finger rehabilitation Effects of resveratrol on inflammation in type 2 diabetic patients. A double blind randomised controlled trial The rehabilitation of attention in patients with mild cognitive impairment and brain subcortical vascular changes using the Attention Process Training II Role of antiviral treatment on the course of severe liver disease due to chronic HCV infection Evaluation of the potential neuroprotective, antiepileptogenic and anticonvulsive properties of Palmitoylethanolamide (PEA) Novel therapeutic strategies for Amyotrophic Lateral Sclerosis: testing the efficacy of cellpermeable peptides in preclinical models IMMUNOLOGICAL IMPACT OF SILIBININ TREATMENT FOR HCV RECURRENCE IN STABLE LIVER TRANSPLANTED PATIENTS MSC based therapy for the bone marrow and solid organs transplantations Striatal cholinergic interneurons as a novel target for the treatement of Parkinson's disease S.CAMILLO CLI COF Musculoskeletal, 8 150.000 150.000 Oral and Skin Piemonte CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 8 160.000 150.000 Toscana CLI ORD Brain Disorders and 8 160.000 150.000 Sicilia CLI ORD Digestive, Kidney 8 165.000 150.000 and Urological Systems Calabria ORD Brain Disorders and 8 200.000 MAUGERI ORD Brain Disorders and 8 200.000 Puglia CLI COF Immunology 8 200.000 150.000 Lombardia CLI ORD Oncology 2 8 200.500 150.000 Umbria ORD Brain Disorders and 8 210.000 150.000 Pagina 27 di 332

2302814 MiRNAs in Forebrain Neurogenesis SAN RAFFAELE MONTE TABOR ORD Biology of 8 220.000 Development and Aging 2309222 2299726 2308613 2308936 2312559 Towards development of a next generation sequencing strategy for molecular genetic testing of inherited diseases with blood cell reduction Characterization of micro vesicles in plasma and urine of Alzheimer s disease patients: possible new biomarkers of neurodegeneration Monitoring and development of innovative therapies through microvesicle analysis in kidney and in liver transplantation MALIGNANT MESOTHELIOMA. ROLE OF INFLAMMATION IN TUMOUR PROGRESSION UNDER HYPOXIC CONDITIONS: IDENTIFICATION OF NEW MARKERS AND THERAPEUTIC TARGETS. A pathology for the MET oncogene: "cancers of unknown primary origin" (CUPs) BURLO GAROFALO CLI ORD Vascular and 8 225.000 157.900 Hematology S.CAMILLO ORD Brain Disorders and 8 260.000 Piemonte ORD Digestive, Kidney 8 300.000 and Urological Systems REGINA ELENA ORD Oncology 1 Basic 8 300.000 Piemonte ORD Oncology 1 Basic 8 300.000 2312243 Role of relaxin in bone metastasis Veneto EST Oncology 1 Basic 8 300.000 2315984 Climate, global drivers and immunodeficiency: effects on the leishmaniosis transmission patterns in Central Italy and appropriate diagnostic flow charts Istituto Zooprofilattico Sperimentale del Lazio e della Toscana ORD Veterinary 8 308.000 216.800 2311388 Histaminergic H4 receptor may have a role in autoimmune and inflammatory neuropathologies: studies on the selective H4R agonists and antagonists in animal models in vivo. Toscana ORD Brain Disorders and 8 320.000 Pagina 28 di 332

2321817 Functional and gene expression profile of VH1 69+ primary cutaneous B cell lymphomas and HCVassociated lymphomas ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Oncology 1 Basic 8 330.000 2317994 Role of microrna regulation by estrogen receptor beta in hormone responsive breast cancer CROB ORD Oncology 1 Basic 8 360.000 2314146 Modeling the neurological features of Tuberous Sclerosis Complex by exploiting neural stem cells: translating the results of basic research into predictive preclinical tools. SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 8 360.000 2313991 2318960 2309234 2310524 2310057 2315933 2314003 Toward the development of an in vitro test for ALS: large scale validation of PBMC protein biomarkers Unravelling the genetic basis of limb defects through a combined genomic and functional approach Characterization and functions of ROR{gamma}t+ IL22 producing innate lymphoid cells in autoimmune and neoplastic human diseases The endocannabinoid system as a therapeutic target to counteract remote degeneration after spinal cord injury. The role of TRAP1 in the resistance to anti EGFR1 agents in human colorectal carcinoma Search for novel genes involved in heterogeneous Cryopyrin associated periodic syndromes (CAPS) like autoinflammatory disorders Undifferentiated thyroid carcinoma: role of the Twist1 transcription factor Lombardia CLI ORD Brain Disorders and 8 375.000 170.100 Emilia Romagna ORD Genes, Genomes 8 380.000 267.600 and Genetics Sicilia EST Immunology 8 390.000 SANTA LUCIA CLI ORD Brain Disorders and 8 396.000 185.300 CROB ORD Oncology 2 8 400.000 281.800 GASLINI ORD Genes, Genomes 8 400.000 281.800 and Genetics SDN ORD Oncology 1 Basic 8 400.000 281.800 Pagina 29 di 332

2313919 Identification of therapeutic targets for SAN RAFFAELE MONTE neurological disorders: analysis of the mechanisms TABOR regulating cortical interneurons development. ORD Molecular, Cellular, 8 420.000 and Developmental 2307568 2319022 Role of autophagy in growth, progression and vascular mimicry of neuroblastoma Immune gene expression and white matter pathology in first manic patients before and after treatment. A multimodal imaging genetic study GASLINI ORD Oncology 1 Basic 8 425.000 Veneto CLI ORD Brain Disorders and 8 433.000 305.200 2314623 Immunomodulation by mesenchymal stem cells as a potential therapeutic strategy for endometriosis SAN RAFFAELE MONTE TABOR ORD Endocrinology, Metabolism, Nutrition and Reproductive 8 450.000 2315304 Advanced MRS, ASL perfusion and structural MRI in pediatric migraine: a longitudinal study and correlations with clinical and neurophysiological findings. OSPEDALE BAMBINO GESU' ORD Brain Disorders and 8 455.000 2311171 2317169 2317596 Attention control in complex environments: mechanisms of spatial orienting in the intact and the damaged human brain NACHNOLOGY FOR THE DELIVERY OF ZOLEDRONIC ACID: A NEW OPPORTUNITY AGAINST CANCER INVESTIGATION OF THE MOLECULAR BASES OF CARDIOMYOPATHY IN IMMUNOGLOBULIN LIGHT CHAIN (PRIMARY) AMYLOIDOSIS SANTA LUCIA CLI ORD Integrative, Functional, and Cognitive 8 456.500 212.700 REGINA ELENA ORD Oncology 2 8 467.500 SAN MATTEO ORD Cardiovascular and 8 476.500 335.600 Respiratory 2317212 Development of novel DNA based analytical methods for bacteria detection to improve food safety Istituto Zooprofilattico Sperimentale del Lazio e della Toscana ORD Veterinary 8 480.000 338.700 Pagina 30 di 332

2311298 Targeting CD99 to treat sarcomas RIZZOLI ORD Oncology 2 8 497.200 2316063 2310231 EFFICACY OF TELEMEDICINE FOR IMPROVING DEPRESSION OUTCOMES IN PRIMARY CARE MOLECULAR EVENTS RESPONSIBLE FOR MIGRATORY PLASTICITY AND INVADOPODIA FORMATION IN BONE METASTASIS FROM BREAST CARCINOMA FATEBENEFRATELLI CLI ORD Healthcare Delivery and Methodologies 8 500.000 352.900 GALEAZZI ORD Oncology 1 Basic 8 500.000 2317059 Identification and validation of mirnas as novel biomarkers and therapeutic targets in diffuse malignant peritoneal mesothelioma ISTITUTO TUMORI MILANO EST Oncology 2 8 500.000 2298318 2321704 Kinetochore spindle binding as a new anticancer drug target. Evaluation of anti NA antibodies as possible correlates of protection from influenza disease: development of serological assays designed to detect a truly functional antibody response to influenza vaccination, with specific regard to the anti NA antibody I.E.O. ORD Oncology 2 8 521.300 Istituto Superiore di Sanita' ORD Immunology 8 523.600 2315822 Deleted in Breast Cancer 1, a new player in the DNA damage response. ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 8 539.000 371.200 2320121 Preclinical evaluation of isoform specific PI3K inhibitors' effects in pulmonary fibrosis models for novel potential therapies of Idiopathic pulmonary fibrosis (IPF) Sicilia ORD Cardiovascular and 8 540.000 Respiratory 2320784 Development and preclinical assessment of an innovative endovascular device to occlude prosthetic paravalvular leakage Veneto EST Bioengineering 8 540.000 326.500 (4) and Technologies Pagina 31 di 332

2312686 Nanostructured Coatings Enhancing Material Performances in Joint Arthroplasty RIZZOLI ORD Bioengineering 8 541.000 371.200 and Technologies 2302816 NOVEL THERAPIES FOR TUBERCULOSIS Istituto Superiore di Sanita' ORD Infectious Diseases 8 550.000 and Microbiology 2321788 2320635 2311055 Hyperpolarized 13C Magnetic Resonance Metabolic Imaging as Sensitive Biomarker in a cardiac translational study of Heart Failure Definition of the epigenetic signature in Multiple Myeloma by high resolution DNA methylation profiling and integrated analysis with genomic imbalance, gene and microrna expression. Molecular mechanisms involved in skeletal muscle repair and muscular dystrophy Toscana CLI ORD Cardiovascular and 8 550.000 387.400 Respiratory CROB ORD Oncology 1 Basic 8 550.000 371.200 SAN RAFFAELE PISANA ORD Musculoskeletal, 8 555.000 371.200 Oral and Skin 2311626 Germline predictors of survival and response to therapy in malignant melanoma: from GWAS to high resolution mapping and functional analysis IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 8 572.000 2311360 EPIDEMIOLOGICAL SURVEY ON FRESHWATER FISH BORNE PARASITIC ZOONOSES: STUDY OF TIC AND ATIC FACTORS INFLUENCING THE OCCURRENCE OF ZOONOTIC HELMINTHS IN FRESHWATER FISH POPULATIONS FROM NORTHERN ITALY AND IDENTIFICATION OF MAIN RISK FACTORS CONTRIBUTIN Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary 8 576.125 253.400 (5) 2313291 The novel low density lipoprotein associated protein prenylcysteine lyase: understanding its functional role MONZINO ORD Vascular and 8 577.778 Hematology Pagina 32 di 332

2318370 2309734 2309698 2313418 New nanotechnology and biomedical approaches to improve postoperative pain treatment reducing risks related to opioids Does calorie restriction ameliorate renal function and cardiometabolic health in obese type 2 diabetic patients? Functional characterization and identification of corrective strategies for SCN5A mutations causing Long QT Syndrome 3 and brugada Syndrome. Frontal circuit dysfunction as a marker of dementia in parkinsonism SAN MATTEO CLI EST Surgical, Biomedical Imaging, and Bioengineering 8 580.000 350.900 (4) Istituto Superiore di Sanita' CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 8 583.500 271.700 MAUGERI ORD Cardiovascular and 8 590.000 Respiratory NEUROLESI ORD Brain Disorders and 8 600.000 371.200 2321111 IMPROVING SAFETY OF GENE TRANSFER FOR GENE THERAPY APPLICATIONS SAN RAFFAELE MONTE TABOR ORD Genes, Genomes 8 600.000 and Genetics 2314704 Evaluation of the activity of HIV protease or reverse transcriptase inhibitors against experimental models of uterine cervical tumours Istituto Superiore di Sanita' ORD Oncology 2 8 600.000 2316606 Optimization of alloreactive natural killer (NK) OSPEDALE BAMBINO cell and invariant NKT (inkt) cell mediated antileukemia effect in children with hematological GESU' malignancies given a T cell depleted hematopoietic stem cell transplantation (HSCT) from an HLA disparate rel CLI ORD Oncology 2 8 600.000 296.000 2318396 Identification of novel disease genes for Noonan syndrome and related RASopathies and insights into pathogenetic mechanisms for supporting diagnosis, management and treatment Istituto Superiore di Sanita' ORD Genes, Genomes 8 600.000 and Genetics Pagina 33 di 332

2312766 A multicenter collaborative research network for the identification and study of rare undiagnosed patients: the impact on the rare disease National Health Service network (UnRareNet) OSPEDALE BAMBINO GESU' CLI ORD Healthcare Delivery 8 600.000 423.000 and Methodologies 2311575 2311677 Development of novel cell products for their clinical use in cancer immunotherapy High Throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices Istituto Superiore di Sanita' ORD Oncology 2 8 600.000 Calabria EST Bioengineering 8 600.000 363.100 (4) and Technologies 2302437 RELEVANCE OF TMEM16A PROTEIN (ANOCTAMIN 1) IN THE PATHOPHYSIOLOGY OF CYSTIC FIBROSIS AND GASTROINTESTINAL MOTILITY DISORDERS GASLINI EST Cell Biology 8 600.000 2318880 Prevention and Treatment of Hardware Infection Through Titanium Surface Modifications and Improved Wound Healing Through Nanoparticle Delivery Mechanisms. MAUGERI EST Bioengineering 8 600.000 and Technologies 2316374 Familial breast cancer cases from an isolated population: detection of new risk alleles by exome sequencing and depiction of mutation spectrum in known susceptibility genes. Lombardia CLI ORD Oncology 1 Basic 8,25 302.600 212.700 2321104 2308133 Optoelectronic retinal prosthesis: the astrocyte approach to visual restoration. Exploiting cellular transcription factors of the Interferon Regulatory Factors family in novel therapeutic approaches to HIV 1 infection and reactivation from latency Toscana EST Emerging Technologies and Training in s 8,25 440.000 Istituto Superiore di Sanita' EST AIDS and Related 8,25 546.700 Research Pagina 34 di 332

2314954 2316524 Post partum depression:chronobiology, sleeprelated risk factors and light therapy An opportunistic screening strategy to improve the triage of skin cancer by primary care physicians A randomized study Emilia Romagna CLI EST Risk, Prevention and Health Behavior 8,5 0 ARCISPEDALE CLI ORD Healthcare Delivery 8,5 150.000 150.000 and Methodologies 2321254 Non inferiority trials for cutting drug expenses in neurology: comparing 2 interferon beta 1b regimes in Multiple Sclerosis Lazio CLI ORD Brain Disorders and 8,5 150.000 150.000 2314047 2315581 2317105 2318081 2321801 LKB1/AMPK status and glycolytic phenotype as biomarkers of response of lung cancer to bevacizumab UNRESECTABLE IN TRANSIT METASTATIC MELANOMA: ELECTROCHEMO THERAPY VERSUS ELECTROIMMUNOTHERAPY. LOCAL AND SYSTEMIC EFFECTS. The contribution of ICT to patient safety in surgical process Anti idiotypic Network to Anti transglutaminase Antibodies in the Prevention of Celiac Disease Enteropathy. Development and testing of an entirely automated system, based on administrative data, to stratify prognosis of older patients accessing an Emergency Department I. O. V. CLI ORD Oncology 2 8,5 180.000 150.000 PASCALE CLI COF Oncology 2 8,5 195.000 150.000 Emilia Romagna CLI ORD Healthcare Delivery 8,5 200.000 150.000 and Methodologies BURLO GAROFALO CLI ORD Digestive, Kidney 8,5 200.000 150.000 and Urological Systems Toscana CLI ORD Healthcare Delivery 8,5 200.000 150.000 and Methodologies 2311890 Identification of mirnas involved in the regulation of ALK expression in neuroblastoma IRCCS AOU San Martino IST (Genova) EST Oncology 1 Basic 8,5 200.200 150.000 (4) Pagina 35 di 332

2318138 2318847 2307655 2318970 2317235 2306173 2316490 2316671 Modulation of calcium release activated calcium modulator 1 (ORAI 1) and Stromal interaction molecule 1 (STIM1) activity as a new therapeutical strategy in stroke THE ROLE OF CELL FUSION INDUCED BY TETRASPANIN CD81/CD9 MULTIPROTEIN COMPLEX AS MECHANISM OF CHEMORESISTANCE IN COLON CARCINOMA lipidomic investigations in Multiple Sclerosis: research ofmolecular biomarkers ROLE OF REGULATORY T CELLS IN THE PATHOGENESIS AND THERAPY OF PRIMARY MYELOFIBROSIS Targeting Toll like receptors (TLRs) and their endogenous ligand high mobility group box 1 (HMGB1) as novel therapeutic strategy for Amyotrophic Lateral Sclerosis. NUTRIGENOMICS IN PEDIATRIC INFLAMMATORY BOWEL DISEASES: A NEW BASIS FOR SERUM MARKERS DISCOVERY Membrane remodeling and its role in malaria parasite infection and pathogenesis Functional and structural changes induced by repetitive transcranial magnetic stimulation on corticostriatal pathway in models of Parkinson s disease and dyskinesia SAN RAFFAELE PISANA ORD Brain Disorders and 8,5 217.000 150.500 Toscana ORD Oncology 2 8,5 223.000 Abruzzo ORD Biological Chemistry and Macromolecular Biophysics 8,5 230.000 162.000 SAN MATTEO EST Oncology 2 8,5 240.000 Lombardia ORD Brain Disorders and 8,5 250.000 Veneto ORD Digestive, Kidney 8,5 252.785 and Urological Systems Istituto Superiore di Sanita' EST Infectious Diseases 8,5 260.700 and Microbiology SANTA LUCIA ORD Brain Disorders and 8,5 280.000 196.500 Pagina 36 di 332

2309914 The tumorigenic action of eif6 translational network: 1. evaluation of eif6 inhibition in anticancer therapy and isolation of downstream eif6 targets; 2. generation of SBDS mutated cancer cells and evaluation of their drug sensitivity. SAN RAFFAELE MONTE TABOR ORD Oncology 1 Basic 8,5 290.000 2309329 2313451 2302590 2304935 Searching for a common pathogenetic pathway causing muscle misfunctioning in different laminopathies Hyperthophic cardiomyopathy: new insights from deep sequencing and psycosocial evaluation. Development of new peptide mimetic compounds and small organic molecules targeting the ErbB3/p85 interaction to improve ErbB2 overexpressing metastatic breast cancers therapy Hypoxia in neuroblastoma tumors: from the biology to the identification of novel predictors of outcome RIZZOLI ORD Cell Biology 8,5 300.000 Lombardia CLI COF Cardiovascular and 8,5 300.000 210.700 Respiratory REGINA ELENA EST Oncology 1 Basic 8,5 300.000 GASLINI EST Oncology 1 Basic 8,5 318.600 2317319 Ceruloplasmin oxidation in Parkinson s disease cerebrospinal fluid: role in pathological mechanisms SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 8,5 330.000 2308855 2316179 Paraganglioma syndrome associated with succinate dehydrogenase defects: toward the discovery of biomarkers and novel pharmacological therapies MOLECULAR EPIDEMIOLOGY OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN A THIRD LEVEL PAEDIATRIC UNIVERSITY HOSPITAL I. O. V. ORD Oncology 1 Basic 8,5 343.200 Toscana CLI ORD Infectious Diseases 8,5 345.000 243.200 and Microbiology Pagina 37 di 332

2308779 2315118 2315762 2312443 2313255 2298689 2309640 2318945 Molecular imaging and genome wide analysis: an integrated approach to identify early diagnostic biomarkers. Investigation on the prognostic value of biochemical markers in the cerebrospinal fluid for the functional outcome of spinal cord injured patients Progressive Neurodegeneration in Primary Immunodeficiencies (PIDs): characterization, genetic predisposition, pathogenesis and identification of predictive biomarkers for diagnosis and follow up ISCHEMIC REMOTE POST CONDITIONING AS A NEW THERAPEUTIC STRATEGY TO TREAT CEREBRAL ISCHEMIA Integration of advanced molecular analyses and magnetic resonance imaging for the identification of biomarkers of disease progression in multiple sclerosis. Functional relevance of Natural Killer cells in the pathogenesis of primary sclerosing cholangitis Anosognosia in preclinical and clinical Alzheimer disease as early marker of illness outcome prediction: impact of precocious clinical diagnosis and rehabilitative intervention Disentangling endogenous resident adult cardiac stem cell biology and aging for clinical protocols of myocardial regeneration without cell transplantation REGINA ELENA ORD Oncology 1 Basic 8,5 350.000 Emilia Romagna CLI ORD Brain Disorders and 8,5 400.000 281.800 FATEBENEFRATELLI EST Immunology 8,5 405.020 244.200 (4) SDN ORD Molecular, Cellular, 8,5 419.600 and Developmental Istituto Superiore di Sanita' ORD Brain Disorders and 8,5 422.400 297.000 HUMANITAS ORD Immunology 8,5 444.000 SANTA LUCIA CLI ORD Brain Disorders and 8,5 450.000 200.600 Calabria ORD Cardiovascular and 8,5 450.000 317.400 Respiratory Pagina 38 di 332

2320908 Radiation biodosimetry in emergency: validation of automated scoring and accuracy of dose prediction. IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 8,5 470.000 2313645 2309463 2311253 Paracrine role of Mesenchymal Stem Cells (MSCs) for cell therapy in ALS ROLE OF RIBOFLAVIN TRANSPORTERS IN MOTOR NEURON DISEASES: Genetic analysis of the Brown Vialetto Van Laere and Fazio Londe syndromes and development of potential treatment strategies for motor neuron diseases. Structural imaging in systemic amyloidosis: an inescapable step toward the optimization and validation of more effective therapeutic approaches Piemonte ORD Molecular, Cellular, 8,5 480.000 and Developmental MAGGIORE ORD Molecular, Cellular, 8,5 494.900 348.900 and Developmental SAN MATTEO ORD Biological Chemistry and Macromolecular Biophysics 8,5 500.000 2321220 Generation of artificial lymphoid organs with mutipotent stromal progenitors derived from induced pluripotent stem cells. SAN RAFFAELE MONTE TABOR ORD Biology of 8,5 500.000 Development and Aging 2317812 2305717 MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF MECHANISMS INVOLVED IN IRON HOMESTASIS AND HEME SYNTHESIS IN BETA THALASSEMIC ERYTHROPOIESIS Perinatal life threatening arrhythmias and Sudden Infant death MAGGIORE ORD Genes, Genomes and Genetics 8,5 500.000 SAN MATTEO ORD Genes, Genomes 8,5 520.000 366.100 and Genetics 2319335 Empowering the brain. Induction of Hebbian like plasticity in cortico cortical neural networks with transcranial magnetic stimulation (TMS): investigations of functional connectivity in healthy subjects and clinical trials in stroke patients Lazio EST Brain Disorders and 8,5 520.000 314.300 (4) Pagina 39 di 332

2312316 Perioperative Optimization of Care in Obesity: Acronym: POCO Toscana CLI ORD Surgical, Biomedical Imaging, and Bioengineering 8,5 525.000 255.400 2312853 Search for disease associated genes and their functional mutations in high risk neuroblastoma by parallel massive coding sequences analysis and identification of druggable targets. IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 8,5 531.500 2307262 Identification of treatment dependent and treatment independent biological predictors of chemorefractoriness and outcome in a phase III trial of high risk diffuse large B cell lymphoma (DLCL04) Provincia autonoma Bolzano CLI ORD Oncology 2 8,5 550.000 387.400 2318922 Care pathway for dementia: effects on professional practice, patient outcomes, and costs for the NHS. CARLO BESTA CLI ORD Brain Disorders and 8,5 550.000 302.100 2312023 MEF promotes stemness in the pathogenesis of gliomas FATEBENEFRATELLI ORD Oncology 1 Basic 8,5 550.000 371.200 2310981 Congenital Myopathies: genetic screening starting from a new diagnostic algorithm OSPEDALE BAMBINO GESU' CLI EST Musculoskeletal, 8,5 550.000 332.600 (4) Oral and Skin 2314538 Development of beta cell specific aptamers as novel diagnostic and therapeutic tools for diabetes mellitus. SAN RAFFAELE MONTE TABOR ORD Surgical, Biomedical Imaging, and Bioengineering 8,5 566.000 2316776 A machine learning approach to pharmacogenomics. Application to therapy of autoimmune diseases, Myastenia Gravis and Multiple Sclerosis. CARLO BESTA CLI ORD Genes, Genomes 8,5 571.300 282.800 and Genetics Pagina 40 di 332

2312524 EVALUATION OF HUMAN ADIPOSE TISSUE DERIVED STROMAL CELLS FOR THE TREATMENT OF DIABETIC CARDIOVASCULAR COMPLICATIONS SAN RAFFAELE PISANA EST Endocrinology, Metabolism, Nutrition and Reproductive 8,5 580.000 2308100 Targeting strategies in Numb defective cancers I.E.O. ORD Oncology 1 Basic 8,5 585.000 371.200 2312769 2316138 2309867 2321552 2319289 DESIGNING MOLECULAR CHAPERONS FOR PROTEINS: A NEW STRATEGY FOR DRUG DISCOVERY IN NEURODEGENERATIVE DISEASES INNOVATIVE METHOD FOR THE TREATMENT OF TOTAL LIMBAL STEM CELLS DEFICIENCY (LSCD) THROUGH A TISSUE ENGINEERED HEMICORNEA Targeting myeloid cells with novel nanotechnology based platforms to control metastatic disease The use of an innovative microarray platform into the clinical setting DNA damage response and metabolic alterations of obesity Istituto Superiore di Sanita' ORD Molecular, Cellular, 8,5 590.500 371.200 and Developmental Veneto CLI ORD Bioengineering 8,5 596.000 275.700 and Technologies Veneto EST Oncology 1 Basic 8,5 596.000 Sicilia ORD Genes, Genomes 8,5 597.300 and Genetics Istituto Superiore di Sanita' ORD Endocrinology, Metabolism, Nutrition and Reproductive 8,5 600.000 2317550 Investigating KAP1 mediated epigenetic control of differentiation and function of adaptive immune system SAN RAFFAELE MONTE TABOR ORD Immunology 8,5 600.000 371.200 Pagina 41 di 332

2319311 CLINICAL RELEVANCE OF IMMUNE RESPONSES TO PROPHYLACTIC HPV VACCINE IN ITALY:A NATIONAL IMMUNOMONITORING NETWORK Istituto Superiore di Sanita' ORD Immunology 8,5 600.000 2306857 2308322 2309591 Investigation of the role of extracellular ATP and the P2X7 receptor in the modulation of imunosuppression within tumour microenvironment. Development of new antiinflammatory/immunosuppressive therapy to improve the outcome of brain injury. Impact of asbestos mediated inflammation in mesothelioma genesis and progression. Implication for early diagnosis, prognosis and therapy Emilia Romagna ORD Immunology 8,5 600.000 NEUROLESI ORD Brain Disorders and 8,5 600.000 HUMANITAS ORD Oncology 1 Basic 8,5 600.000 2303697 Redox dysfunctions in autoinflammatory syndromes. Role in disease course, novel therapeutic approaches IRCCS AOU San Martino IST (Genova) ORD Immunology 8,5 600.000 2320979 Genomics, epigenomics and transcriptomic investigation of defective peripheral tolerance in IPEX like patients SAN RAFFAELE MONTE TABOR ORD Genes, Genomes 8,5 600.000 and Genetics 2316745 2303444 SPES Service for detection of Pre psychoses: from gene environment interactions to phenomenology TARTEGED TREATMENT OF HAIRY CELL LEUKEMIA MEDEA ORD Brain Disorders and 8,5 600.000 371.200 Umbria CLI ORD Oncology 2 8,5 600.000 210.700 Pagina 42 di 332

2315839 2320644 Direct Acting Antivirals (DAAs) for HCV infection: a nationwide research project to evaluate virological and clinical outcomes, to design appropriate treatment algorithms, and to assess cost effectiveness of the new combination therapies THE RESPONSIVENESS TO CLOPIDOGREL AND STENT THROMBOSIS 3 (RECLOSE 3) TAILORED THERAPY Istituto Superiore di Sanita' CLI ORD Infectious Diseases and Microbiology 8,5 600.000 423.000 Toscana CLI ORD Cardiovascular and 8,5 600.000 423.000 Respiratory 2309553 Recovery to heart donation of donor hearts with neurogenic stunning identified as eligible by stress echo viability assessment. Emilia Romagna ORD Surgical, Biomedical Imaging, and Bioengineering 8,5 600.000 2319081 Hypertension in high school students: Genetic and Environmental Factors Toscana CLI EST Population 8,5 600.000 and Epidemiology 2309251 Role of Ezh2 in DNA damage response REGINA ELENA EST Oncology 1 Basic 8,5 600.000 2320561 2319551 Regulation of cancer stem cell symmetric divisions by myc A multicenter epidemiological and clinical study on Deep Brain Stimulation (DBS) for Parkinson s disease: adherence to current recommendations, safety and outcome. I.E.O. EST Oncology 1 Basic 8,5 600.000 MAGGIORE CLI ORD Brain Disorders and 8,75 257.100 150.000 2316566 Search for new genes and new therapies for Neonatal Diabetes Mellitus (NDM) and Hyperinsulinism and Hypoglycemia (HH). OSPEDALE BAMBINO GESU' CLI EST Endocrinology, Metabolism, Nutrition and Reproductive 8,75 300.000 Pagina 43 di 332

2312035 2317811 2307889 Purinergic modulation of SDF 1/CXCR4 directed endothelial and cardiac progenitors cell functions: theraupetic potential in cardiovascular regeneration. Isolated Hemihyperplasia (IH), a pediatric cancer risk disease: search for novel genes and mechanisms The role of macrophages in Primary Biliary Cirrhosis: novel targets for immune intervention SAN RAFFAELE PISANA ORD Cardiovascular and 8,75 450.000 Respiratory AUXOLOGICO ORD Genes, Genomes 8,75 462.000 and Genetics HUMANITAS EST Immunology 8,75 539.000 2312549 Heterotypic interactions in thromboinflammatory processes associated with the TABOR SAN RAFFAELE MONTE thrombotic vascular occlusion in sepsis: the role of vitamin K dependent protein C ORD Vascular and 8,75 600.000 Hematology 2317873 2318865 2322017 2318554 Supporting an early autism spectrum disorders diagnosis through the support vector machine approach The Lausanne Trilogue Play used as a psychodiagnostic and therapeutic tool in a Neuropsychiatric Unit: an innovative clinical experience working with psychitric children and adolescent The implementation of an enhanced recovery program ( fast track) after colorectal resection for colonic cancer Assessment of Stable and Unstable atherosclerotic plaque in coronary disease using Positron Emission Tomography Computed Tomography (PET TC) and Optical Coherence Tomography (OCT).[SUSPECT trial] STELLA MARIS CLI ORD Brain Disorders and 9 150.000 150.000 Veneto CLI ORD Risk, Prevention 9 150.000 150.000 and Health Behavior Emilia Romagna CLI ORD Surgical, Biomedical Imaging, and Bioengineering 9 150.000 150.000 Lazio CLI ORD Cardiovascular and 9 150.000 150.000 Respiratory Pagina 44 di 332

2322039 2319386 2308995 2304510 2307228 2317133 Porous titanium combined with an osteoinductive hydrogel and cells: an innovative strategy to improve prosthetic implants osteointegration Exercise and inflammation in obesity. Evaluation of relationships and possible interventions. (ObInEx Project) Manufacturing information of orthopedic articular prosthesis. Analysis of specific safety issues for radiotherapy, magnetic resonance, orthopedic surgery and identification of a traceability model. CERVICAL PLETHYSMOGRAPHY: A NEW TOOL FOR NON INVASIVE ASSESSMENT OF CEREBRAL VENOUS RETURN, AND A POSSIBLE SCREENING DEVICE FOR CHRONIC CEREBROSPINAL VENOUS INSUFFICIENCY Assessing the effect of an intensive rehabilitation treatment(irt) on neurotrophic factors production in patients with Parkinson s disease Systematic review on the interventions to reduce waiting lists for elective procedures GALEAZZI COF Musculoskeletal, 9 150.000 150.000 Oral and Skin DON GNOCCHI ORD Endocrinology, Metabolism, Nutrition and Reproductive 9 162.000 Emilia Romagna CLI ORD Healthcare Delivery 9 185.000 150.000 and Methodologies Emilia Romagna CLI COF Vascular and 9 190.000 150.000 Hematology MAUGERI ORD Brain Disorders and 9 200.000 Emilia Romagna CLI ORD Healthcare Delivery 9 200.000 150.000 and Methodologies 2318192 Oral steroids for reducing renal scarring in infants with febrile urinary tract infections at high risk for renal scar development: a randomized controlled trial Veneto CLI ORD Infectious Diseases 9 200.000 150.000 and Microbiology 2319605 Polypharmacy Reduction of Inappropriate Medication and Adverse Drug Events in Older Patients: a Randomized Controlled Trial PRIMA Provincia autonoma Bolzano CLI ORD Healthcare Delivery 9 205.000 150.000 and Methodologies Pagina 45 di 332

2320995 From NAFLD to HCC: mouse model and definition of predisposing and prognostic factors for human liver disease management. Marche ORD Digestive, Kidney 9 210.000 and Urological Systems 2319668 Early Detection in Autism Spectrum Conditions STELLA MARIS CLI ORD Brain Disorders and 9 230.000 162.000 2307929 2318552 2307215 2317957 2317972 2309748 BORON NEUTRON CAPTURE THERAPY (BNCT) IN CUTANEOUSRECURRENCES OF BREAST CANCER: THE DIAGNOSTIC AND THERAPEUTICUTILITY OF 18F FBPA PET/CT PREDICTION AND PREVENTION OF FALLS IN SUBJECTS SUFFERING FROM NEUROLOGICAL DISEASES Radiolabelled nanoparticles as radiopharmaceuticals for preclinical drug development with molecular imaging in angiogenesis Biochemical markers of brain damage following epileptic seizures in children and correlation with cognitive outcome and quantitative imaging data DNA vaccines coding for chimeric human/rat HER 2 as innovative immunotherapeutic tools for the treatment of HER2+ cancer patients MAPPING THE CORTICOSPINAL TRACT: INVESTIGATION OF FUNCTIONAL PROPERTIES OF THE DIFFERENT CORTICAL AREAS ORIGINATING CST AND THEIR CLINICAL IMPACT ON TUMOR RESECTION AND PATIENT FUNCTIONAL OUTCOME I. O. V. CLI ORD Oncology 2 9 232.000 150.000 Lombardia CLI ORD Risk, Prevention 9 255.300 150.000 and Health Behavior Toscana ORD Bioengineering 9 265.000 and Technologies Toscana CLI EST Brain Disorders and 9 265.000 Piemonte ORD Oncology 2 9 270.000 HUMANITAS CLI ORD Integrative, Functional, and Cognitive 9 272.800 191.400 Pagina 46 di 332

2310116 A randomized controlled trial of diet and physical activity in BRCA mutation carriers ISTITUTO TUMORI MILANO CLI ORD Risk, Prevention 9 286.000 201.600 and Health Behavior 2302555 2319611 IDENTIFICATION AND VALIDATION OF NEW THERAPEUTIC TARGETS FOR MULTIPLE MYELOMA PATIENTS Brain Computer Interface driven rehabilitation after stroke: an add on intervention for hand motor recovery Emilia Romagna EST Oncology 1 Basic 9 287.777 SANTA LUCIA CLI ORD Brain Disorders and 9 290.000 150.000 2320098 IMPACT OF VITAMIN D SUPPLEMENTATION ON SKELETAL AND NON SKELETAL MANIFESTATIONS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM SUBMITTED TO PARATHYROIDECTOMY OR FOLLOWED WITHOUT SURGERY CASA SOLLIEVO SOFFERENZA CLI ORD Healthcare Delivery 9 290.000 203.600 and Methodologies 2315893 Antiepileptic Drugs and pregnancy. Population based pharmaco epidemiological study on prescription patterns, pregnancy outcome and foetal health Istituto Scienze Neurologiche CLI ORD Population 9 300.000 210.700 and Epidemiology 2320691 MICRORNA IN THYROID CARCINOMA: PATHWAYS INVOLVED AND POSSIBLE PROGNOSTIC AND THERAPEUTIC IMPACT ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 9 300.000 2318903 2317863 Pharmacological treatments plus mesenchymal stem cell transplantation as novel therapeutic approach in cerebral ischemia Epigenetic remodeling of ncx1 gene by drugs inhibiting histone deacetylases (HDACs) class I: a new strategy to reduce the neuronal damage in brain ischemia Toscana ORD Brain Disorders and 9 300.000 SDN ORD Brain Disorders and 9 337.000 Pagina 47 di 332

2312855 2303797 2304892 Deciphering the genetic complexity of myeloproliferative neoplasms and the molecular pathways involved in disease progression Effect of proteasome and VEGF receptor inhibitors on NKG2D ligand expression on hepatocellular carcinoma cells: implications for immunotherapy of liver cancer. Human Well Being: a Twin Study on the Relation between Optimal Psychological and Biological Functioning SAN MATTEO ORD Vascular and 9 342.000 Hematology SAN MATTEO ORD Oncology 2 9 350.000 Istituto Superiore di Sanita' ORD Biobehavioral and 9 350.000 Behavioral Processes 2321501 Biological bone reconstruction in children skeleton after sarcoma resection. Validation of the technique through CT scan analysis and histological evaluation of the retrieved cases RIZZOLI CLI ORD Surgical, Biomedical Imaging, and Bioengineering 9 350.000 196.500 2319005 Dual ErbB 3 and PI3K/AKT pathway inhibition as a novel approach to targeting cancer Abruzzo EST Oncology 2 9 350.000 2314764 2317828 CHANGES IN STRUTTURE AND RECRUITMENT OF MUSCLE SYNERGIES AFTER CORTICAL AND CEREBELLAR LESIONS NEURONAL POTASSIUM CHANNEL KV3.4 AS A NON TRADITIONAL MOLECULAR TARGET FOR THE DEVELOPMENT OF DRUGS PREVENTING NEURONAL CELL DEATH IN ALZHEIMER DISEASE SANTA LUCIA ORD Integrative, Functional, and Cognitive 9 354.889 SAN RAFFAELE PISANA ORD Molecular, Cellular, 9 360.000 and Developmental 2311487 Muscle fibrosis in DMD: Molecular characterization with a new human in vitro model and therapeutic approach CARLO BESTA ORD Musculoskeletal, 9 376.100 Oral and Skin Pagina 48 di 332

2319571 2320653 2321796 2314575 2321812 Noise and air pollution from road traffic and incidence of coronary and cerebrovascular events in three Italian cohort studies Role of trace element in the pathogenesis of Multiple sclerosis Acute coronary syndrome and long term outcome: the role of nitric oxide synthesis in red blood cells Diagnosis of attention deficit/hyperactivity disorder (ADHD) in adults by quantitative EEG and transcranial magnetic stimulation markers. Polymeric films and magnetic forces for gallbladder retraction during a fully translumenal cholecystectomy Lazio CLI ORD Population 9 380.000 267.600 and Epidemiology Istituto Superiore di Sanita' ORD Population 9 388.223 and Epidemiology MONZINO ORD Cardiovascular and 9 389.500 Respiratory OASI MARIA S.S. ORD Biobehavioral and 9 400.000 Behavioral Processes Piemonte ORD Surgical, Biomedical Imaging, and Bioengineering 9 400.000 2298966 Pre clinical assessment of innovative treatments against malignancies based on micrornas ISTITUTO DERMOPATICO DELL'IMMACOLATA EST Oncology 2 9 400.500 2317750 2312568 Targeting neuroprotective endogenous neural stem cells in stroke A WEB based, paperless and open source implementation of IHE radiological and nuclear medicine workflow SANTA LUCIA CLI EST Brain Disorders and 9 407.000 Veneto ORD Healthcare Delivery 9 410.000 and Methodologies 2318002 Novel multiplexing and signal amplification strategies for the development of advanced diagnostic platforms for animal health and food safety control Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary 9 420.000 237.100 (5) Pagina 49 di 332

2318116 Next generation seqencing technologies applied to mantle cell lymphoma: a tool to understand its pathogenesis and to identify novel biomarkers and therapeutic approaches Veneto ORD Oncology 1 Basic 9 428.000 2316707 2305546 2319407 2320783 2312561 2314264 2319429 2305963 Revealing brain mechanisms of Chronic Subjective Dizziness Mitochondrial Carrier Diseases: prevalence, study of pathogenetic mechanisms, and possible therapies A Janus role of autophagy in Cystic Fibrosis: a new therapeutic approach? Obesity associated Flt3 mutations in Acute Promyelocytic Leukemia: investigating a novel paradigm for the cancer promoting effect of obesity IMMUNOSUPPRESSIVE AND REGENERATIVE CAPACITY OF AUTOLOGOUS ADIPOSE DERIVED MESENCHIMAL STEM CELLS FOR THE TREATMENT OF PATIENTS WITH CROHN DISEASE METHODS FOR NON INVASIVE QUANTITATIVE ASSESSMENT OF FATTY LIVER MicroRNAs as molecular biomarkers for early detection of sporadic Fronto temporal Dementias Role of IBtk, a B cell signalling regulator, in cancer development. SANTA LUCIA ORD Integrative, Functional, and Cognitive 9 440.000 STELLA MARIS ORD Brain Disorders and 9 441.000 Istituto Superiore di Sanita' ORD Cardiovascular and 9 450.000 Respiratory I.E.O. ORD Oncology 1 Basic 9 450.000 Emilia Romagna CLI ORD Digestive, Kidney 9 450.000 317.400 and Urological Systems SDN CLI ORD Digestive, Kidney 9 450.000 176.200 and Urological Systems Umbria ORD Brain Disorders and 9 460.000 Calabria ORD Cell Biology 9 460.000 Pagina 50 di 332

2313474 GENETIC SUSCEPTIBILITY AND PHARMACOGENETICS OF MULTIPLE MYELOMA AND MGUS Toscana ORD Oncology 1 Basic 9 470.000 2299942 Epigenetic signatures in human glioblastoma cells: implications for tumor biology and treatment IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 9 478.500 2313100 2313775 2312253 Deep molecular mechanisms of amyloid beta peptide aggregation promoting Alzheimer s Disease: characterization with Nuclear Magnetic Resonance (NMR) techniques using an in vitro model of anesthetic inducing oligomerization Molecular mechanisms of neutrophil recruitment as novel targets to curb lung damage in cystic fibrosis. Characterization of the genomic architecture of myelodysplastic syndromes and definition of a molecular basis for their classification and prognostication NEUROLESI ORD Brain Disorders and 9 480.000 Abruzzo ORD Cardiovascular and 9 480.000 Respiratory SAN MATTEO ORD Oncology 1 Basic 9 486.000 2315177 New tools to identify effective SMA therapeutics: a protein fragment complementation assay coupled to snrnp biogenesis to measure the SMN complex activity in SMA cells SANTA LUCIA ORD Genes, Genomes 9 490.000 and Genetics 2313561 Defining non invasive outcome measures and elucidating the molecular mechanisms underlying muscle degeneration in Facioscapulohumeral muscular dystrophy DON GNOCCHI ORD Musculoskeletal, 9 493.000 Oral and Skin 2310570 DECISION SUPPORT SYSTEM TO IMPROVE APPROPRIATENESS OF REPEATED EXECUTION OF LABORATORY EXAMINATIONS Emilia Romagna CLI ORD Healthcare Delivery 9 500.000 352.900 and Methodologies Pagina 51 di 332

2319077 2298782 Role of mirnas in inflammatory synaptopathy in a mouse model of MS Role of Chromatin Remodeling in Epigenetic Cell Memory SANTA LUCIA ORD Brain Disorders and 9 500.000 SANTA LUCIA ORD Genes, Genomes 9 500.000 and Genetics 2317549 Aberrant choline metabolism in ovarian cancer as a source of multilevel data in prognosis and/or therapeutic guidance. ISTITUTO TUMORI MILANO ORD Oncology 2 9 505.000 2302218 2313251 2312952 2318732 ADVANCED CLINICAL AND MOLECULAR EFFORTS IN HEREDITARY SPASTIC PARAPLEGIA An in vitro ad in vivo imaging approach to myelin dysfunction and reconstruction after stroke: role of GPR17, a new player in oligodendrocyte specification PKC beta as new target to prevent pharmacologically induced weight gain during antipsychotic treatment. HIGH THROUGHPUT TECHNOLOGIES FOR UNCOVERING NEW DIAGNOSTIC MARKERS FOR EARLY DIAGNOSIS OF CHRONIC ALLOGRAFT INJURY IN RENAL TRANSPLANTATION (CAI) STELLA MARIS ORD Brain Disorders and 9 518.000 MONZINO ORD Brain Disorders and 9 527.500 Emilia Romagna ORD Endocrinology, Metabolism, Nutrition and Reproductive 9 550.000 Puglia ORD Digestive, Kidney 9 550.000 and Urological Systems 2306483 RAPAMYCIN PLUS DPPIV INHIBITOR IN IMPROVING BETA CELL FUNCTION IN LONG STANDING TYPE 1 DIABETES: PROSPECTIVE RANDOMIZED TRIAL SAN RAFFAELE MONTE TABOR EST Endocrinology, Metabolism, Nutrition and Reproductive 9 550.000 Pagina 52 di 332

2317430 2319745 2305958 Advanced diagnosis and therapies for migraine caused by K+ channel dysfunction Presbyphagia: analysis of diagnostic criteria and identification of potential innovative treatments Optimization of plasma progranulin dosage for predicting null progranulin mutations in neurodegenerative diseases: A pilot Multicentre Italian Study for harmonization of procedures to be translated into clinical practice MONDINO ORD Molecular, Cellular, 9 562.000 and Developmental MONDINO CLI ORD Healthcare Delivery 9 563.000 326.500 and Methodologies FATEBENEFRATELLI ORD Brain Disorders and 9 580.000 2315686 Characterizations of the anti Tat adaptative immune responses in individuals naturally controlling HIV 1 replication SAN RAFFAELE MONTE TABOR ORD AIDS and Related 9 580.000 Research 2308980 Dissecting the CLL lipidome in search for novel SAN RAFFAELE MONTE prognostic markers and targets for tailored therapy TABOR ORD Oncology 2 9 580.000 2310977 2321646 2321747 Normalization of defective calcium handling in cardiac pathologies: innovative strategies and potential therapeutical applications The impact of local sleep on awake human behavior Early diagnosis, tumor response to neoadjuvant treatments and diagnosis of tumor recurrence using new and non invasive biomarkers in colon and rectal cancer HUMANITAS ORD Cardiovascular and 9 580.000 Respiratory Toscana EST Integrative, Functional, and Cognitive 9 580.000 I. O. V. ORD Oncology 2 9 584.100 2320339 Genetic characterization of supraventricular arrhythmias by whole exome sequencing SAN RAFFAELE MONTE TABOR ORD Cardiovascular and 9 590.000 Respiratory Pagina 53 di 332

2308659 Pathogenesis of congenital human cytomegalovirus infection SAN MATTEO ORD Infectious Diseases 9 590.000 and Microbiology 2307872 THE ROLE OF CALCIUM HOMEOSTASIS IN DEVELOPMENTAL ATAXIAS: genetic dissection and functional characterization of a neuronal specific plasma membrane Ca2+ ATPase. OSPEDALE BAMBINO GESU' ORD Molecular, Cellular, 9 597.000 and Developmental 2308622 Cdk5 in tumor progression. HUMANITAS ORD Oncology 1 Basic 9 600.000 2319770 Surviving ER stress: lessons from a CMT1B neuropathy model SAN RAFFAELE MONTE TABOR ORD Molecular, Cellular, 9 600.000 and Developmental 2313671 A combination of surveys, spatial analyses and molecular epidemiology to get an insight of preharvest risks from Shiga toxin producing Escherichia coli. Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary 9 600.000 327.500 (5) 2321182 Role of the microbiota and peripheral biomarkers in weight restoration and weight maintenance in patients with Anorexia Nervosa. FATEBENEFRATELLI ORD Brain Disorders and 9 600.000 2312085 MODULATING NEUREGULIN 1 SIGNALS TO TREAT HEREDITARY DEMYELINATING NEUROPATHIES SAN RAFFAELE MONTE TABOR ORD Molecular, Cellular, 9 600.000 and Developmental 2306876 Investigation of brain functional connectivity by graph based network analysis: application to normal ageing and prodromal Alzheimer s disease. CARLO BESTA ORD Brain Disorders and 9 600.000 2316352 Identification of new biomarkers for metabolic syndrome associated with antipsychotic treatment FATEBENEFRATELLI ORD Biobehavioral and 9 600.000 Behavioral Processes 2317531 Recurrent herpes virus infections as risk factor for Alzheimer`s disease SAN RAFFAELE PISANA ORD Infectious Diseases 9 600.000 and Microbiology Pagina 54 di 332

2309418 Role of Che 1 in DNA damage response REGINA ELENA ORD Oncology 1 Basic 9 600.000 2314491 2318137 2320696 2319462 2311550 2316359 2312497 2302355 2310976 Cortico cortical functional connectivity and recovery of post stroke spatial attention and awareness disorders Targeting altered proton dynamics of sarcomas as an effective therapeutic tool Novel multi scale approach to 3d cancer models for the discovery of new therapeutic strategies for bone metastases Nanometer size Gold Clusters Bioconjugates for Efficient Drug Delivery Predictive factors of response to therapies in colorectal and breast cancers. Longitudinal clinical neuropsychological study of subjective memory complaints Adaptation to predictable postural perturbations: physiological basis for an innovative approach to dynamic balance training in Parkinson s disease Innovation, education and treatment of drug abuse with dual diagnosis (INNUENDO) Dissecting host parasite interactions by RNA interference knock down of erythrocyte membrane microdomain proteins SANTA LUCIA ORD Integrative, Functional, and Cognitive 9 600.000 RIZZOLI ORD Oncology 2 9 600.000 GALEAZZI EST Oncology 1 Basic 9 600.000 C.R.O. AVIANO EST Oncology 2 9 600.000 MAUGERI ORD Oncology 1 Basic 9,17 390.000 Toscana CLI ORD Brain Disorders and 9,25 150.000 150.000 MAUGERI CLI ORD Brain Disorders and 9,25 240.000 169.100 Abruzzo CLI EST Risk, Prevention 9,25 300.000 and Health Behavior Istituto Superiore di Sanita' ORD Infectious Diseases 9,25 345.000 and Microbiology Pagina 55 di 332

2320147 Extracellular iron as a key signal in muscle necrosis and regeneration SAN RAFFAELE MONTE TABOR EST Immunology 9,25 350.000 2309474 EXACT EXPLORING ACTIONS: A FUNCTIONAL APPROACH TO DECODE REPRESENTATION OF MOTOR ACTS IN THE HUMAN BRAIN Toscana ORD Biobehavioral and 9,25 480.000 Behavioral Processes 2320094 2316726 2306755 Gene identification in rare genetic disorders affecting lysosomal degradation pathways in skeletal muscle. Role of HIV 1 infection on colorectal carcinoma onset and progression: development of novel therapeutic strategies Gene environment interaction in top down regulation of compulsive eating: a translational study of food addiction CARLO BESTA EST Musculoskeletal, 9,25 480.800 Oral and Skin Istituto Superiore di Sanita' EST AIDS and Related 9,25 533.500 Research SANTA LUCIA ORD Brain Disorders and 9,25 600.000 2313864 Role of hypoxia induced mir 210 in tissue response to peripheral ischemia ISTITUTO DERMOPATICO DELL'IMMACOLATA EST Vascular and 9,25 600.000 Hematology 2312339 2304417 2312659 Role of DNA methylation in diagnosis and prognosis of prostate cancer. Improved pre surgical evaluation of the human epileptogenic zone with a novel intracranial recording/analysis platform Effects of proton pump inhibitors on mortality and rehospitalization in older subjects : focus on the insulin like growth factor system and implications for health care system. Piemonte ORD Oncology 1 Basic 9,5 150.150 CARLO BESTA COF Brain Disorders and 9,5 151.000 150.000 Emilia Romagna CLI ORD Population 9,5 156.500 150.000 and Epidemiology Pagina 56 di 332

2312196 Effects of testosterone supplementation on erythropoiesis: potential therapeutic implications in the anemia of older patients Emilia Romagna CLI EST Endocrinology, Metabolism, Nutrition and Reproductive 9,5 157.500 2320549 Prostacyclin in microsurgical flaps. Sicilia ORD Surgical, Biomedical Imaging, and Bioengineering 9,5 160.000 2314841 2320550 2318620 2316964 2303761 2313869 2320288 Role of 18F FLT PET/CT in patients with suspect lymphoma relapse Evaluation of extrapyramidal involvement in amyotrophic lateral sclerosis (ALS): a prospective cohort survey Optimizing and integrating the delivery of primary care services for risky drinkers in Region Friuli Venezia Giulia Functional significance of manipulating endogenous neurogenesis for nigrostriatal dopaminergic neuroprotection/neurorepair in murine models of Parkinson s disease: focus on neuroinflammation HIV 1 Tat interaction with host microrna regulatory network: implications for immune dysregulation Sorafenib as Adjuvant Treatment in the Prevention Of Recurrence of Hepatocellular Carcinoma Control of telomeric DNA topology in normal and cancer cells Emilia Romagna CLI ORD Oncology 2 9,5 160.000 150.000 Piemonte CLI ORD Brain Disorders and 9,5 175.000 150.000 Friuli Venezia Giulia CLI ORD Healthcare Delivery 9,5 175.000 150.000 and Methodologies OASI MARIA S.S. ORD Brain Disorders and 9,5 200.000 Calabria ORD AIDS and Related 9,5 200.000 Research Emilia Romagna ORD Oncology 2 9,5 200.000 REGINA ELENA ORD Cell Biology 9,5 200.000 Pagina 57 di 332

2311772 The role of T cells in postmenopausal bone loss: Piemonte EST Immunology 9,5 205.000 focus on autoreactive T cells in peripheral blood of patients affected by severe form of osteoporosis. 2319503 THE USE OF MRI DERIVED MARKERS TO EARLY PREDICT CONSCIOUSNESS RECOVERY INCOMATOSE PATIENTS Lombardia CLI ORD Brain Disorders and 9,5 224.000 156.900 2319223 Adverse Health Effects of Airborne Particle Pollution: a multidisciplinary study IRCCS AOU San Martino IST (Genova) ORD Population 9,5 234.000 and Epidemiology 2321615 Smoke and uremic toxins activate the aryl hydrocarbon receptor pathway in monocytes: relevance for the development of abdominal aortic aneurysm. IRCCS AOU San Martino IST (Genova) ORD Vascular and 9,5 244.500 Hematology 2322045 Application of multilocus sequence typing (MLST) for surveillanceof Candida infections in hospital care units and use of PCR based methodologies to determine the frequency and distribution of emerging new cryptic Candida species. NEUROLESI ORD Infectious Diseases 9,5 250.000 and Microbiology 2311107 ROLE OF THE DNAM 1/PVR PATHWAY IN THE PATHOGENESIS OF HIV 1 INFECTION OSPEDALE BAMBINO GESU' EST AIDS and Related 9,5 252.500 Research 2321019 2308905 2313113 Disease related biomarkers investigation in Multiple sclerosis by analysis of microvesicles isolated by CSF. Reactive oxygen species (ROS) and phosphoinositide 3 kinase (PI3K) signalling in breast cancer Whole genome scanning in AML to develop a better prognostic stratification and personalized risk based therapies Sicilia ORD Molecular, Cellular, 9,5 270.000 and Developmental Abruzzo EST Oncology 1 Basic 9,5 290.451 SAN MATTEO ORD Oncology 2 9,5 300.000 Pagina 58 di 332

2317060 Role of sphingolipids in white matter dysfunctions in neurodegenerative disorders NEUROMED ORD Brain Disorders and 9,5 300.000 2321968 CENTRAL EFFECTS OF BOTULINUM NEUROTOXINS: THERAPEUTIC IMPLICATIONS Toscana ORD Brain Disorders and 9,5 300.000 2315207 Necdin role in myogenic stem cells self renewal and maintenance for the repair of the dystrophic muscle SAN RAFFAELE MONTE TABOR ORD Musculoskeletal, 9,5 300.000 Oral and Skin 2320337 2311282 Study of the involvement of the microbiota in intestinal tumorigenesis: emphasis on APC gene regulation. EFFECTS OF LESIONS OF PARIETAL AND FRONTAL CORTEX ON BOTTOM UP FEATURE DETECTION IN THE HUMAN VISUAL CORTEX: CLINICAL/REHABILITATIVE IMPLICATIONS FOR DISORDERS OF SPATIAL ATTENTION IN STROKE PATIENTS I.E.O. ORD Oncology 1 Basic 9,5 306.555 SANTA LUCIA CLI ORD Brain Disorders and 9,5 311.600 189.400 2311519 DEFINING INNOVATIVE TREATMENT STRATEGIES FOR OSTEOSARCOMA BASED ON THE INHIBITION OF ABC TRANSPORTERS AND PROTEIN KINASES RIZZOLI ORD Oncology 2 9,5 330.000 2319057 Robotic Therapy for balance recovery and evaluation in pediatrics OSPEDALE BAMBINO GESU' EST Integrative, Functional, and Cognitive 9,5 330.000 2303193 Individualized treatment of patients with advanced NSCLC: potential application for Circulating Tumor Cells (CTC) molecular and phenotypical profiling I. O. V. CLI ORD Oncology 2 9,5 332.400 204.600 Pagina 59 di 332

2309400 2320404 2310662 2316600 2315253 2319140 2317798 2319226 Corrected ipsc as therapeutic source for Spinal Muscular Atrophy Intrauterine growth restriction. and proteo metabolomic investigation. FEASIBILITY AND COST EFFECTIVENESS OF A MULTIDISCIPLINARY HOME TELEHEALTH INTERVENTION PROGRAMME TO REDUCE FALLS AMONG ELDERLY DISCHARGED FROM HOSPITAL: A PILOT RANDOMIZED CONTROLLED TRIAL Evaluation of a multidisciplinary team case management on clinical outcome in a tertiary traumatology centre. Role of squamous cell differentiation regulators in lung cancer. Molecular understanding of E3 ligases involved in signaling and cancer The neurobiology of social perception deficits in Autism Spectrum Disorders: simulation, integration and connectivity In vivo toxi omic signatures for brain and thyroid function: combined exposure to mixtures of endocrine disrupting chemicals and iodine deficiency in animal models and translation to epidemiological/clinical studies MAGGIORE ORD Molecular, Cellular, 9,5 348.000 and Developmental Veneto ORD Endocrinology, Metabolism, Nutrition and Reproductive 9,5 350.000 MAUGERI CLI ORD Risk, Prevention 9,5 360.000 157.900 and Health Behavior Toscana CLI ORD Healthcare Delivery 9,5 360.000 150.000 and Methodologies SDN EST Musculoskeletal, 9,5 360.000 Oral and Skin I.E.O. ORD Biological Chemistry and Macromolecular Biophysics 9,5 363.000 Abruzzo ORD Brain Disorders and 9,5 365.000 Istituto Superiore di Sanita' ORD Endocrinology, Metabolism, Nutrition and Reproductive 9,5 367.780 Pagina 60 di 332

2321735 Constitutive Axl signaling in human melanoma: role in tumor biology and in resistance to BRAFV600E inhibitors. ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 9,5 370.300 2316090 2318574 2319097 BASAL GANGLIA FUNCTIONAL ABNORMALITIES CORRELATING WITH GAIT DISTURBANCES IN PARKINSON S DISEASE. TOWARD NOVEL BRAIN SIGNAL CONTROLLED DEVICES FOR ADAPTIVE DEEP BRAIN STIMULATION Synthesis of new compounds with antiret activity and evaluation of their antineoplastic activity (in vitro and in vivo) in papillary and medullary thyroid cancer Strategies To Improve Human Cardiac Stem Cell Regenerative Capacity MAGGIORE ORD Brain Disorders and 9,5 381.400 Toscana ORD Oncology 2 9,5 390.000 Lazio ORD Cardiovascular and 9,5 400.000 Respiratory 2313040 Use of protective cultures of lactic acid bacteria to control colonizing mastitis pathogens in the mammary gland of dairy small ruminants as an alternative to antibiotics Istituto Zooprofilattico Sperimentale della Sardegna ORD Veterinary 9,5 400.000 320.400 (5) 2312484 2314903 2307465 Role of TIR8, a novel member of IL 1R/TLR family with a negative regulatory activity, in inflammation and cancer. Screening of children at risk for language and communication disorders Expression of PARP1 and LDOC1 genes in subjects with Down syndrome and identification of new markers of neurodegenerative disorders in these subjects. HUMANITAS ORD Immunology 9,5 400.000 Lazio CLI ORD Biobehavioral and 9,5 400.000 176.200 Behavioral Processes OASI MARIA S.S. ORD Interdisciplinary 9,5 400.000 Molecular and Training Pagina 61 di 332

2320968 Role of the master stroma regulator SPARC in myeloid cancer associated bone marrow failure. ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 9,5 401.500 2313520 A CORRELATIVE, NEUROIMMUNOVIROLOGICAL AND MRI ANALYSIS OF PROGNOSTIC MARKERS IN ALZHEIMER'S DISEASE DON GNOCCHI ORD Brain Disorders and 9,5 410.000 2312842 Dominant optic atrophy (DOA) and OPAopathies in Italy: prevalence, phenotypes, genes and functional studies towards a therapy Istituto Scienze Neurologiche ORD Brain Disorders and 9,5 425.000 2317320 2316458 Soluble biomarkers predicting coronary bypass graft patency Transcriptomic profiling in circulating mesenchymal stem cells of patients with degenerative diseases. MONZINO CLI ORD Surgical, Biomedical Imaging, and Bioengineering 9,5 427.900 301.100 Veneto ORD Genes, Genomes 9,5 437.000 and Genetics 2316659 Perturbed hydrogen sulphide content in Amyotrophic Lateral Sclerosis: a possible player in motor neurons degeneration? SANTA LUCIA ORD Brain Disorders and 9,5 440.000 2314680 Circulating tumor cells, with stem like and/or epithelial mesenchymal transition features, detectable in peripheral blood of breast cancer patients: biological and clinical significance ISTITUTO TUMORI MILANO ORD Oncology 2 9,5 444.756 2319262 2313794 New antimicrobial agents targeting antibiotic resistance mechanisms and novel or underexploited targets Cyclophilin A as a new therapeutic target for limb ischemia Marche ORD Infectious Diseases and Microbiology 9,5 450.000 MONZINO ORD Vascular and 9,5 451.000 Hematology Pagina 62 di 332

2319378 Quantitative assessment of spasticity: physiopathology and clinical application SANTA LUCIA CLI EST Biobehavioral and 9,5 454.000 Behavioral Processes 2316354 MOLECULAR TECHNIQUES FOR MONITORING THE RESPONSE TO THERAPY IN TUBERCULOSIS PATIENT SAN RAFFAELE MONTE TABOR ORD Infectious Diseases 9,5 456.500 and Microbiology 2321996 2317213 TISSUE PATCH ENGINEERING OF ADIPOSE DERIVED STEM CELLS FOR MEDICAL DEVICES. From observation to action in dementia prevention to identify prognostic and intervention monitoring tools based on non invasive multimarkers phenotypes MAGGIORE ORD Bioengineering 9,5 478.000 and Technologies Umbria ORD Biobehavioral and 9,5 486.200 Behavioral Processes 2308203 Sirt1 and Sirt2 as targets for the manipulation of the proliferative processes associated to physiopathologic conditions of the skin ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Musculoskeletal, 9,5 490.000 Oral and Skin 2320466 IDENTIFICATION OF PHENOTYPE MODULATOR VARIANTS IN LAMIN A/C MUTATION CARRIERS BY EXOME AND GENOME SEQUENCING SAN RAFFAELE MONTE TABOR ORD Genes, Genomes 9,5 492.000 and Genetics 2309087 Oxidative stress and microrna 125b : from molecular mechanisms to therapeutic implications in Hailey Hailey disease Istituto Superiore di Sanita' ORD Musculoskeletal, 9,5 495.000 Oral and Skin 2311299 Optimization of the clinical management of endocrine responsive early breast cancer patients IRCCS AOU San Martino IST (Genova) CLI ORD Oncology 2 9,5 495.000 348.900 2303925 Assessing the immunomodulatory effect of probiotics in the Experimental Model of Myasthenia Gravis CARLO BESTA EST Brain Disorders and 9,5 495.300 Pagina 63 di 332

2321561 2306890 2308510 Strategy of immunotherapy with specific T lymphocytes versus B cell acute lymphoblastic leukemia Role of Calcium/Calmodulin dependent Kinase Kinase 2 in metabolic stress and inflammatory response Prognostic utility of biological indicators in human colorectal cancer: the chemokine axis CX3CL1/CX3CR1 Piemonte ORD Oncology 2 9,5 500.000 SAN RAFFAELE PISANA ORD Immunology 9,5 510.500 HUMANITAS ORD Oncology 1 Basic 9,5 549.000 2314784 Food irradiation: quality and detection of plant origin food with health benefits Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata ORD Veterinary 9,5 550.000 311.300 (5) 2316592 Role of HIV p17 in EBV driven B cell lymphomagenesis C.R.O. AVIANO ORD Oncology 1 Basic 9,5 550.000 2315853 Understanding and enhancing the therapeutic effect of FTY720 (Fingolimod) in multiple sclerosis: a structural biology approach SAN RAFFAELE MONTE TABOR ORD Biological Chemistry and Macromolecular Biophysics 9,5 550.000 2314529 MOLECULAR PROFILING OF HEPARAN SULFATES IN M.O. PATIENTS: EVALUATION OF PATHOPHYSIOLOGICAL PATHWAYS TO DEFINE A COMPLETE CHEMICAL PROFILING FOR DIAGNOSIS AND PATIENTS FOLLOW UP. RIZZOLI ORD Biological Chemistry and Macromolecular Biophysics 9,5 554.000 2315446 Ageing at work: promoting health and safety of ageing workers according to changes of demography, labour market and social policies. MAGGIORE ORD Risk, Prevention 9,5 555.000 and Health Behavior 2314994 Neural Stem Cell mediated Therapy of Amyotrophic Lateral Sclerosis CASA SOLLIEVO SOFFERENZA ORD Brain Disorders and 9,5 556.600 Pagina 64 di 332

2314854 mtor substrate and microrna involvement in ALS: potential novel therapeutic perspectives and pathological markers. SANTA LUCIA ORD Brain Disorders and 9,5 560.000 2312646 Pathway Dissection In Leukocyte Migration: SAN RAFFAELE MONTE Identification And Validation Of Novel TABOR Therapeutic Targets In Nonresolving Inflammation ORD Immunology 9,5 562.000 2317292 Telemedicine Services for UTAP Veneto CLI ORD Healthcare Delivery 9,5 574.999 405.700 and Methodologies 2318525 A comprehensive strategy to eradicate prion diseases from the Italian sheep and goat population Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary 9,5 579.700 390.500 (5) 2306918 2312910 2318314 2312933 2321715 HUMAN ADIPOSE STEM CELLS AS A NOVEL TARGET FOR THERAPEUTIC INTERVENTION IN OBESITY Validation of molecular signatures in liver lesions as paradigm for discovery of new biomarkers and therapeutic targets Autoimmunity to PDGF receptor and DNA instability: a novel pathogenic mechanism with implications for new diagnostic and therapeutic tools in fibrotic diseases Epigenetic memory and impairment of human endothelial and mesenchymal progenitor activity by cardiovascular risk factors The role of Ambra1 mediated autophagy in the development and prognosis of gliomas. Toscana ORD Endocrinology, Metabolism, Nutrition and Reproductive 9,5 580.000 PASCALE CLI ORD Oncology 2 9,5 587.000 263.500 Marche EST Immunology 9,5 595.000 MONZINO ORD Cardiovascular and 9,5 595.900 Respiratory SANTA LUCIA ORD Oncology 1 Basic 9,5 596.200 Pagina 65 di 332

2304945 Molecular biomarkers and cellular biosensors of neurodegeneration SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 9,5 600.000 2312896 2310624 The role of epigenome in lamin disorders: higher order structures in time and space An integrated genomic and immunologic approach to novel strategies of monitoring and therapy for HBV and HCV infections SANTA LUCIA ORD Cell Biology 9,5 600.000 Emilia Romagna ORD Infectious Diseases 9,5 600.000 and Microbiology 2318774 Identification of prognostic and predictive serum biomarkers for monitoring type 1 diabetes risk and progression in humans Toscana ORD Immunology 9,5 600.000 2318000 The key role of serotonin in the pathophysiology of phenylketonuria: from bench to bedside OASI MARIA S.S. ORD Brain Disorders and 9,5 600.000 2317381 New molecular pathways involved in coronary and carotid atherosclerosis SAN RAFFAELE MONTE TABOR EST Vascular and 9,5 600.000 Hematology 2302573 EVALUATION OF THE SENSITIVITY AND SPECIFICITY OF DIFFERENT MEMORY TESTS FOR ALZHEIMER S DISEASE SAN RAFFAELE MONTE TABOR CLI EST Brain Disorders and 9,5 600.000 2308141 EXTENDING COMPREHENSIVE CANCER CENTERS EXPERTISE IN PATIENT EDUCATION: THE POWER OF PARTNERSHIP WITH PATIENT REPRESENTATIVES C.R.O. AVIANO CLI ORD Healthcare Delivery 9,6 290.000 175.200 and Methodologies 2318198 2311041 Prognostic marker of cytomegalovirus infection and transmission in pregnancy. ACTION OBSERVATION TREATMENT (AOT) IN MILD ALZHEIMER DISEASE: A RANDOMIZED CONTROLLED TRIAL. Emilia Romagna CLI ORD Infectious Diseases 9,67 250.000 150.000 and Microbiology Emilia Romagna CLI ORD Brain Disorders and 9,75 150.778 150.000 Pagina 66 di 332

2318891 Vitamin D and Myasthenia Gravis: from the animal model to the human disease CARLO BESTA ORD Brain Disorders and 9,75 255.500 2321248 Application of nanomechanical assays to detection of algal toxins Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary 9,75 380.000 2308399 2314518 CNF1 as a new therapeutic approach for the treatment of astrogliosis and neuroinflammation in Alzheimer's disease SENSITIZING GLIOBLASTOMA CELLS TO CHEMOTHERAPY BY PRO DIFFERENTIATING AGENTS Istituto Superiore di Sanita' ORD Brain Disorders and 9,75 500.000 Veneto ORD Oncology 1 Basic 9,75 506.000 2305532 A study on molecular characteristics of the gp120 Env protein from HIV 1 subtypes and recombinant forms circulating in Cameroon and their correlation with disease stage, virus infectivity and resistance to neutralization Istituto Superiore di Sanita' ORD AIDS and Related 9,75 550.000 Research 2312621 2312866 2309850 An innovative machine perfusion (Bologna machine perfusion) for abdominal organs preservation before transplantation. Optimization of perfusion, temperature and oxygenationrelated variables. An intervention aimed at improving the cognitive, physical, and psychiatric functioning of patients with Mild Cognitive Impairment: A randomized control trial of physical exercise and cognitive stimulation. Developmental Dyslexia Prevention: Magnocellular Dorsal Pathway Deficit Identification by Means of Visual Motion Illusions and Perceptual Learning Training Emilia Romagna ORD Surgical, Biomedical Imaging, and Bioengineering 9,75 600.000 Lazio CLI ORD Risk, Prevention 9,8 464.750 280.800 and Health Behavior MEDEA CLI ORD Brain Disorders and 10 122.000 Pagina 67 di 332

2310424 2303599 2315158 HPV INFECTION IN A COHORT OF HIV POSITIVE MEN AND WOMEN: VIRO IMMUNOLOGICAL CORRELATES OF HPV DISEASE PROGRESSION AT GENITAL AND ORAL SITES Non invasive diagnosis on non alcoholic steatohepatitis and of significant/severe fibrosis among patients with non alcoholic fatty liver disease. Short term effects of the implementation of the NIDCAP model for very low birth weight babies Lombardia CLI ORD AIDS and Related 10 137.564 Research Sicilia CLI ORD Digestive, Kidney 10 150.000 and Urological Systems Emilia Romagna CLI ORD Healthcare Delivery 10 150.000 and Methodologies 2304029 Risk of obstetric and thromboembolic complications in family members of women with previous adverse obstetric outcomes carrying inherited thombophilias. A family study CASA SOLLIEVO SOFFERENZA ORD Population 10 150.000 and Epidemiology 2315404 2320046 2315142 EFFECT OF DEACETILASE INHIBITORS ON EPIGENETIC BALANCE OF E CADHERIN: NEW TOOLS TO CONTROL LOCAL INVASION AND METASTASIS OF ENDOCRINE RELATED TUMORS Gastro intestinal bacteria, obesity and insulin resistance. Development of brain targeted epigenetic drugs for the treatment of neurodegenerative disorders and brain ischemia Piemonte ORD Oncology 1 Basic 10 150.000 Emilia Romagna ORD Endocrinology, Metabolism, Nutrition and Reproductive 10 150.000 S.CAMILLO COF Brain Disorders and 10 150.000 150.000 Pagina 68 di 332

2309791 2317872 2315445 2318579 2311898 2315054 SURVEILLANCE OF MULTI DRUG RESISTANT (MDR) MICRO ORGANISM AND FUNGI COLONIZATION AND INFECTIONS ACQUIRED IN A NOSOCOMIAL SETTING, WITH PARTICULAR REFERENCE TO SURGICAL INFECTIONS IN CANCER PATIENTS AND EMERGENCY SURGERY PATIENTS. Telemedicine in cardiology:training of a virtual team Phenotypes in Dislexia with genetic alteration: sensory and neuronal deficits Development of a specific comorbidity index to improve the management of elderly MDS/AML patients Identification of novel determinants of therapeutic response to targeted therapies and of new druggable driver oncoproteins in patientderived xenografts from primary HER2 positive and triple negative breast cancers. Identification of early neurophysiological markers of cognitive behavioural disturbances in patients with cerebrovascular disease. Sicilia CLI EST Risk, Prevention 10 150.000 and Health Behavior SAN RAFFAELE PISANA CLI ORD Healthcare Delivery 10 165.000 and Methodologies STELLA MARIS CLI ORD Integrative, Functional, and Cognitive 10 165.000 Piemonte CLI ORD Population 10 165.000 and Epidemiology Piemonte ORD Oncology 2 10 200.000 Sicilia CLI ORD Brain Disorders and 10 200.000 2315837 Evaluation of the effect of testosterone replacement therapy (TRT) on prostatic gland in Toscana CLI ORD Endocrinology, Metabolism, 10 200.000 hypogonadal patients affected by benign prostatic Nutrition and Reproductive hyperplasia (BPH) and metabolic syndrome (MetS) 2312281 Biomarkers and prognostic factors in psoriasis and psoriatic arthritis: a prospective cohort study Lombardia CLI ORD Musculoskeletal, 10 200.000 Oral and Skin Pagina 69 di 332

2313702 2317950 Impact of diet in shaping gut microbiota revealed by a prospective dietetic study of African children consuming a Western diet Heart remodelling in Chronic Obstructive Pulmonary Disease: diagnostic and therapeutic implications DE BELLIS CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 10 202.500 Emilia Romagna ORD Cardiovascular and 10 210.100 Respiratory 2306177 Transplantation of Human Amniotic Membrane Derived Mesenchymal Stem Cells (hamscs) for Hepatic Regeneration and Reduction of Fibrosis in Rats with Decompensated Cirrhosis Sicilia ORD Digestive, Kidney 10 220.000 and Urological Systems 2311002 2320726 2312270 A scoring system to predict the risk of developing post operative atrial fibrillation Heparin derivatives to regulate hepcidin expression and iron homeostasis Preclinical characterization of a potent antimicrobial peptide for the development of a new drug for Cystic Fibrosis Istituto Superiore di Sanita' ORD Cardiovascular and Respiratory 10 240.000 FATEBENEFRATELLI ORD Vascular and 10 250.000 Hematology Toscana ORD Infectious Diseases 10 250.000 and Microbiology 2316322 Role of functional and morphological MRI in the study of thalamus and auditory cortex for the assessment of the neurocognitive and clinical outcomes of premature newborns SAN RAFFAELE MONTE TABOR CLI ORD Brain Disorders and 10 250.000 2308024 Amelioration of diagnosis and therapy of steroid resistant nephrotic syndrome: a novel treatment approach by umbilical cord blood mesenchymal stem cells. MAGGIORE CLI ORD Digestive, Kidney 10 250.000 and Urological Systems Pagina 70 di 332

2311159 2310395 2314193 EMERGING NOROVIRUS MUTANT AND RECOMBINANT STRAINS: A MOLECULAR EPIDEMIOLOGICAL INVESTIGATION ON SEWER SYSTEMS AND HOSPITALIZED PATIENTS Target definition of tumors in positron emission tomography: development and validation of a software tool to be installed on radiotherapy treatment planning systems Cost Utility of Conventional Hemodialysis (CHD) versus Short Daily Hemodialysis (SDHD) for patients coming from Automated Peritoneal Dialysis (APD): A randomized controlled trial Istituto Superiore di Sanita' ORD Infectious Diseases 10 250.000 and Microbiology Piemonte ORD Oncology 2 10 250.000 Puglia CLI COF Healthcare Delivery 10 260.000 150.000 and Methodologies 2315375 Development and therapeutic potential evaluation of L glutamate and kynurenic acid analogues in an animal model of meningococcal meningitis. SDN ORD Infectious Diseases 10 270.000 and Microbiology 2319169 DOMoRIS Diabetes and Obesity Monitoring and Rehabilitation Integrated System AUXOLOGICO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 10 280.000 2305558 Evaluation of oxidative stress and inflammation in blood as possible non invasive markers for progression of alcoholic liver disease. IRCCS AOU San Martino IST (Genova) ORD Digestive, Kidney 10 280.000 and Urological Systems 2321532 2321956 MicroRNAs as potential therapeutic strategies to prevent adverse vascular events and increase angiogenesis after limb ischemia. INVESTIGATING THE ROLE OF THE CERULOPLASMIN/TRANSFERRIN SYSTEM IN THE PHYSIOPATHOLOGY OF HEPATIC ENCEPHALOPATHY. Calabria ORD Cardiovascular and 10 282.000 Respiratory SAN RAFFAELE PISANA ORD Brain Disorders and 10 289.000 Pagina 71 di 332

2308949 2315725 Aphasia. Theory for therapy. Therapy for theory. S.CAMILLO CLI ORD Brain Disorders and 10 290.000 Spatiotemporal organization of motoneuronal activity in the spinal cord in children with cerebral palsy SANTA LUCIA ORD Integrative, Functional, and Cognitive 10 294.360 2321487 2319471 2315664 2313990 2318718 Autoimmune encephalopaties: better characterization of the antibody profile MARKERS TRANSLATIONAL PROGRAM IN THE ANTIANGIOGENIC TREATMENT OF COLORECTAL CANCER WITH BEVACIZUMAB Molecular characterization of glioblastoma stem cell contribution to tumor vascularization to design novel therapies for glioblastoma treatment Identification of micrornas as novel therapautic targets and biomarkers for the advancement of anti cancer strategies of human hepatocellular carcinoma Protective role of HspB8 in motor neuron diseases (MNDs) CARLO BESTA CLI ORD Brain Disorders and 10 297.200 Toscana ORD Oncology 2 10 300.000 Istituto Superiore di Sanita' ORD Oncology 1 Basic 10 300.000 Emilia Romagna ORD Oncology 2 10 300.000 MONDINO ORD Molecular, Cellular, 10 300.000 and Developmental 2309152 2301285 Pentraxin 3 as a predictive biomarker of NEUROMED CLI ORD Brain Disorders and 10 300.000 hemorrhagic transformation following acute stroke Steroid myopathy: pathogenies and prevention MAUGERI ORD Musculoskeletal, 10 300.000 Oral and Skin Pagina 72 di 332

2320665 Cancer biomarker detection using microstructured/super hydrophobic surfaces and advanced spectroscopy techniques Calabria COF Bioengineering 10 300.000 181.300 and Technologies 2317349 Role of SAMITAL in prevention of chemoradiation (CT/RT) induced oral mucositis in cancer patients. A Phase 2 Randomized Controlled trial in adults and a feasibility study in paediatric patients I. O. V. CLI COF Oncology 2 10 300.000 181.300 2319509 Etiopathogenetic, diagnostic and prognostic role of hypermethylation and downregulation of IRX1 gene inducedby H. pylori infection in patients with gastric cancer. SAN RAFFAELE MONTE TABOR CLI ORD Oncology 2 10 312.775 2320716 Innovative procedures for Transcranial Magnetic Stimulation of neuro patients, also in vegetative state NEUROLESI ORD Surgical, Biomedical Imaging, and Bioengineering 10 317.000 2306199 NOVEL AND SELECTIVE ANTI TUMOR STRATEGIES FOR THE TREATMENT OF GLIOMA ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Brain Disorders and 10 330.000 2309827 2308445 2312031 2316968 The clinical significance of the association between REM Sleep Behavior Disorder and Parkinson s Disease Implementation of a fracture liaison service for the identification, evaluation and management of patients with osteoporotic fractures Cell stress mediators in cancer stroma interaction as targets for drug development CHARACTERIZATION OF NEW MOLECULAR MECHANISMS CONTROLLING INVASIVENESS IN THYROID TUMORS OASI MARIA S.S. ORD Brain Disorders and 10 350.000 Toscana CLI ORD Healthcare Delivery 10 360.000 and Methodologies SDN ORD Oncology 1 Basic 10 368.000 ARCISPEDALE ORD Oncology 1 Basic 10 380.000 Pagina 73 di 332

2306967 2312166 2312060 2317533 2313020 2303391 2321606 2319584 GENETIC REGULATION OF PLASMA LOW DENSITY LIPOPROTEIN LEVELS.EFFECT OF MUTATIONS OF APOB AND ANGPTL3 GENES ON HEPATIC SECRETION OF APOB CONTAINING LIPOPROTEINS. Validation of the micronucleus assay in buccal exfoliated cells as a tool for biomonitoring DNA damage in human populations and predicting cancer, cardiovascular diseases and neurodegenerative disorders in healthy subjects. Expression profile and risk haplotypes identification in peripheral blood of stroke patients with carotid atherosclerotic plaques AUTOLOGOUS BONE MARROW DERIVED STEM CELL TRANSPLANTATION FOR TREATMENT OF CHRONIC END STAGE LIVER DISEASE (ESLD) Exploring the effects of different intensity and frequency of robotic gait training in patients affected by a severe stroke in subacute phase In vivo identification of molecular determinants critical to the metastatic process in melanoma CANNABINOID AND GLUCOCORTICOID INTERACTION: A POSSIBLE BRIDGE OVER TROUBLED DISEASES Amniotic stem cells to improve congenital kidney damage: a fetal lamb model Emilia Romagna ORD Cardiovascular and 10 380.000 Respiratory SAN RAFFAELE PISANA ORD Population 10 394.000 and Epidemiology Veneto ORD Genes, Genomes 10 400.000 and Genetics Emilia Romagna CLI ORD Digestive, Kidney 10 400.000 and Urological Systems SANTA LUCIA CLI ORD Brain Disorders and 10 400.000 I.E.O. ORD Oncology 1 Basic 10 400.000 SANTA LUCIA ORD Brain Disorders and 10 400.000 SAN MATTEO ORD Digestive, Kidney 10 400.000 and Urological Systems Pagina 74 di 332

2318457 Susceptibility to heat in cohorts of births, children and elderly: a multi centric study to identify shortterm effects of heat, effect modifiers and to study long term exposure effects over a ten year period Lazio EST Population 10 400.000 and Epidemiology 2318215 2313013 2309175 2308150 2306770 2316632 2312033 Assessment of the diagnostic value of novel salivary and lachrymal biomarkers for the early non invasive diagnosis of primary Sjögren s syndrome The modulation of T helper cell death as therapeutic approach to reduce the pathogenic cells in Multiple Sclerosis (MS). Efficacy of re treatment with anti TNF biologics in patients with psoriasis who have been previously treated with the same biological drug Short and long term effects of ART in restoring intestinal mucosal immunity and reducing systemic immune activation in HIV infected patients. Development of a prognostic tool based on a systems biology approach to identify new predictive markers of the evolution of different diseases TIPS FOR DECOMPENSATED CIRRHOSIS: A RANDOMIZED CLINICAL TRIAL SMALL PEPTIDES AS A NEW STRATEGY FOR THE THERAPY OF CELIAC DISEASE Toscana EST Musculoskeletal, 10 405.000 Oral and Skin SANTA LUCIA CLI ORD Brain Disorders and 10 420.000 SAN GALLICANO ORD Musculoskeletal, 10 420.000 Oral and Skin Istituto Superiore di Sanita' ORD AIDS and Related 10 420.000 Research PASCALE ORD Oncology 2 10 435.000 Sicilia CLI ORD Surgical, Biomedical Imaging, and Bioengineering 10 443.000 Istituto Superiore di Sanita' ORD Digestive, Kidney 10 450.000 and Urological Systems Pagina 75 di 332

2305497 2304615 In vivo analysis of the interactions between exogenouly administred mesenchymal stromal cells and primary acute leukemia cells or leukemia initiating cells growing in NOG mice: implications for selective delivery of anti cancer drugs to leukemic niches The Patatin like phospholipase domaincontaining3 (PNPLA3) I148M polymorphism in the recurrence of chronic hepatitis C after liver transplantation GASLINI ORD Oncology 1 Basic 10 450.000 MAGGIORE CLI ORD Digestive, Kidney 10 450.000 and Urological Systems 2319391 Comprehensive analysis for identification of prognostic and predictive epigenetic signature in Renal Cell Carcinoma REGINA ELENA EST Oncology 1 Basic 10 450.000 2309046 Isolation, characterization and pre clinical evaluation of cell derived microparticles as therapeutic tools in immunological and genetic disorders. OSPEDALE BAMBINO GESU' ORD Cell Biology 10 451.500 2305129 2300648 Hydrogel Mesoangioblast combination therapeutic approach to ameliorate cell therapy effect on muscle dystrophy treatment. Obesity and inflammation: new mechanistic insights from whole exome sequencing and analysis of microrna regulation by polyphenols. SANTA LUCIA ORD Musculoskeletal, 10 460.000 Oral and Skin Istituto Superiore di Sanita' ORD Endocrinology, Metabolism, Nutrition and Reproductive 10 490.000 2312990 Role of HIF factors in leukemogenesis and evaluation of the effectiveness of their targeting as anti leukemia therapy SAN RAFFAELE MONTE TABOR EST Oncology 1 Basic 10 490.000 2314687 Comparative effectiveness of AVR and TAVI procedures for severe symptomatic aortic stenosis treatment: results from the real world Istituto Superiore di Sanita' CLI ORD Healthcare Delivery 10 500.000 and Methodologies Pagina 76 di 332

2315654 How innate immunity enhances aggressiveness of colorectal carcinoma in HIV individuals SAN RAFFAELE MONTE TABOR ORD AIDS and Related 10 500.000 Research 2317446 PLERIXAFOR MOBILIZED HEMATOPOIETIC STEM CELLS: AN ALTERNATIVE STEM CELL SOURCE FOR GENE THERAPY OF BETA THALASSEMIA SAN RAFFAELE MONTE TABOR ORD Vascular and 10 500.000 Hematology 2318933 Identification of prognostic markers in advanced ovarian cancer by combining in vivo imaging with clinical and molecular data Lombardia CLI ORD Oncology 2 10 500.000 2313804 Preemptive donor lymphocyte infusions guided by real time PCR host donor microchimerism for prevention of leukemia relapse after haploidentical stem cell transplantation SAN RAFFAELE MONTE TABOR CLI ORD Oncology 2 10 500.000 2302599 2306978 2308119 Targeting Histone Acetylation as a Approach to Cancer Therapy Lysophosphatidic acid (LPA) as a lipid modulator of tumor/stroma cross talk during HCC tumor progression Identification of candidate modifier and causal genes for Multiple Osteochondromas by genomewide SNP/CNV genotyping REGINA ELENA EST Oncology 2 10 500.000 ONCOLOGICO DI BARI EST Oncology 1 Basic 10 500.000 RIZZOLI ORD Genes, Genomes 10 507.200 and Genetics 2313612 Thematic network on Bovine Diarrhoea Virus (BVDV) to improve tools and strategies for BVDV control in Italy Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary 10 520.000 2305443 Non invasive stimulation of cerebello thalamocortical circuits in dystonic patients SANTA LUCIA CLI ORD Brain Disorders and 10 520.000 Pagina 77 di 332

2303378 Novel formula milks and neonatal gut microbiota: a dynamic interplay approached by systems biology OSPEDALE BAMBINO GESU' ORD Endocrinology, Metabolism, Nutrition and Reproductive 10 523.000 2309427 Study of pro inflammatory/anti inflammatory balance in Frontotemporal lobar degeneration FATEBENEFRATELLI ORD Brain Disorders and 10 525.000 2311409 WNT signaling in the pathogenesis and treatment of Bipolar Disorder SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 10 528.000 2316539 Neurophysiological markers of neuroplasticity in normal and pathological aging FATEBENEFRATELLI ORD Brain Disorders and 10 531.300 2317527 A new approach to diagnosis in muscular diseases CARLO BESTA EST Genes, Genomes 10 532.550 and Genetics 2312570 2317020 2321154 2320179 Toward a molecular criterium for the diagnosis of multiple Sclerosis.A proteomic and redox proteomic study Imaging and radioimmunotherapy of pancreatic cancer HOME BASED COGNITIVE REHABILITATION AFTER BRAIN DAMAGE THROUGH VIRTUAL REALITY Novel tools for evaluation of Type A aortic dissection: from bedside to bench, and back REGINA ELENA ORD Brain Disorders and 10 538.500 I. O. V. ORD Surgical, Biomedical Imaging, and Bioengineering 10 539.900 Lombardia CLI ORD Brain Disorders and 10 549.776 NEUROMED CLI ORD Surgical, Biomedical Imaging, and Bioengineering 10 550.000 Pagina 78 di 332

2305090 MELANOMA TARGETING MULTIFUNCTIONAL NANOPARTICLES FOR THERAGNOSTIC APPLICATIONS ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Bioengineering 10 550.000 and Technologies 2317993 2316030 A new automatic device for personalized clinical monitoring of thrombotic and hemorraghic risk assessment in cancer patients Research Strategies for Treatment of Acute Neurodegenerative Disorders C.R.O. AVIANO COF Oncology 2 10 565.000 342.200 CARLO BESTA EST Brain Disorders and 10 566.500 2301319 A new therapeutic window in neurorehabilitation FATEBENEFRATELLI ORD Biobehavioral and 10 572.500 Behavioral Processes 2314705 Can epilepsy affect the structure of the brain? Role of neurons and glia and effect of therapy in a model of epileptogenic brain malformation CARLO BESTA ORD Brain Disorders and 10 575.000 2319384 Developing innovative methods for detecting emerging food allergens and evaluation of their impact on consumer health: an integrated approach.integrall Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary 10 580.000 344.800 (5) 2312943 A look into the intricate network of myospryn HUMANITAS ORD Cardiovascular and 10 580.000 Respiratory 2313511 2320516 Synapsin phosphorylation by PKA and Erk: role in learning related synaptic plasticity and schizophrenia related dopaminergic dysfunction MicroRNAs as molecular markers of susceptibility to Mycobacterium tuberculosis infection and responsiveness to vaccination in IRF 8 deficient mouse model FATEBENEFRATELLI ORD Molecular, Cellular, 10 588.000 and Developmental Istituto Superiore di Sanita' ORD Infectious Diseases 10 594.000 and Microbiology Pagina 79 di 332

2306686 Effects of cognitive and aerobic training on cognitive performances and the resting state brain activity in aging individuals Abruzzo EST Biobehavioral and 10 594.000 Behavioral Processes 2301643 2318575 Pre clinical evaluation of safety and efficacy of intra arterial infusion of mesenchymal stems cells in experimental models of neurodegenerative parkinsonisms and analysis of potential therapeutic mechanisms: en route for a clinical trial Targeting Sarcomas and Their Progenitors by Mesenchymal Stromal/Stem Cells Based Drug Delivery MONDINO ORD Brain Disorders and 10 595.000 Emilia Romagna ORD Oncology 2 10 599.250 2314110 Adoptive therapy with tolerogenic T regulatory type 1 (Tr1) cells in islet transplanted T1D patients SAN RAFFAELE MONTE TABOR ORD Immunology 10 600.000 2319631 Targeting Hedgehog and Colony Stimulating Factor 1 pathways in triple negative breast cancers Toscana ORD Oncology 2 10 600.000 2313917 Hypothesized points of convergence in the pathogenesis of Alzheimer's disease, frontotemporal lobar dementia, schizophrenia and bipolar disorder with therapeutic implications SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 10 600.000 2312652 2315336 Leptin, metabolic state and natural regulatory T cells: cellular and molecular basis for a novel immune intervention in multiple sclerosis Increased severity of repiratory viral infections in the elderly: identification of thiol levels as biomarker and therapeutic target. SANTA LUCIA CLI ORD Immunology 10 600.000 SAN RAFFAELE PISANA ORD Infectious Diseases 10 600.000 and Microbiology Pagina 80 di 332

2308140 WHOLE EXOME SEQUENCING TO IMPROVE DIAGNOSTIC, PROGNOSTIC AND LOGICAL CHARACTERIZATION OF AML WITH NORMAL KARYOTYPE Umbria ORD Vascular and 10 600.000 Hematology 2310012 Structural and functional large scale brain networks across multiple sclerosis clinical phenotypes: a graph theory approach to identify neuronal system vulnerability as a target of future therapeutic interventions SAN RAFFAELE MONTE TABOR CLI ORD Brain Disorders and 10 600.000 2312634 mirna driven conditional attenuation of viral vaccines SAN RAFFAELE MONTE TABOR ORD Infectious Diseases 10 600.000 and Microbiology 2308279 2314482 2319063 2308483 2308348 2321720 Characterization of post translational modifications of Polycomb Group proteins in differentiation, senescence ad cancer RESPONSE ORIENTED MAINTENANCE IMMUNOTHERAPY IN PATIENTS WITH FOLLICULAR LYMPHOMA. The role of enos in neoplastic progression induced by chronic stress. Development and optimization of a dedicated selfshielded system to perform accelerated partial breast irradiation in prone position after breast conserving surgery. THE GASTRIC SUBMUCOSAL SPACE(GSMS) AS A SITE FOR ISLET ALLOTRANSPLANTATION WITH THE USE OF ALEMTUZUMAB Molecular mechanisms involved in leukocyte recruitment in cerebral vessels and in the pathogenesis of seizures and epilepsy I.E.O. ORD Genes, Genomes 10 600.000 and Genetics Emilia Romagna CLI ORD Oncology 2 10 600.000 PASCALE EST Oncology 1 Basic 10 600.000 REGINA ELENA CLI COF Oncology 2 10 600.000 363.100 Sicilia EST Endocrinology, Metabolism, Nutrition and Reproductive 10 600.000 NEUROLESI ORD Brain Disorders and 10 650.000 Pagina 81 di 332

2321548 2317164 2320021 Use of polydeoxyribonucleotide for treating diabetic foot ulcers Prospective multicenter study on the efficacy of a new, taylored on risk class, antibiotic prophylaxis protocol in preventing neurosurgical Surgical Site Infection (SSIs). Human Cytomegalovirus (HCMV) specific T cell immunity monitoring and inflammatory response analysis in solid organ transplant recipients: from pathogenesis to clinical application Sicilia ORD Endocrinology, Metabolism, Nutrition and Reproductive 10,17 350.000 Lombardia CLI ORD Infectious Diseases 10,25 150.000 and Microbiology Toscana CLI ORD Infectious Diseases 10,25 289.000 and Microbiology 2318550 SERUM AUTOANTIBODIES TO LGI1 AND OTHER CELL SURFACE MEMBRANE PROTEINS IN TEMPORAL LOBE EPILEPSIES OF OTHERWISE UNKNOWN AETIOLOGY Istituto Scienze Neurologiche ORD Brain Disorders and 10,25 300.000 2314617 2312117 2319585 2321072 Studying the tumour microenvironment to find new therapeutic targets and strategies in Hodgkin lymphoma: the role of Mesenchymal stem cells Allergy management based on the neonatal risk: a technological pathway. Prevalence of Neonatal Adverse Outcomes and Their Risk Factors and Study on Adverse Medication Effects on the Newborn Health. Neurophysiological and functional connectivity markers of fluctuating cognition and attention disorders in Dementia with Lewy Bodies and Parkinson s Disease with Dementia C.R.O. AVIANO ORD Oncology 1 Basic 10,25 310.000 SAN MATTEO ORD Risk, Prevention 10,25 325.000 and Health Behavior Veneto CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 10,25 329.000 NEUROLESI EST Brain Disorders and 10,25 400.000 Pagina 82 di 332

2317095 Assessing antibiotic resistance in nonpathogenic food related bacteria: the impact on human gut microbiota Istituto Zooprofilattico Sperimentale delle Venezie ORD Veterinary 10,25 558.600 344.800 (5) 2310899 Campylobacter, L. monocytogenes and Verocytotoxin producing E. coli (VTEC) in Italy: a molecular epidemiology approach to identify sources of infection and risk factors for human exposure Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise ORD Veterinary 10,25 580.000 344.800 (5) 2309944 Urine proteome analysis: A possible method that may allow noninvasive differential diagnosis of diabetic nephropathy and give new insight into monogenic type 2 diabetes. OSPEDALE BAMBINO GESU' ORD Digestive, Kidney 10,34 352.000 and Urological Systems 2317929 2318665 2312867 2306178 2311203 The effect of pulmonary rehabilitation on the reduction of acute exacerbations in patients with COPD. The impact of inflammatory phenotype Proposal for a multidisciplinary integrated approach to the health management of myotonic dystrophy type 1 (DM1) New methodologies for non invasive, quantitative and Automatic MOnitoring of childbirth LABor (AMOLAB) Docetaxel, Cisplatin and 5 Fluorouracil followed by concomitant Radiotherapy and PF299804 in Locally advanced Head and Neck carcinoma: A phase II study proposal A new approach to study the genetic basis of sporadic non syndromic mental retardation with next generation technologies DON GNOCCHI CLI ORD Cardiovascular and 10,34 387.000 Respiratory SAN RAFFAELE PISANA CLI ORD Healthcare Delivery 10,34 450.000 and Methodologies Puglia ORD Surgical, Biomedical Imaging, and Bioengineering 10,34 597.000 Lombardia CLI COF Oncology 2 10,5 120.000 (1) BURLO GAROFALO ORD Genes, Genomes 10,5 146.000 and Genetics Pagina 83 di 332

2315208 PRIMARY CILIUM, NPC1 AND PATCHED1 PROTEINS, AND CERAMIDE IN NIEMANN PICK TYPE C DISEASE Toscana ORD Brain Disorders and 10,5 150.000 2307091 2309961 2319721 ECHOCARDIOGRAPHIC EPICARDIAL FAT THICKNESS AS NEW PREDICTIVE MARKER OF CARDIOVASCULAR EVENTS AND CARDIAC REMODELLING Driving Neuronal Recycling in Developmental Dyslexia. Toward a Neuro Psycho Educational approach to differentiate rehabilitation strategies according to different neuro functional profiles of dyslexic children. Whole exome approach to identify the gene responsible for a novel condition associating severe mental retardation with skeletal dysplasia (SEMD Mental Retardation) SAN DONATO CLI EST Endocrinology, Metabolism, Nutrition and Reproductive 10,5 150.000 STELLA MARIS CLI ORD Brain Disorders and 10,5 180.000 ARCISPEDALE EST Genes, Genomes 10,5 184.100 and Genetics 2310774 IN VITRO GENERATION OF HEMOGENIC ENDOTHELIUM FROM HUMAN CORD BLOOD: A NEW TOOL FOR STUDYING THE DEVELOPMENT OF THE HEMATOPOIETIC SYSTEM AND FOR REGENERATIVE MEDICINE Istituto Superiore di Sanita' ORD Cell Biology 10,5 200.000 2307938 2317835 Structural analysis of nucleophosmin as a target for acute myeloid leukemia treatment Prognostic role of serum pro PSA, circulating tumor cells and serum testosterone levels in prostate cancer patients with biochemical progression undergoing androgen deprivation therapy Abruzzo ORD Biological Chemistry and Macromolecular Biophysics 10,5 210.000 Piemonte CLI ORD Oncology 2 10,5 220.000 Pagina 84 di 332

2305898 Role of Toll like receptors in chemoresistance of chronic lymphocytic leukemia SAN RAFFAELE MONTE TABOR ORD Immunology 10,5 225.000 2320421 2319841 Role of the intermediate conductance Caactivated K channels in glioblastoma induced angiogenesis THE ROLE OF SOD1 IN THE NUCLEUS: NEW INSIGHTS INTO THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS Umbria ORD Oncology 1 Basic 10,5 230.000 MONDINO ORD Molecular, Cellular, 10,5 230.000 and Developmental 2316441 Validation of a prognostic multigene classifier for larynx carcinoma, application to fine needle biopsies and functional analyses of classifier genes IRCCS AOU San Martino IST (Genova) CLI ORD Oncology 2 10,5 240.000 2320443 2321903 2314187 Real time fmri based motor imagery in chronic post stroke patients: randomized clinical trial of efficacy. Juvenile osteoporosis in patients with autoimmune thyroiditis: an observational study IMPLEMENTATION AND TESTING OF AN E HEALTH BASED SYSTEM FOR EARLY DIAGNOSIS AND INTERVENTION ON SPECIFIC READING DISORDERS STELLA MARIS CLI ORD Emerging Technologies and Training in s 10,5 240.000 Emilia Romagna CLI ORD Musculoskeletal, 10,5 250.000 Oral and Skin MEDEA CLI ORD Healthcare Delivery 10,5 250.000 and Methodologies 2312560 Telemonitoring in Heart Failure Liguria CLI ORD Bioengineering 10,5 255.500 and Technologies 2312394 Pilot study of a combination of an mtor inhibitor (everolimus) and capecitabine administered with a metronomic schedule in patients undergoing liver transplantation for hepatocellular carcinoma at high risk of recurrence. Emilia Romagna CLI ORD Oncology 2 10,5 260.000 Pagina 85 di 332

2315778 2318757 Bilateral sequential lung and pancreas transplantation and combined en bloc liverpancreas transplantation in patients with cystic fibrosis DOSE WARPING METHODS FOR IGRT AND ADAPTIVE RT: DOSE ACCUMULATION BASED ON ORGAN MOTION AND ANATOMICAL VARIATIONS OF THE PATIENTS DURING RADIATION THERAPY TREATMENTS Lombardia CLI ORD Surgical, Biomedical Imaging, and Bioengineering 10,5 261.500 Emilia Romagna COF Oncology 2 10,5 270.000 189.400 2315184 Molecular determination of Salmonella serovars by using microsphere based suspension array Istituto Zooprofilattico Sperimentale delle Venezie ORD Veterinary 10,5 274.200 179.200 (5) 2304391 Patient specific Induced Pluripotent Stem Cells (ipscs) to model neurodegeneration and to test gene therapy approaches in Lysosomal Storage Disorders (LSDs). SAN RAFFAELE MONTE TABOR ORD Genes, Genomes 10,5 275.000 and Genetics 2321466 2314786 2320438 2306592 2308269 Observational research: Psychological follow up in living donation process. AN INNERVATED TISSUE ENGINEERING APPROACH TO RECONSTRUCT THE ESOPHAGUS An open source computer package for estimating the burden of cancer disease using a Bayesian back calculation approach. The adenosine receptors: potential targets for diagnosis, prognosis and therapy of cancer A population genetics approach to identify novel susceptibility alleles for chronic inflammatory conditions: application to multiple sclerosis and inflammatory bowel disease Veneto CLI ORD Risk, Prevention 10,5 290.000 and Health Behavior Veneto ORD Surgical, Biomedical Imaging, and Bioengineering 10,5 296.955 Toscana ORD Healthcare Delivery 10,5 300.000 and Methodologies Emilia Romagna ORD Oncology 2 10,5 300.000 MEDEA ORD Genes, Genomes 10,5 300.000 and Genetics Pagina 86 di 332

2317510 2316572 Dermatological complications from metals and metal oxide nanoparticles (MONp) contained in tattoos: a population based study EXOME RESEQUENCING IN UNEXPLAINED RARE BLEEDING DISORDERS Istituto Superiore di Sanita' ORD Healthcare Delivery and Methodologies 10,5 300.000 MAGGIORE ORD Genes, Genomes 10,5 300.000 and Genetics 2304956 Macrophage polarization and HIV infection. A model of multiple restrictions of the virus life cycle. SAN RAFFAELE MONTE TABOR ORD AIDS and Related 10,5 300.000 Research 2314258 2314622 ß amyloid control of peripheral and neuronal glucose uptake DOPAMINERGIC MODULATION OF TONIC GABAA INHBITION: PATHOPHYSIOLOGICAL AND THERAPEUTIC IMPLICATIONS FOR ABSENCE SEIZURES NEUROMED COF Brain Disorders and 10,5 300.000 210.700 NEUROMED EST Brain Disorders and 10,5 300.000 2310079 "In vivo" characterization of anti podocyte antibodies in auto immune glomerulonephritis. Pathogenetic implication and validation as clinical bio markers GASLINI ORD Digestive, Kidney 10,5 304.560 and Urological Systems 2320880 2317209 2311337 A study on the economic and social burden of Parkinson s Disease in Italy and a cost benefit analysis of disease modifying therapies. Italian Network for congenital myasthenic syndromes: from diagnosis to functional in vivo and in vitro studies for clinical applications Simultaneous inhibition of PARP and homologous recombination: a new hypothesis for radiosensitization SAN RAFFAELE PISANA CLI ORD Healthcare Delivery 10,5 320.000 and Methodologies CARLO BESTA ORD Musculoskeletal, 10,5 326.100 Oral and Skin ONCOLOGICO DI BARI ORD Oncology 2 10,5 337.050 Pagina 87 di 332

2313672 2317534 2310496 NEW MOLECULES AS DISEASE MODIFYING DRUGS FOR OSTEOARTHRITIS TREATMENT Acid sphingomyelinase in melanoma development and progression Comparative analysis of the leukemia associated fusion proteins TEL/AML1 and AML1/ETO. Istituto Superiore di Sanita' ORD Musculoskeletal, 10,5 350.000 Oral and Skin Lombardia ORD Oncology 1 Basic 10,5 360.000 I.E.O. ORD Vascular and 10,5 362.000 Hematology 2311608 An integrated analytical, in vivo and in vitro approach to characterize polybrominated diphenyl ethers (PBDEs) in italian mussels: a basis for a Toxic Equivalent Factors (TEF) proposal. Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary 10,5 366.000 239.200 (5) 2303474 2320235 Insight into molecular events involved in the cooperation between bcl 2/bcl xl and hypoxia in the regulation of tumor progression and angiogenesis GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS AS A DRUGGABLE TARGET TO DEVELOP A PHARMACOLOGICAL STRATEGY IN ALEXANDER DISEASE REGINA ELENA ORD Oncology 1 Basic 10,5 380.000 GASLINI ORD Genes, Genomes 10,5 380.000 and Genetics 2319680 Investigation of a novel engineered probiotic to treat Clostridium difficile infection SAN RAFFAELE MONTE TABOR ORD Infectious Diseases 10,5 390.000 and Microbiology 2312922 Environmental factors and epigenomics in primary biliary cirrhosis HUMANITAS ORD Genes, Genomes 10,5 399.000 and Genetics 2308044 ADAM17/TIMP3 axis modulates immune cell activation in a model of neurovascular dysfunction SANTA LUCIA ORD Brain Disorders and 10,5 400.000 2315821 Prognostic and Predictive microrna Biomarkers in Sarcoma C.R.O. AVIANO ORD Oncology 2 10,5 400.000 Pagina 88 di 332

2308638 HUMANS AND WILDLIFE: ZOOS IN BETWEEN. ARE ZOOS A THREAT OR SENTINELS FOR INFECTIOUS DISEASES? Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary 10,5 410.586 2317295 2311146 2316252 2321516 2309224 2318887 Fast tracking of proximal femur fractures: evaluation of the efficacy by means of quantitative neuromotor conditions assessment at mid time follow up. Long term safety and efficacy of thalidomide in IBD. Validation of an event based progression model of Alzheimer disease incorporating quantitative MRI information Combination of carfilzomib and pomalidomide, two last generation proteasome inhibitor and immunomodulating agents, for the treatment of patients with multiple myeloma relapsed after or refractory to lenalidomide: an international (EMNTG) phase I II clin Innovative therapeutic strategies to prevent microvascular injury, multiple organ failure and mortality in sepsis through inactivation of circulating plasma exosomes: the SEPTOSOMES theory ROLE OF RESIDENT ADULT RENAL PROGENITOR/STEM CELLS IN THE REPAIR OF ACUTE KIDNEY INJURY. A HIGH THROUGHPUT APPROACH BY OMICS AND SYSTEMS LOGY RIZZOLI CLI ORD Surgical, Biomedical Imaging, and Bioengineering 10,5 420.000 BURLO GAROFALO CLI EST Digestive, Kidney 10,5 425.000 and Urological Systems SANTA LUCIA CLI ORD Brain Disorders and 10,5 436.300 CROB ORD Oncology 2 10,5 450.000 Piemonte ORD Immunology 10,5 450.000 Puglia ORD Digestive, Kidney 10,5 450.000 and Urological Systems Pagina 89 di 332

2306728 2320685 Molecular and metabolic signature of Gleason grading in prostate cancer Study on the Mammalian Target of Rapamycin (mtor) signaling pathway as a potential antiepileptogenic therapy Emilia Romagna EST Oncology 1 Basic 10,5 450.000 Calabria ORD Brain Disorders and 10,5 460.000 2312313 Treatment of Neurological Impairment in Lysosomal StorageDiseases by the Use of Neural Stem Cells CASA SOLLIEVO SOFFERENZA ORD Molecular, Cellular, 10,5 461.000 and Developmental 2309909 2318328 Pathogenesis of bone alterations in chronic liver diseases: study and identification of cellular and molecular mechanisms. Determinants of functional recovery in elderly hip fracture subjects admitted to orthogeriatric units: a multicentre observational study. AUXOLOGICO ORD Musculoskeletal, 10,5 462.000 Oral and Skin ARCISPEDALE CLI ORD Healthcare Delivery 10,5 467.500 and Methodologies 2312242 Development of an exosome based in vivo test to detect prions in blood Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Molecular, Cellular, 10,5 480.000 and Developmental 2318228 2320647 2315406 Pathogenetic role and potential clinical exploitation of the CCL2/CCR2 axis in the regulation of immune responses in ALS Chromosomal instability (CIN) and evaluation of new biomarkers for early diagnosis of oral squamous cell carcinoma Striatal synaptic plasticity in experimental models of Parkinson's disease with different degrees of dopamine denervation: molecular mechanisms and therapeutics implications HUMANITAS ORD Immunology 10,5 485.000 Piemonte CLI ORD Oncology 2 10,5 489.500 SANTA LUCIA ORD Brain Disorders and 10,5 490.000 Pagina 90 di 332

2316411 TELE PHYSICO TELEMEDICINE FOR PHYSICAL HEALTH PROMOTION IN TREATED PSYCHIATRIC PATIENTS WITH FUNCTIONAL PSYCHOSES. A multicentre randomised controlled trial. FATEBENEFRATELLI CLI ORD Risk, Prevention 10,5 499.500 and Health Behavior 2318284 Building a Diffusion Tensor Magnetic Resonance Imaging Risk Score to characterize motoneuron disease phenotypes and to discriminate high progressive from low progressive patients with Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis and Progressiv CASA SOLLIEVO SOFFERENZA ORD Bioengineering 10,5 500.000 and Technologies 2318521 2321515 2308054 2314888 2318063 Expression of estrogen receptors and neuroglobin as a new tool to assess stratification of Parkinson's disease patients Modulation of HIF by new synthetic PHD2 inhibitors for a new and effective treatment of ischemic heart failure Study of the P2RX7 gene coding the purinergic P2X7 receptor for extracellular ATP, as a susceptibility marker for Amyotrophic Lateral Sclerosis: genetic and functional analysis of polymorphisms identified in a cohort of ALS patients. PRE CLINICAL EVALUATIONS OF CELL THERAPY FOR OSTEOARTHRITIS TREATMENT Driver mutations and initiating cells in leukaemia: identification of new druggable targets Piemonte ORD Brain Disorders and 10,5 500.000 SAN DONATO EST Cardiovascular and 10,5 500.000 Respiratory SANTA LUCIA ORD Brain Disorders and 10,5 506.000 RIZZOLI EST Musculoskeletal, 10,5 520.000 Oral and Skin I.E.O. ORD Oncology 1 Basic 10,5 535.000 Pagina 91 di 332

2314136 Combining exome sequencing and induced pluripotent stem cells for the identification of novel pathogenetic mechanisms and therapies in human cardiomyopaties MULTIMEDICA ORD Cardiovascular and 10,5 536.596 Respiratory 2302822 IL 21 mediated dysregulation of FoxP3 promotes resistance to tolerance in transplantation SAN RAFFAELE MONTE TABOR ORD Immunology 10,5 540.000 2312237 2311910 2320514 2313222 2315887 2D DIGE based proteomic study for biomarkers discovery in HNPCC patients Localizing the epileptogenic zone in presurgical evaluation of drug resistant focal epilepsies: a complex network based approach A cooperative translational study focused on inflammation and eicosanoids to identify mechanism and predictors of preeclampsia ObeSity And renal Function in pediatric age: an epidemiological study in the CAlabrian region investigating Renal dysfunction in overweight/obese adolescents The SAFEGUARD CKD project. Functionalized polymeric hydrogels and autologous stem cells characterisation as scaffold for tissue regeneration PASCALE ORD Oncology 2 10,5 546.500 CARLO BESTA ORD Surgical, Biomedical Imaging, and Bioengineering 10,5 548.000 Veneto ORD Endocrinology, Metabolism, Nutrition and Reproductive 10,5 550.000 Calabria CLI ORD Population 10,5 550.000 and Epidemiology MULTIMEDICA ORD Bioengineering 10,5 550.000 and Technologies 2321103 Prof of Concept combination strategy for HIV prevention and control: does microbicide during vaccination impact on B cell immune responses? SAN RAFFAELE MONTE TABOR ORD AIDS and Related 10,5 553.960 Research 2321091 Governance of diabetes management in nonspecialistic hospital settings. Emilia Romagna CLI ORD Healthcare Delivery 10,5 555.889 and Methodologies Pagina 92 di 332

2319990 2311255 System biology approach to define etiology and pathogenesis of idiopathic non histaminergic angioedema with normal C1 inhibitor Chronic kidney disease and cardiovascular risk in Italy. A population based longitudinal study exploiting the CNESPS ISS biological specimen bank Lombardia ORD Genes, Genomes and Genetics 10,5 560.000 Istituto Superiore di Sanita' ORD Population 10,5 562.000 and Epidemiology 2320090 Enhanced cell therapy: novel strategies to improve transplanted cell survival and engraftment by protection from oxidative stress OSPEDALE BAMBINO GESU' ORD Vascular and 10,5 570.000 Hematology 2318791 Study of the role of epigenetics in the regulation of microrna expression in heart failure to identify novel therapeutic targets HUMANITAS EST Cardiovascular and 10,5 572.000 Respiratory 2311325 2316981 ROLE OF TGFbeta AND HER 2 PATHWAYS IN THE DEVELOPMENT OF EMT, ENDOCRINE RESISTANCE AND BREAST CANCER PROGRESSION Genetic and antigenic diversity and pathogenicity of viruses associated with enteritis. Sicilia EST Oncology 2 10,5 585.000 Emilia Romagna ORD Infectious Diseases 10,5 599.444 and Microbiology 2320778 In vitro and in vivo effects of post transplant cyclophosphamide as novel immunosuppressive regimen for hematopoietic stem cell transplantation from partially HLA matched donors IRCCS AOU San Martino IST (Genova) ORD Immunology 10,5 600.000 2319224 Neurobiological, pharmacological and clinical studies on Attention Deficit Hyperactivity Disorder (ADHD): from patients to animal models and back. STELLA MARIS ORD Brain Disorders and 10,5 600.000 Pagina 93 di 332

2313247 Antimicrobial Microbubbles (MBs) for treatment of biofilm associated infections. Istituto Superiore di Sanita' ORD Bioengineering 10,5 600.000 and Technologies 2315771 Validation in genetic mouse models and in human cells of two gene therapy approaches against striatal degeneration and Huntington's Disease SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 10,5 600.000 2314384 2316690 2314044 2310415 2319479 2318382 PRECLINICAL DEVELOPMENT OF NOVEL SMALL ANDROGEN RECEPTOR MODULATING MOLECULES (SARMS) IN EXPERIMENTAL HUMAN PROSTATE CANCER MODELS Defining and defeating the negative effects of aging and heart failure on stem cell therapeutic potential alpha7 nachr status and response to donepezil in AD patients GENOTYPE AND ENVIRONMENT INFLUENCES ON THE TUMOR PROLIFERATION DYNAMICS INFERRED WITH NEXT GENERATION SEQUENCING Role of Innate Immunity, Inflammasome and RAAS in the progression of type 2 diabetes through the regulation of hepatic, cardiovascular and endothelial function Assessing human minor histocompatibility antigen (mha) and human Cytomegalovirus (CMV) specific T cell responses as prognostic marker for infection and chronic allograft rejection. Emilia Romagna ORD Oncology 2 10,5 600.000 Friuli Venezia Giulia ORD Cardiovascular and 10,5 600.000 Respiratory SAN RAFFAELE PISANA CLI ORD Brain Disorders and 10,5 600.000 I.E.O. ORD Oncology 1 Basic 10,5 600.000 Lazio ORD Endocrinology, Metabolism, Nutrition and Reproductive 10,5 600.000 Veneto CLI ORD Infectious Diseases 10,75 120.000 and Microbiology Pagina 94 di 332

2310925 FREMS for Acute Inflammatory Bowel Disease: a Phase I/II trial Lazio CLI COF Digestive, Kidney 10,75 150.000 150.000 and Urological Systems 2318511 BRAIN [18F]FDG PET NORMATIVE DATABASE Toscana CLI ORD Brain Disorders and 10,75 165.000 2298984 2321867 Serine racemase: an emerging therapeutic target for the treatment of schizophrenia and neurodegenerative diseases. EVALUATION OF THE ROLE OF HPV INDUCED IMMUNE RESPONSE IN VACCINE RELATED EFFICACY: COMPARISON BETWEEN BIVALENT AND QUADRIVALENT HPV VACCINES IN FEMALES AND MALES MAUGERI ORD Biological Chemistry and Macromolecular Biophysics 10,75 280.000 MAGGIORE ORD Risk, Prevention 10,75 350.000 and Health Behavior 2314560 Staphylococcal enterotoxin in traditional raw ewe milk Pecorino cheese: risk assessment and proteomic characterization Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary 10,75 360.000 2312563 2310964 EXPERIMENTAL EVIDENCES ON POSSIBLE TOXIC EFFECTS OF LEVODOPA ON MAMMALIAN SUBSTANTIA NIGRA DOPAMINERGIC NEURONS A toxicological redox assay as a new tool for the discovery of susceptibility biomarkers in Parkinson s disease SANTA LUCIA ORD Brain Disorders and 10,75 396.000 MONDINO EST Brain Disorders and 10,75 492.800 2307511 Experimental intra tonsillar prion infection in sheep: a pathogenetic insight into classical and atypical scrapie propagation. Istituto Zooprofilattico Sperimentale della Sardegna ORD Veterinary 11 25.000 2310911 Common pathogenic pathways in Motor Neuron Diseases : a study on the relation between SMN and TLS/FUS SANTA LUCIA ORD Molecular, Cellular, 11 150.000 and Developmental Pagina 95 di 332

2314968 2313378 2320690 2309401 2318729 Genetic polymorphisms and noninvasive scores for screening patients with progressive nonalcoholic fatty liver disease (NAFLD): an international multicenter collaborative study Early integration of palliative care with standard oncologic care in advanced non small cell lung cancer. A prospective, multi center observational study to evaluate how this approach impact on patient s survival and quality of life with an additional ana HBV related chronic hepatitis: bone metabolism study in naïve patients and in long term therapy with nucleos(t)ide analogue Efficacy of chronomodulated opioid administration in the prevention of breakthrough cancer pain: a phase III randomized multicentre trial Hydrocarbons and kidney damage: potential use of Neutrophil Gelatinase associated Lypocalin and Sister Chromatide Exchange Piemonte ORD Digestive, Kidney 11 150.000 and Urological Systems I. O. V. CLI ORD Healthcare Delivery 11 150.000 and Methodologies Piemonte CLI ORD Digestive, Kidney 11 150.000 and Urological Systems Piemonte CLI ORD Oncology 2 11 150.000 Istituto Superiore di Sanita' CLI ORD Digestive, Kidney 11 150.000 and Urological Systems 2305813 Evaluation of Opisthorchis felineus metacercariae infectivity after fish fillets freezing at different time temperature combinations. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana ORD Veterinary 11 150.600 2310616 2313565 Biological nurturing and exclusive breastfeeding at 12 weeks: a randomised controlled trial Estimation of cured patients among persons living with neoplasms BURLO GAROFALO CLI ORD Healthcare Delivery 11 152.786 and Methodologies C.R.O. AVIANO ORD Population 11 161.000 and Epidemiology Pagina 96 di 332

2316064 IDENTIFYING CORRELATIONS BETWEEN GENOTYPES AND PHENOTYPES OF DENT'S DISEASE. PARTICIPATION TO THE INTERNATIONAL DENT S DISEASE REGISTRY Veneto ORD Digestive, Kidney 11 182.900 and Urological Systems 2314000 Inflammasome deregulation in the macrophage lineage in the pathogenesis of CRMO OSPEDALE BAMBINO GESU' ORD Musculoskeletal, 11 190.000 Oral and Skin 2309826 2321854 2317426 ROLE OF MITOCHONDRIAL OXIDATIVE METABOLISM AND REDOX SIGNALING IN ADULT STEM CELL PROLIFERATION AND DIFFERENTIATION: DEVELOPMENT OF INNOVATIVE STRATEGIES FOR EX VIVO HEMATOPOIETIC STEM CELL EXPANSION TO BE USED IN ONCO HEMATOLOGICAL THERAPIES Dissecting microrna function in mesothelioma development and progression Role of Echocardiogram combined with biomarkers and mirna in early detection of myocardial injury do to anthracyclines and trastuzumab. CROB ORD Vascular and Hematology 11 200.000 PASCALE ORD Oncology 1 Basic 11 200.000 Emilia Romagna ORD Cardiovascular and 11 209.000 Respiratory 2311188 Correlation between HIV Associated Neurocognitive Disorders (HAND) and HIV and Cytomegalovirus (CMV) specific immune activation and inflammation in peripheral blood and central nervous system (CNS) in HIV infected antiretroviral naive patients Lombardia CLI ORD AIDS and Related 11 210.000 Research 2311399 PREVENTION AND DIAGNOSIS OF FETAL ALCOHOL SYNDROME (FAS) AND FETAL ALCOHOL SPECTRUM DISORDER (FASD) AMONG ITALIAN REGIONS Lazio CLI ORD Risk, Prevention 11 240.250 and Health Behavior Pagina 97 di 332

2314973 2315765 2321880 2316947 Nanoparticle delivered gene therapy to overcome remyelination failure resulting from blocked mature oligodendrocytes in multiple sclerosis like disease Targeting Th17 in cystic fibrosis as a pharmacological strategy and immunogenetic screening A novel approach for fusion transcript identification and its application to primary malignant bone tumours. Study of basic and clinical aspects of mitotane treatment in patients with adrenocortical carcinoma. CARLO BESTA ORD Brain Disorders and 11 240.700 Umbria ORD Infectious Diseases 11 241.994 and Microbiology Toscana ORD Genes, Genomes 11 243.000 and Genetics Piemonte ORD Oncology 2 11 250.000 2308082 LOGICAL APPROACH TO DECONTAMINATION OF BIVALVE MOLLUSCS FROM V.PARAHAEMOLYTICUS AND SALMONELLA BY MARINE BDELLOVIBRIO AND LIKE ORGANISMS (BALOs) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary 11 250.000 2314513 ABCB1/P glycoprotein expression: a biological stratification of the risk in patients with non metastatic osteosarcoma of the extremity. An Italian Sarcoma Group prospective study (ISG/OS 2). Emilia Romagna CLI ORD Oncology 2 11 250.000 2312066 2322049 Efficacy of a neuromotor and cognitive behavioural training for disability, kinesiophobia and gait disturbances in chronic non specific low back pain An Italian multidisciplinary clinic for Wolfram Syndrome MAUGERI CLI ORD Musculoskeletal, 11 251.000 Oral and Skin GASLINI CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 11 251.472 Pagina 98 di 332

2319902 2309665 2318964 2312893 2320894 gene environment and gene gene association analyses on cognitive phenotypes in Italian nuclear families of dyslexia A novel in vivo diagnostic test for Creutzfeldt Jakob disease (CJD) patients by nasal brushing Modeling Leigh Syndrome with induced pluripotent stem cells: novel tools to investigate energetic neuronal metabolism. The role of the cerebellum in emotion recognition processes: cerebellar TMS as a rehabilitative treatment for schizophrenic patients. Glioblastoma multiforme long survivors: impact of molecular profile on prognosis MEDEA ORD Brain Disorders and 11 254.000 Istituto Superiore di Sanita' EST Brain Disorders and 11 270.000 MAGGIORE ORD Brain Disorders and 11 285.000 SANTA LUCIA CLI ORD Brain Disorders and 11 290.500 Toscana ORD Oncology 2 11 291.000 2317971 Does timing of VT ablation affect prognosis in patients with an implantable cardioverterdefibrillator? SAN RAFFAELE MONTE TABOR CLI ORD Cardiovascular and 11 295.000 Respiratory 2304412 2316163 Unraveling the molecular basis of neurodegeneration in frontotemporal lobar degeneration : role of genome instability associated with tau mutations Diagnostic impact of circulating mirna and cancer cells in poorly differentiated carcinomas of the lung and breast. CARLO BESTA ORD Brain Disorders and 11 299.950 Emilia Romagna ORD Oncology 2 11 300.000 2321184 TDP43 translocation in response to synaptic SANTA LUCIA ORD Molecular, Cellular, 11 300.000 activation: a study on wild type and mutant forms. and Developmental Pagina 99 di 332

2312185 Pancreatic non endocrine fraction conversion into insulin producing tissue by acting on TLRs: a potential pathway to improve the transplantable beta cell mass for T1DM therapy SAN RAFFAELE MONTE TABOR ORD Endocrinology, Metabolism, Nutrition and Reproductive 11 300.000 2307118 Molecular genetic variants and circulating levels of natriuretic peptides: assessment of their predictive role for cardiovascular acute events and cardiovascular diseases in a general Italian population NEUROMED CLI EST Cardiovascular and 11 300.000 Respiratory 2309134 New insigths in the treatment of necrotizing enterocolitis: Modulation of the cholinergic antiinflammatory Sicilia EST Surgical, Biomedical 11 300.000 pathway with the use of Imaging, and Bioengineering melanocortins in an experimental neonatal model. 2316849 INVESTIGATING PROGRESSION FROM SAN RAFFAELE MONTE PRENEOPLASTIC TO NEOPLASTIC DISEASE IN TABOR ESOPHAGEAL AND PANCREATIC CANCER BY MEANS OF AN INTEGRATIVE GENOMICS NEXT GENERATION SEQUENCING BASED APPROACH. CLI ORD Digestive, Kidney 11 300.000 and Urological Systems 2316131 2318650 Alliance for secondary cardiovascular prevention in the Emilia Romagna region: a randomised clinical trial comparing an intensive, nurse led structured programme with usual care Group I metabotropic glutamate receptors and regulation of synaptic plasticity in a mouse model of Angelman syndrome Emilia Romagna CLI ORD Cardiovascular and 11 300.000 Respiratory NEUROMED EST Brain Disorders and 11 300.000 2307445 2311056 Exploiting the p53 p66shc signalling pathway to identify new molecular markers for the prevention of cancer and age related diseases I.E.O. ORD Biology of 11 305.000 Development and Aging The role of mirna in MYC regulatory network Toscana ORD Oncology 1 Basic 11 308.000 Pagina 100 di 332

2316730 Interplay between cancer senescent cells and immune system: implications for treatment of breast cancer MAUGERI ORD Oncology 1 Basic 11 320.000 2318967 Toremifene in desmoid tumors: safety, efficacy and potential therapeutic targets. ISTITUTO TUMORI MILANO CLI ORD Oncology 2 11 330.120 2316915 Structure/function relationships of the long pentraxin PTX3 in the light of its protective role in invasive aspergillosis HUMANITAS ORD Immunology 11 337.000 2314341 Identification of novel biomolecular targets of pets spontaneous carcinomas for the development of new diagnostic and therapeutics approaches: use of the human knowledge to accelerate the management of pets tumors. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana ORD Veterinary 11 350.000 2311904 2310854 2308550 Astrocytic impact to corticostriatal synaptic processing in a mouse model of DYT1 Dystonia Role of the ghrelin gene derived peptides and growth hormone releasing hormone (GHRH) on microrna expression and function in the heart ADVANCED THERAPY IN THE TREATMENT OF SKIN LOSS: HUMAN ALLODERMIS WITH PLATELET GEL AND MINIMALLY MANIPULATED MESENCHIMAL STEM CELLS. SANTA LUCIA ORD Molecular, Cellular, 11 370.000 and Developmental Piemonte ORD Cardiovascular and 11 371.000 Respiratory Toscana CLI EST Surgical, Biomedical Imaging, and Bioengineering 11 372.000 2302604 Role of IL 4 producing granulocytes in thymic stromal lymphopoietin dependent Th2 type inflammation in pancreatic cancer SAN RAFFAELE MONTE TABOR ORD Immunology 11 375.000 2320967 The early phases of diabetic retinopathy: possible role of Pigmented Epithelium Derived Factor in contrasting neuroglial dysfunction Istituto Superiore di Sanita' EST Cell Biology 11 380.000 Pagina 101 di 332

2316391 Functional role of macrophage migration inhibitor factor (MIF) and D dopachrome tautomerase (D DT) in thyroid and colorectal cancer ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 11 385.000 2315335 2319427 2304785 2312057 2312282 2317132 2316609 Genomic and proteomic profiling in Traumatic Brain Injury patients. Drug drug interactions with antidepressants: identification, impact and prevention in clinical practice Correction of Beta Haemoglobinopathies after in situ gene transfer by homologous recombination GENETIC DETERMINANTS OF LEFT VENTRICULAR HYPERTROPHY Disentangling prenatal and postnatal influences on infant bio behavioral development: a prospective study. Effect of lower limb end effector robot assisted therapy with body weight support vs treadmill gait training in Parkinson Patients. Prediction of preeclampsia:a proteomic approach for identification of novel biomarkers Sicilia EST Brain Disorders and 11 397.000 NEUROLESI CLI ORD Population 11 400.000 and Epidemiology Liguria EST Genes, Genomes 11 400.000 and Genetics AUXOLOGICO ORD Cardiovascular and 11 401.000 Respiratory MEDEA ORD Biobehavioral and 11 401.300 Behavioral Processes SAN RAFFAELE PISANA CLI ORD Brain Disorders and 11 410.000 Istituto Superiore di Sanita' ORD Endocrinology, Metabolism, Nutrition and Reproductive 11 411.000 2313253 Detection of pathological prion protein in cerebrospinal fluid by real time quaking induced conversion (QuIC): Evaluation and standardization of a novel disease specific laboratory test for the diagnosis of sporadic Creutzfeldt Jakob disease. Istituto Scienze Neurologiche ORD Brain Disorders and 11 420.200 Pagina 102 di 332

2317038 DEVELOPMENT OF A FULL WIRELESS POLYGRAPHIC DEVICE FOR DIAGNOSIS OF SLEEP DISORDERS AND REMOTELY ATTENDED HOME MONITORING AUXOLOGICO CLI ORD Emerging Technologies and Training in s 11 425.500 2310897 Immunesurveillance of leukemia by CD1 restricted T cells specific for self lipid antigens SAN RAFFAELE MONTE TABOR ORD Immunology 11 430.000 2312395 2317573 2315465 2316804 2321640 2318041 2319243 FROM SANGER TO NEXT GENERATION SEQUENCING IN MOLECULAR MEDICINE Quantitative evaluation of the function of the elbow operated through inertial devices PET, serum tumour markers and circulating tumour cells in treatment efficacy assessment for patients with advanced non small cell lung cancer (NSCLC) Whole Exome sequencing a novel modality for diagnostics and disease gene discovery in Cardiomyopathies Gold nanoparticles targeting of beta amyloid plaques in the brain of animal models of Alzheimer's disease Enteric glial cells: at the crossroads of obesity, gastrointestinal neurodysfunction and gut bacterial endotoxins Collaboratory and remote mentoring: a strategy to optimize pancreatic islet isolation. SAN MATTEO CLI ORD Genes, Genomes 11 434.000 and Genetics RIZZOLI ORD Musculoskeletal, 11 441.600 Oral and Skin Emilia Romagna CLI ORD Oncology 2 11 450.000 MULTIMEDICA CLI ORD Genes, Genomes 11 455.550 and Genetics Toscana ORD Brain Disorders and 11 460.000 MEDEA EST Digestive, Kidney 11 460.000 and Urological Systems Sicilia EST Endocrinology, Metabolism, Nutrition and Reproductive 11 462.000 Pagina 103 di 332

2321467 2313461 Circulating micrornas as cancer specific biomarkers Green biofactories and biomolecules for the production of safe, low cost and improved anticancer HPV vaccines. Emilia Romagna ORD Oncology 2 11 463.500 REGINA ELENA ORD Oncology 2 11 475.000 2317172 Person/Patient and Family centred care PCC & FCCUnderstanding health care experiences and perceptions of parents of hospitalized premature infants, children with a chronic condition and their parents and health professionals in South Tyrol and other reg Provincia autonoma Bolzano CLI ORD Healthcare Delivery 11 477.475 and Methodologies 2308444 2300483 2311472 2314609 2311059 REFINING THE CLINICAL HETEROGENEITY OF AUTISM: WHOLE EXOME SEQUENCING OF MACROCEPHALIC AUTISTIC PATIENTS Assessment and management of cardiovascular risk in perimenopausal women undergoing breast cancer screening Deep brain stimulation of the reticular nucleus of the thalamus as a therapy for intractable epilepsy: preliminary investigation. New Amyloid beta oligomeric assemblies in Alzheimer derived samples and their subcellular targeting in living human primary fibroblasts MESOANGIOBLASTS FOR THE CELL THERAPY OF FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY (FSHD): EXPLORING SKELETAL MUSCLE DIFFERENTIATION OF FSHD MESOANGIOBLASTS IN VITRO AND IN VIVO IN SCID MICE AND IN A MOUSE MODEL OF FSHD. SANTA LUCIA ORD Genes, Genomes 11 480.000 and Genetics AUXOLOGICO CLI ORD Healthcare Delivery 11 480.000 and Methodologies Toscana ORD Brain Disorders and 11 495.000 FATEBENEFRATELLI ORD Brain Disorders and 11 498.000 DON GNOCCHI ORD Musculoskeletal, 11 500.000 Oral and Skin Pagina 104 di 332

2313141 Treatment optimization of recurrent glioblastoma Emilia Romagna CLI ORD Oncology 2 11 500.000 2321629 Fragile X Protein in breast cancer progression CASA SOLLIEVO SOFFERENZA EST Oncology 1 Basic 11 500.000 2306427 2318948 2312601 DEVELOPMENT OF MICRORNA BASED ASSAYS FOR DIAGNOSTIC AND THERAPEUTIC INTERVENTION IN STROKE Characterization of anal HPV infection and associated lesions in immunocompetent and immunocompromised hosts. RELATIONSHIP BETWEEN SIRTUIN AND UNCOUPLING PROTEIN GENES AND VASCULAR AGING SDN ORD Brain Disorders and 11 512.000 SAN GALLICANO ORD Oncology 1 Basic 11 518.900 SAN RAFFAELE PISANA ORD Genes, Genomes 11 520.000 and Genetics 2307246 Sp140 PHD finger as a potential target for chronic lymphocytic leukemia: a multidisciplinary approach SAN RAFFAELE MONTE TABOR ORD Biological Chemistry and Macromolecular Biophysics 11 550.000 2317851 2309252 2316248 2307049 Unveiling the microbial signature of Coeliac Disease MicroRNA as predictive biomarkers in Hepatoblastoma pediatric tumour Predictive markers of the response to acetylcholinesterase inhibitors in Alzheimer s disease Perinatal stress in human and non human offspring: a translational approach to study epigenetic impact on depression. SDN EST Infectious Diseases 11 550.000 and Microbiology Istituto Superiore di Sanita' EST Oncology 1 Basic 11 550.000 Lombardia ORD Brain Disorders and 11 554.000 Istituto Superiore di Sanita' ORD Biobehavioral and 11 560.000 Behavioral Processes Pagina 105 di 332

2308023 Standardized Brain Imaging Database for the Evaluation of Memory Disorders and Cognitive Reserve in Mild Cognitive Impairment and Alzheimer's Disease (SBIDMDCR) SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 11 560.000 2312132 2318297 2317370 2310171 Development of novel drugs targeting protozoan agents of tropical diseases imported in Italy Exploring the role of Epstein Barr virus infection and innate immune signalling pathways in the pathogenesis of myasthenia gravis Allergens, chemical and biological contaminants in nursery and primary schools: a proposal of a multi method approach for the assessment of the main risk pollutants ANTI INFLAMMATORY ACTIVITY OF POLYPHENOLS IN CANCERCHEMOPREVENTION: IN VITRO AND IN VIVO STUDIES Istituto Superiore di Sanita' ORD Infectious Diseases 11 563.310 and Microbiology CARLO BESTA EST Brain Disorders and 11 567.248 Istituto Superiore di Sanita' ORD Risk, Prevention 11 570.000 and Health Behavior Istituto Superiore di Sanita' ORD Endocrinology, Metabolism, Nutrition and Reproductive 11 576.000 2319138 Safe eradication of chemoresistant myeloid leukemia with CD44v6 redirected T cells coexpressing a suicide gene SAN RAFFAELE MONTE TABOR ORD Oncology 2 11 577.500 2307307 2314014 Safety and efficacy of infusion of human adiposederived mesenchymal cells in experimental models of whole and partial liver transplantation in large size animals. DISCHARGE FROM FORENSIC MENTAL HOSPITALS, COMMUNITY TENURE, AND RISK OF RECIDIVISM: A PROSPECTIVE FOLLOW UP STUDY Emilia Romagna ORD Digestive, Kidney 11 579.425 and Urological Systems Lombardia CLI ORD Healthcare Delivery 11 580.000 and Methodologies Pagina 106 di 332

2318405 Significance of Sentinel Node Micrometastasis in Breast Cancer Progression C.R.O. AVIANO CLI ORD Oncology 2 11 583.000 2315633 DISCO TRIP: Disrupting mitochondrial complex I to trigger pseudonormoxia: an anticancer strategy. Emilia Romagna ORD Oncology 1 Basic 11 586.264 2318863 2318206 DEVELOPMENT OF A THYROID CANCER DATABASE TO IMPROVE THE QUALITY OF CLINICAL PRACTICE AND REDUCE PUBLIC HEALTH COSTS Testing in a whole community the effectiveness of an intensive and comprehensive drug abuse preventive program through wastewater analysis, a novel approach for sensitive and real time estimation of drug consumption Lazio CLI ORD Oncology 2 11 590.000 Lombardia CLI ORD Risk, Prevention 11 590.000 and Health Behavior 2318911 CLINICAL AND GENETIC CHARACTERIZATION OF EARLY COMPLICATIONS IN JUVENILE OBESITY OSPEDALE BAMBINO GESU' CLI EST Endocrinology, Metabolism, Nutrition and Reproductive 11 592.000 2299665 2311016 Novel therapeutic approaches to counteract neuronal loss and cognitive decline in an animal model of AD Hexanucleotide repeat expansion in c9orf72 as a bridge between amyotrophic lateral sclerosis and other neurodegenerative diseases. Abruzzo EST Brain Disorders and 11 592.072 AUXOLOGICO EST Brain Disorders and 11 593.000 2308349 Exploiting the therapeutic and prognostic potential of micrornas in melanoma ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Oncology 2 11 594.000 Pagina 107 di 332

2305885 GENOMIC VARIATION AND PROTEOMIC PROFILE IN NEONATAL BRONCOPULMONARY DYSPLASIA AND RESPIRATORY DISTRESS CLINICAL SPECTRUM SAN RAFFAELE MONTE TABOR ORD Genes, Genomes 11 594.000 and Genetics 2319219 2308935 2315619 Control of genome organization by regenerationactivated p38alpha signalling in muscle stem cells Multicenter,Italian,randomized,openlabel,parallel group, non inferiority phase III clinical trial comparing cisplatin 5Fluorouracilcetuximab vs. carboplatin paclitaxel cetuximab in recurrent/metastatic squamous cell carcinoma of the head and neck New potential targets for reverting diabetic dysfunction in progenitor cells mobilization and homing SANTA LUCIA ORD Biology of 11 595.000 Development and Aging Lombardia CLI ORD Oncology 2 11 598.000 MULTIMEDICA ORD Cardiovascular and 11 599.370 Respiratory 2315590 Investigating fetal programming of complex diseases: role of periconceptional and pregnancy nutrient intake on neonate epigenome and health. SAN RAFFAELE MONTE TABOR ORD Genes, Genomes 11 600.000 and Genetics 2314345 VALIDATION OF NANOPARTICLES FOR DRUG DELIVERY IN HEREDITARY NEUROMUSCULAR DISEASES TREATMENTS OSPEDALE BAMBINO GESU' ORD Molecular, Cellular, 11 600.000 and Developmental 2321650 New therapeutic strategies for the control of fungal infections in the elderly Istituto Superiore di Sanita' ORD Infectious Diseases 11 600.000 and Microbiology 2318158 Application of molecular techniques to identify zoonosis agents transmitted by arthropods. Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 11 600.000 2312631 Low dose effects: in vivo models of chemotherapyradiation therapy interactions Emilia Romagna ORD Oncology 2 11 600.000 Pagina 108 di 332

2312103 TRAIN: Training through Research Application Italian initiative Istituto Superiore di Sanita' ORD Interdisciplinary 11 600.000 Molecular and Training 2319431 Chimeric antigen receptor redirected T cells targeting CD19 for therapy of high risk/relapsed childhood acute lymphoblastic leukemia OSPEDALE BAMBINO GESU' EST Oncology 2 11 600.000 2318356 Role of acetylcholinesterase R in the treatment of Myastenia Gravis. SAN RAFFAELE PISANA CLI ORD Oncology 2 11 600.000 2315795 Genetics of cardiovascular disease in patients with type 2 diabetes. An integrated approach, including epidemiology, gene expression profiles and cell biology functional studies CASA SOLLIEVO SOFFERENZA EST Genes, Genomes 11 600.000 and Genetics 2321145 2316435 2320441 Multimodal evaluation of stroke patient's mindbrain state during upper limb robot aided therapy Sebum lipidomics: a new tool to correlate skin and systemic lipid metabolism. Integrated approach to the small fetus: how different patterns of fetal growth impact on neonatal morbidity and long term auxological, neurodevelopmental and metabolic outcomes SAN RAFFAELE PISANA CLI ORD Emerging Technologies and Training in s 11 600.000 SAN GALLICANO COF Musculoskeletal, 11 600.000 414.000 Oral and Skin Piemonte CLI ORD Risk, Prevention 11 600.000 and Health Behavior 2313227 Amantadine treatment for pathological gambling FATEBENEFRATELLI CLI ORD Brain Disorders and 11 600.000 2308914 Hypothesis driven gene candidate study of copper involvement in the pathogenesis of Alzheimer s disease: detection of sequence changes, haplotype profile of ATP7B gene and their molecular and functional aspects SAN RAFFAELE PISANA CLI ORD Brain Disorders and 11 600.000 Pagina 109 di 332

2321426 2311620 New paradigms for Tuberculosis (TB) management using rapid molecular detection of Mycobacterium tuberculosis and Rifampin resistance DO INHIBITORY NETWORKS SUSTAIN SEIZURE GENESIS IN FOCAL EPILEPSY? Emilia Romagna CLI ORD Infectious Diseases 11 2.275.000 and Microbiology CARLO BESTA EST Brain Disorders and 11,25 300.500 2311517 Proteomic signatures as biomarkers of breast cancer risk andas predictors of outcome in women with early breast cancer. IRCCS AOU San Martino IST (Genova) ORD Oncology 2 11,25 350.000 2303620 2306977 2309041 2305373 2316285 2307180 SENESCENCE ASSOCIATED micrornas (SAmiRs) IN CELLULAR SENESCENCE AND ORGANISMAL AGING Liposome delivered sirnas inhibition of PTG in Lafora Disease: a model of innovative strategy for treatment of neurometabolic diseases Boosting intratumor tertiary lymphoid structures with IL 7 and LT alpha, to stimulate the immune response against pancreatic cancer. SCREENING OF SOMATIC MUTATIONS IN ADVANCED STAGES LUNG ADENOCARCINOMA THROUGH NEXT GENERATION DNA SEQUENCING Mobile genetic elements: new approaches to molecular epidemiology of antimicrobial resistance genes in Gram negative clinical isolates A Pharmacogenomic Approach to Retinal Neuroprotection in Age Related Macular Degeneration. SDN ORD Biology of 11,25 400.000 Development and Aging GASLINI ORD Genes, Genomes 11,25 450.000 and Genetics HUMANITAS ORD Immunology 11,25 470.250 I.E.O. ORD Oncology 1 Basic 11,25 499.756 Abruzzo ORD Infectious Diseases 11,34 300.000 and Microbiology Lazio CLI ORD Cell Biology 11,5 78.500 Pagina 110 di 332

2316263 2321347 2315093 2317265 An epigenetic approach to treatment of triple negative breast cancer Identification of chromosomal mosaicisms in amniotic fluid of pregnant women by Pyrosequencing analysis. Therapeutic drug monitoring protocols for dose personalization of antibacterial agents administered to patients with severe Grampositive infections Fertility preservation in women affected by endometriosis through oocyte vitrification Friuli Venezia Giulia ORD Oncology 1 Basic 11,5 120.000 MAGGIORE ORD Genes, Genomes 11,5 134.000 and Genetics Toscana CLI ORD Healthcare Delivery 11,5 135.000 and Methodologies Toscana CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 11,5 150.000 2319366 2313933 PHASE 2, OPEN LABEL, MULTICENTER, RANDOMIZED STUDY OF PD 0332991 (ORAL CDK 4/6 INHIBITOR) MONOTHERAPY AND PD 0332991 IN COMBINATION WITH THE AROMATASE INHIBITOR TO WHICH THE PATIENT HAS PROGRESSED IN THE PREVIOUS LINE FOR ER POSITIVE, HER2 NEGATIVE POST M Toscana CLI ORD Oncology 2 11,5 150.000 PRESERVATION OF THE REPRODUCTIVE FUNCTION IN ONCOLOGICAL CHILDREN AND WOMEN AT RISK OF STERILITY: OVARIAN TISSUE CRYOPRESERVATION IN HYPERBARIC CONDITIONS Emilia Romagna ORD Endocrinology, Metabolism, Nutrition and Reproductive 11,5 160.000 2317044 LOW INVASIVE MARKERS DEVELOPMENT IN COLLAGEN 6 MYOPATHIES AND DUCHENNE MUSCULAR DYSTROPHY FOR DISEASE STAGING AND RESPONSE TO TREATMENT RIZZOLI CLI ORD Musculoskeletal, 11,5 165.000 Oral and Skin Pagina 111 di 332

2321798 Citicoline treatment for traumatic brain injury NEUROLESI CLI ORD Brain Disorders and 11,5 168.500 2320841 2321251 2313839 Development of a health surveillance system to monitor the impact of rheumatoid arthritis, the quality of care and long term consequences of the disease at the population level Health and equity effects of natural policy experiments in the fields of structural policies and health care organization Acid Retinoic Producing Dendritic Cells as New Therapy for Type 1 Diabetes SAN MATTEO CLI ORD Population 11,5 176.000 and Epidemiology Piemonte CLI ORD Healthcare Delivery 11,5 180.000 and Methodologies Sicilia EST Immunology 11,5 180.000 2320042 Targeting patients with recurrent depression and traumas: Comparison of the efficacy of EMDR and of CBT versus standard clinical management, their neurobiological correlates, and the associated health sanitary costs. Piemonte CLI ORD Biobehavioral and 11,5 189.000 Behavioral Processes 2307181 2316204 Perception deficits and visual agnosia in very low birth weight (VLBW) children EFFECTS OF NUTRACEUTICAL SPIRULINA AND DOCOSAHEXAENOIC ACID ENRICHED DIET DURING PREGNANCY AND LACTATION ON NEURODEVELOPMENT AND SUSCEPTIBILITY TO INFLAMMATION OF THE PROGENY STELLA MARIS CLI ORD Brain Disorders and 11,5 190.000 Istituto Superiore di Sanita' ORD Molecular, Cellular, 11,5 192.000 and Developmental 2320736 In vivo manipulation of gamma delta T cells with zoledronate and low dose IL 2 for immunotherapy of malignant melanoma Sicilia CLI ORD Oncology 2 11,5 193.750 2309891 INHIBITION OF GLYCOGEN SYNTHASE KINASE 3 TO IMPROVE THE INTEGRATION OF ENDOSSEOUS IMPLANTS Emilia Romagna ORD Musculoskeletal, 11,5 200.000 Oral and Skin Pagina 112 di 332

2310483 2316608 Individual Susceptibility to Plaque Induced Periodontal Inflammation: Evaluation of Genetic,, Immunological and Microbiological Markers. Management of couples with asymptomatic urogenital infections and ART failure Emilia Romagna ORD Musculoskeletal, 11,5 200.000 Oral and Skin Toscana CLI ORD Infectious Diseases 11,5 200.000 and Microbiology 2318256 Posttraumatic stress disorder in parents of children with surgically correctable anomalies requiring surgery at birth OSPEDALE BAMBINO GESU' CLI ORD Biobehavioral and 11,5 200.000 Behavioral Processes 2314718 A new system for integrating monitoring of cardiovascular and neuromuscular activity during free living: set up and clinical validation in patients affected by cardiac arrhythmias and neurological disorders Toscana ORD Cardiovascular and 11,5 202.500 Respiratory 2317653 value of decompressive craniectomy associated to haematoma evacuation in the first 72 hours after traumatic events: a multicenter randomized controlled trial Emilia Romagna CLI ORD Surgical, Biomedical Imaging, and Bioengineering 11,5 208.888 2304124 Caveolin 1, PTRF expression and function in Non Small Cell Lung Cancer. IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 11,5 215.000 2318935 2316798 2319723 Diagnosis of estrogen receptor positive breast cancers: innovative markers of risk categories DNA REPAIR SYSTEM AND CISPLATIN RESISTANCE IN OSTEOGENIC BONE TUMOURS: VALIDATION OF MOLECULAR TARGETS AND CLINICAL APPLICATIONS and Molecular aspects of Sunitinib related hyperlipidemia. Piemonte CLI ORD Oncology 1 Basic 11,5 220.000 RIZZOLI ORD Oncology 2 11,5 225.500 Toscana ORD Oncology 2 11,5 225.500 Pagina 113 di 332

2320881 2321811 2317817 2316818 2302996 2318794 2311132 2317279 2310842 Proteomics and metabonomics strategies to characterize functional biomarkers of Polycyclic aromatic hydrocarbons contamination on dairy products Molecular analysis of Streptococcus pneumoniae and Neisseria meningitidis serotypes/serogroups and potential coverage of available vaccines Development and characterization of a motoneuronal in vitro model of spinal muscular atrophy: a novel platform for the evaluation of candidate compounds to the treatment of the condition Electronic Medical Record for PDD: A powerful tool for health care, clinical governance and epidemiological studies Epigenetic therapy of leukemic stem cells in acute myeloid leukemias. and healthcare strategies for improving quality of life in persons affected by spinal cord injuries: Tuscany regional network and use of innovative technological devices Viral respiratory infections in intensive care patients. Role of CREB protein family members in human lymphoid malignancies Nutlin 3 as innovative diagnostic and therapeutic tool for B chronic lymphocytic leukemia Abruzzo ORD Veterinary 11,5 230.000 Toscana ORD Immunology 11,5 240.000 Lazio ORD Molecular, Cellular, 11,5 250.000 and Developmental Istituto Superiore di Sanita' ORD Healthcare Delivery 11,5 252.000 and Methodologies I.E.O. ORD Oncology 1 Basic 11,5 254.000 Toscana CLI ORD Musculoskeletal, 11,5 258.800 Oral and Skin Toscana ORD Infectious Diseases 11,5 260.000 and Microbiology Abruzzo ORD Cell Biology 11,5 274.369 BURLO GAROFALO CLI ORD Oncology 2 11,5 280.000 Pagina 114 di 332

2316205 2319313 2321716 2319525 2316786 2307775 2299313 2320054 BPIFB4 longevity associated variants: evaluation by in vitro and in vivo studies for their potential modulation of diseases of aging Set up and clinical validation of an immunometric assay for the quantification of big gammaglutamyltransferase (b GGT), an emerging biomarker of cardiovascular risk. MITO 7 A Multicenter phase 3 Randomized Study with weekly paclitaxel in patients with Ovarian Cancer treated with first line chemotherapy GENE EXPRESSION PROFILING IN HUMAN ACTH SECRETING PITUITARY TUMORS IN ASSOCIATION WITH CLINICAL AND CHEMICAL FEATURES. Vitamin D as a disease modulator in multiple sclerosis: immunomodulatory activity on antigen presenting cells and gamma/delta T lymphocytes and regulation of their cross talk. Novel predictive biomarkers for bevacizumab in colorectal cancer Neurophysiological approach to evaluate cerebrocerebellar interactions. Characterization of a cerebellar connectivity EEG index. Disability related chronic conditions in older adults: an innovative approach to estimate the disease burden and the adherence to evidencebased pharmacological treatments using linked clinical and administrative data. MULTIMEDICA ORD Biology of 11,5 286.400 Development and Aging Toscana ORD Cardiovascular and 11,5 290.000 Respiratory PASCALE CLI ORD Oncology 2 11,5 293.550 AUXOLOGICO ORD Endocrinology, Metabolism, Nutrition and Reproductive 11,5 300.000 Istituto Superiore di Sanita' ORD Immunology 11,5 300.000 I. O. V. ORD Oncology 2 11,5 300.000 SANTA LUCIA CLI ORD Brain Disorders and 11,5 300.000 Lazio CLI EST Healthcare Delivery 11,5 300.000 and Methodologies Pagina 115 di 332

2308014 2311018 Cutaneous sensory and autonomic innervation in early parkinsonism. A new tool to predict clinical evolution toward PD, MSA and PSP. Identification of humoral and cellular biomarkers for cerebro and coronary acute vascular events MAUGERI CLI ORD Brain Disorders and 11,5 300.000 NEUROMED CLI EST Vascular and 11,5 300.000 Hematology 2317809 Evaluation of the role of Copy Number Variations in the pathogenesis of inherited neurological and neuromuscular disorders through the development and validation of a rapid and efficient laboratory assay IRCCS AOU San Martino IST (Genova) ORD Genes, Genomes 11,5 325.000 and Genetics 2311169 2302679 2312572 2317577 2320359 2315319 2313798 Autoimmunity in Diabetes: a Holistic Hypothesis of the Diabetes Syndrome Targeting epithelial to mesenchymal transition and chemoresistance mediated by endothelin 1 signaling in epithelial ovarian cancer Reproductive toxicity of Engineered Nanomaterials: mechanisms, effects, biomonitoring and tools for prevention Thyroid hormones, brain tumours and macrophages Early markers of ultrafiltration failure in peritoneal dialysis: a proteomic approach Rehabilitation of somatic deficits after stroke through training and non invasive brain stimulation Genetic basis of steroid resistant nephrotic syndrome and implications for therapy SAN DONATO EST Immunology 11,5 325.000 REGINA ELENA ORD Oncology 1 Basic 11,5 326.700 Lazio ORD Bioengineering 11,5 330.000 and Technologies Lombardia ORD Oncology 1 Basic 11,5 350.000 Puglia ORD Digestive, Kidney 11,5 350.000 and Urological Systems AUXOLOGICO CLI ORD Integrative, Functional, and Cognitive 11,5 350.000 Lombardia ORD Genes, Genomes 11,5 353.000 and Genetics Pagina 116 di 332

2300285 IDENTIFICATION OF GENES REGULATING SKIN FIBROSIS IN SCLERODERMA ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Musculoskeletal, 11,5 365.000 Oral and Skin 2318281 2305841 2316155 2312246 2321791 2312101 2306233 A novel in vivo system for functional reconstitution of bone and a functional bone marrow microenvironment/hematopoietic stem cell niche: a lead into scaffold free, cell only bone regeneration strategies, and into direct modeling of leukemic and cancer st The MINA PROJECT. Mirror Neurons In Alcoholics: can Mirror Neuron System help us to understand and treat Alcohol Addiction? ZnO nanoparticles as selective killers of liver metastasis derived from colon cancer Cell characterization and analysis of the proliferative/differentiative potential of human coelomic fluid cells for "in utero" haematopoietic stem cell transplantation in haemoglobinopathies A randomized multi center study for the evaluation of efficacy and safety of two different daily doses of low molecular weight heparin (LMWH) in subjects with cancer and incidentally detected non symptomatic pulmonary embolism Toxins produced by intestinal bacteria and predisposing genetic variations: a dangerous link for colorectal cancer development? Role of Dbl in epithelial cell transformation: identification of new therapeutic targets for carcinomas Lazio ORD Vascular and 11,5 375.000 Hematology Emilia Romagna ORD Brain Disorders and 11,5 378.000 SAN MATTEO ORD Bioengineering 11,5 380.000 and Technologies Sicilia ORD Vascular and 11,5 390.000 Hematology SAN MATTEO CLI ORD Cardiovascular and 11,5 390.000 Respiratory Istituto Superiore di Sanita' EST Oncology 1 Basic 11,5 397.000 Liguria ORD Oncology 1 Basic 11,5 400.000 Pagina 117 di 332

2310910 2311565 2311686 2312459 2312195 2318117 2315068 2313834 2316816 Identification of signaling pathway activation profiles in cancer stem cells by mass cytometry, comparison with the reverse phase protein array approach and correlation with sensitivity to pathway targeting drugs. ANALYSIS OF PHERIPHERAL BLOOD DENDRITIC CELLS IN ALZHEIMER S DISEASE Beta adrenergic receptor blockade as a new, effective and safe therapy in the treatment of retinopathy of prematurity Cellular and molecular determinants of mitral valve prolapse Mitochondria involvement in synaptic dysfunction during early stage of Alzheimer's disease Protective role of high density of tumor associated macrophages in stage III colorectal cancer Identification of EphA3 as a new molecular target in multiple myeloma: opportunity for a novel therapeutic approach with a specific monoclonal antibody Does a robot assisted rehabilitation improve brain rhythms and balance in stroke and Parkinson patients? Functional topography of the spinal motor output after spinal cord injury Istituto Superiore di Sanita' ORD Oncology 1 Basic 11,5 400.000 SANTA LUCIA EST Brain Disorders and 11,5 400.000 Toscana ORD Cell Biology 11,5 405.000 MONZINO EST Cardiovascular and 11,5 405.556 Respiratory SANTA LUCIA CLI EST Brain Disorders and 11,5 407.000 HUMANITAS ORD Oncology 2 11,5 411.000 CROB ORD Oncology 1 Basic 11,5 420.000 SAN RAFFAELE PISANA CLI ORD Brain Disorders and 11,5 420.000 SANTA LUCIA ORD Integrative, Functional, and Cognitive 11,5 420.640 Pagina 118 di 332

2307175 2318270 Cotransplantation of pancreatic islets and engineered third party human umbilical cord mesenchymal stem cells. A novel approach to increase graft survival and immune tolerance in type 1 diabetes patients GABAA receptor and chloride transporter physiopathological role in ALS Toscana ORD Endocrinology, Metabolism, Nutrition and Reproductive 11,5 425.000 SANTA LUCIA ORD Molecular, Cellular, 11,5 430.000 and Developmental 2319473 Corticostriatal alterations in dopamine graft transplanted parkinsonian rats: implications for L DOPA therapy SANTA LUCIA EST Brain Disorders and 11,5 430.000 2315511 Relevant effect size of GSM electromagnetic fields (EMFs) exposure on neurophysiological and behavioural measures in subjects with mild cognitive Impairment and Alzheimer disease: a qeeg study OASI MARIA S.S. ORD Brain Disorders and 11,5 440.000 2312670 High throughput monitoring of pathogen specific cellular immunity as guidance for treatment of opportunistic infections in immunocompromised children. OSPEDALE BAMBINO GESU' CLI ORD Immunology 11,5 445.000 2307992 The dietary and genetic protection to coronary artery disease Calabria ORD Endocrinology, Metabolism, Nutrition and Reproductive 11,5 450.000 2314304 Development of innovative rapid screening methods of corticosteroids agents in cattle as growth promoters using MEA and an enhanced histopathological approach Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary 11,5 452.000 Pagina 119 di 332

2319309 The treatment adherence in children and adolescents with Spina Bifida and neurogenic bladder: relations with demographic, medical, occupational, cognitive and psycho social variables. Lombardia CLI ORD Healthcare Delivery 11,5 452.000 and Methodologies 2321296 2312713 Disruption of circadian clock and tumorigenesis SANTA LUCIA ORD Genes, Genomes and Genetics 11,5 453.000 Role of PI3K beta in cardiac remodeling and failure Piemonte ORD Cardiovascular and 11,5 474.000 Respiratory 2301480 2310165 2312614 2320180 2310625 2321455 2318249 Role of adenosine A2A receptors in the pathogenesis of Niemann Pick type C disease: a possible therapeutic target Role of TIR8 in modulating ischemia/reperfusion injury in kidney transplantation Predictive biomarkers of dementia: a longitudinal evaluation of Mild Cognitive Impairment IDENTIFICATION OF MOLECULAR MECHANISMS INVOLVED IN SYNOVIAL OSTEOCHONDROMATOSIS PATHOGENESIS Production and optimization of cartilage and bone spherules for repairing large bone losses and osteoarthritis. Brain Tumor Banking: a tool for research, diagnosis and therapy Early detection of schizophrenia related symptoms in children with 22q11.2 deletion syndrome Istituto Superiore di Sanita' ORD Molecular, Cellular, 11,5 480.000 and Developmental Lombardia ORD Immunology 11,5 490.200 FATEBENEFRATELLI ORD Brain Disorders and 11,5 495.000 Toscana ORD Musculoskeletal, 11,5 495.500 Oral and Skin Istituto Superiore di Sanita' EST Musculoskeletal, 11,5 500.000 Oral and Skin MONDINO ORD Oncology 1 Basic 11,5 525.000 Istituto Superiore di Sanita' ORD Biobehavioral and 11,5 529.444 Behavioral Processes Pagina 120 di 332

2316833 Masked mycotoxins in cereal based food products. Analytical methods, evaluation of their occurrence and risk assessment: an emerging issue for food safety? Istituto Zooprofilattico Sperimentale delle Venezie ORD Veterinary 11,5 533.000 2307183 Analysis of development and persistence of protective immunity after new and routine vaccinations in primary and secondary immunodeficiencies OSPEDALE BAMBINO GESU' ORD Immunology 11,5 534.050 2316914 2317931 2319821 Pyrimethamine derivatives: a new generation of antifolate drugs for treatment of metastatic melanoma. A preclinical study. Prediction of targeted therapies for hepatocellular carcinoma through molecular profiling of tumorous and cirrhotic tissue DELIVERY OF THERAPEUTICAL AGENTS INTO MELANOMA BY TGF β SWITCH DEPENDENT HOMING OF MESENCHYMAL STEM CELLS (MSC), ENDOTHELIAL PROGENITOR CELLS (EPC) AND ANTIGEN PRESENTING CELLS (APC) Istituto Superiore di Sanita' ORD Oncology 2 11,5 540.000 Emilia Romagna EST Oncology 2 11,5 540.000 Toscana ORD Oncology 1 Basic 11,5 550.000 2308427 EVALUATION OF CLINICAL AND EPIDEMIOLOGICAL SIGNIFICANCE OF MYCOBACTERIUM BOVIS AND MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS CELL WALL DEFICIENT FORMS IN ANIMALS, HUMANS AND FOOD SOURCES. Istituto Zooprofilattico Sperimentale della Sardegna ORD Infectious Diseases 11,5 550.000 and Microbiology 2318997 Reducing the need for intensive care unit in hospitalized patients with early respiratory failure using the non invasive ventilation technique. A multicentre randomized study. SAN RAFFAELE MONTE TABOR CLI ORD Surgical, Biomedical Imaging, and Bioengineering 11,5 550.000 Pagina 121 di 332

2317495 2308450 2315876 2314182 2315189 Involvement of Ago1 in neuronal cell fate determination and oncogenesis The added value of amyloid PET with a fluorinated radiotracer in the diagnosis of mild cognitive impairment due to Alzheimer s disease Culture and characterisation of oral mucosal and conjunctival epithelial stem cells for the reconstruction of the ocular surface in patients with bilateral limbal stem cell deficiency Rethinking neuroinflammation in sporadic AD: exploring novel therapeutic and prognostic tools Circuitry rearrangement and clinical outcome of high technological platform based restorative therapy in an ovine model of stroke: definition of microenvironment interactions and epigenetic modification contribution SANTA LUCIA ORD Molecular, Cellular, 11,5 555.000 and Developmental FATEBENEFRATELLI ORD Brain Disorders and 11,5 555.000 Veneto ORD Cell Biology 11,5 560.000 Istituto Superiore di Sanita' ORD Brain Disorders and 11,5 560.000 CARLO BESTA EST Brain Disorders and 11,5 572.300 2320842 The use of cell free fetal nucleic acids in maternal plasma for noninvasive prenatal diagnosis of monogenic diseases and screening of fetal aneuploidy SAN RAFFAELE MONTE TABOR CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 11,5 573.000 2317270 Genotoxicity, biochemical and tissutal responses in aquatic organisms exposed to chlorpyrifos and deltamethrin, assessing their risk for animal and human health Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary 11,5 576.400 2311956 The role of mineralocorticoid receptor (MR) overactivation in obesity:effects of MR blockade in human and animal models of overfeeding. SAN RAFFAELE PISANA EST Endocrinology, Metabolism, Nutrition and Reproductive 11,5 580.000 Pagina 122 di 332

2318421 Virus associated tumors: identification of novel diagnostic, prognostic and treatment strategies SAN MATTEO CLI ORD Oncology 2 11,5 580.000 2303169 Molecular determinants of immune evasion in childhood acute leukemia. OSPEDALE BAMBINO GESU' ORD Immunology 11,5 582.200 2314523 2311297 PPARgamma receptors as a treatment target for opiate addiction. Combined therapeutic cancer vaccine strategy for HCV related HCC FATEBENEFRATELLI ORD Brain Disorders and 11,5 583.600 PASCALE ORD Oncology 2 11,5 583.700 2320703 Telemedicine for monitoring of asthmatic patients Evaluation of the outcome of treatment accordin to the style of life. OSPEDALE BAMBINO GESU' CLI ORD Risk, Prevention 11,5 590.000 and Health Behavior 2318208 TAT AND ENV BIND TO FORM A NOVEL HIV ENTRY COMPLEX THAT TARGETS CELLS AT THE PORTAL OF ENTRY AND HIV RESERVOIRS: IMPLICATIONS FOR THE DEVELOPMENT OF PREVENTATIVE AND THERAPEUTIC INTERVENTIONS AGAINST HIV/AIDS Istituto Superiore di Sanita' ORD AIDS and Related 11,5 599.500 Research 2312521 Biomolecular and Biosensor innovative approaches to guarantee Protected Designation of Origin (PDO) Water Buffalo Mozzarella Cheese Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 11,5 600.000 2304111 2302035 Mucus Layer Component (Muc2) Contribute to Shape the Intestinal Immune Response Quantitative Advanced Imaging (PET/MRI) in the Surgery and Radiotherapy of High Grade Brain Tumours DE BELLIS ORD Immunology 11,5 600.000 ARCISPEDALE ORD Oncology 2 11,5 600.000 Pagina 123 di 332

2317535 Genetic and neural mechanism of Major Psychoses: the role of dopaminergic system FATEBENEFRATELLI ORD Brain Disorders and 11,5 600.000 2319881 Effect of exposure to environmental and food contaminants, on bone and liver diseases. Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 11,5 600.000 2319457 TARGETING TRIM32 AS A THERAPEUTIC APPROACH IN NEUROMUSCULAR DISEASES SANTA LUCIA ORD Cell Biology 11,5 600.000 2317660 Sharing of medical resources for the diagnosis and treatment of status epilepticus by a computer assisted telemedicine system SAN RAFFAELE MONTE TABOR CLI ORD Emerging Technologies and Training in s 11,5 600.000 2314460 Prospective Study on infectious complications in patients receiving biological drugs, either monoclonal antibodies or TNF alpha antagonists. Emilia Romagna CLI ORD Infectious Diseases 11,5 600.000 and Microbiology 2318415 Mechanism of hypertrophy in genetically determined Hypertrophic Cardiomyopathy (HCM) Lombardia EST Cardiovascular and 11,5 600.000 Respiratory 2321935 Individual risk in clinically isolated syndromes of conversion to multiple sclerosis and disease progression: an integrated public health clinical genomics approach SAN RAFFAELE MONTE TABOR CLI ORD Brain Disorders and 11,5 600.000 2311854 Effects of Testosterone supplementation on clinical and rehabilitative outcomes in older men undergoing on pump CABG Emilia Romagna CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 11,75 149.400 2312436 The role of B cells in Graft versus Host Disease after allogeneic hemopoietic cell transplantation Provincia autonoma Bolzano EST Immunology 11,75 275.000 2308387 Role of brain/cognitive reserves on neurodegenerative pathology SANTA LUCIA ORD Biobehavioral and 11,75 350.000 Behavioral Processes Pagina 124 di 332

2312695 2309052 2316913 2305781 2317061 2314880 DEVELOPMENT OF A NETWORK BASED MODEL FOR A COMPREHENSIVE CLINICAL DIAGNOSTIC MANAGEMENT OF HEREDITARY CANCER PATIENTS AND THEIR FAMILY MEMBERS Analysis of RNA processing defects in amyotrophic lateral sclerosis Tailoring micro nanocarriers structural and surface properties to finely modulate the activation or regulation of immune responses: the allergy immunotherapy proof of concept Caffeine as a potential therapeutic option for Alzheimer's disease. WHOLE EXOME SEQUENCING OF ADENOMATOUS POLYPOSIS PATIENTS FOR A GENETIC DIAGNOSIS AND CLINICAL APPLICATIONS Porcine St Valerién like caliciviruses: epidemiology, molecular characterization and zoonotic impact I. O. V. CLI ORD Healthcare Delivery 11,75 440.000 and Methodologies SANTA LUCIA ORD Genes, Genomes 11,75 515.000 and Genetics Istituto Superiore di Sanita' ORD Immunology 11,75 528.000 Istituto Superiore di Sanita' ORD Brain Disorders and 11,75 548.000 C.R.O. AVIANO ORD Oncology 1 Basic 11,75 560.000 Abruzzo CLI ORD Veterinary 12 145.000 2315044 SAFE FISH: safety and nutritional value assessment of Italian marine farmed fish Istituto Zooprofilattico Sperimentale della Sicilia ORD Healthcare Delivery 12 150.000 and Methodologies 2319327 Bacterial adhesion on orthopaedic prosthetic polyethylenes with different chemical and physical properties Piemonte ORD Infectious Diseases 12 150.000 and Microbiology 2316755 Cancer stem cell based markers of disease course and treatment resistance in stage II colon cancer patients Toscana ORD Oncology 2 12 150.000 Pagina 125 di 332

2307746 Treatment improving of Pompe disease (glycogenosis type II): new insights into chaperone and splicing correcting compounds Toscana CLI ORD Genes, Genomes 12 155.000 and Genetics 2319286 Nutritional factors in Rett syndrome and autism spectrum disorders: preclinical evaluation of dietary choline during early developmental phases Istituto Superiore di Sanita' ORD Brain Disorders and 12 159.556 2321488 2310980 2314419 2300649 2321727 2318908 EAAT2 glutamate transporter and oxidative stress studies in amyotrophic lateral sclerosis Tregs/Th17 Imbalance, Intrahepatic Cytokine Milieu and Immune Dysregulation in Autoimmune Hepatitis Therapeutic correction of mis spliced RNA transcripts and of protein conformational defects in Lysosomal Storage Disorders Implementation of cell treatments for untractable immune disorders. Correlation of immunomodulatory potency of BM MSC to the patient's immune activation and development of custom licensing strategies. Sodium channel Nav1.1: the most relevant epilepsy gene. Pathomechanisms and development of novel therapeutic strategies. Global proteomic profiling of mood disorders: search for molecular fingerprints to improve diagnosis, prognosis and guide treatment strategies. Toscana ORD Genes, Genomes 12 164.000 and Genetics Emilia Romagna ORD Immunology 12 180.000 Toscana CLI ORD Genes, Genomes 12 180.000 and Genetics BURLO GAROFALO CLI ORD Immunology 12 190.000 Lombardia EST Molecular, Cellular, 12 197.000 and Developmental Toscana CLI ORD Brain Disorders and 12 198.600 Pagina 126 di 332

2311841 2317567 2311793 2322031 Telecare and Home Care: assessing costeffectiveness of a new approach to increase safety in home care avoiding the need to hospitalize for elderly, polypathologic, chronically ill, unstable subjects with movement handicaps The reactivity to 35% CO2 challenge as predictor of pharmacological treatment outcome and relapse in Panic Disorder. Development of an in vitro assay for the diagnosis of latent tuberculosis infection (LTBI) based on a novel human immunodominant T cell epitope of the antigen PPE44 of Mycobacterium tuberculosis Interference evaluation of cancer microenvironment in the tumor specific immune response of pancreatic cancer patients Toscana CLI ORD Healthcare Delivery 12 200.000 and Methodologies Lombardia CLI ORD Biobehavioral and 12 206.200 Behavioral Processes Toscana ORD Infectious Diseases 12 214.500 and Microbiology Toscana ORD Oncology 1 Basic 12 215.500 2319303 INCIDENCE OF SUBSEQUENT SQUAMOUS CELL CARCINOMA IN NON MELANOMA SKIN CANCER ACCORDING TO SEROPOSITIVITY FOR, AND DNA PRESENCE OF, HPV. ISTITUTO DERMOPATICO DELL'IMMACOLATA CLI ORD Oncology 1 Basic 12 226.300 2305312 Isolation and characterization of interferongamma producing myeloid cells from the bone marrow of Severe Aplastic Anemia patients (SAA) GASLINI ORD Vascular and 12 232.200 Hematology 2319732 Non invasive prenatal diagnosis of genetic diseases by separation and enrichment of circulating fetal cells in maternal blood Abruzzo ORD Genes, Genomes 12 232.930 and Genetics 2317945 Impact of genetic scores derived from genomewide association studies (GWAS) on the reclassification of cardiovascular risk in the settings of primary and secondary prevention. Veneto ORD Genes, Genomes 12 239.200 and Genetics Pagina 127 di 332

2320500 2316599 Validation of a health technology for calculating fractionated doses for pediatric drugs MMP 13: a new therapeutic target in breast cancer bone metastasis Piemonte CLI EST Healthcare Delivery and Methodologies 12 240.000 C.R.O. AVIANO ORD Oncology 1 Basic 12 241.000 2312082 IR A as a new player of sarcoma malignancy RIZZOLI ORD Oncology 1 Basic 12 246.420 2312630 2309135 2314343 2318300 Flexible endoscope used in laparoscopic surgery: analysis of possible applications A Phase II Randomized Multicentre Study of SystemicChemotherapy versus Systemic Chemotherapy plus SIR Spheres as SecondLine in KRAS Mutant Unresectable Colorectal Liver Metastases (SITILO 2) mir34a: clarifying its value in prognosis and therapy of Ewing s sarcoma. Motor underpinnings to screen autism (MUSA). Prospective study on movement perception and performance in younger siblings of children with Autism Spectrum Disorders. Searching for clinical predictors and neural correlates of early autism. Veneto ORD Surgical, Biomedical Imaging, and Bioengineering 12 250.000 Lazio CLI COF Oncology 2 12 250.000 RIZZOLI ORD Oncology 1 Basic 12 251.900 STELLA MARIS CLI ORD Brain Disorders and 12 270.000 2309223 Tissue penetrating peptides coated nanoparticles as a personalized strategy for the targeted delivery of anticancer agents to solid tumors Liguria ORD Oncology 2 12 278.640 2318520 NF kb signaling pathway,innate immunity and neurodegeneration in Alzheimer's disease NEUROLESI ORD Brain Disorders and 12 280.000 Pagina 128 di 332

2313064 Pathogenetic role of B cell activating factor and novel markers of lymphoma onset in Sjögren's syndrome HUMANITAS ORD Immunology 12 280.000 2316474 Microbiological hazards in ready to eat fruit commodities Istituto Zooprofilattico Sperimentale della Sardegna ORD Veterinary 12 280.000 2318524 2315486 Use of a new material (polipropilene biofilm) with coated nanoparticles for the release of antibacterial drugs instead of surgical mesh for the reconstructive surgery of pelvic floor. Sentinel animals to monitor pollution around the former Balangero asbestos mine Lazio COF Digestive, Kidney 12 280.000 and Urological Systems Piemonte ORD Population 12 285.000 and Epidemiology 2304944 Gene expression profile at the onset of severe cardiac failure:identification and validation of new biomarkers Liguria ORD Cardiovascular and 12 290.000 Respiratory 2317740 ENHANCING ISLET TRANSPLANT SUCCESFULL BY DE NOVO TISSUE EXPRESSION OF TRUNCATED ERYTHROPOIETIN RECEPTOR. SAN RAFFAELE MONTE TABOR ORD Endocrinology, Metabolism, Nutrition and Reproductive 12 300.000 2306066 NEW DRUGS FOR BONE MASS RECOVER IN OSTEOPOROTIC PATIENTS AFFECTED BY RHEUMATOID ARTHRITIS (RA): CLINICAL/MEDICAL STUDY. Emilia Romagna ORD Musculoskeletal, 12 300.000 Oral and Skin 2318279 High Obesity risk in Children and Adults with Narcolepsy Cataplexy Istituto Scienze Neurologiche ORD Risk, Prevention 12 300.000 and Health Behavior 2321108 Characterization of the role of HIV1 Tat in establishment and maintenance of viral reservoirs: implications for new strategies toward HIV eradication Emilia Romagna ORD AIDS and Related 12 300.000 Research Pagina 129 di 332

2311379 2307452 2311515 2298967 2315045 2309250 2320019 2317376 Study of the molecular profile of circulating tumor cells for outcome prediction to docetaxel in metastatic castration resistant prostate cancer patients A phase III study (IRMA3): breast cancer at low risk of local recurrence: irradiation and accelerated partial three dimensional conformal radiotherapy (3D CRT) versus standard radiotherapy and intraoperative radiotherapy(iort) versus standard radiotherapy A comprehensive immunological strategy for the prevention of relapse in elderly patients with acute myeloid leukemia according to genotype: adoptive immunotherapy with NK cells and anti WT1 vaccination Studies on the functional role and regulation of a restricted signature of micrornas in acute myeloid leukemia Myocardial regeneration and functional recovery of the infarcted heart:role of pericardial fluids IDENTIFICATION OF MARKERS AND DEVELOPMENT OF SENSORS FOR EARLY PANCREATIC CANCER DIAGNOSIS Biological characterization of onset in Bipolar Disorder: a fmri study with BDNF polymorphisms and methylation patterns analysis in patients before and after first pharmacological treatment Diagnosis and pathogenesis of Opisthorchis felineus, an emerging foodborne parasite in Italy Emilia Romagna ORD Oncology 2 12 300.000 Emilia Romagna CLI ORD Oncology 2 12 300.000 Emilia Romagna CLI ORD Oncology 2 12 300.000 REGINA ELENA EST Oncology 1 Basic 12 300.000 SAN RAFFAELE PISANA EST Cardiovascular and 12 300.000 Respiratory Piemonte ORD Bioengineering 12 300.500 and Technologies MAGGIORE ORD Biobehavioral and 12 301.500 Behavioral Processes Istituto Superiore di Sanita' ORD Infectious Diseases 12 304.700 and Microbiology Pagina 130 di 332

2312796 THE ROLE OF MELANOPSIN RETINAL GANGLION CELLS IN PHOTOENTRAINMENT OF CIRCADIAN RHYTHMS IN NEURODEGENERATION AND AGING Istituto Scienze Neurologiche ORD Brain Disorders and 12 305.300 2312771 2307633 2316101 2314508 2319788 A prospective study on Oxaliplatin neurotoxicity: from basic science to rehabilitation looking for early preclinical signs of neuropathy. Circulating micrornas as novel biomarkers for Amyotrophic Lateral Sclerosis Dissecting the molecular regulatory networks in human myeloid derived suppressor cells. PanCareSurFupPanCare Childhood and Adolescent Cancer Survivor Care and Follow up Studies, Italian branch Controlled Ex Vivo Expansion of Human Mesenchymal Stem Cells Methodologies: A First Step Toward ly Relevant Bone Regeneration S.CAMILLO CLI ORD Oncology 2 12 316.000 Toscana ORD Brain Disorders and 12 318.000 I. O. V. ORD Immunology 12 320.000 Piemonte ORD Oncology 2 12 322.000 RIZZOLI EST Cell Biology 12 328.000 2318042 A new approach to cancer early diagnosis based on the identification of breast cancer related metabolites in human breath ISTITUTO TUMORI MILANO ORD Oncology 2 12 335.500 2309104 Development of a wearable system for the integrated assessment of seismocardiogram and other vital signs out of the laboratory setting. DON GNOCCHI ORD Bioengineering 12 341.000 and Technologies 2312718 Surveillance, control and prevention of infections by multidrug resistant organisms in alternative healthcare settings: nursing and residential homes Sicilia CLI ORD Infectious Diseases 12 345.000 and Microbiology Pagina 131 di 332

2315784 Tackling the immune system to drive muscle neoangiogenesis and regeneration: a possible tool to limit age related muscle wasting SAN RAFFAELE MONTE TABOR ORD Biology of 12 350.000 Development and Aging 2316215 Development of a novel test for detection of Bacillus anthracis DNA in urine Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata ORD Infectious Diseases 12 350.000 and Microbiology 2310896 Anti thrombogenic and antimicrobial intravascular catheters for patients hospitalized in clinical settings for neuromotor rehabilitation and long term care SANTA LUCIA CLI ORD Infectious Diseases 12 350.000 and Microbiology 2320263 Fluidodynamics of Fontan operation: A data base aiming at improvement of surgical outcome of the univentricular heart OSPEDALE BAMBINO GESU' CLI ORD Cardiovascular and 12 350.000 Respiratory 2320164 2319276 2316967 2306761 2318715 Development of novel gene therapy approaches to cure the primary ciliary dyskinesia Identification of common pathways that drive the metastatic disease through mirna profiling of transgenic mouse models and human cancers CHARGE SYNDROME: UNRAVELLING THE MOLECULAR BASES WITH TRADITIONAL AND INNOVATIVE APPROACHES G15 expression in pancreatic cancer:its prognostic and diagnostic value as a clinical/molecular marker and as a pharmacological target Potential role of TRPM8/TRPV2 channels in breast and prostate cancers: expression, biophysics and pharmacology Toscana ORD Cardiovascular and Respiratory 12 370.000 MAGGIORE ORD Oncology 1 Basic 12 376.000 Emilia Romagna ORD Genes, Genomes and Genetics 12 390.000 Veneto ORD Oncology 1 Basic 12 397.000 ONCOLOGICO DI BARI ORD Oncology 1 Basic 12 398.000 Pagina 132 di 332

2311190 HIV drug resistance in resource limited settings : an assessment in naïve pregnant women in Malawi and the evaluation of the impact of a triple antiretroviral combination strategy for PMTCT Istituto Superiore di Sanita' ORD AIDS and Related 12 400.000 Research 2314863 2315330 2319842 2311427 2315025 2315930 Identification of immunological and biochemical biomarkers of diagnostic, prognostic and therapeutic value in the management of Kawasaki disease Evaluation of new glucocorticoids and innovative combination therapy in the management of spinal cord injury Associations between ambulatory blood pressure monitoring profiles, cognitive decline, and diastolic dysfunction in the very elderly population: a multicentre study to identify novel, population specific, management algorithms. Telomere Length, Risk of Ischemic Stroke and Prediction of Poststroke Recurrent Events Hypoxia, inflammation and stem cells in cancer progression Identification of downstream targets of BAG3/BRAF mediated regulation as potential candidate markers and therapy targets in Anaplastic Thyroid Carcinoma Istituto Superiore di Sanita' ORD Immunology 12 400.000 NEUROLESI ORD Molecular, Cellular, 12 400.000 and Developmental AUXOLOGICO CLI EST Cardiovascular and 12 400.000 Respiratory NEUROLESI CLI ORD Brain Disorders and 12 408.000 SAN RAFFAELE PISANA ORD Oncology 1 Basic 12 410.000 PASCALE ORD Oncology 2 12 416.100 2308043 Role of mir in the cytokine mediated regulation of gene expression in neoplastic B cells IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 12 420.000 2311235 EPIGENETIC DETERMINANTS OF DRUG SENSITIVITY AND CLINICAL OUTCOME IN OVARIAN CANCER HUMANITAS ORD Oncology 2 12 425.000 Pagina 133 di 332

2312962 Functional ability and health related behavior among the elderly: an interactive web based surveillance system RIZZOLI CLI ORD Risk, Prevention 12 425.000 and Health Behavior 2316676 Mechanisms of interplay between Mycobacterium avium subspecies paratuberculosis and intestinal cells in Crohn s disease Istituto Zooprofilattico Sperimentale delle Venezie ORD Digestive, Kidney 12 427.900 and Urological Systems 2312255 2317866 2312702 2318828 2313970 2321389 2315480 Italian study on gene environment interactions in lymphoma aetiology: translational aspects New specific calcium inhibitor BZ194 as potential modulator of Myasthenia Gravis Next generation sequencing to speed up molecular diagnosis and to identify novel causes of hemolytic uremic syndrome Prostate cancer and visceral obesity: an epidemiological, hormonal, metabolic and molecular study Exploring the interactome of the high risk Human Papillomavirus oncoproteins to understand and dismantle its oncogenic power IDENTFICATION OF MOLECULAR MARKERS FOR EARLY DIAGNOSIS AND SCREENING OF CHRONIC ALLOGRAFT DYSFUNCTION AND IMMUNE MONITORING IN RENAL TRANSPLANT RECIPIENTS Role of mechanotransduction signals and sirtuins in rehabilitation coupled with physical activity Toscana ORD Oncology 1 Basic 12 428.000 CARLO BESTA EST Brain Disorders and 12 430.000 Lombardia ORD Genes, Genomes 12 445.200 and Genetics Veneto CLI ORD Digestive, Kidney 12 448.479 and Urological Systems REGINA ELENA ORD Oncology 1 Basic 12 448.800 Veneto ORD Genes, Genomes 12 450.000 and Genetics SAN RAFFAELE PISANA ORD Musculoskeletal, 12 450.000 Oral and Skin Pagina 134 di 332

2320697 Functional validation of candidate oncogenes in pancreatic cancer SAN RAFFAELE MONTE TABOR EST Oncology 2 12 450.000 2309773 2304365 2305042 Health (cancer and atherosclerotic) risks from radiological medical imaging in grown up congenital heart disease patients Prospective study in premanifest Huntington disease mutation carriers: new clinical and neuroradiological assessment tools for long term follow up and early signs evaluation REGENERATION OF SCAPHOID BONE DEFICIENCY BY USING AUTOLOGOUS EX VIVO EXPANDED, GMP GRADE, BONE MARROW MESENCHYMAL STEM CELLS Toscana CLI ORD Cardiovascular and 12 460.000 Respiratory CARLO BESTA CLI ORD Brain Disorders and 12 462.000 Veneto CLI ORD Surgical, Biomedical Imaging, and Bioengineering 12 465.000 2307685 Autoreactive T cell expansion profiles and mechanisms in patients with type I diabetes during beta cell replacement therapy SAN RAFFAELE MONTE TABOR ORD Immunology 12 480.000 2304930 Development of vaccines to control salmonellosis using attenuated strains with altered metal uptake capability Istituto Superiore di Sanita' EST Veterinary 12 480.000 2307645 Exploiting endoplasmic reticulum aminopeptidases modulation for innovative strategies of anticancer immunotherapy OSPEDALE BAMBINO GESU' EST Immunology 12 480.000 2313997 2317230 Large Scale Maladaptive Neuroplasticity in Chronic Migraine: Implications for Novel Neurophysiological Treatments Normal and pathological development of locomotion in the first year of life SANTA LUCIA CLI ORD Brain Disorders and 12 480.000 SANTA LUCIA ORD Brain Disorders and 12 486.640 Pagina 135 di 332

2300967 IN PURSUIT OF NOVEL THERAPEUTIC STRATEGIES FOR NON ALCOHOLIC FATTY LIVER DISEASE: UNDERSTANDING THE ROLE OF LITAF PROTEIN. OSPEDALE BAMBINO GESU' EST Digestive, Kidney 12 488.000 and Urological Systems 2319244 Collaborative model for the psychosocial care of the adult cancer patients and their caregivers: cluster, randomized trial to test a new way of care coordination. (HuCare 2: Humanization of cancer care, project 2) Lombardia CLI ORD Healthcare Delivery 12 494.444 and Methodologies 2312317 2315996 EFFECTS OF NUTRITION ON LIPID SIGNALLING IN ALZHEIMER DISEASE Differentiated cardiomyocytes as a source of induced pluripotent stem cells FATEBENEFRATELLI ORD Brain Disorders and 12 500.000 MULTIMEDICA ORD Cardiovascular and 12 524.030 Respiratory 2306183 A marker of homeostatic failure locates seizureonset CARLO BESTA ORD Brain Disorders and 12 527.000 zone in surgically remediable focal epilepsies 2321757 2301932 Endothelial Dysfunction and Insulin Resistance: an experimental and translational study on the molecular mechanisms linking endothelial dysfunction, insulin signaling and cardiovascular damage Identification of gender related differences in oxidative stress biomarkers associated with atherosclerotic disease progression Toscana ORD Cardiovascular and Respiratory 12 533.000 Istituto Superiore di Sanita' ORD Cardiovascular and 12 534.600 Respiratory 2321607 2319084 Early diagnosis in medicine by SERS nano devices Calabria ORD Bioengineering 12 535.000 and Technologies Smart biomimetic constructs with internal SAN DONATO ORD Bioengineering 12 540.000 microvasculature for stem cell based cardiac and tissue engineering: a clinical translatable approach. Technologies Pagina 136 di 332

2311296 CLINICAL AND NEUROLOGICAL MARKERS OF CHANGES IN BORDERLINE PERSONALITY DISORDER FOLLOWING A METACOGNITIVE INTERPERSONAL THERAPY FATEBENEFRATELLI ORD Brain Disorders and 12 541.675 2315966 Characterization of interactions among tumor, stromal and immune cells for the identification of potential targets in melanoma therapy. IRCCS AOU San Martino IST (Genova) ORD Immunology 12 550.000 2308743 Interactions of replicating or dormant Mycobacterium tuberculosis with human cells as a preclinical model to disclose new targets of immunointervention against tuberculosis Istituto Superiore di Sanita' ORD Immunology 12 550.000 2316270 The role of oxidative damage to DNA and its repair in human gastrointestinal cancer Istituto Superiore di Sanita' ORD Oncology 1 Basic 12 550.000 2320148 Novel immunotherapeutic strategies for the cure of human prostate cancer SAN RAFFAELE MONTE TABOR ORD Immunology 12 550.000 2318323 2319149 2304907 2318485 Priming Metabolism and Quality Control Pathways to Modulate the Cell Biology of Glioblastoma: Functional Role of the Mitochondrial Translocator Protein (TSPO) Protein profile of red blood cell and exosomes signature for early diagnosis of ovarian cancer Turning expression into advantage: a new tool for regulatory T cell therapy Sacral neuromodulation as treatment of urge incontinence in frail elderly female patients: a study of feasibility, safety and cost effectiveness analysis. REGINA ELENA ORD Cell Biology 12 551.000 Veneto ORD Oncology 2 12 560.000 BURLO GAROFALO EST Immunology 12 560.000 Lazio CLI ORD Digestive, Kidney 12 565.000 and Urological Systems Pagina 137 di 332

2312067 Extreme Obesity and Sleep Apnoea Syndrome: Redox Balance, Inflammation and Vitamin Profile. Effect of metabolic rehabilitation and non invasive mechanical ventilation. AUXOLOGICO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 12 575.000 2309615 IDENTIFICATION OF NEW DISEASE GENES IN MITOCHONDRIAL COMPLEX I DEFICIENCY OSPEDALE BAMBINO GESU' EST Brain Disorders and 12 578.000 2314204 2298392 2319883 2308317 Molecular events involved in progression from hepatitis C virus (HCV) chronic infection to hepatocellular carcinoma and in liver regeneration: mirnome and proteome analysis in experimental and clinical settings Serotonin 7 receptors: prognostic markers and new therapeutic targets for neuro developmental symptoms involving cognition, sleep and mood. Discovery of small molecules capable of eliminating the HIV T cellular reservoir Identification of new genetic variations involved in Bipolar I disorder via all exome sequencing of families with high genetic vulnerability from a founder Sardinian population Istituto Superiore di Sanita' ORD Oncology 2 12 580.000 Istituto Superiore di Sanita' ORD Biobehavioral and 12 589.000 Behavioral Processes Istituto Superiore di Sanita' ORD AIDS and Related 12 590.000 Research FATEBENEFRATELLI EST Genes, Genomes 12 599.000 and Genetics 2299674 Novel ph sensitive surfactant nanocarriers for tumor targeted drug delivery and cellular imaging as potential therapeutic and diagnostic tools for rare pediatric tumors OSPEDALE BAMBINO GESU' ORD Bioengineering 12 599.500 and Technologies 2315665 COPD global proteomics: a systems biology approach. SAN RAFFAELE PISANA ORD Cardiovascular and 12 599.999 Respiratory Pagina 138 di 332

2310397 2316512 Juvenile ALS and motor neuron degeneration: a comprehensive approach to improve diagnosis and to understand disease pathogenesis through the use of cellular and animal models Next Generation Targeted resequencing Panels as a tool for multi gene testing in the diagnosis of Parkinson Disorder MEDEA ORD Brain Disorders and 12 600.000 SAN RAFFAELE PISANA ORD Genes, Genomes 12 600.000 and Genetics 2320323 Roles of ADP ribosylation in the regulation of the actin cytoskeleton and intracellular Ca2+ signaling Abruzzo ORD Cell Biology 12 600.000 2319997 Bisphosphonates as novel adjuvants to enhance adaptive immune responses SAN RAFFAELE MONTE TABOR ORD Immunology 12 600.000 2311778 Effective functional measurements in musculoskeletal rehabilitation: guidelines, methodologies and tools for accreditation, assessment and appropriate performance of Movement Analysis Laboratories Istituto Superiore di Sanita' ORD Musculoskeletal, 12 600.000 Oral and Skin 2320776 Development of an antimicrobial food packaging by using essential oils and nanotechnology EssencePack Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 12 600.000 2321987 2313840 2314961 Scaffold assisted mesenchymal stem cells therapy for cartilage tissue engineering Investigating Huntington disease stage related biomarkers in the nervous and cardiovascular systems Individual risk for lung cancer and low dose CT Scan screening for occupationally ex exposed to asbestos. GALEAZZI EST Musculoskeletal, 12 600.000 Oral and Skin NEUROMED CLI ORD Brain Disorders and 12 600.000 Toscana CLI ORD Oncology 2 12 600.000 Pagina 139 di 332

2309532 2315085 2319774 2309741 2312752 2313261 2310701 2313877 2320251 Role of purinergic receptor P2X7R in ischemic tissue damage and collateral vessels development Prospective, Randomized, Multi Center Trial of Lateral Trendelenburg versus Semi Recumbent Body Position in Mechanically Ventilated Patients For The Prevention of Ventilator Associated Pneumonia UNRAVELING MECHANISMS UNDERLYING THE RECOVERY OF WALKING ABILITY IN STROKE SURVIVORS Hereditary spastic paraplegia: generation of cellular and animal models to dissect the complex interplay of the pathways involved combined with novel tools for disease diagnosis Adipocyte derived leptin as a new tool to manipulate immune response in Tuberculosis Health impact assessment and health care costs of respiratory tract infections (RTI) in general population and hospitalized patients in Palermo (Western Sicily). Cerebellar transcranial magnetic stimulation as a treatment option for levodopa induced dyskinesias and tremor A defect in TLR7 gene expression impaires innate and adaptive immunity in Multiple Sclerosis patients: intracellular mechanisms as therapeutic targets ALTERED HOST MICROBE INTERACTION IN HIV: A POTENTIAL TARGET FOR INTERVENTION WITH PROTICS SAN RAFFAELE PISANA EST Cardiovascular and 12 600.000 Respiratory MAGGIORE CLI EST Infectious Diseases 12 600.000 and Microbiology Emilia Romagna CLI EST Brain Disorders and 12 600.000 MEDEA EST Brain Disorders and 12 600.000 Istituto Superiore di Sanita' EST Infectious Diseases 12 600.000 and Microbiology Sicilia CLI ORD Infectious Diseases 12,25 287.500 and Microbiology NEUROMED CLI ORD Brain Disorders and 12,25 300.000 Istituto Superiore di Sanita' EST Immunology 12,25 350.000 Lombardia CLI ORD AIDS and Related 12,25 373.000 Research Pagina 140 di 332

2314371 Readthrough of Premature Termination Codons to treat Kabuki syndrome CASA SOLLIEVO SOFFERENZA ORD Genes, Genomes 12,25 395.000 and Genetics 2310258 2309128 2311331 2321379 2321864 2320903 2321866 Exploring Ng MIP Neisseria gonorrhoeae Macrophage Infectivity Potentiator) and Ng OMPA (Neisseria gonorrhoeae Outer Membrane Protein A) as novel candidates to fight gonococcal infection due to resistant or multi drug resistant gonococci Malignancy and invasiveness molecular determinants in oro pharyngeal squamous cell carcinomas. INTERMED Self Assessment Study (IMSAS) Selfassessed clinical evaluation of bio psycho social complexity Physiological effects of extracellular guanosine triphosphate (GTP) on renal cells and water transport CLINICAL IMPACT OF TISSUE AND CIRCULATING MOLECULAR MARKERS IN THE DIAGNOSIS AND FOLLOW UP OF THYROID CANCER ROLE OF PERFUSION COMPUTED TOMOGRAPHY(PCT)AND VASCULAR ENDOTHELIAL GROWTH FACTOR A(VEGF A)SERUM LEVELS IN THE MANAGEMENT OF HIGH GRADE GLIOMAS(HGG):NEW METHODS OF MONITORING TREATMENT? Exposure to occupational carcinogens and pathogenetic mechanisms in sinonasal adenocarcinomas Istituto Superiore di Sanita' ORD Infectious Diseases 12,25 400.000 and Microbiology REGINA ELENA ORD Oncology 1 Basic 12,33 441.000 Emilia Romagna CLI EST Healthcare Delivery 12,5 110.000 and Methodologies Abruzzo ORD Cell Biology 12,5 150.000 Toscana CLI ORD Oncology 2 12,5 150.000 NEUROMED CLI ORD Oncology 1 Basic 12,5 150.000 Piemonte CLI ORD Oncology 1 Basic 12,5 157.256 Pagina 141 di 332

2320321 2315861 2318072 2311277 2309687 2315222 Advanced diagnostics and innovative procedures for diagnosis and management of patients affected by Limb Girdle Muscle Dystrophies (LMGD). Role of multiple HPV infections in the development of cervical diseases. RELATIOSHIPS BETWEEN VASOACTIVE MEDIATORS AND HEMODYNAMIC ALTERATIONS IN PATIENTS WITH MULTIPLE SCLEROSIS. ULTRA HIGH FIELD(7T)MAGNETIC RESONANCE SYSTEM: NEUROMUSCOLAR APPLICATIONS Identification of biomarkers able to predict malignant transformation of dysplastic nodules in the cirrhotic liver. Nanotecnology based drug delivery : new generation nanovector for drug delivery in human bone diseases. NEUROLESI CLI ORD Musculoskeletal, 12,5 159.000 Oral and Skin BURLO GAROFALO CLI EST Infectious Diseases 12,5 175.000 and Microbiology Toscana CLI ORD Brain Disorders and 12,5 175.000 STELLA MARIS CLI EST Brain Disorders and 12,5 178.500 HUMANITAS ORD Oncology 2 12,5 179.000 GALEAZZI ORD Musculoskeletal, 12,5 190.000 Oral and Skin 2319875 Efficacy of nicotine dependence pharmacotherapy based on individual pharmacokinetic profile and identification of pharmacogenetic determinants of drug response Toscana CLI ORD Brain Disorders and 12,5 190.000 2308589 TOOLS FOR THE IMPROVEMENT OF ADHERENCE TO MEDITERRANEAN DIET AND PHYSICAL ACTIVITY IN PATIENTS WITH CARDIOVASCULAR DISEASES: AN INTERVENTION STUDY DON GNOCCHI CLI ORD Risk, Prevention 12,5 194.000 and Health Behavior Pagina 142 di 332

2315238 2316544 2310539 2313206 2316531 2318403 2317578 Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in mantle cell lymphoma (MCL) treated with R HDS The therapeutic potential of natural and synthetic agonists of PPAR gamma as adjuvant and dietary supplementations in the cure of demyelinating diseases Experimental studies and preclinical applications of Endothelial Differentiation of Amniotic Fluid Derived Stem Cells : a promising new therapeutic strategy for stroke MOLECULAR EVENTS IN MELANOMA PROGRESSION: REGULATION OF AP 2 TARGET GENES AND INVOLVEMENT IN TUMOR GROWTH AND METASTASIS. Humanization of Emergency Departments in Local Healthcare Authority TO3 Piedmont Region: new features and patient satisfaction Effect of matrix metalloproteinases on the integrity and functions of anti tumor necrosis factor (TNF) alpha agents: possible correlation with response to anti TNF alpha treatment in inflammatory bowel disease patients ANALYSIS OF PROGNOSTIC AND PREDICTIVE FACTORS AND DEVELOPMENT OF AN ONCOMETABOLITE AS MARKER IN PATIENTS WITH MALIGNANT GLIOMAS Lombardia ORD Interdisciplinary 12,5 200.000 Molecular and Training Istituto Superiore di Sanita' ORD Molecular, Cellular, 12,5 215.000 and Developmental Abruzzo ORD Emerging Technologies and Training in s 12,5 222.200 Piemonte ORD Oncology 2 12,5 240.000 Piemonte CLI ORD Healthcare Delivery 12,5 241.000 and Methodologies SAN MATTEO ORD Digestive, Kidney 12,5 250.000 and Urological Systems I. O. V. ORD Brain Disorders and 12,5 290.000 2321227 Unravelling the susceptibility to develop rotator cuff tears and its role onto surgical outcome OSPEDALE BAMBINO GESU' CLI EST Musculoskeletal, 12,5 290.000 Oral and Skin Pagina 143 di 332

2318463 2311876 2317163 2317624 2321885 The ADP receptor P2Y13 in the regulation of megakaryocytes development in myeloproliferative neoplasms Pharmacological approaches to improve the thymic defect and prevent autoimmunity in a murine model of Omenn syndrome: therapeutic implications. Modularity for sensory motor control: implications of muscles synergies in motor recovery after stroke. Effects of high intensity robot assisted training in hand function recovery and ADL independence after stroke: a multicentre randomized controlled single blind trial FK 506 Pharmacogenetics/Pharmacogenomics and new approaches in FK 506 therapeutic drug monitoring in pediatric and adult liver transplantation Lombardia CLI ORD Vascular and 12,5 291.000 Hematology HUMANITAS ORD Immunology 12,5 293.000 S.CAMILLO CLI EST Biobehavioral and 12,5 294.000 Behavioral Processes SAN RAFFAELE PISANA CLI ORD Brain Disorders and 12,5 299.896 Piemonte EST Immunology 12,5 300.000 2310585 Identification and evaluation of markers of malignancy in thyroid nodules with undetermined cytology BURLO GAROFALO CLI ORD Oncology 1 Basic 12,5 300.000 2311179 Transcranial magnetic stimulation over parietal cortex to restore altered somatosensory processing in patients with dystonia. NEUROMED CLI ORD Brain Disorders and 12,5 300.000 2321031 Validation of a new algorithm for HPV status assessment in head and neck carcinoma ISTITUTO TUMORI MILANO CLI ORD Oncology 2 12,5 303.600 2316132 Functional studies of deregulated micrornas in Sezary Syndrome ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Oncology 1 Basic 12,5 312.000 Pagina 144 di 332

2319750 2314998 2306200 Biological aging in dilated cardiomyopathy and chronic obstructive pulmonary disease Strategies to improve functional recovery in presence of cerebellar pathology Relevance of host factors in the pathogenesis of HCV related lymphoproliferative disorders Veneto ORD Cardiovascular and 12,5 348.000 Respiratory SANTA LUCIA ORD Biobehavioral and 12,5 350.000 Behavioral Processes Toscana ORD Oncology 1 Basic 12,5 350.000 2308228 Effects of Neuropeptide Y on the central nervous SANTA LUCIA ORD Brain Disorders and 12,5 350.000 system neurons of rat models of Alzheimer Disease 2317676 ROLE OF WT1 AND ITS ISOFORMS IN HEMATOPOIETIC MALIGNANCIES SDN CLI ORD Genes, Genomes 12,5 350.000 and Genetics 2306948 CLINICAL AND PHARMACOLOGICAL EVALUATION OF TRABECTEDIN (T) IN BRCA MUTATION CARRIER AND BRCANESS PHENOTYPE OVARIAN CANCER PATIENTS ISTITUTO TUMORI MILANO CLI ORD Oncology 2 12,5 350.000 2310959 2317940 Development of a novel lubricating gel containing antimicrobial loaded nanoparticles to prevent urinary catheter associated infections particularly in patients with neurogenic bladder requiring long term catheterization. WAC Project (Web Based Asthma Control) evaluation of the utility of a web based electronic health diary to improve control of moderatesevere asthma SANTA LUCIA CLI ORD Infectious Diseases and Microbiology 12,5 350.000 Toscana CLI ORD Cardiovascular and 12,5 350.000 Respiratory 2311328 A PROSPECTIVE STUDY TO EVALUATE THE INFLUENCE OF GENETIC VARIATIONS IN ATM, OCT and MATE GENES IN THE GLYCAEMIC RESPONSE TO METFORMIN IN DRUG NAÏVE TYPE 2 DIABETIC PATIENTS AUXOLOGICO ORD Genes, Genomes 12,5 353.000 and Genetics Pagina 145 di 332

2303770 2314819 2307545 2302480 2317525 2312034 2314813 2317339 Role of Human Papilloma Virus in Head and Neck Cancer. A model for benchmarking cancer care management among different organizational settings in view of harmonization mirnas controlling telomere function in cancer "telo mirnas" MicroRNA replacement therapy for the treatment of Neuroblastoma Seven In Absentia Homologue (SIAH) Interaction with Na+/Ca2+ Exchanger and A Kinase Anchoring Protein (AKAP) to Identify new Druggable Targets for the Treatment of Cerebral Ischemia The endocannabinoid system as target in colon cancer and associated cachexia MEDITERRANEAN DIET, PHYTO ESTROGENS AND RECURRENCE OF COLORECTAL ADENOMAS. A MULTICENTER RANDOMIZED CONTROLLED TRIAL. PLASMA EXOSOMES IN THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES: MiRNA SEQUENCING AND PROTEOMICS I.E.O. EST Infectious Diseases 12,5 360.000 and Microbiology Piemonte CLI ORD Healthcare Delivery 12,5 360.000 and Methodologies Lazio ORD Oncology 1 Basic 12,5 390.000 Liguria ORD Oncology 2 12,5 397.980 SDN ORD Molecular, Cellular, 12,5 398.000 and Developmental NEUROLESI ORD Digestive, Kidney 12,5 400.000 and Urological Systems DE BELLIS EST Oncology 2 12,5 400.000 Istituto Superiore di Sanita' ORD Brain Disorders and 12,5 422.000 2316309 Definition of the prognostic and biological roles of tissue associated and soluble biomarkers in epithelial ovary cancer exploiting well characterized retrospective and prospective clinical series of samples ISTITUTO TUMORI MILANO ORD Oncology 2 12,5 425.800 Pagina 146 di 332

2318894 BOOSTING COGNITIVE FUNCTIONS IN ADHD PATIENTS USING NON INVASIVE ELECTRICAL STIMULATION OSPEDALE BAMBINO GESU' ORD Integrative, Functional, and Cognitive 12,5 449.900 2319127 Nociceptin/Orphanin FQ as a biomarker for Parkinson s disease Friuli Venezia Giulia CLI ORD Brain Disorders and 12,5 450.000 2313981 Whole genome study of gastrointestinal stromal tumors (GISTs), abdominal soft tissue sarcoma and rare tumors using next generation DNA sequencing approach for optimizing the diagnosis, prognosis, classification and treatment Emilia Romagna ORD Oncology 1 Basic 12,5 456.000 2313125 2316169 2317012 2310065 2316744 The role of microbial agents in prostate cancer pathogenesis Dissecting the molecular bases and clinical variability of familial Alzheimer's disease Arbovirus infections in humans and vectors: potential for local outbreaks in Northern Italy EBV reactivation and CD8+ T cell responses in Multiple Sclerosis Sensory plasticity of the adult human brain and recovery after stroke: behavioural and neurophysiological markers C.R.O. AVIANO EST Oncology 2 12,5 463.290 Istituto Superiore di Sanita' ORD Brain Disorders and 12,5 464.000 SAN MATTEO ORD Infectious Diseases 12,5 470.000 and Microbiology SANTA LUCIA CLI ORD Immunology 12,5 470.000 FATEBENEFRATELLI ORD Brain Disorders and 12,5 474.100 2318977 Microbiota induced MAIT cells and Autoimmunity SANTA LUCIA ORD Immunology 12,5 475.000 Pagina 147 di 332

2315985 2318212 2316749 The mutant p53/id4 axis controls the cross talk between breast cancer cells and tumor associated macrophages: study of its involvement in the control of tumor neoangiogenesis and invasiveness. Home based palliative care for people with severe multiple sclerosis: Developmental and pilot phases of the Palliative Network for Severely Affected Adults with MS in Italy (PeNSAMI) study Role of dual purinergic/cysteinyl leukotrienes receptor GPR17 in inflammatory conversion of cardiac resident progenitors following myocardial ischemia REGINA ELENA ORD Oncology 1 Basic 12,5 480.000 CARLO BESTA CLI ORD Brain Disorders and 12,5 484.660 MONZINO ORD Cardiovascular and 12,5 495.000 Respiratory 2300675 Harnessing Innate Immunity Against Influenza A: Investigation of Tripartite Motif 22 Mediated Inhibition of Viral Replication SAN RAFFAELE MONTE TABOR ORD Infectious Diseases 12,5 495.750 and Microbiology 2320668 Role of alternative polyadenylation in cancer SANTA LUCIA ORD Genes, Genomes 12,5 500.000 and Genetics 2308033 2312240 2306394 2317413 GADD45beta cell permeable inhibitor peptide against cerebral ischemia Molecular characterization of the epithelialmesenchimal transition process underlying idiopathic pulmonary fibrosis and lung cancer. Mechanisms of mood control by inflammatory cytokines in Multiple Sclerosis. micrornas as early biomarkers of anthracyclines induced cardiotoxicity Lombardia ORD Brain Disorders and 12,5 500.000 SAN MATTEO EST Cardiovascular and 12,5 500.000 Respiratory SANTA LUCIA CLI ORD Brain Disorders and 12,5 500.000 MONZINO ORD Cardiovascular and 12,5 518.400 Respiratory Pagina 148 di 332

2299929 Whole transcriptome changes induced by vaccineelicited immune responses in melanoma patients: providing the rationale for the development of dynamic antigen updating of dendritic cell vaccines Emilia Romagna ORD Immunology 12,5 525.000 2311097 Mast cells translate external challenges into immune regulation affecting colitis and colorectal cancer. ISTITUTO TUMORI MILANO ORD Immunology 12,5 539.500 2320571 2306558 2319157 2314831 Pathogenesis of West Nile virus infection: a balance between virulence, innate immunity and viral evasion Characterization of new molecular mechanisms responsible for drug resistance and novel biomarkers predictive of the individual response to therapy in human breast and ovarian cancers Inflammation and cancer: relevance of chemokines in myeloid cells recruitment, activation and cross talk with NK cells in tumor biology Understanding the adaptive immune response defects of WHIM syndrome patients Emilia Romagna ORD Infectious Diseases 12,5 540.000 and Microbiology CROB ORD Oncology 2 12,5 540.000 HUMANITAS ORD Immunology 12,5 550.000 HUMANITAS ORD Immunology 12,5 550.000 2304806 Multiple gene analysis in bronchoscopic specimens from patients with advanced non small cell lung cancer I.E.O. CLI ORD Oncology 2 12,5 550.000 2318338 Isolation and characterization of ependymalderived stem/progenitor cells (epspcs): a new in vitro model to address pathogenesis and treatment of motor neuron diseases. CARLO BESTA ORD Brain Disorders and 12,5 558.750 Pagina 149 di 332

2317767 2317081 2305115 Immunogenic cell death as predictive and realtime marker of response to EGFR targeted therapy in CRC patients Exploring the role of drusen in the retinas as possible markers for the Alzheimer s disease pathology: a multidisciplinary approach. Pathway association and genetic interaction analysis for genome wide association study of cerebrovascular ischemic diseases in the Italian population I.E.O. ORD Oncology 2 12,5 560.000 Istituto Superiore di Sanita' ORD Brain Disorders and 12,5 570.000 CARLO BESTA CLI EST Genes, Genomes 12,5 571.100 and Genetics 2309714 ENDOGENOUS OUABAIN IS IMPLICATED IN ACUTE KIDNEY INJURY IN CARDIAC SURGERY AND CRITICALLY ILL PATIENTS: A METABOLOMIC STUDY SAN RAFFAELE MONTE TABOR CLI ORD Digestive, Kidney 12,5 575.000 and Urological Systems 2321187 IDENTIFICATION OF NEW DISEASE GENES ASSOCIATED WITH BRUGADA SYNDROME BY WHOLE EXOME SEQUENCING SAN RAFFAELE MONTE TABOR CLI ORD Cardiovascular and 12,5 580.000 Respiratory 2320365 Identification of clinical and genetic factors for personalized opioid therapy of cancer pain ISTITUTO TUMORI MILANO CLI ORD Oncology 2 12,5 580.800 2312613 2304752 Phenotypic characterization and genomic sequencing in schizophrenia Estrogen and Gender Biased Autoimmunity in Systemic Lupus Erythematosus SAN RAFFAELE PISANA EST Genes, Genomes 12,5 593.000 and Genetics Istituto Superiore di Sanita' ORD Immunology 12,5 600.000 2315673 Molecular and Functional Characterization of a Polycystin/Nephrocystin Complex SAN RAFFAELE MONTE TABOR ORD Digestive, Kidney 12,5 600.000 and Urological Systems 2320678 A proteomic and lipidomic approach to discover diagnostic and predictive markers of lung cancer. Emilia Romagna ORD Oncology 2 12,5 600.000 Pagina 150 di 332

2315099 Predictive biomarkers of melanoma progression and clinical response to chemoimmunotherapeutic therapies using new medical imaging approaches SAN GALLICANO ORD Oncology 2 12,5 600.000 2307803 CREATION OF A NATIONAL NETWORK FOR Emilia Romagna CLI ORD Oncology 2 12,5 600.000 THE DIAGNOSIS OF MALIGNANT LYMPHOMAS 2317211 2315101 Predictive value of FDG PET/CT Metabolic Tumour Volume in patients treated with neoadjuvant chemoradiation therapy for locally advanced rectal cancer Co Amplification of the ERBB2 and RARA genes in breast cancer: a potential target for retinoidbased therapy Liguria CLI ORD Oncology 2 12,5 600.000 MAUGERI CLI ORD Oncology 2 12,5 600.000 2319773 Evaluation of the effectiveness of ADL based exercises Vs point to point reaching tasks in robot mediated therapy of the upper limb for subacute stroke patients SAN RAFFAELE PISANA CLI ORD Emerging Technologies and Training in s 12,5 600.000 2321047 2317171 FRACTURE UNIT MULTIREGIONAL EXPERIMENTATION PROJECT (FRAME Project) ACUTE INFLAMMATORY LEUKOENCEPHALOPATHIES: A MULTIDISCIPLINARY STUDY ON AETIOPATHOGENETIC MECHANISMS AND IDENTIFICATION OF DISEASE MARKERS Toscana CLI ORD Healthcare Delivery 12,5 600.000 and Methodologies MONDINO CLI ORD Brain Disorders and 12,5 600.000 2308854 Development and assesment of a regional palliative care network. The Ligurian Palliative Care Demonstration Project. IRCCS AOU San Martino IST (Genova) CLI ORD Healthcare Delivery 12,5 600.000 and Methodologies Pagina 151 di 332

2317800 Role of stromal cells in lymphoma mediated immunosuppression: a novel target for the treatment. IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 12,63 300.000 2311457 Parkinson's Disease: a new approach to motor and cognitive neurorehabilitation FATEBENEFRATELLI ORD Brain Disorders and 12,63 595.000 2307785 Integrated risk assessment for food safety emerging risks in sustainable farming systems (IRASF) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary 12,67 600.000 2321373 Investigation of B cell function and diversity in patients with SCID X1 following HSCT or gene therapy Toscana EST Immunology 12,75 195.000 2319865 Characterization of behavioral and neuronal SANTA LUCIA ORD Brain Disorders and 12,75 320.000 alterations in the prodromal phase of Parkinson's disease to prevent dopamine neurons degeneration 2316044 2314957 NON INVASIVE BRAIN STIMULATION AS ADJUVANT THERAPY FOR ALZHEIMER DISEASE Adipose tissue remodelling from white to brown phenotype as preventive treatment for type 2 diabetes and as potential tool to protect against metabolic diseases of aging. MAGGIORE CLI ORD Brain Disorders and 12,75 337.000 SAN RAFFAELE PISANA ORD Endocrinology, Metabolism, Nutrition and Reproductive 12,75 400.000 2304946 Contribution of fibroblast derived micrornas to prostate and lung cancer aggressiveness ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 12,75 450.000 2318619 The role of PlGF/VEGFR1 pathway in the regulation of inflammatory response and vascular rarefaction in hypertension. NEUROMED ORD Vascular and 12,75 490.000 Hematology Pagina 152 di 332

2319225 STem cells Mobilization in Acute Myocardial Infarction Outcome Trial (STEM AMI OUTCOME Trial): efficacy and functional substudies Lombardia CLI ORD Cardiovascular and 12,83 400.000 Respiratory 2303759 2310301 2321841 2309364 2312388 2321827 2321411 2310304 Evaluation of a multi marker strategy in the clinical management of children with congenital heart disease undergoing cardiac surgery. Integrated lipidomic profiling in diabetes, cardiovascular disease and cancer in a cohort of subjects in a mediterranean area of southern Italy: a nested case control study. BDNF polymorphism, calprotectin and clinical phenotype in Rett syndrome Identification of novel causative genes for developmental brain disorders mapping in the 6q27 chromosomal region. Modeling Alzheimer s disease through ips technology A randomized intervention study to assess the effect of the Mediterranean Diet on plasma fatty acid profile. Role of mir 155 in FLT3 ITD mutated acute myeloid leukemia: studies of network, signalling and silencing. GOAL DIRECTED PERFUSION AND ACUTE KIDNEY INJURY IN CARDIAC SURGERY A RANDOMIZED, CONTROLLED TRIAL Toscana ORD Cardiovascular and 13 123.000 Respiratory DE BELLIS COF Population 13 150.000 and Epidemiology Toscana CLI ORD Brain Disorders and 13 150.000 Toscana CLI ORD Brain Disorders and 13 150.700 FATEBENEFRATELLI ORD Brain Disorders and 13 163.000 MONZINO CLI ORD Cardiovascular and 13 174.900 Respiratory Sicilia ORD Oncology 1 Basic 13 180.000 SAN DONATO CLI COF Surgical, Biomedical Imaging, and Bioengineering 13 185.000 Pagina 153 di 332

2315152 2318462 Internet addiction disorder in adolescents: identification of possible biological and personality markers Sgk1: a novel regulator of genomic stability in human cancer Toscana ORD Brain Disorders and 13 194.000 Calabria ORD Oncology 1 Basic 13 200.000 2321579 Bone structure in blood malignancies IRCCS AOU San Martino IST (Genova) ORD Bioengineering 13 200.000 and Technologies 2311327 2310739 2310035 2314589 2305907 2319049 Molecular markers and pathogenic mechanisms of the emerging Beijing genotype of Mycobacterium tuberculosis Novel therapeutic perspectives for angioedema associated with C1 inhibitor deficiency or angiotensin converting enzyme inhibitor treatment Characterization and validation of new prognostic markers in high grade ovarian cancer. Modulation of pharmacogenomic and pharmacodynamic biomarkers of glucose metabolism by metronomic chemotherapy in cancer and endothelial cells Modulation of immune (T cell) response to islet autoantigens by human mesenchymal stem cellderived microvesicles Prediction of reading acquisition disorders using behavioral and neurobiological markers Toscana ORD Infectious Diseases 13 200.000 and Microbiology BURLO GAROFALO CLI ORD Vascular and 13 220.000 Hematology C.R.O. AVIANO ORD Oncology 1 Basic 13 227.800 Toscana EST Oncology 2 13 240.000 Piemonte ORD Immunology 13 250.000 MEDEA CLI ORD Risk, Prevention 13 250.000 and Health Behavior 2318203 Haemophilia arthropathy (HA) and Ultrasound (US): development and first validation steps of the simplified HEAD US score Liguria CLI COF Musculoskeletal, 13 264.810 Oral and Skin Pagina 154 di 332

2317331 2310610 2315722 2317481 2318533 2320268 2318666 Towards communication in vegetative and minimally conscious state patients. Semantic classical conditioning and brain computer interface control CONFOCAL MICROSCOPY TO ENHANCE THE TREATMENT OF EPITHELIAL SKIN CANCERS Effects of conventional rehabilitation terapy and combined restorative interventions in patients with post stroke deficits of the upper limb ROLE OF HOST AND VIRAL FACTORS ON THE EXPERIMENTAL INFECTIONS OF CYNOMOLGUS MACAQUES WITH SIMIAN OR SIMIAN HUMAN IMMUNODEFICIENCY VIRUS. Evaluation of chemotherapy induced cardiotoxicity utilizing cardiac byomarkers doppler echocardiography and Magnetic Resonance Imaging Indoleamine 2,3 Dioxygenase and Peripheral Tolerance to Exogenous Factor VIII:A Multi Centre Study Multiplex Ligation Probe Amplification (MLPA) analysis, 5p 13.2 Loss Of Heterozygosity (LOH),CA SSR1 EGFR microsatellite analysis and NIPBL Illumina Solexa sequencing in Thymic Epithelial Tumors and Squamous Cell Lung Carcinomas metastatic to the medias S.CAMILLO CLI ORD Biobehavioral and 13 265.500 Behavioral Processes MAUGERI CLI ORD Surgical, Biomedical Imaging, and Bioengineering 13 266.156 S.CAMILLO CLI ORD Brain Disorders and 13 270.000 Istituto Superiore di Sanita' ORD AIDS and Related 13 274.400 Research Lazio ORD Brain Disorders and 13 280.000 Umbria EST Vascular and 13 284.000 Hematology REGINA ELENA ORD Oncology 1 Basic 13 285.000 Pagina 155 di 332

2313266 FROM HUMAN TO CANINE. SERUM TUMOUR MARKERS EXPRESSION IN MAMMARY CANCER: NEW PERSPECTIVE IN VETERINARY ONCOLOGY? Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary 13 287.000 2317491 ROLE OF NEUROPILIN 1 IN THE PROGNOSIS AND THERAPEUTICS OF HUMAN MELANOMA ISTITUTO DERMOPATICO DELL'IMMACOLATA ORD Oncology 1 Basic 13 287.000 2315661 2313886 Continuity of mental disorders from childhood to early adulthood in Emilia Romagna and Piemonte: comparison with the Danish population Longitudinal advanced EEG evaluation and noninvasive neuromodulation in patients in vegetative state Emilia Romagna CLI ORD Risk, Prevention 13 290.000 and Health Behavior Sicilia CLI ORD Brain Disorders and 13 299.795 2312569 2318589 2315570 2319238 2316161 Therapeutic potential of High Density Lipoprotein (HDL) associated lysosphingolipids in arteriosclerosis Biological and biomechanical experimentation using a new vetro ceramic scaffold for bone regeneration in order to evaluate surgical and pharmacological treatments before testing on the patient. Nitrosation of drugs of abuse in human saliva at the acidic ph of the stomach: mechanism of transformation and evaluation of associated carcinogenic risk New candidate gene for hemiplegic migraine and episodic ataxia Autophagy: a pro apoptotic or pro survival pathway in Amyotrophic Lateral Sclerosis (ALS)? Emilia Romagna ORD Vascular and 13 300.000 Hematology Piemonte ORD Bioengineering 13 300.000 and Technologies Istituto Superiore di Sanita' ORD Oncology 1 Basic 13 300.000 Lazio ORD Genes, Genomes 13 300.000 and Genetics SANTA LUCIA ORD Molecular, Cellular, 13 300.000 and Developmental Pagina 156 di 332

2318008 2303152 2317184 2317243 2302935 FORCING THE BLOOD BRAIN BARRIER FOR CANCER CHEMOTHERAPY Neurophysiologic, genetic and neuroimaging features of Gilles de la Tourette Syndrome and Obsessive Compulsive Disorder Metabotropic glutamate receptors as a target for the treatment of Amyotrophic Lateral Sclerosis Type 3 metabotropic glutamate receptors expressed by cancer stem cells as drug targets in the experimental treatment of malignant gliomas The response to intestinal microbiota in peripheral blood and gut mucosa from patients with Crohn's Disease: from the definition of immune profiles to the development of induced pluripotent stem cells for pharmacologic studies. Toscana ORD Oncology 2 13 300.000 NEUROMED CLI ORD Brain Disorders and 13 300.000 NEUROMED COF Brain Disorders and 13 300.000 NEUROMED COF Brain Disorders and 13 300.000 BURLO GAROFALO CLI ORD Digestive, Kidney 13 300.000 and Urological Systems 2320495 Phase II trial of fulvestrant and gefitinib combination in patients with EGFR mutations who failed a first line with EGFR Tyrosine Kinase Inhibitors (TKIs) ISTITUTO TUMORI MILANO CLI COF Oncology 2 13 304.800 2314768 2318453 Safety and technology assessment of Ultra High Field Magnetic Resonance 7 Tesla System for children applications A randomized multicenter study to compare the efficacy of additional tumor debulking surgery versus chemotherapy (CT) alone for recurrent platinum(p) sensitive ovarian cancer (OC) STELLA MARIS ORD Surgical, Biomedical Imaging, and Bioengineering 13 305.000 PASCALE CLI ORD Oncology 2 13 308.000 Pagina 157 di 332

2304552 2315306 2317438 2318690 2310686 2309920 2307698 Investigation of the expression and functional role of caveolin 1 and Polymerase I and Transcript Release Factor (PTRF)/cavin 1 in rhabdomyosarcomas. "Distribution of allelic polymorphism (TAAA)n in the Sex Hormone Binding Globulin (SHBG) gene in breast cancer patients with or without hormone therapy:relations with SHBG plasma levels and nutrictional factors". Functional and effective connectivity evaluation in drug resistant epileptic patients candidates to surgery.a new tool for identification of the seizure onset zone and prediction of memory and cognitive outcome. DEVELOPMENT IN ACUTE MYELOID LEUKEMIA PATIENTS OF A GENOMIC TEST BASED ON PROFILING OF APOPTOTIC MACHINERY AND OF mi RNA FOR REFINEMENT OF PROGNOSTIC RISK CLASSIFICATION AND TO GUIDE POST REMISSIONAL THERAPEUTIC STRATEGY Ex vivo studies on hyperhomocysteinemiainduced epigenetic modifications as potential biomarkers for early diagnosis of Alzheimer s disease and other dementia related disorders Fatigue relief in Multiple Sclerosis by transcranial Direct Current neurostimulation (tdcs). [FaMuSne] Mechanisms and actions of Regorafenib, a new hepatoma (HCC) therapy Lombardia ORD Oncology 1 Basic 13 315.000 ONCOLOGICO DI BARI CLI ORD Genes, Genomes 13 315.000 and Genetics Toscana CLI ORD Brain Disorders and 13 320.000 Sicilia ORD Oncology 2 13 326.000 Sicilia ORD Molecular, Cellular, 13 328.000 and Developmental SAN RAFFAELE PISANA ORD Brain Disorders and 13 336.000 DE BELLIS ORD Oncology 2 13 349.000 Pagina 158 di 332

2314048 The development and progression of Mild Cognitive Impairment in Parkinson s disease: a multimodal neuroimaging study to detect markers able to predict the conversion to dementia. SAN RAFFAELE MONTE TABOR CLI ORD Biobehavioral and 13 350.000 Behavioral Processes 2309338 2315715 2309014 2304955 Analysis of pattern recognition receptor activation in cognitively impaired subjects ELUCIDATION OF IN VIVO CORRECTION TO WILDTYPE MECHANISM OF HERITABLE MUTATIONS IN HUNTER DISEASE Identification and pathways to care of children with complex or chronic health conditions and special health care needs Whole exome resequencing in familial Neural Tube Defects SANTA LUCIA EST Brain Disorders and 13 354.440 GASLINI ORD Genes, Genomes 13 360.000 and Genetics Emilia Romagna CLI ORD Healthcare Delivery 13 360.000 and Methodologies GASLINI ORD Genes, Genomes 13 362.000 and Genetics 2315210 Therapeutic strategies in refractory chronic daily headache: A multicenter, open, randomized, controlled trial. Istituto Scienze Neurologiche CLI ORD Emerging Technologies and Training in s 13 364.000 2311436 2316293 2314162 Gender related differences in fibromyalgia: role of oxytocin mediated neurotransmission Colorectal cancer: Vitamin D, VDR and beta Catenin expression study: from biological pathways to clinical prevention. Proteomics of benign and malignant parathyroid tumors: identification of molecular and humoral biomarkers for early diagnosis of sporadic and familial parathyroid cancer FATEBENEFRATELLI ORD Molecular, Cellular, 13 379.203 and Developmental I.E.O. CLI ORD Oncology 2 13 389.000 Toscana ORD Oncology 1 Basic 13 400.000 Pagina 159 di 332

2316987 The PDE5 cgmp PKG system in adipose tissue: a potential novel target for therapies aimed to fight obesity and metabolic syndrome SAN RAFFAELE PISANA ORD Endocrinology, Metabolism, Nutrition and Reproductive 13 400.000 2321574 2319666 2315562 Genomic approach to understand hereditary angioedema as a periodic disease triggered by stress. Investigation on the molecular correlates of autonomic nervous system stimulation Potential relevance of HLA G, gelatinases and herpes viruses as markers of tumor invasion and progression and their association with CT and MRI perfusion findings in patients with high grade glioma Hydrogen sulphide (H2S) as a novel player in endothelial dysfunction associated to hypertension Lombardia ORD Genes, Genomes 13 400.000 and Genetics Emilia Romagna ORD Brain Disorders and 13 400.000 SAN RAFFAELE PISANA ORD Cardiovascular and 13 400.000 Respiratory 2305545 2315369 2315224 TLR2 at the crossroads between infections and Multiple Sclerosis in human and experimental pathology Effect of dopamine treatment on neurocognitive functioning in Parkinson s disease: a fmri study Effects of pharmacological/non pharmacological interventions on collateral flow in acute ischemic stroke Lazio EST Immunology 13 400.000 SANTA LUCIA EST Brain Disorders and 13 400.000 Lazio CLI ORD Brain Disorders and 13 400.000 2315997 Virus evolution and virus host interaction in the pathogenesis of severe influenza virus A infections SAN MATTEO ORD Infectious Diseases 13 405.000 and Microbiology 2320177 From personality to molecular mechanisms through neurocognitive phenotypes: a translational study of liability to compulsive drugseeking SANTA LUCIA EST Brain Disorders and 13 413.600 Pagina 160 di 332

2319661 2319617 2318123 2316125 Novel combinatorial therapeutic approach targeting cancer associated fibroblasts derived GDF15 protein in prostate cancer models Combined use of transcranial direct current stimulation and speech therapy to treat patients with aphasic stroke: short and long term effects on anomia Prediction of cerebral outcome after extracorporeal circulation: a combined EEG TMS study Involvement of dysregulated OPG/RANK/RANKL axis in atherogenesis and acute coronary syndromes PASCALE ORD Oncology 1 Basic 13 420.000 MAUGERI CLI ORD Emerging Technologies and Training in s 13 420.000 SAN RAFFAELE PISANA CLI ORD Brain Disorders and 13 444.000 Veneto ORD Vascular and 13 445.000 Hematology 2316438 Development and evaluation of a reverse transcriptase Real Time PCR assay for the study of the presence of viable Toxoplasma gondii in vegetable and meat Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary 13 450.000 2319190 2314647 2319975 Understanding the function of WRNIP1 in the maintenance of common fragile site stability and in lung cancer development Identification of new prognostic factors for disease outcome in a regional cohort of patients with B cell chronic lymphocytic leukemia (B CLL) Identification of measurable biomarkers of vascular ageing: a System Biology Approch Istituto Superiore di Sanita' ORD Oncology 1 Basic 13 450.000 Veneto ORD Vascular and 13 450.000 Hematology Puglia ORD Vascular and 13 450.000 Hematology 2314734 User participation in payment of health treatments(co payement) Agenzia per i Servizi Sanitari Regionali CLI ORD Healthcare Delivery 13 450.000 and Methodologies Pagina 161 di 332

2313069 2312770 2315976 2321033 2321524 2310843 Cytoreduction and Hipec in the treatment of OvaRIaN cancer CHORINE StudyStage IIIC unresectable epithelial ovarian/tubal cancer with partial or complete response after 1st line neoadjuvant chemotherapy (3 cycles CBDCA+Paclitaxel): a phase 3 pros CHRONIC KIDNEY DISEASE (CKD) AND CARDIOVASCULAR RISK. MOLECULAR MECHANISMS, CLINICAL IMPLICATIONS AND NEW PREVENTIVE STRATEGIES Splicing variants of L1CAM in human cancer cells: functional relevance in modulating NK cellmediated anti tumor activity. Pulmonary Valve Implantation using Selfexpanding Tissue Valve without Cardiopulmonary Bypass: a Controlled Randomised Trial Intracellular mechanisms of resistance to somatostatin and dopamine receptor agonists in neuroendocrine tumors Hybrid revascularisation by combined CABG and PCI in multivessel coronary disease: clinical outcomes and optimal management. An observational study. Lombardia CLI ORD Oncology 2 13 450.000 Lombardia CLI ORD Digestive, Kidney 13 450.000 and Urological Systems HUMANITAS ORD Immunology 13 452.000 MAGGIORE CLI EST Surgical, Biomedical Imaging, and Bioengineering 13 460.000 MAGGIORE CLI ORD Oncology 2 13 470.000 SAN RAFFAELE PISANA CLI ORD Cardiovascular and 13 477.700 Respiratory 2306109 In vivo modeling glioblastoma to identify new therapeutic targets and assay a novel oncolytic therapy IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 13 480.000 2316250 NMR spectroscopy for metabolism based classification of glioblastoma derived stem cells Istituto Superiore di Sanita' ORD Oncology 2 13 490.000 Pagina 162 di 332

2317696 Repeated influenza A infections as a risk factor for the development of Parkinson s disease during aging SAN RAFFAELE PISANA ORD Infectious Diseases 13 500.000 and Microbiology 2321301 Semicarbazide sensitive amine oxidases (SSAOs) and matrix degrading metalloproteases (MMPs): a multidisciplinary study of their possible contribution to cerebral amyloid angiopathy (CAA) in Alzheimer's disease. SAN RAFFAELE PISANA CLI ORD Brain Disorders and 13 500.000 2320768 2314429 2309550 LOGICAL BANK TO IDENTIFY MARKERS OF DISEASE ACTIVITY RELATED TO CLINICAL VARIABLES AND MODIFYING DRUGS IN MULTIPLE SCLEROSIS CLINICAL IMPACT OF CIRCULATING TUMOR CELLS AND MOLECULAR MARKERS IN THE DIAGNOSIS AND FOLLOW UP OF SOLID TUMORS The link between inflammation, synaptic alterations and neurodegeneration in experimental and human multiple sclerosis Emilia Romagna CLI ORD Brain Disorders and 13 500.000 Toscana CLI ORD Oncology 2 13 500.000 SANTA LUCIA CLI ORD Brain Disorders and 13 500.000 2312635 Comparative effectiveness: Hospital volumes and outcomes of treatments. Systematic reviews and observational study in the Italian NHS Agenzia per i Servizi Sanitari Regionali CLI ORD Healthcare Delivery 13 500.000 and Methodologies 2316373 2308819 Biomaterial functionalization to improve biofunctionality and osteointegration of medical devices for healthy and osteopenic bone. Analysis of macrophage and neutrophil subpopulations in the vascular remodelling occurring in HCC genesis and progression. Implications for early diagnosis, prognosis and therapy. RIZZOLI ORD Musculoskeletal, 13 504.000 Oral and Skin HUMANITAS ORD Oncology 2 13 508.000 Pagina 163 di 332

2311513 2307814 2308208 2314292 2311289 2316216 2309396 Experimental models for investigation of interrelationship between CSCs/TICs and metastasis A New Nonsurgical Treatment for Type 2 Diabetes in Obese Patients: Endobarrier versus Intragastric Balloon. A Prospective Randomized Trial and biological studies on the increased thyroid cancer incidence in the volcanic area of Sicily. Role of host pathogen interplay in genital cancer pathogenesis: gene mutations and nucleotide polymorphisms as determinants of cancer susceptibility and response to therapy A novel in vivo model to study molecular determinants in lymphopoietic disorders Molecular bases of phenotypic heterogeneity of Alzheimer's disease: diagnostic and therapeutic implications Explaining coronary heart disease mortality trend in Italy between 2000 and 2010 and forecasting health and economic scenarios for prevention strategies Emilia Romagna ORD Oncology 1 Basic 13 510.000 Sicilia CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 13 515.000 Sicilia CLI ORD Oncology 2 13 515.000 PASCALE ORD Oncology 1 Basic 13 517.000 C.R.O. AVIANO EST Oncology 1 Basic 13 538.800 CARLO BESTA EST Brain Disorders and 13 540.000 Istituto Superiore di Sanita' ORD Population 13 542.300 and Epidemiology 2317530 The use of Nanoparticles in food technology: release assessment and development of analytical methods through selected case studies Istituto Zooprofilattico Sperimentale delle Venezie ORD Bioengineering 13 546.700 and Technologies 2308519 COMBINATORIAL IMMUNOLOGICAL AND NANOPARTICLE MEDIATED TARGETING OF THE EARLY STEPS OF THE METASTATIC DISEASE C.R.O. AVIANO ORD Oncology 1 Basic 13 547.000 Pagina 164 di 332

2314226 2318733 MOLECULAR AND FUNCTIONAL PROFILES OF NON SELF SUFFICIENCY ELDERLY:FROM DIAGNOSIS TO CARE MODELS Predictive value of heart rate viariability in fetuses of high risk pregnancies. Development of a new method for accurate and rapid signal detection and analysis. Calabria CLI ORD Healthcare Delivery 13 550.000 and Methodologies Friuli Venezia Giulia CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 13 570.000 2310943 NAD dependent signaling as a target in cerebrovascular disease: a preclinical assessment in mouse disease models IRCCS AOU San Martino IST (Genova) EST Brain Disorders and 13 585.000 2318542 2313085 2312974 2312336 IMmunity, Inflammation and Carotid ATherosclerosis: the IMICAT study NANOSTRUCTURED SCAFFOLD TO ENHANCE NERVE REGENERATION Development of innovative immunotherapeutic strategies against oligomeric beta amyloid isoforms by intracellular antibody technology Multi Structured Data Analysis for Patient Specific Human Ligaments Modelling MONZINO ORD Vascular and 13 585.200 Hematology Toscana ORD Bioengineering 13 590.000 and Technologies SAN RAFFAELE PISANA ORD Brain Disorders and 13 590.000 RIZZOLI ORD Surgical, Biomedical Imaging, and Bioengineering 13 594.000 2317233 Whole ovary or isolated oocyte controlled exposure to environmental contaminants and radiation sources in farm animals Impact on animal production and translational research for human reproductive medicine Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata ORD Endocrinology, Metabolism, Nutrition and Reproductive 13 594.000 Pagina 165 di 332

2313385 2304708 2320124 2321755 2317111 MODULATION OF POST TRANSLATIONAL MODIFICATIONS AND QUALITY CONTROL SYSTEMS AS A NOVEL THERAPEUTIC STRATEGY FOR PROTEIN MISFOLDING DISEASES Non cancer (atherosclerotic, neurocognitive, reproductive) health effects of chronic low dose radiation exposure in cardiac catheterization lab workers (the Healthy Cath Lab Study) Chemical protection against ionizing radiation in subjects undergoing radiodiagnostic procedures: analysis of the role of natural compounds in a translational research plan CIRCULATING ANTI TRANSGLUTAMINASE ANTIBODIES: A NOVEL MARKER OF RECURRENT ABORTION AND A KEY INFLUENCER OF NEO ANGIOGENESIS Circulating Tumour Cells (CTC) and Cancer Stem Cells from human prostate: new device and tools for markers detection,cell isolation and their ex vivo expansion as three dimensional structures GASLINI ORD Genes, Genomes 13 595.000 and Genetics Sicilia CLI ORD Cardiovascular and 13 595.000 Respiratory Istituto Superiore di Sanita' ORD Risk, Prevention 13 599.800 and Health Behavior Molise ORD Cell Biology 13 600.000 Lazio ORD Digestive, Kidney 13 600.000 and Urological Systems 2319903 CLINICAL AND INSTRUMENTAL EVALUATION OF A LOCAL INTRAOPERATIVE DRUG THERAPY TO IMPROVE PRIMARY STABILITY IN TOTAL KNEE REPLACEMENT RIZZOLI ORD Musculoskeletal, 13 600.000 Oral and Skin 2320782 Emerging contaminants in the feed food chain: integrated models to support risk analysis Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary 13 600.000 Pagina 166 di 332

2321819 Custom made devices for bone regenerative medicine. RIZZOLI ORD Musculoskeletal, 13 600.000 Oral and Skin 2316513 Exploring hierarchical immunogenicity of mismatched HLA haplotypes for the design of innovative functional matching algorithms in allogeneic transplantation SAN RAFFAELE MONTE TABOR ORD Immunology 13 600.000 2315847 2321979 2312594 A perspective study in HIV infected individuals to determine the impact of HAART and the role of specific antiviral immune responses on the establishment and maintenance of virus reservoirs, which are key for chronic virus persistence and disease progress Daily at home follow up of Parkinson s Disease patients motor performance through robotic and portable devices TENDINOPATHY FROM PATHOPHYSIOLOGY TO TREATMENT: HOW TO TARGET REGENERATIVE MEDICINE. SAN GALLICANO ORD AIDS and Related 13 600.000 Research SAN RAFFAELE PISANA EST Brain Disorders and 13 600.000 RIZZOLI CLI ORD Musculoskeletal, 13 600.000 Oral and Skin 2318456 Papillomavirus (HPV) genital infection in men: genotypes prevalence, presence of viral transcripts and association with genital clinical signs and sperm function Sicilia ORD Endocrinology, Metabolism, Nutrition and Reproductive 13,17 293.000 2311080 Study of new factors associated with pathogenicity in V. parahaemolyticus and nono1 nono139 V. cholerae and multilocus sequence typing approach for epidemiological surveillance Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary 13,25 188.000 2311213 The KidsInPlaces Initiative: an international partnership for the study of societal resilience and early child development Emilia Romagna CLI EST Population 13,25 220.000 and Epidemiology Pagina 167 di 332

2315805 2320975 2307044 EARLY EVENTS IN THE INDIRECT PATHWAY IN ANIMAL MODELS OF PARKINSON S DISEASE. Characterization of melanoma cells from primary and metastatic human melanoma in culture: prognostic and therapeutic implications Role of calcineurin/nuclear Factor Activated in T cells (NFAT) activation in leukemogenesis NEUROMED EST Brain Disorders and 13,25 290.000 Emilia Romagna ORD Oncology 1 Basic 13,25 300.000 I. O. V. ORD Oncology 1 Basic 13,25 407.000 2313731 Investigating the role of heterochromatin destabilization and Rif1 in the Italian breast cancer population REGINA ELENA ORD Oncology 1 Basic 13,25 499.949 2318337 In vivo imaging of microglia signature: from mouse models to brain injured patients MAGGIORE EST Molecular, Cellular, 13,25 529.000 and Developmental 2318109 Innovative tools to predict the response to chemotherapy in cancer patients SAN RAFFAELE MONTE TABOR ORD Oncology 1 Basic 13,33 450.000 2318023 PLERIXAFOR ADMINISTRATION AND MOBILIZATION OF ENDOTHELIAL PROGENITOR CELLS TO PROMOTE NEO VASCULARIZATION IN PATIENTS WITH CRITICAL LIMB ISCHEMIA SAN RAFFAELE MONTE TABOR CLI ORD Cardiovascular and 13,34 600.000 Respiratory 2315001 2314277 Endostatin in chronic urticaria: a mediator involved in the pathogenesis, a tool for the diagnosis and follow up and a potential target for therapy Immunotherapy with CIK Cells for the treatment of mesenchymal tumors: preclinical activity and synergism with targeted therapies Toscana ORD Immunology 13,5 105.000 Piemonte ORD Oncology 2 13,5 125.000 Pagina 168 di 332

2322068 2306123 2305130 2320120 Assessment and longitudinal monitoring of thymic output and immune status in the 22q11.2 deletion syndrome Biological markers in bone metastases from prostate cancer: evaluation of live and apoptotic Circulating (CTC) and Disseminated tumor cells (DTC) in patients undergoing chemotherapy and correlation with tumor response and bone turnover rate. Patient participation in Change of Shift Procedures. The Implementation of the Bedside handover for the improvement of nursing quality Impact of screening on survival in breast cancer patients: the role of tumor biology Toscana ORD Immunology 13,5 130.000 I. O. V. CLI ORD Oncology 2 13,5 150.000 ARCISPEDALE CLI ORD Healthcare Delivery 13,5 154.927 and Methodologies Toscana ORD Population 13,5 155.400 and Epidemiology 2321815 Optic nerve and retinal ischemia: the long pentraxin PTX3 as a marker to discriminate vasculitic and non vasculitic causes of sudden blindness SAN RAFFAELE MONTE TABOR CLI ORD Musculoskeletal, 13,5 165.000 Oral and Skin 2312208 2321305 NEW MARKERS FOR THE EVALUATION OF SPERM DNA STATUS IN ONCOLOGICAL PATIENTS. RESPIRATORY TRAINING IN HEART FAILURE: A NON INVASIVE METHOD TO INCREASE THE CHOLINERGIC ANTI INFLAMMATORY PATHWAY Piemonte ORD Endocrinology, Metabolism, Nutrition and Reproductive 13,5 205.000 MAUGERI ORD Cardiovascular and 13,5 206.000 Respiratory 2319175 DEVELOPMENT OF AN INTEGRATED STATISTICS AND INFORMATICS FRAMEWORK FOR CLINICAL TRANSLATION AND EVALUATION OF NEW MARKER TECHNOLOGIES ISTITUTO TUMORI MILANO EST Oncology 2 13,5 212.000 Pagina 169 di 332

2313199 2321988 2320987 ROLE OF MATERNAL INTRAPARTUM ANTITIC PROPHYLAXIS ON NEONATAL GUT MICROTA FLORA AND ONSET OF LATER ALLERGY RELATED DISEASES. Proteomic salivary analysis and a mathematical model for diagnosis and classification of rheumatoid arthritis and early rheumatoid arthritis. Metabolomic analysis of primary immunodeficiency and its application to a lowcost neonatal screening program. Lombardia CLI ORD Infectious Diseases 13,5 220.000 and Microbiology Toscana ORD Musculoskeletal, 13,5 230.000 Oral and Skin Toscana ORD Immunology 13,5 242.000 2320504 Endocannabinoid receptors as potential target for novel therapeutic approaches in the treatment of bladder cancer SAN RAFFAELE MONTE TABOR ORD Oncology 2 13,5 250.000 2317978 Glucocorticoid receptor polymorphisms and Corticosteroid Binding Globulin polymorphisms may modulate the clinical effects of immunosuppressive therapy with corticosteroids in determining the risk of developing diabetes after kidney transplantation. Marche CLI EST Endocrinology, Metabolism, Nutrition and Reproductive 13,5 250.000 2312633 Evaluation of chemotherapy induced liver damage in patients with colorectal liver metastasis using of non invasive tools REGINA ELENA CLI EST Digestive, Kidney 13,5 250.000 and Urological Systems 2320800 2320725 Optimization, on the basis of Monte Carlo dosimetry, of the therapeutical effectiveness and toxicity of Peptide Radio Receptor Therapies in patients with neuroendocrine tumours THE ROLE OF ALCOHOL USE IN PATIENTS WITH A FIRST EPILEPTIC SEIZURE IN DIFFERENT POPULATIONS. Sicilia CLI ORD Oncology 2 13,5 250.000 Piemonte CLI ORD Population 13,5 250.000 and Epidemiology Pagina 170 di 332

2305084 2308189 2304751 2306519 2316561 2312696 2312849 2319035 2320965 MECHANISMS REGULATING DENDRITIC CELL PROTUMORAL ACTIVITY WITHIN THE HYPOXIC MICROENVIRONMENT: POTENTIAL THERAPEUTIC APPLICATIONS IN NEUROBLASTOMA Long term effects of chronic metal ion exposure in patients with orthopaedic implants: biochemical and molecular investigation PREVENTION AND DIAGNOSIS OF FETAL ALCOHOL SYNDROME (FAS) AND FETAL ALCOHOL SPECTRUM DISORDER (FASD) Restoring synaptic degeneration and memory through manipulations of caspase 3/calcineurin activity in mice modelling Alzheimer Disease. SURVIVE: ChemokineS as new therapeutic drugs for cell Viability and functional recovery in brain ischemia. Antiplatelet aspirin therapy and megakaryocytic gene expression: molecular and cellular mechanisms underlying "drug resistance" in preventing cardiovascular events. Unlocking tumor immune recognition through self HLA E molecules Metal ions levels in symptomatic and asymptomatic patients with metal on metal replacement Improvement of ALS patients communication by means of a Brain Computer Interface system based on ERP single trial detection Liguria ORD Oncology 1 Basic 13,5 260.000 RIZZOLI ORD Risk, Prevention 13,5 275.000 and Health Behavior Istituto Superiore di Sanita' CLI ORD Biobehavioral and 13,5 280.000 Behavioral Processes SANTA LUCIA ORD Molecular, Cellular, 13,5 296.200 and Developmental SAN RAFFAELE PISANA ORD Molecular, Cellular, 13,5 300.000 and Developmental Istituto Superiore di Sanita' ORD Vascular and 13,5 300.000 Hematology REGINA ELENA EST Immunology 13,5 300.000 Lombardia CLI ORD Risk, Prevention 13,5 300.000 and Health Behavior S.CAMILLO CLI ORD Emerging Technologies and Training in s 13,5 301.500 Pagina 171 di 332

2303136 2303866 2319078 2307834 2317098 2309078 2318916 2316052 2302872 EVALUATION OF EFFICACY AND SAFETY OF FLAVOCOXID, A CATECHIN AND BAICALIN FLAVONOIDS ASSOCIATION, IN THE MANAGEMENT OF METABOLIC SYNDROME: A PRECLINICAL AND CLINICAL STUDY DEFINING THE PATHOLOGICAL IMPLICATIONS OF IGF I AND/OR DHT ABUSE IN HEALTHY SUBJECTS Integration of high throughput and analytical data to discover biomarkers of cell products quality and therapy efficacy in dendritic cells based cancer immunotherapy studies Priority setting in healthcare: the case of home care program in Tuscany Region for heart failure patients Targeting 14 3 3 protein to develop novel antiparasitic drugs: the Giardia model Vg9Vd2 T cells in combination with zoledronate as novel immunotherapeutic approach for human neuroblastoma Comparative efficiency and risk assessment of grafting human gabaergic neural precursors from different sources in experimental models of Huntington disease. Adult Niemann Pick type C disease as a model of tauopathy. Implications for the pathogenesis of Alzheimer disease. GENETIC AND NEUROLOGICAL INFLUENCES ON RISK TAKING PROPENSITY Sicilia ORD Endocrinology, Metabolism, Nutrition and Reproductive 13,5 350.000 SDN ORD Endocrinology, Metabolism, Nutrition and Reproductive 13,5 350.000 Istituto Superiore di Sanita' EST Oncology 2 13,5 350.000 Toscana CLI ORD Healthcare Delivery 13,5 350.000 and Methodologies Istituto Superiore di Sanita' ORD Infectious Diseases 13,5 367.000 and Microbiology GASLINI ORD Oncology 2 13,5 367.200 SAN MATTEO ORD Brain Disorders and 13,5 370.000 CARLO BESTA ORD Brain Disorders and 13,5 385.000 Istituto Superiore di Sanita' ORD Population 13,5 389.100 and Epidemiology Pagina 172 di 332

2317801 Role of the mitogen activated protein kinase ERK5 in chronic liver injury and hepatocellular carcinoma Toscana ORD Digestive, Kidney 13,5 400.000 and Urological Systems 2309932 Prediction of cognitive impairment in Parkinson s disease: genetic, biochemical and functional neuroimaging study CASA SOLLIEVO SOFFERENZA ORD Brain Disorders and 13,5 400.000 2310855 2315191 2320728 2311149 2311704 2311357 2317999 Physiological and Pathological contribute of L cysteine/hydrogen sulphide pathway in controlling the function of rat and human bladder Exposure assessment and early effect evaluation in subjects exposed to incidental nanoparticles during working activities in the mechanical engineering factory The UbcH10 therapeutic selection value in the tyrosine kinase inhibitor therapy for the NSCLC THE EFFECTIVENESS OF STRUCTURED PSYCHOEDUCATION FOR RELAPSE PREVENTION IN BIPOLAR DISORDERS A translational study to identify and validate predictive molecular and cytogenetic biomarkers of durable complete response to trastuzumabcontaining chemotherapy for HER2 positive metastatic or locally advanced breast cancer Pathogenesis of idiopathic thromboembolism: role of anti endothelial auto antibodies and endothelial cell dysfunctions. The role of Integrin alpha5/beta1 as a potential therapeutic target in bone metastasis: a translational study NEUROLESI ORD Digestive, Kidney 13,5 400.000 and Urological Systems Lazio ORD Bioengineering 13,5 400.000 and Technologies CROB ORD Oncology 2 13,5 400.000 FATEBENEFRATELLI CLI ORD Biobehavioral and 13,5 400.000 Behavioral Processes HUMANITAS ORD Oncology 2 13,5 432.400 HUMANITAS ORD Immunology 13,5 433.000 I. O. V. ORD Oncology 2 13,5 450.000 Pagina 173 di 332

2318108 2319264 2314199 ANTIOXIDANT TREATMENT TO PREVENT MEDICAL HAZARDS OF CYCLIC VARIATIONS OF SOLAR ACTIVITY Integration of expression profiles and genetic mapping data to identify risk variants in IgA nephropathy Multidisciplinary study of the motor function in obese subjects with Prader Willi syndrome: from molecular control to muscular performance. SAN DONATO COF Endocrinology, Metabolism, Nutrition and Reproductive 13,5 450.000 Puglia EST Digestive, Kidney 13,5 450.000 and Urological Systems AUXOLOGICO CLI ORD Musculoskeletal, 13,5 450.000 Oral and Skin 2321299 Health Technology assessment on mesenchymal stem cells and growth factors in orthopedics and traumatology Agenzia per i Servizi Sanitari Regionali CLI ORD Healthcare Delivery 13,5 450.000 and Methodologies 2317858 2321614 The Pathogenic Role of Trem 2 in Inflammatory Bowel Disease: Implication for Novel Therapeutic Analysis of the clinical heterogeneity on a wide cohort of Rett patient through a biochemical and molecular approach HUMANITAS ORD Digestive, Kidney 13,5 453.000 and Urological Systems AUXOLOGICO ORD Genes, Genomes 13,5 455.000 and Genetics 2321396 Exploiting the crosstalk between epithelial cells and dendritic cells as a cause of the HIV 1 induced immune dysregulation in the gut. SAN RAFFAELE MONTE TABOR ORD AIDS and Related 13,5 456.720 Research 2310924 2314710 Alteration of B cell compartment in acute and chronic HIV 1 infected individuals: implication for vaccinations Salivary lipidomic and oxidative profile in response to dietary intervention for the oral cancer risk reduction. Lombardia ORD AIDS and Related 13,5 460.000 Research Marche ORD Oncology 2 13,5 480.000 Pagina 174 di 332

2319397 2319010 2321961 2315106 2308180 2312774 2316881 2321934 Human bone cage for lumbar spine interbody fusion: biomechanical evaluation. Functional, ultrastructural and molecular changes in skeletal muscle in chronic heart failure: new insights for a therapy against cardiac cachexia Metabolic syndrome and liver cancer: surveillance program on large population in Veneto Study of a method of calculation of the optimum radionuclide activity in radioimmunotherapy of tumors based on the reduction of the target mass Diurnal and Inter visit IOP fluctuations: a risk factor for conversion from ocular hypertension to primary open angle glaucoma? GENetics of familial and sporadic Lone Atrial Fibrillation (GenLAF) Plasmonic nanostructures and microfluidic devices: light concentration and manipulation towards quantitative biosensing Pharmacoepidemiology, pharmacosurveillance and identification of predictive factors of oxaliplatin neurotoxicity in colorectal cancer: development and validation of a prognostic score Emilia Romagna ORD Bioengineering 13,5 500.000 and Technologies SAN RAFFAELE PISANA ORD Musculoskeletal, 13,5 500.000 Oral and Skin Veneto CLI ORD Risk, Prevention 13,5 500.000 and Health Behavior Veneto ORD Oncology 2 13,5 501.000 FATEBENEFRATELLI CLI ORD Risk, Prevention 13,5 508.889 and Health Behavior SAN MATTEO CLI ORD Genes, Genomes 13,5 510.000 and Genetics Calabria ORD Bioengineering 13,5 540.000 and Technologies Toscana ORD Oncology 2 13,5 548.900 2308268 Spinal Cord Modular Organization in Recovery and Back to Work Management of Neurological Patients. Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro ORD Integrative, Functional, and Cognitive 13,5 584.000 2315305 Inhibition of cathepsin B as a potential therapeutic strategy for human melanoma: in vitro and in vivo investigations Istituto Superiore di Sanita' ORD Oncology 1 Basic 13,5 586.000 Pagina 175 di 332

2313115 2321217 Analysis of immune reconstitution following a new protocol of haploidentical bone marrow transplantation with low incidence of infections Identification and validation of co morbidity scores and analysis of their impact on the fitness for treatment in patients with solid and haematological tumours HUMANITAS ORD Immunology 13,5 589.000 HUMANITAS CLI ORD Healthcare Delivery 13,5 590.000 and Methodologies 2306509 Animal breeding and functional food to improve human health. Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 13,5 600.000 2315311 2316560 Study of the implication of peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC 1a) and adipose triglygeride lipase (ATGL) in Parkinson s disease PTPRJ and EGFR as targets for innovative molecular therapies of lung cancer SAN RAFFAELE PISANA ORD Molecular, Cellular, 13,5 600.000 and Developmental Calabria ORD Oncology 2 13,5 600.000 2305826 Pathogenic mechanisms and animal models of hereditary neurodegenerative cerebellar diseases due to mitochondrial defects. Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Genes, Genomes 13,5 600.000 and Genetics 2317273 2315344 The genetic basis of mental retardation: modeling Williams Beuren syndrome through somatic cell reprogramming Predictive value of early PET/CT with 18FDG PET on standard dimensional tumor assessment in patients with advanced/metastatic cancer receiving treatment with target based agents. I.E.O. ORD Brain Disorders and 13,5 600.000 PASCALE CLI ORD Oncology 2 13,5 600.000 Pagina 176 di 332

2317080 2319147 2311163 2319227 2319163 2320890 2317718 2321608 impact of accurate patient specific threedimensional treatment planning in molecular radiotherapy Identification and characterization of new SHOXrelated and SHOX unrelated mutations by Next Generation Sequencing analysis and pharmacogenomics evaluation of rhgh treatment Fertility preservation in young Oncological female patients Early risk indicators and prevention of dementia following stroke. Dietary patterns in midlife and occurrence of Alzheimer disease in old ages A novel approach to hand motor, language and interaction rehabilitation in autism spectrum disorders. Evaluation of Neuroprotection with NGF Mimetic Compounds Using Molecular Microimaging of Apoptotic Post ischemic Neuronal Death Long term Legionella control in hospital hotwater distribution systems by water treatment with natural terpenoid based products: assessment of their antimicrobial and toxicological activities in batch, pilot plant and real scale conditions. ARCISPEDALE EST Oncology 2 13,5 600.000 Emilia Romagna CLI ORD Genes, Genomes 13,5 600.000 and Genetics REGINA ELENA CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 13,5 600.000 S.CAMILLO CLI EST Brain Disorders and 13,5 600.000 Lombardia CLI ORD Population 13,75 229.000 and Epidemiology MEDEA CLI ORD Biobehavioral and 13,75 295.900 Behavioral Processes Toscana ORD Brain Disorders and 13,75 360.000 Istituto Superiore di Sanita' CLI ORD Infectious Diseases 13,75 516.000 and Microbiology Pagina 177 di 332

2310982 The neurobiology of social behaviour: physiological and pathological processes in mice and humans Istituto Superiore di Sanita' EST Biobehavioral and 13,75 526.000 Behavioral Processes 2319246 Mitochondrial dysfunction in ALS : a study of novel molecular partners as targets for therapeutic interventions Emilia Romagna ORD Molecular, Cellular, 13,84 600.000 and Developmental 2316567 Policystic ovary syndrome and nitric oxide. Effects of the treatment with N acetylcysteine Piemonte CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 14 0 2308290 Understanding and treating impairment in automatic movements execution in Parkinson's disease IRCCS AOU San Martino IST (Genova) CLI EST Integrative, Functional, and Cognitive 14 150.000 2320634 High detection of chronic kidney disease (CKD) in general population by combination of estimated glomerular filtration rate (GFR) and microalbuminuria Puglia CLI ORD Digestive, Kidney 14 150.000 and Urological Systems 2319700 Advance care planning for continuous sedation Toscana CLI ORD Oncology 2 14 150.000 until death in the Hospice setting. What is its role? 2299760 Sensitizing cancer stem cells driven glioma to radiotherapy via pharmacological inhibition of Ataxia Telangiectasia Mutated protein IRCCS AOU San Martino IST (Genova) ORD Oncology 2 14 152.000 2314478 2317964 Non invasive cerebral PET data quantification with aortic image derived input function governance and occupational well being: a new organizational approach to healthcare performance Toscana CLI ORD Healthcare Delivery and Methodologies 14 155.000 Emilia Romagna CLI ORD Healthcare Delivery 14 170.000 and Methodologies Pagina 178 di 332

2314546 2307159 2312026 2317224 2316858 2318660 HIV patient s adherence: a study of predictive factors VENOUS THROMBOEMBOLISM IN FAMILIES WITH INHERITED THROMBOPHILIA: STRATIFICATION OF THE RISK IN THE CARRIER RELATIVES ACCORDING TO THE CLINICAL PHENOTYPE OF THE PROBAND. IMPLICATIONS FOR FAMILIAL LABORATORY INVESTIGATION OF INDIVIDUALS WITH INHERITED THROM Screening for Autoimmune Polyglandular Syndrome Type 2 in patients with autoimmune thyroiditis: definition of methodology and costbenefit analysis. soluble EGFR in the biotherapeutical approach of colorectal cancer Effects of repetitive transcranial magnetic stimulation after early stroke: a study in children and developing rats NIR Laser Therapy in pediatric hematooncological patients with oral mucositis induced by chemotherapy: evaluation of clinical efficacy and correlation with modifications of oral microbiota and immunogenic properties of pathogenic microrganisms. Lombardia CLI ORD AIDS and Related 14 185.000 Research Lazio CLI ORD Population 14 187.000 and Epidemiology Toscana CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 14 195.000 ARCISPEDALE ORD Oncology 2 14 200.000 STELLA MARIS CLI ORD Brain Disorders and 14 200.000 Toscana CLI ORD Infectious Diseases 14 200.000 and Microbiology 2317154 BiS trial: randomized controlled trial on biologic vs synthetic mesh for the treatment of large defect congenital diaphragmatic hernia. OSPEDALE BAMBINO GESU' CLI ORD Surgical, Biomedical Imaging, and Bioengineering 14 200.000 Pagina 179 di 332

2316212 The molecular interaction between dystroglycan and glycosyltransferases and how it is related to the clinical severity of primary and secondary dystroglycanopathies OSPEDALE BAMBINO GESU' ORD Musculoskeletal, 14 209.000 Oral and Skin 2319988 2308314 2309497 2321877 2302921 2321960 2321780 CLINICAL AND ADMINISTRATIVE WORKLOAD: PHYSICIANS WELLBEING, PERFORMANCE AND CONSEQUENCES ON PATIENT SAFETY. COMPARATIVE ANALYSIS AMONG FIVE IMPORTANT ACUTE HOSPITALS CHARACTERIZATION OF NEW MOLECULAR MARKERS OF NEUROINFLAMMATION ASSOCIATED WITH ALZHEIMER'S DISEASE Stem and progenitor cell therapy for the treatment and prevention of bronchopulmonary dysplasia in preterm infants: pre clinical in vitro studies Studies on the cardiovascular effects of mandibular stretching and on their potential application in the treatment of arterial hypertension RELEASE OF MICRO VESICLES DURING MYOGENIC DIFFERENTIATION PROCESS Identification of new genes responsible for Albinism phenotype Ovarian serous carcinoma:identification of prognostic and predictive markers and risk assessment. Toscana CLI ORD Risk, Prevention 14 210.000 and Health Behavior Sicilia ORD Molecular, Cellular, 14 213.000 and Developmental SAN MATTEO ORD Cardiovascular and 14 215.000 Respiratory Toscana CLI ORD Cardiovascular and 14 218.233 Respiratory S.CAMILLO ORD Cell Biology 14 220.000 Lombardia EST Genes, Genomes 14 220.000 and Genetics Calabria ORD Oncology 1 Basic 14 225.000 Pagina 180 di 332

2320238 2314862 2322074 2320234 2315241 2313610 2310006 2321666 Whole exome sequencing of schizophrenia patients with large Copy Number Variations or Run of Homozigosity and functional study of CSMD3, a gene found deleted in a schizophrenia patient. Whole exome sequencing to identify causative genes in Caudal Regression Syndrome Phenotype characterisation of Arrhythmogenic Right Ventricular Cardiomyopathies (ARVC) caused by mutations of desmosome and nondesmosome genes Effectiveness of multidisciplinary clinical approach and psychological treatment on enhanced recovery after surgery in patients with Inflammatory Bowel Diseases (IBD) Quality assurance and improvement of MRI and PET analysis on imaging biomarkers processed in grid environments through automated machine learning approaches. Identification of specific metabolic pathways and protein networks involved in myocardial and cerebral dysfunction and preservation following resuscitation from cardiac arrest and discovery of new biomarkers predictive of functional outcome. Angiogenesis and cell nutrition in lumbar degenerative disc disease: a numerical and experimental investigation Transciptome of B lymphocytes in Multiple Sclerosis. FATEBENEFRATELLI ORD Genes, Genomes 14 230.000 and Genetics GASLINI CLI ORD Genes, Genomes 14 234.520 and Genetics SAN MATTEO CLI ORD Cardiovascular and 14 235.000 Respiratory Toscana CLI ORD Risk, Prevention 14 240.000 and Health Behavior FATEBENEFRATELLI ORD Healthcare Delivery 14 249.000 and Methodologies SAN DONATO ORD Cardiovascular and 14 250.000 Respiratory GALEAZZI ORD Bioengineering 14 250.000 and Technologies SANTA LUCIA ORD Brain Disorders and 14 250.000 Pagina 181 di 332

2306440 2315514 2310476 2305075 Improving quality of research: a complex intervention trial "Web based national registry of pediatric collections of specimens and health, environmental, lifestyle data intended to research purposes" Isoform selective histone deacetylase inhibitors in experimental models of ALS: molecular and therapeutic effects The effectiveness of music therapy on depression and on Quality of Life in patients with Amyotrophic Lateral Sclerosis and in post Stroke condition. Emilia Romagna CLI ORD Healthcare Delivery 14 250.555 and Methodologies MEDEA ORD Genes, Genomes 14 253.000 and Genetics Toscana ORD Brain Disorders and 14 255.000 MAUGERI CLI ORD Healthcare Delivery 14 262.800 and Methodologies 2318437 Identification of novel targets in thyroid carcinogenesis by sirna based loss of function screening ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 14 270.050 2321247 2319558 2304457 2314410 Long term efficacy of non pharmacological computer assisted treatment in Alzheimer s Disease and MCI (Mild Cognitive Impairment) patient Randomized Trial Of Cytoreductive Surgery And Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy In Peritoneal Carcinomatosis Arising From Colorectal Cancer A therapeutic approach to Fragile X syndrome based on the pharmacology of Rho GTPases IDENTIFICATION OF NEW GENETIC, PROTEIC AND METABOLIC MARKERS TO DISTINGUISH BENIGN FROM MALIGNANT THYROID CELLS. Lombardia CLI ORD Brain Disorders and 14 275.000 ARCISPEDALE CLI ORD Oncology 2 14 280.650 Istituto Superiore di Sanita' ORD Brain Disorders and 14 283.768 Toscana ORD Genes, Genomes 14 300.000 and Genetics Pagina 182 di 332

2320654 2309890 Investigation of biochemical and molecular mechanisms underlying photoaging process by a lipidomic approach Identification of new genetic determinants of inhibitor development in patients with hemophilia A by exome sequencing SAN GALLICANO ORD Musculoskeletal, 14 300.000 Oral and Skin MAGGIORE ORD Genes, Genomes 14 300.000 and Genetics 2319477 Multicenter Randomized Phase III Study Comparing the combination of 5 Fluorouracil plus Folinic Acid, Irinotecan and Oxaliplatin (FOLFIRINOX) versus Gemcitabine as Adjuvant Treatment for Resected Pancreatic Cancer Toscana CLI ORD Oncology 2 14 300.000 2321533 Epidemiological, clinical and molecular aspects of Environmental Intolerance Disorders with difficult diagnosis: Implications for Disease Definition, Diagnosis, and Treatment. ISTITUTO DERMOPATICO DELL'IMMACOLATA CLI ORD Population 14 300.000 and Epidemiology 2317892 Integrated management of continuity of care for amyotrophic lateral sclerosis: proposal for a model Lombardia CLI ORD Healthcare Delivery 14 300.000 and Methodologies 2303796 PREGNANCIES IN WOMEN WITH PREVIOUS ADVERSE OBSTETRIC EVENTS AND PREGNANCY RELATED VENOUS THROMBOEMBOLISM : NEW DIAGNOSTIC TOOLS AND IMPROVEMENT OF THERAPEUTHIC STRATEGIES CASA SOLLIEVO SOFFERENZA EST Endocrinology, Metabolism, Nutrition and Reproductive 14 300.000 2320637 Anaplastic lymphoma kinase (ALK) gene status assessment to improve treatment of pulmonary sarcomatoid carcinoma, a therapeutically challenging subtype of lung cancer ISTITUTO TUMORI MILANO CLI ORD Oncology 2 14 301.400 Pagina 183 di 332

2312460 2315377 2321837 2306673 2304699 2318024 2317730 2312951 2313075 IDENTIFICATION OF EARLY NEUROCOGNITIVE MARKERS OF DEVELOPMENTAL DYSLEXIA: THE ROLE OF RAPID AUDITORY PROCESSING AND ITS RELATIONSHIP WITH FOLLOWING PHONOLOGICAL DEFICITS Combined molecular and functional studies to identify novel targets for neuroprotection against brain and spinal cord damage: from bench to bedside. PET imaging of TSPO in neurodegenerative diseases and tumors. MicroRNA Signature of Vascular Complications in Type 1 Diabetes Innate immune signaling networks in intestinal epithelial cells and their role in shaping T cell responses in inflammatory bowel diseases Circulating microrna as potential biomarkers of prediabetic and diabetic complications LCAT MODULATION TO TREAT ATHEROSCLEROTIC CARDIOVASCULAR DISEASE Tuberculosis control among immigrants in Italy: a cost effectiveness assessment. Synaptic alteration of mglur signaling underlying SHANK3 mutations in intellectual disability and their rescue by pharmacological therapies MEDEA ORD Brain Disorders and 14 325.000 Toscana ORD Brain Disorders and 14 326.000 ONCOLOGICO DI BARI CLI ORD Surgical, Biomedical Imaging, and Bioengineering 14 340.000 Piemonte ORD Cardiovascular and 14 350.000 Respiratory Istituto Superiore di Sanita' ORD Immunology 14 350.000 Veneto ORD Cardiovascular and 14 350.000 Respiratory Lombardia EST Vascular and 14 350.000 Hematology Piemonte CLI EST Infectious Diseases 14 360.000 and Microbiology CARLO BESTA EST Molecular, Cellular, 14 360.000 and Developmental Pagina 184 di 332

2312416 2319121 2319414 2311359 Development of cytochrome c assay marker of ischemia/reperfusion damage to the heart PREDICTION OF AWAKENING FROM ACUTE COMA USING THE BRAIN REACTIVITY TO PAIN RELATED SOMATOSENSORY EVOKED POTENTIALS AND PAIN RELATED FUNCTIONAL BRAIN MAGNETIC RESONANCE. CLINICAL AND MOLECULAR ANALYSIS OF IPEX LIKE SYNDROMES: FOXP3 gene INDEPENDENT DEFECTS OF PERIPHERAL TOLERANCE. Transposon based Forward Genetic Screen for the Identification of non coding RNAs involved in Colorectal Cancer Metastasis I.E.O. ORD Cardiovascular and 14 365.000 Respiratory Veneto CLI ORD Brain Disorders and 14 377.700 Toscana ORD Immunology 14 383.000 C.R.O. AVIANO ORD Oncology 1 Basic 14 386.100 2314432 CDKL5 variant of Rett s syndrome: clinical phenotype and effects of mutations on the development of the central nervous system in view of future therapeutic approaches Istituto Scienze Neurologiche ORD Brain Disorders and 14 396.756 2319250 2319364 2315697 Enhancing Transparency of Reporting of Systematic Reviews to Improve Health Care Integrating chromatin structure, transcriptional regulation and gene expression as a novel approach to define the role of iron regulatory proteins and to study the effect of immunomodulatory and hypomethylating agents on iron genes in experimental models USE OF NEXT GENERATION SEQUENCING IN CLINICS: EVALUATION OF MODELS OF EARLY OR COMPREHENSIVE DIAGNOSIS IN A REGIONAL ASSET Emilia Romagna ORD Healthcare Delivery and Methodologies 14 399.000 Piemonte ORD Oncology 1 Basic 14 400.000 Liguria CLI ORD Genes, Genomes 14 400.000 and Genetics Pagina 185 di 332

2320364 Molecular modeling and functional analyses of EGFR for the selection of lung cancer patients eligible for targeted therapy with receptor kinase inhibitors ISTITUTO TUMORI MILANO ORD Oncology 2 14 400.400 2315126 Modulation of mir 221 and mir 222 in skeletal muscle cells: impact on muscle physiology and pathology Istituto Superiore di Sanita' ORD Musculoskeletal, 14 412.200 Oral and Skin 2314940 Studies of the pathogenic mechanisms and zoonotic role of Porcine Circovirus type 2 (PCV2) and Torque Teno virus (TTV) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary 14 414.000 2317293 2316966 Homing and fate of adipose derived stem cells in two animal models of stroke Development and progression of breast cancer: when EMT meets stemness AUXOLOGICO ORD Biology of 14 416.000 Development and Aging C.R.O. AVIANO ORD Oncology 1 Basic 14 417.000 2308055 Analysis of the effect of chemotherapeutic treatment on trastuzumab cytotoxic activity ISTITUTO TUMORI MILANO ORD Oncology 2 14 429.000 2312077 2322042 2306418 New biomolecular markers (HJURP, HIF 1 alpha, TG2), to predict response to radiotherapy in patients with carcinoma in situ of the breast. Trans abdominal RObots for Minimally Invasive Surgery (TROMIS) Gender and age related differences in motility and permeability responses in human colon: role of estrogens. Emilia Romagna ORD Oncology 2 14 435.000 Lombardia ORD Surgical, Biomedical Imaging, and Bioengineering 14 440.000 DE BELLIS ORD Digestive, Kidney 14 440.000 and Urological Systems Pagina 186 di 332

2319401 2313483 2306549 2306441 2314595 2317581 Multisensory modulation of body representations as a proxy to reduce phantom limb pain in amputees: behavioural, cognitive and neurophysiological studies. Investigations on the pathophysiological role of pendrin, an ion exchanger expressed in thyroid, innear ear and kidney: novel perspectives for the diagnosis and treatment of patients with pendrinrelated disorders. Molecular determinants of tumour resistance to radio/chemotherapies Monitoring allogeneic Hematopoietic stem cells transplant patients for viral load and CMV drug resistance genotypes The mevalonate (Mev) pathway as a common metabolic target to modulate the susceptibility of Multiple Myeloma (MM) and Chronic Lymphocytic Leukemia (CLL) tumor cells to chemotherapy, environmental prosurvival signals, and immune recognition by Vgamma9Vde Aberrant expression and/or function of the Calcium Sensing Receptor (CaSR) as mechanisms underlying ovarian cancer SANTA LUCIA ORD Integrative, Functional, and Cognitive 14 449.000 AUXOLOGICO ORD Genes, Genomes 14 450.000 and Genetics Veneto EST Oncology 2 14 450.000 GASLINI ORD Infectious Diseases 14 475.000 and Microbiology Piemonte ORD Oncology 2 14 483.000 ONCOLOGICO DI BARI ORD Oncology 1 Basic 14 498.000 2315037 Post Transplant Hematopoiesis: a model to understand the mechanisms of hematopoietic stem cells (HSC) aging and the interactions between HSC and micro environment. IRCCS AOU San Martino IST (Genova) ORD Vascular and 14 500.000 Hematology 2318595 Promoting neuroplasticity for the symptomatic treatment of patients with Multiple Sclerosis SANTA LUCIA ORD Brain Disorders and 14 500.000 Pagina 187 di 332

2316587 How to improve and rationalize targeted head and neck squamous cell carcinoma treatments ISTITUTO TUMORI MILANO ORD Oncology 2 14 500.005 2315663 Personalising curative treatment decision for locally advanced head and neck cancer through identification of biological markers ISTITUTO TUMORI MILANO ORD Oncology 2 14 500.600 2321816 2321024 2312076 2317681 Integrated approach to investigate the effect of environmental pollution on reproductive outcomes AN ALTERNATIVE APPROACH TO CLINICAL MANAGEMENT OF GESTATIONAL DIABETES Evaluation of AIFA monitored antineoplastic drugs in advanced cancer patients in the last months of life in Regione Emilia Romagna Brain complexity and complexity matching for enhancing the positive effects of environmental enrichment on psychopathology Emilia Romagna ORD Genes, Genomes 14 525.000 and Genetics Lombardia CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 14 535.100 Emilia Romagna CLI ORD Healthcare Delivery 14 540.000 and Methodologies Istituto Superiore di Sanita' CLI ORD Integrative, Functional, and Cognitive 14 545.000 2317410 Glia immune crosstalk in multiple sclerosis SAN RAFFAELE MONTE TABOR ORD Molecular, Cellular, 14 550.000 and Developmental 2320102 Analysis of immunological reconstitution after intrabone cord blood transplantation for hematological malignancies OSPEDALE BAMBINO GESU' ORD Immunology 14 550.000 2305169 Autism Epilepsy: endophenotypic characterization and correlation with astrocyteneuron interaction defects. STELLA MARIS ORD Biobehavioral and 14 557.150 Behavioral Processes Pagina 188 di 332

2316283 Opportunistic virus infections in transplant recipients and patients with chronic inflammatory diseases treated with biological immunosuppressive drugs SAN MATTEO ORD Immunology 14 570.000 2320335 2316288 2319221 2310965 Identification of slow proliferating cancer cells with stem like features Genetic and epigenetic mechanisms in addiction: An opportunity for development of new pharmacotherapeutic strategies for alcoholism. Early detection of brain metastases: in vivo advanced MRI markers in breast and lung cancer patients. New treatments for alleviation of neuropathy and regenerative impairment in diabetes. Istituto Superiore di Sanita' EST Oncology 1 Basic 14 570.000 FATEBENEFRATELLI ORD Brain Disorders and 14 570.500 SAN RAFFAELE PISANA CLI ORD Brain Disorders and 14 585.600 MULTIMEDICA ORD Cardiovascular and 14 585.942 Respiratory 2315899 Vaccine platform for oncogenic viruses. PASCALE EST Immunology 14 587.500 2316983 2314049 2318152 2314316 Development of bispecific antibodies for therapeutic approaches against HIV infection. Hormonal implications in the mesothelioma pathogenesis. Radiation effects of low and/or protracted doses: from the mechanisms underlying the biological effects to the impact on public health Antiprotons vs photons: a new hypothesis for radiotherapy Istituto Superiore di Sanita' ORD AIDS and Related 14 592.717 Research REGINA ELENA EST Oncology 1 Basic 14 596.500 Istituto Superiore di Sanita' ORD Oncology 2 14 599.500 ONCOLOGICO DI BARI ORD Oncology 2 14 600.000 Pagina 189 di 332

2322015 STUDIES OF NEOPLASTIC PREVALENCE IN SINATHROPUS ANIMALS LIVING ON NATIONAL INTEREST SITES(SIN)IN CAMPANIA REGION AND EPIDEMIOLOGICAL RESEARCH ON ENVIRONMENTAL ONCOLOGICAL RISKS Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 14 600.000 2315454 2311106 2307112 2320541 2318020 Genetic analysis of TPH2 in patients with Major Depression as a predictor of SSRI responsiveness. Role of glucocorticoid induced leucine zipper (GILZ) in autoimmunity NEW PURINERGIC STRATEGIES TO IMPLEMENT ENDOGENOUS NEUROGENESIS AND RE MYELINATION IN THE REPAIR OF SPINAL CORD INJURY AND BRAIN ISCHEMIA. Dissection of the interplay between Ku70/86 and APAF1 as a novel regulatory mechanism in brain tumours The interplay between glutamatergic intracellular pathways and dopamine neurotransmission: relevance for novel antipsychotic strategies and in antipsychotic refractory conditions. FATEBENEFRATELLI ORD Brain Disorders and 14 600.000 Istituto Superiore di Sanita' ORD Immunology 14 600.000 NEUROLESI ORD Molecular, Cellular, 14 600.000 and Developmental SANTA LUCIA ORD Cell Biology 14 600.000 PASCALE ORD Emerging Technologies and Training in s 14 600.000 2317900 Role of endocannabinoids in multiple sclerosis SANTA LUCIA ORD Brain Disorders and 14 600.000 2320796 Mechanisms of altered DNA methylation in sporadic and hereditary colorectal cancer REGINA ELENA EST Genes, Genomes 14 600.000 and Genetics 2314055 Innovative therapeutic approaches against CD49ddriven microenvironmental interactions in chronic lymphocytic leukemia C.R.O. AVIANO EST Oncology 1 Basic 14 600.000 Pagina 190 di 332

2313065 2320258 2311234 2319954 2314793 2303803 2307559 2308714 2314240 New minimally invasive arthroscopical approach for the treatment and prevention of hip osteoarthritis THERapeutically relevant STEM cells for THALassemia (THERSTEMTHAL) Using hyperbaric hyperoxigenated transportable machine to preserve liver to be transplanted.a new preservation method evaluated throught an animal model transplantation study. Long term cancer survivors: a comparison between treatments and disease free persons and persons with active disease under therapeutic control. Response Evaluation Criteria in Solid Tumors: a comparative study between Imaging and Biomolecular indices Fighting Alzheimer: new prospectives and therapeutical strategies Epigenetic profiles of prognostic markers and therapeutic targets in non small cell lung cancer Complex Interventions at Work: comparative analysis of case studies on implementation of process oriented organization of hospital care in community and teaching hospitals Enpowering neuromodulation by individually tuned brain behavior frequency RIZZOLI CLI ORD Surgical, Biomedical Imaging, and Bioengineering 14 600.000 Emilia Romagna EST Genes, Genomes 14 600.000 and Genetics Emilia Romagna EST Surgical, Biomedical Imaging, and Bioengineering 14 600.000 C.R.O. AVIANO CLI ORD Oncology 2 14 600.000 Sicilia CLI ORD Oncology 2 14 600.000 SANTA LUCIA EST Brain Disorders and 14 644.800 Emilia Romagna ORD Oncology 1 Basic 14,17 260.000 Emilia Romagna CLI ORD Healthcare Delivery 14,17 600.000 and Methodologies Istituto Superiore di Sanita' EST Emerging Technologies and Training in s 14,25 230.000 Pagina 191 di 332

2321252 Gio why not? A perspective observational study to improve early diagnosis of andrologic pathologies in young people. SAN RAFFAELE MONTE TABOR CLI ORD Risk, Prevention 14,25 375.000 and Health Behavior 2313416 Characterization of bone marrow endothelial cells in patients with chronic myeloproliferative diseases: towards anti angiogenic therapy CROB ORD Oncology 1 Basic 14,25 400.000 2312562 Molecular characterization of the Apical Membrane Antigen 1 from Italian strains of Babesia bigemina and study of its role in the protective host immune response. Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary 14,25 500.000 2315216 2319418 2318322 2312945 2321459 HYPOPLASTIC LEFT HEART SYNDROME (HLHS): FROM DISCOVERY OF GENETIC BASIS TO MOLECULAR CLASSIFICATION FOR THERAPEUTIC STRATEGIES Pancreatic Islet Cell Transplantation for Treatment of Type 1 Diabetes Electroclinical and genetic characterization of Epilepsy in a population of patients with ring 20 chromosome syndrome. EEG fmri study and comparison with a group of patients with frontal lobe epilepsies (genetic and structural etiologies) Improving surgical treatment of traumatic nerve injuries by artificial nerve guides: a benefit for the patient and the community HIV infected mesenchimal stem cell differentiation: mirna expression profile and role of antiretroviral therapy. Lombardia ORD Genes, Genomes 14,25 600.000 and Genetics ONCOLOGICO DI BARI ORD Endocrinology, Metabolism, Nutrition and Reproductive 14,3 600.000 Lombardia CLI ORD Brain Disorders and 14,5 75.000 Lazio CLI ORD Surgical, Biomedical Imaging, and Bioengineering 14,5 100.000 Lombardia CLI ORD AIDS and Related 14,5 125.000 Research Pagina 192 di 332

2320065 2304028 2321527 2316775 Identification of new molecular targets in preclinical models of cholangiocarcinoma and in tumor derived xenopatients What is better for the therapy of chronic inflammatory demyelinating polyneuropathy? Intravenous Immunoglobulins versus steroids and intravenous immunoglobulins versus sub cutaneous immunoglobulins: a nationwide costutility study. Effect of telemedicine on Haemophilia Management, Treatment Effectiveness and Patient's Quality of Life Individual and social effects of a sensitisation campaign on headache Piemonte ORD Oncology 2 14,5 150.000 Piemonte CLI ORD Brain Disorders and 14,5 150.000 Abruzzo CLI COF Healthcare Delivery 14,5 150.000 and Methodologies Lazio CLI ORD Healthcare Delivery 14,5 150.000 and Methodologies 2311019 UNMET NEEDS, QUALITY OF LIFE AND FAMILY BURDEN AMONG ICHTHYOSIS PATIENTS ISTITUTO DERMOPATICO DELL'IMMACOLATA CLI ORD Healthcare Delivery 14,5 159.000 and Methodologies 2318781 2318060 Developing new sensitive and objective outcome measures in muscle disorders: the promising role of muscle fat fraction and mapping. Involvement of mutant p53 gain of function in tumor microenvironment NEUROLESI CLI ORD Musculoskeletal, 14,5 163.000 Oral and Skin REGINA ELENA ORD Oncology 1 Basic 14,5 180.000 2319393 Identification of predictive markers of response to Therapeutic Plasma Exchange in Multiple Sclerosis Lazio ORD Vascular and 14,5 180.000 Hematology 2312593 Influence of metabolic factors on inflammation of colorectal mucosa in colorectal cancer risk assessment Emilia Romagna ORD Oncology 2 14,5 185.500 Pagina 193 di 332

2318506 Role of home pulse oxymetry in management of patients with idiopathic pulmonary fibrosis: a prospective, multicenter study Emilia Romagna CLI ORD Cardiovascular and 14,5 195.000 Respiratory 2321617 Heart failure specialist nurse services (HFSN) Marche CLI ORD Healthcare Delivery 14,5 200.000 and Methodologies 2321868 2321009 2315854 2312121 2312471 THERAPEUTIC DEVICE OF AREA FOR ADOLESCENCE WITH SEVERE PSYCHIATRIC DISORDERS. PROSPECTIVE STUDY ON EFFICACY. Aortic dimensions and properties in normal population and hypertensive patients: focus on thoracic aortic dilatation The anatomical substrate of unilateral neglect subtypes A NEW STRATEGY FOR A HIGH PREVALENCE CONDITION: ORTHOSTATIC HYPOTENSION. WHAT S UP IN REHABILITATION SETTING? Neurobiological bases of the Impulse Control Disorders: the role of the cerebellum. Lombardia CLI ORD Risk, Prevention 14,5 200.000 and Health Behavior Piemonte CLI ORD Cardiovascular and 14,5 201.000 Respiratory S.CAMILLO ORD Brain Disorders and 14,5 224.400 MAUGERI CLI ORD Risk, Prevention 14,5 227.000 and Health Behavior SANTA LUCIA CLI EST Brain Disorders and 14,5 230.000 2309943 Molecular screening and identification of the causative role of Protocadherin 19 (PCDH19) gene (Xq22) gene in a spectrum of epilepsy phenotypes and genotype phenotype correlation. OSPEDALE BAMBINO GESU' ORD Genes, Genomes 14,5 231.000 and Genetics 2309590 Peri operative stress in cardiac surgery: psychosocial aspects, genetic predisposition and biohumoral characterization Toscana CLI ORD Cardiovascular and 14,5 244.000 Respiratory Pagina 194 di 332

2308754 Development of optical diagnostic tools for inflammatory bowel diseases based on Raman light scattering. BURLO GAROFALO CLI ORD Surgical, Biomedical Imaging, and Bioengineering 14,5 245.600 2317764 DEVELOPMENT OF A METHOD FOR NON INVASIVE ROUTINE PRENATAL DIAGNOSIS OF MONOGENIC DISORDERS USING CELL FREE DNA IN MATERNAL PLASMA Veneto ORD Genes, Genomes 14,5 250.000 and Genetics 2318085 Ring annuloplasty versus Suture repair for the treatment of Not Severe Tricuspid Regurgitation in patients undergoing surgery for Mitral Valve disease: a Prospective, Randomized Study. SAN RAFFAELE MONTE TABOR CLI ORD Surgical, Biomedical Imaging, and Bioengineering 14,5 250.000 2313417 2319176 2308500 2319850 2309321 Multi(bio)marker characterization of COPD in the elderly: diagnostic, clinical and prognostic implications Physical exercise and cognitive stimulation: an innovative strategy to contrasting dementia. Epidemiology of primary biliary cirrhosis in Lombardia: a validation and geographical clustering study PREDICTIVE FACTORS IN NSCLC TREATMENT WITH GEFITINIB: ROLE OF TUMOR MICROENVIRONMENT Sensorimotor Integration. Physiology and Pathophysiology SANTA LUCIA ORD Cardiovascular and 14,5 260.700 Respiratory Piemonte CLI ORD Risk, Prevention 14,5 267.000 and Health Behavior HUMANITAS CLI ORD Population 14,5 272.500 and Epidemiology ONCOLOGICO DI BARI ORD Oncology 2 14,5 272.850 MAUGERI ORD Integrative, Functional, and Cognitive 14,5 279.860 Pagina 195 di 332

2320639 NEW THERAPEUTIC MODALITIES FOR GRAVES ORBITOPATHY WITH THE ANTI CD20 MONOCOLONAL ANTIBODY RITUXIMAB Lombardia CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 14,5 295.000 2299457 GENETIC MODULATION OF COELIAC DISEASE CASA SOLLIEVO SOFFERENZA ORD Digestive, Kidney 14,5 300.000 and Urological Systems 2321297 The role of anti C terminal ADAMTS13 antibodies in acquired thrombotic thrombocytopenic purpura MAGGIORE ORD Vascular and 14,5 300.000 Hematology 2315918 Sleepiness related accident risk in sleep disorders with excessive daytime sleepiness: from driving simulator performance to real road accident risk. Istituto Scienze Neurologiche ORD Emerging Technologies and Training in s 14,5 300.000 2315624 Novel assays for the diagnosis of scleroderma Marche ORD Immunology 14,5 300.000 2312640 2312592 Characterization of HIV related mechanisms involved in the development of Burkitt s lymphoma Studying Down Syndrome allows to early diagnose Alzheimer s disease Emilia Romagna ORD AIDS and Related 14,5 300.000 Research SANTA LUCIA CLI ORD Brain Disorders and 14,5 300.000 2319402 The effect of moderate aerobic activity (fitwalking) on the metabolic and cardiovascular complications induced by antiretroviral therapy in patients with HIV infection SAN RAFFAELE MONTE TABOR CLI ORD AIDS and Related 14,5 300.000 Research 2317342 Evaluation of neuroendocrine derangements after severe acquired brain injuries: influence on clinical progression and functional recovery during rehabilitation Emilia Romagna CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 14,5 300.000 Pagina 196 di 332

2321943 2317236 An integrated pharmacogenetic approach to the optimization of adjuvant hormonal treatment of estrogen receptor positive breast cancer Application of new PET tracers for early imaging of radiation induced lung fibrosis in a mouse model Toscana ORD Oncology 2 14,5 320.000 Toscana ORD Oncology 2 14,5 325.000 2316819 Identification and functional characterization of genes associated with metastatic risk in uveal melanomas with monosomy of chromosome 3 using integrated genomics IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 14,5 330.000 2306723 MZN, a new natural herbal compound to combat HIV infection SAN RAFFAELE MONTE TABOR ORD AIDS and Related 14,5 330.000 Research 2320891 Evaluation and modulation of behavioral and neurophysiological markers of alcohol misuse S.CAMILLO ORD Brain Disorders and 14,5 338.000 2317166 Udder and milk changes during mycoplasma mastitis in sheep: identification of humoral and cellular indicators for clinical/disease staging and vaccine efficacy Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary 14,5 340.000 2308166 2319679 2315800 Metabolic syndrome in the etiology and prognosis of hepatocellular carcinoma: a multicentre study. THE DOMOTIC GERIATRICS UNIT (DOMO_GER): AN INTELLIGENT SENSOR NETWORK FOR THE PREVENTION OF NEGATIVE OUTCOMES (DELIRIUM, FALLS, SUDDEN DEATH) IN HOSPITALIZED OLDER PATIENTS. EARLY ENVIRONMENTAL RISK FACTORS AND THE RISK OF DEVELOPING ANOREXIA NERVOSA PASCALE CLI ORD Oncology 2 14,5 340.000 Veneto ORD Bioengineering 14,5 350.000 and Technologies FATEBENEFRATELLI CLI EST Brain Disorders and 14,5 350.000 Pagina 197 di 332

2316446 2314660 2316594 2321714 2310186 New radiotherapic technologies(t): role of hypofractionated(h) Intensity Modulated Image Guided Radiotherapy in Locally Advanced Non Small Cell Lung cancer (Stage IIIA IIIB) Myocardial Toll like receptors in human myocarditis. DEVELOPMENT OF A MULTIFUNCTION PLATFORM FOR TELEREHABILITATION Titanium based third generation biomimetic scaffolds for bone tissue regeneration Effect of chemotherapy on ovarian reserve oocytes and role of p63 Emilia Romagna CLI ORD Oncology 2 14,5 350.000 SAN RAFFAELE PISANA CLI EST Cardiovascular and 14,5 363.000 Respiratory S.CAMILLO CLI ORD Healthcare Delivery 14,5 367.000 and Methodologies SAN MATTEO ORD Musculoskeletal, 14,5 400.000 Oral and Skin Lazio ORD Endocrinology, Metabolism, Nutrition and Reproductive 14,5 400.000 2314571 Effect of Human C Peptide on the Prevention of Diabetic Retinopathy and Nephropathy in a Rat Model of Type 2 Diabetes SAN RAFFAELE MONTE TABOR EST Endocrinology, Metabolism, Nutrition and Reproductive 14,5 400.000 2312125 2322047 Role of Notch in regulation of mesenchymal cells from adipose tissue of heart failure patients: consequences for cell therapy Possibility to calculate the 131I activity based on the desired thyroid mass reduction in the radionuclide therapy of Graves' disease MAUGERI EST Cardiovascular and 14,5 400.000 Respiratory Toscana CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 14,5 400.000 Pagina 198 di 332

2313309 2315991 2314566 2316850 2309494 2308814 2307790 Risk benefit assessment of cardiovascular drug use in elderly and very old patients affected by cardiovascular disease: a multicentre pharmacoepidemiological study Tailoring electrical parameters of subthalamic nucleus stimulation to treat behavioural symptoms in Parkinson s disease Biomolecular Markers Involved in the Development of Hepatitis Virus Infections Associated Lymphomas: A Multicentric Case Control Study Proximal vs distal approach in the upper limb rehabilitation in sub acute patients using robotic platforms: effects on the motor performance and functional recovery. ROLE OF INFLAMMATION/IMMUNITY IN ATHEROSCLEROSIS: ANALYSIS OF POTENTIAL NOVEL MORPHOLOGIC AND/OR CHEMICAL MARKERS OF PLAQUE PROGRESSION/STABILIZATION Multidisciplinary identification of prognostic markers and therapeutic intervention in patients with epilepsy and psychiatric disorders comorbidity. A translational study. Genome Remodeling in Luminal B and Ductal Triple Negative Breast Cancer Metastasis and Xenograft: Exome sequencing analysis for identification of driver pathways to overcome resistance Lazio CLI ORD Healthcare Delivery 14,5 400.000 and Methodologies MAGGIORE CLI EST Brain Disorders and 14,5 408.800 C.R.O. AVIANO ORD Oncology 2 14,5 410.000 SAN RAFFAELE PISANA CLI ORD Brain Disorders and 14,5 410.000 SAN RAFFAELE PISANA ORD Vascular and 14,5 420.000 Hematology OASI MARIA S.S. ORD Brain Disorders and 14,5 430.000 I.E.O. ORD Oncology 2 14,5 445.000 Pagina 199 di 332

2314024 Interactive mapping of pathways and targets in renal cancers ISTITUTO TUMORI MILANO CLI ORD Oncology 2 14,5 445.500 2319275 The redox basis of opioid tolerance: from molecular mechanism to innovative therapeutic approach for chronic pain management SAN RAFFAELE PISANA ORD Integrative, Functional, and Cognitive 14,5 450.000 2319419 µ BiG: Micro Bioreactor platform for the generation and dynamic control of concentration Gradients SAN RAFFAELE MONTE TABOR ORD Bioengineering 14,5 450.000 and Technologies 2314368 2315830 2306140 2314798 2303607 POTENTIAL ROLE OF INFLAMMASOME AS INTRACELLULAR MEDIATOR OF INFLAMMATORY MANIFESTATIONS IN GAUCHER DISEASE (GD) Integrating ehealth technologies for Patient and General Practitioner Empowerment The role of CLIC1 (Chloride channel 1) in the tumorigenicity of glioblastoma cancer stem cells Advanced personal and environmental teledosimetry system PROGNOSTIC, PREDICTIVE AND THERAPEUTIC IMPLICATIONS OF THE DNA "METHYLOME" IN HUMAN CUTANEOUS MELANOMA GASLINI ORD Immunology 14,5 470.000 Lazio CLI ORD Healthcare Delivery 14,5 470.000 and Methodologies I.E.O. ORD Oncology 1 Basic 14,5 472.000 Toscana ORD Surgical, Biomedical Imaging, and Bioengineering 14,5 480.000 C.R.O. AVIANO CLI ORD Oncology 2 14,5 480.000 2313415 Breast Cancer targeting through innovative drug delivery systems. IRCCS AOU San Martino IST (Genova) ORD Oncology 2 14,5 495.000 Pagina 200 di 332

2315969 Building an implantable engineered trachea using amniotic stem cells GASLINI ORD Surgical, Biomedical Imaging, and Bioengineering 14,5 500.000 2308628 Genotype Phenotype correlation in familial melanoma patients and multiple primary melanoma patients: Analysis of clinical, histologic, dermoscopic and reflectance confocal microscopy features of melanomas and melanocytic nevi associated with MC1R variants SAN GALLICANO ORD Oncology 2 14,5 500.000 2317532 2307217 2320384 2307471 2305398 2312530 ADIPOSE DERIVED STEM CELLS FOR TENDON REPAIR: THE INFLUENCE OF HYPOXIA ON CELL CULTURES Wilson disease: methionine metabolism and epigenetic regulation of gene expression Preclinical studies on TM9SF4, a novel potential biomarker associated with malignancy in patients with skin cancers Comparative analysis of molecular alterations in circulating tumor cells, primary tumors and metastatic lesions in NSCLC: predictivity of response to targeted therapy A multidisciplinary approach to study Frontotemporal lobar degeneration Wnt/b catenin signaling in melanoma: in vitro and in vivo investigations RIZZOLI ORD Musculoskeletal, 14,5 500.000 Oral and Skin Veneto EST Genes, Genomes 14,5 500.000 and Genetics Istituto Superiore di Sanita' EST Oncology 1 Basic 14,5 500.000 Emilia Romagna ORD Oncology 2 14,5 515.000 FATEBENEFRATELLI ORD Genes, Genomes 14,5 520.000 and Genetics SAN GALLICANO EST Oncology 1 Basic 14,5 520.000 2318130 Branched peptides as novel tumor targeting agents Toscana ORD Oncology 2 14,5 540.000 Pagina 201 di 332

2314427 2307035 2314960 Autoantibodies specific to ATP synthase in the pathogenesis of Alzheimer disease Randomized pilot phase II study of Lenalidomide as adjuvant therapy for prevention of Hepatocellular carcinoma (HCC) recurrence after radiofrequency thermal ablation (RFA): molecular and immunological prognostic biomarkers Nd:YAG laser ablation for mininvasive endoscopic treatment of pancreatic neoplastic lesions: from animal model to human application SAN RAFFAELE PISANA EST Brain Disorders and 14,5 540.000 Emilia Romagna ORD Oncology 2 14,5 550.000 Lazio ORD Surgical, Biomedical Imaging, and Bioengineering 14,5 556.650 2316386 Growth and oncolytic properties of Influenza A viruses in human pancreatic tumour cells and animal models Istituto Zooprofilattico Sperimentale delle Venezie ORD Infectious Diseases 14,5 560.000 and Microbiology 2314036 Oncolytic HSV vector strategy for the study of TRIM8 role in the pathogenesis of glioblastoma and therapy. CASA SOLLIEVO SOFFERENZA EST Oncology 1 Basic 14,5 571.000 2315751 2318582 2320093 2310115 From sarcoma genetics and genomics to novel diagnostic and therapeutic strategies: a deep sequencing approach Brain Computer Interface for rehabilitation in stroke and partial spinal cord injury Functional BRAIN CHIP INTEGRATOR (fbci): A pilot study to implement novel rehabilitation strategies through neurochips technology in patients with disorders of consciousness. Innovative Therapies for memory impairment in Alzheimer's Disease C.R.O. AVIANO ORD Oncology 1 Basic 14,5 580.000 FATEBENEFRATELLI ORD Emerging Technologies and Training in s 14,5 589.600 CARLO BESTA CLI ORD Brain Disorders and 14,5 589.720 FATEBENEFRATELLI ORD Brain Disorders and 14,5 594.000 Pagina 202 di 332

2318714 Exploring the role of the HIV integrase inhibitor Raltegravir as a treatment of Secondary Progressive Multiple Sclerosis. Istituto Superiore di Sanita' ORD Brain Disorders and 14,5 600.000 2306639 Immunological biomarkers predictive of successful direct acting antiviral (DAA) therapy in chronic hepatitis C virus (HCV) infection SAN MATTEO ORD Infectious Diseases 14,5 600.000 and Microbiology 2319956 2311819 2312729 Identification of novel biomarkers for Renal Cell Carcinoma early diagnosis by peptidome and exosome analysis Fast tuning of the immune response across the blood brain barrier by drug repurposing in a preclinical setting for translation into stroke therapy Neuropsychological, neuropshysiological and neuroimaging markers of progression in prodromal Alzheimer disease (AD): an interdisciplinary approach to the early detection of AD patients Puglia ORD Oncology 2 14,5 600.000 SANTA LUCIA CLI ORD Brain Disorders and 14,5 600.000 SAN RAFFAELE PISANA CLI ORD Biology of 14,5 600.000 Development and Aging 2310546 Nerve Growth Factor as a topical treatment for chronic Graft versus Host Disease with ocular involvement: preclinical and randomized, double masked, controlled Phase II study SAN RAFFAELE MONTE TABOR CLI ORD Brain Disorders and 14,5 600.000 2318381 2305170 Effects of Antidepressant Drugs on Autophagy pathway in neurons Assessment of strategies for identifying undiagnosed type 2 diabetes mellitus MONDINO EST Brain Disorders and 14,5 600.000 Veneto CLI ORD Population 14,5 600.000 and Epidemiology 2315965 Host biomarkers in exhalate breath condensate and other accessible body fluids for clinical and incipient tuberculosis detection SAN RAFFAELE MONTE TABOR EST Infectious Diseases 14,5 600.000 and Microbiology Pagina 203 di 332

2313681 Use of antisense oligonucleotides to PTPN22 gene variant conjugated to immuno liposomes as a novel therapeutic approach in type 1 diabetes and autoimmune polyendocrine syndrome type 3 variant OSPEDALE BAMBINO GESU' CLI EST Immunology 14,5 600.000 2318892 2310813 2317428 2312503 2312973 2318507 2313734 2309621 Mother delivered infant massage in preterm infants to promote neurodevelopment and bonding: effects on infant sleep and brain maturation Molecular epidemiology, Immunoproteomic and host parasite interaction of Echinococcus granulosus complex DEVELOPMENT OF VALIDATED INSTRUMENTS TO ASSESS SPINAL CORD INJURY (SCI) SUBJECTS. Mathematical modelling of mosquito borne diseases in Italy Surveillance of the circulation of rotaviruses in the infantile population of Sicily in view of the introduction of rotavirus vaccination. Mechanisms and treatment of Alzheimer disease: what can we learn from epilepsy? POST TRANSCRIPTIONAL REGULATION AND MITOCHONDRIAL LOCALIZATION OF BRCA1 IN HUMAN BREAST CANCER NEUROREHABILITATIVE PROGRAM FOR LIMB APRAXIA BY NEUROMODULATION OF LINGUISTIC VICARIOUS SKILLS STELLA MARIS CLI EST Brain Disorders and 14,75 115.000 Istituto Superiore di Sanita' ORD Infectious Diseases 14,75 282.000 and Microbiology SANTA LUCIA CLI EST Brain Disorders and 14,75 295.000 Istituto Superiore di Sanita' ORD Population 14,75 307.000 and Epidemiology Sicilia ORD Infectious Diseases 14,75 365.000 and Microbiology SAN RAFFAELE PISANA ORD Brain Disorders and 14,75 490.000 ONCOLOGICO DI BARI ORD Oncology 1 Basic 14,75 574.000 FATEBENEFRATELLI EST Integrative, Functional, and Cognitive 14,75 580.000 Pagina 204 di 332

2319562 Study of the interactions between noise and vibration exposure in view of the assessment of synergistic effect on the cochlea Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro EST Risk, Prevention 14,75 585.000 and Health Behavior 2321094 2308748 2315848 CT scan evaluation of vertebral body derotation in adolescent idiopathic scoliosis surgery Nerve ultrasound examination. The definition of the anatomical damage in nerve diseases: over a functional evaluation to design a diagnostictherapeutic flow chart for patients with neurotraumatic lesions. Randomized Controlled Trial of Ultrasound enhanced thrombolysis in acute anterior circulation stroke RIZZOLI CLI ORD Surgical, Biomedical Imaging, and Bioengineering 15 40.000 Lazio CLI ORD Brain Disorders and 15 60.000 ARCISPEDALE CLI ORD Brain Disorders and 15 100.000 2321352 IPER EXPRESSION OF INSULIN RECEPTOR IN BREAST CANCER: ROLE OF THE TRANSCRIPTION FACTORS AP 2α AND p53 Calabria ORD Oncology 1 Basic 15 150.000 2320972 2307812 2310090 Early detection of anthracycline induced cardiotoxicity (ACT) with Tissue Doppler Imaging Echocardiography in pediatric patients carrying SNPs predictive of ACT Sarcopenic obesity in hospitalized older persons: prevalence, associations with the geriatric syndrome of frailty, and effect on clinically relevant adverse health outcomes Use of Tranexamic acid in elective orthopaedic prosthetic surgery for preventing blood loss. Emilia Romagna ORD Oncology 2 15 150.000 Emilia Romagna CLI ORD Biology of 15 150.000 Development and Aging Veneto CLI ORD Surgical, Biomedical Imaging, and Bioengineering 15 150.000 Pagina 205 di 332

2317340 Incidence of Human Papillomavirus Infection in a North East Italian Population of Patients with Oropharyngeal Squamous Cell Cancer Treated with Intensity Modulated Radiation Therapy and Correlation with Treatment Outcome and Survival Veneto CLI ORD Oncology 2 15 150.000 2318433 The challenge of risk stratification in cardiac surgery: the ACEF PLUS to catch extreme conditions SAN DONATO CLI ORD Risk, Prevention 15 150.000 and Health Behavior 2311254 Comparison between patient centered versus standard psoriasis outpatients facilities for management of mild psoriasis patients ISTITUTO DERMOPATICO DELL'IMMACOLATA CLI ORD Healthcare Delivery 15 150.000 and Methodologies 2320137 2310382 2318325 2313431 2311473 COMPLEMENTARY AND ALTERNATIVE MEDICINE FOR THE TREATMENT OF CHRONIC PAIN: A PILOT STUDY Prevalence of risk factors for cardiovascular and non viral hepatic diseases: an epidemiological study in two Italian populations Prevention interventions for promoting the health of men who have sex with men (MSM) in Palermo area. ROLE OF COLECALCIPHEROL IN THE TREATMENT OF MILD COGNITIVE IMPAIRMENT. Immunohistochemical and mirna analysis of tumoral neoangiogenesis in small liver lesions: diagnostic and prognostic value of old and new markers. NEUROLESI CLI ORD Biobehavioral and 15 156.500 Behavioral Processes Istituto Superiore di Sanita' ORD Population 15 173.800 and Epidemiology Sicilia ORD Risk, Prevention 15 175.000 and Health Behavior Piemonte CLI ORD Brain Disorders and 15 180.000 Emilia Romagna CLI ORD Oncology 2 15 180.000 Pagina 206 di 332

2318876 2321025 Personalized and optimized Road Map of effective integration between intensive medical treatment and secondary liver surgery in liver limited metastatic colorectal cancer (MCRC) through biomolecular characterization. THYMIDYLATE SYNTHASE AND MAMMALIAN TARGET OF RAPAMYCIN PATHWAYS IN MALIGNANT PLEURAL MESOTHELIOMA: FROM MOLECULAR PREDICTORS OF RESPONSE TO CHEMOTHERAPY TO NOVEL MULTIMODAL THERAPEUTIC STRATEGY. Abruzzo ORD Oncology 2 15 200.000 Piemonte CLI ORD Oncology 2 15 203.500 2316395 Effects of metformin on glucose consumption in normal and in cancer cells in vitro and in vivo Potential interference with 18 fluoro deoxyglucose uptake in positron emission tomograpghy IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 15 207.000 2317496 2312725 2311564 Plasma factors, integrins and modulators of podocyte shape. A new window on focal segmental glomerulosclerosis and its treatment Telemonitoring in long term ventilator dependent patients: a multicenter randomized controlled study PROJECT BRIDGE: integrated plan for hospitals and local areas of long term case management for patients with acute cerebrovascular event, stratifed according to their frailty risk. GASLINI EST Digestive, Kidney 15 208.440 and Urological Systems Toscana CLI ORD Cardiovascular and 15 209.000 Respiratory Emilia Romagna CLI ORD Healthcare Delivery 15 210.072 and Methodologies 2308284 The welfare of the heavy pigs: critical points and practical solutions Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary 15 220.000 2316985 STUDY OF MDR1 REGULATION MECHANISMS TO REVERSE DRUG RESISTANCE IN OSTEOGENIC SARCOMA RIZZOLI ORD Oncology 1 Basic 15 222.200 Pagina 207 di 332

2316702 SELECTION OF CARDIAC RESYNCHRONIZATION THERAPY CANDIDATES ACCORDING TO SIMULTANEOUS DETERMINATION OF MECHANICAL DYSSYNCHRONY, SITE OF LATEST ACTIVATION AND MYOCARDIAL SCAR Emilia Romagna ORD Cardiovascular and 15 225.000 Respiratory 2312239 2321587 Controlled yeast for delivery of therapeutic agents to the human gut. implementation of Adaptive Radiotherapy (ART) head and neck cancer. Evaluation of ART IMRT potential in reducing xerostomia and dysphagia. NEUROLESI ORD Digestive, Kidney 15 230.000 and Urological Systems I. O. V. CLI ORD Oncology 2 15 235.000 2321846 The use of a numerical model of the cardiovascular system to personalize and optimize cardiac resynchronization therapy (CRT) Lazio ORD Cardiovascular and 15 240.000 Respiratory 2315532 2314877 2313107 2314252 EXTRACORPOREAL PHOTOCHEMOTHERAPY IN THE TREATMENT OF ERYTHRODERMIC CUTANEOUS T CELL LYMPHOMA: CLINICAL ACTIVITY, TOXICITIES, QUALITY OF LIFE IMPROVEMENT AND RESPONSE ASSOCIATED LOGICAL MARKERS Early onset anorexia nervosa: the role of hyperactivity as predictor of outcome Relationship between biomarkers, diastolic left ventricular recoil reserve measurement and ventricular arterial coupling to improve diagnosis and risk stratification in diastolic heart failure. Bio Molecular markers in the secondary prevention, diagnosis, prognosis and personalized therapy of hepatocellular carcinoma. Piemonte CLI ORD Oncology 2 15 240.000 STELLA MARIS CLI ORD Risk, Prevention 15 240.000 and Health Behavior Umbria CLI ORD Cardiovascular and 15 249.760 Respiratory Veneto ORD Oncology 2 15 250.000 Pagina 208 di 332

2311467 2320072 2313156 2321339 2311054 2319807 2304432 Long term immune monitoring of patients with psoriasis or psoriatic arthritis treated with drugs targeting key mediators of the immune response to identify key parameters of therapeutic efficacy and/or disease progression Role profiles and clinical competencies: a new approach for healthcare workforce Gaining new insights into the molecular mechanisms underlying the cholangiocarcinoma How to evaluate Efficacy In the framework of costeffectiveness analysis for Growth Hormone (rhgh) Therapy in paediatric patients with Growth Hormone deficiency Identification of biomarkers for an early diagnosis of periprosthetic osteolysis Evaluation of the role of CD 133+/CD44+ colorectal TICs in patterns of metastatization and possible subsequent their clinical investigation Calcium handling proteins common gene variants for the prediction of life threatening arrhythmias in ICD recipients with heart failure SAN GALLICANO ORD Immunology 15 250.000 Emilia Romagna CLI ORD Healthcare Delivery 15 250.000 and Methodologies REGINA ELENA EST Genes, Genomes 15 250.000 and Genetics Piemonte CLI ORD Healthcare Delivery 15 270.000 and Methodologies Piemonte ORD Musculoskeletal, 15 285.000 Oral and Skin ONCOLOGICO DI BARI ORD Oncology 2 15 298.900 NEUROMED COF Cardiovascular and 15 300.000 Respiratory 2312697 Impaired VitaminD metabolism in Rheumatoid Arthritis. Implication for disease pathogenesis and treatment. Piemonte CLI EST Musculoskeletal, 15 300.000 Oral and Skin 2318218 Diffusion Weighted Imaging (DWI) for the detection and monitoring of pulmonary inflammation: preliminary assessment and validation with molecular imaging. Veneto EST Surgical, Biomedical Imaging, and Bioengineering 15 300.000 Pagina 209 di 332

2310475 11C Choline PET/CT as Image Guide for radiotherapic treatment of prostate cancer recurrent lymphnodes SAN RAFFAELE MONTE TABOR CLI ORD Oncology 2 15 300.000 2319269 2301232 DIALECTICAL BEHAVIOR THERAPY (DBT) VS. HIGH QUALITY OUTPATIENT CARE FOR BORDERLINE PERSONALITY DISORDER. A PRAGMATIC RANDOMIZED TRIAL. Dissecting molecular bases of methylmalonic acidemia by proteomic analysis Emilia Romagna CLI EST Biobehavioral and 15 300.000 Behavioral Processes SDN ORD Endocrinology, Metabolism, Nutrition and Reproductive 15 305.000 2318613 Novel approaches to Chronic Lymphocytic Leukaemia treatment by targeting stromasupported malignant B cell survival, leukaemiaassociated angiogenesis and redox state IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 15 310.000 2316050 2316875 2318075 2317568 Transcranial Direct Current Stimulation as treatment in depressive illness: mechanism of action and efficacy Horizontal Epidemiology for Neurological Disorders Evaluation of heart toxicity induced by radiotherapy and chemotherapy for breast cancer Isolation and characterization of mesenchymal stem cells: therapeutic implications for cardiac disease MAGGIORE CLI EST Brain Disorders and 15 310.000 CARLO BESTA CLI ORD Population 15 320.920 and Epidemiology Toscana CLI ORD Oncology 2 15 325.000 Emilia Romagna ORD Cardiovascular and 15 327.777 Respiratory Pagina 210 di 332

2311792 Abscisic acid, a new endogenous modulator of insulin release and glucose uptake: pre clinical studies of its use to improve the clinical assessment and design novel therapies for diabetes mellitus. IRCCS AOU San Martino IST (Genova) ORD Endocrinology, Metabolism, Nutrition and Reproductive 15 337.000 2315598 2317208 2309265 2308883 Nanoparticles engineered with antibody derivatives or other molecules recognizing markers overexpressed in tumor cells: breast cancer targeting and biodistribution Identification of novel genes involved in hereditary colorectal polyposis Neuropsychological, immunogenetic and functional profiles in neurodevelopmental disorders The role of internal models in locomotor schemas and neurorehabilitation of children with cerebral palsy Lombardia ORD Bioengineering 15 344.000 and Technologies Emilia Romagna ORD Digestive, Kidney 15 350.000 and Urological Systems DON GNOCCHI ORD Integrative, Functional, and Cognitive 15 350.000 SANTA LUCIA EST Brain Disorders and 15 350.000 2316602 Role of FOXP3 in breast cancer metastatic process and possible therapeutic targeting ISTITUTO TUMORI MILANO EST Oncology 1 Basic 15 357.500 2317198 The role of the immunoregulatory enzymes IDO1 and IDO2 in leukemia development from myelodysplasia: a target for leukemia specific therapy. Emilia Romagna ORD Immunology 15 360.000 2321859 Role of Calpains in Melanoma Cell Biology Toscana ORD Oncology 1 Basic 15 360.000 2310396 Sagittal balance in degenerative pathologies: analysis of the radiological, biomechanical and biological aspects involved in the standing position of the spine, pelvis and limbs. HUMANITAS ORD Surgical, Biomedical Imaging, and Bioengineering 15 363.000 Pagina 211 di 332

2317973 2321134 Cerebrospinal fluid and serum biomarkers of brain damage in epilepsy Longitudinal, comprehensive, integrated study of outcome in patients with prolonged disorders of consciousness (DOC) NEUROLESI CLI EST Brain Disorders and 15 370.500 MAUGERI CLI ORD Brain Disorders and 15 380.000 2303749 p63 dependent RNA regulatory network in human p63 associated syndromes and cancer IRCCS AOU San Martino IST (Genova) ORD Oncology 1 Basic 15 389.927 2312022 2314288 Ensuring the safety of human stem cells: evaluation of genomic stability and metrological assessment of regenerative medicine products Study of the interaction between polyomavirus JC (JCV) and stem cells Piemonte ORD Genes, Genomes and Genetics 15 400.000 Toscana ORD Infectious Diseases 15 400.000 and Microbiology 2319706 Role of oncogene induced senescence in thyroid carcinogenesis ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 15 400.000 2309479 2318987 2319145 Risk assessment and safety procedures for MRI examination on patients with deep brain stimulators The VERY SHINING (Vessels, Endothelium and Risk in the next Years. Sodium Handling and INtake: INteractions with Genes) Study. Identification of predictive biomarkers of pegifnalpha induced depression and comprehension of the underlying mechanisms Istituto Superiore di Sanita' EST Surgical, Biomedical Imaging, and Bioengineering 15 400.000 Veneto CLI EST Cardiovascular and 15 400.000 Respiratory FATEBENEFRATELLI EST Brain Disorders and 15 400.000 2310904 Establishing the early profile of chronic renal allograft dysfunction with functional magnetic resonance and contrast enhanced ultrasound SAN RAFFAELE MONTE TABOR CLI ORD Surgical, Biomedical Imaging, and Bioengineering 15 400.000 Pagina 212 di 332

2318913 2316389 2319082 2318760 Improving visual abilities in low vision patients with noninvasive brain stimulation. LONGITUDINAL CHANGES IN MICROARCHITECTURE AND NEURONAL METABOLISM ASSOCIATED WITH PROPRIOCEPTIVE TRAINING TO AMELIORATE BALANCE IN MULTIPLE SCLEROSIS Ingestible device for the intragastric treatment of Helicobacter pylori infection The impact of the insulin/igf I pathway in bladder cancer invasion and metastasis FATEBENEFRATELLI ORD Emerging Technologies and Training in s 15 411.400 REGINA ELENA CLI EST Emerging Technologies and Training in s 15 415.000 Toscana ORD Infectious Diseases 15 420.000 and Microbiology Calabria EST Oncology 1 Basic 15 420.000 2299397 Development of new strategies to study alcoholism: evaluation of toxicity, tolerance and ethanol dependence mechanisms by molecular imaging, genetic and epigenetic analysis Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise EST Molecular, Cellular, 15 433.000 and Developmental 2320705 2315932 2315460 A translational approach to hypertrophic cardiomyopathy: new therapeutic targets for a personalized drug therapy Targeted resequencing of genomic regions by next generation sequencing technologies Study of the modifications of hematopoietic stem cells methylation profile after transplantation and their role in influencing transplant biology Toscana ORD Cardiovascular and Respiratory 15 450.000 GASLINI ORD Genes, Genomes 15 450.000 and Genetics CROB ORD Vascular and 15 450.000 Hematology 2316601 Unraveling the fingerprint of a new subset of human tolerogenic dendritic cells SAN RAFFAELE MONTE TABOR ORD Immunology 15 454.000 2316585 New perspectives in colorectal cancer for early diagnosis and therapy ONCOLOGICO DI BARI ORD Oncology 1 Basic 15 456.000 Pagina 213 di 332

2320747 2309328 2319776 Multiple Chronic Conditions Prevalence, Care Management, Implications for Quality, and Health Costs Novel strategies for tackling obesity epidemics by targeting the resting energy expenditure (EE) Creation of a Network for a high level care of patients surviving cardiac arrest in Milan.Implementation of tissue donation after death and development of a non heart beating donation program. Lombardia CLI ORD Healthcare Delivery 15 458.000 and Methodologies AUXOLOGICO CLI EST Endocrinology, Metabolism, Nutrition and Reproductive 15 460.000 Lombardia CLI ORD Healthcare Delivery 15 460.000 and Methodologies 2314967 Monitoring insect vectors of Leishmania in Sicily based on climatic/environmental observations, and definition of mathematical forecast models that can predict the presence of insect vectors depending on environmental conditions. Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary 15 468.855 2306037 2310052 Producing ips cells: a biobank service for translational genetic research Research of biomarkers in peripheral blood and tissue specimens for early diagnosis and prediction of therapy response in patients with colorectal cancer. Liguria ORD Genes, Genomes 15 477.000 and Genetics Emilia Romagna ORD Oncology 2 15 478.245 2316031 Title: Developing and Evaluation of innovative methods for detecting and trace infective pathogens in foods: molecular correlation with human cases Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary 15 490.000 2312123 TRANSMISSION OF SPORADIC CREUTZFELDT JAKOB DISEASE BY BLOOD: EPIDEMIOLOGICAL AND EXPERIMENTAL TRANSMISSION STUDIES Istituto Superiore di Sanita' ORD Population 15 500.000 and Epidemiology Pagina 214 di 332

2315211 2318199 2322008 COMBINED APPROACHES FOR DRUG DISCOVERY IN CONGENITAL CENTRAL HYPOVENTILATION SYNDROME Electro chemotherapy: improvement of local activitythrough new molecule association and tailored voltage delivery Association between Chronic Obstructive Pulmonary Disease and lung cancer: mechanisms of immune regulation GASLINI ORD Molecular, Cellular, 15 500.000 and Developmental I. O. V. ORD Oncology 2 15 500.000 Veneto ORD Cardiovascular and 15 500.000 Respiratory 2318768 Shaping the autoimmune response in the gut: the role of intestinal microbiota in immune regulation of Type 1 Diabetes SAN RAFFAELE MONTE TABOR EST Immunology 15 500.000 2312118 Molecular and genetic investigations of the role of BMP15 oocyte derived growth factor in female fertility AUXOLOGICO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 15 500.000 2317559 Development and exploitation of a platform able to produce antibody based reagents. From monoclonal murine antibody to completely human reagent using protein engineering to raise new potent diagnostic and therapeutic tools in oncology ISTITUTO TUMORI MILANO ORD Oncology 2 15 512.001 2313492 2320313 Role of Copy Number Variations in determining the individual susceptibility to essential hypertension NEW INSIGHTS FOR CAD PATIENT MANAGEMENT: in vivo assessment of coronary plaque morphology by means of OCT images and biohumoral markers (PLIMAB: PLaque IMAging Biomarkers) AUXOLOGICO ORD Cardiovascular and Respiratory 15 515.900 Toscana CLI ORD Cardiovascular and 15 516.666 Respiratory Pagina 215 di 332

2314737 Multimodal optical imaging platform for videorate intraoperative near infrared fluorescence cardiac imaging. Provincia autonoma Trento EST Surgical, Biomedical Imaging, and Bioengineering 15 520.000 2316193 Identification of mirna based Therapeutical Targets in Gliomas by Integrated Genomic Analyses. CASA SOLLIEVO SOFFERENZA ORD Oncology 1 Basic 15 550.000 2321795 2318985 2314017 2316186 Identification of Molecular and Genetic Fingerprints Characterizing T cell Non Hodgkin lymphoma Next generation approaches to identify novel pathophysiological mechanisms of coronary intrastent thrombosis and intra stent restenosis Exploitation of immunogenic tumor cell death for improved dendritic cell based cancer vaccines mirnas as New Potential Diagnostic and Predictive Biomarkers for Venous Thromboembolism in Cancer Patients: a Study MAGGIORE ORD Oncology 1 Basic 15 550.000 Toscana ORD Cardiovascular and 15 550.000 Respiratory C.R.O. AVIANO EST Oncology 2 15 550.000 Emilia Romagna ORD Vascular and 15 560.000 Hematology 2304875 Development, implementation and evaluation of a population based informational and educational package to improve knowledge on palliative care. A quasi experimental study in the Liguria Region. IRCCS AOU San Martino IST (Genova) CLI ORD Healthcare Delivery 15 560.000 and Methodologies 2318089 2320442 Molecular mechanisms involved in HIV related atherosclerosis: role of pathogen associated molecular patterns, type I interferons, and HIV replication. Viral respiratory tract infections in infants and young children: the IFNs/CD38/Ectonet axis as possible therapeutic target. MONZINO ORD Vascular and 15 561.000 Hematology Istituto Superiore di Sanita' ORD Immunology 15 569.800 Pagina 216 di 332

2318951 2314997 2321957 2303787 2312856 2319096 2313719 2311326 ADJUSTING THE ENVIRONMENTAL CONTEXT TO IMPROVE SEROTONINERGIC ANTIDEPRESSANT EFFICACY Identification of a panel of enteric hepatic biomarkers in children with an elevated risk of cardiovascular disease and type 2 diabetes A clinical strategy for cartilage repair and osteoarthritis treatment combining mesenchymal stem cell (MSC) based therapy with intrarticular hyaluronic acid infiltration ARTEMIS (Augmented Realism in Teleconsulting and Education in MinimallyInvasive Surgery) GENERATION OF PRION PROTEIN BASED COMPOUNDS AS NOVEL THERAPEUTIC STRATEGY FOR ALZHEIMER'S DISEASE strategy for developing rationale combinations of molecularly targeted agents in patients with non Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) Development of a carbon nanotube DNA biosensor for rapid detection of subgingival microbiota involved in periodontal diseases. Danger associated molecular patterns: revealing the molecular signals dictating the communication between dying cells with the immune system Istituto Superiore di Sanita' ORD Biobehavioral and 15 581.000 Behavioral Processes Toscana CLI EST Cardiovascular and 15 581.000 Respiratory Lazio CLI ORD Biology of 15 590.000 Development and Aging Toscana ORD Surgical, Biomedical Imaging, and Bioengineering 15 594.000 Lombardia EST Brain Disorders and 15 595.000 HUMANITAS ORD Oncology 2 15 600.000 Abruzzo ORD Infectious Diseases 15 600.000 and Microbiology Istituto Superiore di Sanita' ORD Oncology 2 15 600.000 Pagina 217 di 332

2314373 Metabolomics of Multiple Myeloma SAN RAFFAELE MONTE TABOR ORD Biological Chemistry and Macromolecular Biophysics 15 600.000 2320815 Exposure to low arsenic concentrations via drinking water and health effects in 91 municipalities of the Lazio region, Italy Lazio ORD Population 15 600.000 and Epidemiology 2314431 Innovative analytical procedures and rapid Istituto Zooprofilattico diagnostic methods for the assessment of hygienicsanitary status of the fishery and mariculture Mezzogiorno Sperimentale del production chains for the presence of emerging organic and inorganic micro pollutants and emerging zoonotic pathoge ORD Veterinary 15 600.000 2307684 Mechanisms of the antitumor activity of HIV protease inhibitors treatment in HIV negative patients affected by classical Kaposi s sarcoma or cervical intraepithelial neoplasia Istituto Superiore di Sanita' ORD Oncology 2 15 600.000 2318888 Pediatric brain tumors: evaluation of microrna signatures in cancer stem cells as disease markers in diagnosis, follow up and targeted therapy monitoring OSPEDALE BAMBINO GESU' ORD Oncology 2 15 600.000 2306323 2316350 SAFETY AND TOLERABILITY OF SECOND GENERATION ANTIPSYCHOTICS IN CHILDREN AND ADOLESCENTS: A PROACTIVE/PROSPECTIVE PHARMACHOVIGILANCE STUDY Induced pluripotent stem cell (ipsc) technology in the study of human genetic diseases of the hematologic system: modelling and correcting the cellular and genetic defect MEDEA CLI ORD Biobehavioral and 15 600.000 Behavioral Processes HUMANITAS EST Immunology 15 600.000 Pagina 218 di 332

2321034 RANDOMIZED CONTROLLED TRIAL OF MULTIDIMENSIONAL STIMULATION THERAPY IN PRODROMAL TO MODERATE STAGES OF ALZHEIMER'S DISEASE: CLINICAL, FUNCTIONAL MRI ASSESSMENT AND COST EFFECTIVENESS ANALYSIS. DON GNOCCHI CLI ORD Brain Disorders and 15 600.000 2309398 Early detection of lung cancer in asymptomatic high risk population by low dose CT scan and molecular markers. I.E.O. CLI ORD Oncology 2 15 600.000 2318954 Identification of new biomarkers in rhabdomyosarcoma: potential targets of novel therapeutic strategies. OSPEDALE BAMBINO GESU' EST Oncology 1 Basic 15 600.000 2319109 2319837 2318624 OVERCOMING TARGETED TREATMENT RESISTANCE IN HUMAN CANCER: NOVEL STRATEGIES TO INHIBIT SURVIVAL AND ESCAPE SIGNALS AND TARGETED DELIVERY OF ANTI CANCER NANOPARTICLES Gender specific oncology: psychoncology s contribution to global care and rehabilitation of young adult male and female patients Early signs and early treatment in Rett syndrome: a functional, imaging and molecular study in young patients and in MeCP2 null Mice. REGINA ELENA EST Oncology 2 15 600.000 C.R.O. AVIANO CLI ORD Oncology 2 15 730.000 STELLA MARIS ORD Brain Disorders and 15,25 260.000 2322016 Genome wide association study (GWAS) to identify new disease causing genes and new susceptibility loci for focal segmental glomerulosclerosis (FSGS) in European population. Puglia ORD Genes, Genomes 15,25 400.000 and Genetics Pagina 219 di 332

2314242 Biomolecular profiling of cutaneous squamous cell carcinoma and precursor lesions: HPV infection, immune system genes expression and polymorphism, mirna analysis and novel biomarkers investigation SAN GALLICANO ORD Oncology 1 Basic 15,25 495.000 2311225 Improving the diagnostic homogeneity in schizophrenia using cognitive endophenotypes: an integrated genetic, neuroimaging and neurocognitive approach SANTA LUCIA CLI EST Brain Disorders and 15,25 600.000 2312541 Functional and viability impairment of cardiomyocytes in familial amyloid polyneuropathy Toscana ORD Cardiovascular and 15,33 322.000 Respiratory 2319644 Genome wide SNP identification for high resolution molecular genotyping of Listeria monocytogenes Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata ORD Infectious Diseases 15,33 540.000 and Microbiology 2312852 2320345 2315777 2320607 2320228 PROMOZIONE DELLA SALUTE ORALE NELLE REALTA SCOLASTICHE DELLA ASL MILANO Calcium sensitizer agents for improving organs protection in transplants. Immune mechanisms of Food Protein Induced Enterocolitis Syndrome (FPIES) Pain management in patients with renal failure: conventional and unconventional pain therapy. A long term analysis of efficacy and tolerability of opioids analgesics and acupuncture in ESRD. HIV STDs coinfection in treated MSM patients: measurement of plasmatic and seminal HIV Viral Load Lombardia CLI ORD Healthcare Delivery 15,5 80.000 and Methodologies Piemonte CLI ORD Surgical, Biomedical Imaging, and Bioengineering 15,5 110.000 Toscana ORD Cell Biology 15,5 150.000 Liguria CLI ORD Digestive, Kidney 15,5 150.000 and Urological Systems Lombardia CLI ORD Infectious Diseases 15,5 150.000 and Microbiology Pagina 220 di 332

2320087 2319987 2321999 Hormonal changes and impaired spermatogenesis in young males with different levels of spinal cord injury: A longitudinal study Homocysteine serum levels in patients with cutaneous lupus erythematosus: pathogenetic and therapeutic implications. Prevention of recurrence of idiopathic calcium stones and risk of developing associated diseases: a study of salt sensitivity genetics, urinary phenotype risk and body composition. MAUGERI CLI EST Endocrinology, Metabolism, Nutrition and Reproductive 15,5 150.000 Toscana CLI ORD Musculoskeletal, 15,5 160.000 Oral and Skin Emilia Romagna CLI ORD Digestive, Kidney 15,5 180.000 and Urological Systems 2316795 Interim FDG PET/CT in the assessment of early response to concurrent chemo radiotherapy in patients with non small cell lung cancer stage IIIA IIIB ARCISPEDALE CLI ORD Oncology 2 15,5 190.000 2308715 Hepatitis E: break the chain between animals and human Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia CLI ORD Veterinary 15,5 195.000 2309608 IL 21 based immunotherapy for disseminated neuroblastoma: a preclinical study IRCCS AOU San Martino IST (Genova) ORD Oncology 2 15,5 200.000 2305356 Urinary FDG loss and measurement of standardized uptake value "SUV" IRCCS AOU San Martino IST (Genova) ORD Surgical, Biomedical Imaging, and Bioengineering 15,5 203.000 2319065 A rehabilitation tool for motor impairement: action observation S.CAMILLO CLI ORD Biobehavioral and 15,5 203.700 Behavioral Processes 2315051 Resistin as a biomarker of coronary artery disease, major cardiovascular events and all cause mortality in patients with type 2 diabetes. CASA SOLLIEVO SOFFERENZA ORD Vascular and 15,5 210.000 Hematology Pagina 221 di 332

2318450 2313440 2318812 Neuropsychological and imaging characterization of cognitive decline in Parkinson s disease Molecular tools for the diagnosis and treatment of early placentation defects and related pregnancy pathologies Experience dependent molecular and cellular mechanisms of vestibular compensation S.CAMILLO CLI ORD Brain Disorders and 15,5 210.000 BURLO GAROFALO EST Endocrinology, Metabolism, Nutrition and Reproductive 15,5 225.000 Piemonte ORD Molecular, Cellular, 15,5 235.000 and Developmental 2310730 Genetic polymorphisms in genes of drug related and DNA repair pathways as predictive markers of the therapeutic efficacy in esophageal carcinoma. I. O. V. CLI ORD Oncology 2 15,5 240.000 2304835 2315471 D.A.I.P.P. Assessment of influencing factors in diabetes incidence and progression in paediatric immigrant population Muscle Catabolism Fuels Anabolic Tumor Growth: and Therapeutic Implications Piemonte CLI ORD Healthcare Delivery and Methodologies 15,5 245.000 GASLINI EST Oncology 1 Basic 15,5 258.000 2318318 ROLE OF HUMAN PAPILLOMAVIRUS IN THE DEVELOPMENT OF PENILE CANCER IN PATIENTS WITH LICHEN SCLEROSUS: CLINICAL, VIDEODERMATOSCOPIC, HISTOPATHOLOGIC AND MOLECULAR STUDY Sicilia CLI ORD Oncology 1 Basic 15,5 270.000 2308132 The pathophysiology of alpha synuclein toxicity and infectivity in Parkinson s disease: molecular mechanisms and therapeutic implications FATEBENEFRATELLI ORD Brain Disorders and 15,5 280.000 Pagina 222 di 332

2318086 The burden of arterial and venous thromboembolism in the Italian active population: a twenty years long prospective VITA (VIcenza Thrombophilia and Atherosclerosis) COhort STudy (VITA COST) Veneto CLI ORD Vascular and 15,5 280.000 Hematology 2318110 Novel approaches to the functional characterization of unclassified variants in BRCA genes. ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 15,5 298.650 2320211 2298972 2320553 Unravelling new cellular and molecular mechanisms of Myotonic Dystrophy (DM) phenotype through the use of DM derived Induced Pluripotent Stem Cells (ipscs) Role of local synthesis and of systemic administration of Brain Derived Neurotrophic Factor (BDNF) in the striatum of the murine model of Huntington s disease. Carcinogenic potential of Lipofilling (LF) and Adipose Derived Stem Cells (ADSCs) in breast cancer SANTA LUCIA ORD Genes, Genomes 15,5 300.000 and Genetics SANTA LUCIA ORD Brain Disorders and 15,5 300.000 Sicilia ORD Oncology 1 Basic 15,5 300.000 2318568 Analysis of myocardial function after aortic valve replacement with a novel sutureless valve: coupling mathematical models to clinical research. Sicilia CLI ORD Cardiovascular and 15,5 300.000 Respiratory 2309071 Neurological and visual impairment in Cobalamin C defect: a novel therapeutical approach based on antioxidant therapy OSPEDALE BAMBINO GESU' CLI ORD Brain Disorders and 15,5 300.000 2305056 Cancer and Heart study: Cancer from Radiological medical imaging in cardiovascular patients Toscana CLI EST Cardiovascular and 15,5 301.000 Respiratory Pagina 223 di 332

2318862 2310448 Cross Sectional study to evaluate the interactions between gut microflora and immune system at the cross road of the pathogenesis of Inflammatory Bowel Diseases and Irritable Bowel Sydrome Istituto Superiore di Sanita' ORD Infectious Diseases 15,5 308.000 and Microbiology Role of extracellular Tat in HIV infection Istituto Superiore di Sanita' ORD AIDS and Related 15,5 333.333 Research 2308521 2319031 2317368 2321292 2319204 2312269 Assessment of the role of image guided radiotherapy (IGRT) in the treatment of head and neck cancers. A randomized phase III study of chemo radiation for stage III IVa oropharynx cancers: IGRT Intensity Modulated Radiotherapy (IMRT) with dose fraction esc ErbB2 blockade induces myocardial dysfunction, countered by PDE5 inhibition, and by enhancement of myocytes Ca2+ cycling and myofilaments Ca2+ sensitivity, and by melusin cardiac overexpression Allergic contact dermatitis to nickel and related alloys Detailed virological characterisation of patients with virological failure receiving integrase inhibitors and/or CCR5 inhibitors: RNA and DNA resistance profile, plasma and cell viral load, V3 loop characterisation and pharmacokinetic profile Targeting mitochondria associated Heat Shock Proteins, autophagy and bioenergetics in human solid tumors Neural response to behavioral treatments in Focal Hand Dystonia ARCISPEDALE CLI ORD Oncology 2 15,5 350.000 PASCALE ORD Cardiovascular and 15,5 361.000 Respiratory SAN GALLICANO ORD Cardiovascular and 15,5 380.000 Respiratory Istituto Superiore di Sanita' ORD AIDS and Related 15,5 380.000 Research MAGGIORE EST Oncology 2 15,5 380.000 Veneto CLI EST Brain Disorders and 15,5 385.000 Pagina 224 di 332

2309199 2304924 Brain heart axis impairment in stroke patients: integration of neuroimaging data with cardiovascular variability signals. Molecular characterization of IFI16 protein: development of new diagnostic and therapeutic tools for autoimmunity Istituto Superiore di Sanita' EST Brain Disorders and 15,5 395.000 Piemonte ORD Immunology 15,5 400.000 2319469 Vibrio and viruses in shellfish: old and emerging pathogens. Evaluation of exposure levels for the implementation of prevention strategies. Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 15,5 400.000 2316035 2312283 2321042 EVALUATION OF HUMORAL AND CELLULAR REACTIVITY IN KIDNEY ALLOGRAFT PATIENTS: NEW TOOL TO TRIM THE IMMUNOSUPPRESIVE THERAPY IN ACCORDING TO THE AGE High resolution array CGH study in patients with infancy epileptic encephalopathies of unknown etiology. Neural correlates of apathy and Executive Dysfunction in Parkinson s disease. Piemonte CLI ORD Immunology 15,5 400.000 OASI MARIA S.S. ORD Brain Disorders and 15,5 420.000 NEUROLESI EST Brain Disorders and 15,5 420.000 2317162 Persistence and adaptation mechanisms of clinical methicillin resistant Staphylococcus aureus clones SAN RAFFAELE MONTE TABOR ORD Infectious Diseases 15,5 423.500 and Microbiology 2320959 2319039 Role of polymorphisms of genes involved in alloreactive response in kidney transplantation: implications for personalized post transplant therapies Alzheimer's disease and insulin resistance: new biomarkers for early detection Abruzzo ORD Immunology 15,5 429.000 Piemonte CLI ORD Biology of 15,5 429.900 Development and Aging Pagina 225 di 332

2315767 2311534 Rising up brain activity by non invasive brain stimulation to improve cognitive and behavioural abilities in patients with Alzheimer s disease Novel strategies in the pathogenesis, epidemiology and prognostic factors of papillary thyroid cancer FATEBENEFRATELLI ORD Biobehavioral and 15,5 436.700 Behavioral Processes Toscana ORD Endocrinology, Metabolism, Nutrition and Reproductive 15,5 450.000 2317225 Relationship between iron metabolism and proteasome functionality suggests novel therapeutic strategies for Multiple Myeloma SAN RAFFAELE MONTE TABOR ORD Oncology 2 15,5 450.000 2316281 2310894 2311365 2306180 2314344 UPPER LIMB IMPAIRMENT IN CHARCOT MARIE TOOTH PATIENTS: MOTOR STRATEGIES, IMPACT ON QUALITY OF LIFE AND CORTICAL FUNCTIONAL REORGANIZATION Molecular subtype based follow up program in patients treated for early breast cancer Non invasive assessment of liver steatosis and fibrosis, and lymph nodes diseases in pediatric patients. Development of Training Optimization Techniques for Robot assisted Neurorehabilitation. Effects of an educational intervention for reducing inappropriate prescribing in elderly exposed to polypharmacy in general practice DON GNOCCHI CLI ORD Musculoskeletal, 15,5 450.000 Oral and Skin Emilia Romagna CLI ORD Oncology 2 15,5 450.000 SAN MATTEO CLI ORD Surgical, Biomedical Imaging, and Bioengineering 15,5 450.000 MAUGERI EST Brain Disorders and 15,5 450.000 Lombardia CLI ORD Healthcare Delivery 15,5 450.200 and Methodologies Pagina 226 di 332

2312206 MicroRNAs as potential diagnostic and therapeutic tools for Multiple Osteochondromas disease RIZZOLI EST Musculoskeletal, 15,5 468.000 Oral and Skin 2316393 POSSIBLE ROLE OF 18F FDG PET/CT IN DEFINING THE APPROPRIATE USE OF PRRT IN PATIENTS WITH METASTATIC GEP NETs WITH EVIDENCE OF TUMOUR PROGRESSION FOLLOWING TREATMENT WITH SOMATOSTATIN ANALOGUES. ISTITUTO TUMORI MILANO CLI ORD Oncology 2 15,5 468.600 2319421 Liver Factory SAN MATTEO ORD Surgical, Biomedical Imaging, and Bioengineering 15,5 470.000 2311688 2309568 2319406 2318011 2318972 ANORECTAL MALFORMATIONS (ARM): A MULTIDISCIPLINARY RESEARCH TO IDENTIFY PREDISPOSING FACTORS AND NEW THERAPEUTICAL APPROACHES Genetic predisposition to severe and recurrent infections: unravelling the pathogenic mechanisms of susceptibility Neurophysiological indices of functional network integration in vegetative and minimally conscious patients and their relation to awareness and prognosis p38 MAP kinase signalling pathway in T cell commitment and senescence in Autoimmunity Food pyramids and nutritional prevention campaigns Veneto ORD Genes, Genomes 15,5 475.000 and Genetics SAN MATTEO CLI ORD Immunology 15,5 480.000 SANTA LUCIA CLI EST Brain Disorders and 15,5 490.000 SANTA LUCIA ORD Immunology 15,5 500.000 CROB ORD Healthcare Delivery 15,5 500.000 and Methodologies Pagina 227 di 332

2315397 2319567 2314370 2321069 Cognitive and physical trainings to improve the clinical outcome in Alzheimer s disease by modulation of brain plasticity: a clinical and MRI investigation Innovative biomarkers for prevention, diagnosis and prognosis of colorectal cancer Identification of novel genetic alterations and key cellular pathways to be targeted in acute myeloid leukemia. PATOPHISIOLOGY EVALUATION OF THE LUNG WITH MECHANICAL ASSESTMENT PRE AND POST ENDOSCOPIC VOLUMETRIC REDUCTION IN THE TREATMENT OF PATIENTS WITH SEVERE ENFISEMA SANTA LUCIA CLI ORD Brain Disorders and 15,5 500.000 ARCISPEDALE ORD Oncology 2 15,5 514.000 Veneto ORD Oncology 1 Basic 15,5 544.000 Emilia Romagna CLI ORD Cardiovascular and 15,5 545.500 Respiratory 2316975 High throughput sequencing to reveal the undesired microbiota in raw cheeses Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 15,5 550.000 2313328 Imaging and molecular analysis of brain inflammation in depression: a translational approach SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 15,5 550.000 2311662 2317543 Development and preclinical testing of novel adenosine 2A receptor antagonists for the treatment of Parkinson s disease and clinical implementation of potential adenosine receptorrelated biomarkers Air pollution, Epigenomic Arterial Signatures, and Post Heart Surgery Risk of Cardiovascular Events MONDINO ORD Brain Disorders and 15,5 560.000 MAGGIORE EST Genes, Genomes 15,5 570.000 and Genetics Pagina 228 di 332

2307444 2314655 2318842 Na+ Ca2+ exchanger 1 (NCX1) as new potential therapeutic target in the management of bacteriainduced heart hypertrophy and related complications A multidisciplinary approach to personalized medicine in CRC The Salivary Proteomics biomarkers for Alzheimer's disease study (SaP AD study) Marche ORD Cardiovascular and 15,5 575.000 Respiratory Sicilia CLI ORD Oncology 2 15,5 595.000 Sicilia ORD Brain Disorders and 15,5 600.000 2315569 Calcific arteriopathy in chronic kidney disease: genetic determinants, molecular biology and clinical markers SAN RAFFAELE MONTE TABOR ORD Biology of 15,5 600.000 Development and Aging 2306708 2310252 2319201 2319131 Development of an easily available Monte Carlo based tool to improve dose delivery accuracy in helical tomotherapy DESIGN AND TEST OF A SPECIFIC CUSTOM ARRAY CGH FOR GENOME WIDE COPY NUMBER VARIATIONS (CNVs) AND NEXT GENERATION SEQUENCING OF CANDIDATE GENES IN HYPERTROPHIC CARDIOMYOPATHY Development of tailored treatments targeting biologic hallmarks in chronic lymphocytic leukemia (CLL) Global and gene specific DNA methylation in maternal infant pairs, environmental exposures, and subsequent respiratory and neurobehavioral phenotypes in childhood Istituto Superiore di Sanita' ORD Oncology 2 15,5 600.000 Liguria ORD Genes, Genomes 15,5 600.000 and Genetics Piemonte ORD Oncology 1 Basic 15,5 600.000 Lazio EST Genes, Genomes 15,5 600.000 and Genetics Pagina 229 di 332

2315123 FACES IV: A DIAGNOSTIC INSTRUMENT TO EVALUATE FAMILY FUNCTIONING IN A SAMPLE OF PATIENTS IN THE PEDIATRIC AGE OSPEDALE BAMBINO GESU' CLI ORD Biobehavioral and 15,75 150.700 Behavioral Processes 2319470 2317071 2320070 2307421 ELBA.PSDEcological Language Behaviour Assessment For Post Stroke Dementia Mice models of osteosarcoma and hemangiosarcoma development. Early molecular and immunological mechanisms involved in tumor onset and malignancy as targets of innovative therapies. Molecular profiling of malignant tumors of the nose and paranasal sinuses: evaluation of diagnostic, prognostic and therapeutic implications Early non invasive molecular diagnosis of prostate cancer:role of cell free DNA in blood and urine S.CAMILLO CLI EST Biobehavioral and 15,75 200.000 Behavioral Processes RIZZOLI ORD Oncology 1 Basic 15,75 260.000 Toscana ORD Oncology 1 Basic 15,75 280.000 Emilia Romagna ORD Oncology 1 Basic 15,75 390.000 2309551 2321986 Regulation of mtor functions by Che 1 REGINA ELENA ORD Oncology 1 Basic 15,75 500.000 Oxidative stress induced DNA damage response and autophagy in skeletal muscle cells: mechanisms and implication for muscle dystrophy SANTA LUCIA EST Biology of 15,75 600.000 Development and Aging 2311912 Lower limb robotic exoskeleton for children with motor impairment OSPEDALE BAMBINO GESU' CLI EST Musculoskeletal, 15,75 600.000 Oral and Skin 2318438 PROBING THE ROLE OF ION CHANNELS IN NEUROPATHIC PAIN CARLO BESTA ORD Molecular, Cellular, 15,8 600.000 and Developmental Pagina 230 di 332

2309530 2321787 2316774 2315143 2310093 INNOVATIVE TREATMENTS FOR NEUROGENETIC DISEASES AND THEIR COMPLICATIONS: ATAXIA TELANGIECTASIA Ventricular tachyarrhythmias associated with cardiac hypertrophy and myocardial infarction: implications for early recognition of micrornas levels and treatment Biomolecular characterization of new histone deacetylase inhibitors in uveal melanomas Extraneuronal airway cholinergic system and ß2ARs function in stable COPD and control subjects Analysis of causative genes in patients with Frontotemporal Lobar Degeneration and study of genotype phenotype correlations. Lazio CLI ORD Genes, Genomes 15,83 115.000 and Genetics Calabria ORD Cardiovascular and 16 75.000 Respiratory Sicilia ORD Oncology 2 16 150.000 Emilia Romagna ORD Cardiovascular and 16 150.000 Respiratory Toscana ORD Genes, Genomes 16 150.000 and Genetics 2317708 Intraoperative Calcitonin Monitoring as marker of disease cure after surgery and indicator of type of surgery in patients with Medullary Thyroid Cancer PASCALE CLI ORD Oncology 2 16 150.000 2320554 Translation of in vitro and in vivo ascorbate research into a new loco regional treatment option for colo rectal cancer liver metastases not eligible for surgical resection: Phase I/II Trial Sicilia CLI ORD Oncology 2 16 150.000 2317558 Development of pre operative investigation tools and surgical procedures for the treatment of movement disorders in childhood OSPEDALE BAMBINO GESU' COF Brain Disorders and 16 150.000 2321051 management of viral infections in pediatric hematopoietic stem cell transplant recipients. Piemonte CLI ORD Infectious Diseases 16 150.000 and Microbiology Pagina 231 di 332

2313562 2317869 A randomized controlled, double blind study on the effect of chronic thyroid hormones administration on left ventricular remodellingin patients with heart failure and low T3 syndrome. Stratification of patients with chronic hepatitis C according to IL28B polymorphism and IFNstimulated genes (ISGs) expression: prediction of response to antiviral treatment and selection for individualized therapy schedules. Sicilia CLI ORD Cardiovascular and 16 200.000 Respiratory Piemonte CLI ORD Digestive, Kidney 16 200.000 and Urological Systems 2318214 Major Congenital Malformation: Long term Health Related Quality of Life of Patients and their Families OSPEDALE BAMBINO GESU' CLI ORD Healthcare Delivery 16 200.000 and Methodologies 2315790 KNEE rehabilitation after Anterior Cruciate Ligament reconstruction: design, development and METROlogical characterization of computational methods and digital (wireless) data communication protocols for improving therapy effectiveness and medical operat Umbria ORD Surgical, Biomedical Imaging, and Bioengineering 16 204.445 2317557 2312543 2313948 Safety profile and prescribing pattern of psychotropic medications in childhood. Fighting intestinal schistosomiasis: novel targets for drugs and diagnostics Overweight, Obesity and Risk of Western Disease(WD): a cohort prospective study in a mediterranean area Sicilia CLI ORD Brain Disorders and 16 205.000 Lazio ORD Infectious Diseases 16 210.000 and Microbiology DE BELLIS ORD Population 16 210.000 and Epidemiology 2314955 Evaluation of long term health issues of adult women with a Disorder of Sex Development (DSD) attending the first Italian Adult DSD Clinic. Emilia Romagna CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 16 210.000 Pagina 232 di 332

2320306 2312694 2313742 2321872 2319182 2314830 2318751 2310609 G protein coupled receptor 35 as a new target in the treatment of neuropathic pain Maternal metabolic hormones impact on human breast during pregnancy. A MULTIDISCIPLINARY EMERGENCY APPROACH TO IMPROVE QUALITY OF CARE AND REDUCE POST TRAUMATIC STRESS DISORDER IN CHILDREN EVALUATION OF PLATELET ACTIVATION BY CYTOFLUORIMETRIC ANALYSIS OF PAC 1 EXPRESSION IN PATIENTS WITH CHRONIC MYELOPROLIFERATIVE NEOPLASMS Molecular profiling of salivary gland cancer: evaluation of diagnostic, prognostic and therapeutic implications The hmena alternative splicing program and host immune response in EMT and breast tumor progression Inflammatory pathways, oxidative stress and ischemia/reperfusion injury in human donor hearts: a comparative analysis between accepted and refused grafts for transplantation ROLE OF ESTROGENS IN HUMAN HEPATOCELLULAR CARCINOMA: POTENTIAL IMPLICATIONS FOR PREVENTION AND TREATMENT Toscana ORD Molecular, Cellular, 16 220.000 and Developmental Abruzzo CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 16 220.000 Emilia Romagna CLI ORD Healthcare Delivery 16 240.000 and Methodologies Emilia Romagna ORD Vascular and 16 280.000 Hematology Toscana ORD Oncology 2 16 280.000 REGINA ELENA EST Oncology 1 Basic 16 280.000 Lombardia CLI ORD Cardiovascular and 16 281.270 Respiratory Sicilia ORD Oncology 1 Basic 16 282.000 Pagina 233 di 332

2305498 2301332 Folic acid assumption in late pregnancy and its interaction with parental and fetal genes in childhood asthma development Epidemiology, Biomolecular Characterization, Phylogenetic Analysis, and Evaluation of Urine Testing Strategy for Diagnosis of Chlamydia and HPV Infections in Migrant Women with Limited Access to Health Care Istituto Superiore di Sanita' CLI ORD Population and Epidemiology 16 286.000 Lombardia CLI ORD Infectious Diseases 16 292.100 and Microbiology 2320005 Aggressive angiomyxoma: pattern of presentation and molecular expression in a multicenter series ISTITUTO TUMORI MILANO CLI ORD Oncology 2 16 298.660 2310895 Cardiac output regulation in artificial hearts MONZINO CLI ORD Cardiovascular and 16 299.200 Respiratory 2321005 2312095 2316153 2311483 2315568 Study of SP A polymorphisms as a predictor of over all lung transplant outcome. Rehabilitation in Chronic Disability: Connecting Care 2.0 Harnessing reactive oxygen species to target cancer cells Safety and efficacy of the Drug Eluting Balloon (DEB) vs plain balloon angioplasty for the treatment of the Superficial Femoral Artery (SFA) ischemic vascular disease in symptomatic patients presenting with long lesions: a randomised study. and molecular genetic spectrum of Coenzyme Q10 deficiencies: identifications of new phenotypes and genetic variants. Implications for the pathogenesis and therapeutic approach. SAN MATTEO EST Cardiovascular and Respiratory 16 300.000 Lombardia CLI ORD Healthcare Delivery 16 300.000 and Methodologies I. O. V. ORD Oncology 1 Basic 16 310.000 SAN RAFFAELE PISANA CLI ORD Cardiovascular and Respiratory 16 320.000 NEUROLESI CLI EST Genes, Genomes 16 338.000 and Genetics Pagina 234 di 332

2321719 2318564 2320522 2302378 2315144 2319783 2307536 2315894 2321689 Statistical methods for the detectection of Genomic Copy Number Variants from High Throughput Sequencing data Protein synthesis and atrophy regulation by metabolic modulators. Potential role in the treatment of muscle wasting disorders. Three key drugs in newborns: a novel approach for micro dosingby mean of advanced mass spectrometry techniques "Leading nanomedicine into the therapy for Leukodystrophies: nanoparticles overcoming the blood brain barrier to treat the mouse model of Krabbe Disease" Extracorporeal lung perfusion and ventilation to improve donor lung function and increase the number of organs available for transplantation. Preventing onset of psychosis in high risk youths: identification and treatment MicroRNA regulation of cellular signalling pathways: Identification of prognostic and therapeutic biomarkers in high risk soft tissue sarcoma patients Bone Morphogenetic Protein pathway induces Cancer Stem Cells differentiation enhancing the chemosensitivity of breast and colorectal cancers to conventional chemotherapy Quitline for smoking cessation in women adhering cervical cancer screening Toscana ORD Genes, Genomes 16 344.444 and Genetics SAN RAFFAELE PISANA ORD Biology of 16 350.000 Development and Aging Toscana CLI ORD Cardiovascular and 16 350.000 Respiratory BURLO GAROFALO ORD Molecular, Cellular, 16 380.000 and Developmental MAGGIORE CLI ORD Cardiovascular and 16 380.000 Respiratory MONDINO CLI EST Brain Disorders and 16 396.000 RIZZOLI ORD Oncology 1 Basic 16 400.000 Sicilia ORD Oncology 2 16 400.000 Piemonte CLI ORD Risk, Prevention 16 400.000 and Health Behavior Pagina 235 di 332

2310212 2319006 2300170 2311423 2307608 2321537 2307162 INTERMEDIATE INTENSIVE CARE UNIT (IICU CRITICAL AREA ) In vitro and in vivo models for the functional study of a complicated form of hereditary spastic paraplegia (SPG9). Impact of influenza vaccination in HIV 1 multitreated elderly patients Evaluation of CARDIac function in patients with chronic LIVER disease (CARDIO LIVER) Postmenopausal Women s Bone Health: A Novel Approach to Prevent fragility fracture Prevalence and clinical impact of Chronic Obstructive Pulmonary Disease (COPD) in patients with cardiovascular disease and predictive power of cardiovascular risk factors in patients with COPD Indolent non follicular lymphomas prognostic project (NF2010 study) on behalf of the Italian Lymphoma Foundation (FIL) Emilia Romagna CLI ORD Healthcare Delivery 16 409.000 and Methodologies Emilia Romagna ORD Genes, Genomes 16 413.000 and Genetics Istituto Superiore di Sanita' EST AIDS and Related 16 435.000 Research Toscana CLI ORD Surgical, Biomedical Imaging, and Bioengineering 16 436.600 Calabria CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 16 450.000 SAN RAFFAELE PISANA CLI ORD Cardiovascular and 16 450.000 Respiratory SAN MATTEO CLI ORD Oncology 2 16 450.000 2318918 2317064 New strategies for craniofacial tissue engineering MAUGERI ORD Bioengineering 16 470.000 and Technologies Biocompetent dendrons (BD) vs platelet rich plasma (PRP) finalized to induce angiogenesis and bone regeneration in osteonecrosis. Marche EST Musculoskeletal, 16 480.000 Oral and Skin Pagina 236 di 332

2310905 2312025 Gene identification in muscle disorders disrupting cell extracellular matrix interactions A health technology life cycle model from emerging to obsolete technologies CARLO BESTA EST Musculoskeletal, 16 480.500 Oral and Skin Veneto CLI ORD Healthcare Delivery 16 489.000 and Methodologies 2312711 Ultraviolet solar radiation and aromatic hydrocarbons as carcinogenic factors in outdoor workplaces: exposure quantification and biomarkers identification aimed at the identification of principal effects and possible synergistic effects Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro ORD Population 16 497.572 and Epidemiology 2304828 2318009 2308966 2321531 TRAIL producing UC MSCs as cytotherapy to defeat multiple myeloma: a preclinical study. Cardiotoxicity of anticancer treatments. Biomarkers and diagnostic tools for evaluation of cardiological risk of oncological patients Effect of eyes covering on variations of melatonin secretion, electroencephalographic pattern and outcome in patients with severe neurological damage. Evaluation of the pharmaco/toxicological profile of new smart drugs of abuse and optimization of targeted analytical procedures for their detection in biological samples ONCOLOGICO DI BARI ORD Oncology 2 16 499.000 MULTIMEDICA CLI ORD Cardiovascular and 16 499.844 Respiratory Emilia Romagna ORD Brain Disorders and 16 500.000 Toscana ORD Risk, Prevention 16 500.000 and Health Behavior 2305610 Modulation of integrin binding selectivity: a computational approach SAN RAFFAELE MONTE TABOR ORD Biological Chemistry and Macromolecular Biophysics 16 500.000 Pagina 237 di 332

2319594 Osteosarcoma and vanilloid/cannabinoid system: new disease markers and new therapeutic targets OSPEDALE BAMBINO GESU' ORD Musculoskeletal, 16 500.000 Oral and Skin 2309735 Identification of organs that are reservoir of immunosoppressive cells during tumor development and progression SAN RAFFAELE MONTE TABOR ORD Immunology 16 509.000 2315239 2313587 Neurological and clinical study of Prevalence and Incidence of Dementia in Posttraumatic Stress Disorder patients Insights into oxidative stress induced modification of creatine kinase in human heart failure: epiphenomenon or mechanicistic marker? NEUROLESI ORD Brain Disorders and 16 510.180 MONZINO ORD Cardiovascular and 16 525.000 Respiratory 2301784 Pharmacological enhancement of tumor cell death ISTITUTO TUMORI by soluble or membrane bound TRAIL and SMACmimetics MILANO ORD Oncology 1 Basic 16 580.000 2306447 2315820 2314686 2319291 2315859 Large scale exome sequencing in familial and sporadic amyotrophic lateral sclerosis. Innovative combinatorial therapeutic strategies to revert resistance to target therapy in NSCLC Epigenetic determinants of psoriasis and psoriatic arthritis: diagnostic and prognostic values of DNA methylation patterns Role of regulatory cells and cytokines in the extent of colonic involvement in patients with ulcerative colitis MicroRNA regulation in the pathogenesis of MD and in the mechanism of action of antidepressant drugs AUXOLOGICO ORD Brain Disorders and 16 580.000 PASCALE EST Oncology 2 16 580.000 Emilia Romagna ORD Musculoskeletal, 16 595.000 Oral and Skin Istituto Superiore di Sanita' ORD Digestive, Kidney 16 599.500 and Urological Systems FATEBENEFRATELLI ORD Biobehavioral and 16 600.000 Behavioral Processes Pagina 238 di 332

2320674 NeuronHeart Cytoskeletal proteins of neurons confer cardioprotection against myocardial infarction Toscana ORD Cardiovascular and 16 600.000 Respiratory 2315572 Russell Bodies: biophysics and biology of proteostasis in an ER storage disorder. SAN RAFFAELE MONTE TABOR ORD Biological Chemistry and Macromolecular Biophysics 16 600.000 2321390 Nanomedicine applied to cerebral ischemia NEUROLESI ORD Brain Disorders and 16 600.000 2319408 2320428 Inhibiting p38alpha in colorectal cancer: moving beyond the Warburg effect Role of nicotinic receptor subtypes in alcoholtobacco dependence DE BELLIS ORD Oncology 2 16 600.000 Emilia Romagna ORD Genes, Genomes 16 600.000 and Genetics 2306484 Human infection from exposure to norovirus: improving diagnostic techniques and correlation analysis between clinical cases and infected food. Developing a network among hospital units and IIZZSS in some Italian regions Istituto Zooprofilattico Sperimentale delle Venezie ORD Infectious Diseases 16 600.000 and Microbiology 2313066 One year follow up of infected fetuses.1) Implementation of clinical pathways for an appropriate/comprehensive care of women infected during pregnancy and of infants with congenital infection.2) Role of innate immunity in the susceptibility to infect OSPEDALE BAMBINO GESU' CLI ORD Infectious Diseases 16 600.000 and Microbiology 2318826 2313580 Autoimmunome driven immunotherapy of Alzheimer's Disease Non invasive brain stimulations: EEG reactivity in vegetative and minimal conscious state patients Piemonte EST Brain Disorders and 16,25 280.000 S.CAMILLO CLI ORD Brain Disorders and 16,25 300.000 Pagina 239 di 332

2314408 2314905 2312367 2314969 2320315 2314302 and molecular mechanisms of accelerated aging in dialysis patients. Therapeutic heart rate lowering in coronary artery disease patients and endothelial shear stress: the likely beneficial link Familial hyperlipidemias: new diagnostic approaches A new treatment of depression in the elderly: positive memory neurostimulation as an alternative to antidepressants? Prognosis and therapeutic biomarkers of prostate cancer Next Generation Sequencing platform for targeted Personalized Therapy of Leukemia (NGS PTL) Abruzzo ORD Biology of 16,25 376.000 Development and Aging MAUGERI ORD Cardiovascular and 16,25 425.000 Respiratory SDN ORD Genes, Genomes 16,25 490.000 and Genetics NEUROLESI CLI ORD Biobehavioral and 16,5 143.000 Behavioral Processes Puglia ORD Oncology 2 16,5 150.000 Emilia Romagna ORD Oncology 2 16,5 150.000 2315504 HER2 status and outcome in refractory advanced colorectal cancer (CRC) patients (pts) treated with cetuximab based chemotherapy Emilia Romagna ORD Oncology 2 16,5 150.000 2299434 Comparison of next generation sequencing based identification of translocations with copy number alteration based identification of deletions for the development of patient/tumor specific real time PCR assays for detection of minimal residual disease usin IRCCS AOU San Martino IST (Genova) CLI COF Oncology 2 16,5 150.000 2311899 Intensive nutritional counseling and quality of life in patients affected by non small cells lung cancer: a randomized controlled trial Lombardia CLI ORD Oncology 2 16,5 155.000 Pagina 240 di 332

2309109 2306837 2317677 2318207 IDENTIFICATION OF NOVEL LOGICAL AGENTS FOR THE SYSTEMIC TREATMENT OF MALIGNANT PLEURAL MESOTHELIOMA: TRAIL MEDIATED APOPTOSIS SENSITIZATION THROUGH REACTIVE OXYGEN SPECIES (ROS) INDUCTION AND INHIBITORS OF APOPTOSIS PROTEIN (IAP) SILENCING. Search for new mutations and polymorphisms of FSHR and LHR genes in hypergonadotropic hypogonadic patients without obvious testicular pathogenic noxa. Evaluation of predictors of nimesulide induced liver injury by analysis of individual genetic susceptibility Detection and management of Thyroid nodules: assessment of a screening program carried out by General Practitioners I. O. V. ORD Oncology 2 16,5 180.000 Toscana CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 16,5 183.000 Sicilia ORD Digestive, Kidney 16,5 184.000 and Urological Systems ARCISPEDALE CLI ORD Healthcare Delivery 16,5 187.000 and Methodologies 2311634 Multidisciplinary vs Monodisciplinary Clinic for Prostate Cancer Patients: Evaluating Patients Satisfaction and Multidisciplinary Team Working ISTITUTO TUMORI MILANO CLI ORD Healthcare Delivery 16,5 189.500 and Methodologies 2313912 2316723 Salivary gland tumours: molecular and molecularcytogenetic studies to identify diagnostic/prognostic markers and risk factors THOROUGH DEFINITION OF HER2 AND CHROMOSOME 17 STATUS IN BREAST AND GASTRIC CANCER: A CRUCIAL STEP TO DELIVER THE RIGHT THERAPY TO THE RIGHT PATIENT Istituto Superiore di Sanita' ORD Genes, Genomes and Genetics 16,5 201.300 Piemonte CLI ORD Genes, Genomes 16,5 210.000 and Genetics Pagina 241 di 332

2317988 2319100 2312352 SiPIMIS (Single Portal with Intraperitoneal Magnetic Instruments Surgery): a brand new no scar surgical approach for major abdominal intervention. Incidence of Oropharyngeal/oral cancer and Human Papillomavirus (HPV) in Italy and Prevalence of High Risk HPV in oral exfoliated cells in the general population A molecular approach to identify carotid plaque vulnerability for stroke prevention Lombardia EST Surgical, Biomedical Imaging, and Bioengineering 16,5 210.540 Toscana ORD Population 16,5 240.000 and Epidemiology Emilia Romagna ORD Vascular and 16,5 240.680 Hematology 2309778 PAIN AND ANALGESIA IN THE PRETERM NEWBORN: A LONGITUDINAL STUDY ON NON PHARMACOLOGIC METHODS EFFICACY AND THEIR INFLUENCE ON PAIN PROCESSING CORTICAL MATURATION BURLO GAROFALO CLI ORD Brain Disorders and 16,5 275.000 2309189 Role of mutant p53/polo like kinase 2 axis in tumor progression and in the maintenance of genomic instability in cancer cells REGINA ELENA ORD Cell Biology 16,5 294.000 2312357 The role of diet in psoriasis ISTITUTO DERMOPATICO DELL'IMMACOLATA CLI ORD Risk, Prevention 16,5 297.000 and Health Behavior 2306088 EasyHIFU: simplified lesion localization for HIFU treatment Toscana CLI ORD Surgical, Biomedical Imaging, and Bioengineering 16,5 298.000 2316882 Interaction between environmental, noninfectious stressors and the type I Interferon system: a pig model of response to mycotoxins Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Immunology 16,5 300.000 Pagina 242 di 332

2320874 The proteomic profile of breast cancer: an innovative approach using bottom/up mass spectrometry and MALDI imaging IRCCS AOU San Martino IST (Genova) ORD Oncology 2 16,5 300.000 2321205 2321452 2319299 Correlation between clinical pathological features and gene expression profile in pediatric tumors of glial origin. Development of non invasive multimodal techniques for the diagnosis and characterization of epilepsy Immunopathogenetic mechanisms of idiopathic retroperitoneal fibrosis Liguria ORD Oncology 1 Basic 16,5 305.120 Toscana ORD Surgical, Biomedical Imaging, and Bioengineering 16,5 327.900 Emilia Romagna ORD Immunology 16,5 330.000 2311488 High throughput parallel sequencing of Mycobacterium avium subsp. paratuberculosis in sheep, of affected/non affected sheep transcriptome and of environmental samples. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana ORD Veterinary 16,5 350.000 2308327 Therapeutic targeting of HSP105 in human non Hodgkin lymphomas ISTITUTO TUMORI MILANO ORD Oncology 2 16,5 360.000 2319240 ROLE OF FIBROBLASTS IN THE PATHOGENESIS OF DERMATITIS HERPETIFORMIS AND CELIAC DISEASE MAGGIORE ORD Immunology 16,5 377.000 2305867 New predictive markers of response to chemoradiotherapy in rectal cancer: microrna 17 92 and methylation profile Emilia Romagna ORD Oncology 1 Basic 16,5 400.000 2308734 Study of the combined effects of Low Level Laser Therapy (LLLT) and bioactive coating on bone deposition and resorption. MAUGERI ORD Bioengineering 16,5 400.000 and Technologies Pagina 243 di 332

2315622 MOLECULAR CHARACTERIZATION OF COXIELLA BURNETII ISOLATES BY RAPD AND MLVA ANALYSES Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 16,5 400.000 2318622 Validation of MRI and PET markers for cellular and molecular features of human brain tumors: definition of their prognostic and therapeutic value. SAN RAFFAELE MONTE TABOR CLI ORD Surgical, Biomedical Imaging, and Bioengineering 16,5 400.000 2304836 2321086 2320073 2309032 2308881 2313248 Role of Mcl 1 protein in tumor angiogenesis and progression ROLE OF OXIDATIVE AND NITROSATIVE STRESS IN OBESE PREGNANT WOMEN PHARMACOGENETICS OF PEMETREXED AND CARBOPLATIN IN MALIGNANT PLEURAL MESOTHELIOMA (MPM) PATIENTS. Signaling pathways of healthy and unhealthy aging: a life long perspective Study of cerebral glucose metabolism by means of positron emission tomography (PET) in psoriatic patients with and without depression major before and after effective anti psoriatic therapies The pathogenetic role of serotonin and cytokines and the influence of nutritional and vitamin D deficiency on alterations of bone mineral metabolism in young women with chronic bowel diseases: a pilot study. REGINA ELENA EST Oncology 1 Basic 16,5 400.000 Marche ORD Endocrinology, Metabolism, Nutrition and Reproductive 16,5 408.000 HUMANITAS ORD Oncology 2 16,5 409.000 Istituto Superiore di Sanita' ORD Biology of 16,5 437.000 Development and Aging SAN GALLICANO ORD Musculoskeletal, 16,5 480.000 Oral and Skin AUXOLOGICO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 16,5 484.000 Pagina 244 di 332

2302686 Therapeutical approaches for diabetes due to the proteotoxic effect of misfolded insulin and betacellular ER stress OSPEDALE BAMBINO GESU' ORD Endocrinology, Metabolism, Nutrition and Reproductive 16,5 500.000 2312677 A Multi center 3T MR Assessment of T2 Perfusion and T1 Permeability in brain Gliomas: the MAPPING study SAN RAFFAELE MONTE TABOR CLI ORD Oncology 2 16,5 500.000 2319637 2318391 2312130 2317363 2315785 2311275 Structure, Function and New Insight Strategies for Prevention of Left Atrium Remodeling In Mouse Heart Failure PGD in genetic alteration and repeated failures in IVF patients Functional, structural and genetic correlates of cognitive and emotional impairments in Mood Disorders. PROTIC TREATMENT TO PREVENT ALLERGEN SENSITIZATION: A PRECLINICAL STUDY IN PREGNANT AND NEWBORN MICE Post translational modification of beta 2 glycoprotein I as candidate to modulate immune and endothelial cells homeostasis: implication in women with preeclampsia Multimodality MR imaging (DTI, fmri and quantitative relaxometry) for the evaluation of cerebral modifications induced by different rehabilitation protocols in children with cerebral palsy and traumatic brain injury. MONZINO EST Cardiovascular and 16,5 510.000 Respiratory Toscana CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 16,5 516.000 FATEBENEFRATELLI ORD Brain Disorders and 16,5 522.000 Istituto Superiore di Sanita' ORD Immunology 16,5 525.800 Istituto Superiore di Sanita' ORD Endocrinology, Metabolism, Nutrition and Reproductive 16,5 528.000 MEDEA CLI EST Brain Disorders and 16,5 545.000 Pagina 245 di 332

2320713 2313256 2316069 2308713 and experimental investigations of novel disease mechanisms in pain processing and Parkinson Disease CCRL2 as a new therapeutic target in rheumatoid arthritis TRANSLATIONAL APPLICATIONS ENSUING CIRCULATING IMMUNOCOMPLEXES AND CLINICAL APPROACHES IN GASTRIC CARCINOMA THAT PROVIDE INFORMATIVE CLUES FOR EARLY DIAGNOSIS AND TREATMENT OF GASTRIC CANCER Development of innovative methods for radiobiological optimization of radio nuclide therapy treatments MONDINO ORD Brain Disorders and 16,5 550.000 HUMANITAS ORD Immunology 16,5 550.000 C.R.O. AVIANO ORD Oncology 2 16,5 550.000 REGINA ELENA ORD Oncology 2 16,5 550.000 2317464 Development and validation of a set of indicators based on administrative data to monitor longterm care for disabled elderly Agenzia per i Servizi Sanitari Regionali CLI ORD Healthcare Delivery 16,5 550.000 and Methodologies 2309009 NMDA based pharmacotherapy associated to cue exposure therapy: a potential treatment for nicotine relapse FATEBENEFRATELLI ORD Brain Disorders and 16,5 568.500 2307416 Development of an innovative strategy based on the use of lytic bacteriophages for an effective and safe treatment of irrigation and washing waters of crops Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 16,5 575.000 2312350 PHENOTYPE VARIABILITY IN PRNP E200K MUTATION CARRIERS: A CLINICAL, GENETIC AND PROTEOMIC STUDY Istituto Superiore di Sanita' EST Genes, Genomes 16,5 580.000 and Genetics Pagina 246 di 332

2310740 2320210 2318449 Reshaping attention with rewards cracking the code of attentional biases in addiction Near infrared technology for trafficking the fate of stem cells in vivo: a translational study for longitudinal tracking in a rodent model of Parkinson s disease A Steam Cell based translational approach for early diagnosis and effective treatment of Hepatocellular Carcinoma. FATEBENEFRATELLI CLI ORD Integrative, Functional, and Cognitive 16,5 594.000 AUXOLOGICO ORD Emerging Technologies and Training in s 16,5 598.000 Friuli Venezia Giulia ORD Oncology 2 16,5 600.000 2311911 NEW MOLECULAR APPROACHES FOR THE DETECTION OF DIOXINS AND DIOXIN LIKE COMPOUNDS IN EXPOSED SHEEP Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary 16,5 600.000 2317030 Detection of Mycobaceterium avium subsp. paratuberculosis in human Crohn s disease and in ruminants and possible role of contaminated food Istituto Zooprofilattico Sperimentale del Mezzogiorno CLI ORD Infectious Diseases 16,5 600.000 and Microbiology 2320767 Drug Compliance in Allogeneic Stem Cell Transplantation (DAST) SAN RAFFAELE MONTE TABOR CLI ORD Healthcare Delivery 16,5 600.000 and Methodologies 2317952 A pharmacogenomic approach for Interferons treatment in multiple sclerosis SAN RAFFAELE MONTE TABOR CLI ORD Brain Disorders and 16,5 600.000 2317170 2312902 Prognostic role of arterial stiffness and vascular calcifications on peripheral arterial occlusive disease in chronic kidney disease. A multi center, observational, prospective, non invasive study. Assessment and management of risk factors for sleep disordered breathing and sleep bruxism in pediatric populations. The role of Orthodontics. AUXOLOGICO CLI ORD Vascular and 16,67 573.320 Hematology Emilia Romagna CLI EST Integrative, Functional, and Cognitive 16,75 85.000 Pagina 247 di 332

2319416 Performance of serum SMRP as screening tool (the cancer predictive values of SMRP ) surveilling a cohort of asbestos exposed individuals Liguria CLI ORD Oncology 2 16,75 125.000 2316361 2318142 2315308 Physiopathological mechanisms of freezing of gait in Parkinson disease and development of rehabilitative therapeutic strategies Predictive role of von Willebrand Factor changes in bleeding complication during continuous flow left ventricular assist device support The SHARP Study: Simultaneous Hybrid Revascularization by Carotid Stenting and Coronary Artery Bypass Grafting S.CAMILLO CLI ORD Brain Disorders and 16,75 200.000 Lombardia CLI ORD Vascular and 16,75 398.959 Hematology Lazio CLI ORD Surgical, Biomedical Imaging, and Bioengineering 17 0 2308645 Biotherapy of Colorectal Carcinoma by enhancing Lazio EST Oncology 2 17 0 HLA class II expression and cooperation with CD16+ myeloid cells in the CRC microenvironment 2318921 2318531 2312692 FUNCTIONAL EVALUATION OF HIP KNEE AND ANKLE ARTHROPLASTY FOR OSTEOARTHRITIS IN ELDERLY A NEW CARE MODEL TO MAINTAIN FUNCTION IN STROKE PATIENTS:EARLY THERAPEUTIC PATIENT EDUCATION AND LONG TERM GROUP PHYSICAL ACTIVITY(e TEAM2011 : early Therapeutic Education Associated with Movement) DO COC'S HAVE AN EFFECT ON PERITONEAL FLUID CYTOKINES?? RIZZOLI ORD Musculoskeletal, 17 150.000 Oral and Skin ARCISPEDALE CLI ORD Risk, Prevention 17 150.000 and Health Behavior Emilia Romagna CLI ORD Risk, Prevention 17 150.000 and Health Behavior Pagina 248 di 332

2321253 2313996 2315520 2321690 2317262 2314259 2301880 Gadoxetic acid (Gd EOB DTPA) enhanced magnetic resonance in the diagnosis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in cirrhotic patients: identification of diagnostic patterns and correlation with molecular transporters and histopat Protective ventilatory strategy in severe brain injured patients: a randomized control trial Assessment of Olfactory Function in Vegetative and Minimally Conscious State A Mathematical Model to optimize allocation of regional health care resource Frameless localisation technique for brain stereotactic radiotherapy MicroRNA expression profiling as biomarker for cutaneous melanomas Novel targets of cocaine and amphetamine influencing intercellular communication mechanisms Emilia Romagna CLI ORD Oncology 2 17 150.000 Piemonte CLI ORD Cardiovascular and 17 150.000 Respiratory NEUROLESI CLI ORD Brain Disorders and 17 154.500 NEUROLESI ORD Healthcare Delivery 17 155.500 and Methodologies Toscana CLI ORD Oncology 2 17 170.000 Sicilia ORD Oncology 1 Basic 17 175.000 S.CAMILLO ORD Brain Disorders and 17 194.000 2321481 Evaluation of Diagnostic Accuracy of DW and DCE Magnetic Resonance Imaging in the Mesorectal Nodes staging of Rectal Carcinoma ISTITUTO TUMORI MILANO ORD Surgical, Biomedical Imaging, and Bioengineering 17 200.000 2319832 Linguistic competence screening for dementia in patients with ischemic stroke. S.CAMILLO CLI EST Biobehavioral and 17 200.000 Behavioral Processes Pagina 249 di 332

2320517 2312548 2318255 2318704 Biomarkers of adverse neuropsychological outcomes in pre term newborns: Structural/functional connectivity Magnetic Resonance Imaging (MRI), Electroencephalography (EEG) and genetics Expression of markers associated with the main degradative pathways in fibroblasts derived from patients with sporadic or genetic Parkinson's disease: a study of susceptibility. Long term impact of an Atrial Fibrillation Unit on the management and on the outcome of patients with atrial fibrillation Development and validation of a simple and wearable new system for monitoring sleep and respiratory variables Abruzzo CLI EST Brain Disorders and 17 202.000 MONDINO ORD Molecular, Cellular, 17 210.000 and Developmental Liguria CLI ORD Cardiovascular and 17 215.000 Respiratory Toscana CLI ORD Bioengineering 17 220.000 and Technologies 2320264 Biochemical effects in ALS rehabilitation patients. S.CAMILLO CLI ORD Musculoskeletal, 17 240.000 Oral and Skin 2305731 2309103 2304917 2304042 Development of novel bisphosphonate entrapping liposomes to target macrophages: application in cancer prevention and therapy Hepatitis C virus (HCV) infection beyond the liver: bone and cardiovascular manifestations. Development of pharmacological strategies for the personalization of anti leukemic therapy for pediatric acute lymphoblastic leukemia Plasticity of facial emotional recognition and behavior in patients with Mobius Syndrome before and after surgical facial reanimation. GASLINI ORD Immunology 17 243.000 Sicilia CLI ORD Musculoskeletal, 17 250.000 Oral and Skin BURLO GAROFALO CLI ORD Oncology 2 17 250.000 Emilia Romagna ORD Integrative, Functional, and Cognitive 17 283.000 Pagina 250 di 332

2312299 2319660 2317006 2311128 2319261 First line chemotherapy with capecitabine vs regime xeloxiri (capecitabine, oxaliplatin and irinotecan) in elderly patients with locally advanced or metastatic cancer of the stomach or gastro esophageal junction: a phase II multicenter, randomized, open 2310814 2316787 New recreational drugs of abuse intoxication: prevalence estimation in the Emergency Departments referring to the Pavia Poison Centre The impact of depressive disorders on endothelial progenitor cells in patients with ischemic heart disease The BRCAness profile: from the molecular basis to the clinical relevance Genetics and molecular biomarkers of Food Allergy Cystic Lesions of the Pancreas: Creation of a Database and a New Evidence Based, Cost Effective Algorithm Guided bone regeneration with innovative degradable scaffolds MAUGERI CLI ORD Risk, Prevention 17 290.000 and Health Behavior Toscana ORD Cardiovascular and 17 300.000 Respiratory Toscana ORD Oncology 1 Basic 17 300.000 Toscana EST Genes, Genomes 17 300.000 and Genetics Lombardia CLI ORD Oncology 2 17 300.000 Sicilia CLI ORD Oncology 2 17 302.500 RIZZOLI ORD Musculoskeletal, 17 305.000 Oral and Skin 2319696 Hypertension in the pathogenesis of Leukoaraiosis: the role of Obstructive Sleep Apnea NEUROLESI CLI ORD Brain Disorders and 17 317.900 2305144 2316421 Cancer predictivity of biomarkers of exposure: an occupational based approach HIV 1 Nef protein affects opportunistic infections in human macrophages MAUGERI ORD Oncology 1 Basic 17 320.000 Istituto Superiore di Sanita' ORD AIDS and Related 17 333.333 Research Pagina 251 di 332

2320771 2316605 2313999 2312673 Impact Of Different Kras Mutations On Tumour Progression And Drug Sensitivity In Non Small Cell Lung Cancer Development of a miniaturized, automated assay for the diagnosis of rare diseases Biological foundations of self control and potential diagnostic implications Mechanisms of beneficial effects of physical exercise on healthy aging and neurological agerelated diseases Lombardia ORD Oncology 2 17 340.800 Piemonte COF Bioengineering 17 346.390 and Technologies Istituto Superiore di Sanita' ORD Biobehavioral and 17 361.000 Behavioral Processes MAUGERI ORD Biology of 17 400.000 Development and Aging 2315009 Bioengineering of TAVI Istituto Superiore di Sanita' EST Cardiovascular and 17 400.000 Respiratory 2316009 Oxidative stress in animals cancer stem cells: biological mechanisms involved in the pathogenesis of mammary spontaneous tumours Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Veterinary 17 410.000 2318861 significance and biomolecular characterization of VUS BRCA and analysis of phenotypic characteristics associated to BRCA1 5083del19 and 4843delC BRCA1 founder mutations in Sicilian patients with hereditary breast and ovarian cancer. Sicilia ORD Oncology 2 17 450.000 2313277 Engineering the microenvironment of implantable matrices to enhance the host response to tissue damages: a new regenerative medicine approach for wound healing IRCCS AOU San Martino IST (Genova) EST Cell Biology 17 450.000 2314311 Nutrient Signaling Pathways and Immune Response in the Sensitization of Neuroblastoma and Breast Cancer to Chemotherapy GASLINI EST Oncology 2 17 450.000 Pagina 252 di 332

2314927 Use and integration of clinical and administrative databanks to evaluate the quality and continuity of care processes for epidemiological study and for health planning for patients affected by heartbrain vascular diseases. Lombardia CLI ORD Healthcare Delivery 17 480.000 and Methodologies 2318578 2309161 2319747 2317958 2317431 2301927 2308025 2304431 Effectiveness of cognitive remediation in schizophrenia: a prospective, multicenter study in the "real world" setting of Italian psychiatric services Cancer stem cells as a model of carcinogenesis for head and neck squamous cell carcinoma: new technologies with potential to translate from the laboratory into the clinic. Health information systems to control for confounding in comparative outcome evaluation. Population study of disability health and ageing in Lombardia (DISHAL) The pathophysiological substrates of myoclonic syndromes: implementation of innovative multimodal functional approach and treatments From diet to cancer: an integrated approach to study the complex path from visceral fatassociated inflammation to colon cancer GENERATION OF HUMAN MONOCLONAL ANTIBODIES INTERFERING WITH HIV TRANSCYTOSIS FOR THE PREVENTION OF MUCOSAL INFECTION The Italian National Program on Surveillance of Antiretroviral Treatment in Pregnancy Lombardia CLI ORD Brain Disorders and 17 500.000 CROB EST Oncology 2 17 500.000 Lazio CLI ORD Healthcare Delivery 17 500.000 and Methodologies CARLO BESTA CLI ORD Population 17 532.998 and Epidemiology CARLO BESTA ORD Brain Disorders and 17 548.000 Istituto Superiore di Sanita' ORD Immunology 17 550.000 Istituto Superiore di Sanita' ORD AIDS and Related 17 562.000 Research Istituto Superiore di Sanita' ORD AIDS and Related 17 567.000 Research Pagina 253 di 332

2307784 2315120 2305722 2302685 2304912 New prognostic markers and therapies for Merkel cell carcinoma Platelet activation in type 2 diabetic patients with stable Coronary Artery Disease: insights into their thrombotic propensity using a Genome Wide approach. Post genomic approach to heart failure in diabetic patients Glycation/glycoxidation products in the pathogenesis of cardiovascular diseases: a search for new biomarkers of cardiovascular risk Genomic and Proteomic Biomarkers in Patients with Subarachnoid Hemorrhage SAN GALLICANO ORD Oncology 2 17 573.100 MONZINO ORD Vascular and 17 580.000 Hematology SAN DONATO CLI ORD Cardiovascular and 17 580.000 Respiratory Istituto Superiore di Sanita' ORD Cardiovascular and 17 583.000 Respiratory Sicilia EST Brain Disorders and 17 585.000 2316541 Risk assessment of arsenic exposure from ricebased food in children with celiac disease. Study of urinary metabolic profiles and genetic polymorphisms. OSPEDALE BAMBINO GESU' ORD Veterinary 17 591.200 2311814 Multimodal MRI in the degenerative brain diseases SANTA LUCIA CLI EST Brain Disorders and 17 594.000 2308134 2314406 Glycated haemoglobin and fasting blood glucose concentration: distribution, time trends and prediction of cardiovascular diseases in the Italian adult population Identification and characterization of "cancer stem cells/tumor initiating cells" in chronic lymphocytic leukemia Istituto Superiore di Sanita' ORD Population and Epidemiology 17 600.000 C.R.O. AVIANO ORD Oncology 1 Basic 17 600.000 Pagina 254 di 332

2313357 2315225 2316306 2310650 MULTI CENTER STUDY ON METABOLIC COMPLICATIONS IN HIV INFECTED PEDIATRIC PATIENTS BREAST CANCER RISK AND DIETARY MICRONUTRIENTS ASSOCIATED WITH ONE CARBON METABOLISM PATHWAY IN BRCA1/2 SUBJECTS: AN OBSERVATIONAL STUDY Prediction of patient specific total knee arthroplasty outputs: development of a validated patient specific numerical tool to predict contact mechanics and polyethylene stress Recruitment, computer assisted electroencephalographic analysis and functional evaluation in Encephalopathy with Status Epilepticus during Sleep/Continuous Spike and Waves during Sleep. Lombardia CLI ORD AIDS and Related 17,25 100.000 Research C.R.O. AVIANO ORD Population 17,25 180.400 and Epidemiology GALEAZZI ORD Bioengineering 17,25 250.000 and Technologies MONDINO CLI EST Brain Disorders and 17,25 394.000 2310978 Chromogranin A (CgA) in the diagnosis and monitoring of patients with gastro enteropancreatic (GEP) neuroendocrine tumors (NET): a single institution experience. MAGGIORE CLI ORD Oncology 2 17,5 150.000 2319301 2311763 2314178 Development and validation of a new urinary test for the detection of phosphoproteins in bladder cancer (BC) Determination of a therapeutic window of ontreatment platelet reactivity values in patients undergoing percutaneous coronary intervention to optimize both ischemic and bleeding adverse events. REGISTRY FOR HEREDITARY AND FAMILIAL BREAST CANCER AND IDENTIFICATION OF NEW DISEASE CAUSING GENES AND REGIONS Piemonte CLI ORD Oncology 2 17,5 175.000 MAUGERI ORD Cardiovascular and 17,5 190.000 Respiratory Lombardia CLI ORD Oncology 2 17,5 198.000 Pagina 255 di 332

2309927 2314561 2317165 2319108 2317962 2320386 The effectiveness of Individual Placement and Support (IPS) in clients with first episode of psychosis. Nanosize imaging with brain amyloid/tau targeted nanoparticles as an in vivo biomarker for Alzheimer s disease pathology High field MR evaluation in low level consciousness patients Effects of ambulatory oxygen on breathlessness, mobility and quality of life in patients with idiopathic pulmonary fibrosis Predicting recidivism of driving under the influence of alcohol and drug. A genetic, neuropsychological and evoked potential study. ReShape: Evaluation of determinants for cardiac remodeling after early mitral valve repair with annuloplasty using new computational tools Emilia Romagna CLI ORD Healthcare Delivery 17,5 200.000 and Methodologies Toscana ORD Surgical, Biomedical Imaging, and Bioengineering 17,5 218.000 NEUROLESI CLI ORD Brain Disorders and 17,5 225.000 Toscana CLI EST Cardiovascular and 17,5 250.000 Respiratory Veneto EST Biobehavioral and 17,5 250.000 Behavioral Processes MONZINO CLI ORD Surgical, Biomedical Imaging, and Bioengineering 17,5 284.000 2317056 An epizootiological survey of bats as reservoirs and vectors of emerging zoonotic viruses in Italy: implications for public health and biological conservation Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary 17,5 300.000 2310442 Andrological Screening and Reproductive Health in Young Adult Males Veneto CLI ORD Population 17,5 300.000 and Epidemiology 2321536 Identification of prevalence of urinary incontinence in breast cancer women in hormonal treatment. Identification of a diagnostic and therapeutic path. Toscana CLI ORD Healthcare Delivery 17,5 300.000 and Methodologies Pagina 256 di 332

2318492 2317981 2317126 Role of the combined ultrasonographic imaging and neurophysiological study for surgical treatment of peripheral nerves pathologies Downmodulation of CCR5 expression on T cells through maraviroc and its anti reservoir properties on a simian AIDS model NEW DIAGNOSTIC AND THERAPEUTIC APPROACHES FOR CONGENITAL DIARRHEAL DISORDERS Sicilia CLI ORD Surgical, Biomedical Imaging, and Bioengineering 17,5 300.000 Istituto Superiore di Sanita' ORD AIDS and Related 17,5 312.000 Research Lazio CLI ORD Digestive, Kidney 17,5 320.000 and Urological Systems 2315967 ROLE OF ENPP1 AND HSP70 SERUM LEVELS ON CARDIOVASCULAR DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS CASA SOLLIEVO SOFFERENZA ORD Vascular and 17,5 330.000 Hematology 2307550 2317953 2308381 2314052 2316271 DEVELOPMENT AND VALIDATION OF A NOVEL PROGNOSTIC SCORING SYSTEM FOR MYELOFIBROSIS BASED ON DEEP SEQUENCING MUTATIONAL ANALYSIS Evidence of preclinical Alzheimer s disease in healthy middle aged persons MARKERS OF PROGRESSION, INFLUENCE ON COGNITIVE IMPAIRMENT OCCURRENCE AND OXIDATIVE STRESS IN CAROTID ATHEROSCLEROSIS Transthyretin (TTR) amyloidosis: modulation of amyloidogenesis and neurotoxicity of three TTR variants. Immunological and virological predictors of HCV cure during therapy with the new direct acting antivirals (DAAs) Toscana ORD Oncology 2 17,5 340.000 FATEBENEFRATELLI ORD Brain Disorders and 17,5 350.000 Marche ORD Brain Disorders and 17,5 357.000 AUXOLOGICO ORD Brain Disorders and 17,5 358.000 Istituto Superiore di Sanita' ORD Immunology 17,5 360.000 Pagina 257 di 332

2309933 CREATION OF A LOGICAL BANK AND SEARCH FOR MARKERS OF DISEASE FROM THE POPULATION BASED REGIONAL REGISTRY OF PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS IN EMILIA ROMAGNA REGION Emilia Romagna CLI ORD Brain Disorders and 17,5 380.000 2309249 STUDY OF DIAGNOSTIC AND THERAPEUTIC INTERVENTIONS FOR ALLERGIC DISEASES IN LOMBARDY BY COST UTILITY ANALYSIS SAN RAFFAELE MONTE TABOR CLI ORD Healthcare Delivery 17,5 400.000 and Methodologies 2314084 2318029 2302040 2320893 Healthy diet: evaluation of antioxidant capacity of a weekly selected menu in elderly people, and factors affecting its strength. Fibrin resistance to lysis in pulmonary hypertension Inhibition of adrenal beta arrestin 1 signaling pathway as a new therapeutic target to counteract the adverse effects of heart failure related hyperaldosteronism MOLECULAR DISSECTION OF GENETIC AND CLINICAL VARIABILITY IN PRIMITIVE MYOCARDIAL DISEASES OF CHILDREN AND ADULTS BY BENCH TOP NGS SEQUENCER Emilia Romagna CLI ORD Healthcare Delivery and Methodologies 17,5 418.500 Toscana ORD Cardiovascular and 17,5 431.500 Respiratory MAUGERI ORD Cardiovascular and Respiratory 17,5 450.000 Lombardia ORD Cardiovascular and 17,5 450.000 Respiratory 2310058 HUNT FOR NEW DISEASE GENES IN STELLA MARIS EST Brain Disorders and 17,5 465.000 CONGENITAL MUSCULAR DYSTROPHY WITH HYPOGLYCOSYLATED ALPHA DYSTROGLYCAN 2318141 Oncological and Cardio oncological Chemoprevention: targets in the tumor microenvironment MULTIMEDICA ORD Oncology 1 Basic 17,5 495.000 Pagina 258 di 332

2319888 Study of three dimensional model analysis for evaluation of pelvic volume in patients with hemodynamic instability due to pelvic fracture. Emilia Romagna ORD Surgical, Biomedical Imaging, and Bioengineering 17,5 500.000 2306863 HEREDITARY EARLY ONSET ATAXIAS: DIAGNOSTIC PROTOCOLS AND THERAPEUTIC STRATEGIES OSPEDALE BAMBINO GESU' CLI EST Brain Disorders and 17,5 520.000 2308464 Leukocyte telomere length and risk of ischemic vascular disease in an Italian population. Molise CLI ORD Genes, Genomes 17,5 585.400 and Genetics 2316880 Biological markers of cancer stem cells Istituto Superiore di Sanita' ORD Oncology 1 Basic 17,5 590.000 2308105 2304348 2314305 2308339 2311287 2312857 RNA sequencing for the detection of progressive HPV lesions Mesenchymal stem cells and islet cotransplantation in diabetic rats: natural chemistry and physical Energy to improve graft revascularization and function by human adipose derived stem cells and biological markers in unipolar vs bipolar depression Molecular mechanisms, animal models and preclinical studies for validation of innovative target for pharmacological therapy of Huntington disease Neurofibromatosis: a spectrum of multifaceted disease The effects of different rehabilitation treatments on left unilateral neglect REGINA ELENA ORD Oncology 2 17,5 592.000 Emilia Romagna EST Endocrinology, Metabolism, Nutrition and Reproductive 17,5 600.000 FATEBENEFRATELLI EST Brain Disorders and 17,5 600.000 Istituto Superiore di Sanita' ORD Brain Disorders and 17,67 560.000 Emilia Romagna ORD Genes, Genomes 17,75 200.000 and Genetics S.CAMILLO CLI ORD Risk, Prevention 17,75 230.000 and Health Behavior Pagina 259 di 332

2313329 2311636 2307275 2312674 Analysis of HCV persistence in the host and its implications in virus related lymphomagenesis Gene expression profile and epigenetic regulation in human white adipose tissue Predictive markers of bone metastasis in primary breast tumors Study of the role of immune activation and immune senescence in the pathogenesis of atherosclerosis and bone metabolism disorders in HIV infected patients undergoing highly active antiretroviral therapy (HAART) Toscana ORD Oncology 1 Basic 17,75 396.000 AUXOLOGICO ORD Endocrinology, Metabolism, Nutrition and Reproductive 17,75 434.500 Emilia Romagna ORD Oncology 2 17,75 500.000 Lombardia CLI ORD AIDS and Related 18 135.420 Research 2308627 2310715 Effects of ALR administration, a physiological antiapoptotic and anti oxidative molecule, on Parkinson's Disease transgenic mice during the progression of the disease. DE BELLIS ORD Brain Disorders and 18 150.000 Genetic of Panic disorders BURLO GAROFALO ORD Genes, Genomes 18 150.000 and Genetics 2318587 2316115 Web based online follow up for patients with Amyotrophic Lateral Sclerosis Hypertension in childrenadolescents:predictors,risk factors and intra uterine growth retard Sicilia CLI ORD Brain Disorders and 18 150.000 Toscana CLI ORD Healthcare Delivery 18 158.000 and Methodologies 2319292 Making sense of safety in clinical critical settings Toscana CLI ORD Healthcare Delivery 18 160.000 and Methodologies Pagina 260 di 332

2317818 2310230 2314283 2319358 2321249 2316128 2308164 POST STROKE DYSPHAGIA:CLINICAL, COGNITIVE AND NEUROANATOMICAL CORRELATES Intensive nutritional counseling in cancer patients undergoing radiotherapy: a randomizedcontrolled trial. Identification of the mechanisms involved in the acquired resistance of human breast cancer cells to the dual EGFR/ErbB 2 tyrosine kinse inhibitor lapatinib Quantitative gait analysis in older adults with Alzheimer s disease and mild cognitive impairment: pathophysiological meaning and possible clinical applications Effect of brain inflammation on AMPA receptor modulation in Alzheimer s disease mouse model CORRELATION BETWEEN BREST ARTERIAL CALCIFICATIONS AT MAMMOGRAPHY AND CORONARY ARTERY CALCIUM SCORE IN ASYMPTOMATIC DIABETIC PATIENTS: TWO SCREENING IN ONE Learning by observation. As a cognitive process can be transformed into a powerful rehabilitation tool in intellectual disabilities. Lazio CLI EST Brain Disorders and 18 170.000 SAN MATTEO CLI COF Oncology 2 18 180.000 PASCALE ORD Oncology 2 18 183.600 Toscana CLI EST Brain Disorders and 18 199.000 FATEBENEFRATELLI ORD Molecular, Cellular, 18 200.000 and Developmental SAN DONATO CLI ORD Cardiovascular and 18 200.000 Respiratory SANTA LUCIA CLI ORD Biobehavioral and 18 200.000 Behavioral Processes 2319748 Magnetic resonance imaging based mid and longterm predictors of combined measures of clinical disability and cognitive impairment in patients with multiple sclerosis NEUROLESI CLI ORD Brain Disorders and 18 200.000 Pagina 261 di 332

2318560 2309980 2315183 2311477 2315786 2312772 2312854 2312358 2309188 Patterns of psychobiological functions in offspring of parents with Panic Disorder and Non Panic Anxiety Disorders: an high risk study. Biomarkers of clinical outcomes in stroke patients. Role of Alfa Melanocortin and Brain Derived Neurotrophic Factor polimorfisms in neurorehabilitation. Randomized controlled trial on the role of telemonitoring for the management of chronic obstructive pulmonary disease (COPD) CHILDREN AUGMENTED REHABILITATION AND ENABLING SPORT FOR SOCIABILITY Adenosine receptor imaging and function, and therapeutic targets in Chronic Heart Failure Novel high cost chemotherapies: clinical use, safety and efficacy after marketing approval in oncology practice Genetic polymorphism and bisphosphonaterelated osteonecrosis of the jaws: a case control study HOXB7/PBX dependent regulation of microrna 221/ 222 QUANTEC:QUantitative Analysis of Normal Tissue Effects in the Clinic.A Multicenter Italian prospective contribute to international research on radiation therapy damage,through a correlation between clinic,imaging,dosimetry and biology. Lombardia CLI ORD Risk, Prevention 18 200.200 and Health Behavior S.CAMILLO ORD Brain Disorders and 18 210.000 Sicilia CLI ORD Cardiovascular and 18 214.250 Respiratory SANTA LUCIA CLI ORD Brain Disorders and 18 215.000 Toscana CLI ORD Cardiovascular and 18 215.000 Respiratory Lombardia CLI ORD Oncology 2 18 220.000 Emilia Romagna EST Genes, Genomes 18 225.000 and Genetics Istituto Superiore di Sanita' ORD Oncology 1 Basic 18 240.000 Lombardia CLI ORD Oncology 2 18 246.000 Pagina 262 di 332

2318346 CORRELATIONS OF THE CLINICO NEUROPHYSIOLOGICAL FEATURES WITH THE HISTOPATHOLOGICAL FINDINGS AND microrna EXPRESSION IN DRUG RESISTANT TEMPORAL LOBE EPILEPSY Istituto Scienze Neurologiche ORD Brain Disorders and 18 250.000 2307294 Cranioplasty and rehabilitation for brain injured patients Emilia Romagna CLI ORD Brain Disorders and 18 250.000 2322067 Honey and other hive products free from pharmaceutical or environmental residues: innovative, automated honey bee farming system Istituto Zooprofilattico Sperimentale del Lazio e della Toscana COF Veterinary 18 260.000 2311594 research of the multi dimensional care model "MI PIACE PIACERMI" for childhood obesity treatment in ambulatory care setting and in patient treatment Liguria CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 18 264.395 2320860 Target Controlled Infusion Propofol compared with Midazolam plus Fentanyl for moderate sedation in Colonoscopy: a prospective, doubleblind randomized trial. SAN RAFFAELE MONTE TABOR CLI ORD Digestive, Kidney 18 270.600 and Urological Systems 2312227 Prospective evaluation of biological aging and immunesenescence in patients aged 70 years or more receiving adjuvant chemotherapy (CT) for early breast, lung and colo rectal cancer compared to age matched, non cancer patients Veneto CLI ORD Biology of 18 290.000 Development and Aging 2312271 CORONARY ATHEROSCLEROSIS IN THE YOUNG: EARLY DIAGNOSIS AND IDENTIFICATION OF RISK FACTORS FOR SUDDEN DEATH PREVENTION Veneto CLI ORD Cardiovascular and 18 290.000 Respiratory 2321761 In vitro and in vivo physiological cardiac remodelling in response to endurance and strength exercise training SAN RAFFAELE MONTE TABOR ORD Cardiovascular and 18 295.000 Respiratory Pagina 263 di 332

2319352 2313600 2314173 2313823 2315620 2309437 2314046 2317703 2316918 Association of all trans retinoic acid (ATRA) and trastuzumab for HER 2 positive metastatic breast cancer: a phase II evaluation of ATRA potential immuno modulatory activity for myeloid derived suppressor cells (MDSC). Next Generation Sequencing approaches for Diagnostics of common and rare genetic diseases InTeReSt Project. Integrated Tecnological Rehabilitation of Stroke. Upper limb rehabilitation: efficacy of robot versus neuromodulation treatment and assessment of adaptive central peripheral plasticity Effects of early microbiological diagnosis (molecular tests vs standard) on length of stay in Intensive Care Unit Evaluation of effect of PARP inhibitors with or without irradiation in preclinical models of softtissue sarcomas. functional Magnetic Resonance Imaging techniques: implementation, assessment and validation on the first Italian 7 Tesla Magnet Predictive biomarkers of response to chemoimmunotherapy in melanoma patients Primary prevention of Neural Tube Defects (NTD) by Inositol: the ASBI case control study Improving Quality of Life of Dialysis Patients. A Randomized Trial with a Psychological Intervention I. O. V. CLI ORD Oncology 2 18 298.000 NEUROMED CLI ORD Genes, Genomes 18 300.000 and Genetics DON GNOCCHI CLI COF Emerging Technologies and Training in s 18 300.000 Emilia Romagna CLI ORD Infectious Diseases 18 312.705 and Microbiology Toscana EST Oncology 2 18 345.000 STELLA MARIS ORD Surgical, Biomedical Imaging, and Bioengineering 18 350.000 Istituto Superiore di Sanita' ORD Oncology 2 18 350.000 Liguria CLI ORD Risk, Prevention 18 353.160 and Health Behavior Lombardia CLI ORD Biobehavioral and 18 374.000 Behavioral Processes Pagina 264 di 332

2316111 Role of PDGFR/CDCP1 pathway in TNBC aggressiveness ISTITUTO TUMORI MILANO ORD Oncology 2 18 382.800 2320953 Cytokine profile in ocular surface diseases and upper airways disorders: development of medical devices for ophthalmology and otorhinolaryngology use. Sicilia CLI ORD Interdisciplinary 18 390.000 Molecular and Training 2321118 Genotoxic effects related to pesticide exposure: a novel bio monitoring approach IRCCS AOU San Martino IST (Genova) ORD Population 18 400.000 and Epidemiology 2321778 2319202 2313068 2315337 2303445 2305274 Proteomics and transcriptomics studies to define a new role of REP1: insights in the molecular pathogenesis of Choroideremia Effectiveness and cost effectiveness of eating disorder networks in Italy microrna deregulation in atrial fibrillation: identification of pathogenetic mechanisms and of peripheral blood biomarkers Functional modifications of Substantia nigra pars reticulata neurons firing upon high frequency stimulation in the Subthalamic nucleus: a parallel investigation on Parkinson s disease patients treated with Deep Brain Stimulation and on rat midbrain slice Coronary arteriogenesis with combined pharmacological (dipyridamole and heparin) therapy Iron in cholangiocarcinoma: from understanding the role to possible development of novel treatments SDN ORD Cell Biology 18 400.000 Emilia Romagna CLI ORD Biobehavioral and 18 400.000 Behavioral Processes SAN DONATO CLI ORD Cardiovascular and 18 400.000 Respiratory SANTA LUCIA CLI ORD Brain Disorders and 18 400.000 Toscana CLI ORD Cardiovascular and 18 417.500 Respiratory HUMANITAS EST Oncology 1 Basic 18 420.700 Pagina 265 di 332

2312083 2315441 2315317 2317404 2321383 2321774 2318636 2319339 Immunosuppression and autophagy induced by rapamycin in combination with engraftment of BDNF secreting neural stem cells: a strategy for axonal regeneration and reduction of neuropathic pain in a mouse model of spinal cord injury. Effects of electronic cigarette smoking on preoperative smoking cessations and on post operative complications, functional recovery and quality of life before and after major lung resection for cancer Mesenchymal stem cells and T cells in head and neck squamous cell carcinoma: a unified vision of the tumoral stroma for the identification of new prognostic markers and possible therapeutical targets. Identification of new heart related mirnas as tools for diagnosis and terapy of heart malformations and diseases Development of algorithms for automatic classification of the ECG signals generated by equipment for telemedicine in order to validate diagnoses in cardiological emergency. TUMORIGENIC CELLS OF PANCREATIC CANCER. IN SITUIDENTIFICATION AND CLINICAL SIGNIFICANCE Evaluation of immune competence in naïve versus HAART treated HIV 1 infected individuals to optimize the clinical management Studies on antibodies in single chain format against the HPV16 E6, E7 oncoproteins as a novel therapeutic approach for HPV associated lesions. SANTA LUCIA ORD Brain Disorders and 18 430.000 HUMANITAS CLI ORD Risk, Prevention 18 433.000 and Health Behavior Toscana ORD Immunology 18 440.000 Emilia Romagna ORD Cardiovascular and 18 450.000 Respiratory Lombardia CLI ORD Cardiovascular and 18 450.000 Respiratory Lazio EST Interdisciplinary 18 475.000 Molecular and Training Istituto Superiore di Sanita' ORD AIDS and Related 18 480.000 Research Istituto Superiore di Sanita' EST Oncology 2 18 480.000 Pagina 266 di 332

2320254 2321764 2319304 Identification of novel functional and biological parameters to predict the response to cardiac resynchronization therapy Novel POCT device for sepsis diagnosis based on a multiassay optical biochip Reducing the costs associated to post stroke rehabilitation: a novel robot assisted treatment protocol SAN MATTEO CLI ORD Cardiovascular and 18 486.000 Respiratory Toscana ORD Bioengineering 18 500.000 and Technologies Veneto CLI ORD Emerging Technologies and Training in s 18 500.000 2312781 NETWORK BASED ANALYSIS OF HIGH GRADE SEROUS OVARIAN CANCER: COMPARISON OF PATHWAY ACTIVATION IN THE PRIMARY TUMOR AND MATCHED LOCAL RECURRENCE. ONCOLOGICO DI BARI ORD Oncology 1 Basic 18 520.000 2308398 Deployment of the trigger tools within the electronic medical record to enhance error detection in Neonatal Intensive Care Units (NICU): a cluster, randomized trial Lombardia CLI ORD Healthcare Delivery 18 525.000 and Methodologies 2313334 DONKEY S MILK DRINK/FOOD OF THE THIRD MILLENNIUM, A SICILIAN PROJECT TO RAISE AN OLD THERAPEUTIC PRODUCT. Istituto Zooprofilattico Sperimentale della Sicilia ORD Immunology 18 535.000 2321652 2311774 Extracellular nucleotides in myeloid leukemia: a role for inflammatory pathways in helping eradicate leukemic stem cells Biological endophenotype associated to the electroconvulsive therapy in major depression. Emilia Romagna ORD Oncology 2 18 540.000 FATEBENEFRATELLI ORD Brain Disorders and 18 541.750 2318479 Emerging technologies for genome manipulation, detection and characterization of West Nile virus strains Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise ORD Veterinary 18 570.000 Pagina 267 di 332

2318623 2318591 2317079 Cardiac stem cells for the treatment of cardiomyopathy induced by antineoplastic drugs IMPROVEMENT OF BREAST CANCER THERAPY BY USING NANOVECTOR DELIVERY SYSTEMS Development of functional nanoparticles for the inhibition of Mannose Binding Lectin, a novel target for stroke therapy MONZINO ORD Cardiovascular and 18 577.000 Respiratory Istituto Superiore di Sanita' ORD Oncology 2 18 585.000 Lombardia ORD Brain Disorders and 18 590.000 2314971 Neuroplasticity, rehabilitation and work ability Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro ORD Brain Disorders and 18 595.000 2316355 2318829 2317392 Continuity of CAre for severe chronic REspiratory patients (CARE) New nanotools for permeabilization of Brain Blood Barrier and early detection of Alzheimer disease New tools for individual risk assessment and treatment assignment in prostate cancer patients Puglia ORD Healthcare Delivery 18 600.000 and Methodologies NEUROMED ORD Emerging Technologies and Training in s 18 600.000 Istituto Superiore di Sanita' ORD Oncology 2 18 600.000 2303971 Human Mesenchymal Stem Cells as site regulated medicinal cells stimulating endogenous repair mechanisms in tissue injury IRCCS AOU San Martino IST (Genova) ORD Musculoskeletal, 18 600.000 Oral and Skin 2312509 Surgical aortic valve replacement versus transcatheter aortic valve implantation in patients 80 years and older at low surgical risk:the ELDERLY VALVE Trial SAN RAFFAELE MONTE TABOR CLI ORD Cardiovascular and 18 600.000 Respiratory 2319383 Four dimensions augmented reality navigation system for medical interventions CASA SOLLIEVO SOFFERENZA CLI ORD Surgical, Biomedical Imaging, and Bioengineering 18 600.000 Pagina 268 di 332

2319436 Human Autologous Cardiospheres For The Treatment Of Paediatric Heart Failure OSPEDALE BAMBINO GESU' CLI ORD Cardiovascular and 18 600.000 Respiratory 2310547 2320257 Cognitive rehabilitation after stroke: a randomized controlled trial to compare the efficacy of different protocols. Investigation of link between Lung Cancer Stem Cells (CSCs) and Epithelial Mesenchymal Transition (EMT) for tumour progression and metastatis Sicilia CLI ORD Brain Disorders and 18,25 150.000 PASCALE ORD Oncology 1 Basic 18,25 200.000 2317440 Predictive models of genito urinary and sexual dysfunction after high dose radiotherapy for prostate cancer ISTITUTO TUMORI MILANO CLI ORD Oncology 2 18,25 399.300 2312337 2309779 2319195 THE RELATIONSHIP BETWEEN BORDERLINE PERSONALITY DISORDER AND BIPOLAR DISORDER: A CLINICAL, MORPHOLOGIAL CEREBRAL AND LOGICAL COMPARISON STUDY OBESITY AND MALE HYPOGONADISM: WHO COMES FIRST? CHEMOTHERAPY BY SUPERSELECTIVE OPTHALMIC ARTERY INFUSION FOR THE TREATMENT OF INTRAOCULAR RETINOBLASTOMA FATEBENEFRATELLI ORD Brain Disorders and 18,25 600.000 SAN DONATO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 18,5 75.000 Toscana CLI ORD Oncology 2 18,5 175.000 2304418 Identification and biological characterization of individuals at risk for hereditary colorectal tumors Emilia Romagna ORD Genes, Genomes 18,5 180.000 and Genetics 2314895 THE ROLE OF EARLY SCREENING IN PERINATAL DEPRESSION Toscana CLI ORD Risk, Prevention 18,5 185.760 and Health Behavior Pagina 269 di 332

2305600 2321148 2309856 2306703 2314189 2321707 2314554 Role of hypoxia in glioblastoma metabolism. Looking for new therapeutic strategies to counteract tumor progression and recurrencies Correlation between morphologic alterations of the glomerular filtration barrier and variations of plasmatic and urinary levels of the brain derived neurotrophic factor (BDNF) in rats undergone repetitive transcranial magnetic stimulations (rtms) SAFETY AND EFFICACY OF LICENSED BONE MARROW DERIVED AND INTERFERON gamma PRE TREATED MESENCHYMAL STROMAL CELLS (MSCs) IN PATIENTS AFFECTED BY SEVERE, INTRACTABLE CHILDHOOD ONSET CROHN DISEASE AND JUVENILE IDIOPATHIC ARTHRITIS. A PIVOTAL TRIAL. Metabolic and cardiovascular risk in non obese and obese patients with obstructive sleep apnea: long term follow up Generation of protective immune regulatory environment in murine models of Multiple Sclerosis by CTLA4 Ig mediated tryptophan catabolism. Targeting NF kb to prevent inflammation and neuroplasticity impairment in Neurodegeneration Prediction of response to targeted therapies in esophageal adenocarcinoma patients using an endoscopic biopsies xenograft rat model. Abruzzo ORD Oncology 1 Basic 18,5 200.000 Istituto Superiore di Sanita' ORD Digestive, Kidney 18,5 200.000 and Urological Systems BURLO GAROFALO CLI ORD Immunology 18,5 200.000 Sicilia ORD Population 18,5 231.500 and Epidemiology Umbria ORD Immunology 18,5 250.000 FATEBENEFRATELLI ORD Brain Disorders and 18,5 250.000 I. O. V. CLI ORD Oncology 2 18,5 250.000 Pagina 270 di 332

2312335 Improving accuracy in cardiovascular disease risk prediction by metabolic markers in the Italian population Lombardia ORD Vascular and 18,5 270.000 Hematology 2319630 Strategies of psychological support in the context of clinical medical treatments aimed at preserving fertility in oncology, for women of childbearing age and girls of prepubertal age candidate for ovarian tissue banking. REGINA ELENA CLI ORD Risk, Prevention 18,5 300.000 and Health Behavior 2299167 2316973 A study of defensins and innate immunity genes in HPV infection and HPV related cancer and development of a rapid ELINOR test for HPV diagnosis. BEVO SIRCOPANOS (endocrine Benefits from Sicilian Extra Virgin Olive Oil, Sicilian Red wine and Consumption of Pesce Azzurro but No Smoking): a project by The Program of Molecular & Endocrinology and Women s Endocrine Health. BURLO GAROFALO CLI ORD Genes, Genomes 18,5 325.000 and Genetics Sicilia CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 18,5 350.000 2303042 early detection of cardiotoxicity in cancer patients ONCOLOGICO DI BARI CLI COF Cardiovascular and 18,5 350.000 Respiratory 2318061 2317661 2318551 2311593 A MULTIMODALITY APPROACH TO PREVENT THE NEUROLOGICAL DYSFUNCTION IN CARDIAC SURGERY Role of environmental factors on symptomatology in an experimental model of Parkinson s Disease Discovering Genetics of Intracranial Cerebral Heamorrhages (ICH) Optimising Natural Killer (NK) cell activation for liver anti fibrogenic immunotherapy. Veneto CLI ORD Brain Disorders and 18,5 370.600 SANTA LUCIA ORD Brain Disorders and 18,5 377.000 MONDINO ORD Brain Disorders and 18,5 400.000 SAN MATTEO ORD Immunology 18,5 400.000 Pagina 271 di 332

2321566 2318517 2311651 2318395 2321750 2309654 Randomized phase II study: treatment with BCG (Bacillus Calmette Guerin) versus Peptide Receptor Radionuclide Therapy (PRRT) in CIS (Carcinoma In Situ) G3 bladder tumor. ANTIOXIDANT PROTECTION IN HIV RELATED NEURODEGENERATIVE DISORDERS Epstein Barr virus infection and risk of developing autoimmune disease Systems biology approach to identify predictive biomarkers of B cell mediated rejection in paediatric kidney transplantation IDENTIFICATION OF GENETIC RISK FOR MELANOMA AND CANCERS OTHER THAN MELANOMA IN RELATIVES OF PATIENTS WITH CUTANEOUS MELANOMA A study to identify and validate predictive biomarkers for clinical outcome after oxaliplatinbased adjuvant chemotherapy (CT) in early stage colorectal cancer (ecrc) and bevacizumab based CT in metastatic colorectal cancer (mcrc) I.E.O. CLI ORD Oncology 2 18,5 444.000 Calabria ORD AIDS and Related 18,5 450.000 Research Istituto Superiore di Sanita' ORD Immunology 18,5 450.000 Veneto ORD Immunology 18,5 450.000 SAN MATTEO CLI ORD Oncology 1 Basic 18,5 450.000 HUMANITAS ORD Oncology 2 18,5 478.100 2306417 Role of leukocyte telomere length and CD34+ hematopoietic precursor telomerase activity in the pathogenesis of cellular senescence in diabetic nephropathy Emilia Romagna EST Digestive, Kidney 18,5 535.555 and Urological Systems 2315939 Biomarkers of ischemic damage and epileptogenesis in focal ischemic stroke models CARLO BESTA ORD Brain Disorders and 18,5 558.700 2316246 DESIGN OF NOVEL RATIONAL THERAPEUTIC STRATEGIES FOR RET DRIVEN MEDULLARY THYROID CARCINOMA ISTITUTO TUMORI MILANO ORD Oncology 1 Basic 18,5 567.600 Pagina 272 di 332

2318368 2316629 2315247 2311336 A gender specific approach to cardiovascular drug therapy Genetic and functional analysis of circulating micrornas in multiple sclerosis: potential prognostic biomarkers of disease course? Biomarkers for optimization of Attention Deficit Hyperactivity Disorder (ADHD) pharmacological therapy Deciphering the Transcriptional Signature of Sporadic Brain Arteriovenous Malformations: a Genome Wide Expression Study SAN RAFFAELE PISANA CLI ORD Cardiovascular and 18,5 575.000 Respiratory MAGGIORE EST Brain Disorders and 18,5 598.000 FATEBENEFRATELLI ORD Biobehavioral and 18,5 600.000 Behavioral Processes Istituto Superiore di Sanita' ORD Brain Disorders and 18,5 600.000 2306917 Congenital malformations in domestic ruminant calves in southern Italy: a study of the main genetic, toxicological and infective causes Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 18,5 600.000 2316738 2318535 2317895 Programmed cell death and the cross talk between the NF kb and the HIF signaling pathways: implications in hypoxia/ischemiaassociated brain injury Sleep and cardiovascular disturbances as biomarkers of dementia Cognitive changes associated with adjuvant chemotherapy (AC) in breast cancer: a FDG PET study NEUROLESI ORD Brain Disorders and 18,75 200.000 Toscana CLI ORD Brain Disorders and 18,75 205.000 Toscana CLI EST Brain Disorders and 18,75 255.000 2306342 Glutamate abnormalities in obsessive compulsive disorder: Neurobiology, Neuroimaging, and Genetics. SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 18,75 300.000 Pagina 273 di 332

2316793 Does adolescents perception of parental and peer drinking habits and lifestyle affect their approach to alcohol consumption? Molise CLI ORD Healthcare Delivery 18,75 383.000 and Methodologies 2308107 Towards controlling paratuberculosis in cattle throughmarker assisted or genomic selection Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta ORD Infectious Diseases 18,75 599.916 and Microbiology 2303174 2319786 2311214 2317260 2318994 Natural Chemistry and Physical Energy to Optimize Stem Cell Therapy of Vascular Diseases Emerging and Re emerging Viral Infections in the Tuscany Region The promise of HPCs and EPCs based therapies on vascular dysfunction in diabetes HOSPITAL PROCEDURES FOR ACUTE HEART FAILURE AND INTEGRATED COUNTRY/HOSPITAL CARE CELIAC DISEASE AND SMALL BOWEL MALIGNANCIES: A POSSIBLE ROLE OF CAPSULE ENDOSCOPY AND DOUBLE BALLOON ENTEROSCOPY FOR EARLY DIAGNOSIS IN HIGH RISK PATIENTS Emilia Romagna ORD Vascular and 18,75 600.000 Hematology Toscana ORD Infectious Diseases 18,83 400.000 and Microbiology Marche ORD Vascular and 19 150.000 Hematology Sicilia CLI ORD Cardiovascular and 19 150.000 Respiratory MAGGIORE CLI ORD Digestive, Kidney 19 151.200 and Urological Systems 2310032 Prenatal blood group characterization with noninvasive molecular methods for management and prevention of haemolytic disease of the foetus and newborn. Liguria CLI ORD Vascular and 19 185.000 Hematology 2313637 Role of comorbidities in COPD: focus on chronic kidney disease Sicilia CLI ORD Cardiovascular and 19 185.000 Respiratory Pagina 274 di 332

2306800 2311897 2317000 2312551 2299093 2315212 2304133 2319354 2318625 2317894 Technological advancement in deep brain stimulation surgery for Parkinsonian patients: use of neuronavigated frameless system AEQUITAS: Inequality and Quality of regional clinical pathways in diabetes management Advanced implementation of Cognitive Rehabilitation Programs (CRP) for Acquired brain injury (ABI): An integrative systems cares. High fidelity simulation based learning vs conventional education in cardiac arrest management Genetic response of colorectal carcinoma to chemotherapy to predict tumor response and circumvent chemoresistance MicroRNA signature in colorectal carcinoma: correlation with mutational status of signaling pathways and activity of anti EGFR treatments Quantitative Evaluation of Proprioceptive Acuity in 2D and 3D Environments StressAMI Remote multi disciplinary management program for outpatients with Coronary Heart Disease (CHD) after acute myocardial infarction (AMI) The early identification of the free radical disease of the newborn. New therapeutic strategies. Endogenous hydrogen sulphide (H2S) and airway inflammation of asthma Sicilia CLI ORD Brain Disorders and 19 200.000 Marche CLI ORD Population 19 200.000 and Epidemiology NEUROLESI CLI ORD Emerging Technologies and Training in s 19 205.000 Emilia Romagna CLI ORD Healthcare Delivery 19 210.000 and Methodologies Veneto ORD Oncology 2 19 240.000 PASCALE ORD Oncology 2 19 268.000 MAUGERI ORD Bioengineering 19 280.000 and Technologies AUXOLOGICO CLI ORD Healthcare Delivery 19 280.000 and Methodologies Toscana CLI ORD Healthcare Delivery 19 298.500 and Methodologies Piemonte ORD Cardiovascular and 19 300.000 Respiratory Pagina 275 di 332

2316641 Insulin Resistance and metabolic syndrome: predictive and prognostic implications in prostatic cancer patients PASCALE CLI ORD Oncology 2 19 300.000 2313797 2310156 Cheyne Stokes respiration in heart failure patients: from the identification of individual pathophysiological mechanisms to individualized treatment Impact of tobacco control policies and implementation of tobacco control interventions MAUGERI ORD Cardiovascular and Respiratory 19 318.000 Toscana ORD Risk, Prevention 19 350.000 and Health Behavior 2317679 Targeting Bacterial signal transduction to combat vancomycin resistant pathogens. Istituto Zooprofilattico Sperimentale della Sicilia ORD Infectious Diseases 19 350.000 and Microbiology 2302678 Host/Tumor Tailored Clock Chemotherapy: fighting cancer around the clock CASA SOLLIEVO SOFFERENZA ORD Oncology 1 Basic 19 350.000 2313911 Hypoxia, necrosis, NF kb activation and proinflammatory genes expression in mesothelioma progression. SAN RAFFAELE PISANA EST Oncology 1 Basic 19 350.000 2317521 Epidural Anesthesia in patients undergoing mitral valve surgery. A randomized controlled study with clinically relevant end points. SAN RAFFAELE MONTE TABOR CLI ORD Surgical, Biomedical Imaging, and Bioengineering 19 353.000 2312519 2318280 Molecular characterization of enteric viruses circulating in the infantile population in Sicily CLINICO PATHOLOGIC AND GENETIC STUDY OF THE PREDISPOSITION TO RENAL CANCER AND IDENTIFICATION OF DISEASE GENES IN PATIENTS AND FAMILIES WITH HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CANCER SYNDROME Sicilia ORD Infectious Diseases 19 365.000 and Microbiology Lazio CLI ORD Oncology 2 19 390.000 Pagina 276 di 332

2312892 Genetic determinants of heart failure (HF) Friuli Venezia Giulia ORD Cardiovascular and 19 400.000 Respiratory 2299888 2314390 Assessment of the role of image guided hypofractionated intensity modulated radiotherapy in the treatment of low and intermediate risk prostate cancer IGF PATHWAY IN NEUROENDOCRINE TUMORS: PROGNOSTIC ROLE AND NOVEL TARGET THERAPY Emilia Romagna CLI ORD Oncology 2 19 400.000 SDN CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 19 400.000 2315259 Autophagy inhibition in chronic myelogenous leukemia stem cells: the way to the cure? IRCCS AOU San Martino IST (Genova) ORD Vascular and 19 405.000 Hematology 2316658 2313678 2320879 Innovative approaches to assess the role of neutralizing and non neutralizing HIV specific antibodies in AIDS vaccine trials Can we promote beneficial neuroplasticity in the brain of mild cognitive impairment (MCI) and Alzheimer s disease (AD) subjects at their home or care home? TELEmedicine in Global management of aspects in patients with Obstructive sleep apnea (TELEGeCO) Istituto Superiore di Sanita' ORD AIDS and Related 19 420.000 Research SAN RAFFAELE PISANA CLI ORD Brain Disorders and 19 420.000 AUXOLOGICO CLI ORD Cardiovascular and 19 422.000 Respiratory 2313841 Metformin plus standard chemotherapy: a new weapon to target tumor initiating cells in colorectal cancer treatment and prevention ISTITUTO TUMORI MILANO ORD Oncology 2 19 433.000 2316114 Identification of metabolic and immunological parameters predictive for the risk of diseases or fertility problems in periparturient dairy cows Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche ORD Veterinary 19 450.000 Pagina 277 di 332

2302629 The personalized antidepressant therapy: from the genetic to clinical impact Provincia autonoma Bolzano ORD Emerging Technologies and Training in s 19 450.000 2319851 Psychotherapy and pharmacological interventions in Social Phobia: an fmri study on neurobiological correlates of treatment induced remission and of response predictors Toscana ORD Brain Disorders and 19 450.000 2313342 THE IMPACT OF EPIGENOMICS ON THE IDENTIFICATION OF NEW PROGNOSTIC MARKERS AND INNOVATIVE THERAPIES IN NEUROENDOCRINE TUMORS (NETs) AUXOLOGICO ORD Oncology 1 Basic 19 450.000 2314318 2313763 Role of type I IFN in dictating the immunogenicity of chemotherapy and in predicting the therapeutic efficacy of anticancer treatments Genome Wide Methylation Analysis on epigenome of test tube babies to evaluate whether Assisted Reproductive Technology is a safe practice. Istituto Superiore di Sanita' EST Oncology 2 19 450.000 AUXOLOGICO ORD Genes, Genomes 19 450.500 and Genetics 2310699 Molecular investigation and clinical relevance of RET expression in breast cancer GASLINI ORD Oncology 1 Basic 19 458.000 2315052 EXPERIMENTAL MODELLING OF TUMOR RELAPSE FOR THE DESIGN AND PRE CLINICAL VALIDATION OF COMBINATORIAL APPROACHES OF TARGETED THERAPY IN ORAL CAVITY CARCINOMAS Emilia Romagna ORD Oncology 2 19 490.000 2304870 A stem cell platform to identify adverse effects of toxicants: an integrated environmental analysis (food, air and water) MAUGERI ORD Cardiovascular and 19 500.000 Respiratory Pagina 278 di 332

2318452 2317731 2306456 2320575 Use of saliva as biological matrix for non invasive screening of oral cancer ONCOSAL (ONCOlogical Diagnosis by SALiva) Functional connectivity at rest as a tool to investigate the brain plasticity in acquired injured patients Next Generation Sequencing techniques open up new possibilities in the knowledge and diagnosis of hereditary arrhythmogenic diseases and prognostic evaluation of thoracic aortic aneurysms: integration between MRI indexes, biological and biomechanical properties CROB EST Oncology 2 19 500.000 SANTA LUCIA CLI ORD Brain Disorders and 19 500.000 Piemonte ORD Cardiovascular and 19 512.000 Respiratory Toscana ORD Cardiovascular and 19 550.000 Respiratory 2317762 Development of a Preclinical Model of Peritoneal Carcinomatosis with Cells from patients with Human Gastric Cancer SAN RAFFAELE MONTE TABOR ORD Oncology 1 Basic 19 550.000 2306771 Evaluation of the cognitive load and attention state of patients during neurorehabilitation, focusing on professional car drivers Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro CLI ORD Brain Disorders and 19 586.000 2312946 Experimental and clinical evaluation of the role of obesity and its treatment in determining and treating decompensation in chronic liver disease Emilia Romagna EST Digestive, Kidney 19 590.000 and Urological Systems 2320948 Dynamics of NF kb in Inflammation SAN RAFFAELE MONTE TABOR ORD Bioengineering 19 600.000 and Technologies 2320937 Development of predictive models based on clinical indicators, dosimetry and bioimaging to describe the dose effect due to laser treatment of skin cancer lesions SAN GALLICANO ORD Oncology 2 19 600.000 Pagina 279 di 332

2300607 2317318 2319831 2319248 2310617 2319003 2319520 2301188 Mediterranean Dietary to prevent conversion of Mild Cognitive Impairment to Alzheimer Disease: a randomized trial. A molecular approach to endometriosis: towards the prediction of the response to hormonal therapy. The neural substrate of transcranial direct current stimulation effects on memory functions in Alzheimer disease. A randomized, controlled study using neuropsychological, [18F]FDG PET and fast optical imaging evaluations. Neuroinflammation in cerebral ischemia: discerning the role of G protein beta/gamma complex translocation in reactive gliosis Study and application of innovative instrumentation and diagnostic protocols in the clinical electrophysiology of vision Role of physical exercise during adjuvant chemotherapy in patients with breast cancer in order to enhance endogenous cannabinoid and reduce nausea and depressive disorders: a randomized controlled trial A longitudinal study to evaluate personality and mood disorders in patients with Multiple sclerosis RNA silencing of the Gene for the Augmenter of Liver Regeneration in Hepatocarcinogenesis in vivo. CARLO BESTA CLI ORD Brain Disorders and 19 600.000 Emilia Romagna CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 19,25 150.000 Toscana CLI ORD Brain Disorders and 19,25 197.450 Sicilia EST Molecular, Cellular, 19,25 250.000 and Developmental Istituto Superiore di Sanita' EST Emerging Technologies and Training in s 19,25 350.000 Emilia Romagna CLI ORD Risk, Prevention 19,5 110.000 and Health Behavior SANTA LUCIA CLI ORD Brain Disorders and 19,5 120.000 DE BELLIS ORD Oncology 1 Basic 19,5 150.000 Pagina 280 di 332

2305989 2319052 2315743 Sudden sensorineural hearing loss: searching for new molecular markers. Oxidative stress and genetic susceptibility in Takotsubo Cardiomyopaty A training for dementia family caregivers to improve resilience and well being: a Sicilian perspective. Emilia Romagna ORD Vascular and Hematology 19,5 150.000 Sicilia CLI ORD Cardiovascular and 19,5 150.000 Respiratory NEUROLESI CLI ORD Healthcare Delivery 19,5 152.000 and Methodologies 2321294 The overexpression of ANGPTL4 is involved in the inhibition of proliferation of human gastric cancer cell line MKN 45. Study of the effects of ANGPTL4 in invasiveness and metastasis. Development of effective approach for cancer therapy. PASCALE COF Oncology 1 Basic 19,5 154.000 2305061 A web based intervention to educate patients with type 2 diabetes to healthy lifestyles Emilia Romagna CLI EST Endocrinology, Metabolism, Nutrition and Reproductive 19,5 180.000 2321712 PREVALENCE OF AMYLOIDOSES IN PATIENTS WITH MONOCLONAL GAMMOPATHY OF UNCERTAIN SIGNIFICANCE (MGUS) THROUGH UMORAL, ECHOCARDIOGRAPHICAL AND HYSTOPATHOLOGICAL SCREENING. ROLE OF PROTEOMIC ANALYSIS OF MINOR SALIVARY GLAND IN SYSTEMIC AMYLOIDOSES TYPING Lazio ORD Vascular and 19,5 220.000 Hematology 2307927 Enhancement of NKG2D ligands induced antitumor response in Hodgkin s lymphomas: ERp5 thiol isomerase and ADAM10 disintegrinmetalloproteinase as possible therapeutic targets. SAN RAFFAELE MONTE TABOR ORD Immunology 19,5 221.000 2314016 Transgenic zebrafish model to visualize proliferation in vivo. REGINA ELENA ORD Cell Biology 19,5 230.000 Pagina 281 di 332

2303758 2321161 2319919 2312865 2319645 2300612 2314612 2314722 Evaluation of the therapeutic role of mesenchimal stromal cells in a murine model of systemic lupus erythematosus. Renal cystic disease and ionic channels disease of the kidney: molecular diagnosis by next generation targeted sequencing Prevention of chronic kidney disease (CKD) progression by hypoxia inducible prolylhydroxylases (HIF PHs) inhibition: role of SIRT1 and autophagy Age related hearing loss: from gene identification to a better diagnosis and prevention HEART KIDNEY INTERACTIONS IN CHRONIC AND ACUTE DECOMPENSATED HEART FAILURE DERMATOLOGIC PROBLEMS IN ONCOLOGICAL PATIENTS. A PREVENTIVE AND THERAPEUTIC APPROACH Defective DNA polymerase beta isoforms as protective factors against Alzheimer's disease NEURAL BASIS OF FREE WILL AND VOLITIONAL INHIBITION IN PARKINSON S AND PHARMACORESISTANT EPILEPTIC PATIENTS Toscana ORD Immunology 19,5 240.000 Emilia Romagna ORD Genes, Genomes 19,5 243.000 and Genetics MAUGERI ORD Digestive, Kidney 19,5 250.000 and Urological Systems BURLO GAROFALO CLI ORD Genes, Genomes 19,5 255.000 and Genetics Emilia Romagna ORD Cardiovascular and 19,5 277.776 Respiratory SAN GALLICANO EST Musculoskeletal, 19,5 280.000 Oral and Skin OASI MARIA S.S. ORD Biology of 19,5 300.000 Development and Aging NEUROMED CLI EST Brain Disorders and 19,5 300.000 2319803 DIGITAL KIDS Emilia Romagna CLI ORD Healthcare Delivery 19,5 300.000 and Methodologies Pagina 282 di 332

2310757 2319659 2316842 PCA3,ADVANCED MAGNETIC RESONANCE IMAGING TECHNIQUES AND TISSUE AND CIRCULATING MOLECULAR MARKERS IN PROSTATE CANCER: DEFINING A NOVEL DIAGNOSTIC AND PROGNOSTIC ALGORITHM IMPEDANCEMETRY AND OPTICAL COHERENCE TOMOGRAPHY (OCT): NEW TECHNOLOGIES FOR NONINVASIVE ORAL DIAGNOSIS. A TRANSLATIONAL RESEARCH Assessment of falls risk among elderly populations: a multidimensional integrated approach to develop a reliable risk factor score for mass screening. PASCALE CLI ORD Oncology 2 19,5 300.000 Sicilia CLI ORD Musculoskeletal, 19,5 300.000 Oral and Skin SAN RAFFAELE PISANA CLI ORD Brain Disorders and 19,5 300.000 2315721 Molecular and in vivo analysis of in vitro generated cancer stem cell like cells: identification of pathways involved in CSC generation and maintenance MAUGERI ORD Oncology 1 Basic 19,5 305.000 2311474 2321773 2315872 2315660 PEPTIDE FROM PARIETARIA JUDAICA POLLEN WITH ANTI MICROBIAL ACTIVITY AS A NEW THERAPEUTICAL TOOL: EVALUATION OF INTERACTION WITH THE IMMUNE SYSTEM Traditional Chinese Medicine Herbal Drugs as Modulators of Multidrug Resistance in Cancer Cells Neutrophils in atherosclerosis contribute of sympathetic stress in the initiation and progression of disease from animal model to clinical manifestation Plasma mirnas as prognostic factors in patients with Chronic Lymphocytic Leukemia (CLL) Istituto Superiore di Sanita' ORD Immunology 19,5 357.000 Toscana EST Oncology 2 19,5 380.000 MAUGERI ORD Cardiovascular and 19,5 395.500 Respiratory ARCISPEDALE EST Oncology 2 19,5 400.000 Pagina 283 di 332

2310721 Language performance as clinical marker of progression from preclinical to overt dementia: multimodal neuroimaging and neuropsychological mechanisms SANTA LUCIA CLI ORD Brain Disorders and 19,5 450.000 2313662 Investigation on PPARs mediated effects of statins in renal and cardiovascular damage MONZINO ORD Cardiovascular and 19,5 484.600 Respiratory 2315255 Development of a DNA microarray for a rapid and reliable detection of pathogens in ready to eat foods. Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 19,5 500.000 2321765 Microvesicles as mediators of cell to cell interaction in hematological malignancies: biological characterization and clinical relevance in Chronic Lymphocytic Leukemia and Myelodysplastic Syndrome Piemonte ORD Oncology 2 19,5 500.000 2311578 Prevalence and risk factors of genital Chlamydia trachomatis infection among sexually active young women (15 24 years), in Italy Istituto Superiore di Sanita' CLI ORD Population 19,5 510.000 and Epidemiology 2318080 2312005 2312612 NEUROMUSCULAR ELECTRICAL STIMULATION AS A DRIVER OF NEURAL PLASTICITY IN THE CONTEXT OF POST STROKE REHABILITATION NCRpos Vd1 T cells: role of a newly disclosed gamma delta T cell subset in eradicatingtumors, in suppressing HIV 1 replication and in modulating the homeostasis of gut mucosalimmunity. New methods for Non ionizing imaging and guidance of ENDOvascular devices in CArdiac Surgery (NENDOCAS) FATEBENEFRATELLI ORD Brain Disorders and 19,5 550.000 HUMANITAS ORD Immunology 19,5 592.000 Puglia ORD Surgical, Biomedical Imaging, and Bioengineering 19,5 594.000 Pagina 284 di 332

2314611 Identification of immunological molecular patterns in atherosclerosis. SAN RAFFAELE PISANA ORD Vascular and 19,5 600.000 Hematology 2304279 PRE CLINICAL DEVELOPMENT OF A HUMAN Emilia Romagna ORD Immunology 19,5 600.000 MONOCLONAL ANTIBODY AGAINST FAS LIGAND FOR THE TREATMENT OF PEMPHIGUS 2308380 2319519 2318873 2321130 2321966 2321061 effect of different therapeutic approaches for thyroid related orbitopathy (Graves' orbitopathy) Role of chest physical examination to identifiy patients with early idiopathic pulmonary fibrosis: a multicenter prospective study FLEXIBLE FLATFOOT TREATMENT IN CHILDREN WITH MECHANICAL SOUND VIBRATION THERAPY Establishment of an Interdisciplinary Research Center for Parent/Patient Reported Outcomes in Pediatrics Micro RNA in patients treated with radiotherapy and/or surgery for high risk prostate cancer: a new molecular profile for prognosis and tailored treatment Old and new hypoglycemic agents and incidence of cancer in a large cohort of type 2 diabetic patients: the RIACE Study Lazio CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 20 0 Emilia Romagna CLI ORD Cardiovascular and 20 108.000 Respiratory Sicilia ORD Musculoskeletal, 20 150.000 Oral and Skin GASLINI CLI ORD Healthcare Delivery 20 150.000 and Methodologies Piemonte CLI ORD Oncology 2 20 150.000 Toscana CLI ORD Risk, Prevention 20 150.000 and Health Behavior 2308215 Determinants of FDG uptake in Hodgkin disease IRCCS AOU San Martino IST (Genova) CLI ORD Bioengineering 20 155.000 and Technologies Pagina 285 di 332

2316312 Relationship between sex hormones and cardiovascular risk: data from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS). Emilia Romagna CLI ORD Cardiovascular and 20 155.000 Respiratory 2316165 COCAINE CHEST PAIN Emilia Romagna CLI ORD Risk, Prevention 20 160.000 and Health Behavior 2320563 2319591 2321003 2321370 2311158 The unawareness of illness and executive dysfunctions in bipolaroutpatients Effect of intensive control of glycemia and associated cardiovascular ( CV ) risk factors on the evolution of severe psychiatric disorders. Intensive Remote Ischemic Conditioning for Effective Cardioprotection in Patients with STelevation Myocardial Infarction. IMPROVED PREDICTION OF ANTIVIRAL TREATMENT OUTCOME IN PATIENTS WITH CHRONIC HEPATITIS C VIRUS GENOTYPE 1 BY PRETREATMENT microrna PROFILING AND HEPATITIS C VIRUS MUTATION ANALYSIS Circulating markers predictors of response in patients with hepatocellular carcinoma (HCC) undergoing chemo embolization (TACE). Piemonte CLI ORD Brain Disorders and 20 160.500 Emilia Romagna CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 20 170.000 Toscana CLI ORD Cardiovascular and 20 177.825 Respiratory MAGGIORE ORD Digestive, Kidney 20 190.000 and Urological Systems Sicilia ORD Oncology 2 20 200.000 2319900 PHENOTYPE GENOTYPE CORRELATION IN PATIENTS AFFECTED BY HYPOGONADISM: IMPLICATIONS FOR CLINICAL MANAGEMENT. Toscana ORD Endocrinology, Metabolism, Nutrition and Reproductive 20 200.000 Pagina 286 di 332

2315036 Study on transmission patterns of Salmonella enterica serovar 4, 5, 12:i: within pig units Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche CLI ORD Veterinary 20 200.000 2314407 TESTING A MODEL FOR THE ASSESSMENT OF APPROPRIATENESS OF THE USE OF DRUGS, WITH ACTIONS TO SUPPORT HEALTH AND SOCIAL CARE TO FRAIL ELDERLY PEOPLE IN THE HOME VIA HOME DELIVERY OF THERAPY AND CONSEQUENT REDUCTION IN PHARMACEUTICAL EXPENDITURE WITHIN THE NA Marche CLI ORD Healthcare Delivery 20 200.000 and Methodologies 2314897 2320022 Vaccination strategies to prevent infections in splenectomized patients Action and object observation treatment in acute stroke patients SAN MATTEO CLI ORD Immunology 20 200.000 NEUROMED ORD Brain Disorders and 20 210.000 2313216 The relation between fine motor control and psychopathology in children: a general population twin study SAN RAFFAELE MONTE TABOR ORD Population 20 210.000 and Epidemiology 2322075 2320025 2318867 2320971 Benefits of cognitive training in healthy older adults after identification of risk factors for neurodegeneration Multidisciplinary Network for Chronic Pain Prevention. Interregional Model Multimodal approach to the presurgical evaluation of drug resistant epilepsy Biological characterization of Brain Tumor Initiating Cells and their treatment resistance features. MAGGIORE CLI ORD Biology of 20 210.000 Development and Aging SAN MATTEO CLI ORD Healthcare Delivery 20 250.000 and Methodologies S.CAMILLO CLI ORD Brain Disorders and 20 280.000 GASLINI ORD Oncology 1 Basic 20 288.120 Pagina 287 di 332

2320322 2309310 New gene variants in Long QT Syndrome using next generation sequencing systems Overcoming chemoresistance in adrenocortical cancer Emilia Romagna ORD Genes, Genomes 20 300.000 and Genetics Emilia Romagna ORD Oncology 2 20 300.000 2313356 Primary therapy with steroids and IVIG in Kawasaki disease OSPEDALE BAMBINO GESU' CLI ORD Vascular and 20 300.000 Hematology 2320750 2319355 Does rehabilitation of mirror neuron system improve brain rhythms and motor performance in dystonia patients? Low Level Laser Therapy for the treatment of radio and chemio induced oral mucositis SDN CLI ORD Brain Disorders and 20 300.000 Emilia Romagna CLI ORD Musculoskeletal, 20 300.000 Oral and Skin 2321336 THE ROLE OF 124 IODINE/CG250 PET IMAGING TECHNIQUE IN DETECTING LYMPH NODE METASTASES IN RENAL CELL CARCINOMA PATIENTS. SAN RAFFAELE MONTE TABOR CLI ORD Surgical, Biomedical Imaging, and Bioengineering 20 300.000 2319625 2315860 Neurodegenerative disorders and tumors: epidemiologic and genetic investigation on their relationship. Influence of genetic factors in the response and in the predisposition to side effects of dopamineagonists in patients with Idiophatic Parkinson Disease Sicilia CLI ORD Population 20 300.000 and Epidemiology NEUROLESI ORD Molecular, Cellular, 20 314.000 and Developmental 2312515 Analysis of immunogenicity of putative GPIanchored proteins of Babesia for vaccine and diagnostic purposes Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary 20 320.000 Pagina 288 di 332

2304622 2312397 2316036 2316372 2317358 2312124 PARP 1 and PARP 2 may have a differential role in supporting tumor cell growth: studies on the effects of selective subtype inhibitors in cell lines and in vivo. EARLY START EXERCISE TRAINING AFTER ACUTE DECOMPENSATION IN PATIENTS WITH CHRONIC HEART FAILURE: FEASIBILITY AND IMPACT ON FUNCTIONAL CAPACITY, NEUROHUMORAL ACTIVATION AND QUALITY OF LIFE. Bergamot Polyphenol Fraction as a treatment for metabolic syndrome and related cardiovascular complications: focus on mechanisms and bases of in vivo efficacy ROLE AND IMPACT OF DNA VIRUSES IN AUTOIMMUNE DISEASES Identification of molecular biomarkers to improve the preoperative diagnosis of follicular type thyroid cancer in the TIR3 cytologic stage as determined by classic FNA cytology Identification of new gender associated biomarkers in metabolic syndrome Toscana ORD Oncology 2 20 332.000 MAUGERI CLI ORD Cardiovascular and 20 350.000 Respiratory SAN RAFFAELE PISANA ORD Endocrinology, Metabolism, Nutrition and Reproductive 20 360.000 Emilia Romagna ORD Infectious Diseases 20 387.778 and Microbiology Emilia Romagna CLI ORD Oncology 2 20 400.000 Istituto Superiore di Sanita' CLI ORD Cardiovascular and 20 400.000 Respiratory 2311705 Perioperative markers of neurological and lung damage in infants with congenital heart diseases (CHD). A three years follow up study. OSPEDALE BAMBINO GESU' CLI ORD Cardiovascular and 20 400.000 Respiratory 2318692 Assessment of rehabilitation outcomes in eldery cancer survivors, compared to older patients without neoplasia, in order to establish a specific care model. DON GNOCCHI CLI ORD Oncology 2 20 403.000 Pagina 289 di 332

2317695 2318289 2313764 PROTEASE VARIABILITY IN PATIENTS INFECTED WITH HEPATITIS C VIRUS GENOTYPE 1: IMPLICATION FOR ANTIVIRAL TREATMENT USING DIRECTLY ACTING ANTIVIRALS (DAA) Antigen presentation defects and immunoevasion during colorectal cancer progression Does rehabilitation of mirror neuron system improve brain rhythms and motor performance in stroke and Parkinson s disease patients? Towards Internet based clinical applications at subjects home. Sicilia ORD Infectious Diseases 20 410.000 and Microbiology HUMANITAS EST Oncology 2 20 417.450 SAN RAFFAELE PISANA CLI ORD Brain Disorders and 20 420.000 2319216 Loss related pain as reflected by cortical responses to nociceptive stimuli in healthy subjects and individuals with complicated grief: perception, electrophysiology and a tentative pharmacological approach SANTA LUCIA EST Integrative, Functional, and Cognitive 20 440.000 2321766 2320317 Development of multi mycotoxins immunological methods for food and feed analysis Effect of Glucosamine and Vitamin D on Human Osteoarthritic Cartilage Istituto Superiore di Sanita' ORD Interdisciplinary 20 450.000 Molecular and Training RIZZOLI ORD Musculoskeletal, 20 450.000 Oral and Skin 2312860 INSTITUTION OF A REGIONAL MULTIDISCIPLINARY NETWORK FOR FERTILITY PRESERVATION IN CANCER SURVIVORS. CREATION AND IMPLEMENTATION OF AN INNOVATIVE ORGANIZATIONAL MODEL ISTITUTO TUMORI MILANO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 20 451.000 Pagina 290 di 332

2310750 2321901 CLINICAL, DIFFUSION TENSOR MAGNETIC RESONANCE IMAGING AND MOLECULAR STUDIES BY NEXT GENERATION SEQUENCING OF MIDLINE BRAIN DEFECTS ASSOCIATED WITH PITUTARY HORMONE DEFICIENCIES "mirna and protein expression profile in Colorectal cancer: analysis of their potential as screening, prognosis and therapeutic response biomarkers and as therapeutic targets?" GASLINI CLI ORD Genes, Genomes 20 461.940 and Genetics Piemonte EST Oncology 2 20 480.000 2317082 A comparison of reduced dose prasugrel and clopidogrel in elderly patients with acute coronary syndrome udergoing early PCI The elderly ACS 2 study Lombardia CLI ORD Cardiovascular and 20 490.000 Respiratory 2322018 Analysis of epidemiology and molecular characteristics of emerging salmonella serovars in Italy Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary 20 500.400 2309542 Modulation of the NAD salvage pathway as a novel pharmacological approach for spinal cord injury: a late preclinical study NEUROLESI ORD Brain Disorders and 20 545.600 2318413 Facing dourine challenge: improvement of diagnostic tools and investigation of pathogenic mechanisms Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise ORD Veterinary 20 570.000 2314339 2313556 Effects of robotic aided rehabilitation on the wrist joint in hemiparetic patients: an fmri study Physical activity as a strategic measure to reduce drugs consumption and interactions in elderly patients with cardiovascular disease and comorbidity Istituto Superiore di Sanita' CLI ORD Musculoskeletal, 20 573.100 Oral and Skin Molise CLI ORD Healthcare Delivery 20 580.000 and Methodologies Pagina 291 di 332

2305827 2313656 Evaluation of multi exposure to pesticides in a Sicilian population and biochemical correlates for in vitro induction of insulin resistance by cellular models. Human bronchial hyperresponsiveness in an exvivo model of hyperglycaemia MAUGERI ORD Endocrinology, Metabolism, Nutrition and Reproductive 20 585.000 SAN RAFFAELE PISANA ORD Cardiovascular and 20 590.000 Respiratory 2320770 Myocardial Fibrosis in Valvular Heart Disease Lazio CLI ORD Cardiovascular and 20 595.500 Respiratory 2313598 Differentiating Ehrlich carcinoma cells and reducing ascites in rats in vivo. A preclinical study. Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro ORD Oncology 1 Basic 20 600.000 2315455 2318980 Role of autophagy in the control of regulatory T cells and autoimmunity GABAergic modulation of resting state and stimulus induced activity within the default mode network: a translational investigation on depression. SANTA LUCIA ORD Immunology 20 600.000 SANTA LUCIA ORD Brain Disorders and 20 600.000 2307214 Eco epidemiology of M. bovis in a complex rural zoothenic system and identification of wild animals reservoirs Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary 20 600.000 2321234 2316037 MRI imaging of tumor associated macrophages in the early development of lung and bone metastasis Genetic contribution to acquired Long QT Syndrome in cancer patients receiving Tyrosine Kinase Inhibitors SAN RAFFAELE PISANA EST Oncology 2 20 600.000 MAUGERI CLI EST Oncology 2 20 600.000 2302783 Pharmacogenetics in Psychiatry: genetic susceptibility to psychotropic drugs metabolism CASA SOLLIEVO SOFFERENZA ORD Brain Disorders and 20,25 200.050 Pagina 292 di 332

2313613 Analysis of serotype, virulence factor diversity and antibiotic resistance pattern of E. coli strains isolated from ruminant and human samples in Sicily. Istituto Zooprofilattico Sperimentale della Sicilia ORD Infectious Diseases 20,25 425.000 and Microbiology 2309240 2314849 2308465 2321375 2310118 High risk preterm infants: an early diagnostictherapeutic intervention Laser Treatment of Haemophilic Hypertrophic Synovia Evaluation of tolerability and efficacy of sorafenib treatment in patients with hepatocellular carcinoma. Rehabilitation of visual spatial diseases in patients affected by cerebral lesion: a randomised controlled trial. ENVIROMENTAL ENRICHMENT AS A TREATMENT OF OBESITY IN CHILDREN AND ADOLESCENTS WITH INTELLECTUAL DISABILITY Piemonte CLI ORD Biobehavioral and 20,5 126.000 Behavioral Processes Toscana CLI COF Musculoskeletal, 20,5 150.000 Oral and Skin Sicilia CLI ORD Oncology 2 20,5 157.000 Emilia Romagna CLI ORD Brain Disorders and 20,5 176.918 STELLA MARIS CLI ORD Brain Disorders and 20,5 180.000 2320455 Transient Receptor Potential Canonical 1 (TRPC1) in pancreatic cancer: a new actor for NF kb inactivation CASA SOLLIEVO SOFFERENZA ORD Oncology 2 20,5 190.000 2300099 2321179 The challenge of lymphocyte resistance to drugs and Treg: developing selective approaches to target pathogenic lymphocytes in autoimmunity and GvHD New mechanisms of immune regulation performed by HLA G and characterization of its correlations with HLA E in different pathological conditions BURLO GAROFALO CLI ORD Immunology 20,5 190.000 Liguria ORD Immunology 20,5 190.360 Pagina 293 di 332

2321040 2321064 2301976 2318889 2319189 2316604 2306008 2318174 Beneficial impact of Caribbean dances and Mediterranean diet on patients with cardiovascular risk Identification of molecular and functional imaging predictors in response and toxicity to radio chemotherapy in head and neck cancers. Genetic and malformation risk associated with techniques of fertilization in vitro (IVF): a comparative prospective study of genetic and ultrasound analyses of fetuses conceived with IVF and spontaneously. Accuracy and clinical impact of 68 Ga labeled octreotide analogues PET in diagnosis and staging of duodeno pancreatic neuroendocrine tumours; proposal of a multicenter, prospective, non randomized clinical trial. Circulating micrornas as biomarkers of Atrial Fibrillation T AND B LYMPHOCYTES IN HEPATITIS B PATIENTS: ROLE IN ACUTE IN CHRONIC INFECTION. INNATE IMMUNE CELL RESPONSE TO HYPOXIC MICROENVIRONMENT: IDENTIFICATION OF POTENTIAL THERAPEUTIC TARGETS FOR JUVENILE IDIOPATHIC ARTHRITIS ECTODERMAL DYSPLASIA: EPIDEMIOLOGICAL, CLINICAL, GENETICAL STUDY AND PATIENTS NEEDS ANALYSIS. Puglia CLI ORD Cardiovascular and 20,5 250.000 Respiratory Toscana CLI ORD Oncology 2 20,5 250.000 BURLO GAROFALO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 20,5 265.000 ARCISPEDALE CLI ORD Surgical, Biomedical Imaging, and Bioengineering 20,5 284.104 MONZINO CLI EST Cardiovascular and 20,5 297.000 Respiratory Emilia Romagna ORD Immunology 20,5 304.000 GASLINI ORD Immunology 20,5 305.000 BURLO GAROFALO CLI ORD Population 20,5 332.200 and Epidemiology Pagina 294 di 332

2316430 2318569 2310870 2311781 2314748 2317975 Immunomodulatory effects of umbilical cord Wharton jelly derived human adult mesenchymal stem cells (hucms) on circulating Tc subsets of patients with systemic autoimmune disorders such as: 1) Type 1 diabetes mellitus (T1DM); 2) Connective tissue diseases Molecular pathology of colorectal carcinoma: basis for individual risk assessment and inherited cancer predisposition syndrome. A prospective study in consecutive patients enrolled in ULSS21. Cardiotoxicity from antracyclines and trastuzumab in the adjuvant treatment of breast cancer: early identification of high risk patients with a panel of biomarkers compared to traditional ecocardiographic evaluation. Integration of an inpatient clinical research in medical oncology within an intensity of care focused hospital (ICFH) model Vitiligo as model for autoinflammatory induced degenerative disease. Role of Phosphoinositide 3 kinase class II beta in platelet function and arterial thrombosis Umbria ORD Immunology 20,5 350.000 Veneto ORD Oncology 1 Basic 20,5 350.000 I. O. V. CLI ORD Oncology 2 20,5 360.000 Liguria CLI ORD Healthcare Delivery 20,5 380.500 and Methodologies SAN GALLICANO CLI EST Musculoskeletal, 20,5 400.000 Oral and Skin MULTIMEDICA ORD Vascular and 20,5 430.544 Hematology 2311170 Environmental and biological monitoring of exposure to traffic related air pollution for outdoor workers and evaluation of genotoxic and cardiovascular effects Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro ORD Population 20,5 500.000 and Epidemiology 2310404 Obesity as an intermediate phenotype of cardiovascular disease and cancer: in vivo and in vitro studies on tissue factor expression and related processes Molise ORD Vascular and 20,5 520.080 Hematology Pagina 295 di 332

2314871 BCL XL GENE EXPRESSION QUANTIFICATION FOR MINIMAL RESIDUAL DISEASE DETECTION IN PMF: A NEW MOLECULAR MARKER TO PREDICT EARLY RELAPSE IN JAK2V617F NEGATIVE PATIENTS. IRCCS AOU San Martino IST (Genova) ORD Oncology 2 20,75 225.000 2317474 2321822 2312156 New frontiers in breast imaging: contrast enhanced digital mammography. performance of contrast enhanced spectral mammography (CESM SenoBright) in presurgical evaluation of extent of malignancy in a population of women with breast cancer. Molecular characterization of Legionella pneumophila environmental strains as tool to Improve risk assessment analysis in hospital acquired Legionnaires disease Hepato protective and anti oxidant effects of silibinin in a rat model of non alcoholic fatty liver disease. I.E.O. CLI ORD Oncology 2 20,75 390.000 Istituto Superiore di Sanita' CLI ORD Infectious Diseases 21 0 and Microbiology Calabria ORD Endocrinology, Metabolism, Nutrition and Reproductive 21 100.000 2321917 Purification and utilization of adult adipose derived mesenchymal stem cells (ADMSC) from rat adipose tissue and their transdifferentation toward endothelial cells for kidney function recovery Istituto Zooprofilattico Sperimentale della Sicilia ORD Digestive, Kidney 21 150.000 and Urological Systems 2303051 Path to cure CML and Ph+ leukemias Emilia Romagna CLI ORD Oncology 2 21 150.000 2311290 Validation and improvement of an algorithm on the therapeutic treatment of vertebral metastases RIZZOLI CLI ORD Oncology 2 21 170.000 Pagina 296 di 332

2319083 EUS GUIDED CRYOTHERMOABLATION IN PATIENTS WITH UNRESECTABLE LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA: EFFICACY IN IMPROVING THE RATE OF RESECTABILITY AND REDUCING THE TUMORAL MASS. SAN RAFFAELE MONTE TABOR CLI ORD Oncology 2 21 175.000 2315648 Generic substitution of antidepressant drugs NEUROLESI CLI ORD Brain Disorders and 21 180.000 2310296 2314255 2307928 Mechanism of action of zoledronic acid in breast cancer Organized cervical cancer screening programs: evaluation of outcomes and identification of critical points, in Italian areas covered by Cancer Registries Functional and genetic study of innate immunity in early onset Inflammatory Bowel Disease. PASCALE ORD Oncology 2 21 184.000 C.R.O. AVIANO ORD Population 21 200.000 and Epidemiology BURLO GAROFALO CLI ORD Genes, Genomes 21 200.000 and Genetics 2314290 Unbalance of NGF receptor expression as a novel pathogenetic mechanism in inflammatory diseases: therapeutic potential of p75ntr inhibitors OSPEDALE BAMBINO GESU' ORD Immunology 21 203.000 2321641 DERIVATION AND VALIDATION OF A MODEL FOR MONITORING PATTERN OF CARE AND OUTCOME OF ACUTE CORONARY SYNDROME Emilia Romagna CLI ORD Healthcare Delivery 21 225.000 and Methodologies 2303143 Identification of a multi SNP profiling to predict metabolic syndrome in children OSPEDALE BAMBINO GESU' CLI ORD Genes, Genomes 21 225.000 and Genetics 2309620 Eradicating HIV from Infected Cells with a Trojan Integrase Emilia Romagna ORD AIDS and Related 21 240.000 Research Pagina 297 di 332

2309781 New genes CHI related: a lesson to understand mechanisms behind the insulin secretion. BURLO GAROFALO ORD Endocrinology, Metabolism, Nutrition and Reproductive 21 250.000 2319746 Implementation of an enhanced recovery after surgery program in different surgical specialties in multiple Italian institutions. SAN RAFFAELE MONTE TABOR CLI ORD Healthcare Delivery 21 268.000 and Methodologies 2314935 2316944 Disorders of consciousness: longitudinal Italian study on Vegetative State and Minimally Conscious State (ITADOCs) MOLECULAR ANALYSIS OF PRIMARY CUTANEOUS CD8+ AGGRESSIVE EPIDERMOTROPIC CYTOTOXIC T CELL LYMPHOMA CARLO BESTA CLI ORD Population and Epidemiology 21 296.555 MAGGIORE ORD Genes, Genomes 21 300.000 and Genetics 2321691 Development, Implementation and Evaluation of a Complex Program Focused on Quality of Life Assessment in the Palliative Care Network of the Ligurian Region IRCCS AOU San Martino IST (Genova) CLI ORD Healthcare Delivery 21 300.000 and Methodologies 2316451 2317776 New basic and clinical approaches to improve diagnosis and therapeutics strategies in extreme phenotypes of type 2 diabetic patients MICROBEAM STEREOTACTIC RADIOSURGICAL SUBTHALAMOTOMY AS A NEW SYMPTOMATIC TREATMENT FOR PARKINSON S DISEASE Piemonte EST Endocrinology, Metabolism, Nutrition and Reproductive 21 300.000 NEUROMED EST Brain Disorders and 21 300.000 Pagina 298 di 332

2322048 2319318 2318324 2320271 2311324 Title: Health care associated infections prevention and management of antimicrobial therapy through the development of a database and an artificial neural network: the microbiologist at the bedside. Sonochemotherapy. A new combined approach of sonoporation plus chemotherapy for the treatment of poorly chemosensitive cancers. Vitamin D supplements in geriatric major depression A NEW BANK FOR REGENERATIVE MEDICINE: MAY DISCARDED PLACENTA TISSUE BE UTILIZED? Study and control of anticipatory movements followed to adaptation of sequential learned motorial gestures related to subjects intensively trained: FMRI and DTMRI study Marche ORD Infectious Diseases 21 316.000 and Microbiology Emilia Romagna ORD Oncology 2 21 325.000 Emilia Romagna CLI ORD Brain Disorders and 21 340.000 Piemonte ORD Immunology 21 350.000 NEUROLESI COF Integrative, Functional, and Cognitive 21 360.000 2320318 ROLE OF GENE POLYMORPHISMS IN PREDICTING EFFICACY AND TOXICITY IN DIFFUSE LARGE B CELL LYMPHOMA PATIENTS TREATED WITH R CHOP IMMUNOCHEMOTHERAPY Toscana ORD Oncology 2 21 392.150 2320352 2314876 MOLECULAR CHARACTERIZATION OF BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM Synergistic anticancer effects of the ibraf, imek1/2 and ipi3k in melanoma and possible strategies to overcome the drug resistance MAGGIORE ORD Genes, Genomes 21 400.000 and Genetics PASCALE EST Oncology 2 21 400.000 Pagina 299 di 332

2317415 Impact assessment of Training Centre for Integrated Health Emergency Emilia Romagna CLI COF Healthcare Delivery 21 400.000 and Methodologies 2313099 Topoisomerase I from Leishmania infantum as potential chemotherapeutic target Istituto Zooprofilattico Sperimentale della Sicilia ORD Biological Chemistry and Macromolecular Biophysics 21 401.000 2319105 2318553 2317201 2319767 2311219 2317189 2307931 Prospective study to identify mechanisms of resistance to taxanes in breast cancer. Epigenetic alterations in nicotine and alcohol dependence New protocols for plasticity induction and motor recovery in stroke patients Protocol proposal about fixture abutment connection assessment by 3D microtomography analysis to avoid dental implant failure. Myo inositol: in vitro and in vivo study on sperm quality of oligo astheno teratozoospermia (OAT) patients The role of the urokinase/urokinase receptor (upa/upar) system in Inflammatory Bowel Disease (IBD) Innovative Tool for Uni compartmental Knee Prostheses & Evolution of Guidelines. Emilia Romagna ORD Oncology 2 21 420.000 Emilia Romagna ORD Brain Disorders and 21 440.000 FATEBENEFRATELLI ORD Brain Disorders and 21 506.000 Istituto Superiore di Sanita' ORD Bioengineering 21 511.000 and Technologies Istituto Superiore di Sanita' CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 21 520.000 HUMANITAS ORD Digestive, Kidney 21 600.000 and Urological Systems RIZZOLI ORD Surgical, Biomedical Imaging, and Bioengineering 21,25 545.000 Pagina 300 di 332

2313802 2319058 2307650 2314303 2304745 2311131 2320863 Development of minimally invasive techniques in treatment of skull base tumors. Anatomic and clinical study. Markers of gluten sensitivity in unipolar and bipolar disorders Role of PPAR (Peroxisome Proliferator Activated Receptors) alpha ligands in modulating allergeninduced inflammatory and dysfunctional alterations of the airways. ASSESSMENT OF THE PHYSIOPATHOLOGICAL MECHANISMS UNDERLYING GLIAL AND NEURONAL DAMAGE AND EVALUATION OF THE NEUROPROTECTIVE EFFECTS EXERTED BY RECOMBINANT ERYTHROPOIETIN AND OTHER TISSUE PROTECTIVE MEDIATORS. Cytokine secretion phenotype of airway immune cells in inflammatory and infectious diseases of the human lung Usher Syndorme: from the Italian epidemiology to the discover of novel related genes. INDIVIDUALIZING DURATION OF ANTITIC THERAPY IN HOSPITALIZED PATIENTS WITH COMMUNITY ACQUIRED PNEUMONIA Lazio CLI EST Surgical, Biomedical Imaging, and Bioengineering 21,5 0 Toscana CLI ORD Immunology 21,5 150.000 MAUGERI ORD Cardiovascular and 21,5 160.000 Respiratory Sicilia CLI EST Brain Disorders and 21,5 160.000 Toscana ORD Immunology 21,5 180.000 BURLO GAROFALO ORD Genes, Genomes 21,5 181.500 and Genetics MAGGIORE CLI ORD Infectious Diseases 21,5 205.000 and Microbiology 2321549 Eukaryotic translation Initiation Factor 4H /Wbscr1: its role in the aetiopathogenesis of the Williams Beuren Syndrome. SAN RAFFAELE MONTE TABOR ORD Brain Disorders and 21,5 210.000 2318607 relevance of detecting EpCAM+ tumour cells in peripheral blood and in bone marrow in patients with hepatocellular carcinoma Piemonte CLI ORD Digestive, Kidney 21,5 300.000 and Urological Systems Pagina 301 di 332

2319952 First international Inter Group Study for classical Hodgkin s Lymphoma in Children and Adolescents EuroNet PHL C1 Emilia Romagna CLI ORD Oncology 2 21,5 300.000 2316308 Why are MSCs therapeutic? MAGGIORE ORD Cell Biology 21,5 320.000 2314719 Project title: Safety and Effectiveness of H.E.L.P. apheresis in microcirculatory diseases refractory to standard care Emilia Romagna CLI COF Cardiovascular and 21,5 345.000 Respiratory 2317110 Development of a multiplex standard polymerase chain reaction assay for identification of infectious agents from aborted ruminants clinical samples Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 21,5 350.000 2314886 2318083 2320144 The ASAA study. Antibiotics vs. Surgery in Acute Appendicitis: an intention to treat prospective randomized controlled study Conservative and surgical care pathway in patients with neuromuscular scoliosis Major Depression in Systemic lupus erythematosus: a possible link between neurobiological aspects and biohumoral milieu Lombardia CLI ORD Surgical, Biomedical Imaging, and Bioengineering 21,5 380.000 RIZZOLI CLI ORD Musculoskeletal, 21,5 385.600 Oral and Skin Toscana ORD Brain Disorders and 21,5 400.000 2314369 Advanced magnetic resonance imaging in the study of multiple osteochondromas: correlations with genetic mapping, biochemical analysis and histology Istituto Scienze Neurologiche ORD Surgical, Biomedical Imaging, and Bioengineering 21,5 400.000 2320969 Impact of thrombophilia on risk of perinatal stroke in neonates: a prospective study OSPEDALE BAMBINO GESU' CLI ORD Vascular and 21,5 400.000 Hematology 2313142 Transcranial direct current stimulation in SCI rehabilitation: a translational study. Piemonte ORD Brain Disorders and 21,5 436.000 Pagina 302 di 332

2318586 2312254 Efficacy of Bone marrow concentrated cells(bmc) as scaffold for cellular differentiation in arthroscopic rotator cuff repair: A randomized controlled trial The role Inflammation and wound healing mechanisms in lung cancer biological behaviour and outcome prediction after surgical resection REGINA ELENA CLI ORD Musculoskeletal, 21,5 440.000 Oral and Skin HUMANITAS ORD Oncology 1 Basic 21,5 526.940 2319374 Development of an experimental biological protocol for the characterisation of new buccal and transbuccal dosage forms for localand systemic pharmacological therapies Istituto Zooprofilattico Sperimentale della Sicilia ORD Bioengineering 21,5 535.000 and Technologies 2317516 Gene Expression Profiles of the aneurysm wall and Genome wide screen in patients with Ruptured and Unruptured Intracranial Aneurysm: are there genetic determinants identifying Ruptured Aneurysm and patients at risk of rupture in Aneurysm Population? CARLO BESTA EST Vascular and 21,5 592.803 Hematology 2315659 Study of bacterial, parasitic and viral pathogens found in animal and vegetables food matrices, currently not covered by the national and European laws, with particular reference to the list of zoonotic agents. Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary 21,5 600.000 2313373 IMMUNE RESPONSE AND VDRS POLYMORPHISMS IN INFANTS AND CHILDREN EARLY SUPPLEMENTED WITH ORAL CHOLECALCIFEROL. Lombardia CLI ORD Immunology 22 120.000 2320043 The Avatar Bologna Project Emilia Romagna CLI ORD Risk, Prevention 22 150.000 and Health Behavior 2316826 Diabetes and neurocognition: the role of glycemic control and vascular comorbidities in elderly people with diabetes NEUROLESI CLI EST Biology of 22 162.000 Development and Aging Pagina 303 di 332

2315797 2321984 2313876 2311485 2313712 2314607 ezetimibe in patients Undergoing heart Surgical revascularization: the ZEUS Trial. Enhancing the efficacy and the efficiency of obesity treatment through the psicological assessment of obese patients. Imaging in clinical MR spectroscopy: reconstruction of high spatial resolution metabolic maps Smoking behavior in patients with established ischemic vascular disease from the Moli sani cohort study Learn and live: extended training for a safer hospital Pediatric headaches: utility of "RED FLAGS" in the use of CT and MRI Lazio CLI ORD Cardiovascular and 22 200.000 Respiratory Piemonte CLI ORD Risk, Prevention 22 210.000 and Health Behavior Toscana ORD Surgical, Biomedical Imaging, and Bioengineering 22 216.500 Molise ORD Population 22 223.850 and Epidemiology HUMANITAS CLI ORD Healthcare Delivery 22 233.500 and Methodologies Sicilia CLI ORD Healthcare Delivery 22 240.000 and Methodologies 2316196 mirna and vascular diseases: role of mir149, mir155, mir31, mir126, mir17 3p in endothelial dysfunction IRCCS AOU San Martino IST (Genova) ORD Vascular and 22 260.000 Hematology 2310092 In Vivo Detection of Cholangiocarcinoma at ERCP: Confocal Laser Endomicroscopy and Intraductal Aspiration. Sicilia CLI ORD Oncology 2 22 271.000 2312691 Antioxidants in metabolic syndrome SAN DONATO ORD Endocrinology, Metabolism, Nutrition and Reproductive 22 300.000 2316838 EARLY NEURAL CONNECTIVITY DEVELOPMENT: A PRENATAL FUNCTIONAL MAGNETIC RESONANCE IMAGING STUDY Veneto ORD Biology of 22 350.000 Development and Aging Pagina 304 di 332

2318213 2310303 2317112 2307248 2321468 2315992 2312864 2320943 2299663 The use of autologous adult, allogenic juvenile, and combined juvenile adult cartilage fragments for the repair of chondral defects. In vivo study on a goat model. Effects of sleep disturbances on the occurrence of post extubation respiratory failure and related mortality The efficacy of an HRV biofeedback training in patients with chronic Heart or Respiratory Failure Corrective cardiac surgery in utero: a new frontier for the management of the unborn child and for perinatal medicine Social dysfunction and social perception in schizophrenic patients and its relationship with symptom severity, assessed by behavioral and functional magnetic resonance studies. Phase II study to evaluate activity and toxicity of gemcitabine in combination with pemetrexed in long infusion in pretreated metastatic colorectal cancer patients Yin Yang 1 (YY1) overexpression in patients suffering osteosarcoma Assessment of left ventricular systolic and diastolic dysfunction in patients with pre clinical and overt heart failure. Study of a Novel RNA mediated Transcriptional Activation mechanism, Called RNA Memory as Therapeutic Stategy for Human Diseases. Piemonte ORD Musculoskeletal, 22 350.000 Oral and Skin Emilia Romagna CLI ORD Cardiovascular and 22 350.000 Respiratory MAUGERI CLI ORD Risk, Prevention 22 355.000 and Health Behavior Toscana ORD Cardiovascular and 22 380.200 Respiratory Abruzzo ORD Brain Disorders and 22 401.500 Emilia Romagna CLI ORD Oncology 2 22 410.000 SDN CLI ORD Oncology 2 22 450.000 (3) Sicilia CLI ORD Cardiovascular and 22 467.000 Respiratory Sicilia ORD Genes, Genomes 22 500.000 and Genetics Pagina 305 di 332

2319777 Clinic evaluation of Cervista(TM)HR HPV as Screening Test Abruzzo CLI ORD Interdisciplinary 22 550.000 Molecular and Training 2321860 Preclinical use of advanced magnetic resonance imaging and histopathology to improve diagnosis of neoplastic lesions in chronic hepatitis. SAN RAFFAELE MONTE TABOR ORD Surgical, Biomedical Imaging, and Bioengineering 22 580.000 2299090 2321834 2306575 Prognostic role of melanoma follow upa prospective randomised study Development of a new synthetic coronary bypass graft for coronary artery bypass grafting Pulmonary Rehabilitation in Lung Cancer surgical patients. I.E.O. CLI ORD Oncology 2 22 598.000 Toscana ORD Surgical, Biomedical Imaging, and Bioengineering 22 598.950 SAN RAFFAELE PISANA CLI ORD Cardiovascular and 22 599.000 Respiratory 2311990 Towards the understanding of the molecular bases of HIV latency SAN RAFFAELE MONTE TABOR ORD AIDS and Related 22 600.000 Research 2311791 2321368 2321920 Thyroid hormone treatment as a novel therapeutic strategy to prevent post ischemic cardiac remodeling TERAHERTZ SPECTROSCOPY AND IMAGING FOR DIAGNOSTICPURPOSES Vaccination with autologous dendritic cells loaded with autologous tumor lysate/homogenate combined or not with immunomodulating radiotherapy and/or preleukapheresis IFN alpha in patients with advanced melanoma: a randomized proof of principle phase II Toscana ORD Cardiovascular and 22 600.000 Respiratory Lazio ORD Surgical, Biomedical Imaging, and Bioengineering 22 600.000 Emilia Romagna CLI ORD Oncology 2 22 600.000 Pagina 306 di 332

2318332 Tubercolosis in neonates and infants: novel OSPEDALE BAMBINO approach to the diagnosis and to the management. GESU' CLI ORD Infectious Diseases 22,5 0 and Microbiology 2318795 2310790 2320112 2308849 2309397 2316537 2306780 2311744 New methods for diagnosis and prevention of potential celiac disease In vitro behaviour of bone cells under disuse simulating hypoxia conditions Evaluation of high frequency percussive ventilation on cystic fibrosis and other restrictive lung diseases Possible role of injured vascular cell derived microvesicles on pericyte vessel destabilization. Evaluation of candidate treatments for mevalonate kinase deficiency (MKD): pre clinical study on new cellular and animals models and biological features of multiple myeloma patients treated with new agents and presenting with extramedullary disease at diagnosis and at relapse. Observational prospective study of pulmonary ground glass nodules: meaning and efficacy of CAD detection for neoplastic patients. Identification of mechanisms of resistance to EGFR tyrosine kinase inhibitors in non small cell lung carcinoma (NSCLC) and monitoring the molecular evolution of lung tumors BURLO GAROFALO CLI ORD Digestive, Kidney 22,5 150.000 and Urological Systems RIZZOLI ORD Cell Biology 22,5 170.000 BURLO GAROFALO ORD Cardiovascular and 22,5 194.775 Respiratory Piemonte ORD Oncology 1 Basic 22,5 200.000 BURLO GAROFALO CLI ORD Immunology 22,5 200.000 Piemonte ORD Oncology 2 22,5 290.000 I. O. V. CLI ORD Oncology 2 22,5 300.000 PASCALE CLI ORD Oncology 2 22,5 330.000 Pagina 307 di 332

2300749 2314256 2319395 2320044 2320936 2309031 FUNCTIONAL AND STRUCTURAL EVALUATION OF CDKN2A UNCLASSIFIED VARIANTS (UVs) PREDISPOSING TO FAMILIAL MALIGNANT MELANOMA Neutrophil gelatinase associated lipocalin (NGAL) and Matrix metalloproteinase(mmp) 2 and MMP 9 as biomarkers of urothelial carcinoma development and progression Cognitive and neurophysiological markers of nonamnesic mild cognitive impairment (MCI) and dementia with Lewy bodies (DLB) Multi criteria decision approach (MCDA) to analyse priority setting decisions in the context of a transition from acute focused towards chronic care focused healthcare systems: implications for the Italian SSN Pharmacogenomics of clopidogrel in acute coronary syndromes. Adipose mesenchymal stem cells for the management of Crohn s disease fistulas I. O. V. ORD Oncology 1 Basic 22,5 345.000 C.R.O. AVIANO ORD Oncology 2 22,5 350.000 NEUROLESI ORD Brain Disorders and 22,5 550.000 Emilia Romagna CLI EST Healthcare Delivery 22,5 570.000 and Methodologies Emilia Romagna CLI ORD Cardiovascular and 22,75 300.000 Respiratory Lazio CLI ORD Surgical, Biomedical Imaging, and Bioengineering 23 55.000 2299263 Omic's in Blastocoele Emilia Romagna ORD Endocrinology, Metabolism, Nutrition and Reproductive 23 75.000 Pagina 308 di 332

2310495 2315190 2321647 2315563 Evaluation of the individual susceptibility through the analysis from "buccal swab" of genetic polymorphisms of phase 1 enzymes(cyps) and phase 2 (GSTs) in subjects exposed to benzene andethical aspects, liceity of genetic screening application in Obstructive sleep apnea syndrome and hypercoagulation Negative pressure therapy : model of Haealth management Hospital to territory Study of the activity of autonomic nervous system during sleep by means of pulse wave amplitude (PWA) variations detected by photopletismography. Istituto Superiore di Sanita' ORD Risk, Prevention 23 85.000 and Health Behavior SAN DONATO CLI ORD Cardiovascular and 23 150.000 Respiratory Veneto CLI ORD Surgical, Biomedical Imaging, and Bioengineering 23 150.000 Emilia Romagna ORD Emerging Technologies and Training in s 23 155.000 2314247 Molecular, immunological and clinical study on echinococcosis in natural and human hosts Istituto Zooprofilattico Sperimentale del Lazio e della Toscana ORD Infectious Diseases 23 200.000 and Microbiology 2321654 Impact of pioneering approaches to gait rehabilitation in Parkinson s disease: a controlled study of robot gait training and transcranial direct current stimulation effects Marche CLI ORD Brain Disorders and 23 200.000 2313019 Oxidative stress and fat profile in neuromuscular disorders with pediatric onset before and after a rationally modified dietary regimen. Istituto Scienze Neurologiche CLI ORD Brain Disorders and 23 220.000 2320649 Evaluation of triethylamine / triethylamine oxidized (TMA / TMAO) in patients with autosomal dominant familial hypercholesterolemia (ADH) Sicilia ORD Endocrinology, Metabolism, Nutrition and Reproductive 23 224.000 Pagina 309 di 332

2318291 2318670 2304015 2321155 2314050 Therapeutic potential of curcumin in ovarian cancer Asbestos dosage in biological tissues and fluids: standardization of sample preparation and analytical methods within National Health Service, Universities and Regional Environmental Protection Agencies laboratories. ESTABLISHMENT OF A SENIOR EMERGENCY ROOM FOR FRAIL ELDERLY AND PATIENTS WITH DEMENTIA Olfactory dysfunction: neurophysiological, neuropsychological and functional magnetic resonance assessment for the early detection of Alzheimer's disease. Role of insulin resistance in liver and gastrointestinal precancerous conditions development and evolution: cross sectional prevalence study and secondary prevention interventional strategies in Veneto Region high risk populations. Puglia ORD Oncology 2 23 240.000 Toscana ORD Population 23 250.000 and Epidemiology Emilia Romagna CLI ORD Healthcare Delivery 23 250.000 and Methodologies Toscana CLI ORD Brain Disorders and 23 250.000 I. O. V. CLI ORD Oncology 2 23 250.000 2320515 Obstructive sleep apnea as a cause of resistant hypertension: impact of CPAP treatment on blood pressure and number of antihypertensive medications SAN RAFFAELE MONTE TABOR CLI ORD Risk, Prevention 23 275.000 and Health Behavior 2319486 GENETIC FOCUSING IN SENSORINEURAL HEARING LOSS AND SPECIFIC LANGUAGE IMPAIRMENT IN SICILY Sicilia CLI ORD Brain Disorders and 23 287.000 Pagina 310 di 332

2316721 REHABILITATIVE APPROACH TO THE COGNITIVE DECLINE IN PARKINSON'S DISEASE: A CLINICAL AND FUNCTIONAL IMAGING STUDY Calabria CLI ORD Brain Disorders and 23 300.000 2321088 Effects of IL 7 administration in vivo on homing and tissue related distribution of T cells SAN RAFFAELE MONTE TABOR ORD AIDS and Related 23 325.000 Research 2318010 2307948 2313443 2309812 2318771 2318543 Role of mitochondria in ovarian cancer: diagnosis and prognosis BACKGROUND VALUES OF ESSENTIAL TRACE ELEMENTS, TOXICANTS AND THEIR METABOLITES IN THE ITALIAN GENERAL POPULATION Intrabone cord blood transplantation for hematological malignancies Characterization of a mouse model of creatine transporter deficiency:development of new therapeutic strategies for an untreatable inherited disorder of metabolism An Innovative Microchip based Deep Brain Stimulation Device for Improved Treatment and Rehabilitation of Parkinson s Patients Visual function in newborn at term and preterm at risk of brain damage: a new neonatal assessment visual european grid and correlations with neurodevelopmental outcome at short term (Naveg Project) Emilia Romagna ORD Oncology 1 Basic 23 339.595 MAUGERI ORD Population 23 400.000 and Epidemiology Emilia Romagna CLI ORD Vascular and 23 400.000 Hematology STELLA MARIS ORD Brain Disorders and 23 416.000 GALEAZZI ORD Brain Disorders and 23 431.000 MONDINO CLI ORD Integrative, Functional, and Cognitive 23 438.000 2320281 COMPREHENSIVE APPROACH TO THE TREATMENT OF ATRIAL FIBRILLATION: NEW MULTIDISCIPLINAR FLOW CHART FOR EARLY DIAGNOSIS AND EARLY TREATMENT SAN RAFFAELE MONTE TABOR CLI ORD Cardiovascular and 23 500.000 Respiratory Pagina 311 di 332

2318834 WIRVA Wireless control of Internal Routes and Vital signs monitoring for patients moving within hospital Areas Sicilia ORD Healthcare Delivery 23 559.000 and Methodologies 2317183 Metabolomic of newly diagnosed acute myeloid leukemia (AML) patients undergoing intensive treatment. SAN RAFFAELE MONTE TABOR ORD Oncology 2 23 560.000 2321506 The role of TRIM50 in the aggresome formation and clearance of polyubiquitinated and misfolded proteins: implications for Williams Beuren syndrome CASA SOLLIEVO SOFFERENZA ORD Cell Biology 23 571.000 2320873 2315571 2319043 2316834 Global prospective evaluation of the in vivo clinical efficacy and of the ex vivo bio mechanical properties of the biological meshes employed in thoracic abdominal pelvic wall reconstructive surgery. Echografic detection of Hepatocellular carcinoma with a 3 dimensional ultrasound with contrast media in cirrhotic patients. Neurobiological correlates of long term outcome predictors of Eating Disorders: a multidisciplinary approach using genetic polymorphisms analyses, fmri, and psychiatric assessment, repeated before and after a cognitive behavioural treatment. Wnt related proteins in the peripheral blood as potential predictors of response to lithium treatment in bipolar patients. Veneto ORD Surgical, Biomedical Imaging, and Bioengineering 23,25 0 Emilia Romagna CLI ORD Surgical, Biomedical Imaging, and Bioengineering 23,5 150.000 Toscana CLI ORD Brain Disorders and 23,5 175.000 NEUROMED ORD Brain Disorders and 23,5 225.000 Pagina 312 di 332

2316862 Activation of innate host defense mechanisms in multiple sclerosis: analysis of potential involvement of Toll Like Receptor (TLR)4, TLR9 and MyD88 adaptor using novel immunomodulatory compounds NEUROLESI ORD Immunology 23,5 254.600 2309520 Identification of molecular markers to determine NEUROMED ORD Oncology 2 23,5 260.000 new therapeutic strategies for Phase II Trials (GCP criteria) in patients with Glioblastomas 2320338 Development of methods to sub type Clostridium botulinum from animals to support epidemiological investigations and set up of a sera and vaccine bank for treatment and prevention of type C and D animal botulism Istituto Zooprofilattico Sperimentale delle Venezie ORD Veterinary 23,5 318.800 2312032 2320555 2318247 2319639 research in breast cancer metastases to the brain: a multidisciplinary approach to identify molecular pathways for the development of new therapeutic strategies CLINICAL PATHWAYS ON THE MANAGEMENT OF PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS IN DIFFERENT STAGES OF DISEASE ROLE OF DAMAGE ASSOCIATED MOLECULAR PATTERNS (DAMPs) IN EXACERBATING LUNG GRAFT ISCHEMIA REPERFUSION (IR) INJURY From new cancer drug registries to appropriateness of care and determinants of (regional) variability: implementing a new monitoring system to evaluate evidence based guidelines I.E.O. CLI ORD Oncology 2 23,5 340.300 SAN RAFFAELE PISANA CLI ORD Brain Disorders and 23,5 346.500 Lazio ORD Immunology 23,5 393.552 Emilia Romagna CLI ORD Oncology 2 23,5 428.000 Pagina 313 di 332

2309709 2319699 2316832 Environmental, food related (mycotoxins) and genetic basis of Neural Tube Defects susceptibility: prevention and treatment in Italian and Sudanese/Ethiopian populations. "Preventative strategies against dementia: clinical, biological and anthropological impact of longterm treatment with anti oxidants in mild cognitive impairment" HIGH FIELD STRENGTH MR SCANNERS (3 TESLA) TO DETECT MARKERS FOR EVALUATING DRUG RESISTANCE IN TEMPORAL LOBE EPILEPSY MEDEA ORD Brain Disorders and 23,5 600.000 Umbria CLI COF Brain Disorders and 23,75 150.000 Calabria CLI ORD Brain Disorders and 23,75 300.000 2318478 A multicentric case control study on Gastrointestinal (GI) microbiota, diet and immune system activation: effects of microbial modulation in healthy subjects and patients affected by Irritable Bowel Sydrome and Inflammatory Bowel Disease. Istituto Superiore di Sanita' ORD Infectious Diseases 23,75 308.000 and Microbiology 2320777 2311499 2319801 2315838 Impact of patient's and physician's gender on the prescriptions of cardiovascular and antidiabetic pharmacological agents in a community setting Systemic Treatment plus Radiofrequency Ablation versus systemic treatment alone in patients with non resectable colorectal liver metastases. TRAUMATIC BRAIN INJURY: A FAMILY PSYCHOLOGICAL INTERVENTION Small fields in radiotherapy: dose calibration and plan verifications for the modern, non standard treatment machines. Toscana CLI ORD Cardiovascular and 24 150.000 Respiratory Emilia Romagna CLI ORD Oncology 2 24 150.000 NEUROLESI CLI ORD Integrative, Functional, and Cognitive 24 152.000 Toscana CLI ORD Oncology 2 24 156.000 Pagina 314 di 332

2320360 2316835 2311518 2321805 Early detection of vascular complication in patients wit systemic sclerosis Development of innovative reference test phantom for quality assurance in advanced medical imaging. Effects of the prebiotic inulin in the treatment of chemotherapy induced mucositis and related alterations in gut microbiota IDENTIFICATION OF NEURODEVELOPMENTAL RISK FACTORS FROM GESTATION TO BIRTH: PRENATAL DIAGNOSIS OF NEUROLOGICAL DISEASE, MANAGEMENT IN NICU AND EARLY REHABILITATION CARE.ESTABLISHMENT OF A MULTIDISCIPLINARY DIAGNOSTIC AND THERAPEUTIC PATHWAY FOR THE NEWBO Sicilia CLI ORD Immunology 24 180.000 Toscana ORD Surgical, Biomedical Imaging, and Bioengineering 24 192.000 DE BELLIS ORD Oncology 2 24 200.000 Sicilia CLI ORD Brain Disorders and 24 200.000 2305180 Array CGH analysis of copy number variation (CNV) in patients with Hemophilia A: possible relationship with FVIII inhibitor development CASA SOLLIEVO SOFFERENZA ORD Genes, Genomes 24 233.000 and Genetics 2313154 2320910 A COMMON SCORE TO EVALUATE CLINICAL AND LOGICAL ASPECTS OF ACUTE MYELOID LEUKEMIA (AML) IN ELDERLY PATIENTS AIMED TO ENSURE HOMOGENEOUS DIAGNOSTIC AND TREATMENT CRITERIA IN THE HAEMATOLOGY UNITS IN EMILIA ROMAGNA. Unravelling the genetic defects in Maturity Onset Diabetes of the Young: a next generation sequencing approach Emilia Romagna CLI ORD Oncology 2 24 251.111 Emilia Romagna ORD Genes, Genomes 24 293.500 and Genetics Pagina 315 di 332

2317362 2317702 2321010 2312599 2320862 Bioethical issues in the use of the new criteria for Prodromal Alzheimer disease: disclosure of the diagnosis, clinical trials, social impact. Inflammation, angiogenesis and micrornas in malignant mesothelioma. Identification of high risk profiles in low HDL dyslipidemia Diagnosis and Management in Sicilian patients with Rare Diseases leading to Intellectual Disability: a Community evaluation and shared plan of improvement. Type 2 Diabetes Mellitus and Alzheimer's Disease: towards a common treatment? FATEBENEFRATELLI ORD Brain Disorders and 24 300.000 Toscana ORD Oncology 1 Basic 24 300.000 Toscana ORD Cardiovascular and 24 300.000 Respiratory OASI MARIA S.S. CLI ORD Healthcare Delivery 24 320.000 and Methodologies Piemonte CLI ORD Integrative, Functional, and Cognitive 24 420.000 2317244 2308509 SERIOUS GAMES IN VIRTUAL REALITY FOR THE EARLY DETECTION, MONITORING, AND MONDINO ORD Emerging Technologies and 24 440.000 REHABILITATION OF COGNITIVE IMPAIRMENT Training in s Optimization of diagnostic and clinical management of patients with combined chronic obstructive pulmonary and ischemic heart disease. MAUGERI CLI ORD Cardiovascular and 24 450.000 Respiratory 2316660 Identification in patients with gastric cancer of molecular events predictive of peritoneal carcinomatosis and of the response to heated intraperitoneal chemotherapy. SAN RAFFAELE MONTE TABOR CLI ORD Digestive, Kidney 24 505.000 and Urological Systems Pagina 316 di 332

2315146 2300719 2317980 2320487 2316547 CLINICAL AND LOGICAL INVESTIGATIONS IN PATIENTS WITH PRIMARY PLASMA CELL LEUKEMIA RECEIVING A TRIPLE COMBINATION OF BORTEZOMIB, LENALIDOMIDE AND DEXAMETHASONE AS FIRST LINE TREATMENT Virus host interaction in Influenza A and Hepacivirus infections: ecological and molecular studies B cell specific nanoparticles as a vehicle for innovative in vivo drug delivery in p53 dependent chemoresistant chronic lymphocytic leukemia Epitope mapping of Pru p 3 with multiple antigen or linear peptides: new approaches for the diagnosis and follow up of patients with severe IgE mediated reactions to food MARKERS OF ENDOTHELIAL PROLIFERATION IN BREAST AND COLORECTAL CANCERS: A NEW PROSPECTIVE FOR TARGET THERAPY. CROB CLI ORD Oncology 2 24 520.000 Istituto Superiore di Sanita' ORD Veterinary 24 580.000 C.R.O. AVIANO ORD Oncology 2 24 600.000 Toscana ORD Immunology 24,5 150.000 Sicilia CLI ORD Oncology 2 24,5 160.000 2318387 Optimization of the number of fractions in hypofractionated external beam radiation therapy: suggestions from fitting a reoxygenationincluding TCP model to in vivo and to clinical data. Veneto ORD Oncology 2 24,5 180.000 2319771 Molecular profiling of squamous cell carcinomas of the head and neck: evaluation of diagnostic, prognostic and therapeutic implications Istituto Superiore di Sanita' ORD Oncology 2 24,5 220.000 2313766 Oxidative stress and apoptosis defects in naive Kawasaki disease patients OSPEDALE BAMBINO GESU' CLI ORD Vascular and 24,5 300.000 Hematology Pagina 317 di 332

2321873 Development of an expert system software for reporting antimicrobial resistance assays results through a decision making process and management of antimicrobial resistance data. Istituto Zooprofilattico Sperimentale della Sardegna CLI ORD Veterinary 24,5 330.000 2321575 IntraOperative Imaging Technologies (IOIT): supporting decision making process in the Italian National Health Care System (NHS) Agenzia per i Servizi Sanitari Regionali CLI ORD Surgical, Biomedical Imaging, and Bioengineering 24,5 353.792 2321043 2316799 2311105 2315201 2304062 Targeting MicroRNA profile in cancer associated angiogenesis: new therapeutical and prognostic tools. Characterization of extrapyramidal features in mitochondrial disorders Efficacy and safety of early and intensive rehabilitative interventions in patients with stroke. A randomized controlled trial Pathogenicity, virulence and antibiotic resistance mechanisms of Multi Drug Resistant (MDR) Gram negative bacteria: impact on Rehabilithation Facility patients and on infection control strategies. THE SIGNATURE OF TRANSCRIPTION FACTORS INVOLVED IN AGGRESSIVE OVARIAN CANCER Abruzzo ORD Oncology 2 24,5 360.000 S.CAMILLO CLI ORD Brain Disorders and 24,5 360.000 SANTA LUCIA CLI ORD Brain Disorders and 24,5 406.000 MAUGERI ORD Infectious Diseases 24,5 446.964 and Microbiology Molise ORD Oncology 2 24,5 450.000 2315022 A RANDOMIZED CONTROLLED TRIAL TO EVALUATE THE EFFECTIVENESS OF AN INTEGRATE TRAINING IN PRIMARY CAREGIVERS AND IMMIGRANT PAID CAREGIVERS WHO CARE FOR PATIENTS WITH DEMENTIA FATEBENEFRATELLI CLI ORD Healthcare Delivery 24,5 450.000 and Methodologies Pagina 318 di 332

2313747 Study on relation between protein aggregation and mitochondrial dysfunction: an effort to find new targets for the diagnosis and therapy of neurodegenerative deseases. Istituto Zooprofilattico Sperimentale della Sicilia ORD Brain Disorders and 24,5 468.800 2317579 2322035 Effects of different radiation schedules on an immortalized human neural progenitor cell line grown as monolayers or spheroids. DETECTION OF C KIT ; BRAF AND N RAS MUTATION IN NAIL MELANOMA Emilia Romagna ORD Oncology 2 24,5 500.000 Emilia Romagna ORD Genes, Genomes 24,5 508.000 and Genetics 2315776 Antimicrobial resistance and Zoonoses in Wildlife: Emerging Issues. Istituto Zooprofilattico Sperimentale del Mezzogiorno ORD Veterinary 24,5 600.000 2316794 2321555 2317947 2318363 Optimizing the combined use of electrical stimulation and dopaminergic drugs in temporal and spatial aspects of action neuro rehabilitation DETECTION OF ASYMPTOMATIC LEFT VENTRICULAR DYSFUNCTION IN A POPULATION OF OBESE SUBJECTS. THE ROLE OF NATRIURETIC PEPTIDE AND ECHOCARDIOGRAPHY: STUDIO PROBE OBESITY Application of digital images acquired by computed tomographyand magnetic resonance in forensic medicine: virtual autopsy Ex vivo generation of human red blood cells from umbilical cord stem cells Lazio CLI EST Brain Disorders and 24,75 276.000 Toscana CLI ORD Cardiovascular and 25 150.000 Respiratory NEUROLESI CLI ORD Surgical, Biomedical Imaging, and Bioengineering 25 190.000 Emilia Romagna ORD Vascular and 25 200.000 Hematology Pagina 319 di 332

2312768 Endoscopic treatment of obesity and type 2 diabetes by endoluminal device (Endobarrier): a prospective study SAN RAFFAELE MONTE TABOR CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 25 244.750 2312444 2321776 2319252 2308664 2313049 2317897 2309601 2317575 In vitro and in vivo evaluation of the mechanisms of NK cells interaction with Acute Myeloid Leukemia cells. Role of peritoneal dialysis in the treatment of refractory heart failure Pain in post surgical hip and knee rehabilitation: occurrence, influence and basis for development and testing of a reasoned pain free therapeutic algorithm. MECOLECULAR PROFILING OF NORMAL AND CANCER HUMAN PROSTATE STEM CELLS Developing Gold Nanoparticles for detection of circulating tumor cells in early diagnosed breast cancer patients Cognitive stimulation versus music therapy in patients with cognitive impairment secondary to multiple sclerosis or brain tumor Cluster randomized trial to assess the effectiveness of a population based educational campaign on stroke symptom recognition in reducing pre hospital delay. Characterization of molecular pathways predicting the responsiveness to multikinase inhibitors in renal cancer. Emilia Romagna ORD Immunology 25 250.000 Puglia CLI ORD Cardiovascular and 25 250.000 Respiratory DON GNOCCHI CLI ORD Musculoskeletal, 25 291.000 Oral and Skin Sicilia ORD Oncology 1 Basic 25 322.400 MAUGERI ORD Biological Chemistry and Macromolecular Biophysics 25 380.000 CARLO BESTA CLI ORD Brain Disorders and 25 394.000 Emilia Romagna CLI ORD Healthcare Delivery 25 405.245 and Methodologies Veneto ORD Genes, Genomes 25 447.000 and Genetics Pagina 320 di 332

2319347 2313246 2321233 2317582 2316647 Modeling neurodegenerative disease in mice by overexpression of beta catenin in T cells: toward discovery of the novel mechanisms and therapies for amyotrophic lateral sclerosis CLINICAL AND SOCIAL GOVERNANCE OF MIGRANTS OF MEDITERRANEAN Governance: New Healthcare Delivery Performance Scorecard THE GENETICS OF THE INTERPLAY BETWEEN PRO SURVIVING AND REGULATOR OF THE GLUTAMATERGIC SYSTEM AS A BASIS OF ANTIDEPRESSANT RESPONSE Affective symptoms dimensions and treatment outcome in unipolar and bipolar depression. NEUROLESI ORD Brain Disorders and 25 540.000 Sicilia CLI ORD Healthcare Delivery 25 550.000 and Methodologies Molise CLI ORD Healthcare Delivery 25 570.000 and Methodologies Emilia Romagna ORD Genes, Genomes 25 600.000 and Genetics Sicilia CLI ORD Brain Disorders and 25,5 150.000 2315286 The role of oxytocin in anxiety disorders FATEBENEFRATELLI ORD Brain Disorders and 25,5 194.000 2307352 2314253 2312469 ESTABLISHING THE IN VIVO THRESHOLD FOR AMYLOID DEPOSITION IN PRODROMAL TYPICAL AND ATYPICAL ALZHEIMER DISEASE T cell Lymphoblastic Lymphoma and T cell Acute Lymphoblastic Leukemia: NOTCH1 alterations as a new target for an innovative treatment strategy DNA Bank in IRCCS San Donato Group to Study the Correlation between Genotypic and Phenotypic Pictures in the Metabolic Syndrome and in Type 2 Diabetes Toscana CLI ORD Brain Disorders and 25,5 196.000 Emilia Romagna CLI ORD Oncology 2 25,5 200.000 SAN DONATO CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 25,5 300.000 Pagina 321 di 332

2314720 2316489 IATRIS neuroscience: a critical reassessment of preclinical studies in neurologic diseases. Expression and functions of Toll like receptors in pediatirc acute leukemia cells and leukemia initiating cells Istituto Superiore di Sanita' ORD Brain Disorders and 25,5 365.000 GASLINI ORD Immunology 25,5 580.000 2313136 Taxi Doctor SAN RAFFAELE MONTE TABOR CLI ORD Healthcare Delivery 25,75 214.444 and Methodologies 2316006 2319242 2320530 2300809 Is there a causal relationship among serum ADMA levels, IMT, white matter hyperintesities and executive dysfunction? A Cross sectional study The Rorschach Test as a neuropsychological assessment tool Evaluation of Magnetic and Electromagnetic Fields Exposure for Workers in Magnetic Resonance Environments CPAP (CONTINUOUS POSITIVE AIRWAY PRESSURE) FOR SLEEP DISORDERS IN CHRONIC HEART FAILURE NEUROLESI CLI ORD Brain Disorders and 26 151.000 NEUROLESI CLI ORD Brain Disorders and 26 152.500 NEUROLESI ORD Healthcare Delivery 26 256.000 and Methodologies Emilia Romagna CLI ORD Cardiovascular and 26 300.000 Respiratory 2321613 Screening for tuberculosis and tuberculosis infection in risk group: new tools for health surveillance Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro ORD Infectious Diseases 26 350.000 and Microbiology 2318122 Creation of the Sicilian Documentation System for safety, quality communication and development of local food products on domestic and international market Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary 26 390.000 Pagina 322 di 332

2316719 Identification of biomarkers to be predictive of PASCALE ORD Immunology 26 400.000 response to anti CTLA4 treatment in the peripheral blood and tissues of melanoma patients. 2312610 Ticks transmitting diseases in Sicily: early detection, diffusion and risk analysis of Tick borne diseases, with particular attention to Anaplasmosis. Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary 26 455.000 2310443 Monitoring of heavy metals and nanoparticles in fishes and babyfoods of animal origin Istituto Zooprofilattico Sperimentale della Sicilia ORD Risk, Prevention 26 457.000 and Health Behavior 2304919 Design, synthesis, biological and theoretical evaluation of new heterocycles as antitumour and antibacterial agents. Sicilia ORD Biological Chemistry and Macromolecular Biophysics 26 525.000 2315382 EXPERIMENTAL AND CLINICAL USE OF STEM CELLS IN THE TREATMENT OF HEART FAILURE Sicilia ORD Cardiovascular and 26 592.000 Respiratory 2320746 Control of Feral Dog Populations by Immunocontraception Istituto Zooprofilattico Sperimentale del Lazio e della Toscana EST Veterinary 26,25 415.000 2304481 2316247 2316837 An improve of tumor regression with a cancer risk modulated radiochemotherapy in local advanced rectal cancer (LARC) can lead to avoid doing major surgery: a randomized phase II study. Study on polymorphisms within micro RNAbinding sites of CD86 in Umbrian population and risk of sporadic colorectal cancer. Regional network for diagnosis and treatment of early arthritis Emilia Romagna CLI ORD Oncology 2 26,25 600.000 Umbria ORD Oncology 1 Basic 26,5 47.500 Piemonte CLI ORD Musculoskeletal, 26,5 150.000 Oral and Skin Pagina 323 di 332

2307862 2322083 2319054 2316301 2321993 2319502 2316102 2318034 2316194 Multicentre prospective study on interventional endoscopic ultrasound complications The automatic visuospatial attentional component in Parkinson's disease: a pilot study Assessment framework of cortical plasticity following stroke Treatment of Kaposi s Sarcoma by Electrochemotherapy: and Virological evaluation Pharmacological target identification for high risk neuroblastoma therapy Effect of long term Physical Activity training on health: epigenetic and OMICs integrated approaches In vitro and in vivo Neuroblastoma models for predicting Voacamine dose response implementation and implications of 3D anatomical libraries in Radiation Oncology Pathogenesis of Multiple Sclerosis: role of Fas/FasLigand and TNFalfa/TNFR1 and TNFR2 systems in the apoptosis of T cells autoreactive to myelin Sicilia CLI ORD Oncology 2 26,5 165.000 S.CAMILLO CLI ORD Integrative, Functional, and Cognitive 26,5 190.000 SANTA LUCIA ORD Brain Disorders and 26,5 195.000 SAN GALLICANO CLI ORD Surgical, Biomedical Imaging, and Bioengineering 26,5 200.000 FATEBENEFRATELLI ORD Oncology 2 26,5 250.000 SDN EST Interdisciplinary 26,5 441.000 Molecular and Training Istituto Superiore di Sanita' ORD Oncology 2 26,5 530.000 Emilia Romagna ORD Oncology 2 26,5 530.000 NEUROLESI ORD Immunology 26,5 550.000 Pagina 324 di 332

2315127 2320496 Analysis of specific markers of mental health, after time by admissions to a hospital, for onset of psychiatric disorders in developmental age. Immunological properties of fetal stem cells retrieved from placenta and amniotic fluid Sicilia CLI ORD Biobehavioral and 26,75 150.000 Behavioral Processes Veneto EST Immunology 26,75 492.000 2316917 Title: Study on target therapies Impact in breast cancer patients on a wide area ofnorthern Emilia (AVEN ) Population included in the Reggio Emilia, Modena, Parma,Piacenza Tumour Registry ARCISPEDALE CLI ORD Oncology 2 27 0 2308030 2320492 2321329 2303818 2316689 Development of autoantibody signatures as powerful diagnostic/prognostic biomarkers of inflammatory disorders of the nervous system A Pilot study for implementation of regional guidelines for integrated management of heart failure in ligurian population between hospital and territory ( P.O.N.T.E ). Development of nanoparticles based contrast agents for enhanced biomedical imaging Induced Pluripotent Stem Cells for neurodegenerative disease Suppressing bladder cancer stem cell function by aldehyde dehydrogenase inhibition with disulfiram: phase II clinical trial with biomarker evaluation of clinical response Toscana ORD Immunology 27 150.000 Liguria CLI ORD Healthcare Delivery 27 150.000 and Methodologies NEUROLESI ORD Bioengineering 27 164.000 and Technologies Abruzzo ORD Emerging Technologies and Training in s 27 200.000 Emilia Romagna CLI ORD Oncology 2 27 215.000 2314135 Correlation between activity and genetic polymorphisms of the NF kb gene and erythroid response to iron chelation therapy in patients with myelodysplastic syndrome CROB ORD Oncology 2 27 300.000 Pagina 325 di 332

2313697 Evaluation of circulating endothelial cells as a biomarker of endothelial damage in patients undergoing allogeneic stem cells transplantation (allobmt): correlation with graft versus host disease (GVHD) onset. Lombardia ORD Vascular and 27 360.000 Hematology 2320831 Evaluation of Brucella spp. strains spread in Sicily Istituto Zooprofilattico Sperimentale della Sicilia ORD Veterinary 27 425.000 2320411 2321699 2321779 2317524 2321995 2299325 LIMIT LOAD AND THE MECHANICAL RESPONSE TO THE PHYSIOTHERAPY TREATMENT OF THE NEURO MUSCULAR DEFICIENCY IDENTIFICATION AND ANALYSIS OF MOLECULAR MECHANISM IN SPORADIC AND FAMILIAL FORMS OF CCM. Addictive Disorders in Parkinson s disease: a multidisciplinary approach to understand and prevent The effect of migration waves on rare diseases incidence at birth in Friuli Venezia Giulia Region and comparison of the frequency of perinatal outcomes in children born from Italian, foreign and interracial couples in three Northern Italian Regions. How to personalize the classic and atypical antipsychotic therapy in elderly patients affected by dementia: a pharmacogenetic study. Mechanisms of T lymphocyte immunomodulation: role of IL 27 in the Th1/Tc1 induction in chronic obstructive pulmonary disease (COPD) MAUGERI CLI ORD Bioengineering 27 443.874 and Technologies NEUROLESI ORD Brain Disorders and 27 593.000 Istituto Superiore di Sanita' ORD Brain Disorders and 27,5 0 Friuli Venezia Giulia CLI ORD Population 27,5 266.200 and Epidemiology Piemonte ORD Brain Disorders and 27,5 300.000 MAUGERI ORD Cardiovascular and 27,5 330.000 Respiratory Pagina 326 di 332

2318033 2316574 2321242 ACCEPTANCE CRITERIA FOR THE EVALUATION OF RADIOTHERAPY PLANNING GLYCOGEN STORAGE DISEASE TYPE I AND ATHEROSCLEROSIS. Thermalism role in the management of arthralgia in women treated with aromatase inhibitors Emilia Romagna ORD Oncology 2 27,5 530.000 Friuli Venezia Giulia CLI ORD Vascular and 28 289.300 Hematology Piemonte CLI ORD Oncology 2 28 350.000 2318919 Value of MR combined Imaging in assessment of early response to neoadjuvant theraphy in Locally Advanced Breast Cancer PASCALE ORD Oncology 2 28 450.000 2314777 2321189 2309275 2321963 2316062 Alpha Synuclein as a possible predictive and prognostic marker for Parkinson's Disease Evaluation of recidive risk after resection in hepatocellular carcinoma using a molecular profiling signatures. A New Cross Platform Multi Signature Classifier Approach To Predict Neuroblastoma Patients Outcome TREATMENT OF EARLY STAGE (I II) OROPHARYNGEAL CANCER WITH TRANSORAL ROBOTIC SURGERY VERSUS ESCLUSIVE RADIOTHERAPY: PROSPECTIVE MULTICENTER RANDOMIZED STUDY. Randomized controlled clinical trial comparing Y90 TARE (Transarterial Radioembolisation with Y90) to sorafenib in the treatment of advanced HCC complicated with portal vein thrombosis Istituto Superiore di Sanita' ORD Brain Disorders and 28 470.000 Emilia Romagna ORD Oncology 2 28,5 280.000 GASLINI CLI ORD Oncology 2 28,5 340.000 I.E.O. CLI ORD Oncology 2 28,5 392.000 Emilia Romagna CLI ORD Digestive, Kidney 28,5 600.000 and Urological Systems Pagina 327 di 332

2320380 2302821 2311389 2319011 2308393 2321677 2317860 2320252 Cognitive, genetic and structural features in affective and schizophrenic spectrum disorders. Adjuvant therapy for resected stage III N1 melanoma patients A MODEL TO EVALUATE EFFECTIVENESS AND APPROPRIATENESS OF DRUGS USING THE ITALIAN RFOM REGISTRY Fibrosis, regeneration and cancer: links, molecular pathways and potential role of microvesicles SAFETY ANALYSIS OF RADIOPHARMACEUTICALS PRODUCTION PROCEDURES BY USING ADVANCED ACCELERATOR APPLICATIONS Develop of new whole body Dosemeter for measuring ionizing Radiation to Operators in medical practice and of STErilizable wrist dosemeter (DROSTE) CD39 and CD73 as potential markers to identify women susceptible to recurrent pregnancy loss Blood brain barrier alteration and oxidative stress in neurodegenerative diseases: benefits of melatonin administration Veneto CLI ORD Brain Disorders and 29 35.000 Istituto Superiore di Sanita' CLI EST Oncology 2 29 75.000 I. O. V. CLI ORD Healthcare Delivery 29 90.000 and Methodologies Istituto Superiore di Sanita' ORD Cell Biology 29 150.000 Sicilia CLI ORD Healthcare Delivery 29 167.650 and Methodologies Toscana CLI ORD Surgical, Biomedical Imaging, and Bioengineering 29 177.000 Marche ORD Genes, Genomes 29 180.000 and Genetics FATEBENEFRATELLI ORD Brain Disorders and 29 240.000 2322069 2320977 The nuclear factor HMGA1: a novel gene for early diagnosis and prognosis of type 2 diabetes mellitus Calabria ORD Genes, Genomes 29 250.000 and Genetics Molecular profiles in Male Breast Cancer (MBC) Sicilia ORD Oncology 2 29 500.000 Pagina 328 di 332

2317955 2318348 2303887 2321018 2299281 2321448 Role of T cell subpopulations in the pathogenesis of Multiple Sclerosis A single cross over study to evaluate the effect of bethametasone on acute attacks in episodic ataxia patients. Realization of a complete model of the cardiocirculatory system, by means of hybrid modelling, for testing implant strategies of prosthetic devices. An endoscopic information system for the achievement and the distribution of clinical images and video associated to the surgical procedures Analysis of the correlation between semen parameters and the levels of retinol, tocopherol and carotenoids in human seminal plasma and blood Transplantation of kidneys with small renal tumours: a new strategy for expanding the kidney donor pool NEUROLESI ORD Immunology 29 580.000 SANTA LUCIA CLI ORD Brain Disorders and 29,5 250.000 Istituto Superiore di Sanita' ORD Bioengineering 29,5 272.000 and Technologies Sicilia ORD Surgical, Biomedical Imaging, and Bioengineering 29,75 500.000 Emilia Romagna ORD Endocrinology, Metabolism, Nutrition and Reproductive 30 0 Emilia Romagna ORD Digestive, Kidney 30 150.000 and Urological Systems 2318221 Genotypes of Toxoplasma gondii their phylogeny, pathogenicity and transmission among wildlife, livestock and humans. Eating ectoparasites is an additional factor of risk for infection? Istituto Zooprofilattico Sperimentale del Lazio e della Toscana ORD Veterinary 30 264.000 2312294 Creation of a disease risk model by the identification of genes underling food related traits and their relationship with health status in two isolated populations from Italy. BURLO GAROFALO ORD Genes, Genomes 30 280.000 and Genetics Pagina 329 di 332

2314689 2320088 2316272 2313025 Prevention and treatment of atherosclerotic vascular disease in people living in the same geographical area. SUICIDE ATTEMPTS: FROM EPIDEMIOLOGY TO CLINICAL DIAGNOSIS A GROUP COGNITIVE/BEHAVIOURAL INTERVENTION FOR METABOLIC SYNDROME RISK REDUCTION, IN PATIENTS TREATED WITH ATYPICAL ANTIPSYCOTICS Development of Citotoxic T Lymphocytes (CTL) active against Neuroblastoma: investigation of an immunotherapy approach, production from laboratory to clinic in compliance with Good Manufacturing Practice (GMP) Veneto CLI ORD Vascular and 30 378.200 Hematology Emilia Romagna CLI ORD Risk, Prevention 30,5 107.000 and Health Behavior Emilia Romagna ORD Biobehavioral and 30,5 298.000 Behavioral Processes Emilia Romagna ORD Oncology 2 30,5 300.000 2316051 CONTROL AND MANAGEMENT OF LOGICAL FOOD RISKS: SETUP AND APPLICATION OF INNOVATING MODELS BASED ON TECHNOLOGICAL METHODS FOR DETECTION OF VIRUS, PARASITES AND BACTERIA Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia ORD Veterinary 30,5 340.000 2316840 Novel shuttling hallmarks for bone pathologies GALEAZZI ORD Musculoskeletal, 31 370.000 Oral and Skin 2313989 2318375 Establishing a New Drugs Development Programme at the Istituto Nazionale Tumori Fondazione G. Pascale Normal pressure hydrocephalus and parkinsonism: integration of surgical and medical treatment. PASCALE CLI ORD Oncology 2 31 500.000 CARLO BESTA CLI ORD Brain Disorders and 31,5 422.750 Pagina 330 di 332

2318459 Hospital malnutrition Sicilia CLI ORD Endocrinology, Metabolism, Nutrition and Reproductive 32 175.000 2314265 2318331 2320498 2310805 2314405 2315979 2312897 Preliminary Study on Bone Tissue Regeneration in Massive Loss of Substance in MusculoSkeletal Oncology Evaluation of a novel tumor markers panel in the diagnosis of occult ovarian and tubal cancers in BRCA1 and BRCA 2 mutated women undergoing bilateral prophylactic salpingo oophorectomy: A prospective observational study ROLE OF micrornas IN THE PATHOGENESIS OF BARRETT S ESOPHAGOUS Screening of the genetic alterations in patients affected by high myopia Title: Preclinical evaluation of targeting recipient antigen presenting cells before allogeneic HSCT for the prevention of acute GVHD Investigations on the multifaceted role of Enhancer of Zeste 2 (EZH2) in glioblastoma biology Role of the master transcription factor Yin Yang 1 (YY1) in the diagnosis of bone lesions REGINA ELENA ORD Musculoskeletal, 32 500.000 Oral and Skin I.E.O. CLI ORD Oncology 2 32,5 277.000 Sicilia ORD Oncology 2 33 400.000 Veneto ORD Genes, Genomes 33,5 250.000 and Genetics Emilia Romagna ORD Immunology 36 250.000 CARLO BESTA EST Oncology 1 Basic 36 399.000 SDN CLI ORD Oncology 2 36 450.000 (3) Pagina 331 di 332

LEGENDA : NOTA 1 = Il PI del Progetto ha richiesto un finanziamento inferiore a quello minimo previsto dal Bando NOTA 2 = Principal Investigator non è operatore SSN NOTA 3 = Il Progettoè risultato uguale ad altro progetto presentato nello stesso Bando anche se in altra sezione NOTA 4 = Progetto Giovane Ricercatore Estero Finanziato in quanto con punteggio uguale od inferiore a 8,5 score Limite Finanziamento GR NOTA 5 = Progetto Finanziato per riserva Veterinaria/Sicurezza Alimentare Pagina 332 di 332