Table of Contents. Ralph E. Holmes, M.D.

Table of Contents Ralph E. Holmes, M.D. Personal Data...2 Education...2 Present Position...3 Board Certification...4 Medical Licensure...4 Academic Appointments...4 Hospital Appointments...5 Service to Hospital Committees...7 Membership in Professional Societies...7 Honors and Awards...8 Consulting Positions...8 Editorial Boards...8 Teaching Activities...9 Invited Surgeon...10 Preceptorships...11 Business Activities...11 Presentations at Grand Rounds and Teaching Conferences...12 Presentations at Courses, Panels, Symposia and Workshops...21 Presentations at Scientific and Society Meetings...32 Abstracts and Proceedings...48 Journal Publications...57 Book Chapters...63 Commentary, Communications, Editorials, and Reviews...64 Instructional Videos...65 Media Contributions...66 Curriculum Vitae for Ralph E. Holmes, M.D. - 1

Curriculum Vitae Ralph Edward Holmes, M.D. PERSONAL DATA Birthdate December 8, 1943 San Diego, California Address FACESplus 8010 Frost Street, Suite 412 San Diego, California 92123 Tel: (858) 292-1075 Fax: (858) 292-8283 Center for Craniofacial Disorders Children s Hospital and Health Center 3020 Children s Way San Diego, California 92123 Tel: (619) 576-4073 Fax: (619) 974-8059 Email: rholmes@sdfaces.com rholmes@ucsd.edu EDUCATION Boston University Six year CLA-MED Program 121 Bay State Road Boston, Massachusetts 02215 80 East Concord Street Boston, Massachusetts 02118 1961-67 B.A., M.D. Santa Clara Valley Medical Center 751 South Bascom Avenue San Jose, California 95128 1967-68 Rotating Intern Program Director: R. Morton Manson, M.D. Curriculum Vitae for Ralph E. Holmes, M.D. - 2

Boston University Medical Center 75 East Newton Street Boston, Massachusetts 02118 1968-69 General Surgery Resident Program Director: Richard H. Egdahl, M.D. Yale-New Haven Medical Center 333 Cedar Street New Haven, Connecticut 06510 1969-72 Otolaryngology Resident Program Director: John A. Kirchner, M.D. University of Texas Health Science Center 5323 Harry Hines Boulevard Dallas, Texas 75235 1974-76 Plastic Surgery Research Fellow Program Director: Kenneth E. Salyer, M.D. University of Texas Health Science Center 5323 Harry Hines Boulevard Dallas, Texas 75235 1976-78 Plastic Surgery Resident Program Director: Kenneth E. Salyer, M.D. PRESENT POSITION Plastic Surgeon FACESplus 8010 Frost Street, Suite 412 San Diego, California 92123 Associate Chief Craniofacial Surgical Services Center for Craniofacial Disorders Children s Hospital and Health Center 3020 Children s Way San Diego, California 92123 Clinical Professor of Surgery Division of Plastic Surgery, Voluntary Faculty University of California at San Diego School of Medicine 350 Dickinson Street, Room 412 San Diego, California 92103-8890 Curriculum Vitae for Ralph E. Holmes, M.D. - 3

BOARD CERTIFICATION 1968 - National Board of Medical Examiners Certificate No. 91820, Issued July 1, 1968 1972 - American Board of Otolaryngology Certificate No. (none), Issued October 27, 1972 1981 - American Board of Plastic Surgery Certificate No. 2493, Issued November 20, 1981 MEDICAL LICENSURE 1969 - Physician and Surgeon, State of Connecticut Certificate No. 14406, Issued May 25, 1970 1972 - Physician and Surgeon, State of California Certificate No. G-24863, Issued: July 3, 1973 1974 - Physician and Surgeon, State of Texas Certificate No. E3307, Issued: December 4, 1974 ACADEMIC APPOINTMENTS 1972-73 Assistant Professor of Surgery Section of Otolaryngology Yale University 333 Cedar Street New Haven, Connecticut 06510 1973-74 Assistant Professor of Surgery Division of Otolaryngology University of California 225 Dickinson Street San Diego, California 92103 1977-78 Instructor of Surgery Division of Plastic Surgery University of Texas Health Science Center 5323 Harry Hines Boulevard Dallas, Texas 75235 1978-82 Assistant Professor of Surgery Division of Plastic Surgery University of Texas Health Science Center 5323 Harry Hines Boulevard Dallas, Texas 75235 Curriculum Vitae for Ralph E. Holmes, M.D. - 4

1982-84 Adjunct Professor of Research Division of Orthopedic Surgery University of Texas Health Science Center 5323 Harry Hines Boulevard Dallas, Texas 75235 1985-95 Associate Professor of Surgery Division of Plastic Surgery University of California 200 West Arbor Drive San Diego, California 92103-8890 1995-99 Professor of Surgery & Head Division of Plastic Surgery University of California 200 West Arbor Drive San Diego, California 92103-8890 1999- Clinical Professor of Surgery Division of Plastic Surgery University of California 200 West Arbor Drive San Diego, California 92103-8890 HOSPITAL APPOINTMENTS 1972-73 Yale-New Haven Medical Center 333 Cedar Street New Haven, Connecticut 06510 Attending, Otolaryngology 1972-73 VA Medical Center West Spring Street West Haven, Connecticut 06516 Consultant, Otolaryngology 1973-74 UCSD Medical Center 200 West Arbor Drive San Diego, California 92103 Attending, Otolaryngology 1973-74 VA Medical Center 3350 La Jolla Village Drive La Jolla, California 92161 Attending, Otolaryngology Curriculum Vitae for Ralph E. Holmes, M.D. - 5

1973-74 Scripps Clinic and Research Foundation 476 Prospect Street La Jolla, California 92037 Visiting Associate, Otolaryngology 1973-74 Mercy Hospital 4077 5th Avenue San Diego, California 92103 Courtesy Staff, Otolaryngology 1978-82 VA Medical Center 4500 South Lancaster Road Dallas, Texas 75216 Chief, Plastic Surgery Section 1978-82 Parkland Memorial Hospital 5201 Harry Hines Boulevard Dallas, Texas 75235 Attending, Plastic Surgery 1978-82 Children s Medical Center 1935 Motor Street Dallas, Texas 75235 Attending, Plastic Surgery 1982-84 Presbyterian Medical Center 8200 Walnut Hill Lane Dallas, Texas 75231 Attending, Plastic Surgery 1985- UCSD Medical Center 200 West Arbor Drive San Diego, California 92103-8890 Attending, Plastic Surgery 1985- VA Medical Center 3350 La Jolla Village Drive La Jolla, California 92161 Attending, Plastic Surgery 1985- Children's Hospital and Health Center 3020 Children s Way San Diego, California 92123 Attending, Plastic Surgery Curriculum Vitae for Ralph E. Holmes, M.D. - 6

1991-2000 Mercy Hospital and Medical Center 4077 5th Avenue San Diego, California 92103 Attending, Plastic Surgery 1992- Sharp Memorial Hospital 7901 Frost Street San Diego, California 92123 Attending, Plastic Surgery 1992-95 Grossmont Hospital 5555 Grossmont Center Drive La Mesa, California 91944 Attending, Plastic Surgery SERVICE TO HOSPITAL COMMITTEES Animal Facility Subcommittee Veterans Administration Medical Center Dallas, Texas 1978-82 Cancer Committee Veterans Administration Medical Center Dallas, Texas 1979-82 Research and Development Committee Veterans Administration Medical Center Dallas, Texas 1980-82 MEMBERSHIP IN PROFESSIONAL SOCIETIES 1972- American Academy of Otolaryngology 1974- American Medical Association 1974-84 Texas Medical Association 1974-84 Dallas County Medical Society 1978-84 Dallas Society of Plastic and Reconstructive Surgeons 1979- Plastic Surgery Research Council 1980- Society for Biomaterials 1982- American Society of Plastic and Reconstructive Surgeons 1984- Orthopaedic Research Society 1986- American Association for Dental Research 1986- California Medical Society 1986- San Diego County Medical Society 1989- American Association of Plastic Surgeons Curriculum Vitae for Ralph E. Holmes, M.D. - 7

1992- California Society of Plastic Surgeons 1992-99 Association of Academic Chairmen in Plastic Surgery HONORS AND AWARDS 1977 - The Hektoen Gold Medal for Original Investigation, awarded to "Spectrum of Research and Clinical management of Craniofacial Anomalies", by Kenneth E. Salyer, M.D., Donnell F. Johns, Ph.D., Ronald W. Atkins, M.D. and Ralph E. Holmes, M.D. Exhibited at the 126th Annual Convention of the American Medical Association, San Francisco, California. 1978 - Grand Prize for Scientific Presentations, Plastic Surgery Senior Residents' Conference, Hershey, Pennsylvania. 1992 - ASMS Best Paper Award, 61th Annual Meeting of the American Society of Maxillofacial Surgeons, Washington D.C., September 22, 1992. CONSULTING POSITIONS 1. Consultant on Osteoplastic Instrumentation, Midas Rex Pneumatic Tools, Fort Worth, Texas, 1976-1984. 2. Consultant on Osteogenic Cell Culture Techniques. Maxillofacial Research Service, VA Medical Center, Wilmington, Delaware, March 13-14, 1980. 3. Consultant on Skin Suture Instrumentation, Midas Rex Pneumatic Tools, Fort Worth, Texas, 1981-1984. 4. Consultant on Implant Bone Regeneration, Interpore International, Irvine, California, 1984 - Present. 5. Consultant on Implant Bone Regeneration, American Edwards Laboratories, Irvine, California, 1986-1992. 6. Consultant on Osteogenic Factor, Ingene Corporation, Santa Monica, California, 1987-1992. 7. Consultant to the Naval Hospital, Dental Department, San Diego, California, 1987-1992. 8. Consultant to the International Craniofacial Institute, Humana Advanced Surgery Institute, Dallas, Texas, 1989-1992. 9. Consultant on Protected Bone Regeneration, Macropore, Inc., San Diego, California, 1996 - present. 10. Consultant on Artecoll Skin Fillers, Artes Medical, Inc., San Diego, California, 1998 - present. 11. Consultant on Medical Practice Management Software, LeonardoMD, Inc., San Diego, California, 2000 present. EDITORIAL BOARDS Editorial Board Annals of Plastic Surgery 1988-1991 Curriculum Vitae for Ralph E. Holmes, M.D. - 8

Editorial Board Plastic and Reconstructive Surgery 1991-1997 Reviewer Journal of Orthopaedic Research 1988-Present Journal of Craniofacial Surgery 1994-Present TEACHING ACTIVITIES Program Committee Eighteenth Annual Senior Residents' Conference Dallas, Texas April 12-14, 1979 Co-Chairman Workshop on Soft Tissue Response to Mechanical Stress Veterans Administration Medical Center Dallas, Texas November 5-7, 1980 Cleft Lip and Palate Surgery Team Proyecto Huasteco Veracruz, Mexico 1980-84 Co-Chairman Interdisciplinary Course on Bone Grafting: Biology and Applications San Diego, California December 4-6, 1981. UCSD Interface Surgery Program San Diego, California 1986-Present Faculty Member Association for the Study of Internal Fixation Davos, Switzerland 1987-Present Co-Chairman Third San Diego Bone Grafting Symposium Curriculum Vitae for Ralph E. Holmes, M.D. - 9

San Diego, California December 1-4, 1988 Chairman AO/ASIF Maxillofacial Rigid Fixation Workshop Santa Ana, California May 19-20, 1989 Chairman AO/ASIF Maxillofacial Rigid Fixation Workshop San Diego, California March 31, 1990 Chairman AO/ASIF Maxillofacial Basic Course San Diego, California June 5-8, 1991 Chairman Medicine Meets Virtual Reality I San Diego, CA June 4-7, 1992 INVITED SURGEON Fronto-Orbital Distraction with Jeffrey Fearon, M.D. Medical City Dallas, Dallas, Texas, February 2, 2000. Monobloc Distraction with Ernesto Ruas, M.D. All Children s Hospital, Tampa, Florida, April 28, 2000. LeFort III Distraction with Jeffrey Marsh, M.D. St. Louis Children s Hospital, St. Louis, Missouri, June 8, 2000, Monobloc Distraction with Chris Gordon, M.D. Children s Hospital of Pittsburgh, Pennsylvania, June 28, 2000. LeFort III Distraction with William Hoffman, M.D. UCSF Medical Center, San Francisco, California, July 17, 2000. Monobloc and Facial Bipartition Distraction with Brett LeHocky, M.D., D.D.S., Loma Linda University Medical Center, Loma Linda, California, August 3, 2000. LeFort III Distraction with Joseph McCarthy, M.D., NYU Medical Center, New York City, New York, November 1, 2000. Curriculum Vitae for Ralph E. Holmes, M.D. - 10

LeFort III Distraction with Chris Gordon, M.D. Children s Hospital of Pittsburgh, Pennsylvania, November 7, 2000. LeFort III Distraction with Arun Gosain, M.D., Children s Hospital of Wisconsin, Milwaukee, Wisconsis, December 4, 2000. LeFort III Distraction with Jayesh Panchal, M.D., Children s Hospital of Oklahoma City, Oklahoma City, Oklahoma, December 5, 2000. PRECEPTORSHIPS Ha M. Le: Computerized Quantitative Analysis of Porous Substrates. UCSD ISP June1992 Christopher King Histology Paper Tasha Tuon-Van Le: Cleft Lip and Palate: Growth Curves Compared to Controls. UCSD ISP June 2000. Committee Chair. Shahrad Rady Rahban: Comparison of Bone Ingrowth and Resorption of Hydroxyapatite/Aragonite Granules and Calcium sulfate Pellets in a Rabbit Tibia Model. UCSD ISP, June 2000. Committee Chair. BUSINESS ACTIVITIES 1996 Present Founder, Clinical Director MacroPore, Inc. San Diego, California 2000 Present Founder, Medical Director LeonardoMD, Inc. San Diego, California Curriculum Vitae for Ralph E. Holmes, M.D. - 11

PRESENTATIONS AT GRAND ROUNDS AND TEACHING CONFERENCES 1. Holmes, R.E.: Bone Regeneration in Coral Microstructure Implants. Conference, Department of Biology, University of California, Los Angeles, California, November 7, 1977. 2. Holmes, R.E.: Bone Regeneration in Coral Microstructure Implants. Conference, Department of Surgery, Harbor General Hospital, Torrance, California, November 8, 1977. 3. Holmes, R.E.: Coral Microstructure in Bone Regeneration. Conference, Discovery Bay Marine Laboratory, University of the West Indies, Jamaica, December 15, 1977. 4. Holmes, R.E.: Bone Regeneration in Coralline Hydroxyapatite. Conference, Johnson and Johnson Research Foundation, New Brunswick, New Jersey, May 19, 1978. 5. Holmes, R.E.: Microvascular Implant Architecture. Conference, W. L. Gore & Associates, Flagstaff, Arizona, October 24, 1978. 6. Holmes, R.E.: The Physiology of Bone Grafting. Conference, Division of Plastic and Reconstructive Surgery, University of California at San Diego, California, March 22, 1979. 7. Holmes, R.E.: Ear Reconstruction. Selected Readings in Plastic Surgery, Plastic Surgery Service, Baylor Medical Center, Dallas, Texas, May 12, 1979. 8. Holmes, R.E.: The Physiology of Bone Grafting. Conference, Division of Orthopaedic Surgery, University of Texas Health Science Center, Dallas, Texas, May 17, 1979. 9. Holmes, R.E.: Implantation: Bone, Cartilage and Alloplastic Materials. Selected Readings in Plastic Surgery, Plastic Surgery Service, Baylor Medical Center, Dallas, Texas, June 7, 1980. 10. Holmes, R.E.: The Periodontium and Alveolar Bone. Oral Embryology and Oral Histology Course, Department of Microscopic Anatomy, Baylor College of Dentistry, Dallas, Texas, May 7, 1981. 11. Holmes, R.E.: Clinical Applications of Newer Biological Materials in Bone Augmentation of the Jaws. Mandibular Ramus Frame Implant Course, The Baylor College of Dentistry, Dallas, Texas, December 7-9, 1981. Curriculum Vitae for Ralph E. Holmes, M.D. - 12

12. Holmes, R.E.: Research in Bone Regeneration. Conference, Division of Plastic Surgery, Academic Hospital, Uppsala, Sweden, January 18, 1982. 13. Holmes, R.E.: The Biology of Bone Grafting. Conference, Division of Orthopaedic Surgery, University of Texas Health Science Center, Dallas, Texas, April 22, 1982. 14. Holmes, R.E.: Bone Research Techniques: Alveoloplasty and Mandibuloplasty. Oral Embryology and Oral Histology Course, Department of Microscopic Anatomy, Department of Anatomy, Baylor College of Dentistry, Dallas, Texas, April 29, 1982. 15. Holmes, R.E.: Bone Regeneration. Conference, Division of Orthopaedic Surgery, University of Texas Health Science Center, Dallas, Texas, September 8, 1983. 16. Holmes, R.E.: The Biology of Bone Grafts and Implants. Conference, Division of Orthopaedic Surgery, UCD School of Medicine, Davis, California, September 3, 1984. 17. Holmes, R.E.: The Biology of Bone Grafts and Implants. Conference, Division of Orthopaedic Surgery, UCSD School of Medicine, San Diego, California, September 5, 1984. 18. Holmes, R.E.: The Biology of Bone Grafts and Implants. Conference, Division of Orthopaedic Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, September 18, 1984. 19. Holmes, R.E.: The Biology of Bone Grafts and Implants. Conference, Division of Orthopaedic Surgery, University of Florida School of Medicine, Gainesville, Florida, September 20, 1984. 20. Holmes, R.E.: Bone Regeneration. Conference, Division of Oral Surgery, University of Texas Health Science Center, Dallas, Texas, October 10, 1984. 21. Holmes, R.E.: Regeneration of Bone in Grafts and Implants. Conference, Department of Oral Surgery, The Baylor College of Dentistry, Dallas, Texas, January 16, 1985. 22. Holmes, R.E.: Porous Hydroxyapatite as a Bone Graft Substitute. Conference, Division of Plastic and Reconstructive Surgery, University of California, Los Angeles, California, May 16, 1985. 23. Holmes, R.E.: Porous Hydroxyapatite Update. Conference, Department of Oral Surgery, The Baylor College of Dentistry, Dallas, Texas, September 23, 1985. Curriculum Vitae for Ralph E. Holmes, M.D. - 13

24. Holmes, R.E.: The Biology of Bone Grafts and Implants. Conference, Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, Minnesota, June 3, 1986. 25. Holmes, R.E.: The Biology of Bone Grafts and Implants. Conference, Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, June 5, 1986. 26. Holmes, R.E.: Histometry in Bone Graft and Implant Studies. Conference, Department of Oral and Maxillofacial Surgery, Louisiana State University Medical Center School of Dentistry, New Orleans, Louisiana, June 17, 1986. 27. Holmes, R.E.: Porous Hydroxyapatite Bone Graft Substitutes. Conference, Division of Plastic Surgery, University of Alabama, Birmingham, Alabama, July 14, 1986. 28. Holmes, R.E.: Histologic and Histometric Techniques in Implant and Bone Graft Studies. Conference, Division of Orthopaedics & Rehabilitation, University of California, San Diego, California, December 8, 1986. 29. Holmes, R.E.: Histometry in Bone Graft and Implant Studies. Conference, Division of Plastic and Reconstructive Surgery, St. Francis Hospital, San Francisco, California, December 13, 1986. 30. Holmes, R.E.: Bone Grafts and Implants in Maxillofacial Surgery. Conference, Division of Oral Surgery, Naval Hospital, San Diego, California, June 22, 1987. 31. Holmes, R.E.: Bone Graft Substitutes - What's New In Irvine. Conference, Division of Plastic Surgery, University of California, Irvine, California, April 3, 1989. 32. Holmes, R.E.: Principles of Histometry - How to Avoid the Marshmallow Syndrome. Division of Head and Neck, H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, Florida, June 16, 1989. 33. Holmes, R.E.: Bone Graft Substitutes in Reconstructive Surgery - How to Fool Mother Nature. Division of Head and Neck, H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, Florida, June 17, 1989. 34. Rosenstein, D.A., Holmes, R.E.: Applications of Histometry in Orthopaedic Research. Conference, Division of Orthopaedics & Rehabilitation, University of California, San Diego, California, July 2, 1990. Curriculum Vitae for Ralph E. Holmes, M.D. - 14

35. Holmes, R.E.: Material and Architectural Properties of HA/Collagen Bone Graft Substitutes. Conference, Norian, Mountain, California, November 14, 1991. 36. Holmes, R.E.: Bone Studies on Osseointegrated Implants. Conference, San Diego County Oral and Maxillofacial Surgeons, Scripps Memorial Hospital, San Diego, California, May 26,1992. 37. Holmes, R.E.: Dental Implant Research at UCSD. Conference, San Diego Implant Study Group, Mission Valley Marriott, San Diego, California, September 30,1992. 38. Holmes, R.E., Berger, J.S.: Craniofacial Abnormalities in Children. Grand Rounds, Children s Hospital and Health Center, San Diego, California, January 15, 1993. 39. Holmes, R.E., Le, H.M.: Craniofacial Reconstruction. Sandia Process Development Laboratory, Albuquerque, New Mexico, June 14, 1993 40. Holmes, R.E., Berger, J.S.: Current Concepts in Management of Craniofacial Deformities. Grand Rounds, Children s Hospital and Health Center, San Diego, California, March 3, 1995. 41. Holmes, R.E.: Craniofacial Deformities. Grand Rounds, San Diego County Medical Society, San Diego, California, July 8, 1995. 42. Holmes, R.E.: Current Concepts in Craniofacial Surgery, UCSD Surgical Grand Rounds, VA Medical Center, San Diego, California, December 2, 1995. 43. Holmes, R.E.: Bone Substitute Research: A Review. Department of Orthopaedic Surgery, Gotenburg, Sweden, January 16-17, 1997. 44. Holmes, R.E.: Biology of Porous HA Bone Graft Substitutes. San Diego Neurosurgical Society, San Diego, California, February 25, 1998. 45. Holmes, R.E.: Basic Science and Clinical Applications of HA Cement in Cranioplasty. San Diego Neurosurgical Society, San Diego, California, September 30, 1998. 46. Holmes, R.E.: Cleft Lip, Palate and Craniofacial Reconstruction. AboutFace Craniofacial Support Group, San Diego, California, October 29, 1998. 47. Holmes, R.E.: MacroPore Resorbable Fixation: Ready for National Launch? Conference, Division of Plastic Surgery, University of California, San Diego, California, April 7, 1999. Curriculum Vitae for Ralph E. Holmes, M.D. - 15

48. Holmes, R.E.: Clinical Review of Resorbable Fixation. Conference, Division of Plastic Surgery, Children s Hospital of Pennsylvania, Philadelphia, Pennsylvania, May 10, 1999. 49. Holmes, R.E.: Clinical Review of Resorbable Fixation. Conference, Oral Surgery Department, Wilmington, Delaware, May 12, 1999. 50. Holmes, R.E.: Clinical Review of Resorbable Fixation. Conference, Craniofacial Clinic, Boston Children s Hospital, Boston, Massachusetts, June 7, 1999. 51. Holmes, R.E.: Clinical Review of Resorbable Fixation. Conference, Division of Oral & Maxillofacial Surgery, Hartford Hospital, Hartford, Connecticut, June 9, 1999. 52. Holmes, R.E.: Clinical Review of Resorbable Fixation. Conference, International Center for Craniofacial Surgery, Dallas, Texas, June 15, 1999. 53. Holmes, R.E.: Clinical Review of Resorbable Fixation. Conference, Department of Head & Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, June 22, 1999. 54. Holmes, R.E.: Clinical Review of Resorbable Fixation. Conference, Division of Head & Neck Surgery, Yale University Medical Center, New Haven, Connecticut, July 8, 1999. 55. Holmes, R.E.: Clinical Review of Resorbable Fixation. Conference, Division of Plastic & Reconstructive Surgery, Yale University Medical Center, New Haven, Connecticut, July 8, 1999. 56. Holmes, R.E.: Clinical Review of Resorbable Fixation. Conference, Division of Plastic & Reconstructive Surgery, University of Alabama Medical Center, Birmingham, Alabama, July 22, 1999. 57. Holmes, R.E.: Clinical Review of Resorbable Fixation. Conference, Division of Plastic Surgery, University of Florida Medical Center, Miami, Florida, October 5, 1999. 58. Holmes, R.E.: Protected Bone Regeneration What is it and How can we help it? Conference, Division of Oral & Maxillofacial Surgery, University of Florida Medical Center, Miami, Florida, October 5, 1999. 59. Holmes, R.E.: Clinical Review of Resorbable Fixation. Conference, Combined Division of Plastic & Reconstructive Surgery, Division of Otolaryngology-HNS, and Department of Oral & Maxillofacial Surgery, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, December 14, 1999. Curriculum Vitae for Ralph E. Holmes, M.D. - 16

60. Holmes, R.E.: Clinical Review of Resorbable Fixation. Conference, Department of Oral & Maxillofacial Surgery, Saint Josephs Medical Center, Patterson, New Jersey, December 15, 1999. 61. Holmes, R.E., Cohen, S.R.: Clinical Review of Resorbable Fixation. Conference, Division of Plastic Surgery, Loma Linda University Medical School, Loma Linda, California, January 6, 2000. 62. Holmes, R.E., Cohen, S.R.: Protected Bone Regeneration. Conference, Division of Plastic Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, New York, New York, February 8, 2000. 63. Holmes, R.E., Cohen, S.R.: Protected Bone Regeneration. Conference, Division of H&N-Otolaryngology, State University of New York School of Medicine, Stony Brook, New York, February 9, 2000. 64. Holmes, R.E., Cohen, S.R.: Craniofacial Malformation A Surgical Perspective. Division of Otolaryngology-Head and Neck Surgery, University of California, San Diego, California, March 3, 2000. 65. Holmes, R.E., Cohen, S.R.: Clinical Review of Resorbable Fixation. Conference, Division of Plastic Surgery, University of South Florida Medical Center, Tampa, Florida, April 27, 2000. 66. Cohen, S.R., Holmes, R.E.: Craniofacial Distraction using the MID System and Resorbable Fixation. Conference, Division of Plastic Surgery, University of South Florida Medical Center, Tampa, Florida, April 27, 2000. 67. Holmes, R.E., Cohen, S.R.: Clinical Review of Resorbable Fixation. Conference, Division of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, June 28, 2000. 68. Cohen, S.R, Holmes, R.E.: Craniofacial Distraction using the MID System and Resorbable Fixation. Conference, Division of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, June 28, 2000. 69. Holmes, R.E., Cohen, S.R.: New Techniques in Craniomaxillofacial Surgery Using Resorbable Devices. Department of Otolaryngology-Head and Neck Surgery Conference, University of California at Irvine, Irvine, California, July 15, 2000. 70. Holmes, R.E., Cohen, S.R.: Biologic Concepts of Resorbable Fixation and Protected Bone Regeneration. Division of Plastic Surgery Conference, University of California at San Francisco, San Francisco, California, September 05, 2000. Curriculum Vitae for Ralph E. Holmes, M.D. - 17

71. Holmes, R.E., Cohen, S.R.: Review of Resorbable Device Biology and Applications in Craniomaxillofacial Surgery. Division of Plastic Surgery Conference, University of California at Davis, Sacramento, California, September 12, 2000. 72. Holmes, R.E., Cohen, S.R.: Resorbable Devices in Craniofacial Surgery: Biologic Concepts, Protected Bone Regeneration and In-Situ Contouring. Conference, Institute of Plastic and Reconstructive Surgery, New York University Medical Center, New York, New York, November 1, 2000. 73. Cohen, S.R, Holmes, R.E.: Pediatric Craniofacial Reconstruction with Bioresorbable Tacks and Distraction. Institute of Plastic and Reconstructive Surgery, New York University Medical Center, New York, New York, November 1, 2000. 74. Holmes, R.E., Cohen, S.R.: Resorbable Devices for CMF Surgery: Basic Science and Clinical Review, Multispecialty Grand Rounds, Jefferson University, Philadelphia, Pennsylvania, November 6, 2000. 75. Holmes, R.E., Cohen, S.R.: Resorbable Devices for CMF Surgery: Basic Science and Clinical Review, Skull Base Conference, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, November 7, 2000. 76. Holmes, R.E., Cohen, S.R.: Resorbable Devices in Craniomaxillofacial, Neurological and Spine Surgery. Conference, Divisions of Plastic and Reconstructive Surgery and Neurosurgery, Oregon Health Science University, Portland, Oregon, November 10, 2000. 77. Holmes, R.E., Cohen, S.R.: New Techniques in Craniofacial Surgery using Resorbable Fixation and Protected Bone Regeneration. Division of H&N Surgery Conference, Stanford University Medical Center, Palo Alto, California, November 16, 2000. 78. Holmes, R.E., Cohen, S.R.: Biologic Concepts of Resorbable Fixation and Protected Bone Regeneration. Division of Plastic Surgery Conference, Medical College of Wisconsin, Milwaukee, Wisconsin, December 4, 2000. 79. Cohen, S.R., Holmes, R.E.: Pediatric Craniofacial Surgery using Resorbable Devices. Division of Plastic Surgery Conference, Medical College of Wisconsin, Milwaukee, Wisconsin, December 4, 2000. Curriculum Vitae for Ralph E. Holmes, M.D. - 18

80. Holmes, R.E., Cohen, S.R.: Review of Resorbable Implant Biology and Applications in Craniomaxillofacial Surgery. Division of H&N Surgery Conference, University of California at Davis, Sacramento, California, December 14, 2000. 81. Holmes, R.E., Cohen, S.R.: Resorbable Implants for Fixation, Bone Reconstruction, and Bone Regeneration. University Medical Center, Fresno, California, February 21, 2001. 82. Cohen, S.R., Holmes, R.E.: Pediatric Craniofacial Surgery using Resorbable Devices. University Medical Center, Fresno, California, February 21, 2001. 83. Holmes, R.E., Cohen, S.R.: Review of Resorbable Implant Biology and Applications in Craniomaxillofacial Surgery. Division of H&N Surgery Conference, Kaiser Permanente Medical Center, Portland, Oregon, February 28, 2001. 84. Holmes, R.E., Cohen, S.R.: Resorbable Implants for Skeletal Fixation: Basic Science and Clinical Review. University of Nevada, Reno, Nevada, April 6, 2001. 85. Cohen, S.R., Holmes, R.E.: Pediatric Craniofacial Surgery using Resorbable Devices. University of Nevada, Reno, Nevada, April 6, 2001. 86. Holmes, R.E., Cohen, S.R.: Resorbable Implants for Bone Fixation and Reconstruction: Basic Science and Clinical Review. Division of Plastic and Reconstructive Surgery, University of California, Los Angeles, California, July 12, 2001. 87. Cohen, S.R., Holmes, R.E.: Pediatric Craniofacial Surgery using Resorbable Devices. Division of Plastic and Reconstructive Surgery, University of California, Los Angeles, California, July 12, 2001. 88. Holmes, R.E.: Resorbable Devices in Spine Surgery: Coming to Your Neighborhood OR? Texas Back Institute, Dallas, Texas, August 10, 2001. 89. Holmes, R.E., Cohen, S.R.: Resorbable Polymers: Their Properties and Biologic Behavior. Australian Craniofacial Institute, Adelaide, South Australia, Australia, August 27, 2001. 90. Holmes, R.E., Cohen, S.R.: Clinical Review of Resorbable Fixation in CMF, Neurosurgical and Orthopedic Applications. Australian Craniofacial Institute, Adelaide, South Australia, Australia, August 27, 2001. Curriculum Vitae for Ralph E. Holmes, M.D. - 19

91. Cohen, S.R., Holmes, R.E.: Pediatric Craniofacial Surgery using Mesh and Tacks and Endoscopic Treatment of Craniosynostosis with Immediate Reconstruction. Australian Craniofacial Institute, Adelaide, South Australia, Australia, August 27, 2001. 92. Cohen, S.R., Holmes, R.E.: Neonatal Mandibular Distraction and Craniofacial Distraction. Australian Craniofacial Institute, Adelaide, South Australia, Australia, August 27, 2001. 93. Holmes, R.E.: Starting a Biotechnology Company What Does It Take? Bone Tissue Engineering Center, Carnegie Mellon University, Pittsburgh, Pennsylvania, March 22, 2002. 94. Holmes, R.E.: Ear Reconstruction, Surgical Inservice, Children s Hospital, San Diego, California, March 21, 2003. Curriculum Vitae for Ralph E. Holmes, M.D. - 20

PRESENTATIONS AT COURSES, PANELS, SYMPOSIA AND WORKSHOPS 1. Holmes, R.E.: Avulsion Injuries of the Face and Scalp. Workshop in Soft Tissue Surgery, Department of Otolaryngology, University of Texas Health Science Center, Southwestern Medical School, Dallas, Texas, September 14-16, 1978. 2. Holmes, R.E.: Bone Regeneration in Porous Hydroxyapatite Implants. Johnson & Johnson Symposium on Animal and Human Studies of Replamineform Hydroxyapatite as a Bone Implant. Hyatt Regency, Dallas, Texas, January 31, 1981. 3. Holmes, R.E.: Management of Carcinoma of the Skin, Including Malignant Melanoma. The 67th Clinical Congress of the College of Surgeons, San Francisco, California, October 11-16, 1981. 4. Holmes, R.E.: Fate of the Autogeneous Bone Graft. Interdisciplinary Course on Bone Grafting: Biology and Applications. The Plastic Surgery Research Foundation of San Diego, California, December 4-6, 1981. 5. Holmes, R.E.: Development and Application of a Coralline Hydroxyapatite Matrix for Bone Regeneration. Interdisciplinary Course on Bone Grafting: Biology and Applications. The Plastic Surgery Research Foundation of San Diego, California, December 4-6, 1981. 6. Holmes, R.E.: Alternative Methods for Successful Mandible Grafting. Panel, Interdisciplinary Course on Bone Grafting: Biology and Applications. The Plastic Surgery Research Foundation of San Diego, California, December 4-6, 1981. 7. Holmes, R.E.: Maxillary and Mandibular Atrophy, Alveolar Clefts, and Other Dental Applications. Interdisciplinary Course on Bone Grafting: Biology and Applications. The Plastic Surgery Research Foundation of San Diego, California, December 4-6, 1981. 8. Holmes, R.E.: Physiology of Bone. The 27th Annual Meeting of the Plastic Surgery Research Council, San Diego, California, March 14-17, 1982. 9. Holmes, R.E.: The Physiology of Heterotopic Bone Formation. The 15th Annual meeting of the American Burn Association, New Orleans, Louisiana, March 16-19, 1983. 10. Holmes, R.E.: Research Update. The 63rd Annual meeting of the American Association of Plastic Surgeons, Chicago, Illinois, May 6-9, 1984. Curriculum Vitae for Ralph E. Holmes, M.D. - 21

11. Holmes, R.E.: Periodontal Applications of Interpore 200. Workshop, Department of Periodontics, UCLA School of Medicine and Dentistry, Los Angeles, California, June 14-15, 1984. 12. Holmes, R.E.: Periodontal Applications of Interpore 200. Workshop, Department of Periodontics, UCLA School of Medicine and Dentistry, Los Angeles, California, July 19-20, 1984. 13. Holmes, R.E.: Bone Graft Substitutes. AO/ASIF Maxillofacial Course, The Association for the Study of Internal Fixation, San Diego, California, June 28 - July 2, 1987. 14. Holmes, R.E.: Scientific Principles of Bone Plating. Facial Plating Symposium, Naval Hospital, San Diego, California, February 27, 1988. 15. Holmes, R.E.: Fracture Healing - Stable and Unstable Conditions. AO/ASIF Maxillofacial Course, The Association for the Study of Internal Fixation, Kansas City, Missouri, June 9-11, 1988. 16. Holmes, R.E.: Physiology of Bone and Bone Repair. AO/ASIF Basic Maxillofacial Course, The Association for the Study of Internal Fixation, Williamsburg, Virginia, October 20-22, 1988. 17. Holmes, R.E.: Biomechanics of Fracture Treatment. AO/ASIF Advanced Maxillofacial Course, The Association for the Study of Internal Fixation, Williamsburg, Virginia, October 20-22, 1988. 18. Holmes, R.E.: Bone Graft Substitutes and New Materials. AO/ASIF Advanced Maxillofacial Course, The Association for the Study of Internal Fixation, Williamsburg, Virginia, October 20-22, 1988. 19. Holmes, R.E.: Histometry of Autograft Incorporation and Remodeling. Third San Diego Bone Grafting Symposium, San Diego, California, December 1-4, 1988. 20. Holmes, R.E.: Histometry of Bone Graft Substitutes. Third San Diego Bone Grafting Symposium, San Diego, California, December 1-4, 1988. 21. Holmes, R.E.: Histometry of Osseointegration. Third San Diego Bone Grafting Symposium, San Diego, California, December 1-4, 1988. 22. Holmes, R.E.: Hydroxyapatite Implants and Bone Ingrowth. Bone Grafts and Bone Substitutes: From Basic Science to Clinical Applications, Tampa, Florida, January 26-28, 1989. Curriculum Vitae for Ralph E. Holmes, M.D. - 22

23. Holmes, R.E.: Fundamentals of Histometry for Bone Graft Substitutes. The Walter Reed Bone Symposium, Besthesda, Maryland, March 23-25, 1989. 24. Holmes, R.E.: Complications of Wound Healing. 11th Wound Management Workshop, San Diego, California, May 11-15, 1989. 25. Holmes, R.E.: Animal Bites. 11th Wound Management Workshop, San Diego, California, May 11-15, 1989. 26. Holmes, R.E.: Principles of Plating and Bone Healing. Maxillofacial Bone Plating Symposium, Santa Ana, California, May 19-20, 1989. 27. Holmes, R.E.: Overview of Rigid Internal Fixation and Biomechanics. Maxillofacial Bone Plating Symposium, Santa Ana, California, May 19-20, 1989. 28. Holmes, R.E.: Scientific Principles of Bone Plating. Maxillofacial Bone Plating Symposium, UCSD, San Diego, California, March 31, 1990. 29. Holmes, R.E., Rosenstein, D.A.: Quantitation of Osseointegration using Computerized Image Acquisition and Processing Techniques. UCLA Symposium on Implants in the Partially Edentulous Patient, Palm Springs, California, April 19-21, 1990. 30. Shors, E.C., Holmes, R.E., Kopchok, G.: Biodegradation and Bone Formation in Porous Ceramics. UCLA Symposium on Implants in the Partially Edentulous Patient, Palm Springs, California, April 19-21, 1990. 31. Holmes, R.E., Rosenstein, D.A.: Histometry of the Interface in Osseointegration. International Workshop on Osseointegration in Skeletal Reconstruction and Joint Replacement, Aruba, April 24-27, 1990. 32. Holmes, R.E.: Principles of Rigid Fixation in Maxillofacial Surgery. 6th Workshop on Advances in Dental Surgery, Department of Dentistry, Naval Hospital, San Diego, California, May 15, 1990. 33. Holmes, R.E.: Complications of Wound Healing. 12th Wound Management Workshop, San Diego, California, May 16-20, 1990. 34. Holmes, R.E.: Biomechanics of Bone Healing: Why Rigid Fixation. Maxillofacial Bone Plating Symposium, Loma Linda University Medical Center, Loma Linda, California, July 18, 1990. 35. Holmes, R.E.: Fracture Healing and Biomechanics. AO/ASIF Maxillofacial Workshop, University of California, San Francisco, California, January 11-12, 1991. Curriculum Vitae for Ralph E. Holmes, M.D. - 23

36. Holmes, R.E.: Mini Dynamic Compression Plates: Principles and Applications. AO/ASIF Maxillofacial Workshop, University of California, San Francisco, California, January 11-12, 1991. 37. Holmes, R.E.: Suture Techniques in Laceration Repair. 13th Wound Management Workshop, San Diego, California, May 16-18, 1991. 38. Holmes, R.E.: Bone Biology and Healing. AO/ASIF Maxillofacial Basic Course, San Diego, California, June 5-8, 1991. 39. Holmes, R.E.: Mini DCP Fixation for Mandible Fractures. AO/ASIF Maxillofacial Basic Course, San Diego, California, June 5-8, 1991. 40. Holmes, R.E.: Use of Microplates in Pfeiffer Syndrome. AO/ASIF Faculty Workshop, Colorado Springs, Colorado, June 20-23, 1991. 41. Holmes, R.E.: Fundamentals and Applications of Histometry for Assessing Bone Repair. Portland Bone Symposium 91, Portland, Oregon, July 17-20, 1991. 42. Holmes, R.E.: Suture Techniques in Laceration Repair. 14th Wound Management Workshop, San Diego, California, October 10-13, 1991. 43. Holmes, R.E.: Suture Techniques in Laceration Repair. 15th Wound Management Workshop, San Diego, California, May 7-10, 1992. 44. Holmes, R.E.: Relationship of Implant Design and Bone Type in Osseointegration. Review of 10 years of Osseointegration Workshop, Leesburg, Virginia, October 8-10, 1992. 45. Holmes, R.E.: Craniofacial Surgery and Midas Rex Certification Workshop. St. Louis University School of Medicine, St. Louis, Missouri, December 10-13, 1992. 46. Holmes, R.E.: Biology and Principles of Fracture Healing. AO/ASIF Maxillofacial Workshop. Naval Hospital, San Diego, California, March 25-26, 1993. 47. Holmes, R.E.: Suture Techniques in Laceration Repair. 15 th Wound Management Workshop, San Diego, California, May 13-16, 1993. 48. Holmes, R.E.: Current Concepts in Facial and Fracture Treatment: Plates and Screws for Newcomers and Oldtimers. Workshop at the 44th Annual Meeting of the California Society of Plastic Surgeons, San Diego, California, February 25 - March 1, 1994. Curriculum Vitae for Ralph E. Holmes, M.D. - 24

49. Holmes, R.E., Berger, J.S.: Timing and Nature of Surgical Interventions for Craniofacial Disorders, Mini Seminar on Reconstruction and Rehabilitation of the Child with a Handicapping Facial Deformity. Children s Hospital and Health Center, San Diego, California, March 18, 1994. 50. Holmes, R.E.: Pre-op Evaluation of Rhinoplasty. Presented to Division of Head and Neck Surgery, University of California, San Diego, California, April 1994. 51. Holmes, R.E.: Principles of Fracture Healing. Presented to Division of Head and Neck Surgery, University of California, San Diego, California, April 1994. 52. Holmes, R.E.: Principles of Mandibular Fracture Management. Presented to Division of Head and Neck Surgery, University of California, San Diego, California, April 1994. 53. Holmes, R.E.: Surgical Planning with Stereolithography Models - Craniofacial Surgeon s Wish List. Rapid Prototyping in Medicine, Milwaukee, Wisconsin, October 12-13, 1994 54. Holmes, R.E.: Suture Techniques in Laceration Repair. 16 th Wound Management Workshop, San Diego, California, May 12-15, 1994. 55. Glass, L.W., Holmes, R.E.: Endoscopy and Beyond. San Diego, California, September 23-24, 1994. 56. Holmes, R.E.: Suture Techniques in Laceration Repair. 16 th Wound Management Workshop, San Diego, California, October 12-15, 1994. 57. Virden, C.P., Holmes, R.E.: Endoscopic Facial Fracture Fixation. AO/ASIF Advanced Symposium on Craniomaxillofacial Reconstruction. Steamboat Springs, Colorado, January 14-17, 1995. 58. Glass, L.W., Holmes, R.E.: Endoscopic Plastic Surgery and Beyond. San Diego, California, February 11-12, 1995. 59. Holmes, R.E. AO/ASIF Maxillofacial Workshop for Residents. San Diego, California, April 8-9, 1995. 60. Glass, L.W., Holmes, R.E.: Endoscopic Plastic Surgery and Beyond. San Diego, California, April 29-30, 1995. 61. Glass, L.W., Holmes, R.E.: Endoscopic Plastic Surgery: The Next Step. Newport Beach, California, July 20, 1995. Curriculum Vitae for Ralph E. Holmes, M.D. - 25

62. Holmes, R.E.: Biocompatability and Biointegration of Bone Substitutes. American Society of Maxillofacial Surgeons, Montreal Canada, October 6, 1995. 63. Holmes, R.E.: Panel: Manufacturers and Clinicians Interface: New Directions and Strategies. American Society of Maxillofacial Surgeons, Montreal Canada, October 6, 1995. 64. Holmes, R.E.: Histometric Analysis of Biomaterials. New Concepts and Options in Bone Grafting. Education Design, Newport Beach, California, May 4, 1996. 65. Holmes, R.E.: AO/ASIF Maxillofacial Trauma & Reconstruction: Team Approach to Rigid Internal Fixation Techniques. University of Washington, Seattle, Washington, June 8-9, 1996. 66. Holmes, R.E.: Bone Grafting Options and The Ten Year Multi-Center Study Using Coralline Hydroxyapatite. Education Design, Pittsburgh, Pennsylvania, July 24, 1996. 67. Holmes, R.E.: AO/ASIF Maxillofacial Faculty Retreat. Lake George, New York, August 23-25, 1996. 68. Holmes, R.E.: Histometric Analysis of Biomaterials. New Concepts and Options in Bone Grafting. Education Design, New York, New York, October 12, 1996. 69. Holmes, R.E.: Augmentation of the Facial Skeleton in Aesthetic and Reconstructive Surgery. 65 th Anniversary Scientific Meeting, American Society of Plastic and Reconstructive Surgeons Inc., Dallas, Texas, November 9-13, 1996. 70. Holmes, R.E.: Histometric Analysis of Biomaterials. New Concepts and Options in Bone Grafting. Education Design, Northwestern University, Chicago, Illinois, November 23, 1996. 71. Holmes, R.E.: The Mandible. The Naval Hospital Workshop. AO/ASIF Maxillofacial Trauma & Reconstruction. San Diego, California, January 11, 1997. 72. Holmes, R.E.: Team Approach to Rigid Internal Fixation Techniques A Basic Course for Operating Room Personnel. AO/ASIF Maxillofacial Trauma & Reconstruction, Redondo Beach, California, March 8-9, 1997. 73. Holmes, R.E.: Histometric Analysis of Biomaterials. New Concepts and Options in Bone Grafting. Education Design, Chicago, Illinois, March 15, 1997. 74. Holmes, R.E.: Histometric Analysis of Biomaterials. New Concepts and Options in Bone Grafting. Education Design, Newport Beach, California, April 12, 1997. Curriculum Vitae for Ralph E. Holmes, M.D. - 26

75. Holmes, R.E.: Team Approach to Rigid Internal Fixation Techniques: A Basic Course for Operating Room Personnel. AO/ASIF Maxillofacial Trauma & Reconstruction, San Antonio, Texas, April 19, 1997. 76. Holmes, R.E.: Histometric Analysis of Biomaterials. New Concepts and Options in Bone Grafting. Education Design, Hilton Head, South Carolina, June 7, 1997. 75. Holmes, R.E.: Histometric Analysis of Biomaterials. New Concepts and Options in Bone Grafting. Education Design, Chicago, Illinois, August 16, 1997. 76. Holmes, R.E.: Histometric Analysis of Biomaterials. New Concepts and Options in Bone Grafting. Education Design, Chicago, Keystone, Colorado, December 6, 1997. 77. Holmes, R.E.: Basic Science of Ceramic Forms of Hydroxyapatite. Biomaterials in the Face. PSEF/ASMS Workshop, Boston, Massachusetts, October 2, 1998. 78. Holmes, R.E.: Porous Ceramics and Bone Regeneration. Portland Bone Symposium 99, Portland, Oregon, August 4-7, 1999. 79. Holmes, R.E.: Biology of Distraction An Experimental Perspective. Surgery in the New Millenium: Distraction Osteogenesis of the Cranio-Maxillofacial Skeleton, San Diego, California, October 16, 1999. 80. Holmes, R.E.: Biology of Protected Bone Regeneration. American Association of Pediatric Plastic Surgeons, New Orleans, Louisiana, October 24, 1999. 81. Holmes, R.E., Cohen, S.R.: Protected Bone Regeneration: A New Technology for the New Millenium. 31 st Annual Cleft Palate and Craniofacial Anomalies Symposium: Facing the New Millennium with High Tech Advances in Cleft Care, Saint John s Health Center, Santa Monica, California, November 6, 1999. 82. Cohen, S.R., Holmes, R.E.: Internal Craniofacial Distraction with a Modular System. 31 st Annual Cleft Palate and Craniofacial Anomalies Symposium: Facing the New Millennium with High Tech Advances in Cleft Care, Saint John s Health Center, Santa Monica, California, November 6, 1999. 83. Holmes, R.E., Cohen, S.R.: Resorbable Fixation in Craniofacial Reconstruction Surgery. The New Jersey Federation of Cleft Palate/Craniofacial Centers Annual Symposium, Saint Barnabas Medical Center, Livingston, New Jersey, March 25, 2000. 84. Holmes, R.E., Cohen, S.R.: Clinical Applications and Experience with Reabsorbable Fixation in Craniofacial Reconstruction. San Diego Neurosurgical Society, San Diego, California, March 29, 2000. Curriculum Vitae for Ralph E. Holmes, M.D. - 27

85. Cohen, S.R., Holmes, R.E.: Clinical Experience with Internal Distraction in Craniofacial Reconstruction. San Diego Neurosurgical Society, San Diego, California, March 29, 2000. 86. Holmes, R.E.: Recent Developments in Bone Implants and Fixation. Advances in Mineral Metabolism, American Society of Bone Mineral Research, Snowmass, Colorado, March 29-April 1, 2000. 87. Holmes, R.E., Cohen, S.R.: New Techniques in Craniofacial Reconstruction using Resorbable Devices. San Diego Oral and Maxillofacial Surgery Society, San Diego, California, April 6, 2000. 88. Cohen, S.R., Holmes, R.E.: New Techniques in Internal Distraction for Craniofacial Reconstruction. San Diego Oral and Maxillofacial Surgery Society, San Diego, California, April 6, 2000. 89. Holmes, R.E., Cohen, S.R.: New Techniques in Craniofacial Reconstruction using Resorbable Devices. Orange County Society of Neurological Surgeons, Newport Beach, California, June 17, 2000. 90. Cohen, S.R., Holmes, R.E.: New Techniques in Internal Distraction for Craniofacial Reconstruction. Orange County Society of Neurological Surgeons, Newport Beach, California, June 17, 2000. 91. Cohen, S.R., Holmes, R.E.: Differential Diagnosis of Skull Deformities. Pediatric Skull Deformities Mini-Seminar, Children s Hospital and HealthCare Center, San Diego, California, August 12, 2000. 92. Holmes, R.E., Cohen, S.R.: New Biodegradable Devices for Craniofacial Fixation. Pediatric Skull Deformities Mini-Seminar, Children s Hospital and HealthCare Center, San Diego, California, August 12, 2000. 93. Holmes, R.E., Cohen, S.R.: Biologic Concepts of Resorbable Fixation and Protected Bone Regeneration. Symposium on Resorbable Devices in Craniomaxillofacial Surgery: New Techniques in Bone Fixation, Protection and Distraction. Children s Hospital and HealthCare Center, San Diego, California, August 26, 2000. 94. Cohen, S.R., Holmes, R.E.: Pediatric Craniofacial Surgery Using Resorbable Devices and Tacks. Symposium on Resorbable Devices in Craniomaxillofacial Surgery: New Techniques in Bone Fixation, Protection and Distraction. Children s Hospital and HealthCare Center, San Diego, California, August 26, 2000. Curriculum Vitae for Ralph E. Holmes, M.D. - 28

95. Holmes, R.E., Cohen, S.R.: Biologic Fixation of Post-Traumatic Deformities: In Situ Contouring, Telecanthus Correction, and Nasal Bone Graft Techniques. Symposium on Resorbable Devices in Craniomaxillofacial Surgery: New Techniques in Bone Fixation, Protection and Distraction. Children s Hospital and HealthCare Center, San Diego, California, August 26, 2000. 96. Cohen, S.R., Holmes, R.E.: Craniofacial Distraction with Biodegradable Devices. Symposium on Resorbable Devices in Craniomaxillofacial Surgery: New Techniques in Bone Fixation, Protection and Distraction. Children s Hospital and HealthCare Center, San Diego, California, August 26, 2000. 97. Holmes, R.E.: Ear Reconstruction for Microtia. Seminar on Current Concepts in the Mangement of Craniofacial Disorders. Children s Hospital and HealthCare Center, San Diego, California, October 27, 2000. 98. Cohen, S.R., Holmes, R.E., Meltzer, H.: Internal Craniofacial Distraction in the Treatment of Syndromic Craniosynostosis. Craniofacial Distraction Osteogenesis: Current Techniques and Future Directions. Baylor College of Dentistry, Texas A&M University System Health Science Center, Dallas, Texas, November 10-12, 2000. 99. Holmes, R.E., Cohen, S.R.: Biologic Concepts of Resorbable Fixation and Protected Bone Regeneration. Symposium on Resorbable Devices in Craniomaxillofacial and Neurosurgery: New Techniques in Bone Fixation, Protection and Distraction. Columbia University College of Physicians & Surgeons, New York, New York, December 2, 2000. 100. Cohen, S.R., Holmes, R.E.: Pediatric Craniofacial Surgery Using Resorbable Devices and Tacks. Symposium on Resorbable Devices in Craniomaxillofacial and Neurosurgery: New Techniques in Bone Fixation, Protection and Distraction. Columbia University College of Physicians & Surgeons, New York, New York, December 2, 2000. 101. Holmes, R.E., Cohen, S.R.: New Techniques for Skeletal and Soft Tissue Contour Correction. Symposium on Resorbable Devices in Craniomaxillofacial and Neurosurgery: New Techniques in Bone Fixation, Protection and Distraction. Columbia University College of Physicians & Surgeons, New York, New York, December 2, 2000. 102. Cohen, S.R., Holmes, R.E.: Craniofacial Distraction with Biodegradable Devices. Symposium on Resorbable Devices in Craniomaxillofacial and Neurosurgery: New Techniques in Bone Fixation, Protection and Distraction. Columbia University College of Physicians & Surgeons, New York, New York, December 2, 2000. Curriculum Vitae for Ralph E. Holmes, M.D. - 29

103. Holmes, R.E.: Bone Grafting Options and Substitutes. 17 th International Symposium on Bone growth Factors and Substitutes: The Next Generation. Educational Design, Vail, Colorado, December 9, 2000. 104. Holmes, R.E.: Bone Grafting Options and Substitutes. 17 th International Symposium on Bone growth Factors and Substitutes: Spinal Procedures and Fusions. Educational Design, Vail, Colorado, December 10, 2000. 105. Cohen, S.R., Holmes, R.E.: Guided Bone Regeneration. Craniofacial Surgery: The New Millenium. ASMS/PSEF Craniofacial Symposium, New York City, New York, March 29 April 1, 2001. 106. Holmes, R.E., Cohen, S.R.: Resorbable Polymers: Their Properties and Biologic Behavior. Forum on Paediatric Facial Disorders, Department of Plastic and Maxillofacial Surgery, Royal Children s Hospital, Melbourne, Victoria, Australia, August 31, 2001. 107. Holmes, R.E., Cohen, S.R.: Clinical Review of Resorbable Fixation in CMF, Neurosurgical and Orthopedic Applications. Forum on Paediatric Facial Disorders, Department of Plastic and Maxillofacial Surgery, Royal Children s Hospital, Melbourne, Victoria, Australia, August 31, 2001. 108. Cohen, S.R., Holmes, R.E.: Neonatal Mandibular Distraction for Obstructive Sleep Apnea. Forum on Paediatric Facial Disorders, Department of Plastic and Maxillofacial Surgery, Royal Children s Hospital, Melbourne, Victoria, Australia, August 31, 2001. 109. Cohen, S.R., Holmes, R.E.: Internal Craniofacial Distraction for Midface and Frontal Advancement. Forum on Paediatric Facial Disorders, Department of Plastic and Maxillofacial Surgery, Royal Children s Hospital, Melbourne, Victoria, Australia, August 31, 2001. 110. Holmes, R.E., Cohen, S.R.: Pediatric Craniofacial Surgery using Mesh and Tacks. Forum on Paediatric Facial Disorders, Department of Plastic and Maxillofacial Surgery, Royal Children s Hospital, Melbourne, Victoria, Australia, August 31, 2001. 111. Cohen, S.R., Holmes, R.E.: Endoscopic Assisted Treatment of Craniosynostosis with Immediate Reconstruction. Forum on Paediatric Facial Disorders, Department of Plastic and Maxillofacial Surgery, Royal Children s Hospital, Melbourne, Victoria, Australia, August 31, 2001. Curriculum Vitae for Ralph E. Holmes, M.D. - 30

112. Holmes, R.E., Cohen, S.R.: Tissue Engineering: When Will We Get There? Forum on Paediatric Facial Disorders, Department of Plastic and Maxillofacial Surgery, Royal Children s Hospital, Melbourne, Victoria, Australia, August 31, 2001. 113. Holmes, R.E., Cohen, S.R.: Soft Tissue Contour Correction using PLA Mesh. Forum on Paediatric Facial Disorders, Department of Plastic and Maxillofacial Surgery, Royal Children s Hospital, Melbourne, Victoria, Australia, August 31, 2001. 114. Cohen, S.R., Holmes, R.E.: Craniofacial Distraction: State of the Art. PSEF Symposium on Aesthetic Facial Reconstruction, Nashville, TN, February 16, 2002. 115. Holmes, R.E.: Properties and Biology of Resorbable Fixation. AO ASIF Principles of Operative Treatment of Craniomaxillofacial Trauma and Reconstruction. AO North America, The Westin Convention Center, Pittsburgh, Pennsylvania, March 23-24, 2002. (Co-chairman) 116. Holmes, R.E.: Clinical Review of Resorbable Fixation. AO ASIF Principles of Operative Treatment of Craniomaxillofacial Trauma and Reconstruction. AO North America, The Westin Convention Center, Pittsburgh, Pennsylvania, March 23-24, 2002. (Co-chairman) 117. Cohen, S.R., Holmes R.E.: Craniofacial and Midface Distraction. Panel on Craniofacial Distraction: The First Decade. American Association of Plastic Surgeons, Seattle, Washington, April 28, 2002. 118. Cohen S.R., Holmes R.E.: New Innovations in Pediatric Plastic and Craniofacial Surgery. Kaiser Permanente. Plastic Surgery Symposium. L Auberge Resort, Del Mar, CA, May 18, 2002. 119. Cohen S.R., Holmes R.E.: Invited Speaker, Pavel Symposium of Oral and Maxillofacial Surgery- Selected Advances in Craniofacial Surgery, San Diego, California, September 14, 2002. Curriculum Vitae for Ralph E. Holmes, M.D. - 31

PRESENTATIONS AT SCIENTIFIC AND SOCIETY MEETINGS 1. Kirchner, J.A., Cornog, J.L., Holmes, R.E.: Transglottic cancer: its growth and spread within the larynx. Presented at the Joint Meeting of the Society of Head and Neck Surgeons and the American Society for Head and Neck Surgery, Hot Springs, Virginia, May 1-4, 1973. 2. Smith, H.W., Holmes, R.E.: Congenital choanal atresia - surgical correction. Presented at the 79th Annual Meeting of the American Academy of Ophthalmology and Otolaryngology, Dallas, Texas, October 6-10, 1974.3 3. Holmes, R.E., Sallis, J., Johns, D.F., Salyer, K.E.: Major Craniofacial Surgery. Exhibited at the Interdisciplinary Conference for the Evaluation of Recent Advances in Craniofacial Surgery, Center for Craniofacial Anomalies, University of Illinois Medical Center, Chicago, Illinois, November 8-10, 1974. 4. Holmes, R.E., Sallis, J., Johns, D.F., Salyer, K.E.: Complications of Major Craniofacial Surgery: The Dallas Experience. Presented at the Interdisciplinary Conference for the Evaluation of Recent Advances in Craniofacial Surgery, Center for Craniofacial Anomalies, University of Illinois Medical Center, Chicago, Illinois, November 8-10, 1974. 5. Salyer, K.E., Johns, D.F., Holmes, R.E., Layton, J.G.: Evolution of the mandibular mesh implant. Presented at the 7th Annual International Biomaterials Symposium, Clemson, South Carolina, April 26-30, 1975. (Presenter) 6. Holmes, R.E., Salyer, K.E., Johns, D.F., Layton, J.G.: Reconstruction of mandibular continuity defects in dogs with replamineform hydroxyapatite and titania. Presented at the 8th Annual International Biomaterials Symposium, Philadelphia, Pennsylvania, April 9-13, 1976. 7. Holmes, R.E., Salyer, K.E., Layton, J.G., Tarhay, L.: Fabrication of a porous implant and fixation device for the regeneration of mandibular continuity defects in dogs. Presented at the 24th Annual Meeting of the American Academy of Maxillofacial Prosthetics, San Diego, California, November 7-10, 1976. 8. Holmes, R.E., Salyer, K.E., Tarhay, L., White, E.W.: Reconstruction of the canine mandible with replamineform hydroxyapatite. Presented at the 9th Annual International Biomaterials Symposium, New Orleans, Louisiana, April 15-19, 1977. 9. Salyer, K.E., Johns, D.F., Holmes, R.E. Spectrum of Craniofacial Surgery. Exhibited at the 3rd International Congress on Cleft Palate and Other Craniofacial Anomalies, Toronto, Canada, May, 1977. Curriculum Vitae for Ralph E. Holmes, M.D. - 32

10. Salyer, K.E., Johns, D.F., Holmes, R.E. Spectrum of Craniofacial Surgery. Exhibited at the Annual American Medical Association Convention, San Francisco, California, June, 1977. 11. Salyer, K.E., Holmes, R.E., Johns, D.F.: Replamineform porous hydroxyapatite as a bone substitute in craniofacial osseous reconstruction. Presented at the Annual General Session, American Association for Dental Research, Las Vegas, Nevada, June 23-26, l977. (Presenter) 12. Salyer, K.E., Newsom, H.T., Holmes, R.E., Hahn, G.: Mandibular reconstruction. Presented to the Society of Head and Neck Surgeons, Hilton Head, South Carolina, May 4-7, 1977. 13. Holmes, R.E. Reconstruction of the canine mandible with a coral microstructure implant. Presented at the 17th Annual Plastic Surgery Senior Residents' Conference, Hershey, Pennsylvania, April 9-12, 1978. 14. Holmes, R.E., Salyer, K.E.: Bone regeneration in a coralline hydroxyapatite implant. Presented to the 23rd Annual Meeting of the Plastic Surgery Research Council, Richmond, Virginia, May 25-27, 1978. 15. Holmes, R.E., Salyer, K.E.: Bone regeneration in a coralline hydroxyapatite implant. Presented to the Forum on Surgical Problems, 64th Annual Clinical Congress, American College of Surgeons, San Francisco, California, October 16-20, 1978. 16. Holmes, R.E., Salyer, K.E.: Bone regeneration in a coralline hydroxyapatite implant. Presented to the 47th Annual Scientific Meeting of the American Society of Plastic and Reconstructive Surgeons, Hollywood, Florida, November 5-10, 1978. 17. Holmes, R.E.: Hydroxyapatite Update. Presented to the 24th Annual Meeting of the Plastic Surgery Research Council, Dallas, Texas, April 8-11, 1979. 18. Bucholz, R.W., Holmes, R.E., Mooney, V.: Regeneration of Articular Cartilage over Coralline Hydroxyapatite. Exhibited at the 27th Annual Meeting, Orthopaedic Research Society, Society, Las Vegas, Nevada, February 24-26, 1981. 19. Holmes, R.E., Bucholz, R.W., Mooney, V.: Coralline Hydroxyapatite - A Potential Bone Graft Substitute. Exhibited at the 48th Annual Meeting, American Academy of Orthopaedic Surgeons, Las Vegas, Nevada, February 26 - March 3, 1981. Curriculum Vitae for Ralph E. Holmes, M.D. - 33

20. Holmes, R.E.: What does periosteum contribute to bone regeneration? Presented to the 26th Annual Meeting of the Plastic Surgery Research Council, Springfield, Illinois, May 21-23, 1981. 21. Springer, W.T., Lawrence, K.L., Mooney, V., Holmes, R.E.: Fracture healing assessment via structural frequency. Presented to the 34th Annual Conference on Engineering in Medicine and Biology, Houston, Texas, September 19-21, 1981. 22. Holmes, R.E.: Does implant architecture influence the morphology of bone regeneration? Presented to the 27th Annual Meeting of the Plastic Surgery Research Council, San Diego, California, March 14-17, 1982. 23. Holmes, R.E., Tencer, A.F., Carmichael, T.W., Mooney, V.: Mechanical properties of synthetic hydroxyapatite for cancellous bone grafting. Presented to the 29th Annual Meeting of the Orthopaedic Research Society, Anaheim, California, March 8-10, 1983. 24. Holmes, R.E.: The physiology of heterotopic bone formation. Presented to the 15th Annual Meeting of the American Burn Association, New Orleans, Louisiana, March 16-19, 1983. 25. Holmes, R.E., Tencer, A.F., Carmichael, T.W., Mooney, V.: Mechanical properties of synthetic hydroxyapatite for cancellous bone grafting. Presented to the 18th Annual Meeting of the Association for the Advancement of Medical Instrumentation, Dallas, Texas, May 22-25, 1983. 26. Holmes, R.E., Mooney, V.: Stereology of bone regeneration in a synthetic HA implant. Presented to the 30th Annual Meeting of the Orthopaedic Research Society, Atlanta, Georgia, February 6-9, 1984. 27. Tencer, A.F., Bucholz, R.W., Holmes, R.E.: Analysis of variable stiffness external fixation. Presented to the 30th Annual Meeting of the Orthopaedic Research Society, Atlanta, Georgia, February 6-9, 1984. 28. Holmes, R.E.: Histomorphometry of bone regeneration in implant and graft treated radius defects. Presented to the 29th Annual Meeting of the Plastic Surgery Research Council, Detroit, Michigan, April 2-4, 1984. 29. Holmes, R.E., Mooney V.: Bone regeneration in canine radius defects treated by coralline implants and iliac grafts. Presented to the 2nd World Congress on Biomaterials and the 10th Annual Meeting of the Society for Biomaterials, Washington, D.C., April 27 - May 1, 1984. Curriculum Vitae for Ralph E. Holmes, M.D. - 34

30. Schoenaers, J.H., Holmes, R.E., Finn, R.A., Bell, W.H.: Hydroxylapatite vs. autogenous bone for canine interpositional mandibular augmentation: long term histology and histomorphometry. Presented to the 66th Annual Meeting of the American Association of Oral and Maxillofacial Surgeon, New York, New York, September 14-18, 1984. 31. Holmes, R.E., Mooney, V.: Bone regeneration in a cancellous hydroxyapatite implant. Presented to the Forum on Surgical Problems, 70th Annual Clinical Congress, American College of Surgeons, San Francisco, California, October 21-26, 1984. 32. Bucholz, R.W., Holmes, R.E., Mooney, V.: Porous Hydroxyapatite as a Bone Graft Substitute in Long Bone Traumatic Defects. Exhibited at the 52nd Annual Meeting, American Academy of Orthopaedic Surgeons, Las Vegas, Nevada, January 22-27, 1985. 33. Schoenaers, J.H., Holmes, R.E., Finn, R.A., Bell, W.H.: Healing in interconnected porous hydroxylapatite blocks: long term histology and histomorphometry. Presented to the 11th Annual Meeting of the Society for Biomaterials, San Diego, California, April 25-28, 1985. 34. Schoenaers, J.H., Holmes, R.E., Finn, R.A., Bell, W.H.: Healing in interconnected porous hydroxylapatite blocks: long term histology and histomorphometry. Presented to the International Meeting on Tissue Integration, Brussels, Belgium, May 22-25, 1985. 35. Holmes, R.E., Hagler, H.K.: Mandible contour augmentation: autograft vs. porous HA implant. Presented to the 67th Annual Meeting of the American Association of Oral and Maxillofacial Surgeons, Washington DC, October 3-7, 1985. 36. Bucholz, R.W., Holmes, R.E., Mooney, V.: Synthetic hydroxyapatite as a bone graft substitute in traumatic defects of long bones. Presented to the 53rd Annual Meeting of the American Academy of Orthopaedic Surgeons, New Orleans, Louisiana, February 20-25, 1986. 37. Sartoris, D.J., Holmes, R.E., Resnick, D.: Coralline hydroxyapatite bone graft substitutes in a canine diaphyseal defect model: radiographic features of failed and successful union. Presented to the 34th Annual Meeting of the Association of University Radiologists, Hartford, Connecticut, May 4-9, 1986. 38. Sartoris, D.J., Holmes, R.E., Bucholz, R.W., Mooney, V., Resnick, D.: Coralline hydroxyapatite bone graft substitutes in a canine metaphyseal defect model: radiographic-histometric correlation. Presented to the 34th Annual Meeting of the Association of University Radiologists, Hartford, Connecticut, May 4-9, 1986. Curriculum Vitae for Ralph E. Holmes, M.D. - 35

39. Holmes, R.E.: Cranial reconstruction with porous hydroxyapatite implants and split rib autografts: a histometric study. Presented to the 31st Annual Meeting of the Plastic Surgery Research Council, Norfolk, Virginia, May 18-21, 1986. 40. Holmes, R.E., Hagler, H.K.: Maxillary contour augmentation: porous HA vs. autograft. Presented to the 9th International Conference on Oral and Maxillofacial Surgery, Vancouver, B.C., May 21-25, 1986. 41. Schoenaers, J.H., Holmes, R.E., Finn, R.A., Bell, W.H.: Healing in interconnected porous hydroxylapatite blocks: a long term histologic and histomorphometric study. Presented to the 9th International Conference on Oral and Maxillofacial Surgery, Vancouver, B.C., May 21-25, 1986. (Presenter) 42. Holmes, R.E., Hagler, H.K.: Maxillofacial augmentation: porous HA vs autograft. Presented to the 12th Annual Meeting of the Society for Biomaterials in conjunction with the 18th International Biomaterials Symposium, Minneapolis, Minnesota, May 28 - June 1, 1986. 43. Shimizu, T., Videman, T., Zerwekh, J.E., Mooney, V., Holmes, R.E., Hagler, H.K.: The effect of pulsed electromagnetic fields on bone ingrowth into implants. Presented to the 12th Annual Meeting of the Society for Biomaterials in conjunction with the 18th International Biomaterials Symposium, Minneapolis, Minnesota, May 28 - June 1, 1986. 44. Holmes, R.E., Hagler, H.K.: Craniofacial reconstruction and maxillofacial contour augmentation with porous HA and split rib autografts. Presented to the 68th Annual Meeting of the American Association of Oral and Maxillofacial Surgeons, New Orleans, September 24-28, 1986. 45. El Deeb, M., Templeton, R.B., Holmes, R.E.: Zygomatic and mandibular augmentation with Proplast and porous hydroxylapatite material in monkeys. Presented to the 68th Annual Meeting of the American Association of Oral and Maxillofacial Surgeons, New Orleans, Louisiana, September 24-28, 1986. 46. Holmes, R.E., Hagler, H.K.: Cranial reconstruction with porous hydroxyapatite implants and split rib autografts. Presented to the 42nd Annual Forum on Surgical Problems, 72nd Annual Clinical Congress, American College of Surgeons, New Orleans, Louisiana, October 19-24, 1986. 47. Holmes, R.E., Hagler, H.K.: Craniofacial reconstruction with porous HA implants and bone autografts. Presented to the 55th Annual Scientific Meeting of the American Society of Plastic and Reconstructive Surgeons, Los Angeles, California, October 26-31, 1986. Curriculum Vitae for Ralph E. Holmes, M.D. - 36

48. Shimizu, T., Zerwekh, J.E., Videman, T., Holmes, R.E., Mooney, V.: The effect of pulsing electromagnetic field on bone ingrowth into porous calcium ceramics. Presented to the 33rd Annual Meeting of the Orthopaedic Research Society, San Francisco, California, January 19-22, 1987. 49. El Deeb, M.E., Holmes, R.E.: Facial augmentation with Proplast and porous hydroxylapatite material in primates. Presented to the 65th General Session of the International Association for Dental Research, Chicago, Illinois, March 11-15, 1987. 50. Holmes, R.E.: Thick section histometry of porous hydroxyapatite implants using backscattered electron imaging. Presented to the 2nd International Congress on Preprosthetic Surgery, Palm Springs, California, May 14-16, 1987. 51. Lavernia, C., Akeson, W.A., Holmes, R.E.: Current Status of Ceramic Implants in Orthopaedic Surgery. Exhibited at the 34th Annual Meeting, Orthopaedic Research Society, Atlanta, Georgia, February 1-4, 1988. 52. Holmes, R.E.: The histometry of osseointegration. Presented to the 3rd Annual Meeting of the Academy of Osseointegration, Dallas, Texas, March 4-5, 1988. 53. Holmes, R.E., LaBorde, R.T., Kitabayashi, L.R.: Automated morphometry of tetracycline labeled bone with scanning electron microscope cathodoluminescence. Presented to the 5th International Congress on Bone Morphometry, Niigata, Japan, July 24-29, 1988. 54. Holmes, R.E., LaBorde, R.T., Kitabayashi, L.R.: Automated morphometry of tetracycline labeled bone with scanning electron microscope cathodoluminescence. Exhibited at the 5th International Congress on Bone Morphometry, Niigata, Japan, July 24-29, 1988. 55. El Deeb, M., Holmes, R.E.: Facial contour augmentation with dense and porous hydroxylapatite in Rhesus monkeys. Presented to the 70th Annual Meeting of the American Association of Oral and Maxillofacial Surgeons, Boston, Massachusetts, September 28-October 2, 1988. 56. Fisher, J.C., Frank, D.F., Holmes, R.E.: What's New in Reconstructive Surgery. Presented to the 20th National Congress of the Mexican Association of Plastic Surgeons, Tijuana, B.C.N., February 22-26, 1989. (Presenter) 57. Holmes, R.E.: Histometry of BSE Images. Presented to the Scanning Microscopy Society, Salt Lake City, Utah, May 1-5, 1989. Curriculum Vitae for Ralph E. Holmes, M.D. - 37

58. Gross, H.N., Holmes, R.E.: Surgical retrieval and histologic evaluation of an endosteal implant. Presented to the 19th International Dental Implantology Meeting of the G.I.S.I., Bologna, Italy, May 26-28, 1989. 59. Holmes, R.E., Shors, E.C., Kopchok, G., Kitabayashi, L.R., LaBorde, R.T.: Effect of implant biodegradation rate on bone repair. Exhibited at the 36th Annual Meeting, Orthopaedic Research Society, New Orleans, Louisiana, February 5-8, 1990. 60. Holmes, R.E., Shors, E.C., Kopchok, G., Kitabayashi, L.R., LaBorde, R.T.: Effect of implant biodegradation rate on bone repair. Presented to the 68th General Session of the International Association for Dental Research, Cincinnati, Ohio, March 7-11, 1990. 61. Holmes, R.E., Shors, E.C., Kopchok, G., Kitabayashi, L.R., LaBorde, R.T.: Effect of implant biodegradation rate on bone repair. Presented to the 16th Annual Meeting of the Society for Biomaterials, Charleston, South Carolina, May 20-23, 1990. 62. Sullivan, P.K., Rosenstein, D.A., Craig, D., Holmes, R.E.: Treatment of large orbital floor defects with plate supported bone grafts: a monkey study. Presented to the 59th Annual Meeting of the American Society of Plastic and Reconstructive Surgeons, Boston, Massachusetts, October 21-26, 1990. 63. Holmes, R.E.: Academic and Biotech Research: A Tale of Two Cultures. Presented at the Annual Meeting of the Southern California Chapter of the American College of Surgeons, San Diego, California, January 18-20, 1991. 64. Rosenstein, D.A., Holmes, R.E.: A histometric and biomechanical comparison of cancellous autografts and xenografts in a beagle tibial defect. Presented at the Annual Meeting of the Southern California Chapter of the American College of Surgeons, San Diego, California, January 18-20, 1991. 65. Nelson, J.M., Holmes, R.E., Fisher, J.F., Armstrong, D.A.: Management of mandibular fractures in a public institutional practice. Presented to the 41st Annual Meeting of the California Society of Plastic Surgeons, San Francisco, California, March 2-6, 1991. 66. Rosenstein, D.A., Sullivan, P.K., Holmes, R.E., Manson, P.K.: Bone graft reconstruction of monkey orbital floor with iliac grafts and titanium mesh plate: a histometric study. Presented to the 41st Annual Meeting of the California Society of Plastic Surgeons, San Francisco, California, March 2-6, 1991. Curriculum Vitae for Ralph E. Holmes, M.D. - 38

67. Rosenstein, D.A., Holmes, R.E., Kitabayashi, L.R.: A histometric and biomechanical comparison of cancellous autografts and xenografts in a beagle tibial defect. Presented to the 37th Annual Meeting of the Orthopaedic Research Society, Anaheim, California, March 4-7, 1991. 68. Shors, E.C., Kopchok, G., Holmes, R.E., Rosenstein, D.A., Bumbalough, T.: Biodegradation of porous hydroxyapatite/calcium carbonate implants in rabbits. Presented to the 37th Annual Meeting of the Orthopaedic Research Society, Anaheim, California, March 4-7, 1991. 69. Shors, E.C., Rosenstein, D., Holmes, R., Kopchok, G.: The use of porous hydroxyapatite with dental implants in rabbit tibiae. Presented to the 4th International Congress on Preprosthetic Surgery, Palm Springs, CA, April 18-20, 1991. 70. Kraut, R.A., Dootson, J., Holmes, R.: Osseous ingrowth into porous hydroxyapatite. Presented to the 4th International Congress on Preprosthetic Surgery, Palm Springs, CA, April 18-20, 1991. 71. Shors, E.C., Rosenstein, D., Holmes, R., Kopchok, G.: The use of porous hydroxyapatite granules with dental implants. Presented to the 17th Annual Meeting of the Society for Biomaterials, Scottsdale, Arizona, May 1-5, 1991. 72. Rosenstein, D.A., Holmes, R.E., Campbell, T.D.: Comparison of autograft and xenograft in a tibial defect: a histometric and biomechanical study. Exhibited at 17th Annual Meeting of the Society for Biomaterials, Scottsdale, Arizona, May 1-5, 1991. 73. Shors, E.C., Rosenstein, D., Holmes, R., Kopchok, G., Bumbalough, T.: The material and in vivo properties of a biodegradable bone graft substitute. Presented to the 17th Annual Meeting of the Society for Biomaterials, Scottsdale, Arizona, May 1-5, 1991. 74. Rosenstein, D.A., Holmes, R.E.: A histometric and biomechanical comparison of cancellous autografts and xenografts in a canine tibial defect. Presented to the 36th Annual Meeting of the Plastic Surgery Research Council, Charlottesville, Virginia, May 5-8, 1991. 75. Le, H.M., Holmes, R.E., Rosenstein, D.A., Shors, E.C.: Computerized quantitative analysis of porous substrates. Exhibited at the Eighth International Congress for Stereology, Irvine, California, August 25-29, 1991. Curriculum Vitae for Ralph E. Holmes, M.D. - 39

76. Rosenstein, D.A., Holmes, R.E.: A histometric and biomechanical comparison of cancellous autografts and xenografts in a beagle tibial defect. Presented to the 77th Clinical Congress of the American College of Surgeons, Orthopaedic Forum, Chicago, Illinois, October 20-25, 1991. 77. Kitabayashi, L.R., Holmes, R.E., Rosenstein, D.A.: New technological advances in the preparation and sectioning of hard tissue specimens. Exhibited at the Second Undecalcified Bone Symposium, Indianapolis, Indiana, October 25-26, 1991. 78. Rosenstein, D.A., Holmes, R.E.: Biodegradation of porous hydroxyapatite. Presented at the Annual Meeting of the Southern California Chapter of the American College of Surgeons, Indian Wells, California, January 19-20, 1992. 79. Weinlaender, M., Plenk, H., Adar, F., Holmes, R: TCP-impurities in HA granules and crystallinity changes in plasma flame sprayed HA coatings detected by spectroscopical methods and their consequences. Presented to the International Congress on Bioceramics and the Human Body, Faenza, Italy, April 2-5, 1992. 80. Le, H.M., Holmes, R.E., Shors, E.C., Rosenstein, D.A.: Computerized analysis of porous HA implants. Presented to the 2nd UCLA Symposium on Implants in the Partially Edentulous Patient, Palm Springs, California, May 7-9, 1992. 81. Cooper, M.L., Nelson, J.M., Holmes, R.E.: Optimizing the surgical management of mandibular fractures. Presented to the 43 rd Annual Meeting of the California Society of Plastic Surgeons, Inc. Monterey, California, February 26 - March 1, 1993. 82. Holmes, R.E.: An alternative bone graft study: fydroxyapatite granules vs. autogeneous bone graft incorporation in a large skeletal defect. Presented to the Orthopedic Academy, San Francisco, California, 1993. 83. Glass, L.W., Holmes, R.E., Berger, J.S.: Elective Maxillary Osteotomy: Another Indication for Subperiosteal Facelift. Presented to the 44th Annual Meeting of the California Society of Plastic Surgeons, San Diego, California, February 25 - March 1, 1994. 84. Holmes, R.E., Berger, J.S., James, H., Jones, M.: Microtia - Educating the Parents Using a Multimedia Presentation. Exhibited at the 51st Annual Meeting of the American Cleft Palate-Craniofacial Association, Toronto, Ontario, May 16-21, 1994. 85. Glass, L.W., Holmes, R.E., Berger, J.S.: Elective Maxillary Osteotomy: Another Indication for Subperiosteal Facelift. Presented to the 1994 International Symposium on Plastic Surgery, Florence, Italy, May 21-24, 1994. Curriculum Vitae for Ralph E. Holmes, M.D. - 40

86. Calhoun, C.J., Lemperle, S.M., Holmes, R.E. Quantitative Analysis of Dental Implant Osseointegration Using Histometric Image Processing. Exhibited at the International Dental Implant Symposium, San Diego, California, November 17-18, 1995. 87. Lemperle, S.M., Calhoun, C.J., Curran, R.W., Holmes, R.E. The Osteoconductive Effect of Coralline Hydroxyapatite on Large Cranial and Mandibular Defects in Dogs. Presented to the Annual Scientific Meeting of the Southern California Chapter of the American College of Surgeons, Santa Barbara, California, January 19-21, 1996. 88. D Lima, D.D., Lemperle, S.M., Holmes, R.E., Colwell, C.W. Bone Response to Implant Surface Morphology. Presented to the 42 nd annual meeting, Orthopaedic Research Society, Atlanta, Georgia, February 19-22, 1996. 89. Lemperle, S.M., Calhoun, C.J., Curran, R.W., Holmes, R.E. Comparison of Protected Bone Regeneration, Osteoconduction with Coralline Hydroxyapatite Implants and Cancellous Bone Autografts in Large Cranial and Mandibular Defects in Dogs. Presented and exhibited at the 41 st Annual Meeting of the Plastic Surgery Research Council, St. Louis, Missouri, June 1-4, 1996. 90. Lemperle, S.M., Calhoun, C.J., Curran, R.W., Holmes, R.E. Comparison of Protected Bone Regeneration, Osteoconduction with Coralline Hydroxyapatite Implants and Cancellous Bone Autografts in Large Cranial and Mandibular Defects in Dogs. Presented to the 82 nd Clinical Congress of the American College of Surgeons, San Francisco, California, October 6-11, 1996. 91. Miller, S.R., Batra, M.K., Holmes, R.E., Cooper, M.L. Conjoined Twins, Tissue Expanders and Videotape. Presented to American College of Surgeons, Southern California Chapter, Dana Point California, January 17-19, 1997. 92. Lemperle, S., Calhoun, C., Curran, W., Massie, J., Holmes, R.: Protected Bone Regeneration: A New Concept in Facilitating the Healing of Large Bone Defects A Canine Long Bone Study. Presented to the 64 th Annual Meeting of the American Academy of Orthopaedic Surgeons, San Francisco, California, February 13-17, 1997. 93. Curran, R.W., Lemperle, S.M., Calhoun, C.J. Massie, J.B., Holmes, R.E.: The Effect of Bone Marrow and Particulated Autograft on Bone Formation in Subcutaneous Cages Filled With Coralline Hydroxyapatite A Canine Study. Presented at the 23 rd Annual Meeting of the Society for Biomaterials, New Orleans, April 30-May 4, 1997. Curriculum Vitae for Ralph E. Holmes, M.D. - 41

94. Hilfiker, M.L., Hart, M., Holmes, R., Cooper, M., Kriett, J., Collins, D., Allshouse, M. Expansion and Division Separation of Conjoined Twins. Presented at the Annual American Pediatric Surgical Association Meeting, May 18-21, 1997. 95. Lemperle, S., Calhoun, C., Curran, W., Holmes, R.: Comparison of Protected Bone Regeneration, Osteoconduction with Coralline hydroxyapatite Implants and Cancellous Bone Autografts in Large Cranial and Mandibular Defects in Dogs. Presented to the Advancements in Tissue Engineering Meeting, Boston, Massachusetts, June 25-28, 1997. 96. Lemperle, S., Calhoun, C., Curran, W., Massie, J., Holmes, R.: Protected Bone Regeneration: A New Concept in Facilitating the Healing of Large Bone Defects A Canine Long Bone Study. Presented to the Advancements in Tissue Engineering Meeting, Boston, Massachusetts, June 25-28, 1997. 97. Holmes, R.E., Lemperle, S.M., Calhoun, C.J.: A Macroporous Protective Sheet for Bone Regeneration and Implant Containment. International Congress on Bone, San Diego, California, December 11-13, 1997. 98. Berger, J.S., Holmes, R.E., Lemperle, S.M.: New Bone Formation with a Macroporous Protective Sheet. Exhibited at the 8th International Congress on Reconstructive Preprosthetic Surgery, San Diego, California, April 15-17, 1999. 99. Cohen, S.R., Holmes, R.E., Berger, J., Joganic, E., Beals, S.: Internal Craniofacial Distraction Promises, Problems and the Development of a Biodegradable System. Presented to the 79 th Annual Meeting of the American Association of Plastic Surgeons, Laguna Niguel, California, May 7-10, 2000. 100. Cohen, S., Holmes, R., Soltero, R.: Craniofacial Distraction with a Biodegradable Device. Presented to the 50 th Annual Meeting of the California Society of Plastic Surgeons, Santa Monica, California, May 25-29, 2000. 101. Cohen, S.R., Holmes, R.E., Berger, J.S., Kawamoto, H.K.: Tacks: A New Technique of Craniofacial Fixation. Presented to the 50 th Annual Meeting of the California Society of Plastic Surgeons, Santa Monica, California, May 25-29, 2000. 102. Soltero, R., Karamanoukian, R., Cohen, S., Holmes, R.: Initial Experience with a New Biodegradable System. Presented to the 50 th Annual Meeting of the California Society of Plastic Surgeons, Santa Monica, California, May 25-29, 2000. Curriculum Vitae for Ralph E. Holmes, M.D. - 42

103. Machado, L.M., Cohen, S.R., Holmes, R.E.: Distraction of the Craniofacial Skeleton. Presented to the Sociedad Brasileira de Cirurgia Craniomaxilofacia, Sao Paulo, Brazil, June 22, 2000. 104. Machado, L.M., Holmes, R.E., Cohen, S.R.: Protected Bone Regeneration and New Techniques of Biodegradable Fixation. Presented to the Sociedad Brasileira de Cirurgia Craniomaxilofacia, Sao Paulo, Brazil, June 22, 2000. 105. Cohen, S.R., Holmes, R.E., Berger, J.S., Amis, P., Fichtner, H.: Internal Biodegradable Fixation Promises, Problems and the Development of a Biodegradable System. Presented to the 1 st World Cleft Congress of the International Cleft Lip and Palate Foundation, Zurich, Switzerland, July 1-5, 2000. 106. Holmes, R.E., Cohen, S.R., Berger, J.S., Shusterman, E.M., Amis, P., Fichtner, H.: Tacks: A New Technique of Craniofacial Fixation. Presented to the 1 st World Cleft Congress of the International Cleft Lip and Palate Foundation, Zurich, Switzerland, July 1-5, 2000. 107. Holmes, R.E., Cohen, S.R.: Biologic Concepts and Contour Techniques using Resorbable Implants. Medtronic Neurologic Technologies, American Association of Pediatric Neurosurgeons, San Diego, California, December 7, 2000. 108. Cohen, S.R., Holmes, R.E.: Pediatric Craniofacial Surgery using Resorbable Devices. Medtronic Neurologic Technologies, American Association of Pediatric Neurosurgeons, San Diego, California, December 7, 2000. 109. Holmes, R.E.: Bioresorbables in Craniofacial Reconstruction: Life Beyond Fixation. Symposium on Bioresorbables in Craniofacial Reconstruction, Presented to the 27 th Annual Meeting of the Society for Biomaterials, Saint Paul, Minnesota, April 24-29, 2001. 110. Cohen, S.R., Holmes, R.E., Meltzer, H.S., James, H.E.: New Techniques of Craniofacial Fixation: Tacks and Mesh. Presented to the 58 th Annual Meeting of the American Cleft Palate-Craniofacial Association, Minneapolis, Minnesota, April 25-28, 2001. 111. Cohen, S.R., Cho, D.C., Nichols, S.L., Simms, C., Holmes, R.E., Fearon, J., Morales, L., Sadove, M., Eppley, B., Havlick, R., Bartlett, Guyuron, B.: ASMS Outcome Study: Preoperative and Postoperative Neurodevelopmental Findings in Single Suture Craniosynostosis. Presented to the 58 th Annual Meeting of the American Cleft Palate-Craniofacial Association, Minneapolis, Minnesota, April 25-28, 2001. Curriculum Vitae for Ralph E. Holmes, M.D. - 43

112. Cohen, S.R., Holmes, R.E., Meltzer, H.S.: Internal Craniofacial Distraction with Biodegradable Devices. Presented to the 58 th Annual Meeting of the American Cleft Palate-Craniofacial Association, Minneapolis, Minnesota, April 25-28, 2001. 113. Holmes, R.E.: New Techniques: Biodegradable Devices in Craniofacial Surgery. Presented to the 11 th Annual Meeting of the West Virginia Society of Plastic Surgeons, White Sulphur Springs, West Virginia, May 3-4, 2001. 114. Holmes, R.E., Cohen, S.R., Meltzer, H.S., Kikkawa, D.O.: Reconstruction of Complex Orbito-Cranial Deformities: The Role of Bioresorbable Mesh, CT Derived Models, In Situ and Side Table Assembly. Presented to the 51 st Annual Meeting of the California Society of Plastic Surgeons, Monterey, California, May 24-28, 2001. 115. Cohen, S.R., Ruff, P.G., Dobke, M.K., Holmes, R.E.: Craniofacial Distraction in the Infant and Neonate. Presented to the 51 st Annual Meeting of the California Society of Plastic Surgeons, Monterey, California, May 24-28, 2001. 116. Cohen, S.R., Holmes, R.E., Meltzer, H.S.: Internal Craniofacial Distraction with Biodegradable Devices. Presented to the 3 rd International Congress of Craniofacial and Maxillofacial Distraction, Paris, France, June 14-16, 2001. 117. Holmes, R.E., Cohen, S.R., Meltzer, H.S., Kikkawa, D.O.: Reconstruction of Complex Orbito-Cranial Deformities: The Role of Bioresorbable Mesh, CT Derived Models, In Situ and Side Table Assembly. Presented to the 9 th International Congress of the International Society of Craniofacial Surgery, Visby, Gotland, Sweden, June 17-20, 2001. 118. Cohen, S.R., Holmes, R.E., Meltzer, H.S.: Internal Craniofacial Distraction with Biodegradable Devices. Presented to the 9 th International Congress of the International Society of Craniofacial Surgery, Visby, Gotland, Sweden, June 17-20, 2001. 119. Holmes, R.E., Cohen, S.R.: Resorbable Polymers: Their Properties and Biologic Behavior. Presented to the Australasian Society of Maxillofacial Surgeons, Sydney, New South Wales, Australia, August 24-26, 2001. 120. Holmes, R.E., Cohen, S.R.: Protected Bone Regeneration: Fact or Fiction? Presented to the Australasian Society of Maxillofacial Surgeons, Sydney, New South Wales, Australia, August 24-26, 2001. Curriculum Vitae for Ralph E. Holmes, M.D. - 44

121. Holmes, R.E., Cohen, S.R.: Clinical Review of Resorbable Fixation in CMF, Neurosurgical and Orthopedic Applications. Presented to the Australasian Society of Maxillofacial Surgeons, Sydney, New South Wales, Australia, August 24-26, 2001. 122. Cohen, S.R., Holmes, R.E.: Neonatal Mandibular Distraction for Obstructive Sleep Apnea. Presented to the Australasian Society of Maxillofacial Surgeons, Sydney, New South Wales, Australia, August 24-26, 2001. 123. Cohen, S.R., Holmes, R.E.: Internal Craniofacial Distraction for Midface and Frontal Advancement. Presented to the Australasian Society of Maxillofacial Surgeons, Sydney, New South Wales, Australia, August 24-26, 2001. 124. Holmes, R.E., Cohen, S.R.: Pediatric Craniofacial Surgery using Mesh and Tacks. Presented to the Australasian Society of Maxillofacial Surgeons, Sydney, New South Wales, Australia, August 24-26, 2001. 125. Cohen, S.R., Holmes, R.E.: Endoscopic Assisted Treatment of Craniosynostosis with Immediate Reconstruction. Presented to the Australasian Society of Maxillofacial Surgeons, Sydney, New South Wales, Australia, August 24-26, 2001. 126. Holmes, R.E., Cohen, S.R.: Porous Ceramics and Tissue Engineering: Where Have We Been and Where Are We Going? Presented to the Australasian Society of Maxillofacial Surgeons, Sydney, New South Wales, Australia, August 24-26, 2001. 127. Holmes, R.E., Cohen, S.R.: Ear Reconstruction for Microtia. Presented to the Australasian Society of Maxillofacial Surgeons, Sydney, New South Wales, Australia, August 24-26, 2001. 128. Holmes, R.E., Cohen, S.R.: Artecoll: An Injectable Filler for Treating Wrinkles. Presented to the Australasian Society of Maxillofacial Surgeons, Sydney, New South Wales, Australia, August 24-26, 2001. 129. Cohen, S.R., Holmes, R.E.: Cleft Lip and Palate: An Overview of Current Treatment. Presented to the Australasian Society of Maxillofacial Surgeons, Sydney, New South Wales, Australia, August 24-26, 2001. 130. Holmes, R.E., Cohen, S.R.: Soft Tissue Contour Correction using PLA Mesh. Presented to the Australasian Society of Maxillofacial Surgeons, Sydney, New South Wales, Australia, August 24-26, 2001. Curriculum Vitae for Ralph E. Holmes, M.D. - 45

131. Cohen, S.R., Holmes, R.E., Meltzer, H.S., James, H.E., Nakaji, P.: Internal Craniofacial Distraction with New Biodegradable Devices. Poster presentation to the 51 st Annual Meeting of the Congress of Neurological Surgeons, San Diego, California, September 29 October 4, 2001. 132. Holmes, R.E., Cohen, S.R., Meltzer, H.S., Kikkawa, D.O., Nakaji, P.: Reconstruction of Orbito-Cranial Deformities using Resorbable Mesh. Poster presentation to the 51 st Annual Meeting of the Congress of Neurological Surgeons, San Diego, California, September 29 October 4, 2001. 133. Nakaji, P., Cohen, S.R., Holmes, R.E., Meltzer, H.: Endoscopic Correction of Sagittal Synostosis with Resorbable Plates. Poster presentation to the 51 st Annual Meeting of the Congress of Neurological Surgeons, San Diego, California, September 29 October 4, 2001. 134. Ho, KCK, Nicklin S, Gianoutsos MP, Holmes, R, Walsh, WR: Characterisation of a Critical-Size Cranial Defect in a Sheep Model Effect of Size and Protection. Presentation to the Royal Australasian College of Surgeons Annual Scientific Congress, May, 2002. 135. Cohen S.R., Holmes R.E.: Midface and Cranial Distraction in Panel on A Decade of Craniofacial Distraction, McCarthy J.G., moderator. American Association of Plastic Surgery. Seattle, WA, April 29, 2002. 136. Cohen, S.R., Holmes R.E., Meltzer H.E.: Immediate Craniofacial Reconstruction with Bioresorbable Fixation Following Endoscopic Assisted Sagittal and Metopic Synostectomy. American Cleft Palate Craniofacial Association. Seattle, WA, May 3, 2002. 137. Cohen, S.R., Holmes R.E., Meltzer H.E., Kikkawa D.: Reconstruction of Complex Orbito-Cranial Deformities: The Role of Bioresorbable Mesh, CT Derived Models, In Situ and Side Table Assembly. American Cleft Palate Craniofacial Association. Seattle, WA, May 3, 2002. 138. Cohen, S.R., Palla K., Holmes R.E.: Clinical Experience with Polylactic Acid Fixation Devices in Cranio-Maxillofacial Surgery: A 35 Month Follow-up in 109 Patients. American Cleft Palate Craniofacial Association. Seattle, WA, May 3, 2002. 139. Cohen, S.R. Holmes R.E.: Artecoll, A Permanent Wrinkle Augmentation Material: Report of the F.D.A. Study. 52 nd Annual Meeting of the California Society of Plastic Surgery. Rancho Mirage, CA, May 25, 2002. Curriculum Vitae for Ralph E. Holmes, M.D. - 46

140. Chung, C., Holmes R.E., Meltzer H.E., Cohen S.R.: Endoscopic Assisted Synostectomy with Immediate Cranial Reconstruction and Fronto-orbital Osteotomy for Single Suture Craniosynostosis. 52 nd Annual Meeting of the California Society of Plastic Surgery. Rancho Mirage, CA, May 25, 2002. 141. Cohen, S.R., Holmes R.E., Jones, M.C., Machado, L.M.: Rare Causes of Neonatal Airway Obstruction in Bilateral Cleft Lip and Palate: Diagnosis and Treatment. 60 th Annual Meeting of the American Cleft Palate Craniofacial Association. Asheville, NC, April 10, 2003. 142. Cohen, S.R., Holmes R.E., Meltzer, H.K.: Endoscopic Treatment of Craniosynostosis: Fronto-orbital and Cranial Osteotomies with Immediate Reconstruction. 60 th Annual Meeting of the American Cleft Palate Craniofacial Association. Asheville, NC, April 10, 2003. 143. Cohen, S.R., Holmes R.E., Palla, K.D.: Polylactic acid fixation devices in Cranio- Maxillofacial Surgery: A 1-48 Month Followup Study of 164 Patients. 60 th Annual Meeting of the American Cleft Palate Craniofacial Association. Asheville, NC, April 12, 2003. 144. McManus, A.J., Cornwall, G.B., Seim, Moser, R.C., Kisselburgh, C., Thomas, K.A., Holmes, R.E.: Characterization of a Faster Resorbing Polymer After Real Time Ageing. 29 th Annual Meeting of the Society for Biomaterials, Reno, NV, April 30 May 3, 2003. 145. Thomas, K.A., Cornwall, G.B., Seim, H.B., Turner, A.S., Holmes, R.E.: Evaluation of Cranial Flap Fixation using Resorbable Implant Devices in an Adult Ovine Model. 29 th Annual Meeting of the Society for Biomaterials, Reno, NV, April 30 May 3, 2003. Curriculum Vitae for Ralph E. Holmes, M.D. - 47

ABSTRACTS AND PROCEEDINGS 1. Salyer, K.E., Johns, D.F., Holmes, R.E., Layton, J.G.: Evolution of the mandibular mesh implant. Transactions of the 1st Annual Meeting of the Society for Biomaterials and the 7th Annual International Biomaterials Symposium, pg. 23, April 26-30, 1975. 2. Holmes, R.E., Salyer, K.E., Johns, D.F., Layton J.G.: Reconstruction of mandibular continuity defects in dogs with replamineform hydroxyapatite and titanium dioxide. Transactions of the 2nd Annual Meeting of the Society for Biomaterials and the 8th Annual International Biomaterials Symposium, pg. 30, April 9-13, 1976. 3. Holmes, R.E., Salyer, K.E., Tarhay, L., White, E.W.: Reconstruction of the canine mandible with replamineform hydroxyapatite. Transactions of the 3rd Annual Meeting of the Society for Biomaterials and the 9th Annual International Biomaterials Symposium, pg. 111, April 15-19, 1977. 4. Salyer, K.E., Holmes, R.E., Johns, D.F.: Replamineform porous hydroxyapatite as a bone substitute in craniofacial osseous reconstruction. Transactions of the Annual General Session of the American Association for Dental Research, pg. 173, June 23-26, 1977. 5. Holmes, R.E.: Reconstruction of the canine mandible with a coral microstructure implant. Transactions of the 17th Annual Plastic Surgery Senior Residents' Conference, pg. 39, April 9-12, 1978. 6. Holmes, R.E., Salyer, K.E., Hanusiak, W.L.: Bone regeneration in onlay replamineform hydroxyapatite implants. Transactions of the 4th Annual Meeting of the Society for Biomaterials and the 10th Annual International Biomaterials Symposium, pg. 180, April 29 - May 2, 1978. 7. Holmes, R.E., Salyer, K.E.: Bone regeneration in a coralline hydroxyapatite implant. Transactions of the 23rd Annual Meeting of the Plastic Surgery Research Council, May 25-27, 1978. 8. Holmes, R.E., Salyer, K.E.: Bone regeneration in a coralline hydroxyapatite implant. Plastic Surgical Forum, Volume I, pg. 7. Proceedings of the 47th Annual Scientific Meeting of the American Society of Plastic and Reconstructive Surgeons, November 5-10, 1978. 9. Bucholz, R.W., Holmes, R.E., Mooney, V.: Regeneration of articular cartilage over coralline hydroxyapatite. Transactions of the 27th Annual Meeting of the Orthopaedic Research Society, pg. 215, February 23-26, 1981. Curriculum Vitae for Ralph E. Holmes, M.D. - 48

10. Holmes, R.E., Mooney, V., Bucholz, R.W.: Regeneration within canine radius defects treated by coralline implants and iliac autografts. Transactions of the 27th Annual Meeting of the Orthopaedic Research Society, pg. 229, February 23-26, 1981. 11. Holmes, R.E.: What does periosteum contribute to bone regeneration? Transactions of the 26th Annual Meeting of the Plastic Surgery Research Council, pg. 57, May 21-23, 1981. 12. Springer, W.T., Lawrence, K.L., Mooney, V., Holmes, R.E.: Fracture healing assessment via structural frequency. Proceedings of the 34th Annual Conference on Engineering in Medicine and Biology, pg. 160, September 19-21, 1981. 13. Holmes, R.E.: Does implant architecture influence the morphology of bone regeneration? Transactions of the 27th Annual Meeting of the Plastic Surgery Research Council, pg. 101, March 14-17, 1982. 14. Holmes, R.E., Tencer, A.F., Carmichael, T.W., Mooney, V.: Mechanical properties of synthetic hydroxyapatite for cancellous bone grafting. Transactions of the 29th Annual Orthopaedic Research Society, Anaheim, California, March 8-10, 1983. 15. Holmes, R.E., Tencer, A.F., Carmichael, T.W., Mooney, V.: Mechanical properties of synthetic hydroxyapatite for cancellous bone grafting. Orthopaedic Transactions, Volume 7, Number 2, pg. 270, 1983. 16. Holmes, R.E., Tencer, A.F., Carmichael, T.W., Mooney, V.: Mechanical properties of synthetic hydroxyapatite for cancellous bone grafting. Proceedings of the 18th Annual Meeting of the Association for the Advancement of Medical Instrumentation, May 22-25, 1983. 17. Holmes, R.E., Mooney, V.: Stereology of bone regeneration in a synthetic HA implant. Proceedings of the 30th Annual Meeting of the Orthopaedic Research Society, February 6-9, 1984. 18. Tencer, A.F., Bucholz, R.W., Holmes, R.E.: Analysis of variable stiffness external fixation. Proceedings of the 30th Annual Meeting of the Orthopaedic Research Society, February 6-9, 1984. 19. Holmes, R.E.: Histomorphometry of bone regeneration in implant and graft treated radius defects. Transactions of the 29th Annual Meeting of the Plastic Surgery Research Council, pp. 116-119, April 2-4, 1984. Curriculum Vitae for Ralph E. Holmes, M.D. - 49

20. Holmes, R.E., Mooney V.: Bone regeneration in canine radius defects treated by coralline implants and iliac grafts. Transactions of the 2nd World Congress on Biomaterials and the 10th Annual Meeting of the Society for Biomaterials, vol. VII, pg. 154, April 27 - May 1, 1984. 21. Schoenaers, J.H., Holmes, R.E., Finn, R.A., Bell, W.H.: Hydroxylapatite vs autogenous bone for canine interpositional mandibular augmentation: Long term histology and histomorphometry. Transactions of the 66th Annual Meeting of the American Association of Oral and Maxillofacial Surgeons, pg. 68, September 14-18, 1984. 22. Schoenaers, J.H., Holmes, R.E., Finn, R.A., Bell, W.H.: Healing in interconnected porous hydroxylapatite blocks: long term histology and histomorphometry. Transactions of the 11th Annual Meeting of the Society for Biomaterials, vol. VIII, pg. 110, San Diego, California, April 25-28, 1985. 23. Holmes, R.E., Hagler, H.K.: Mandible contour augmentation: autograft vs. porous HA implant. Transactions of the 67th Annual Meeting of the American Association of Oral and Maxillofacial Surgeons, pg. 51, Washington DC, October 3-7, 1985. 24. Bucholz, R.W., Holmes, R.E., Mooney, V.: Synthetic hydroxyapatite as a bone graft substitute in traumatic defects of long bones. Transactions of the 53rd Annual Meeting of the American Academy of Orthopaedic Surgeons, pg. 149, New Orleans, Louisiana, February 20-25, 1986. 25. Holmes, R.E.: Cranial reconstruction with porous hydroxyapatite implants and split rib autografts: a histometric study. Transactions of the 31st Annual Meeting of the Plastic Surgery Research Council, pg. 81-83, Norfolk, Virginia, May 18-21, 1986. 26. Holmes, R.E., Hagler, H.K.: Maxillary contour augmentation: porous HA vs. autograft. Transactions of the 9th International Conference on Oral and Maxillofacial Surgery, pg. 23, Vancouver, B.C., May 21-25, 1986. 27. Schoenaers, J.H., Holmes, R.E., Finn, R.A., Bell, W.H.: Healing in interconnected porous hydroxylapatite blocks: a long term histologic and histomorphometric study. Transactions of the 9th International Conference on Oral and Maxillofacial Surgery, pg. 24, Vancouver, B.C., May 21-25, 1986. 28. Holmes, R.E., Hagler, H.K.: Maxillofacial augmentation: porous HA vs autograft. Transactions of the 12th Annual Meeting of the Society for Biomaterials in conjunction with the 18th International Biomaterials Symposium, Vol IX, pg. 55, Minneapolis, Minnesota, May 28 - June 1, 1986. Curriculum Vitae for Ralph E. Holmes, M.D. - 50

29. Shimizu, T., Videman, T., Zerwekh, J.E., Mooney, V., Holmes, R.E., Hagler, H.K.: The effect of pulsed electromagnetic fields on bone ingrowth into implants. Transactions of the 12th Annual Meeting of the Society for Biomaterials in conjunction with the 18th International Biomaterials Symposium, Vol IX, pg. 82, Minneapolis, Minnesota, May 28 - June 1, 1986. 30. Holmes, R.E., Hagler, H.K.: Craniofacial reconstruction and maxillofacial contour augmentation with porous HA and split rib autografts. Transactions of the 68th Annual Meeting of the American Association of Oral and Maxillofacial Surgeons, pp. 38-39, New Orleans, September 24-28, 1986. Also in Review of the 1986 Annual Scientific Session Abstracts. J. Oral Maxillofac. Surg. 44:M7, 1986. 31. El Deeb, M., Templeton, R.B., Holmes, R.E.: Zygomatic and mandibular augmentation with Proplast and porous hydroxylapatite material in monkeys. Transactions of the 68th Annual Meeting of the American Association of Oral and Maxillofacial Surgeons, pg. 40, New Orleans, September 24-28, 1986. Also in Review of the 1986 Annual Scientific Session Abstracts. J. Oral Maxillofac. Surg. 44:M8, 1986. 32. Holmes, R.E., Hagler, H.K.: Craniofacial reconstruction with porous HA implants and bone autografts. Plastic Surgical Forum, Volume IX, pp. 136-138. Proceedings of the 55th Annual Scientific Meeting of the American Society of Plastic and Reconstructive Surgeons, Los Angeles, California, October 26-31, 1986. 33. Shimizu, T., Zerwekh, J.E., Videman, T., Holmes, R.E., Mooney, V.: The effect of pulsing electromagnetic field on bone ingrowth into porous calcium ceramics. Proceedings of the 33rd Annual Meeting of the Orthopaedic Research Society, San Francisco, California, pg. 234, January 19-22, 1987. 34. El Deeb, M.E., Holmes, R.E.: Facial augmentation with Proplast and porous hydroxylapatite material in primates. J. Dental Res. 66:252, 1987. (Special Issue for Abstracts) 35. Holmes, R.E.: Thick section histometry of porous hydroxyapatite implants using backscattered electron imaging. Proceedings of 2nd International Congress on Preprosthetic Surgery, pg. 61, Palm Springs, California, May 14-16, 1987. 36. Holmes, R.E., LaBorde, R.T., Kitabayashi, L.R.: Automated morphometry of tetracycline labeled bone with scanning electron microscope cathodoluminescence. Proceedings of the 5th International Congress on Bone Morphometry, pg. 147, Niigata, Japan, July 24-29, 1988. Also published in Takahashi, H.E. (ed.): Bone Morphometry, Nishimura Co., Ltd., Niigata (Japan), 1990, pp. 268-271. Curriculum Vitae for Ralph E. Holmes, M.D. - 51

37. El Deeb, M., Holmes, R.E.: Facial contour augmentation with dense and porous hydroxylapatite in Rhesus monkeys. Transactions of the 70th Annual Meeting of the American Association of Oral and Maxillofacial Surgeons, pg. 44, Boston, Massachusetts, September 28-October 2, 1988. 38. Gross, H.N., Holmes, R.E.: Surgical retrieval and histologic evaluation of an endosteal implant. Transactions of the 19th International Dental Implantology Meeting of the G.I.S.I., Bologna, Italy, pp. 13-14, May 26-28, 1989. 39. Holmes, R.E., Shors, E.C., Kopchok, G., Kitabayashi, L.R., LaBorde, R.T.: Effect of implant biodegradation rate on bone repair. Proceedings of the 36th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, pg. 427, February 5-8, 1990. 40. Holmes, R.E., Shors, E.C., Kopchok, G., Kitabayashi, L.R., LaBorde, R.T.: Effect of implant biodegradation rate on bone repair. Transactions of the 68th General Session of the International Association for Dental Research, Cincinnati, Ohio, pg. 353, March 7-11, 1990. 41. Holmes, R.E., Rosenstein, D.A.: Histometry of the Interface in Osseointegration. Proceedings of the International Workshop on Osseointegration in Skeletal Reconstruction and Joint Replacement, Aruba, pg. 161-166, April 24-27, 1990. 42. Holmes, R.E., Shors, E.C., Kopchok, G., Kitabayashi, L.R., LaBorde, R.T.: Effect of implant biodegradation rate on bone repair. Transactions of the 16th Annual Meeting of the Society for Biomaterials, Charleston, South Carolina, Vol. XIII, pg. 290, May 20-23, 1990. 43. Sullivan, P.K., Rosenstein, D.A., Craig, D., Holmes, R.E.: Treatment of large orbital floor defects with plate supported bone grafts: a monkey study. Proceedings of the 59th Annual Meeting of the American Society of Plastic and Reconstructive Surgeons, Boston, Massachusetts, pg. 137-139, October 21-26, 1990. 44. Nelson, J.M., Holmes, R.E., Fisher, J.F., Armstrong, D.A.: Management of Mandibular Fractures in a Public institutional practice. Proceedings of the 41st Annual Meeting of the California Society of Plastic Surgeons, San Francisco, California, pg. 24, March 2-6, 1991. 45. Rosenstein, D.A., Sullivan, P.K., Holmes, R.E., Manson, P.E.: Treatment of large orbital floor defects with plate supported bone grafts: a monkey study. Proceedings of the California Society of Plastic Surgeons, San Francisco, California, pg. 24, March 2-6, 1991. Curriculum Vitae for Ralph E. Holmes, M.D. - 52

46. Rosenstein, D.A., Holmes, R.E., Kitabayashi, L.R.: A histometric and biomechanical comparison of cancellous autografts and xenografts in a beagle tibial defect. Proceedings of the 37th Annual Meeting of the Orthopaedic Research Society, Anaheim, California, pg. 285, March 4-7, 1991. 47. Shors, E.C., Kopchok, G., Holmes, R.E., Rosenstein, D.A., Bumbalough, T.: Biodegradation of porous hydroxyapatite/calcium carbonate implants in rabbits. Proceedings of the 37th Annual Meeting of the Orthopaedic Research Society, Anaheim, California, pg. 510, March 4-7, 1991. 48. Shors, E.C., Rosenstein, D., Holmes, R., Kopchok, G.: The use of porous hydroxyapatite with dental implants in rabbit tibiae. Proceedings of the 4th International Congress on Preprosthetic Surgery, Palm Springs, California, pg. 42, April 18-20, 1991. 49. Kraut, R.A., Dootson, J., Holmes, R.: Osseous ingrowth into porous hydroxyapatite. Proceedings of 4th International Congress on Preprosthetic Surgery, Palm Springs, California, pg. 59, April 18-20, 1991. 50. Shors, E.C., Rosenstein, D., Holmes, R., Kopchok, G.: The use of porous hydroxyapatite granules with dental implants. Transactions of the 17th Annual Meeting of the Society for Biomaterials, Scottsdale, Arizona, pg. 67, May 1-5, 1991. 51. Rosenstein, D.A., Holmes, R.E., Campbell, T.D.: Comparison of autograft and xenograft in a tibial defect: a histometric and biomechanical study. Transactions of the 17th Annual Meeting of the Society for Biomaterials, Scottsdale, Arizona, pg. 226, May 1-5, 1991. 52. Shors, E.C., Rosenstein, D., Holmes, R., Kopchok, G., Bumbalough, T.: The material and in vivo properties of a biodegradable bone graft substitute. Transactions of the 17th Annual Meeting of the Society for Biomaterials, Scottsdale, Arizona, pg. 305, May 1-5, 1991. 53. Rosenstein, D.A., Holmes, R.E.: A histometric and biomechanical comparison of cancellous autografts and xenografts in a canine tibial defect. Proceedings of the 36th Annual Meeting of the Plastic Surgery Research Council, Charlottesville, Virginia, pg. 129-133, May 5-8, 1991. 54. Holmes, R.E.: Fundamentals and applications of histometry for assessing bone repair. Proceedings of Bone Symposium '91, Portland, Oregon, pg. 173-181, July 17-20, 1991. Curriculum Vitae for Ralph E. Holmes, M.D. - 53

55. Le, H.M., Holmes, R.E., Rosenstein, D.A., Shors, E.C.: Computerized quantitative analysis of porous substrates. Proceedings of the Eighth International Congress for Stereology, Irvine, California, pg. 56, August 25-29, 1991. 56. Le, H.M., Holmes, R.E., Shors, E.C., Rosenstein, D.A.: Computerized analysis of porous HA implants. Proceedings of the 2nd UCLA Symposium on Implants in the Partially Edentulous Patient, Palm Springs, California, pg. 29, May 7-9, 1992. 57. Damien, C.J., Parsons, J.R., Prewett, A.B., Huismans, F., Shors, E.C., Holmes, R.E.: Effect of demineralized bone matrix on osteoconduction within a porous HA matrix. Proceedings of the 2nd Annual Conference of the European Orthopaedic Research Society, Varese, Italy, September 27-30, 1992. 58. Cooper, M.L., Nelson, J.M., Holmes, R.E.: Optimizing the Surgical Management of Mandibular Fractures. 43 rd Annual Meeting of the California Society of Plastic Surgeons, Inc. Monterey, California February 26 - March 1, 1993. 59. Calhoun, C.J., Lemperle, S.M., Holmes, R.E. Quantitative Analysis of Dental Implant Osseointegration Using Histometric Image Processing. International Dental Implant Symposium, San Diego, California, November 17-18, 1995. 60. Lemperle, S.M., Calhoun, C.J., Curran, R.W., Holmes, R.E. The Osteoconductive Effect of Coralline Hydroxyapatite on Large Cranial and Mandibular Defects in Dogs. Annual Scientific Meeting of the Southern California Chapter of the American College of Surgeons, Santa Barbara, California, January 19-21, 1996. 61. D Lima, D.D., Lemperle, S.M., Holmes, R.E., Colwell, C.W. Bone Response to Implant Surface Morphology. Transactions of the 42 nd annual meeting, Orthopaedic Research Society, Atlanta, Georgia, February 19-22, 1996. 62. Lemperle, S.M., Calhoun, C.J., Curran, R.W., Holmes, R.E. Comparison of Protected Bone Regeneration, Osteoconduction with Coralline Hydroxyapatite Implants and Cancellous Bone Autografts in Large Cranial and Mandibular Defects in Dogs. Proceedings of the 41 st Annual Meeting of the Plastic Surgery Research Council, St. Louis, Missouri, June 1-4, 1996. 63. Lemperle, S.M., Calhoun, C.J., Curran, R.W., Holmes, R.E. Comparison of Protected Bone Regeneration, Osteoconduction with Coralline Hydroxyapatite Implants and Cancellous Bone Autografts in Large Cranial and Mandibular Defects in Dogs. Proceedings of the 82 nd Clinical Congress of the American College of Surgeons, San Francisco, California, October 6-11, 1996. 64. Miller, S.R., Batra, M.K., Holmes, R.E., Cooper, M.L. Conjoined Twins, Tissue Expanders and Videotape. Proceedings of the American College of Surgeons, Southern California Chapter, Dana Point California, January 24-26, 1997. Curriculum Vitae for Ralph E. Holmes, M.D. - 54

65. Lemperle, S., Calhoun, C., Curran, W., Massie, J., Holmes, R.: Protected Bone Regeneration: A New Concept in Facilitating the Healing of Large Bone Defects A Canine Long Bone Study. Proceedings of the 64 th Annual Meeting of the American Academy of Orthopaedic Surgeons, San Francisco, California, February 13-17, 1997. 66. Cooper, M.L., Holmes, R.E. Conjoined Twins, Tissue Expanders and Videotape. 1997 Annual Meeting Program, California Society of Plastic Surgeons, Inc., San Francisco, California, March 13-16, 1997. 67. Hilfiker, M.D., Hart, M., Holmes, R., Cooper, M., Kriett, J., Collins, D., Allhouse, M. Expansion and Division Separation of Conjoined Twins. Proceedings of the American Pediatric Surgical Association Meeting, May 18-21, 1997. 68. Curran, R.W., Lemperle, S.M., Calhoun, C.J., Massie, J.B., Holmes, R.E. The Effect of Marrow and Particulated Autograft on Bone Formation in Subcutaneous Cages Filled with Coralline Hydroxyapatite: A Canine Study. Transactions of the 23 rd Annual Meeting of the Society for Biomaterials, New Orleans, Louisiana, April 30 May 4, 1997. 69. Lemperle, S., Calhoun, C., Curran, W., Holmes, R.: Comparison of Protected Bone Regeneration, Osteoconduction with Coralline hydroxyapatite Implants and Cancellous Bone Autografts in Large Cranial and Mandibular Defects in Dogs. Proceedings of the Advancements in Tissue Engineering Meeting, Boston, Massachusetts, June 25-28, 1997. 70. Lemperle, S., Calhoun, C., Curran, W., Massie, J., Holmes, R.: Protected Bone Regeneration: A New Concept in Facilitating the Healing of Large Bone Defects A Canine Long Bone Study. Proceedings of the Advancements in Tissue Engineering Meeting, Boston, Massachusetts, June 25-28, 1997. 71. Berger, J.S., Holmes, R.E., Lemperle, S.M.: New Bone Formation with a Macroporous Protective Sheet. Proceedings of the 8th International Congress on Reconstructive Preprosthetic Surgery, San Diego, California, April 15-17, 1999. 72. Holmes, R.E.: Porous Ceramics and Bone Regeneration. Proceedings of the Portland Bone Symposium 99, Portland, Oregon, pg. 460-469, August 4-7, 1999. 73. Cohen, S.R., Holmes, R.E., Berger, J.S., Amis, P., Fichtner, H.: Internal Biodegradable Fixation Promises, Problems and the Development of a Biodegradable System. Proceedings of the 1 st World Cleft Congress of the International Cleft Lip and Palate Foundation, Zurich, Switzerland, July 2, 2000, in Journal of Cranio-Maxillofacial Surgery 28:1 (suppl 1), pg. 17, July 2000. Curriculum Vitae for Ralph E. Holmes, M.D. - 55

74. Holmes, R.E., Cohen, S.R., Berger, J.S., Shusterman, E.M., Amis, P., Fichtner, H.: Tacks: A New Technique of Craniofacial Fixation. Proceedings of the 1 st World Cleft Congress of the International Cleft Lip and Palate Foundation, Zurich, Switzerland, July 3, 2000 in Journal of Cranio-Maxillofacial Surgery 28:1 (suppl 1), pg. 18, July 2000. 75. Holmes, R.E., Cohen, S.R., Meltzer, H.S., Kikkawa, D.O.: Reconstruction of Complex Orbito-Cranial Deformities: The Role of Bioresorbable Mesh, CT Derived Models, In Situ and Side Table Assembly. Proceedings of the 9 th International Congress of the International Society of Craniofacial Surgery, Visby, Gotland, Sweden, June 17-20, 2001, C. Lauritzen (ed), Monduzzi Editore, Bologna, Italy. 76. Cohen, S.R., Holmes, R.E., Meltzer, H.S.: Internal Craniofacial Distraction with Biodegradable Devices. Proceedings of the 9 th International Congress of the International Society of Craniofacial Surgery, Visby, Gotland, Sweden, June 17-20, 2001, C. Lauritzen (ed), Monduzzi Editore, Bologna, Italy. Curriculum Vitae for Ralph E. Holmes, M.D. - 56

JOURNAL PUBLICATIONS 1. Kirchner, J.A., Cornog, J.L., Holmes, R.E.: Transglottic cancer: its growth and spread within the larynx. Arch. Otolaryngol. 99:247-251, 1974. 2. Smith, H.W., Holmes, R.E.: Congenital choanal atresia - surgical correction. Trans. Am. Acad. Ophthalmol. Otolaryngol. 80:527-535, 1975. 3. Trubowitz, S.H., Holmes, R.E.: Epidermoid carcinoma of the maxilla. J. Conn. State Dent. Assoc. 50:18-22, 1976. 4. Sasaki, C.T., Holmes, R.E.: Oncocytoma of the epiglottis. Ear Nose and Throat J. 55:14-20, 1976. 5. Salyer, K.E., Johns, D.F., Holmes, R.E., Layton, J.G.: Evolution of the mandibular mesh implant. J. Biomed. Mater. Res. ll:46l-470, 1977. 6. Salyer, K.E., Newsom, H.T., Holmes, R.E., Hahn, G.: Mandibular reconstruction. Am. J. Surg. 134:461-464, 1977. 7. Holmes, R.E., Salyer, K.E.: Bone regeneration in a coralline hydroxyapatite implant. Surg. Forum 29:611-612, 1978. 8. Holmes, R.E.: Bone regeneration within a coralline hydroxyapatite implant. Plast. Reconstr. Surg. 63:626-633, 1979. 9. Schaefer, S.D., Byrd, H.S., Holmes, R.E.: Forehead and scalp reconstruction after wide-field resection of skin carcinoma. Arch. Otolaryngol. 106:680-684, 1980. 10. Holmes, R.E., Mooney, V., Bucholz, R.W., Tencer, A.F.: A coralline hydroxyapatite bone graft substitute: preliminary report. Clin. Ortho. 188:252-262, 1984. 11. Holmes, R.E., Mooney, V.: Bone regeneration in a cancellous hydroxyapatite implant. Surg. Forum 35:519-521, 1984. 12. Sartoris, D.J., Gershuni, D.H., Akeson, W.H., Holmes, R.E., Resnick, D.: Radiographic evaluation of coralline hydroxyapatite bone graft substitutes: a preliminary report. Radiology 159:133-137, 1986. 13. Holmes, R.E., Bucholz, R.W., Mooney, V.: Porous hydroxyapatite as a bone graft substitute in metaphyseal defects: a histometric study. J. Bone Joint Surg. 68A:904-911, 1986. Curriculum Vitae for Ralph E. Holmes, M.D. - 57

14. Sartoris, D.J., Gershuni, D.H., Akeson, W.H., Holmes, R.E., Resnick, D.: Coralline hydroxyapatite bone graft substitutes: preliminary report of radiographic evaluation. Radiology 159:133-137, 1986. 15. Holmes, R.E., Hagler, H.K.: Cranial reconstruction with porous hydroxyapatite implants and split rib autografts. Surg. Forum 37:617-619, 1986. 16. Sartoris, D.J., Holmes, R.E., Bucholz, R.W., Mooney, V., Resnick, D.: Coralline hydroxyapatite bone graft substitutes in a canine metaphyseal defect model: radiographic-histometric correlation. Investig. Radiol. 21:851-857, 1986. 17. Sartoris, D.J., Holmes, R.E., Tencer, A.F., Carmichael, T.W., Mooney, V., Resnick, D.: Coralline hydroxyapatite bone graft substitutes in a canine metaphyseal defect model: radiographic-biomechanical correlation. Skeletal Radiol. 15:635-641, 1986. 18. Sartoris, D.J., Holmes, R.E., Bucholz, R.W., Resnick, D.: Coralline hydroxyapatite bone graft substitutes in a canine diaphyseal defect model: radiographic features of failed and successful union. Skeletal Radiol.15:642-647, 1986. 19. Holmes, R.E., Bucholz, R.W., Mooney, V.: Porous hydroxyapatite as a bone graft substitute in diaphyseal defects: a histometric study. J. Ortho. Res. 5:114-121, 1987. 20. Bucholz, R.W., Carleton, A., Holmes, R.E.: Hydroxyapatite and tricalcium phosphate bone graft substitutes. Orthop. Clin. North Am. 18:323-334, 1987. 21. Holmes, R.E., Hagler, H.K., Coletta, C.A.: Thick section histometry of porous hydroxyapatite implants using backscattered electron imaging. J. Biomed. Mat. Res. 21:731-739, 1987. 22. Holmes, R.E., Hagler, H.K.: Porous hydroxyapatite as a bone graft substitute in mandibular augmentation: a histometric study. J. Oral Maxillofac. Surg. 45:421-429, 1987. 23. Sartoris, D.J., Holmes, R.E., Bucholz, R.W., Mooney, V., Resnick, D.: Coralline hydroxyapatite bone graft substitutes in a canine diaphyseal defect model: radiographic-histometric correlation. Investig. Radiol. 22:590-596, 1987. 24. Smiler, D.G., Holmes, R.E.: Sinus lift procedure using porous hydroxyapatite: a preliminary clinical report. J. Oral Implantology 13:17-32, 1987. Curriculum Vitae for Ralph E. Holmes, M.D. - 58

25. Holmes, R.E., Roser, S.M.: Porous hydroxyapatite as a bone graft substitute in alveolar ridge augmentation: a histometric study. Int. J. Oral Maxillofac. Surg. 16:718-728, 1987. 26. Shimizu, T., Zerwekh, J.E., Videman, T., Gill, K., Mooney, V., Holmes, R.E., Hagler, H.K.: Bone ingrowth into porous calcium phosphate ceramics: influence of pulsing electromagnetic field. J. Orthop. Res. 6:248-258, 1988. 27. Holmes, R.E., Hagler, H.K.: Porous hydroxyapatite as a bone graft substitute in cranial reconstruction: a histometric study. Plast. Reconstr. Surg. 81:662-671, 1988. 28. Holmes, R.E., Hagler, H.K.: Porous hydroxyapatite as a bone graft substitute in maxillary augmentation: a histometric study. J. Cran-Max.-Fac. Surg. 16:199-205, 1988. 29. Holmes, R.E., Wardrop, R.W., Wolford, L.W.: Hydroxylapatite as a bone graft substitute in orthognathic surgery: histologic and histometric findings. J. Oral Maxillofac. Surg. 46:661-671, 1988. 30. Bucholz, R.W., Carlton, A., Holmes, R.: Interporous hydroxyapatite as a bone graft substitute in tibial plateau fractures. Clin. Orthop. 240:53-62, 1989. 31. Kraut, R.A., Kessler, H.P., Holmes, R.E.: Quantification of bone in dental implant sites after composite grafting of the mandible: report of a case. Int. J. Oral Maxillofac. Implants 4(2):153-158, 1989. 32. El Deeb, M.E., Holmes, R.E.: Tissue response to facial contour augmentation with dense and porous hydroxylapatite in Rhesus monkeys. J. Oral Maxillofac. Surg. 47(12):1282-1289, 1989. 33. Martin, R.B., Chapman, M.W., Holmes, R.E., Sartoris, D.J., Shors, E.C., Gordon, J.E., Heitter, D.O., Sharkey, N.A., Zissimos, A.G.: Effects of bone ingrowth on the strength and non-invasive assessment of a coralline hydroxyapatite material. Biomaterials, 10:481-488, 1989. 34. Gross, H.N., Holmes, R.E.: Surgical retrieval and histologic evaluation of an endosteal implant: a case report with clinical, radiographic, and microscopic observations. J. Oral Implantol. 15:104-113, 1989. 35. El Deeb, M.E., Holmes, R.E.: Zygomatic and mandibular augmentation with Proplast and porous hydroxyapatite in Rhesus monkeys. J. Oral Maxillofac. Surg. 47(5):480-488, 1989. Curriculum Vitae for Ralph E. Holmes, M.D. - 59

36. El Deeb, M., Templeton, B., Holmes, R., Edmund, R.: Facial augmentation with Proplast and non-porous hydroxyapatite in rhesus monkeys. Cleft Palate J. 27:230-239, 1990. 37. Miller, T.A., Ishida, K., Kobayashi, M., Wollman, J.S., Turk, A.E., Holmes, R.E.: The induction of bone by an osteogenic protein and the conduction of bone by porous hydroxyapatite: a laboratory study in the rabbit. Plast. Reconstr. Surg. 87:87-95, 1991. 38. Rosenstein, D.A., Holmes, R.E.: A histometric and biomechanical comparison of cancellous autografts and xenografts in a beagle tibial defect. Surg. Forum 42:538-540, 1991. 39. Le, H.M., Holmes, R.E., Rosenstein, D.A., Shors, E.C.: Computerized quantitative analysis of porous substrates. Acta Stereol. 11:267-272, 1992. 40. Sartoris, D.J., Holmes, R.E., Resnick, D.: Coralline hydroxyapatite bone graft substitutes: radiographic evaluation. J. Foot Surg. 31(3):301-313, 1992. 41. Thaller, S.R., Hoyt, J., Tesluk, H., Holmes, R.: Effect of insulin-like growth factor-1 on zygomatic arch bone regeneration: a preliminary histologic and histometric study. Ann. Plast. Surg. 31(5):421-428, 1993. 42. Thaller, S.R., Hoyt, J., Tesluk, H., Holmes, R.E.: The effect of insulin growth factor-1 on calvarial sutures in a Sprague-Dawley rat. J. Craniofac. Surg. 4(1):35-39, 1993. 43. Sullivan, P.K., Rosenstein, D.A., Holmes, R.E., Craig, D., Manson, P.N. Bonegraft reconstruction of the monkey orbital floor with iliac grafts and titanium mesh plates: A histometric study. Plast. Reconstr. Surg 91(5):769-777, 1993. 44. Moy, P.K., Lundgren, S., Holmes, R.E.: Maxillary sinus augmentation: histomorphometric analysis of graft materials for maxillary sinus floor augmentation. J. Oral Maxillofac. Surg. 51(8):857-862, 1993. 45. Damien, C.J., Parsons, J.R., Prewett, A.B., Huismans, F., Shors, E.C., Holmes, R.E.: Effect of demineralized bone matrix on bone growth within a porous HA material: a histologic and histometric study. J. Biomater. Appl. 9(3):275-288, 1995. 46. Pollick, S., Shors, E.C., Holmes, R.E., Kraut, R.A.: Bone formation and implant degradation of coralline porous ceramics placed in bone and ectopic sites. J. Oral Maxillofac. Surg. 53(8):915-922, 1995. Curriculum Vitae for Ralph E. Holmes, M.D. - 60

47. Thaller, S.R., Moore, A., Tesluk, H., Holmes, R.: Cranial bone grafting: biodegradable versus titanium fixation in a rabbit model. J. Craniofac. Surg. 7(1):54-59, 1996. 48. Wheeler, S.L., Holmes, R.E., Calhoun, C.J.: Six year clinical and histometric study of sinus lift grafts. J. Oral Maxillofac. Implants 11(1):26-34, 1996. 49. Lemperle, S.M., Calhoun, C.J., Curran, R.W., Holmes, R.E.: Comparison of protected bone regeneration, osteoconduction with coralline hydroxyapatite implants and cancellous bone autografts in large cranial and mandibular defects in dogs. Surg. Forum 47:723-727, 1996. 50. Preidler, K.W., Lemperle, S.M., Holmes, R.E., Calhoun, C.J., Shors, E.C., Brossmann, J., Sartoris, D.J.: Coralline hydroxyapatite bone graft substitutes: evaluation of density with dual energy x-ray absorptiometry (DXA). Investig. Radiol. 31(11):716-723, 1996. 51. Lemperle, S.M., Calhoun, C.J., Curran, R.W., Holmes, R.E.: Bony healing of large cranial and mandibular defects protected from soft tissue interposition: a comparative study of spontaneous bone regeneration, osteoconduction, and cancellous autografting in dogs. Plast. Reconstr. Surg. 101(3):660-672, 1998. 52. Mooney, V., Massie, J.B., Lind, B.I., Rah, J.H., Negri, S., Holmes, R.E.: Comparison of hydroxyapatite granules to autogenous bone graft in fusion cages in a goat model. J. Surg. Neurol. 49(6):628-633, 1998. 53. D Lima, D.D., Lemperle, S.M., Chen, P.G., Holmes, R.E., Colwell, C.W.: Bone response to implant surface morphology. J. Arthroplasty 13(8):928-934, 1998. 54. Hilfiker, M.L., Hart, M., Holmes, R., Cooper, M., Kriett, J., Collins, D., Allshourse, M.: Expansion and division of conjoined twins. J. Ped. Surg. 33(5):768-770, 1998. 55. Holmes, R.E.: Management of traumatic auricular injuries in children. Ped. Annals 28(6):391-395, 1999. 56. Cohen, S.R., Holmes, R.E., Amis, P., Fichtner, H.: Internal craniofacial distraction with biodegradable devices: early stabilization and protected bone regeneration. J. Craniofac. Surg. 11(4):354-366, 2000. 57. Cohen, S.R., Holmes, R.E.: Internal LeFort III distraction with biodegradable devices. J. Craniofac. Surg. 12(3):264-272, 2001. 58. Cohen S.R., Holmes R.E., Amis P., Fitchner H., Shusterman E.M.: Tacks: A New Technique for Craniofacial Fixation. J. Craniofac. Surg. 6:596-602, 2001. Curriculum Vitae for Ralph E. Holmes, M.D. - 61

59. Lemperle G., Holmes R.E., Cohen S.R., Lemperle S.M.: A Classification of Facial Wrinkles. Plast. Reconstr. Surg. 108: 1735-1750, 2001. 61. Cohen, S.R., Holmes, R.E., Machado, L., Magit A.: Surgical Strategies in the Treatment of Complex Obstructive Sleep Apnea in Children. Mini-Symposium: Sleep Apnea in Children, C.L. Marcus, Guest Editor, Pediatric Respiratory Reviews: 3: 25-36, 2002. 62. Gosain, A.K., Santoro, T.D., Havlik R.J., Cohen, S.R., Holmes, R.E.: Midface Distraction Following LeFort III and Monobloc Osteotomies: Problems and Solutions. Plast. Reconstr. Surg. 109: 1797-1809, 2002. 63. Cohen, S.R., Holmes, R.E., Meltzer H.S., Nakaji P.: Immediate Cranial Vault Reconstruction with Bioresorbable Plates Following Endoscopically Assisted Sagittal Synostectomy. J. Craniofac. Surg. 13: 578-582, 2002 Curriculum Vitae for Ralph E. Holmes, M.D. - 62

BOOK CHAPTERS 1. Salyer, K.E., Holmes, R.E., Cestero, H.J.: Hard tissue growth and repair. In Whitaker, L.A., Randall, P. (eds.): Symposium for Reconstruction of Jaw Deformity, C.V. Mosby Co., St. Louis, 1978, pp. 33-42. 2. Salyer, K.E., Holmes, R.E.: Mandibular reconstruction including alloplastic materials. In Whitaker, L.A., Randall, P. (eds.): Symposium for Reconstruction of Jaw Deformity, C.V. Mosby Co., St. Louis, 1978, pp. 240-247. 3. Mooney, V., Holmes, R.E.: A new bone graft substitute. In Uhthoff, H.K. (ed.): Current Concepts of External Fixation, Springer-Verlag, Berlin, 1982, pp. 425-431. 4. Tencer, A.F., Holmes, R.E., Johnson, K.D.: Osteocompatibility assessment. In von Recum, A.F. (ed.): Handbook of Biomaterials Evaluation: Scientific, Technical, and Clinical Testing of Implant Materials, Macmillan Publishers, New York, 1986, pp. 321-338. 5. Holmes, R.E.: Alloplastic Implants. In McCarthy, J.G. (ed.): Reconstructive Plastic Surgery, 3rd edition, W.B. Saunders Co., Philadelphia, 1990, pp. 698-731. 6. Tencer, A.F., Shors, E.C., Woodard, P.L., Holmes, R.E.: Mechanical and biological properties of a porous polymer-coated coralline ceramic. In Yamamuro, T., Wilson-Hench, J., Hench, L.L. (eds.): Handbook of Bioactive Ceramics, vol. 2: Calcium Phosphate and Hydroxylapatite Ceramics. CRC Press, Boca Raton, 1991, pp. 209-221. 7. Weinlaender, M., Plenk, H., Adar, F., Holmes, R: TCP-impurities in HA granules and crystallinity changes in plasma flame sprayed HA coatings detected by spectroscopical methods and their consequences. In Ravaglioli, A., Krajewski, A. (eds.): Bioceramics and the Human Body. Elsevier Science Publishers, London, 1992, pp. 317-325. 8. Shors, E.C., Holmes, R.E.: Porous Hydroxyapatite. In Hench, L.L., Wilson, J. (eds.): An Introduction to Bioceramics, World Scientific Publishing Co, Singapore, 1993, pp. 181-198. 9. Cohen, S.R., Holmes, R.E., Machado, L.: Midface Distraction. In Samchukov, M.L., Cope, J.B., Cherkashin, A.M. (eds.): Craniofacial Distraction Osteogenesis, Mosby, St. Louis, 2001, pp. 520-530. 10. Habal, M.B., Holmes, R.E., Cohen, S.R.: The Use of Biomaterials in Craniofacial Trauma. In Thaller, McDonald (eds): Facial Trauma, Marcel Dekker, 2002, (in press). Curriculum Vitae for Ralph E. Holmes, M.D. - 63

COMMENTARY, COMMUNICATIONS, EDITORIALS, AND REVIEWS 1. Ralph E. Holmes, M.D.: Invited Commentary on Facial Bone Grafts: Contemporary Science and Thought, Lawrence Tong and Steven R. Buchman, J Cranio-Maxillofacial Trauma, submitted January 2000. Curriculum Vitae for Ralph E. Holmes, M.D. - 64

INSTRUCTIONAL VIDEOS Maxillary Reconstruction, 1999-11-11, GF.mpg Cranioplasty, 1999-11-11, RF.mpg Unilateral Fronto-Orbital Advancement, 1999-11-17, EG Malar Distraction, 1999-11-19, JCFS.mpg Metopic Fronto-orbital Remodeling, 2000-01-24, JV.mpg Hypertelorbitism Correction, 2000-02-01, KG.mpg Le Fort III Distraction, 2000-04-18, EQ.mpg Curriculum Vitae for Ralph E. Holmes, M.D. - 65

MEDIA CONTRIBUTIONS Newpapers Saving Face: New Hope in Reshaping Features, by Thomas H. Maugh, II, Times Medical Writer. Science File, Los Angeles Times, May 11, 2000, Section B, Page 2. Surgery gives fresh start: Doctors remove large tumor from boy s face, by Kristne Green, Staff Writer, San Diego Union-Tribune, October 6, 2000, Section B, Page 1. Excellent prognosis: Friends cheer boy s hospital release, by Deng-Phuong Nguyen, Staff Writer, San Diego Union-Tribune, October 7, 2000, Section B, Page 2. Magazines Bitter Medicine, by Christopher Hitchens, Vanity Fair, August 1998, Page 48. Medical Specialties, by Eilene Zimmerman, Medical Guide 2000, San Diego Magazine, July 2000, Page 6. Television The High Price of Health, Frontline, PBS Television, May 1997. For the Health of Children, Craniofacial Services, Children s Hospital and Health Center, San Diego, California, Channel 10, January 2000. Natalia Huerta, Craniofacial Surgery, Children's Hospital and Health Center, San Diego, California, Channel 10, March 2000. Through the Eyes of a Child: Natalia Huerta s Story, Children s Hospital and Health Center, San Diego, California, Channel 10, April 2000. Distraction Osteogenesis, Plastic Surgery Educational Foundation Teleplast, Children s Hospital and Health Center, San Diego, California, June 2000. Andre Borovitskiy, Resection of Oral Lymphangioma and Reconstruction of Mandible, Children s Hospital and Health Center, San Diego, California, Multiple Television Stations, September October 2000. Rebecca Xavier, Neonatal Mandibular Distraction, University of California at San Diego Medical Center, San Diego, California, Channel 10, October 2000. Curriculum Vitae for Ralph E. Holmes, M.D. - 66