Think Asia, think Hong Kong - London 13-09-2011 www.hkbio.org.hk BioTech at Science Park Your Safe and Fast Track to China Hong Kong Poised to be the Asia s Biotechnology Hub Albert Cheung Hoi Yu, Ph.D. President Hong Kong Biotechnology Organization (HKBIO) Professor Institute of Systems Biomedicine, Peking University Infectious Disease Center, Peking University Professor and Vice-director Neuroscience Research Institute, Peking University Chairman and CEO Hai Kang Life Corporation Limited Beijing Hai Kang Biotechnology Service Limited
FOSTERING INNOVATION, High-tech industries are increasingly developing into pillar industries of the global economy SCIENCE and TECHNOLOGY For Hong Kong, biotechnology is emerging as the powerhouse engine of science and innovation paving the way for economic growth
Biotechnology in Hong Kong OVERVIEW Recognized by Government as a key growth driver and source of innovation Close to 300 biotech-related companies doing business in the following markets: Healthcare Chinese medicine Medicinal devices Diagnostics Approximately 70 companies listed in Hong Kong Stock Exchange and Growth Enterprise Market Biotechnology and pharmaceutical industries are highly internationalized, occupy little land, product sizes are generally small, hence Hong Kong conditions suitable for industry and growth. Source: Innovation and Technology Commission
SOLID R&D SUPPORT Biotechnology in Hong Kong Among 9 tertiary institutions, 6 heavily engaged in biotechnology-related research Over 250 high-impact biomedical papers published annually Hong Kong s two medical schools are ranked best in world of clinical medicine Increasing Government support for promotion and advancement of Hong Kong s Innovation and Technology HK Government established Innovation and Technology Commission in 1999 to spearhead Hong Kong towards a world-class, knowledge-based economy. ITC has financed more than 150 biotechnology-related projects since its establishment. Source: Innovation and Technology Commission
PERFORMANCE AND RECOGNITION Biotechnology in Hong Kong International recognition in infectious diseases (identification of SARS, Avian Influenza, A/H1N1) Genetically modified organisms Application of molecular testing to food safety Advance research in anti-cancer herbs Achievements in quality control and GMP of Chinese materia medica herbs Molecular approaches to neuroscience research Innovative drug delivery technology Clinical research and biopharmaceuticals accelerating Recognition for protection of IP rights Competitive edge in affiliated technology industries including communication, environmental, nanotechnology and opto-electronics..more
TRENDS AND OPPORTUNITIES MAINLAND CHINA In China, biotechnology industry is concentrated in economically developed regions with prestigious tertiary institutions in Beijing, Guangdong, Shanghai. Jiangsu, Zhejiang and Shangdong Guangdong ranks front in China s manufacturing of Western and Chinese medicine China has made impressive progress in the last two decades building biotechnology industry, however, there remains a lot of challenges and opportunities ahead to succeed in global market given China s accession into WTO. Factors important for China s development of biotechnology includes: Technology, clinical trials Capital market and exit channel with regards to venture capital Regulatory and intellectual property issues Human resource and management Hong Kong is increasingly an attractive place for Mainland to establish biotechnology business
Technology Co-operation with Mainland China China government recognizes Hong Kong as a bridge to the world Mainland and Hong Kong Science and Technology Co-operation Committee - established in 2004 by Ministry of Science and Technology and Hong Kong Special Administrative Region Guangdong / Hong Kong Technology Cooperation Funding Scheme Shenzhen / Hong Kong Innovation Circle 12 State key laboratories located in Hong Kong Focus of China s 11th 5-year plan and the 12 th 5-year plan from 2011-2015
1999 2003 1997
Biochip Players High density glass slidebased microarray for research market Microarray platform for research markets; distributors for AFFYMETRIX in China Electric current-based system chip biochip system ; closed down in 2009 No successful commericalizatoin of the biochip system; business closed down None of them can even try on routine diagnostic market 9
A New Paradigm Going to Revolutionize Clinical Diagnosis
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HKLife EFADchip Technology A key differentiator of EFADchip is the rapid hybridization achieved through proprietary patented technology Our technology avoids undesirable electrochemical reactions and instabilities happened in other electric current driven chip processes Multiplex detection of various targets (diseases) with Scalable, cost effective and established manufacturing processes Worldwide patent portfolio Electric Field Assisted Diagnostic chip EFADchip
HKLife Technology Innovation - EFADchip system EFADchip Wafer EFADchip Automation System EFADchip Analyzer EFADchip Spotter EFADchip Cartridge 13
HKLife Technology Innovation - EFADchip system Molecular Biology Microelectronics Material Science Optics Bioinformatics Precision Engineering 14
Hong Kong Has World-Class Infrastructure Support 1. H HKIB K I BRI B HKPC HKJCICM ASTRI HKSTPC for Biotechnology Development Hong Kong Hong Kong Science and Technology Parks Corporation Hong Kong Applied Science and Technology Research Institute Company Limited Hong Kong Jockey Club Institute of Chinese Medicine Hong Kong Productivity Council Hong Kong Institute of Biotechnology Limited Biotechnology Research Institute and R&D Centres
Beijing R&D Center Hong Kong Laboratory
EFADchip Patent Granted 30 enforceable patents Apparatus and Methods for Detecting DNA in Biological Samples HK 1082771 A Novel DNA Chips System and Its Manufacture China ZL01140901.0 Method of Electrical Hybridization on DNA Chips US 7,390,622, US 7,888,109 Malaysia MY-139466-A, China ZL200480030204.4 Russia 2359038, Mexico 278420 Apparatus and Methods for Detecting DNA in Biological Samples US 7,153,687, US 7,749,705, Australia 2003257367 Europe 1552017 Validated in: Turkey, Belgium, Switzerland, Spain, Greece, Ireland, Monaco, Sweden, Italy, Germany, France, UK, Luxembourg, Netherlands, Denmark, Finland, Portugal Singapore 109848 Improvement on DNA Chips China ZL02282083.3 All owned by HKLife, a Chinese Company
EFADchip Patent Filed 42 pending, 1 proceeding to grant A Novel DNA Chips System and Its Manufacture HK 03107220.4 Method of Electrical Hybridization on DNA Chips HK 07104363.4 US 12/113,392 Malaysia PI20083009 Taiwan 93131325 Thailand 094535 Australia 2004282235 Brazil PI 0.415.342.1 Canada 2542518 China 200480030204.4 Europe 04789841.6 India 1762/DELNP/2006 Japan 2006-534560 South Korea 2006-7007193 Singapore 200602227-1 Singapore 20087795.0 Apparatus and Methods for Detecting DNA in Biological Samples US 12/786,178 Australia 2003257367 Australia 2007224397 Brazil PI 0313409-1 Canada 2495520 China 03819478.3 India 572/DELNP/2005 India 5498/DELNP/2007 Japan 2004-526591 South Korea 2005-7002443 Singapore 200700913-7 (Proceeding to grant) Thailand 094535 Detection of Analytes US 61/195,764 UK 0821126.0 Taiwan 98128515 Thailand 0901004280 Etc. All owned by HKLife, a Chinese Company
HK BIOTECH NEWS WWW.HKBIO.ORG.HK INNOVATION AND TECHNOLOGY - Since 2009 Hong Kong serves as link to China in Biotech Hong Kong is the Chinese city most exposed to the WORLD Good example for rule of law, free flow of information and human rights Strong market economy China looks to Hong Kong for international experience Pearl River Delta/Southern China: 65,000 Hong Kong companies provide employment to over 11 million mainland Chinese Half of China s foreign investment comes from Hong Kong Mainland is Hong Kong s largest trading partner CEPA: first free trade agreement between HK and CHINA Closer Economic Partnership Agreement
Statistics on China Healthcare Institute Healthcare Institute Year Total Total General Hospital Hospital Herbal Hospital Special Hospital Sanat orium Health Clinic Country Clinic Town Clinic Private Clinique Community Health Centre Village Health Room Woman and Children Health Centre Specific Disease Centre CDC Hygiene Control Centre 2005 882206 18703 12982 2620 2682 274 41694 40907 207457 17128 583209 3021 1502 3585 1702 2006 918097 19246 13120 2665 3022 264 40791 39975 212243 22656 609128 3003 1402 3548 2097 2007 912263 19852 13372 2720 3282 237 40679 39876 197083 27069 613855 3051 1365 3585 2553 2008 891480 19712 13119 2688 3437 210 39860 39080 180752 24260 613143 3011 1310 3534 2675 2009 916571 20291 13364 2728 3716 200 39627 38475 182448 27308 632770 3020 1291 3536 2809 2010 936927 20918 13850 2788 4280 204 38836 39175 184848 29308 650749 3025 1274 3513 2913 20 Source: annual statistics of Chinese Medicine, 2010
Global Recognition HKLife pioneering success is well recognized by : Industries local and international Universities and research institutes Government leadership Non-governmental organizations Food and Public Health Authorities International Reference Laboratories IAFP Executive Director visits HKLife laboratory Thailand Ministry of Agriculture and Cooperatives Central Lab Hong Kong Trade Development Council Executive Director Mr. Fred Lam United Nation s FAO Food Safety Officer and Science Director of European Food Safety Authority (EFSA)
Think Asia, think Hong Kong - London 13-09-2011 FOSTERING INNOVATION, SCIENCE and TECHNOLOGY Hong Kong Poised to be the Asia s Biotechnology Hub
For more info: Prof. Albert Cheung-hoi YU, Chairman achy@hkbio.org.hk Tel: (852) 2799 7688 www.hkbio.org.hk