NIDA Big Data Strategic Planning Workgroup

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Transcription:

Big Data Strategic Planning Workgroup June 17, 2015 Co- Chairs: Roger Little, Ph.D. () Massoud Vahabzadeh, Ph.D. ()

Today s Agenda Welcome Review of timeline, work group priorities/activities and June 3 th meeting Comments regarding data curation & analysis and visualization issues and opportunities homework documents Today s Topic Addictome Other Action Items 5 Minute Public Comment Period Wrap- up and Adjourn

Big Data Strategic Planning Work Group Charge and Timeline Charge Develop recommendations on best approaches for to utilize Big Data to advance strategic priorities, including data sharing/ access, analysis, visualization, reproducibility, negative data resource Deliverable = 3-5 page summary of recommendations on leveraging Big Data in the next 5 years Completion Date = Friday, June 26, 2015 Timeline June 30, 2015 RFI soliciting feedback from field regarding s strategic priorities closed February June 2015 Priority area workgroups formed Priority areas = Big Data, Gene x Environment x Development interactions By August, 2015 Bold Goals Challenge winner selected By Summer 2015, Draft Strategic Plan out for public comment By Fall 2015, Final Strategic Plan

Big Data Strategic Planning Work Group Identified Priorities Priority areas identified by work group Data Sharing Data Capture and File Formatting Data Curation & Analysis, Visualization, Machine Learning Where are we in the document development process? What s next?

Big as in lasting significan ce Dark Data Curation drawer phenomenon File Data- driven 4 th Paradigm Reproducibility Hypothesis Generating Long Tail Data Incentivize RRIDs Culture change Harmonization DOIs The Addictome: Enabling Big Data Science

Why create an addictome data resource? To enable Big Data science Data reproducibility Place for negative data Quality metrics and standards 6

Addictome.org Organism 8

Successful long- tail data sharing IMPACT - 20 years of clinical TBI (43,243 patients with TBI, 62 publications) MIASCI and VISION- SCI retrospective pre- clinical CRCNS Data Share for computational modeling 10 yrs, 40 datasets (5 450 GB), 37 secondary analysis publications! small amounts of adequately characterized, focused data are preferable to large amounts of inadequately defined and controlled data stored in a random repository. Gardner et al. 2003

Establishing the Addictome.org Research Areas: Pre- clinical electrophysiology, relapse stage of addiction Goal: Convene investigators in these areas of research with exp erts in data to establish a data sharing framework elements, and standards. Deliverables: A minimum set of common data elements for addiction electrophysiology Create a process to expand the scope of the Addictome to other data types Process and workflows Metadata and labeling of datasets Format: Data types, cost and benefit of sharing raw vs. processed data Costs and funding of data curation and storage, storage repositories Incentivized and/or required data sharing Providing the data in a findable, searchable system

Addictome Meeting Series Agenda 1. Culture Change, convey rationale for establishing the Addictome 2. Use Cases: Investigator applications for big data science 3. Data Formats, Types and Sizes, Raw vs. processed data, Common Data Elem ents (CDEs) 4. Minimum information for a drug addiction (electrophysiology) experiment Metadata 5. Investigator Recommendations towards data curation and storage 6. Providing the data in a findable, searchable system 7. Workflow of producing and sharing research data 8. Workflow of finding and reusing shared research data 9. Ongoing communications, extensibility 10. Plan for expansion into additional DBNBR and research domains

Thank you to Big Data WG Members NAME WORKGROUP CHAIRS Roger Little, PhD Massoud Vahabzadeh, PhD AFFILIATION EXTRAMURAL WORKGROUP MEMBERS Christopher Chute, MD, DrPH Michael Neale, PhD Eric Nestler, MD, PhD Michael Milham, MD, PhD Arthur Toga, PhD Maryanne Martone, PhD Johns Hopkins University Virginia Commonwealth University The Mount Sinai Hospital Child Mind Institute University of Southern California University of California at San Diego NIH STAFF Philip Bourne, PhD Maureen Boyle, PhD Ericka Boone, PhD Udi Ghitza, PhD Steve Gust, PhD Vani Pariyadath, PhD Tom Radman, PhD Joni Rutter, PhD Tisha Wiley, PhD NIH Associate Director for Data Science