CANCER COMMITTEE MEMBERS NORTHWESTERN LAKE FOREST HOSPITAL\ 2010



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CANCER COMMITTEE MEMBERS NORTHWESTERN LAKE FOREST HOSPITAL\ 2010 Michael Cochran, MD Susan Balling R.N. Karline Peal RT Stephen Ganshirt M.D. Nancy Bulzoni Emily Rosecrans Joseph Imperato M.D Linda Dickson MT Sarah Russ Edward Kaplan M.D. Robin Flory PT Cathy Spagnoli RN Marlon Kleinman M.D. Leah Haverhals PT Carroll Stovold LSCW Victoria Kut M.D. Damon Havill Lourdes Swanson Michelle Lee M.D.... Mallory Johnson, RHIA Mary Tebbe RN Leonard Lu M.D. Barb Lichty Jennifer Tepper APN Thomas Mientus M.D. Cindra Macciomei Edye Wagner R.D. Lisa Miller M.D. Linda McBride, CTR Kim Welton Ira Piel M.D. Marianne Mocogni R.N. Kim Wiersma RN Marc Posner M.D. Kim Nagy R.N. Claudia Wiser PT Sonya Sharpless M.D. Marsha Oberrieder Dean Tsarwhas M. D. Alisa Ostebo CANCER COMMITTEE ANNUAL REPORT The 2010 Cancer Committee had a very productive year. The annual goals were set as follows: Quality: Pursue NAPBC Accreditation for Breast Center. Establish a weekly prospective multidisciplinary breast conference. Programmatic: Provide garment fitting services onsite to NLFH Breast Cancer patients. Community Outreach: Improve communication to the general community about Cancer related educational programs offered at NLFH locations. Clinical: Expansion of Radiation and Medical Oncology Services at NLFH Grayslake Facility. We also established that the study topic would be breast and that Dr. Ganshirt would tackle that project. We successfully opened both the Radiation Oncology center at Grayslake, as well as the Outpatient Infusion center, and both were treating patients before the end of the year, improving the quality of care in that region of the state. Karline Peal was named Director

of Oncology Services, and has worked tirelessly to integrate the various programs. See was given the task to oversee the Cancer Center at Grayslake, Radiation Oncology, Outpatient Oncology and the Tumor at the hospital. We have received our results from the Commission on Cancer Survey. We received one contingency on Clinical Staging by Managing Physician Standard 4.3. It should be noted that 50% of programs surveyed have received this contingency. On a positive note we did receive five commendations on the program. We will work to comply with Standard 4.3 and submit supporting documentation to CoC in a timely manner. Since I stepped down as Chair of the Cancer Committee, this will be my last report. I welcome Dr. Lisa Miller as the new Chair. By every measure that we were able to obtain we have been operating extremely successfully with our Cancer Care Program across the board and we look forward to increased improvement of the quality of care of our patients in the forthcoming year. Marc Posner, MD Cancer Committee Chairman 2010 CANCER INCIDENCE New Cancer Cases - Top 5 Sites Total Breast Lung Skin Corpus Bladder Cases Uteri No. % No. % No. % No. % No. % No. % NLFH 546 100 260 47.62 64 11.72 64 11.72 41 7.51 27 4.95 Illinois 63,890 100 8,770 13.73 9,190 14.38 2,060 3.22 1,960 3.07 3,050 4.77 National 1,529,560 100 209,060 13.67 222,520 14.55 68,130 4.45 43,470 2.84 70,530 4.61 County at Diagnosis Count (N) Percentage(%) IL- Lake 649 90.52% IL- Cook 37 5.16% WI 13 1.81% IL-McHenry 7 0.98% FL 3 0.42% IL-Du Page 3 0.42% IL-Boone 2 0.28% IL- Kane 1 0.14% NM 1 0.14% VA 1 0.14% Total 717 100%

2010 SITE DISTRIBUTION BY SEX AND BY CLASS OF CASE ANALYTIC NON- ANALYTIC MALE FEMALE Tongue 5 0 3 2 Salivary Gland 2 1 2 1 Gum and Other Mouth 2 0 1 1 Total Oral Cavity & Pharynx 9 1 6 4 Esophagus 3 1 4 0 Stomach 11 1 5 7 Small Intestine 2 0 1 1 Cecum 3 0 0 3 Ascending Colon 5 0 2 3 Transverse Colon 1 0 1 0 Descending Colon 1 0 0 1 Sigmoid Colon 5 0 4 1 Large Intestine, Nos 2 1 0 3 Total Colon 17 1 7 11 Rectosigmoid Junction 1 0 1 0 Rectum 9 1 4 6 Total Rectum/Rectosigmoid 10 1 5 6 Anus, Anal Canal, Anorectal 2 0 0 2 Liver & Intrahepatic Bile Duct 3 1 2 2 Pancreas 10 3 7 6 Retroperitoneum 1 0 0 1 Total Digestive System 59 8 31 36 Larynx 5 0 4 1 Lung & Bronchus 64 11 38 37 Total Respiratory System 69 11 42 38 Soft Tssue including Heart 2 0 1 1 Total Soft Tissue 2 0 1 1 Melanoma - Skin 62 3 35 30 Total Skin Excluding B &S 54 5 33 26 Breast 260 10 0 270 Total Breast 260 10 0 270 Cervix Uteri 4 0 0 4 Corpus Uteri 41 0 0 41 Ovary 8 0 0 8 Vulva 7 0 0 7 Total Female Genital 60 0 0 60

System Prostate 24 5 29 0 Testis 5 0 5 0 Penis 2 0 2 0 Other Male Genital Organs 1 0 1 0 Total Male Genital System 32 5 37 0 Urinary Bladder 27 2 19 10 Kidney & Renal Pelvis 5 2 5 2 Ureter 2 0 1 1 Total Urinary System 34 4 25 13 Brain 2 1 1 2 Cranial Nerves & Other Nervous 14 0 5 9 Total Brain & Other Nervous 16 1 6 11 Thyroid 15 1 4 12 Total Endocrine 15 1 4 12 Hodgkin Lymphoma 2 0 1 1 Non-Hodgkin Lymphoma 21 6 15 12 NHL-Nodal 18 3 13 8 NHL-Extra Nodal 3 3 2 4 Total Lymphoma 23 6 16 13 Myeloma 4 3 6 1 need tp dp leukemia Lymphocytic Leukemia 1 2 0 3 Other LL 0 1 0 1 Chronic LL 1 1 0 2 Myeloid & Monocytic Leukemia 2 1 1 2 Total Leukemia 3 3 1 5 Mesothelioma 1 0 1 0 Miscellaneous 10 1 5 6 GRAND TOTAL 662 55 219 498 717

NORTHWESTERN LAKE FOREST HOSPITAL BREAST CANCER STUDY This is a retrospective review comparing data from Lake Forest Hospital to 186 hospitals in Illinois for the years 2003-2008. This data does not include review of individual charts. While this data allows us to gauge our hospital relative to similar hospitals in Illinois, it does not provide details for the differences. Incidence of breast cancer 2000-2008 The percentage of breast cancers diagnosed over the past 9 years, as a percentage of total breast cancer diagnosed was highest in 2006 at 14.02% and lowest in 2002 at 9.32% at Northwestern Lake Forest Hospital. The range for the remainder of the state was highest in 2001 at 11.95% and lowest in 2004 at 10.43%. Age group of breast cancer diagnosed 2000-2008 There were 9 categories for patients at the age of diagnosis. There were no patient's under age 20 at Northwestern Lake Forest Hospital versus 3 in Illinois; age 20-29 0.37% versus 0.43%; age 30-39 4.85% versus 4.19%; age 40-49 23.86% versus 17.87%; age 50-59 28.64% versus 24.24%; age 60-69 20.43% versus 22.07%; age 70-79 15.51% versus 18.94%; age 80-89 5.44% versus 10.65%, 90, and over 0.89% versus 1.6% Race/ethnicity of breast cancer diagnosed 2000-2008 The percentage of patients that are White at diagnosis is 88.22% at Northwestern Lake Forest Hospital compared to 81.07% in Illinois; 3.58% were Black versus 11.63% in Illinois; 1.86% was Hispanic versus 3.52% in Illinois. Histology of breast cancer diagnosed 2000-2008 Infiltrating duct carcinoma was 53.91% at Northwestern Lake Forest Hospital versus 64.07% for the remainder of Illinois; lobular carcinoma accounted for 11.56% versus 9.74%; infiltrating duct and lobular carcinoma comprised 12.9% versus 6.11%; infiltrating duct mixed with other types of carcinoma was 7.01% versus 4.19%; other specified types was the remaining 14.62% versus 15.89% First course of treatment of breast cancer diagnosed 2000-2008 There were 10 different treatment protocols following diagnosis including surgery only 18.57% at Northwestern Lake force hospital versus 21.69% in Illinois; surgery and radiation 14.69% versus 12.04%; surgery and chemotherapy 4.7% versus 8.44%; surgery, radiation and chemotherapy 8.5% versus 9.96%; surgery, radiation and hormone therapy 24.38% versus 18.07%; surgery and hormone therapy 5.44% versus 9.33%; surgery, radiation, chemotherapy and hormone therapy 13.72% verses 7.97%; surgery, chemotherapy and hormone therapy 4.85% versus 3.70%; other specified therapy 4.25% versus 6.48%, and no first course of treatment 0.89% versus 2.27%

First course surgery of breast cancer diagnosed 2000-2008 There were 11 different treatment options involving surgery after the diagnosis of breast cancer. These included no surgery of the primary site 1.72% for Northwestern Lake Forest Hospital versus 5.95% in Illinois; local tumor destruction 0% versus 0.02%; partial mastectomy 70.62% versus 58.92%; subcutaneous mastectomy 0.07% versus 0.08%; total mastectomy 15.73% versus 15.57%; modified radical mastectomy 11.41% versus 18.36%; radical mastectomy 0% versus 0.46%; extended radical mastectomy 0% versus 0.02%; mastectomy 0.15% versus 0.25%; surgery NOS 0% versus 0.2%; unknown if surgery performed 0.3% versus 0.16% Stage of breast cancer diagnosed 2000-2008 Stage 0 31.47% at Northwestern Lake Forest Hospital versus 20.49% in Illinois; Stage I 35.5% versus 37.71%; Stage II 22.15% versus 26.17%; Stage III 6.56% versus 8.06%; Stage IV 1.64% versus 4.05%; NA 0.07% versus 0.1%; UNK 2.61% versus 3.41% Additionally, there is data supplied looking at five-year survival from 2003 for Stage 0 through Stage IV disease comparing Northwestern Lake Forest Hospital to 73 Illinois hospitals. Analysis and conclusions The most impressive indicators from reviewing the above data reveal excellent five-year survival statistics for Stage 0 through Stage III patients treated at Northwestern Lake Forest Hospital versus Illinois in general. The number of patients in the Stage IV group was too small for comparison. Unfortunately this does not break out the treatment the patient received in either group to help differentiate the reasons for the difference in survival. The first part of this study indicates a consistent pattern between Northwestern Lake Forest Hospital and the state of Illinois for most statistics. There were large differences especially with lumpectomy versus mastectomy, with lumpectomy much more common at Northwestern Lake Forest Hospital. The stage of cancers diagnosed also tended to be of a lower stage at Northwestern Lake Forest Hospital, and the age of the patient at diagnosis was also younger overall at Northwestern Lake Forest Hospital. Stephen Ganshirt M.D.

Stage 0 revealed five-year survival of 95.8% (50) at NLFH versus 95.5% (1160) in Illinois STAGE 0 SURVIVAL BREAST CANCER DX 2003 At Dx 100% 100% 1 yr 99.5% 100% 2 yr 98.5% 98% 3 yr 97.6% 98% 4 yr 96.8% 98% 5 yr 95.5% 95.8% Suvival Rate % 101% 100% 99% 98% 97% 96% 95% 94% 93% vs. Survival Rate for Breast Cancer at Stage 0 At Dx 1 yr 2 yr 3 yr 4 yr 5 yr Year Data from National Cancer Data Base and Northwestern Lake Forest Hospital NCDB NLFH Number of cases 1160 50

Stage I revealed five-year survival of 96.1% (54) versus 92.6% (2258) STAGE 1 SURVIVAL BREAST CANCER DX 2003 At Dx 100% 100% 1 yr 99.0% 98.1% 2 yr 97.9% 98.1% 3 yr 96.0% 98.1% 4 yr 94.3% 98.1% 5 yr 92.6% 96.1% Suvival Rate % vs. Survival Rate for Breast Cancer at Stage 1 102% 100% 98% 96% 94% 92% 90% 88% At Dx 1 yr 2 yr 3 yr 4 yr 5 yr Year Data from National Cancer Data Base and Northwestern Lake Forest Hospital NCDB NLFH Number of cases 2258 54

Stage II revealed five-year survival of 91.8% (27) versus 86.4% (1661) STAGE 2 SURVIVAL BREAST CANCER DX 2003 At Dx 100% 100% 1 yr 98.2% 100% 2 yr 94.9% 100% 3 yr 92.3% 100% 4 yr 89.3% 100% 5 yr 86.4% 91.8% Suvival Rate % 105% 100% 95% 90% 85% 80% 75% vs. Survival Rate for Breast Cancer at Stage 2 At Dx 1 yr 2 yr 3 yr 4 yr 5 yr Year Data from National Cancer Data Base and Northwestern Lake Forest Hospital NCDB NLFH Number of cases 1661 27

STAGE 3 SURVIVAL BREAST CANCER DX 2003 At Dx 100% 100% 1 yr 93.7% 100% 2 yr 83.8% 98.0% 3 yr 74.4% 98.0% 4 yr 67.5% 98.0% 5 yr 61.9% 95.8% Suvival Rate % 120% 100% 80% 60% 40% 20% 0% vs. Survival Rate for Breast Cancer at Stage 3 At Dx 1 yr 2 yr 3 yr 4 yr 5 yr Year Data from National Cancer Data Base and Northwestern Lake Forest Hospital NCDB NLFH Number of cases 676 18

Stage IV revealed five-year survival of 0% (1) versus 20.5% (252) STAGE 4 SURVIVAL FOR BREAST CANCER DX 2003 At Dx 100% 100% 1 yr 64.8% 0% 2 yr 45.2% 0% 3 yr 31.6% 0% 4 yr 25.8% 0% 5 yr 20.5% 0% Suvival Rate % vs. Survival Rate for Breast Cancer at Stage 4 120% 100% 80% 60% 40% 20% 0% At Dx 1 yr 2 yr 3 yr 4 yr 5 yr Year Data from National Cancer Data Base and Northwestern Lake Forest Hospital NCDB NLFH Number of cases 252 1