CountyCare Appropriate Uses and Safety Edits



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CountyCare Appropriate Uses and Safety Edits The health and safety of our members are top priorities for CountyCare. One of the ways we address patient safety is through point-of-sale (POS) edits at the time a prescription is processed at the pharmacy. These edits are based on U.S. Food and Drug Administration (FDA) recommendations and promote safe and effective medication utilization by our members. The following outlines the types of appropriate uses and safety edits that are in place at CountyCare and the affected drug class or classes. Questions? 312-864-8200 855-444-1661

Quantity Limits: Restrictions on claim quantity per day implemented to prevent doses above the FDA-approved guidelines. Multiple medications within different drug classes have quantity limit requirements. Lower Age Limits: Restrictions on age implemented to prevent children below the FDA-approved age of receiving medications off-label from doing so. Current drug classes with lower age limits include (but are not limited to): Atypical antipsychotics Benzodiazepines Long-acting ADHD medications (stimulants & non-stimulants) Migraine rescue medications (triptans & non-triptans) Sedative hypnotics Short-acting ADHD medications (stimulants only) Upper Age Limits: Restrictions on age implemented to prevent adults from receiving medications commonly indicated for pediatric-use only (without proper documentation of diagnosis). Current drug classes with upper age limits include (but are not limited to): Long-acting ADHD medications (stimulants & non-stimulants) Short-acting ADHD (stimulants only) For specific quantity limits and age limits, please see the CountyCare Preferred Drug List. Duplicate Therapy Edits: Restrictions on claims implemented to prevent members from receiving excessive medication regimens within the same (or similar) drug classes. Current drug classes with duplicate therapy edits include (but are not limited to): ACE inhibitor/angiotensin receptor blockers Alpha-agonists (pediatrics only) Antidepressants (all classes) Atypical antipsychotics Benzodiazepines Diabetic medications (sulfonylurea/ meglitinides) Human immunodeficiency virus medications Long-acting ADHD medications (stimulants & non-stimulants) Opiate analgesics (narcotics) Sedative hypnotics Selective serotonin receptor inhibitors & serotonin norepinephrine receptor inhibitors Short-acting adhd medications (stimulants only) Tricyclic antidepressants Dose Consolidation Edits: Restrictions on claims implemented to prevent members from receiving multiple strengths of the same medication. Current drug classes with dose consolidation edits include: Atypical antipsychotics Long-acting ADHD medications (stimulants & non stimulants) Selective serotonin receptor inhibitors & serotonin norepinephrine receptor inhibitors Short-acting ADHD medications (stimulants only) Step Therapy Edits: Restrictions on claims implemented to steer members toward the preferred medication in the drug class. Current drug classes with step therapy restrictions include (but are not limited to): Acne (oral isotretinoin) Angiotensin receptor blockers Antibiotics (cephalosporins) Aromatase inhibitors Atypical antipsychotics HMG-CoA reductase inhibitors Leukotriene modifiers Nasal steroids Non-sedating antihistamines Ophthalmic antihistamines Sedative hypnotics Teratogenetic Edits: Restrictions on claims implemented to prevent female members from receiving potentially harmful medications prior to confirmation of pregnancy status. (Multiple medications within different drug classes have teratogenetic requirements.) Safety Edits: Restrictions on claims implemented to prevent members from receiving combination drug regimens that are contraindicated or have been deemed toxic and potentially life threatening. Human immunodeficiency virus medications Low dose Seroquel Suboxone/Subutex & narcotics

The following tables detail the specific drugs or processes that are affected by the appropriate uses and safety edits in place at CountyCare. DUPLICATE THERAPY EDIT MEDICATIONS Therapy Category Atypical Antipsychotics Long-acting ADHD Shortacting ADHD Alpha Agonists (for ADHD) SSRIs & SNRIs Tricyclic Antidepressants Antidepressants Preferred Drug List (PDL) and Non-PDL Drug Listing PDL: Abilify, Clozaril (clozapine), Geodon, Risperdal (risperidone), Seroquel, Seroquel-XR, Zyprexa Non-PDL: Abilify Disc, Fanapt, Fazaclo, Invega, Invega Sustenna, Latuda, Risperdal Consta, Saphris, Zyprexa Zydis PDL: Adderall XR (amphetamine-dextroamphetamine ER), Concerta (methylphenidate ER), Dexedrine SR (dextroamphetamine ER), Metadate CD, Ritalin SR Non-PDL: Daytrana, Focalin XR, Ritalin LA, Strattera, Vyvanse PDL: Adderall (amphetamine-dextroamphetamine), Dexedrine (dextroamphetamine), Methylin/Ritalin (methylphenidate) Non-PDL: Focalin (dexmethylphenidate) PDL: Catapres (clonidine), Tenex (guanfacine) Non-PDL: Intuniv, Kapvay PDL: Celexa (citalopram), Effexor (venlafaxine), Effexor XR (venlafaxine ER), Luvox (fluvoxamine), Paxil (paroxetine), Paxil CR (paroxetine ER), Prozac (fluoxetine), Zoloft (sertraline) Non-PDL: Cymbalta, Lexapro, Luvox CR, Pexeva, Pristiq, Viibryd PDL: Anafranil (clomipramine), Elavil (amitriptyline), Norpramin (desipramine), Pamelor (nortiptyline), Sinequan (doxepin), Tofranil (imipramine) Non-PDL: Surmontil (trimipramine), Vivactil (protriptyline) PDL: Anafranil (clomipramine), Celexa (citalopram), Desyrel (trazodone), Effexor (venlafaxine), Effexor XR (venlafaxine ER), Elavil (amitriptyline), Ludiomil (maprotiline), Luvox (fluvoxamine), Nardil (phenelzine), Norpramin (desipramine), Pamelor (nortiptyline), Parnate (tranylcypromine), Paxil (paroxetine), Paxil CR (paroxetine ER), Prozac (fluoxetine), Remeron (mirtazapine), Serzone (nefazodone), Sinequan (doxepin), Tofranil (imipramine), Wellbutrin (bupropion), Wellbutrin SR (bupropion SR), Wellbutrin XL (bupropion XL), Zoloft (sertraline) Non-PDL: Aplenzin, Cymbalta, Lexapro, Luvox CR, Marplan, Oleptro, Pexeva, Pristiq, Surmontil (trimipramine), Viibryd, Vivactil (protriptyline) Limitations polytherapy (two drug drug Applies only to age < 18 polytherapy (two drug

Therapy Category Benzodiazepines Sedative Hypnotics Opiate Analgesics HIV ACEI/ARB Diabetic (Sulfonylureas/ Meglitinides) DUPLICATE THERAPY EDIT MEDICATIONS Preferred Drug List (PDL) and Non-PDL Drug Listing PDL: Ativan (lorazepam), Dalmane (flurazepam), Halcion (triazolam), Klonopin (clonazepam), Librium (chlordiazepoxide), Restoril (temazepam), Serax (oxazepam), Tranxene (clorazepate), Valium (diazepam), Xanax (alprazolam) Non-PDL: Prosom (estazolam) PDL: Ambien (zolpidem), Chloral Hydrate, Dalmane (flurazepam), Halcion (triazolam), Restoril (temazepam), Sonata (zaleplon) Non-PDL: Ambien CR (zolpidem ER), Doral, Prosom (estazolam), Lunesta, Rozerem, Seconal PDL: Dolophine (methadone), MS Contin (morphine sulfate 12hr ER), shortacting medication which contains any of the following active ingredients: oxycodone, hydrocodone, hydromorphone, propoxyphene, codeine, morphine, meperidine, butalbital Non-PDL: Long-acting or short-acting medication which contains any of the following active ingredients: fentanyl, buprenorphine, oxymorphone, pentazocine (not mentioned on the PDL list) See safety edit below (all HIV medications are PDL) PDL: Accupril (quinapril), Altace (ramipril), Capoten (captopril), Cozaar (losartan), Diovan, Lotensin (benazepril), Mavik (trandolapril), Monopril (fosinopril), Vasotec (enalapril), Zestril (lisinopril), plus any of the following drugs in combination with HCTZ Non-PDL: Aceon (perindopril), Atacand, Avapro, Benicar, Edarbi, Micardis, Teveten, Univasc (moexipril), plus any of the following drugs in combination with HCTZ or other cardiovascular medications PDL: Amaryl (glimepiride), Diabeta (glyburide), Glucotrol (glipizide), Glucotrol XL (glipizide SR), Glucovance (glyburide-metformin), Glynase (glyburide micronized), Metaglip (glipizide-metformin) Non-PDL: Avandaryl, Diabinese (chlorpropamide), Duetact, Dymelor (acetohexamide), Orinase (tolbutamide), Prandimet, Prandin, Starlix (nateglinide), Tolinase (tolazamide) Limitations polytherapy (two drug two claims per 30 days one medication per group (per

Therapy Category Atypical Antipsychotics Long-acting ADHD Shortacting ADHD SSRIs & SNRIs PDL: Abilify, Zyprexa DUPLICATE THERAPY EDIT MEDICATIONS Preferred Drug List (PDL) and Non-PDL Drug Listing Non-PDL: Abilify Disc, Fanapt, Invega, Saphris, Zyprexa Zydis PDL: Adderall XR (amphetamine-dextroamphetamine ER), Concerta (methylphenidate ER), Dexedrine SR (dextroamphetamine ER), Metadate CD, Ritalin SR Non-PDL: Daytrana, Focalin XR, Ritalin LA, Strattera, Vyvanse PDL: Adderall (amphetamine-dextroamphetamine), Dexedrine (dextroamphetamine), Methylin/Ritalin (methylphenidate) Non-PDL: Focalin (dexmethylphenidate) PDL: Celexa (citalopram), Luvox (fluvoxamine), Paxil (paroxetine), Paxil CR (paroxetine ER), Prozac (fluoxetine), Zoloft (sertraline) Non-PDL: Lexapro, Luvox CR, Pexeva, Pristiq, Viibryd Limitations one strength per drug (per one strength per drug (per one strength per drug (per one strength per drug (per TERATOGENETIC EDIT PROGRAMMING DETAIL Step Question Answer/Action 1. Is member female? Yes: Go to Step 2 No: Process claim 2. Is member between 11 50 years of age? Yes: Go to Step 3 No: Process claim 3. Does the member have an active claim for contraception or hormone replacement therapy? Yes: Process claim No: Go to Step 4 4. Is the member pregnant? (Pharmacist to ask member at POS) Yes: Go to Step 5 No: Process claim 5. Is the drug labeled as pregnancy category X? Yes: Deny claim No: Go to Step 6 6. Is the drug labeled as pregnancy category D (risk outweighs benefit)? Yes: Deny claim No: Go to Step 7 7. Is the drug labeled as pregnancy category D (benefits may outweigh risk)? Yes: Go to Step 8 No: Process claim 8. Call prescriber. Does benefit outweigh risks? Yes: Process claim No: Deny claim

STEP THERAPY EDIT MEDICATIONS Therapeutic Category First Line Preferred Drug Step Therapy Drug (second line preferred) Atypical Antipsychotics Rispedal (risperidone) Abilify, Clozaril (clozapine), Geodon, Seroquel, Seroquel-XR, Zyprexa Sedative Hypnotics Ambien (zolpidem) Sonata Angiotensin Receptor Blockers Cozaar (losartan) Hyzaar (losartan-hctz) Diovan Diovan-HCT Non-sedating Antihistamines Claritin (loratadine), Zyrtec (cetirizine) Allegra (fexofenadine) HMG-CoA Reductase Inhibitors Mevacor (lovastatin), Pravachol (pravastatin), Zocor (simvastatin) Lipitor (atorvastatin) Ophthalmic Antihistamines Opticrom (Cromolyn), Zaditor (Ketotifen) Alomide, Alocril, Optivar Nasal Steroids Flonase (fluticasone) Nasonex, Nasacort AQ Antibiotics (Cephalosporin) Leukotriene Modifiers (asthma) Leukotriene Modifiers (allergy) Amoxil (amoxicillin), Augmentin (amoxicillin-clavulanate), Biaxin (clarithromycin), Ceclor (cefaclor), Cefzil (cefprozil), Levaquin (levofloxacin), Zithromax (azithromycin) Advair, Flovent, Proair (albuterol), Pulmicort (budesonide), QVAR Claritin (loratadine), Flonase (fluticasone), Zyrtec (cetirizine) Omnicef (cefdinir) Singulair Singulair Aromatase Inhibitors Arimidex (anastrozole) Aromasin, Femara Acne (oral) Oral Antibiotics (minocycline, etc) AND topical tretinoin (Retin-A etc) Accutane, Amnesteem, Claravis, Sotret SAFETY EDIT PROGRAMMING DETAIL Edit HIV Medication Edit Low-Dose Seroquel Suboxone/Subutex & Narcotics Rationale Regimens deemed toxic or potentially life threatening are prevented from adjudicating concurrently (see below for restricted regimens) Low-dose Seroquel regimens (<150mg/day) are allowed for titration purpose only, as per FDA-approved indications (adult restrictions only) Suboxone/Subutex regimens are prevented from adjudicating in members with active narcotic claims (Subxoone/Subutex are only approved for opiate withdrawal indications)

TERATOGENETIC EDIT MEDICATIONS Pregnancy Category Pregnancy Category X Pregnancy Category D (risk outweighs benefit) Pregnancy Category D (benefits may outweigh risk) Therapeutic Category 5-Alpha Reductase Inhibitors, Anabolic Steroids, Androgens, Anorexiants, Antineoplastics, Coumadin Anticoagulants, Endothelin Receptor Antagonists, Hepatitis Agents, HMG- CoA Reductase Inhibitors, Non-Barbiturate Hypnotics, Migraine Agents, Non-steroidal Antiinflammatory, Progesterone Receptor Antagonists, Progestins, Prostaglandins, Retinoids, Stimulant Laxatives, etc ACE Inhibitors, Alkylating Agents, Aminoglycosides, Antiandrogents, Antiestrogens, Antineoplastics, Beta Blockers, Gout Agents, Mitiotic Inhibitors, Potassium Sparing Diuretics, Sickle Cell Anemia Agents, Selective Serotonin Reuptake Inhibitors, Smoking Deterrents, Tetracyclines, Thiazide & Thiazide Like Diuretics, Trycyclic Antidepressants, etc Anticonvulsants, Antithyroid Agents, Antiretrovirals, Antispasmodics, Barbiturate Hypnotics, Benzodiazepines, Glucocorticoids, Hydantoins, Imidazole Antifungals, Immunosuppressives, Lithiums, Non-Barbiturate Hypnotics, etc NOTE: These lists are not all inclusive of drugs in pregnancy category X and/or D. Furthermore, not all drugs within the therapeutic categories listed above are categorized as pregnancy X and/or D. HIV SAFETY EDIT MEDICATIONS Regimen 1. Atripla (efavirenz, emtricitabine, tenofovir), Emtriva (emtricitabine), Truvada (emtricitabine, tenofovir) 2. Epzicom (abacavir, lamivudine), Ziagen (abacavir), Trizivir (abacavir, lamivudine, zidovudine) 3. Combivir (lamivudine, zidovudine), Epivir (lamivudine), Trizivir (abacavir, lamivudine, zidovudine) 4. Truvada (emtricitabine, tenofovir), Viread (tenofovir) 5. Complera (emtricitabine, rilpivirine, tenofovir) 6. Reyataz (Atazanavir), Crixivan (Indinavir) 7. Videx (didanosine), Zerit (stavudine) 8. Emtriva (emtricitabine), Epivir (lamivudine) 9. Zerit (stavudine), Retrovir (zidovudine) 10. Videx (didanosine), Viread (tenofovir) 11. Zerit (stavudine), Trizivir (abacavir, lamivudine, zidovudine) 12. Zerit (stavudine), Combivir (lamivudine, zidovudine) 13. Zerit (stavudine), Combivir (lamivudine, zidovudine)

HIV SAFETY EDIT MEDICATIONS Regimen 14. Videx (didanosine), Truvada (emtricitabine, tenofovir) 15. Truvada (emtricitabine, tenofovir), Epivir (lamivudine) 16. Truvada (emtricitabine, tenofovir), Epzicom (abacavir, lamivudine) 17. Truvada (emtricitabine, tenofovir), Trizivir (abacavir, lamivudine, zidovudine) 18. Truvada (emtricitabine, tenofovir), Combivir (lamivudine, zidovudine) 19. Atripla (efavirenz, emtricitabine, tenofovir), Epivir (lamivudine) 20. Atripla (efavirenz, emtricitabine, tenofovir), Epzicom (abacavir, lamivudine) 21. Atripla (efavirenz, emtricitabine, tenofovir), Trizivir (abacavir, lamivudine, zidovudine) 22. Atripla (efavirenz, emtricitabine, tenofovir), Combivir (lamivudine, zidovudine) 23. Epzicom (abacavir, lamivudine), Emtriva (emtricitabine) 24. Emtriva (emtricitabine), Trizivir (abacavir, lamivudine, zidovudine) 25. Combivir (lamivudine, zidovudine), Emtriva (emtricitabine) 26. Rescriptor (Delavirdine), Sustiva (Efavirenz), INTELENCE (Etravirine), Viramune (Nevirapine), Atripla (Efavirenz, Emtricitabine, Tenofovir), Edurant (Rilpivirine) CountyCare covered products are listed in the PDL. For the most current PDL please contact CountyCare at 312-864-8200 / 855-444-1661 (toll-free) / 711 (TDD/TTY) or visit the website at www.illinicare.com.