Program details inside. MyIgSource is open to all Primary Immunodeficiency (PI) patients and caregivers regardless of treatment.

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1 Support for living hands-on Nancy Travel enthusiast living with PI Program details inside. MyIgSource is open to all Primary Immunodeficiency (PI) patients and caregivers regardless of treatment. Please see Indication and Detailed Important Risk Information on pages and and accompanying full Prescribing Information, including Boxed Warning.

2 About the Program Mike Life is full of beginnings, and a primary immunodeficiency (PI) diagnosis is one of them. MyIgSource is here to support you throughout your PI journey. The support Mike receives from talking to his Patient Advocate helps him stay focused on making music. Insurance & Financial Support Understanding health insurance Navigating coverage Copay assistance Reach out for support today. Nurse Advocates Available to answer Baxter Ig products and administration questions MyIgSource.com Educational Resources & Tools Educational books, magazines, s and more about managing your PI journey 2 Julie Patient Advocates Connect with other patients and caregivers living with PI Your guide to all things MyIgSource Even PI veterans like Julie need support once in a while. Julie uses resources like the book You re Not Alone to help her family and friends understand her PI journey. Nancy Thanks to the easily digestible articles in JLM magazine (also known as Just Like Me), Nancy stays informed about PI and still has time to hit the slopes. 3

3 Connect with Patient Advocates You are not alone. MyIgSource can connect you with other patients and caregivers living with primary immunodeficiency (PI). Find emotional support by talking one-on-one with these Patient Advocates who have firsthand experience with managing the daily challenges of PI. Call to talk with a Patient Advocate today. Annaben Annaben has a strong passion for advocacy and a personal connection to the PI community as a mother of a teen with PI. She was an educator for more than 15 years and has written about PI extensively. Annaben has three children. Meet Our Patient Advocates Dayna Patient Advocate and mother of four children with PI, Dayna is the Editor-in-Chief of Just Like Me magazine and co-creator of the Therapeutic Play Kit. Dayna created the My IgG Book for her oldest son, Charlie. Julie For Julie, a PI diagnosis didn t mean giving up an active lifestyle. In fact, shortly after being diagnosed, she participated in her first relay event to raise awareness of PI. Julie is married with a stepson and has worked as an ultrasound technician for more than 10 years. Kristin Patient Advocate Kristin is a mother of four who has experienced the pain of misdiagnosis of one of her children and the comfort that comes from speaking with other caregivers and patients. Karen Karen was diagnosed with PI in As a working mother of three adolescent children and the wife of a police officer, Karen knows a thing or two about managing a chronic illness along with everyday life. Tarsha Patient Advocate Tarsha understands the value of MyIgSource firsthand. Diagnosed with common variable immunodeficiency, she took advantage of the resources and tools the program offers. Tarsha looks forward to helping with the journey for other patients. Reach out for support today. Call or visit MyIgSource.com to enroll in the program. 4 5

4 Find Helpful Information Educational Resources & Tools Insurance & Financial Support Let s face it. Health insurance can be daunting or confusing, to say the least. MyIgSource can help you better understand your health insurance and the processes involved, from coverage to open enrollment to insurance changes and more. We also offer copay assistance cards for select Baxter products to help ease the financial burden of Ig treatment. To learn more about these programs, please see pages 9 and 13. Nurse Advocates Searching for accurate and credible information about PI can be time-consuming and frustrating. That s why MyIgSource offers you the following resources, specifically designed by patients for patients, to help you better understand and manage primary immunodeficiency (PI). Just Like Me JLM (also known as Just Like Me) is a magazine that engages people of all ages and helps them better understand and manage PI. Living With PI Series Receive relevant tips and information to help you on your PI journey. MyIgSource can also connect you with nurses experienced in helping patients manage their PI and immunoglobulin treatment. These Nurse Advocates can answer questions about administration and help you talk to your doctor about your treatment.* *Nurse Advocates cannot provide medical advice. Please contact your physician for any medical questions. Therapeutic Play Kit This kit helps families learn how to cope with the medical environment through therapeutic play. You re Not Alone This book features 22 real patients and caregivers sharing their thoughts on the PI journey. Celina s Story Walk through the PI diagnosis and coping processes with Celina, a young lady with PI. A Look Inside the Immune System This educational flip book provides a simplified insight into the biological structures and processes of the human immune system. Reach out for support today. Call or visit MyIgSource.com to enroll in the program. My IgG Book Kit This kit lets children follow the story of Charlie s infusion. The Adventures of Incredible Antibody This comic offers a fun, easy way to understand how Immune Globulin is made, from plasma collection to the lab and all the way to the patient for treatment. 6 7

5 About HYQVIA HYQVIA Resources Selected Important Risk Information HYQVIA is a new subcutaneous immunoglobulin that can be administered in one infusion site, once a month (every 3-4 weeks) HYQVIA is an immune globulin with a recombinant human hyaluronidase indicated for the treatment of Primary Immunodeficiency (PI) in adults. This includes, but is not limited to, common variable immunodeficiency (CVID), X-linked agammaglobulinemia, congenital agammaglobulinemia, Wiskott-Aldrich syndrome, and severe combined immunodeficiencies. Limitation of Use: Safety and efficacy of chronic use of recombinant human hyaluronidase in HYQVIA have not been established in conditions other than PI. CoPay Assistance Eligible PI patients on HYQVIA with commercial insurance may be able to start saving on their copay, coinsurance or deductible for medication costs with the HYQVIA Copay Card, worth up to $4,000 over 12 months.* Terms and conditions apply. Baxter's co-pay programs are subject to change. HYQVIA Patient Training Tools Get the HYQVIA Starter Kit, including a step-by-step guide and DVD, a sling bag, a hot/cold pack and an antibacterial towel to make the transition to HYQVIA as simple as possible. My Infusion Log Stay on top of your treatment and overall wellness by logging your infusions after every treatment, tracking your daily health, and communicating this information to your healthcare team. HYQVIA can cause serious side effects. Call your healthcare professional or go to your emergency department right away if you get: Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction. Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of swelling in your brain. Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem. Pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s). These could be signs of a blood clot. Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem. Chest pain or trouble breathing, blue lips or extremities. These could be signs of a lung problem. *Non-medication expenses, such as ancillary supplies or administration-related costs, are not eligible. These are not all the possible side effects with HYQVIA. Talk to your healthcare professional about any side effects that bother you or that don t go away. The frequency and number of infusion sites can be adjusted based on the patient s clinical response, taking into consideration volume, total infusion time and tolerability. Please see Indication and Detailed Important Risk Information on pages and accompanying full Prescribing Information, including Boxed Warning. To request these resources, please call MyIgSource at HYQVIA.com

6 What are the possible or reasonably likely side effects of HYQVIA? Indication HYQVIA is an immune globulin with a recombinant human hyaluronidase indicated for the treatment of Primary Immunodeficiency (PI) in adults. This includes, but is not limited to, common variable immunodeficiency (CVID), X-linked agammaglobulinemia, congenital agammaglobulinemia, Wiskott-Aldrich syndrome, and severe combined immunodeficiencies. Limitation of Use: Safety and efficacy of chronic use of recombinant human hyaluronidase in HYQVIA have not been established in conditions other than PI. Detailed Important Risk Information HYQVIA can cause serious side effects. Call your healthcare professional or go to your emergency department right away if you get: Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction. Bad headache with nausea, vomiting, stiff neck, fever, and sensitivity to light. These could be signs of swelling in your brain. Reduced urination, sudden weight gain, or swelling in your legs. These could be signs of a kidney problem. Pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s). These could be signs of a blood clot. Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver or blood problem. Chest pain or trouble breathing, blue lips or extremities. These could be signs of a lung problem. After HYQVIA infusion a temporary, soft swelling may occur around the infusion site, which may last 1 to 3 days, due to the volume of fluid infused. Mild or moderate pain, redness, swelling or itching may occur at the site of infusion and generally go away in a few hours. Local reactions are less likely after the first few infusions. The most common side effects of HYQVIA are headache, fatigue, nausea, fever, and vomiting. Antibodies to the hyaluronidase component of HYQVIA were formed in some patients taking HYQVIA. It is not known if there is any long term effect. In theory, these antibodies could react with your body s own PH20. PH20 is present in the male reproductive tract. So far, these antibodies have not been associated with increased or new side effects. What is HYQVIA? HYQVIA is a liquid medicine containing immune globulin and recombinant human hyaluronidase. HYQVIA contains IgG antibodies, collected from human plasma donated by healthy people. The antibodies help your body to fight off bacterial and viral infections. The hyaluronidase part of HYQVIA helps more of the immune globulin get absorbed into the body to fight infection. Before starting HYQVIA, tell your healthcare professional if you have or had any kidney, liver, or heart problems, a history of blood clots, because HYQVIA can make these problems worse. Also tell your doctor if you have IgA deficiency or a history of severe allergic reactions to immune globulin (IgG) or other blood products, or are pregnant, trying to become pregnant or are breast feeding. How should I take HYQVIA? HYQVIA is infused under the skin (subcutaneously) up to once every 4 weeks. You can get HYQVIA at your healthcare professional s office, clinic, or hospital. You can use HYQVIA at home. You and your healthcare professional will decide if home self-infusion is right for you. Do not use HYQVIA at home until you get instructions and training from your healthcare professional. These are not all the possible side effects with HYQVIA. Talk to your healthcare professional about any side effects that bother you or that don t go away. What is the most important information that I should know about HYQVIA? HYQVIA can cause blood clots. Call your healthcare professional if you have pain, swelling, warmth, redness, or a lump in your legs or arms, other than at the infusion site(s), unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness or weakness on one side of the body. Your healthcare professional may perform blood tests regularly to check your IgG level. With your consent, your healthcare professional may provide blood samples to Baxter Healthcare Corporation to test for antibodies that may form against the hyaluronidase part of HYQVIA. Do not infuse HYQVIA into or around an infected or red swollen area because it can cause infection to spread. Talk to your healthcare professional if you become pregnant. Women who become pregnant during HYQVIA treatment are encouraged to enroll in the HYQVIA Pregnancy Registry by calling Medical Information at Who should not take HYQVIA? Do not take HYQVIA if you are allergic to IgG, hyaluronidase, or other blood products, or have IgA deficiency with antibodies to IgA. To report suspected side effects, contact Baxter Healthcare Corporation at or FDA at FDA-1088 or

7 About GAMMAGARD LIQUID GAMMAGARD LIQUID Resources My Infusion Log & Wellness Calendar Stay on top of your treatment and overall wellness by logging your infusions after every treatment, tracking your daily health, and communicating this information to your healthcare team. Protect Life s Moments With Two Routes of Administration Ig can be infused either directly into a vein (intravenous) or just under the skin into the fatty tissue (subcutaneous). GAMMAGARD LIQUID offers a choice of intravenous (IV) and conventional subcutaneous (SubQ) administration options. 2 GAMMAGARD LIQUID SubQ Administration Resources Administration Location Talk to your healthcare provider about the treatment options that work best for you and your lifestyle. Intravenous (IV) 2,3 Infused directly into the bloodstream through a vein Conventional Subcutaneous (SubQ) 2,3 Infused under the skin in the fatty tissues of the abdomen, thigh, upper arm, or lower back Enroll in GAMMAGARD LIQUID SubQ CoPay today! Save up to $2500 on your deductible/co-payment/co-insurance ce costs over 12 months** To enroll, simply call (855) to speak with a Patient Advocate. Please review Indication and Detailed Important Risk Information in the GAMMAGARD LIQUID SubQ CoPay Card Brochure and accompanying full Prescribing Information, including the Patient Product Information. Also available at SubQ CoPay Card A deductible/co-payment/co-insurance savings offer that provides eligible primary immunodeficiency (PI) patients with savings up to $2500 over 12 months to help cover the medication costs for GAMMAGARD LIQUID administered subcutaneously (SubQ).* Visit GAMMAGARD.com for Terms and Conditions. SubQ Travel Kit Frequency* Number of Sites Every 3-4 weeks One Once a week Dose can be given in multiple sites, not to exceed 8 This compact kit helps organize everything you need to self-infuse while traveling so that you can relax and travel with confidence. SubQ Patient Training Kit Who Administers Where Ig is Administered A doctor, nurse, or other healthcare professional At a hospital or clinic or at home Can be self-infused after training by a qualified healthcare professional At home Get a training DVD, infusion mat, and step-by-step guide with in-depth information to help you get started on subcutaneous (SubQ) administration of GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10%. *Non-medication expenses, such as ancillary supplies or administration-related costs, are not eligible. *Based on clinical response. Please see Indication and Detailed Important Risk Information on pages and accompanying full Prescribing Information, including Boxed Warning. To request these resources, please call MyIgSource at GAMMAGARD.com

8 Indication GAMMAGARD LIQUID is used to treat patients two years of age and older with primary immunodeficiency diseases (PI). There are many forms of PI. GAMMAGARD LIQUID contains antibodies collected from healthy people that replace the missing antibodies in PI patients. Detailed Important Risk Information Stop the infusion immediately and contact your healthcare provider or call emergency services if you have any of the following: Symptoms of thrombosis (blood clots) that may include: pain and/or swelling of an arm or leg with warmth over the affected area, discoloration (redness) or lump in an arm or leg, unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, numbness or weakness on one side of the body. Symptoms of a kidney problem that may include: reduced urination, sudden weight gain or swelling in your legs. Symptoms of a serious allergic reaction that may include: hives, skin rash, itching, swelling in the mouth or throat, trouble breathing, wheezing, fainting or dizziness. Other serious symptoms including: bad headache with nausea, vomiting, stiff neck, drowsiness, fever, sensitivity to light, painful eye movements; brown or red urine, fast heart rate, yellow skin or eyes; trouble breathing, blue lips or extremities; fever over 100 F. Tell your healthcare provider if you have a history of thrombosis (blood clots), thrombotic events, poor kidney function or kidney failure. Do not use GAMMAGARD LIQUID if you have a known history of a severe allergic reaction to immune globulin or other blood products. If you have such a history, discuss this with your healthcare provider to determine if GAMMAGARD LIQUID can be given to you. Tell your healthcare provider if you have a condition called selective (or severe) immunoglobulin A deficiency. GAMMAGARD LIQUID is made from human blood. It may contain infectious agents that can cause disease e.g., viruses, the variant Creutzfeldt-Jakob disease (vcjd), and theoretically, the Creutzfeldt-Jakob disease agent. Patients should report any symptoms that concern them which might be caused by virus infections. GAMMAGARD LIQUID can make vaccines (e.g., measles, mumps, rubella, or chicken pox vaccines) not work as well. It may also affect your blood test results. Before you get any vaccines or have your blood tested, tell your healthcare provider that you take GAMMAGARD LIQUID. The following is a list of common side effects seen in clinical trials of GAMMAGARD LIQUID (for Primary Immunodeficiency): IV administration: Headache, fatigue, fever, nausea, chills/shaking chills, pain in extremity, diarrhea, migraine, dizziness, vomiting, cough, hives, asthma, throat pain, rash, joint pain, muscle pain, swelling, itching, and cardiac murmur. Subcutaneous administration: Infusion site reactions (i.e., mild or moderate pain, swelling, itching, redness, bruising, and/or warmth), headache, fatigue, increased heart rate, fever, upper abdominal pain, nausea, vomiting, asthma, increased blood pressure, diarrhea, ear pain, canker sores, migraine, sore throat, and pain in extremity. Although it is possible to receive IV infusions at home, they are more often given in a hospital or infusion center by a nurse. Whenever giving yourself treatments at home, you should have another responsible person present to help treat side effects or get help should a serious adverse reaction occur. Ask your healthcare provider whether you should have rescue medications, such as antihistamines or epinephrine. Please see the accompanying full Prescribing Information, including the Patient Product Information. You may report side effects to the FDA at FDA-1088 or References: 1. HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant Human Hyaluronidase] [package insert]. Westlake Village, CA: Baxter Healthcare Corporation. 2. GAMMAGARD LIQUID [Immune Globulin Infusion (Human)] 10% [package insert]. Westlake Village, CA: Baxter Healthcare Corporation. 3. Blaese RM, Bonilla FA, Stiehm ER, Younger ME, eds. Patient & Family Handbook for Primary Immunodeficiency Diseases. 5th ed. Towson, MD: Immune Deficiency Foundation;

9 MyIgSource can help at diagnosis and throughout your PI journey. Insurance & Financial Support Enroll Today! Nurse Advocates MyIgSource.com Patient Advocates Educational Resources & Tools MyIgSource is open to all PI patients and caregivers regardless of treatment. Please see Indication and Detailed Important Risk Information on pages and and accompanying full Prescribing Information, including Boxed Warning. Baxter, Gammagard, Gammagard Liquid, Hyqvia and MyIgSource logo are trademarks of Baxter International Inc. August 2014 USBS/MG89/

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