Human Brain Project -

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1 Human Brain Project - Scientific goals, Organization, Our role Wissenswerte, Bremen 26. Nov 2013 Prof. Sonja Grün Insitute of Neuroscience and Medicine (INM-6) & Institute for Advanced Simulations (IAS-6) Juelich Research Centre & Theoretical Systems Neurobiology RWTH Aachen University

2 Goal: Understanding the Brain Understanding the human brain is still a great challenge Difficulty: its complexity E.g. Huge number of neurons (10 12 ) and synapses (10 4 ) per neuron connecting them Proper description level not yet clear 26. Nov 2013 Prof. Dr. Sonja Grün 2

3 Situation in Neuroscience Data deluge Data fragmentation No integration plan No data curation plan No plan to bridge levels No plan from animal to human Number of Peer Reviewed Publications on the Brain 26. Nov Prof. Dr. Sonja Grün 2012

4 EU FET (Future and Emerging Technologies) Flagships grand scientific and societal challenges which require a common European research effort science driven, large scale, multidisciplinary research initiatives oriented towards a unifying goal goals are visionary and highly ambitious require cooperation among a range of disciplines boosting European innovation sustained support for a period of up to 10 years substantial benefits for European competitiveness and society (EU flyer) 26. Nov 2013 Prof. Dr. Sonja Grün 4

5 Human Brain Project Flagship Started in Oct 2013, Kickoff summit in Lausanne Ramp-up phase (30 months): 54 million from EU Information and Communication Technologies (ICT) 2013 Work Programme Careful monitoring - report: every 6 months Operational phase: finance will come from the Horizon 2020 Research Programme 26. Nov 2013 Prof. Dr. Sonja Grün 5

6 26 6. N o v Human Brain Project Prof. Dr. Sonja Grün

7 Organization of HBP 26. Nov Prof. Dr. Sonja Grün

8 Organization of HBP Generate and analyze structural and functional data Mouse and human data from different levels derive general principles of brain organization deposit in publicly accessible brain atlases feed multi-level models 26. Nov 2013 Prof. Dr. Sonja Grün 8

9 Organization of HBP Investigate mathematical principles underlying brain organization Identify critical data needed for modeling Creation of European Institute for Theoretical Neuroscience 26. Nov Prof. Dr. Sonja Grün

10 Organization of HBP Build, operate and continuously update six ICT platforms Provide data storage and access, simulators, supercomputing, hardware simulators, robotics infrastructure Remotely accessible through a single HBP web portal 26. Nov Prof. Dr. Sonja Grün

11 Organization of HBP Projects that use platforms to accelerate research in neuroscience, medicine, and computing 26. Nov Prof. Dr. Sonja Grün

12 Organization of HBP Build ethical and social awareness among scientists Build and maintain dialogue with civil society Control compliance with ethical requirements 26. Nov Prof. Dr. Sonja Grün

13 The Consortium 20 European Countries 80 Institutions 150 PIs 2000 PhDs USA Israel Japan China Canada 26. Nov 2013 Prof. Dr. Sonja Grün 13

14 HBP as a large-scale scientific project, model: Large Hadron Collider (LHC) at CERN Basic Facts Construction: Consists of a 27km ring of superconducting magnets: Thousands of magnets of different varieties and sizes are used to direct the beams around the accelerator. These include 1232 dipole magnets 15m in length which bend the beams, and 392 quadrupole magnets, each 5 7m long, which focus the beams. Built in collaboration with over 10,000 scientists and engineers from over 100 countries, as well as hundreds of universities and laboratories. 26. Nov 2013 Prof. Dr. Sonja Grün 14

15 Build, Simulate and Validate Workbench through web portal Integrated workflow Access to platforms Provenance tracking 26. Nov 2013 Prof. Dr. Sonja Grün 15 15

16 Neuroinformatics Platform Provide brain atlases Providing data storage and curation Tools for the analysis of structural data Tools for the analysis of functional data Building consensus on data standards Technical support Data search, navigation and analysis portals Digital Atlases Curated data access, query and provenance Analysis Workflow s Brain Atlases Modeling Workflow s Analytic Service s International Federated Dataspace Simulatio n Workflow KnowledgeSpac s e Semantic Encyclopedia In cooperation with International Neuroinformatics Coordination Facility (INCF) 26. Nov 2013 Prof. Dr. Sonja Grün 16 16

17 WP Tools for the analysis of functional data (Sonja Grün, Jülich) Mitglied in in der Helmholtz-Gemeinschaft Develop and provide tools for Analysis of neuronal activity and dynamics evolving on networks of given structure and connectivity Integration of brain activity of different spatio-temporal scales (parallel single neuron activities, local field potentials) Simplification of interoperability of different analysis approaches Comparison of experimental and simulated data to test the predictive values of brain models Brain Activity and Behavior Behavior Network models 26. Nov 2013 Prof. Dr. Sonja Grün 17

18 Challenges To be successful, HBP requires scientists to: coordinate their research communicate across disciplines overcome differences of publication styles in the different communities communicate effectively provide detailed description of work perform reproducible research perform a paradigm shift to achieve the common goal: share 26. Nov 2013 Prof. Dr. Sonja Grün 18

19 Large-scale projects in Europe Nov 2013 Prof. Dr. Sonja Grün 19

20 26. Nov 2013 Prof. Dr. Sonja Grün 20

21 Governance Subproject 13: Project and programme management, education, dissemination and innovation Support HBP decision-making, operate the management structure and European Research Programme, ensure transparency and accountability towards funders and stakeholders, maintain standards of quality and performance 26. Nov 2013 Prof. Dr. Sonja Grün 21

22 Application: Future Neuroscience 26. Nov 2013 Prof. Dr. Sonja Grün 22