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1 ΒΙΟΓΡΑΦΙΚΟ ΣΗΜΕΙΩΜΑ: ΣΟΦΙΑ Γ. ΑΝΤΙΜΗΣΙΑΡΗ Ακολουθούν τα στοιχεία του βιογραφικού μου, στα Αγγλικά, όπως είχε πρόσφατα κατατεθεί σε πρόταση που υποβλήθηκε στο πρόγραμμα Αριστεία: I] Personal details / Education/ Affiliations Sophia G. Antimisiaris, Bpharm., Ph.D Current Position Professor of Pharmaceutics (2009-) and Lab Director (2002-), Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio, Greece Collaborating Faculty member, Institute of Chemical Engineering, ICEHT/FORTH (2006-to date) Personal Place and Date of Birth New Jersey, USA, 1962 Marital Status Married, two children Address Tel Fax Lab. Pharm. Technology, University of Patras, Rio 26510, Greece or santimis@upatras.gr Education Department of Pharmacy, University of Athens, Greece, Department of Pharmacy, University of Athens, Greece, Degree: BPharm (8.4/10) Degree: PhD (Biopharmaceutics) Supervisor: Prof. Panos Macheras Postdoctoral Research Assistant, School of Pharmacy, University of South California, Laboratory of Prof. Karl H.L. Hwang, Research on Liposomal Drug Delivery and Targeting. Affiliations: Lecturer of Pharmaceutics, Department of Pharmacy, UPAT (Sabbatical from UPAT) Visiting Professor, School of Pharmacy, University of London, Laboratory of Prof. Gregory Gregoriadis, Research on Liposomal Vaccine Delivery Assistant Prof, Department of Pharmacy, UPAT Associate Prof, Department of Pharmacy, UPAT Collaborating Member, Institute of Chemical Engineering, ICEHT-FORTH Research Activities: Nanomedicines: Liposomal or Nanoparticulate systems for Controlled Drug (or Vaccine) Delivery and/or Targeting Biopharmaceutics and Pharmacokinetics: Improving Drug Biodistribution and Pharmacokinetics through Advanced Drug Delivery System Design Application of novel lipid vesicles (Arsonoliposomes) in Anticancer / Antiparasitic Therapeutics. Novel Controlled-(Release)-Drug-Eluting Stents. Ocular, Alveolar and Vaginal Drug Delivery Systems Application of Liposomes in Analytical Techniques Participation in Research Projects: As coordinator/ or PI, in 1 National (PENED), 4 EU-funded (FP6/Interreg/FP7), and 3 industry funded projects (details below) 1

2 Publications: 75 papers in peer-reviewed journals (or series), 12 Invited Papers & Reviews or Chapters in Book Series, 120 Abstracts in proceeding of National, European and International conferences, 6 Papers in Greek Scientific Journals, 1 World patent, 1 PCT application, 1 US provisional patent, 1 European patent application (EPO).and 3 Greek patents. Books: 1 Textbook on Biopharmaceutics and Pharmacokinetics (in Greek) and 2 Practical course textbooks (in Greek). Corresponding author/pi: in >75% of published work. >800 citations (>600 in last 5 years) h-index 17 (14) Conference Participation/Attendance/Organisation: Participation in more than 90 International conferences or educational workshops, and more than 25 National conferences, Invited speaker in 30 National and International scientific or educational meetings/workshops/conferences. Organization of 4 Workshops (funded by Erasmus/Socrates and Marie Curie) 10-day Workshop Liposome Technology and Applications in Therapeutics and Nanomedicines for drug delivery ( , ; 2003; 2008); Member of organizing committee (or regional committee) of 6 international conferences. Teaching Activities: Undergraduate Courses: Biopharmaceutics and Pharmacokinetics (+Practical course); Pharmaceutical Technology: Pre Formulation / Design and Preparation of Drug Formulation.(+Practical course) Postgraduate Courses: Liposome Technology; Applied Pharmacokinetics, Determination of Drugs in Biological Fluids, Pharmaceutical Statistics, Advanced-Novel Pharmaceutical Formulations (Liquid, Semi-Solid, Solid) Prizes-Honors: : Scholarships from Greek State Scholarships Foundation (IKY) for outstanding performance during undergraduate studies (Ranking in top 5% of class) : Research Fellowship, University of South. California (NIH), L.A, USA : Research Fellowship, University of London (from MOD funded project), London, UK. 2011: First place young investigator award to my student for our poster at EuroNanoForum 2011, May 30 June 1, Budapest, Hungary. Professional Affiliations: - Panhellenic Association of Pharmacists - APGI/APV (Association de Pharmacie Galenique Industrielle) - European Federation of Pharmaceutical Scientists (EUFEPS) -AAPS (Americal Association of Pharm. Scientists) - Controlled Release Society (CRS) - CRS -Greek Chapter [President ] - International Liposome Society (ILS) - Galenos Network for novel Drug delivery Exploitation and Education Professional Activities: Associate Editor Europe for the Jourmal of Biomedical Nanotechnology (2006-). Member of Editorial Board of Journal of Drug Delivery (2010 -). Referee for 35 Pharmaceutical and related Scientific journals. Participation in 3 EU Research Proposal Evaluator panels, EC Research Directorate, 2003, 2004 (FP6) and 2007 (FP7). Evaluator for the Spanish Ministry of Development and Research (after invitation) 2006; Evaluator for a number of foundations (TWAS, Israel Research Council, British cancer Res. Found., Dutch res found., etc.) President of the Western-Greece Committee for evaluation of Pharmacy Technicians (2001-). Evaluator for National Foundation of Drugs (EOF): Bioequivalence Study reviewer (2000-). Scientific Committee Member of European Association of Pharma Biotechnology [EAPB] (2004). Member of Scientific Advisory Board Europe, of official publication of EAPB (2004). Member of the Senate, Univ. of Patras (2004-5). Member of the Graduate Studies committee, Dept. of Pharmacy, Univ. of Patras (1998-). Coordinator of the Erasmus mobility Program for the Dept. of Pharmacy, Univ. of Patras (1998-). 2

3 II] List of most significant publications (maximum 2 pages) P. Macheras, M.Koupparis, S.G.Antimisiaris, Drug Binding and Solubility in Milk, Pharm. Research, 8, 537, 1990 S. G. Antimisiaris, Jayesekera,P., Gregoriadis,G., "Liposomes as vaccine carriers: Incorporation of soluble and particulate antigens in giant vesicles", J. Immunol. Methods, 166, 271,1993 M. Kokona, P. Kallinteri, D. Fatouros, S.G. Antimisiaris*, Stability of SUV liposomes in the presence of cholate salts and pancreatic lipases: Effect of lipid composition. Eur. J. Pharm. Sciences (EJPS), 9, 245, 2000 E. Papadimitriou and S.G. Antimisiaris*, Interactions of PC/Chol and PS/Chol liposomes with human cells in vitro, J. Drug Targeting, 8:5, 335, 2000 D. Fatouros, S.G. Antimisiaris*, Physicochemical properties of liposomes incorporating hydrochlorothiazide and chlorothiazide, J. Drug Targeting, 9:1, 61-74, 2001 P. Kallinteri, W-Y. Liao, S.G. Antimisiaris* and K.H.L. Hwang, Characterization, Stability and in-vivo distribution of Fetuin F2 glycopeptide incorporating DSPC/Chol liposomes prepared by mild cholate incubation, J.Drug Targeting, 9:2, 155, D. Fatouros, O. Gortzi, P. Klepetsanis, S.G. Antimisiaris*, etal. Preparation and properties of arsonolipid containing liposomes, Chem. Phys. Lipids, 109, 75-89, Fatouros, K. Haztidimitriou, S.G. Antimisiaris*, Liposomes encapsulating prednisolone and prednisolonecyclodextrin complexes: comparison of membrane integrity and drug release, EJPS, 13, 287, 2001 P.Kallinteri, S. G. Antimisiaris*, Solubility of drugs in the presence of gelatin: effect of drug lipophilicity and degree of ionization, Int. J. Pharm., 221, , O.Gortzi, P. Klepetsanis, S.G. Antimisiaris*, P. V. Ioannou, Capability of arsonolipids to transport divalent cations: A pressman cell study, Chem. Phys. Lipids, 112, 21, P.Kallinteri, E. Papadimitriou, S.G. Antimisiaris*, Targeting of small unilamellar liposomes bearing asialofetuin glycopeptide conjugates to HepG2 cells, J. Liposome. Res., 11(2&3), 175, 2001 O. Gortzi, E. Papadimitriou, S G. Antimisiaris* P. Ioannou, Arsonoliposomes, a novel class of arsenic containing liposomes: Effect of palmitoyl-arsonolipid containing liposomes on the viability of various cancer and normal cells in culture, Pharm. Research, 19:1, 79, P. Kallinteri, S.G.Antimisiaris*, etal. Dexamethasone incorporating liposomes: An in vitro study of their applicability as a slow release delivery system of dexamethasone from covered metallic stents, Biomaterials, 23, 4819, O Gortzi, E. Papadimitriou, S.G. Antimisiaris* P. Ioannou, Cytotoxicity of arsonolipid containing liposomes towards cancer and normal cells in culture: Effect of arsonolipid acyl chain length, EJPS, 18, 2, 175,2003 P. Kallinteri, D. Fatouros, P. Klepetsanis, S.G. Antimisiaris*, Arsenic trioxide liposomes.encapsulation efficiency and in vitro stability, J. Liposome Res., 14 (1-2): 27, 2004 Antimisiaris SG*, Klepetsanis P, Zachariou V, et al. In vivo distribution of arsenic after i.p. injection of arsonoliposomes in balb-c mice. Int J Pharm 289 (1-2): 151, Fatouros DG, Piperoudi S, Gortzi O, Ioannou PV, Antimisiaris SG.*. Physical stability of sonicated arsonoliposomes: Effect of calcium ions. J Pharm Sci-US 94, 46, 2005 Fatouros DG, Klepetsanis P, Ioannou PV, Antimisiaris SG. The effect of ph on the electrophoretic behaviour of a new class of liposomes: arsonoliposomes. Int J Pharm 288 (1): 151, 2005 S.Piperoudi, P.V.Ioannou, P.Frederik, S.G.Antimisiaris*, Arsonoliposomes: Effect of lipid composition on their stability. J Liposome Res 15 (3-4): S. Piperoudi, D. Fatouros,.., S.G. Antimisiaris,*, Incorporation of PEG-lipids in arsonoliposomes can produce highly stable arsenic-containing vesicles of specific lipid composition. Chem. Phys. Lipids 139:2, , G. Koromila, G. Michanetzis, Y.F. Missirlis, S.G.Antimisiaris*, Heparin incorporating liposomes as a delivery system of heparin from PET-covered metallic stents, Biomaterials, 27:12, 2525, 2006 S. Koutsopoulos, DG. Fatouros, PV. Ioannou, SG Antimιsiaris. Thermal behaviour of non-sonicated arsonolipid Dispersions. Biophysical Chemistry, 121:2, 150, 2006 M. Haikou, P. Zagana, PV, Ioannou, SG. Antimisiaris*. Arsonoliposome Interaction with thiols. Effect of pegylation and arsonolipid content on their integrity during incubation in the presence of glutathione. J. Nanosc & Nanotech, 6:2974, 2006 V. Ntimenou, S. Mourtas, E. Christodoulakis, M. Tsilimbaris, S.G. Antimsiaris*. Stability of protein encapsulating DRV liposomes after freeze drying: study with BSA& t-pa. J Liposome Res, 16, 4, , 2006 P. Hatzi, S. Mourtas, P. Klepetsanis, S.G Antimisiaris*. Integrity of liposomes in presence of cyclodextrins. Effect of liposome type and lipid composition, Int. J. Pharm,333 (1-2), pp. 167, S. Mourtas, S. Fotopoulou,.., S.G. Antimisiaris*. Liposomal drugs dispersed in Hydrogels. Effect of liposome, drug and gel properties on drug release kinetics. Colloids and Surf B: Biointerfaces (CS B), 55 (2), pp. 212,

4 M. Zaru, S. Mourtas, P. Klepetsanis, A.M. Fadda and S.G.Antimisiaris*, Liposomes for drug delivery to the lungs after nebulization. Eur. J. Pharmaceut & Biopharm (EJBP), 67 (3), 655, 2007 P. Zagana, P. Klepetsanis, PV. Ioannou, P M. Loiseau, S.G. Antimisiaris* Trypanocidal activity of arsonoliposomes: Effect of vesicle lipid composition, Biomed & Pharmacoth, 61, 499,2007 P. Zagana, M. Haikou, P. Klepetsanis, E. Giannopoulou, P.V. Ioannou, S.G. Antimisiaris*, In vivo distribution of arsonoliposomes: Effect of vesicle lipid composition, Int. J. Pharm, 347 (1-2), 86, 2008 S. Mourtas, S. Duraj, S. Fotopoulou, S.G. Antimisiaris*. Integrity of liposomes in presence of various formulation additives, in aqueous dispersions and in hydrogels, CS B: Biointerfaces, 61 (2), 270, 2008 M-L Manca, S Mourtas, V Drakopoulos, A M Fadda, S G.Antimisiaris*, PLGA, Chitosan or Chitosan-coated PLGA Microparticles for Alveolar Delivery? CS B: Biointerfaces, 62 (2), 220, 2008 S Mourtas, M Haikou, M Theodoropoulou, C Tsakiroglou, S G. Antimisiaris*, How liposome type, composition and loading concentration influence the rheological properties of a liposomal gel. J. Colloid & Inter. Scienc, 317 (2), , 2008 C. Peptu, M. Popa, S.G. Antimisiaris*, Release of Liposome-Encapsulated Calcein from Liposome Entrapping Gelatin- Carboxymethylcellulose Films. J. Nanoscience & Nanotechnology, 8, 2249, M L Manca, G Loy, M Zaru, AM Fadda, SG. Antimisiaris* Release of Rifampicin from Chitosan, PLGA and Chitosan-coated PLGA microparticles, CS B: Biointerfaces, 67, 166, 2008 M Zaru, M-L Manca, A M Fadda S.G. Antimisiaris* Chitosan-coated liposomes for delivery to lungs by nebulization. CS B: Biointerfaces 71 (1), 88, 2009 S. Mourtas, C. Aggelopoulos, P. Klepetsanis, C. Tsakiroglou, S.G. Antimisiaris*, Complex gel formulations for topical drug administration: Rheological properties and aging, Langmuir, 25 (15), pp. 8480, 2009 Favretto, M.E., Marouf, S., Ioannou, P., Antimisiaris, S.G., Parker, T.L. Kallinteri, P. Arsonoliposomes for the potential treatment of medulloblastoma, Pharm. Research 26 (10), 2237, 2009 G. Besson,.., S. Mourtas,.., S. Antimisiaris, M. Kazanji Protective properties of non-nucleoside reverse transcriptase inhibitor (MC1220) incorporated into liposome against intravaginal challenge of Rhesus Macaques with RT SHIV, Virology 405 (1), 225, 2010 E Markoutsa, G Pampalakis,.., S. G. Antimisiaris*, Uptake and permeability studies of BBB-targeting immunoliposomes using the hcmec/d3 cell line, EJPB, 77: 2, 265, 2011 S. Mourtas, M. Canovi,.., M. Gobbi, S. G. Antimisiaris*, Curcumin-decorated nanoliposomes with very high affinity for amyloid-b1-42 peptide, Biomaterials, 32: 6, 1635, 2011 S. Mourtas, M. KastelloriziosP. Klepetsanis, ( ), S. Antimisiaris*. Immobilization of liposomes on Plasma-treated stainless steel surfaces, by covalent binding. CS B: Biointerfaces, 84 (1), 214, 2011 Canovi, M., Markoutsa, E., Lazar, A.N.,.., Antimisiaris, S.G*.The binding affinity of anti-aβ1-42 MAb-decorated nanoliposomes to Aβ1-42 peptides in vitro and to amyloid deposits in post-mortem tissue. Biomaterials 32, 5489, 2011 Stolte-Leeb N, Loddo R, Antimisiaris S, Schultheiss T, Sauermann U, Franz M, Mourtas S, Parsy C, Storer R, Colla PL, Stahl-Hennig C Topical Nonnucleoside Reverse Transcriptase Inhibitor MC 1220 Partially Prevents Vaginal RT-SHIV Infection of Macaques. AIDS Res Hum Retroviruses Mar 23. [Epub] M-T Popescu, S Mourtas, G Pampalakis, S G. Antimisiaris, C Tsitsilianis. ph-responsive Hydrogel/Liposome Soft Nanocomposites For Tuning Drug Release, Biomacromolecules, Articles ASAP July 5, 2011; S. Mourtas, P. Klepetsanis, ( ),S.G. Antimisiaris*. Liposomal gels for vaginal delivery of the microbicide MC1220: Preparation and in vivo vaginal toxicity and pharmacokinetics,.nanolife, accepted, 2011 A.Skouras, S. Mourtas, E. Markoutsa, M-C. De Goltstein, C Wallon, S Catoen, SG. Antimisiaris*. USPIO encapsulating nanoliposomes with high entrapping efficiency, stability and magnetic properties. Nanomedicines (Nanotechnology, Medicine and Biology), in press, M. Taylor, S Moore, S Mourtas, A Niarakis,.., S G Antimisiaris, M Gregori, David Allsop. Effect of curcuminassociated and lipid ligand functionalised nanoliposomes on aggregation ofthe Alzheimer's Aβ peptide. Nanomedicines(Nanotechnology, Medicine and Biology), in press, Book Chapters : G. Gregoriadis, I. Gursel and S.G. Antimisiaris, "Microbe entrapment in giant Liposomes", In : Nonmedical Applications of Liposomes (eds. L. Lasic and Y. Barenholz) CRC-Press, Boca Raton, pg , 1996 S. G. Antimisiaris*, D. Fatouros and P. Kallinteri. Invited Chapter on Liposome Technology, for the Pharmaceutical Manufacturing Handbook, Section 5: New Dosage Forms, Chapter 5.3, Eds. John Wiley and Sons, pp , 2008 S. G. Antimisiaris*. Liposomes in Drug Delivery. Invited chapter for Encyclopedia of Nanoscience and Nanotechnology,

5 III] Significant research achievements in last 10 years (publications, invited talks, patents, awards) A. Publications in high ranking journals: 4 publications in Biomaterials [IF 7.882] (2002, 2006, 2011, 2011) (ranking first in its category) Other journals with IF>3 : Biomacromolecules [IF 5.325] (2011), Nanomedicine (Nanotechnology, Medicine and Biology) [IF 4.882] (2011, 2011), Mol Nutr & Food Res [IF 4.713] (2009) Pharmaceutical Research [IF 4.456] (2002, 2009); EJPB [IF 4.304](2007, 2011), Langmuir (2009) [IF 4.268], International Journal of Pharmaceutics [IF 3.607] (2001, 2005, 2005, 2007, 2008), Virology [IF 3.305] (2010), EJPS [IF 3.291](2001, 2003), J. Coll & Inter Sciences [IF 3.066] (2008), J Pharm Sciences (US) [IF 3.031] (2005), B. Invited publications: Fatouros, PV Ioannou, SG Antimisiaris*. Novel Nanosized Arsenic Containing Vesicles for Drug Delivery: Arsonoliposomes. (Invited Review article) J. Nanoscience & Nanotechnology, 6: , 2006 S.G.Antimisiaris*, G. Koromila, G. Michanetzis, Y.F. Missirlis, Liposome coated stents: A method to deliver drugs to the site of action and improve stent blood-compatibility. (Invited paper) Journal of Liposome Research, Volume 16, 3, , 2006 S.G.Antimisiaris, Arsonoliposomes for Drug Delivery, (Invited Review article) J. Drug Del Scienc & Techn 17, , 2007 Guest Editor for. A Special Issue on Nanomedicines, J. Biomed. Nanotechnol. 4, 217, 2008 P. Zagana, M. Haikou, E. Giannopoulou, P.V. Ioannou, S.G. Antimisiaris*, Arsonoliposome Interaction with cells in culture. Effect of pegylation and lipid composition. (Invited paper for special issue on arsenic), Mol. Nutr. Food Res. 53, , 2009 Antimisiaris, S.G. Arsonoliposomes for drug delivery applications, (invited review) Clinical Lipidology 4 (5), pp , 2009 S. Mourtas, C. Aggelopoulos, P. Klepetsanis, C. Tsakiroglou, S.G. Antimisiaris*, Complex gel formulations for topical drug administration: Rheological properties and aging, (invited paper for special issue on Gels) Langmuir, 25 (15), pp. 8480, 2009 S.G.Antimisiaris, Preparation of DRV liposomes, (invited contribution) Methods in molecular biology (Clifton, N.J.) (2010), 605, ISBN: S.G.Antimisiaris*, P.V. Ioannou, Arsonoliposomes: preparation and physicochemical characterization, (invited contribution) Methods in molecular biology (Clifton, N.J.) (2010), 605, ISBN: S. Mourtas, P. Klepetsanis, ( ),S.G. Antimisiaris*. Liposomal gels for vaginal delivery of the microbicide MC1220: Preparation and in vivo vaginal toxicity and pharmacokinetics, (invited paper for special issue) NanoLife, accepted, 2011 C. Invited Talks: 30 invited talks (from 2001-) in International Conferences, Seminars, Intensive Programs/Workshops or Summer Schools (some listed below): Liposome applications in Transdermal delivery. Socrates IP on Dermal delivery of drugs. University Claude-Bernard I, Dept of Pharmacy, Lyon Sept Liposomes and Cyclodextrins. Socrates IP on Cyclodextrins. University of Lisbon, Dept of Pharmacy, Sept Liposome coated stents: A method to deliver drugs to the site of action and improve stent bloodcompatibility. ILS Conference on Liposome Advances: Progress in Drug and Vaccine Delivery, December, London, 2005 Liposome technology Revisited. In 6th International conference and Workshop on Cell culture and in vitro Models for drug Absorption and Delivery, Theme day: Impact of Nanobiotechnology on New medicines. Saarbruecken, Germany, March 1-10, Liposomes and transdermal delivery of drugs: Incorporation in hydrogels. In Socrates IP on Dermal delivery of drugs. University Claude-Bernard I, Department of Pharmacy, Lyon, September 2006 Controlled release drug delivery systems for intravitreal administration: What can Liposomes do? In Aegean Retina X, July 6-8, Rhodes, GR,

6 Liposomes as a system to prepare Controlled Drug Eluting Biomaterials, in 2nd Interreg School on Advanced Biomaterials, Bari, Italy, May, 2008 Drug Delivery and Targeting Systems- Focus on Liposomes. In Nano2Life Summer School Methods in Micro-Nanotechnology and Nanobiotechnology, (Lecture July 8, 2008), Demokritos, Athens, Greece, Controlled release DDS for Ocular Delivery: Focus on Liposomes, in Seminars on Optics and Vision, Herakleio, Crete, July 8-9, 2008 Arsonoliposomes in Drug Delivery, in 6th Euro Fed Lipids Congress (Oils, Fats & Lipids in the third Millenium). Session: Lipids in Pharmaceutics, Sept. 7-10, Athens, 2008 Liposomes in nanomedicines, in DIMET COURSE Nanoparticles in Medicine Università degli Studi di Milano Bicocca,, MILANO, March 11-13, Nanosized liposomes for on -site controlled-release of active agents, in 5th International Biotechnology Forum (IBSF5), Athens, May 8-9, Nanosized liposomes for construction of drug eluting stents: Improving blood compatibility. In International Conference: From Drug Delivery Systems to Drug Release, Dissolution, IVIVC, BCS, BDDS, Bioequivalence and Biowaivers, May 28-30, Athens Greece, Covalently immobilized liposomes for development of controlled release drug-eluting surfaces: Potential for blood compatibility. in Liposome Advances : Progress in Drug and Vaccine Delivery, Dec , London, UK,2010 Nano-Immunoliposomes for Blood-Brain Barrier (BBB) targeting, in EUROBIC Conference, Thessaloniki, June 2010 Immunoliposomes for Drug Targeting Applications: Results with OX- 26 antibody for Brain Targeting; Intern. Conference on: New Drug Delivery systems, Biosimilars, Bioequivalence, Athens, July 2-3, 2010 Nanoparticulate Drug Delivery systems: Description and Applications, University of Oslo (invited Lecture), September 8, 2010, Oslo Nanoliposomes for targeting AD with therapeuticand diagnostic potential, (Round Table on Nanotechnologies) Panhellenic Pharmaceutical Conference, May 2011, Athens Development of novel nanoparticles with high affinity for Aβ1-42 peptides; 7th Panhellenic International Medical Comference on Alzheimers disease and Related Pathologies, Thessaloniki, February 16-20, 2011 Invited Speaker in Liposome Conference (ILS Society), London Dec 10-13, 2011 D. Patents Liposomes containing particulate materials. WO (A1) Publication date: US Inventor(s): G. Gregoriadis, S.G. Antimisiaris, I. Gursel. A method for immobilization of bioactive substances on surfaces for improving haemocompatibility. Greek Patent, 2006, Inventor(s): S. G. Antimisiaris, I. Missirlis, G. Michanetzis, G. Koromila. Complex formulations for administration of microbicides or other categories of drugs via mucosal (or vaginal or rectal) routes, with high drug-loading capacity and controllable drug release rates. Greek Patent, , 2009, Inventor(s): S.G.Antimisiaris, P.Klepetsanis, S. Mourtas Treatment of Prostate tumors with arsonoliposomes, US Provisional Patent US 61/324,547, April , Inventors: S.G. Antimisiaris, P.V. Ioannou, M. Wei Novel curcumin derivatives with improved physicochemical properties and surface-decorated Nanoliposomes (with the derivatives) with very high affinity for Amyloid-β1-42 peptide. Greek Patent , 2010, [EPO filed] Inventor(s): S.G.Antimisiaris, F. Nicotra, S. Mourtas, C. Zona, B. LaFerla, A. Niaraki. E. Awards: 2011: First place young investigator award to my student A. Skouras for our poster at EuroNanoForum 2011, May 30 June 1, Budapest, Hungary. 6

7 IV] List other Research Projects in which PI has participated in the last 10 years. Funded Research Project SGA has participated in during the last 10-year period ( ): Selection and Development of a microbicide formulation for the prevention of sexual distribution of HIV Large Scale Integrated Project in HEALTH call (FP6) SHIVA ELKE: B227 EC (FP6, Health) PI for UPAT, (Vice-coordinator, WP-leader) Start/End: 450 K euro (Total M euro) 2004/2009 (SHIVA received a 1 year cost-neutral prolongation) Selection and Development of a microbicide formulation for the prevention of sexual distribution of HIV (Matching Funds) SHIVA ELKE: B456 Matching Funds (FP6) Coordinator 89 K euro Start/End: Towards a Euro PhD in Advanced Drug Delivery systems Marie Curie Project in : Early Stage PhD scholarships (FP6) Euro-PhD ELKE: B296 EC (FP6, Marie Curie) PI for UPAT, (WP-leader and Host Lab) 120 K euro (Total 8.10 M euro) Start/End: Towards a Euro PhD in Advanced Drug Delivery systems (Matching Funds) Euro-PhD ELKE: B467 Matching Funds (FP6) Coordinator 19 K euro Start/End: 2004 / 2008 Establishment of A Multidisciplinary Scientific Network For The Development And Application Of Biomaterials - ELKE: B277 EC (INTERREG IIIa Greece-Italy) Partner of UPAT group/ PI for Pharm-TECH, (WP-leader) 110 K euro (Total 1.10 M euro) Start/End: 2006 /

8 6 7 8 Nanomedicines: Nanoparticulate for Drug Delivery (for organization of Intensive Program - Workshop) IP-Nano ELKE: C512 EC (LLL-Erasmus) Coordinator 41 K euro Start/End: Nanoparticles for Therapy and Diagnosis of Alzheimer Disease Large scale project in NMP(Nanotechnology-Materials-Processes) NAD ELKE: C510 EC (FP7, NMP) PI for UPAT, (WP-leader) 785 K euro (Total 14.7 M euro) Start/End: 2008 / 2013 Nanoparticles for Therapy and Diagnosis of Alzheimer Disease MATCHING FUNDS NAD ELKE: C977 Matching Funds (FP7) coordinator K euro Start/End: 2008/ 8

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