List of Graphs. levels Effect of antioxidants on phenytoin induced alterations in GSH levels
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1 List of Graphs Page 1 Effect of antioxidants on phenytoin induced alterations in RBC count Effect of antioxidants on phenytoin induced alterations in haemoglobin levels Effect of antioxidants on phenytoin induced alterations in total leukocyte count Effect of antioxidants on phenytoin induced alterations in platelet count Effect of antioxidants on phenytoin induced alterations in packed cell volume Effect of antioxidants on phenytoin induced alterations in SOD levels Effect of antioxidants on phenytoin induced alterations in catalase activity Effect of antioxidants on phenytoin induced alterations in GSH levels Effect of antioxidants on phenytoin altered Vitamin C levels Effect of antioxidants on phenytoin induced alterations in total antioxidant status Effect of antioxidants on phenytoin enhanced lipid peroxidation Effect of Vitamin C on phenytoin induced memory impairment Effect of Vitamin C on phenytoin impaired exploratory activity Effect of Vitamin C on phenytoin induced motor in-coordination Effect of Vitamin C on phenytoin impaired locomotor activity Effect of Vitamin C on phenytoin induced alterations in regional brain lipid peroxidation Effect of Vitamin C on phenytoin induced alterations in regional brain acetyl cholinesterase activity vi
2 18 Effect of Vitamin E on phenytoin induced memory impairment Effect of Vitamin E on phenytoin impaired exploratory activity Effect of Vitamin E on phenytoin induced motor in-coordination Effect of Vitamin E on phenytoin impaired locomotor activity Effect of Vitamin E on phenytoin induced alterations in regional brain lipid peroxidation Effect of Vitamin E on phenytoin induced alterations in regional brain acetyl cholinesterase activity Effect of ALA on phenytoin induced memory impairment Effect of ALA on phenytoin impaired exploratory behaviour Effect of ALA on phenytoin induced motor in-coordination Effect of ALA on phenytoin impaired locomotor activity Effect of ALA on phenytoin induced alterations in regional brain lipidperoxidation Effect of ALA on phenytoin induced alterations in regional brain acetyl cholinesterase activity Effect of NAC on phenytoin induced memory impairment Effect of NAC on phenytoin impaired exploratory behaviour Effect of NAC on phenytoin induced motor in-coordination Effect of NAC on phenytoin impaired locomotor activity Effect of NAC on phenytoin induced alterations in regional brain lipidperoxidation Effect of NAC on phenytoin induced alterations in regional brain acetyl cholinesterase activity vii
3 36 Effect of antioxidants on phenytoin induced alterations in SGOT levels Effect of antioxidants on phenytoin induced alterations in SGPT levels Effect of antioxidants on phenytoin induced alterations in Total Bilirubin levels Effect of antioxidants on phenytoin induced alterations in ALP levels Effect of antioxidants on phenytoin induced alterations in Albumin levels Effect of antioxidants on phenytoin induced alterations in Total protein levels Effect of antioxidants on phenytoin enhanced liver lipid peroxidation Effect of antioxidants on phenytoin induced hyperglycemia Effect of antioxidants on phenytoin induced alterations in Total Cholesterol levels Effect of antioxidants on phenytoin induced alterations in Triglyceride levels Effect of antioxidants on phenytoin induced alterations in LDL levels Effect of antioxidants on phenytoin induced alterations in VLDL levels Effect of antioxidants on phenytoin induced alterations in HDL levels Standard graph of phenytoin Pharmacodynamic interactions of selected antioxidants with phenytoin viii
4 List of Figures Page 1 Role of ALA in recycling other antioxidant systems Effect of phenytoin on regional brain histopathology 2a Control b Phenytoin c Phenytoin Effect of Vitamin C on phenytoin induced alterations in brain histopathology 3a Phenytoin + Vit C (50 mg/kg) b Phenytoin + Vit C (100 mg/kg) c Phenytoin + Vit C (200 mg/kg) Effect of Vitamin E on phenytoin induced alterations in brain histopathology 4a Phenytoin + Vit E (50 mg/kg) b Phenytoin + Vit E (100 mg/kg) c Phenytoin + Vit E (200 mg/kg) Effect of ALA on phenytoin induced alterations in brain histopathology 5a Phenytoin + ALA (50 mg/kg) b Phenytoin + ALA (100 mg/kg) c Phenytoin + ALA (200 mg/kg) Effect of NAC on phenytoin induced alterations in brain histopathology 6a Phenytoin + NAC (50 mg/kg) b Phenytoin + NAC (100 mg/kg) c Phenytoin + NAC (200 mg/kg) Gross macroscopy liver 7a Control b Phenytoin ix
5 8 Effect of phenytoin on liver histopathology 8a Control b Phenytoin c Phenytoin Effect of Vitamin C on phenytoin induced alterations in liver histopathology 9a Phenytoin + Vit C (50 mg/kg) b Phenytoin + Vit C (100 mg/kg) c Phenytoin + Vit C (200 mg/kg) Effect of Vitamin E on phenytoin induced alterations in liver histopathology 10a Phenytoin + Vit E (50 mg/kg) b Phenytoin + Vit E (100 mg/kg) c Phenytoin + Vit E (200 mg/kg) Effect of ALA on phenytoin induced alterations in liver histopathology 11a Phenytoin + ALA (50 mg/kg) b Phenytoin + ALA (100 mg/kg) c Phenytoin + ALA (200 mg/kg) Effect of NAC on phenytoin induced alterations in liver histopathology 12a Phenytoin + NAC (50 mg/kg) b Phenytoin + NAC (100 mg/kg) c Phenytoin + NAC (200 mg/kg) Blank Chromatogram Chromatogram of Control Chromatogram of Phenytoin (standard) Chromatogram of Phenytoin supplemented with Vitamin C Chromatogram of Phenytoin supplemented with Vitamin E Chromatogram of Phenytoin supplemented with Alpha Lipoic Acid Chromatogram of Phenytoin supplemented with N Acetyl Cysteine x
6 List of Tables Page 1 Effect of phenytoin and phenytoin + Vitamin C on body weight, absolute and relative liver weight Effect of phenytoin and phenytoin + Vitamin E on body weight, absolute and relative liver weight Effect of phenytoin and phenytoin + ALA on body weight, absolute and relative liver weight Effect of phenytoin and phenytoin + NAC on body weight, absolute and relative liver weight Phenytoin Concentration Vs Peak Area Effect of antioxidants on serum phenytoin levels xi
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