DISCIPLINE RECORD/ COURSE / SEMINAR DESCRIPTION
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1 Universitatea de Medicină şi Farmacie Grigore T. Popa Iaşi Comisia pentru asigurarea calităţii DISCIPLINE RECORD/ COURSE / SEMINAR DESCRIPTION 1. Information about the program UNIVERSITY: GRIGORE T. POPA UNIVERSITY OF MEDICINE AND PHARMACY OF 1.1. IAŞI 1.2. FACULTY: PHARMACY SCHOOL / DEPARTMENT: PHARMACEUTICAL SCIENCES II 1.3. SUBJECT: PHARMACODYNAMICS AND CLINICAL PHARMACY 1.4. STUDY FIELD: PHARMACY 1.5. STUDY CYCLE: UNDERGRADUATE 1.6. STUDY PROGRAMME: IN ENGLISH 2. Subject data 2.1. SUBJECT: PHARMACODYNAMICS 2.2. Module leader: Assoc. Prof. Veronica Bild, PhD 2.3. Seminar leader: Assoc. Prof. Veronica Bild, PhD, Assis. Prof. Monica Neamţu, PhD 2.4. Year of study III 2.5. Semester in which is taught II 2.6. Evaluation type E Subject status Compulsory 3. Duration of the course (hours per semester) 3.1. Number of Number of Seminar / lab 1 hours / week hours / week 3.4.Total number of learning hours Total number of learning hours seminar / lab Distribution of activities in the course hours Study based on the manual, printed course, bibliography and notes 15.5 Additional research in the library, on specialized e-platforms and field study 2 Preparation for seminars, practical courses, portfolios and essays 4 Tutoring 0.5 Assessment - Other activities Number of hours of individual study Number of hours per semester Number of ECTS 2 4. Previous Knowledge (if applicable) 4.1. course related Anatomy, Physiology, Pathophysiology, Biochemistry skill related Theoretical knowledge of anatomy, physiology and pathophysiology of organs and systems, concepts of biopharmaceutics, laboratory skills, techniques of harvesting and management of biological samples in laboratory animals and humans, pharmaceutical calculations.
2 5. Requirements (if applicable) 5.1. course conditions Audio-video equipment seminar / laboratory conditions Audio-video equipment, special room arranged to carry out experiments on laboratory animals, experimental animals, laboratory glassware, specific laboratory instruments. 6. Specific Skills Acquired Professional skills displayed by knowledge and skills Transversal skills (role skills, professional and personal skills) Storage, preservation and distribution of medicines, food supplements, cosmetics and other health care products Dispense prescribed medicines, food supplements, cosmetics, other health care products and pharmaceutical care Consultancy and expertise in the field of medicines, food supplements, cosmetics and other health care products Learning some basic notions of regarding: drug dosage, identifying incompatibilities between drugs, identifying the types of interactions regarding drug associations, highlighting some factors that influence the absorption, metabolism and elimination of drugs, knowledge of pharmacodynamic parameters. Autonomy and responsibility - the execution of some complex educational tasks under conditions of autonomy. Social interaction and teamwork - assuming the roles / functions of leadership of working or research teams, learning group work. Respect and development of professional values and ethics. Problem solving and decision making. Recognize and respect for diversity and multiculturalism. Openness to lifelong learning. 7. Course Objectives (confirmed by the grid of specific skills acquired) 7.1. General Objective Learning the basics on the first two chapters of general part of pharmacology: general pharmacokinetics and pharmacodynamics 7.2. Specific Objectives Pharmacokinetics steps, pharmacodynamic action parameters 8. Contents 8.1. Course Teaching methods Observations 1. Pharmacology (definition); branches of Lecture, open discussion, 0.5 hours pharmacology; the drug (definition) correlation with notions acquired 2. General pharmacokinetics: 2.1. Pharmacokinetics (definition), pharmacokinetics stages, the availability of the drugs (phases); drug bioavailability; biopharmacy 2.2. Drug passage through biological Lecture, open discussion, correlation with notions acquired 1.5 hours
3 membranes 2.3. Drug absorption 2.4. Drug transport in the blood 2.5. Drug diffusion and distribution in the organism 2.6.Drug biotransformation 2.7.Drug elimination from the organism 3. General pharmacodynamics: 3.1. Pharmacodynamic action (primary action, pharmacodynamic effect); 3.2. Parameters of the pharmacodynamic action: sense, potency, efficacy (maximum efficacy), selectivity, latency, time of maximum effect, duration Lecture, open discussion, correlation with notions acquired 7 hours 3.3. Action site (drug action at the molecular level: receptorspharmacoreceptors and drug-receptor interactions; classes-super-families of receptors); type of action 3.4. Factors influencing the action of drugs; drug-depending factors; organismdepending factors; factors depending on other conditions Bibliography 1. Cristea AN. Farmacologie generală. Bucureşti: Editura Didactică şi Pedagogică, Goodman & Gilman s. The Pharmacological Basis of Therapeutics. New York: McGraw-Hill, Med Div, Katzung BG. Basic and Clinical Pharmacology, Eleventh Edition. New York: McGraw-Hill, Med. Div., Rang HP, Dale MM, Ritter JM, Flower RJ. Rang and Dale s Pharmacology, Sixth Edition. London: Churchill Livingstone Elsevier, Seminar / Practical lessons Teaching Methods Observations 1. Concepts and introductory notions regarding the pharmacodynamics study of the drug. Experimental methods in pharmacodynamics. Labor protection 2. Measure units used in drug preparation and administration. Concentrations. Drug dosage. Prescription writing 3. General pharmacokinetics. The variation of absorption in relation to the administered pharmaceutical form. The concept of bioavailability. Biopharmacy Lecture, open discussion Lecture, open discussion, practical applications of concepts techniques used, interpretation of the data and their experimental and 4. General pharmacokinetics. The variation of drug absorption rate
4 according to the concentration or the route of administration 5. General pharmacokinetics. Drug elimination. The variation of drug elimination rate according to the urinary ph 6. General pharmacodynamics. The variation of pharmacodynamic action according to various factors depending on the drug: dosage, drug association (interactions) 7. General pharmacodynamics. The variation of pharmacodynamic action in relation to various organismdepending factors: route of administration, species, reactivity Bibliografie / Bibliography 1. Cristea AN. Farmacologie generală. Bucureşti: Editura Didactică şi Pedagogică, Goodman & Gilman s. The Pharmacological Basis of Therapeutics. New York: McGraw-Hill, Med Div, Katzung BG. Basic and Clinical Pharmacology, Eleventh Edition. New York: McGraw-Hill, Med. Div., Pavelescu M, Hriscu A. Lucrări practice de farmacodinamie. Iaşi: Litografia IMF, Rang HP, Dale MM, Ritter JM, Flower RJ. Rang and Dale s Pharmacology, Sixth Edition. London: Churchill Livingstone Elsevier, The agreement between the course contents and the expectations of the representatives of the epistemic communities, professional associations and employers in the field related to the program The study program of the discipline is developed and revised periodically to meet the market dynamics of academic and professional qualifications, so as to ensure the formation of graduates who are capable of integrating into the labor market in health systems. Also, the study program contributes to the development of professional skills needed in the labor market. 10. Assessment Activity Assessment criteria Course Answers to exam / colloquium (final examination) Seminar / Practical lessons Final answers in the practical laboratory papers. Continuous testing during the semester (periodic testing by control works, essays, seminar activity) Assessment methods Descriptive written paper Descriptive written paper Oral and practical examination, descriptive written paper, MCQ testing Minimal standard of proficiency: Promotion with minimum grade Percentage of the final grade 50% 35% 15%
5 ED 50, LD 50 Therapeutic index The half-life Bioavailability Date: Signature of Coordinator for Teaching Activities Assoc. Prof. Veronica Bild, PhD Date of indorsement in the Council of the Department Signature of The Department Director Prof. Anca Miron, PhD
Universitatea de Medicină şi Farmacie Grigore T. Popa Iaşi Comisia pentru asigurarea calităţii DISCIPLINE RECORD/ COURSE / SEMINAR DESCRIPTION
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