Patronage requested A. ANICHINI (MILAN) M.P. COLOMBO (MILAN) V. BRONTE (VERONA) M. DEL VECCHIO (MILAN) M. DI NICOLA (MILAN) M.

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2 Patronage requested Faculty A. ANICHINI (MILAN) M.P. COLOMBO (MILAN) V. BRONTE (VERONA) M. DEL VECCHIO (MILAN) M. DI NICOLA (MILAN) M. FIGINI (MILAN) J. GALON (PARIS) G. KROEMER (PARIS) M. MAIO (SIENA) V. RUSSO (MILAN) 2 C. TRIPODO (PALERMO)

3 Presentation The 6th "Innovative therapy, monoclonal antibodies and beyond" Conference will convene a faculty of leading international experts to discuss new therapeutic opportunities emerging from two different areas of cancer pathology: aberrant cancer cell signaling and control of tumor growth by the immune system. The increasing knowledge of the molecular mechanisms responsible for neoplastic transformation, the biology of cancer cells, and the immunological mechanisms regulating tumor-host interaction, allowed us to identify and apply more effective anti-cancer biogical and immunological treatments. To date, the immuno-biotherapy is a continuously evolving treatment modality and it is currently integrated into the treatment algorythms of several different tumors. Furthermore, elucidating resistance mechanisms and exploiting cancer vulnerabilities to therapeutics will ultimately improve cancer therapy and patient care. In this context, metastatic melanoma represents a model in which several mechanisms of intrinsic and adaptive resistance were identified and different approaches have been testing in ongoing clinical trials. This Conference explores topics that will appeal to clinicians, as well as, basic, translational, and clinical scientists ranging from academics to industry. As in the past, the meeting will provide a highly interactive forum in which leading experts will discuss clinical and pre-clinical data, providing the audience with a broad overview of the most recent achievements in cancer biologic and immunologic therapy. Finally, several data support the combination of immunotherapies and standard treatments representing an intriguing challenge, and at the same time a real opportunity for the future therapeutic approaches. 3

4 Friday, 22 January 2016 WELCOME COFFEE Registration Welcome remarks of Authorities G. Apolone, Scientific Director of Fondazione IRCCS Istituto Nazionale dei Tumori (Milan) G. Galmozzi, Medical Director of Fondazione IRCCS Istituto Nazionale dei Tumori (Milan) Introduction M. Di Nicola (Milan) I SESSION: PRECLINICAL ASSAYES AND NOVEL BIOTARGETS Chairmen: J. Galon (Paris), M.P. Colombo (Milan) Mechanisms of immune evasion to check-point inhibitors V. Russo (Milan) Control of melanoma dedifferentiation program and immune escape by NFATc2 A. Anichini (Milan) Myeloid stroma and regulation of adaptive immunity in cancer V. Bronte (Verona) Overriding the inflammatory microenvironment C. Tripodo (Palermo) Immunoscore: a prognostic and predictive tool J. Galon (Paris) General discussion Keynote Lecture Tumor cell metabolism G. Kroemer (Paris) Introduced by: M.P. Colombo (Milan) BUFFET LUNCH

5 II SESSION: MONOCLONAL ANTIBODIES, CELL THERAPIES AND TK INHIBITORS Chairmen: M. Del Vecchio (Milan), M. Di Nicola (Milan) Hooking TRAIL-R2 to educate immune system to recognize cancer cells M. Figini (Milan) TVEC vaccination: rationale and immunological background M.P. Colombo (Milan) Overcoming resistance to targeted therapy M. Del Vecchio (Milan) Immune checkpoint blockade for the treatment of advanced cancer M. Maio (Siena) Discussion Conclusions M. Del Vecchio (Milan) CME Questionnaire compilation 5

6 General Informations 6 CONGRESS VENUE Aula A - Fondazione IRCCS Istituto Nazionale dei Tumori Via G. Venezian, 1 - MILAN SCIENTIFIC COMMITTEE Filippo de Braud Massimo Di Nicola Michele Del Vecchio Medical Oncology Department Fondazione IRCCS Istituto Nazionale dei Tumori Milan ORGANIZING SECRETARIAT Nadirex International Srl Via Riviera Pavia Tel /35 Fax info@nadirex.com OFFICIAL LANGUAGE English CME PROVIDER NR. 265 Nadirex International Srl CME The request for CME credits has been submitted to the Italian Ministry of Health.ID Nr CME credits: Nr. 7,5 The Congress is intended for the following figures: - Physician (Ematology, Infectious Diseases, Oncology, Internal Medicine, Transfusional Medicine) - Biologist - Nurse - Biomedical laboratory technician Participants: 100. In order to obtain CME credits, participants must: - Attend 100% of the sessions indicated in the programme - Fill in the personal data form, the form evaluating the event, and the learning questionnaire and give them to the Organizational Secretariat at the end of the Congress. The CME certificate will be sent by mail after the Congress to the address given on the personal data form. REGISTRATION The registration is free and includes: Partecipation in the conference work Congress Kit Certificate of Attendance CME credits Certificate Welcome coffee and lunch as scheduled REGISTRATION INSTRUCTIONS The Congress provides for a maximum of 100 participants. To register fill in and submit the registration form within January 20th, 2016 by fax to nr or online at The Organizing Secretariat will confirm the registration by .

7 Registration Form Fill in using capital letters and send to: NADIREX INTERNATIONAL s.r.l. Via Riviera, Pavia Fax info@nadirex.com - PLEASE COMPLETE THE FOLLOWING DETAILS PHISYCIAN BIOLOGIST NURSE BIOMEDICAL LABORATORY TECHNICIAN Name... Surname... Profession... Discipline... Specialized... Clinic/Institute... Division/Department... Address... Postal Code... Town/City... Province... Tel.... Fax... Mobile Tel I authorise the use of my personal data in accordance with Legislative Decree 196/2003 Date... Signature... 7

8 SI RINGRAZIANO LE SEGUENTI AZIENDE PER IL CONTRIBUTO NON CONDIZIONANTE: