Munich Cancer Registry

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1 Munich Cancer Registry Incidence and Mortality Selection Matrix Homepage Deutsch GIST: Gastroint. stromal tumor Survival Year of diagnosis Patients 837 Diseases 838 Cases evaluated 6 Creation date 9/22/16 Export date 8/17/16 Population 4.69 m BERLIN GERMANY BAVARIA MUNICH Munich Cancer Registry at Munich Cancer Center Marchioninistr. 15 Munich, Germany

2 GENERAL GIST: Gastroint. stromal tumor Page 2 of 12 Period of diagnosis % Relative survival N= Figure 1a. Relative survival of patients with gastroint. stromal tumor by period of diagnosis. Included in the evaluation are 65 cases diagnosed between 1998 and 14. The presented survival curves are derived from clinical records with valid follow-up informations, which means that death certificate cases (DCO) cases are omitted from the analysis. With this one restriction, the MCR has provided populationbased statistics since 1998, collecting data on all cancer cases in the region of southern Bavaria. Historical data of previous time periods can be heavily selected, therefore, univariate survival comparisons of the presented time periods must be carefully considered. Nonetheless, all calculable survival curves are depicted to facilitate the comparison of long time follow-up analyses of relative survival between particular cancers. Period of diagnosis n=172 n=433 obs. % rel. % obs. % rel. % Table 1b. Observed (obs.) and relative (rel.) survival of patients with gastroint. stromal tumor by period of diagnosis for period (N=65). Period of diagnosis n= % 7+ n= %

3 GENERAL GIST: Gastroint. stromal tumor Page 3 of 12 Gender % Survival N=65 Gender 9 8 Male n= % Female n= % Observed Expected Relative Figure 2a. Survival of patients with gastroint. stromal tumor by gender. Included in the evaluation are 65 cases diagnosed between 1998 and 14. Gender Male Female n=314 n=291 obs. % rel. % obs. % rel. % Table 2b. Observed (obs.) and relative (rel.) survival of patients with gastroint. stromal tumor by gender for period (N=65).

4 GENERAL GIST: Gastroint. stromal tumor Page 4 of 12 Gender % Conditional relative 2 / 5 year survival N=65 1 Gender 9 Male n= % Female n= % Conditional 2 year survival Conditional 5 year survival Time since diagnosis (years) Figure 2c. Conditional relative 2 / 5-year survival of patients with gastroint. stromal tumor by gender. For 65 of 65 cases diagnosed between 1998 and 14 valid data could be obtained for this item. Gender Male Female Cond. surv. % Cond. surv. % n 2 yrs 5 yrs n 2 yrs 5 yrs Table 2d. Conditional relative 2 / 5-year survival of patients with gastroint. stromal tumor by gender for period (N=65). Conditional relative survival rates refer to the relative survival probability, in this case for 2 and 5 years after cancer diagnosis, compared to the age- and sex-matched population (=%) under the condition of being alive for a certain time period (x-axis in Figure 2a). The results illustrate to what extent the cancer induced mortality of particular subgroups declines in the subsequent years after detection of the malignancy. For instance, according to the presented survival statistics, patients in the subgroup gender= Male, who are alive at least 3 years after cancer diagnosis, the conditional relative 2-year survival rate is 95.2% (n=172).

5 GENERAL GIST: Gastroint. stromal tumor Page 5 of 12 Age category % Relative survival N= Figure 3a. Relative survival of patients with gastroint. stromal tumor by age category. Included in the evaluation are 65 cases diagnosed between 1998 and 14. Age category -49 yrs 5-59 yrs 6-69 yrs 7+ yrs n=88 n=111 n=181 n=225 obs. % rel. % obs. % rel. % obs. % rel. % obs. % rel. % Table 3b. Observed (obs.) and relative (rel.) survival of patients with gastroint. stromal tumor by age category for period (N=65). Age category -49 yrs n= % 5-59 yrs n= % 6-69 yrs n= % 7+ yrs n= %

6 GENERAL GIST: Gastroint. stromal tumor Page 6 of 12 Histology % Relative survival N= Figure 4a. Relative survival of patients with gastroint. stromal tumor by histology. For 63 of 65 cases diagnosed between 1998 and 14 valid data could be obtained for this item. Subgroups with sample size <15 are dropped from the chart. Histology GI stromal tumor, NOS GI stromal sarcoma n=7 n=596 obs. % rel. % obs. % rel. % Table 4b. Observed (obs.) and relative (rel.) survival of patients with gastroint. stromal tumor by histology for period (N=63). Histology GI stromal tumor, NOS n=7 1.2% GI stromal sarcoma n= %

7 GENERAL GIST: Gastroint. stromal tumor Page 7 of 12 Extent of disease % Relative survival N= Figure 4c. Relative survival of patients with gastroint. stromal tumor by extent of disease. For 322 of 65 cases diagnosed between 1998 and 14 valid data could be obtained for this item. For a total of 3 cases an evaluable classification was established. The grey line represents the subgroup of 2 patients with missing values regarding extent of disease (49.9% of 65 patients, the percent values of all other categories are related to n=3). Subgroups with sample size <15 are dropped from the chart. Extent of disease Local Regional Distant NA/NOS n=217 n=9 n=77 n=2 obs. % rel. % obs. % rel. % obs. % rel. % obs. % rel. % Table 4d. Observed (obs.) and relative (rel.) survival of patients with gastroint. stromal tumor by extent of disease for period (N=3). Extent of disease Local n= % Regional n=9 3.% Distant n= % NA/NOS n=2 99.7%

8 PROGRESSION GIST: Gastroint. stromal tumor Page 8 of 12 % Time to first progression (TTP) N= Type of progression Any type (CI) Events=99 Any type (1-KM) Events= Figure 5a. Time to first progression of 526 patients with gastroint. stromal tumor diagnosed between 1998 and 14 (M only in solid cancers) estimated by cumulative incidence function (CI, solid line) accounting for death as competing risk and by inverse Kaplan-Meier estimate (1-KM, dashed line). The frequency of events may be underestimated due to underreporting. Type of progression Any type (CI) Any type (1-KM) n=526 n=526 % % Table 5b. Time to first progression of patients with gastroint. stromal tumor for period (N=526).

9 PROGRESSION GIST: Gastroint. stromal tumor Page 9 of 12 Progression type % Observed post-progression survival N= Figure 5c. Observed post-progression survival of 145 patients with gastroint. stromal tumor diagnosed between 1998 and 14. These 145 patients with documented progression events during their course of disease represent 24.1 % of the totally 62 evaluated cases (incl. M1, n=76, 12.6 %). Patients with cancer relapse documented via death certificates only were excluded (n=, 5. %). Medical record documentation often lacks the linguistic severity to distinguish between local relapse, regional lymph node metastasis and distant spread in solid cancers. Frequently, the statement not specified is the only information in registries regarding relapse of the disease. The category Any type denotes all cases who suffered from at least one relapse during the course of disease (incl. primary M1-status). Although, the real number of relapsed patients is likely to be much higher. The accumulated percentage of patients with local relapse or distant metastasis exceeds the % value because patients are potientially considered in more than one subgroup. Type of progression Any type n=145 % Table 5d. Observed post-progression survival of patients with gastroint. stromal tumor for period (N=145). Type of progression Any type n=145.%

10 PROGRESSION GIST: Gastroint. stromal tumor Page of 12 Type of Progression: Distant metastasis % Observed post-progression survival by period of progression date N= Figure 5e. Observed post-progression (distant metastasis) survival of 124 patients with gastroint. stromal tumor diagnosed between 1998 and 14 by period of progression. Period of progression n=56 n=68 % % Table 5f. Observed post-progression (distant metastasis) survival of patients with gastroint. stromal tumor for period by period of progression (N=124). Period of progression n= % 7+ n= %

11 USAGE GIST: Gastroint. stromal tumor Page 11 of 12 Shortcuts MCR Munich Cancer Registry, Germany NCI National Cancer Institute, USA SEER Surveillance, Epidemiology, and End Results, USA UICC Union for International Cancer Control, Geneva DCO Death certificate only Death certificate provides the only notification to the registry. NA Not available NOS Not otherwise specified OS Overall/Observed survival Overall/Observed survival (Kaplan-Meier estimate) Date of entry: diagnosis Event: death from any cause RS Relative survival Survival compared to general population, ratio of observed to expected survival (Ederer II method), reflecting cancer specific survival AS Assembled survival Assembled chart of observed, expected, relative survival CS Conditional survival Survival probability under the condition of surviving a given period of time TTP Time to progression Time to first progression / relapse Date of entry: diagnosis Event: (progression / relapse): first local-, lymph node recurrence, distant metastasis or unspecified progression PPS 1-KM CI 1 minus Kaplan-Meier estimator ( inverse Kaplan-Meier estimator) Cumulative incidence Death as competing risk (according to Kalbfleisch und Prentice) Post-progression survival Survival since first progression / relapse (Kaplan-Meier estimate) Date of entry (progression / relapse): first local-, lymph node recurrence, distant metastasis or unspecified progression Event: death from any cause Recommended Citation Munich Cancer Registry. Survival GIST: Gastroint. stromal tumor [Internet]. 16 [updated 16 Sep 22; cited 16 Nov 1]. Available from: Gastroint.-stromal-tumor-survival.pdf Copyright The content of the public web site provided by the Munich Cancer Registry is available worldwide and free of charge. All documents are free to download, utilize, copy, print-out and distribute, providing that the MCR is referenced. Disclaimer The Munich Cancer Registry reserves the right to not be responsible for the topicality, correctness, completeness or quality of the information provided. Liability claims regarding damage caused by the use of any information provided, including any kind of information which is incomplete or incorrect, will therefore be rejected.

12 INDEX GIST: Gastroint. stromal tumor Page 12 of 12 Fig./Tbl. Index of figures and tables Page 1a Relative survival by period of diagnosis (chart) 2 1b Survival by period of diagnosis (table) 2 2a Survival by gender (chart) 3 2b Survival by gender (table) 3 2c Conditional survival by gender (chart) 4 2d Conditional survival by gender (table) 4 3a Relative survival by age category (chart) 5 3b Survival by age category (table) 5 4a Relative survival by histology (chart) 6 4b Survival by histology (table) 6 4c Relative survival by extent of disease (chart) 7 4d Survival by extent of disease (table) 7 5a Time to first progression (chart) 8 5b Time to first progression (table) 8 5c Observed post-progression survival (chart) 9 5d Observed post-progression survival (table) 9 5e Observed post-progression survival by period of progression (chart) 5f Observed post-progression survival by period of progression (table)