California Prenatal Screening Program
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1 California Prenatal Screening Program Kaiser Permanente Genetic Screening Services Presented by: Carlyne Ludington, MS, CGC Genetic Counselor, Genetics Department Baldwin Park Medical Center Time to Change The Expanded AFP Screening Program will become the California Prenatal Screening Program (CPSP) Will expand to include screening in the first trimester Now an integrated screening approach Starting on March 12,
2 What Will Change? Currently, 1 st trimester specimens are sent to Quest, and 2 nd trimester specimens are sent to the State-funded Newborn and Prenatal Screening (NAPS) lab at Kaiser. Beginning 3/12/09, ALL maternal serum screening specimens will be analyzed at the Kaiser NAPS lab. New 1 st and 2 nd trimester lab forms from the State Prenatal Screening: State Regulations All pregnant women must be offered participation in California s maternal serum screening program. Patients have the right to decline screening. As of 4/1/09, no lab, business, or program can perform prenatal screening for chromosome abnormalities and neural tube defects other than the CA Prenatal Screening Program administered by the CA Dept. of Public Health. Kaiser pays the State $162 per patient. It is a onetime fee which covers either one or two blood specimen results plus genetic counseling and diagnostic services (ultrasound, CVS, amniocentesis) if the result is Screen Positive. 2
3 Which Conditions Does CPSP Screen For? Continues to screen for the same four genetic conditions/birth defects: Down syndrome Trisomy 18 Neural tube defects/abdominal wall defects Smith-Lemli-Opitz syndrome If patient considering diagnostic testing (CVS/amnio), refer to Genetics CPSP Offers 3 Types of Screening Tests Quad marker screening One blood draw at weeks Serum integrated screening Combines 1 st trimester blood test results with 2 nd trimester blood test results Full integrated screening Combines nuchal translucency (NT) results with 1 st and 2 nd trimester blood test results Preliminary risk assessment available in 1 st trimester 3
4 CA Prenatal Screening Program 1 st trimester specimen drawn 10w0d-13w6d *Down syndrome detection rates No NT NT obtained 11w2d-14w2d NO 1 st T Risk Assessment 1 st T Risk Assessment 2 nd T specimen drawn (no 1 st T specimen) 2 nd T specimen NOT drawn 2 nd T specimen Drawn 15w0d-20w0d 2 nd T specimen NOT drawn 2 nd T specimen drawn No NT NT data added NO Risk Assessment Serum Integrated Screening (85%)* 1st T Risk Assessment (75%)* Full Integrated Screening (90%)* Quad Screening (80%)* Quad + NT Screening (89%)* Timing 1 st Trimester Blood Draw: 10w0d 13w6d Nuchal Translucency (NT): 11w2d 14w2d (CRL 45mm-84mm) 2 nd Trimester Blood Draw: 15w0d 20w0d 4
5 Program Analytes 1 st trimester: PAPP-A (pregnancy associated plasma protein A) hcg (human chorionic gonadotropin) Nuchal Translucency (NT) if available 2 nd trimester: AFP (alpha-fetoprotein) hcg (human chorionic gonadotropin) ue3 (unconjugated estriol) INH (inhibin) Nuchal Translucency (NT) Ultrasound measurement of fluid-filled space at the back of the fetal neck Increased NT is associated with increased risk for chromosome abnormalities, heart defects, and other birth defects Must be done by certified NT practitioner approved by the CA Prenatal Screening Program Cost is not reimbursed by the State 5
6 Nuchal Translucency (NT) 1 mm 3 mm Quad Marker Screening Blood draw at 15w0d-20w0d. Should be offered to: Women who did not have a 1 st trimester blood specimen sent to the State Women who had CVS risk assessment for NTD/SLOS only Quad + NT Screening: Can provide a 1 st trimester NT to obtain a higher detection rate for Down syndrome and Trisomy 18. Results: Screen Negative Screen Positive Patient referred to Genetics by PNS Coordinator. State will cover cost of genetic counseling, ultrasound, and amnio. 6
7 Serum Integrated Screening (No NT) 1ST TRIMESTER: Blood draw: 10w0d-13w6d State sends OB provider and patient an acknowledgement letter after receiving 1 st trimester blood specimen. No preliminary results provided. 2ND TRIMESTER: Blood draw: 15w0d-20w0d Results provided after 2 nd trimester blood draw. Screen Negative Screen Positive Patient referred to Genetics by PNS Coordinator. State will cover cost of genetic counseling, ultrasound, and amnio. Full Integrated Screening FIRST TRIMESTER: Blood draw: 10w0d-13w6d NT: 11w2d-14w2d First Trimester Screening Results: Preliminary Risk Assessment (Screen Negative) Draw 2 nd trimester specimen for full integrated result Screen Positive Patient referred to Genetics by PNS Coordinator Preliminary result identifies patients at highest risk 7
8 Options for Patients with Positive FTS Results Refer patient to Genetics for follow-up Genetic Counseling Patient declines follow-up services CVS (1 st trimester) Amnio and US (15-20 w) Patient elects combined risk assessment Patient elects combined risk assessment Patient declines combined risk assessment Obtain 2 nd trimester specimen (for NTD/SLOS risk assessment) Obtain 2 nd trimester specimen Obtain 2 nd trimester specimen Full Integrated Screening (cont.) SECOND TRIMESTER: Blood draw: 15w0d-20w0d Full Integrated Screening Results: Screen Negative Screen Positive Patient referred to Genetics by PNS Coordinator. State will cover cost of genetic counseling, ultrasound, and amnio. 8
9 Special Circumstances: Multiple Gestation Twin pregnancies can have quad, serum integrated, or full integrated screening. Quad Quad + NT Serum Integrated Full Integrated 1 st Trimester: Preliminary Risk T21, NTD T21, T18, NTD T21, NTD T21, T18, NTD T21, T18 Serum screening is not available for pregnancies with 3 or more fetuses. Offer NT only. Special Circumstances: Fetal Demise or Reduction Fetal Demise 8w0d Fetal Demise >8w0d 1 st Trimester Specimen Do NOT draw specimen NOT Screenable 2 nd Trimester Specimen Screenable* (quad only) NOT Screenable Fetal Reduction (Anytime During Pregnancy) NOT Screenable NOT Screenable *Write down number of VIABLE fetuses on lab form. 9
10 Integrated Screening in Kaiser Permanente What is the process? 1 st Trimester Blood Draw Order 1st blood draw in Health Connect: 1ST TRIMESTER SCREEN, CALIFORNIA (PAPP-A, HCG) insert order code here If 2 nd trimester draw also being ordered, place as future order (expected = 16 weeks GA) Complete State 1 st trimester lab form BLUE border Peel off label from 1 st trimester lab form and place on 2 nd trimester lab form Document 1 st trimester form number in HealthConnect Optional: Contact first trimester screening (FTS) case manager to arrange NT appointment 10
11 2 nd Trimester Blood Draw Order 2nd blood draw in HealthConnect: 2ND TRIMESTER SCREEN, CALIFORNIA (AFP, HCG, UE3, INHIBIN) Insert order code here Complete State 2nd trimester lab form GREEN border Make sure label from 1 st trimester lab form is placed on 2 nd trimester lab form If label is not available, write in the 1 st trimester form number CA Prenatal Screening Consent Form 11
12 1 st Trimester Lab Form 2 nd Trimester Lab Form 12
13 Nuchal Translucency (NT) Information Complete this section if the patient already had NT NT practitioner credential number is required Provide NT and CRL measurements in mm For twin pregnancies: Complete CRL and NT measurements for each twin Indicate chorionicity Pregnancy Dating Complete only ONE dating method US dating is preferred Use BPD or CRL (do not use average, FL, or AC) Use decimal OR weeks + days (not both) Only use LMP if US dating is not available Never use physical exam Do not use LMP for twin pregnancies 13
14 CVS Question on 2 nd Trimester Form Mark yes ONLY if the patient had CVS with fetal karyotype If marked yes, patient will receive NTD/SCD only screening Question Regarding Research If the patient declines the use of her specimen for research on the consent form, fill in the appropriate box on the lab forms. First Trimester Form Question 13 Second Trimester Form Question 15 14
15 First Trimester Specimen Label Label is on PINK page of 1 st trimester form 15
16 Genetic Screening Services Prenatal Screening (PNS) Coordinators: Caleen A. Danon, MS Aki Logg, MS, CGC Amy Liou, MS, CGC Prenatal Screening Support Staff: Rachiel Reyes John Criscione Phone: (626) Tie Line: Prenatal Screening Case Manager Contact List Medical Center Baldwin Park Bellflower South Bay Los Angeles West LA Riverside Fontana Anaheim/OC San Diego Panorama City Woodland Hills Kern County Case Manager Stacy Perez Shirley Rone Shirley Rone Traci Richardson Traci Richardson Cindy Williams Tyra Blount Vickylynn Rubio Laura Diaz Araceli Rodriguez Araceli Rodriguez Sonia Dhillon Phone number Tie line
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