Supplementation of culture media. multiple unsuccessful IVF attempts: a new indication for EmbryoGen?

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Supplementation of culture media. multiple unsuccessful IVF attempts: a new indication for EmbryoGen?"

Transcription

1 Supplementation of culture media with GM-CSF in patients with multiple unsuccessful IVF attempts: a new indication for EmbryoGen? Ioannis Sfontouris, M.Med.Sci., PhD Head of Embryology, Eugonia Assisted Reproduction Unit

2 GM-CSF In humans Promotes morula and blastocyst formation Reduces ICM apoptosis Appears to be beneficial for pregnancy outcome No effect on chromosomal constitution Reduced GM-CSF blood concentrations in women with recurrent miscarriage

3 GM-CSF Commercially available culture medium containing 2 ng/ml rhgm-csf (Embryogen, Origio) Proposed indication for use: Previous miscarriage

4 Ziebe et al. 2013, Large RCT, n=1332 Significant improvement in PRs and IRs using GM-CSF. More pronounced effect in patients with previous miscarriage

5 Systematic review, (Siristatidis et al. 2013): 6 studies Similar implantation and pregnancy rates in general IVF population using GMCSF-supplemented media

6 Other potential indications for Embryogen Multiple failed IVF attempts / RIF? Testicular biopsy cases? Other?

7 Study question Is the inclusion of GM-CSF in embryo culture media (Embryogen) associated with increased clinical pregnancy rates in patients with multiple unsuccessful IVF attempts?

8 Sfontouris et al, ESHRE 2013 Preliminary data 79 patients (n=37 Embryogen versus n=42 Control) Similar pregnancy and implantation rates

9 Study design Prospective observational study patients Inclusion criteria: Patients undergoing fresh IVF cycle At least 2 previous failed IVF attempts (without establishment of clinical pregnancy at week 7) Exclusion criteria: Women >45 years Egg donation Testicular biopsy Frozen oocyte/embryo cycles

10 Methodology Control group N=80 Ovarian stimulation OPU 36hrs following hcg Embryogen group N= 64 Insemination in Universal-IVF Post-ICSI & Embryo culture in ISM1 Embryo transfer on Day 2/3 in UTM (n=67) Insemination in Embryogen Post-ICSI & Embryo culture in Embryogen Embryo transfer on Day 2/3 in Embryogen (n=58)

11 Patient characteristics EmbryoGen N=64 Control N=80 Age (years) 37.9± ±3.3 BMI (kg/m 2 ) 23.6± ±4.2 Number of previous 4.3± ±3.4 IVF attempts Baseline FSH (IU/l) 9.9± ±7.3 AFC 5.9± ±5.9 Number of follicles on day of hcg Oestradiol on day of hcg (pg/ml) Progesterone on day of hcg (ng/ml) 10.8± ± ± ± ± ±0.4 No statistical significance

12 Embryological data EmbryoGen N=64 Control N=80 Number of oocytes 8.2± ±9.4 retrieved Mature oocytes (in 4.0± ±6.1 ICSI patients) Number of 2PN 4.7± ±5.7 Number of good morphology embryos Number of embryos transferred Number of embryos cryopreserved 2.6± ± ± ± ± ±2.6 No statistical significance

13 Pregnancy data Overall population EmbryoGen Control N o patients N o patients undergoing ET Positive test n(%) per 30 (51.7) 33 (49.3) ET Clinical pregnancy 22 (37.9) 30 (44.8) n(%) per ET Ongoing pregnancy 17 (29.3) 24 (35.8) n(%) per ET Implantation rate (%) 35/135 (25.9) 44/149 (29.5) Ongoing IR (%) 30/135 (22.2) 41/149 (27.5) Preclinical miscarriage n(%) Clinical miscarriage n(%) 8 (26.7) 4 (12.1) 5 (22.7) 6 (20) No statistical significance

14 % ,7 49,3 44,8 Embryogen Control 40 37,9 35,8 No statistical significance ,3 29,5 25,9 26,7 22, ,1 10 0

15 Pregnancy data by age 39 years >39 years EmbryoGe n Control EmbryoGen Control N o patients N o patients undergoing ET Positive test per ET 22 (64.7) 25 8 (33.3) 8 (28.6) n(%) (64.1) Clinical pregnancy 18 (52.9) 23 4 (16.7) 7 (25.0) per ET n(%) (59.0) Ongoing pregnancy 14 (41.2) 19 3 (12.5) 5 (17.9) per ET n(%) (48.7) Implantation rate (IR) 29/85 (31.1) 37/90 (41.1) 6/50 (12) 7/59 (11.9) Ongoing IR 25/85 (29.4) 34/90 (37.8) 5/50 (10) 7/59 (11.9) No statistical significance

16 Conclusions Similar PRs and IRs in Embryogen and controls Differences non-statistically significant GM-CSF does not appear to be beneficial in patients with previous failed IVF attempts Number of patients in present study not high enough to obtain statistical significance Sample size calculation for 80% power based on present data: 1570 patients (785 patients per group)

17 Ideally in combination with array-cgh: Exclude Conclusions GM-CSF promising growth factor Limited data regarding effect of GM-CSF on human embryos and pregnancy outcome Technical limitation: ET on Day 2 or 3 only Issue of high chromosome abnormalities: Only 35% of embryos were euploid in patients with idiopathic recurrent pregnancy loss (Hodes-Wertz et al. 2012, Fertil Steril) Larger studies with adequate power and follow-up of children born are required to verify beneficial effect of GM-CSF

18 Thanks to Origio and Life Science Chemilab for subsidy of Embryogen

Assisted Reproductive Technologies at IGO

Assisted Reproductive Technologies at IGO 9339 Genesee Avenue, Suite 220 San Diego, CA 92121 858 455 7520 Assisted Reproductive Technologies at IGO Although IGO no longer operates an IVF laboratory or program as such, we work closely with area

More information

Community Hospital North. Clearvista Dr.

Community Hospital North. Clearvista Dr. 100% IVF Refund Program Community Hospital North Clearvista Dr. N Dr. David Carnovale and Dr. Jeffrey Boldt, along with everyone at Community Reproductive Endocrinology, are committed to providing you

More information

In - Vitro Fertilization Handbook

In - Vitro Fertilization Handbook In - Vitro Fertilization Handbook William F. Ziegler, D.O. Medical Director Scott Kratka, ELD, TS Embryology Laboratory Director Lauren F. Lucas, P.A.-C, M.S. Physician Assistant Frances Cerniak, R.N.

More information

Present and future role of PGS according to different clinical indications Anna Pia Ferraretti, Cristina Magli, Luca Gianaroli SISMER- Bologna - Italy

Present and future role of PGS according to different clinical indications Anna Pia Ferraretti, Cristina Magli, Luca Gianaroli SISMER- Bologna - Italy PCC 1: Clinical aspects of PGD/PGS Present and future role of PGS according to different clinical indications Anna Pia Ferraretti, Cristina Magli, Luca Gianaroli SISMER- Bologna - Italy Classical indications

More information

IN VITRO FERTILISATION (IVF) & INTRACYTOPLASMIC SPERM INJECTION (ICSI) INCLUDING FREEZING OF EMBRYOS CONSENT FORM

IN VITRO FERTILISATION (IVF) & INTRACYTOPLASMIC SPERM INJECTION (ICSI) INCLUDING FREEZING OF EMBRYOS CONSENT FORM IN VITRO FERTILISATION (IVF) & INTRACYTOPLASMIC SPERM INJECTION (ICSI) INCLUDING FREEZING OF EMBRYOS CONSENT FORM Patient Name... DOB... Partner Name (if applicable)...dob... Patient Number... I/ We request

More information

Clinical Policy Committee

Clinical Policy Committee Northern, Eastern and Western Devon Clinical Commissioning Group South Devon and Torbay Clinical Commissioning Group Clinical Policy Committee Commissioning policy: Assisted Conception Fertility assessment

More information

Assisted Reproduction: In Vitro Fertilization, Intracytoplasmic Sperm Injection, Assisted Hatching, and Embryo Cryopreservation/Disposition Consent

Assisted Reproduction: In Vitro Fertilization, Intracytoplasmic Sperm Injection, Assisted Hatching, and Embryo Cryopreservation/Disposition Consent Assisted Reproduction: In Vitro Fertilization, Intracytoplasmic Sperm Injection, Assisted Hatching, and Embryo Cryopreservation/Disposition Consent Book Number Patient Name (Please print): Patient, IVFNE

More information

Assisted Reproduction: In Vitro Fertilization, Intracytoplasmic Sperm Injection, Assisted Hatching, and Embryo Cryopreservation/Disposition Consent

Assisted Reproduction: In Vitro Fertilization, Intracytoplasmic Sperm Injection, Assisted Hatching, and Embryo Cryopreservation/Disposition Consent Assisted Reproduction: In Vitro Fertilization, Intracytoplasmic Sperm Injection, Assisted Hatching, and Embryo Cryopreservation/Disposition Consent Book Number Patient Name (Please print): Patient, IVFNE

More information

Symposium on RECENT ADVANCES IN ASSISTED REPRODUCTIVE TECHNOLOGY

Symposium on RECENT ADVANCES IN ASSISTED REPRODUCTIVE TECHNOLOGY Symposium on RECENT ADVANCES IN ASSISTED REPRODUCTIVE TECHNOLOGY Dr Niel Senewirathne Senior Consultant of Obstetrician & Gynaecologist De zoyza Maternity Hospita 1 ART - IVF & ICSI 2 Infertility No pregnancy

More information

Figure 1 shows the number of institutions and countries of the 155 reporting clinics to RLA. It also describes the type of procedures performed in

Figure 1 shows the number of institutions and countries of the 155 reporting clinics to RLA. It also describes the type of procedures performed in 1 Figure 1 shows the number of institutions and countries of the 155 reporting clinics to RLA. It also describes the type of procedures performed in the 47326 cycles, which include 31857 initiated cycles

More information

Overview for IVF Patients Introduction

Overview for IVF Patients Introduction 810 Chafee Avenue Augusta, GA 30904 Phone: 706-722-4434 Fax: 706-722-9647 Overview for IVF Patients Introduction 618 Ponder Place Evans, GA 30809 Phone: 706-722-4434 Fax: 706-722-9647 In vitro fertilization

More information

European IVF Monitoring (EIM) Year: 2008

European IVF Monitoring (EIM) Year: 2008 European IVF Monitoring (EIM) Year: 2008 Name of country POLAND Name and full address of contact person. professor Rafal Kurzawa MD PhD Fertility and Sterility Special Interest Group Polish Gynaecological

More information

ASSISTED REPRODUCTIVE TECHNOLOGIES (ART)

ASSISTED REPRODUCTIVE TECHNOLOGIES (ART) ASSISTED REPRODUCTIVE TECHNOLOGIES (ART) Dr. Herve Lucas, MD, PhD, Biologist, Andrologist Dr. Taher Elbarbary, MD Gynecologist-Obstetrician Definitions of Assisted Reproductive Technologies Techniques

More information

Delivering excellence, realising dreams. Price list

Delivering excellence, realising dreams. Price list Delivering excellence, realising dreams Price list Consultations & Assessments Procedure/investigation Consultation with Consultant - (IVF Initial Consultation includes trans-vaginal scan) 180.00 Follow-up

More information

Consultations & other investigations

Consultations & other investigations Pricelist Please note as part of pre-treatment consultations, you may be required to have blood tests performed, the costs of which are not included in the treatment cycles. These costs are outlined below.

More information

IVF MONEY-BACK PLAN IN PARTNERSHIP WITH

IVF MONEY-BACK PLAN IN PARTNERSHIP WITH IVF MONEY-BACK PLAN IN PARTNERSHIP WITH Programmes Refund Programme Up to 3 fresh cycles of IVF/ICSI and all frozen embryo transfers Available to women under 40 years old Medical Review required for all

More information

Empowering accurate genetic answers for IVF clinics. Preimplantation Genetic Screening (PGS) and Preimplantation Genetic Diagnosis (PGD) solutions.

Empowering accurate genetic answers for IVF clinics. Preimplantation Genetic Screening (PGS) and Preimplantation Genetic Diagnosis (PGD) solutions. Empowering accurate genetic answers for IVF clinics. Preimplantation Genetic Screening (PGS) and Preimplantation Genetic Diagnosis (PGD) solutions. Uncovering answers for informed choices. Illumina is

More information

Topic: Male Factor Infertility

Topic: Male Factor Infertility Topic: Male Factor Infertility Topic Overview: Male Factor Infertility Comparisons of pregnancy rates at insemination based on total motile sperm counts from the 1999 and 21 World Health Organization (WHO)

More information

How to evaluate success with PGS

How to evaluate success with PGS How to evaluate success with PGS Don Leigh ASPIRE April 2014 IVF... What can be done to improve things? ~2/3 of clinical miscarriages are caused by chromosome aneuploidy Some aneuploidies are not observed

More information

Patient information Pre-implantation genetic screening (PGS)

Patient information Pre-implantation genetic screening (PGS) Page 1 of 5 Patient information Pre-implantation genetic screening (PGS) SUMMARY Pre-implantation genetic screening (PGS) analyses the genetic constitution of an egg or embryo to determine whether the

More information

Tower Hamlets CCG Fertility policy

Tower Hamlets CCG Fertility policy Tower Hamlets CCG Fertility policy Approved December 2014 Introduction Tower Hamlets CCG is responsible for commissioning a range of health services including hospital, mental health and community services

More information

Guide to IVF Laboratory Results

Guide to IVF Laboratory Results Guide to IVF Laboratory Results PACIFIC CENTRE FOR REPRODUCTIVE MEDICINE 500-4601 Canada Way, Burnaby BC V5G 4X7 LAB-416-20140122-1 The following information will guide you through what results to expect

More information

Preimplantation genetic screening (PGS)

Preimplantation genetic screening (PGS) Preimplantation genetic screening (PGS) Dagan Wells Reprogenetics UK In vitro fertilization (IVF) A highly successful medical intervention Infertility treatment revolutionized Estimated that >5 million

More information

NICE Pathways bring together all NICE guidance, quality standards and other NICE information on a specific topic.

NICE Pathways bring together all NICE guidance, quality standards and other NICE information on a specific topic. In vitro fertilisation treatment for people with fertility problems bring together all NICE guidance, quality standards and other NICE information on a specific topic. are interactive and designed to be

More information

East and North Hertfordshire CCG Fertility treatment and referral criteria for tertiary level assisted conception. December 2014

East and North Hertfordshire CCG Fertility treatment and referral criteria for tertiary level assisted conception. December 2014 East and North Hertfordshire CCG Fertility treatment and referral criteria for tertiary level assisted conception December 2014 1 1. Introduction This policy sets out the entitlement and service that will

More information

London Fertility Centre Price List

London Fertility Centre Price List London Fertility Centre Price List Fertility Testing Packages Standard Female fertility testing package AMH Ultrasound scan 15 minute doctor consultation to discuss your results Premium Female fertility

More information

Information Sheet. Fertility in the older Woman

Information Sheet. Fertility in the older Woman Infertility National Public Awareness Campaign Information Sheet Fertility in the older Woman Changes in egg number and quality with age: It may be surprising to learn that all the eggs a woman ever produces

More information

The relevant NICE Clinical Guidance 156, Fertility can be accessed here: http://www.nice.org.uk/guidance/cg156

The relevant NICE Clinical Guidance 156, Fertility can be accessed here: http://www.nice.org.uk/guidance/cg156 City and Hackney CCG Fertility policy Approved January 2015 Introduction City and Hackney CCG is responsible for commissioning a range of health services including hospital, mental health and community

More information

The relevant NICE Clinical Guidance 156, Fertility can be accessed here:

The relevant NICE Clinical Guidance 156, Fertility can be accessed here: Islington CCG Fertility Policy Approved 29 January 2015 Introduction Islington CCG is responsible for commissioning a range of health services including hospital, mental health and community services for

More information

The relevant NICE Clinical Guidance 156, Fertility can be accessed here:

The relevant NICE Clinical Guidance 156, Fertility can be accessed here: Newham CCG Clinical Fertility policy. September 2015 This policy has been developed following consultation with local GPs and with lead clinicians at the fertility units at Bartshealth and the Homerton.

More information

SELECTCCS. Your guide to aneuploidy screening

SELECTCCS. Your guide to aneuploidy screening SELECTCCS Your guide to aneuploidy screening GROWING FAMILIES What is SelectCCS? Available only through the Foundation for Embryonic Competence (FEC), SelectCCS is the most well-validated and proven method

More information

SUCCESS RATES OF IVF CYCLES IN SANATORIUM HELIOS,

SUCCESS RATES OF IVF CYCLES IN SANATORIUM HELIOS, - 1 - First we would like to explain how we calculate our results. To understand whether they are objective and true, we would like to clarify our philosophy and practices. What we do is based upon long-term

More information

Clinical Reference Group Quality & Safety Committee Governing Body. Policy Screened

Clinical Reference Group Quality & Safety Committee Governing Body. Policy Screened Fertility Policy 1 SUMMARY This policy is intended to support individuals and couples who want to become parents but who have a possible pathological problem (physical or psychological) leading to them

More information

ASSISTED REPRODUCTIVE TECHNOLOGY (ART)

ASSISTED REPRODUCTIVE TECHNOLOGY (ART) ASSISTED REPRODUCTIVE TECHNOLOGY (ART) Welcome to DFW Fertility Associates/ Presbyterian Hospital ARTS program. This document provides an overview of treatment protocols and more specific instructions

More information

Vitrification: Choosing which blastocysts to vitrify. Joe Conaghan PhD Pacific Fertility Center San Francisco

Vitrification: Choosing which blastocysts to vitrify. Joe Conaghan PhD Pacific Fertility Center San Francisco Vitrification: Choosing which blastocysts to vitrify Joe Conaghan PhD Pacific Fertility Center San Francisco Las Vegas, ABB Mtg, May 17 th 2013 Blastocyst vitrification introduced 2007 800+ retrievals

More information

European IVF Monitoring (EIM) Year: 2010

European IVF Monitoring (EIM) Year: 2010 European IVF Monitoring (EIM) Year: 2010 Name of country: Poland Name and full address of contact person: Professor Rafal Kurzawa, MD PhD Fertility and Sterility Special Interest Group Polish Gynaecological

More information

AGE & FERTILITY: Effective Evaluation & Treatment I. LANE WONG, MD, FACOG. www.hopefertilitycenter.com www.hopeivf.com

AGE & FERTILITY: Effective Evaluation & Treatment I. LANE WONG, MD, FACOG. www.hopefertilitycenter.com www.hopeivf.com Page 1 of 6 AGE & FERTILITY: Effective Evaluation & Treatment I. LANE WONG, MD, FACOG. www.hopefertilitycenter.com www.hopeivf.com Age has a profound effect on female fertility. This is common knowledge,

More information

The Olive BRA NCH Fertility unit PATIENT INFORMATION SERIES

The Olive BRA NCH Fertility unit PATIENT INFORMATION SERIES The Olive BRA NCH Fertility unit PATIENT INFORMATION SERIES What you need to know about IVF/ICSI- ET? The following information explains briefly the procedures of In Vitro Fertilisation (IVF/ICSI). This

More information

PRICE LIST OF THE CLINIC OF REPRODUCTIVE MEDICINE AND GYNAECOLOGY IN ZLIN This price list is valid from

PRICE LIST OF THE CLINIC OF REPRODUCTIVE MEDICINE AND GYNAECOLOGY IN ZLIN This price list is valid from PRICE LIST OF THE CLINIC OF REPRODUCTIVE MEDICINE AND GYNAECOLOGY IN ZLIN This price list is valid from 6. 4. 2016 All costs for treatment do not include the cost of medication. The full payment for the

More information

Counselling Session for IVF/ET patients

Counselling Session for IVF/ET patients Page Page 1 of 9 Counselling Session for IVF/ET patients 1. Please attend the following counselling session. Place: Seminar Room, Room 509, 5/F, Block K, Queen Mary Hospital Lecture Theatre, Room 602,

More information

Regional Fertility Centre

Regional Fertility Centre Regional Fertility Centre Patient Information In-Vitro Fertilisation (IVF& ICSI) Page 1 of 7 Contents 1.0 IVF& ICSI 2.0 Early Embryo Viability Assessment (EEVA) 3.0 Problems that can occur during treatment

More information

NON MEDICARE FEES CANBERRA FERTILITY CENTRE VERSION JANUARY 2015 AM QWB 295

NON MEDICARE FEES CANBERRA FERTILITY CENTRE VERSION JANUARY 2015 AM QWB 295 NON MEDICARE FEES CANBERRA FERTILITY CENTRE VERSION JANUARY 2015 AM QWB 295 1 CANBERRA FERTILITY CENTRE Suite 9, Level 2, Peter Yorke Building, Calvary John James Hospital, 173 Strickland Crescent, DEAKIN

More information

OUR IVF/ICSI PROGRAMME

OUR IVF/ICSI PROGRAMME OUR IVF/ICSI PROGRAMME The Manzanera Fertility Clinic has designed a simple fertility programme that aims to be convenient for couples living outside of Spain while maximising your chances of success.

More information

Setting new standards in IVF

Setting new standards in IVF Setting new standards in IVF The clinical challenge Embryo aneuploidy is known to increase with maternal age, causing increase in miscarriage rates and decrease in live birth rates. Due to this age related

More information

Fertility care for women diagnosed with cancer

Fertility care for women diagnosed with cancer Saint Mary s Hospital Department of Reproductive Medicine Fertility care for women diagnosed with cancer Information For Patients INF/DRM/NUR/16 V1/01/11/2013 1 2 Contents Page Overview 4 Our Service 4

More information

IN VITRO FERTILIZATION (IVF) INFORMATION PACKAGE Form # CFRH -102 (13-Dec-2013)

IN VITRO FERTILIZATION (IVF) INFORMATION PACKAGE Form # CFRH -102 (13-Dec-2013) Centre for Fertility & Reproductive Health 250 Dundas St W., Suite 700 Toronto, ON M5T 2Z5 tel: 416-586-4748; fax: 416-586-4686 IN VITRO FERTILIZATION (IVF) INFORMATION PACKAGE Form # CFRH -102 (13-Dec-2013)

More information

FINANCIAL INFORMATION FOR PATIENTS

FINANCIAL INFORMATION FOR PATIENTS IVF Hammersmith Hammersmith Hospital Du Cane Road London W12 0HS Tel: 0203 313 4411 Fax: 0203 313 8534 www.ivfhammersmith.com IVF Hammersmith FINANCIAL INFORMATION FOR PATIENTS We hope this guide will

More information

Outcome and future of children born after ART. M. Aboulghar Professor, Cairo University Clinical Director, The Egyptian IVF center

Outcome and future of children born after ART. M. Aboulghar Professor, Cairo University Clinical Director, The Egyptian IVF center Outcome and future of children born after ART M. Aboulghar Professor, Cairo University Clinical Director, The Egyptian IVF center Possible effects on the babies could be from 1. Prematurity and multiple

More information

ORAL CONTRACEPTIVES prior to IVF. Clinical center of Vojvodina, Department of Human reproduction Prof. dr sc.med Aleksandra Trninić Pjević

ORAL CONTRACEPTIVES prior to IVF. Clinical center of Vojvodina, Department of Human reproduction Prof. dr sc.med Aleksandra Trninić Pjević ORAL CONTRACEPTIVES prior to IVF Clinical center of Vojvodina, Department of Human reproduction Prof. dr sc.med Aleksandra Trninić Pjević Paradox Treating subfertile patients with a medicine that is mainly

More information

Ottawa Fertility Centre

Ottawa Fertility Centre Ottawa Fertility Centre Financial Guide www.donoreggbankusa.com (240) 778-6210 The financial information in this guide is to provide you with a frame of reference about programs available and fees charged.

More information

Everything you ever wanted to know about embryos but were afraid to ask. EMBRYO FAQ *By Alison Coates, BSc

Everything you ever wanted to know about embryos but were afraid to ask. EMBRYO FAQ *By Alison Coates, BSc Everything you ever wanted to know about embryos but were afraid to ask. EMBRYO FAQ *By Alison Coates, BSc Q: What is the difference between a three day embryo and a blastocyst? A: An embryo that has been

More information

Price List. Initial consultation (up to 60 minutes) includes pelvic ultrasound scan (if required). 195

Price List. Initial consultation (up to 60 minutes) includes pelvic ultrasound scan (if required). 195 Price List Consultation Initial consultation (up to 60 minutes) includes pelvic ultrasound scan (if required). 195 Initial consultation (up to 60 minutes) and semen analysis includes pelvic 250 ultrasound

More information

Preimplantation Genetic Diagnosis (PGD) in Western Australia

Preimplantation Genetic Diagnosis (PGD) in Western Australia Preimplantation Genetic Diagnosis (PGD) in Western Australia Human somatic cells have 46 chromosomes each, made up of the 23 chromosomes provided by the egg and the sperm cell from each parent. Each chromosome

More information

INFERTILITY FOR THE PRIMARY CARE PROVIDER

INFERTILITY FOR THE PRIMARY CARE PROVIDER INFERTILITY FOR THE PRIMARY CARE PROVIDER Top Ten Myths Kristen E. Cain, MD FACOG Reproductive Medicine Institute Sanford Health, Fargo, ND NOTHING TO DISCLOSE The top ten myths Educational Objectives

More information

CLEAVAGE VS BLASTOCYST STAGE EMBRYO TRANSFER

CLEAVAGE VS BLASTOCYST STAGE EMBRYO TRANSFER CLEAVAGE VS BLASTOCYST STAGE EMBRYO TRANSFER 2013, Issue 6 Description of the Intervention Over the past decade there has been a steady shift in practice to transfer of embryos on Day 5 or 6 when the embryos

More information

Genetic methods for assessing embryo viability and improving IVF treatment

Genetic methods for assessing embryo viability and improving IVF treatment Genetic methods for assessing embryo viability and improving IVF treatment Prof. Dagan Wells, PhD, FRCPath Reprogenetics UK Points for discussion Diagnosis of inherited disorders in preimplantation embryos

More information

CONCEPT DOES NOT REQUIRE AN UP FRONT DEPOSIT (Except for Standard IVF/ICSI/FET where out of pocket costs must be paid in advance)

CONCEPT DOES NOT REQUIRE AN UP FRONT DEPOSIT (Except for Standard IVF/ICSI/FET where out of pocket costs must be paid in advance) Concept Fertility Centre Explanation of Fees and Request Forms (Effective 1st January 2015) INTRODUCTION All Assisted Reproductive Technology Services such as; Artificial Insemination (AI) In Vitro Fertilisation

More information

REPRODUCTIVE MEDICINE AND INFERTILITY ASSOCIATES Woodbury Medical Arts Building 2101 Woodwinds Drive Woodbury, MN 55125 (651) 222-6050

REPRODUCTIVE MEDICINE AND INFERTILITY ASSOCIATES Woodbury Medical Arts Building 2101 Woodwinds Drive Woodbury, MN 55125 (651) 222-6050 REPRODUCTIVE MEDICINE AND INFERTILITY ASSOCIATES Woodbury Medical Arts Building 2101 Woodwinds Drive Woodbury, MN 55125 (651) 222-6050 RECIPIENT COUPLE INFORMED CONSENT AND AUTHORIZATION FOR IN VITRO FERTILIZATION

More information

Veljko Vlaisavljević. Overview

Veljko Vlaisavljević. Overview 21.January 2010, ESHRE Campus Maribor Day 2-3 versus Day 5 transfer advantages and disadvantages Veljko Vlaisavljević Department of Reproductive Medicine and Gynecologic Endocrinology University Clinical

More information

Assisted reproductive technology in Australia and New Zealand 2010

Assisted reproductive technology in Australia and New Zealand 2010 Assisted reproductive technology in Australia and New Zealand 2010 ASSISTED REPRODUCTION SERIES Number 16 Assisted reproductive technology in Australia and New Zealand 2010 Alan Macaldowie Yueping A Wang

More information

SO, WHAT IS A POOR RESPONDER?

SO, WHAT IS A POOR RESPONDER? SO, WHAT IS A POOR RESPONDER? We now understand why ovarian reserve is important and how we assess it, but how is poor response defined? Unfortunately, there is no universally accepted definition for the

More information

Patient Information - Endometrial Scratch

Patient Information - Endometrial Scratch Endo Scratch Royal Devon and Exeter NHS Foundation Trust Patient Information - Endometrial Scratch Why haven t we fallen pregnant with IVF? The chance of IVF being successful and resulting in a live birth

More information

Assisted reproductive technology in Australia and New Zealand National Perinatal Epidemiology and Statistics Unit

Assisted reproductive technology in Australia and New Zealand National Perinatal Epidemiology and Statistics Unit Assisted reproductive technology in Australia and New Zealand 2013 Never Stand Still Medicine National Perinatal Epidemiology and Statistics Unit Assisted reproductive technology in Australia and New Zealand

More information

The following chapter is called "Follow-ups with a Positive or a Negative Pregnancy Test".

The following chapter is called Follow-ups with a Positive or a Negative Pregnancy Test. Slide 1 Welcome to chapter 7. The following chapter is called "Follow-ups with a Positive or a Negative Pregnancy Test". The author is Professor Pasquale Patrizio. Slide 2 This chapter has the following

More information

Ehlers-Danlos Syndrome Fertility Issues. Objectives

Ehlers-Danlos Syndrome Fertility Issues. Objectives Ehlers-Danlos Syndrome Fertility Issues Baltimore Inner Harbor Independence Day Brad Hurst, M.D. Professor Reproductive Endocrinology Carolinas Medical Center - Charlotte, North Carolina Objectives Determine

More information

INFORMED CONSENT AND AUTHORIZATION FOR IN VITRO FERTILIZATION OF PREVIOUSLY CRYOPRESERVED OOCYTES

INFORMED CONSENT AND AUTHORIZATION FOR IN VITRO FERTILIZATION OF PREVIOUSLY CRYOPRESERVED OOCYTES INFORMED CONSENT AND AUTHORIZATION FOR IN VITRO FERTILIZATION OF PREVIOUSLY CRYOPRESERVED OOCYTES We, the undersigned, as patient and partner understand that we will be undergoing one or more procedures

More information

Merton Assisted Conception and Pre-implantation Genetic Diagnosis Policy2015/16

Merton Assisted Conception and Pre-implantation Genetic Diagnosis Policy2015/16 Merton Assisted Conception and Pre-implantation Genetic Diagnosis Policy2015/16 1. Introduction 1.1 This policy describes circumstances in which Merton CCG will fund treatment for assisted conception as

More information

Preimplantation genetic diagnosis new method of screening of 24 chromosomes with the Array CGH method...2

Preimplantation genetic diagnosis new method of screening of 24 chromosomes with the Array CGH method...2 August 2012 content 8 Preimplantation genetic diagnosis new method of screening of 24 chromosomes with the Array CGH method...2 Maintaining fertility new opportunities in GENNET...3 Hysteroscopy without

More information

Frozen embryo transfer (FET)

Frozen embryo transfer (FET) PATIENT INFORMATION The Agora Gynaecology and Fertility Centre Ellen Street Brighton and Hove BN3 3LN T: 01273 229410 This leaflet has been designed to help you understand more about your FET treatment

More information

24sure TM Setting new standards in IVF

24sure TM Setting new standards in IVF 24sure TM Setting new standards in IVF 24sure TM The clinical challenge While in vitro fertilization (IVF) is a highly successful medical intervention that has revolutionized the treatment of infertility,

More information

OHTAC Recommendation. In Vitro Fertilization and Multiple Pregnancies

OHTAC Recommendation. In Vitro Fertilization and Multiple Pregnancies OHTAC Recommendation In Vitro Fertilization and Multiple Pregnancies October 19, 2006 The Ontario Health Technology Advisory Committee (OHTAC) met on October 19, 2006 and reviewed the health technology

More information

Midland Fertility Services

Midland Fertility Services Midland Fertility Services Patient Finance Information 20 Building futures, transforming lives List of Charges Prices for investigations, preservation services or treatments do not include the cost of

More information

HOW IS OVARIAN RESERVE ASSESSED?

HOW IS OVARIAN RESERVE ASSESSED? HOW IS OVARIAN RESERVE ASSESSED? The majority of indicators we have to assess OR assess egg quantity rather than egg quality and these two do not always go hand in hand. No individual test is a perfect

More information

50% Off Cycle 3 $ 9,900 $ 8,700 $ 7,500

50% Off Cycle 3 $ 9,900 $ 8,700 $ 7,500 Specialists In Reproductive Medicine & Surgery, P.A. www.dreamababy.com Fertility@DreamABaby.com Excellence, Experience & Ethics In Vitro Fertilization Price List (2015) We here at Specialists in Reproductive

More information

IVF : ; ; ; : R714.13 : A : 0253-357X(2015)03-0196-05 IVF, IVF, IVF, 5%~15% [1-4], IVF, >60% IVF, IVF ICSI , IVF IVF,

IVF : ; ; ; : R714.13 : A : 0253-357X(2015)03-0196-05 IVF, IVF, IVF, 5%~15% [1-4], IVF, >60% IVF, IVF ICSI , IVF IVF, 35 3 Vol.35 No.3 2015 3 Mar. 2015 Reproduction & Contraception doi: 10.7669/j.issn.0253-357X.2015.03.0196 E-mail: randc_journal@163.com ( 518036) : - (-ET) : >60% (n=153) (n=180) : 1 619 1 986 133 152

More information

IVF OVERVIEW. Tracy Telles, M.D.

IVF OVERVIEW. Tracy Telles, M.D. IVF OVERVIEW By Tracy Telles, M.D. Dr. Hendler: Hello and welcome to KP Healthcast. I m your host Dr. Peter Hendler and today our guest is Dr. Tracy Telles. Dr. Telles is an IVF physician in Kaiser Walnut

More information

FERTILITY AND AGE. Introduction. Fertility in the later 30's and 40's. Am I fertile?

FERTILITY AND AGE. Introduction. Fertility in the later 30's and 40's. Am I fertile? FERTILITY AND AGE Introduction Delaying pregnancy is a common choice for women in today's society. The number of women in their late 30s and 40s attempting pregnancy and having babies has increased in

More information

Commissioning Policy for In Vitro Fertilisation (IVF)/ Intracytoplasmic Sperm Injection (ICSI) within tertiary Infertility Services.

Commissioning Policy for In Vitro Fertilisation (IVF)/ Intracytoplasmic Sperm Injection (ICSI) within tertiary Infertility Services. East Midlands CCGs Commissioning Policy for In Vitro Fertilisation (IVF)/ Intracytoplasmic Sperm Injection (ICSI) within tertiary Infertility Services April 2014 CONTENTS Page 1. INTRODUCTION 3 2. GENERAL

More information

Assisted reproductive technologies (ART) in Canada: 2011 results from the Canadian ART Register

Assisted reproductive technologies (ART) in Canada: 2011 results from the Canadian ART Register 1 Assisted reproductive technologies (ART) in Canada: 2011 results from the Canadian ART Register Joanne Gunby, M.Sc. CARTR Co-ordinator Email: gunbyj@mcmaster.ca Supported by the IVF Directors Group of

More information

Midland Fertility Services Blastocyst Transfer

Midland Fertility Services Blastocyst Transfer Midland Fertility Services Blastocyst Transfer Building futures, transforming lives What is a blastocyst? When a sperm fertilises an egg the resulting embryo develops from the original single cell into

More information

The following chapter is called "Preimplantation Genetic Diagnosis (PGD)".

The following chapter is called Preimplantation Genetic Diagnosis (PGD). Slide 1 Welcome to chapter 9. The following chapter is called "Preimplantation Genetic Diagnosis (PGD)". The author is Dr. Maria Lalioti. Slide 2 The learning objectives of this chapter are: To learn the

More information

York Fertility Centre Our Services

York Fertility Centre Our Services Our Services York Fertility Centre Our Services Contents Infertility Evaluation... 3 Female Evaluation... 3 Male Evaluation... 3 Follow-Up Appointment... 4 Natural Cycle Monitoring... 4 Ovulation Induction...

More information

In Vitro Fertilization (IVF) Page 1 of 11

In Vitro Fertilization (IVF) Page 1 of 11 In Vitro Fertilization (IVF) Page 1 of 11 This document is a part of your informed consent process. Both partners should read the entire document carefully. In vitro fertilization (IVF) is a treatment

More information

Fertility Facts and Figures 2008

Fertility Facts and Figures 2008 Fertility Facts and Figures 2008 Contents About these statistics... 2 Accessing our data... 2 The scale of fertility problems... 3 Treatment abroad... 3 Contacts regarding this publication... 3 Latest

More information

THE CENTER FOR ADVANCED REPRODUCTIVE SERVICES (CARS) (The Center) CONSENT FOR IN VITRO FERTILIZATION AND EMBRYO TRANSFER

THE CENTER FOR ADVANCED REPRODUCTIVE SERVICES (CARS) (The Center) CONSENT FOR IN VITRO FERTILIZATION AND EMBRYO TRANSFER THE CENTER FOR ADVANCED REPRODUCTIVE SERVICES (CARS) (The Center) CONSENT FOR IN VITRO FERTILIZATION AND EMBRYO TRANSFER Partner #1 Last Name (Surname): Partner #1 First Name: Partner #1 Last 5 Digits

More information

Fertility Treatment - Glossary

Fertility Treatment - Glossary {loadpositionaddthis} Fertility Treatment - Glossary Adoption: The legal process in which a couple adopt parents. a child and become its legal Annovulatory: Absence of ovulation. Antral Follicles: Smaller

More information

Fertility Treatment Commissioning Policy Criteria Based Access Exceptional funding required for any patients that do not meet the criteria specified

Fertility Treatment Commissioning Policy Criteria Based Access Exceptional funding required for any patients that do not meet the criteria specified Fertility Treatment Commissioning Policy Criteria Based Access Exceptional funding required for any patients that do not meet the criteria specified Fertility Treatment - Pre Implantation Genetic Diagnosis

More information

Consent to Perform Preimplantation Genetic Screening (PGS) using. Comparative Genomic Hybridization (acgh) or Next Generation Sequencing (NGS)

Consent to Perform Preimplantation Genetic Screening (PGS) using. Comparative Genomic Hybridization (acgh) or Next Generation Sequencing (NGS) Consent to Perform Preimplantation Genetic Screening (PGS) using Array Comparative Genomic Hybridization (acgh ) or Next Generation Sequencing (NGS) Purpose The purpose of Preimplantation Genetic Screening

More information

In Vitro Fertilisation (IVF)

In Vitro Fertilisation (IVF) Mr Nabil Haddad M. OBSTET, GYNAEC, FRCOG Consultant Gynaecologist Patient Information In Vitro Fertilisation (IVF) What is In Vitro Fertilisation (IVF) Mr Nabil Haddad Consultant Gynaecologist What is

More information

Lesbian Pregnancy: Donor Insemination

Lesbian Pregnancy: Donor Insemination Lesbian Pregnancy: Donor Insemination (Based on an article originally published in the American Fertility Association 2010 National Fertility and Adoption Directory. Much of this information will also

More information

NICE Pathways bring together all NICE guidance, quality standards and other NICE information on a specific topic.

NICE Pathways bring together all NICE guidance, quality standards and other NICE information on a specific topic. bring together all NICE guidance, quality standards and other NICE information on a specific topic. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published.

More information

East Midlands CCGs Commissioning Policy for In Vitro Fertilisation (IVF)/ Intracytoplasmic Sperm Injection (ICSI) within tertiary Infertility Services

East Midlands CCGs Commissioning Policy for In Vitro Fertilisation (IVF)/ Intracytoplasmic Sperm Injection (ICSI) within tertiary Infertility Services East Midlands CCGs Commissioning Policy for In Vitro Fertilisation (IVF)/ Intracytoplasmic Sperm Injection (ICSI) within tertiary Infertility Services November 2013 Reference Number: CG023 Version: 5.0

More information

Informed Consent Packet - In Vitro Fertilization (IVF)

Informed Consent Packet - In Vitro Fertilization (IVF) Center for Reproductive Medicine (CRM) Informed Consent Packet - In Vitro Fertilization (IVF) This packet contains the required IVF treatment consent documents. Please read, consider and, if you agree,

More information

Preimplantation Diagnosis for Monogenic Disorders

Preimplantation Diagnosis for Monogenic Disorders Preimplantation Diagnosis for Monogenic Disorders Many serious genetic diseases are caused by an error, or mutation, in a precise location in a particular gene. Preimplantation Genetic Diagnosis (PGD)

More information

FINANCIAL INFORMATION FOR PATIENTS

FINANCIAL INFORMATION FOR PATIENTS FINANCIAL INFORMATION FOR PATIENTS We hope this guide will help you assess the cost of your investigation tests and treatment fees. It provides information about what is included in the cost, when and

More information

A POWERFUL IN VITRO FERTILIZATION

A POWERFUL IN VITRO FERTILIZATION A POWERFUL During the past 50 years technological advances in the field of bovine reproduction have led to some dramatic changes in the way cattle look, reproduce, perform, and even taste. Artificial Insemination

More information

CONSENT FOR THE CRYOPRESERVATION (FREEZING) OF HUMAN EMBRYOS

CONSENT FOR THE CRYOPRESERVATION (FREEZING) OF HUMAN EMBRYOS CENTER FOR HUMAN REPRODUCTION 21 East 69th Street, New York, NY 10021 212-994-4400 ext 4406 Fax: 212-994-4499 FEMALE PATIENT S NAME: Medical Record # CONSENT FOR THE CRYOPRESERVATION (FREEZING) OF HUMAN

More information

Welcome to chapter 2. The following chapter is called "Indications For IVF". The author is Dr Kamini A. Rao.

Welcome to chapter 2. The following chapter is called Indications For IVF. The author is Dr Kamini A. Rao. Welcome to chapter 2. The following chapter is called "Indications For IVF". The author is Dr Kamini A. Rao. The indications for an IVF treatment have increased since the birth of the first IVF baby. The

More information

Reduced Ovarian Reserve Is there any hope for a bad egg?

Reduced Ovarian Reserve Is there any hope for a bad egg? Reduced Ovarian Reserve Is there any hope for a bad egg? Dr. Phil Boyle Galway Clinic, 19 th March 2014 For more information on Low AMH see www.napro.ie Anti Mullerian Hormone AMH levels are commonly measured

More information

The cost-effectiveness of IVF in the UK: a comparison of three gonadotrophin treatments Sykes D, Out H J, Palmer S J, van Loon J

The cost-effectiveness of IVF in the UK: a comparison of three gonadotrophin treatments Sykes D, Out H J, Palmer S J, van Loon J The cost-effectiveness of IVF in the UK: a comparison of three gonadotrophin treatments Sykes D, Out H J, Palmer S J, van Loon J Record Status This is a critical abstract of an economic evaluation that

More information