National Birth Defect Registry
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- Timothy Wilcox
- 3 years ago
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From this document you will learn the answers to the following questions:
What type of preconceptual exposure does the National Birth Defect Registry collect data on?
What is the cause of birth defects?
Transcription
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2 National Birth Defect Registry Based on concept of alert practitioner Identifies patterns of birth defects with the same or similar exposures Collects data on maternal/paternal preconceptual and prenatal exposures Cases dually identified by individual symptoms and overall syndrome or category name Designed to raise hypotheses
3 Teratogens Identified by Alert Practitioners Thalidomide Rubella Dilantin DES Alcohol Methyl Mercury Radiation
4 Scientific Advisory Board Peter Kahn, Ph.D. Rutgers University James Murphy, Ph.D. University of Colorado Theo Colborn, Ph.D. World Wildlife Fund Stuart Newman, Ph.D. New York Medical College Shanna Swan, Ph.D. California Department of Health Services Maureen Paul, M.D. University of Massachusetts Wayland Swain, Ph.D. Eco Logic Company Janette Sherman, M.D. Wayne State University
5 Registry Projects Bendectin Agent Orange Gulf War Community based - Dickson, TN - oral cleft cluster
6 Gulf War Exposures DEET Permethrin Pyridostigmine Pentachlorophenol Benzocaine sulfur Aluminum phospide Baygon Boric Acid Sevin Amidinohydrazone Diazinon Dursban Dichlorvos Ficam Carbaryl Lindane Malathion Oil Well Fires Leaded fuels Depleted Uranium Solvents Decontam agent Malaria Pills Campfires Leishmaniasis Chemical warfare agents CARC Vaccinations D-phenothrin Allethrin Paint Others
7 Disability Frequency Resp. Infect. 117 Ear Infect. 92 Motor Delay 86 Colic as Baby 62 Speech 62 Allergies 57 Jaundice 56 Reflux 52 Heart Murmur 51 High Fevers 46 Ext. Ears 40 Asthma 38 Food Sens. 38 Eczema 35 VSD 35 Drug Reaction 34 Hypotonia 34 Seizures 33 Acne-like Rash 33 Thrush 32 Mood Swings 32 Pneumonia 29 Birth Mark 28 Stomach problems 28 Sleep disorder 26 Walks on tiptoes 26 Goldenhar 26 Up. Limb Reduction 25
8 Male-Mediated Birth Defects Evidence from Experimental and Epidemiological Studies Toluene Benzene Lead/mercury Trichloroethane Solvents Dyes Cigarette smoke/alcohol Drugs Possible Outcomes Congenital malformations Spontaneous abortions Low birth weight Childhood cancers Developmental, neurobehavioral, neuroendocrine, neurochemical abnormalities
9 Birth Defect Research for Children, Inc. 3 National Birth Defect Registry Children of GW Vets/ Non-GW Vets Gulf War Non-GW Anencephaly Cortical Blindness N=3137 GW VETERAN: 410 NON-GW VET: 2727 CNS Comp Cases per 100
10 12 Birth Defect Research for Children, Inc. National Birth Defect Registry Children of GW Vets/ Non-GW Vets Gulf War Non-GW 2 0 AB/Undeveloped Lung Intern Ears Ex Ear Defects N=3137 GW VETERAN: 410 NON-GW VET: 2727 Lung/Ear Comp Cases per 100
11 Birth Defect Research for Children, Inc. National Birth Defect Registry Children of GW Vets/ Non-GW Vets Trans Gr Vessels Tetra of Fallot VSD ASD 3.04 Gulf War Non-GW N=3137 GW VETERAN: 410 NON-GW VET: 2727 Heart Defects Comp Cases per 100
12 Birth Defect Research for Children, Inc. National Birth Defect Registry Children of GW Vets/ Non-GW Vets Endo Cushion Def Pulm Valve Sten Tricus Valve Sten Cardiomegaly Gulf War Non-GW N=3137 GW VETERAN: 410 NON-GW VET: 2727 Heart Defects Comp Cases per 100
13 4 Birth Defect Research for Children, Inc. National Birth Defect Registry Children of GW Vets/ Non-GW Vets Gulf War Non-GW Hypo Left Heart Patent Ductus Coart Aorta Pulm Atresia N=3137 GW VETERAN: 410 NON-GW VET: 2727 Heart Defects Comp Cases per 100
14 7 Birth Defect Research for Children, Inc. National Birth Defect Registry Children of GW Vets/ Non-GW Vets Gulf War Non-GW Trisomy Goldenhar Turners N=3137 GW VETERAN: 410 NON-GW VET: 2727 Syndromes Comp Cases per 100
15 0.6 Birth Defect Research for Children, Inc. National Birth Defect Registry Children of GW Vets/ Non-GW Vets Gulf War Non-GW TAR Cri Du Chat DiGeorge N=3137 GW VETERAN: 410 NON-GW VET: 2727 Syndromes Comp Cases per 100
16 35 30 Birth Defect Research for Children, Inc. National Birth Defect Registry Children of GW Vets/ Non-GW Vets Gulf War Non-GW 0 Up Res Infect Ear Infections Immune Def Thrush Unexplained Fevers N=3137 GW VETERAN: 410 NON-GW VET: 2727 Immune Comp Cases per 100
17 Goldenhar Syndrome Incidence ranges from 1/14,699 to 1/45,000 births Associated with teratogens - Thalidomide - Primidone - Accutane Some cases familial Others phenocopies Aranetta study found tripling of Goldenhar in GW children born in military hospitals
18 Goldenhar Case Study 24 Goldenhar fathers deployed 7 Goldenhar critera fathers deployed 2 Goldenhar fathers in Gulf after war 33 Goldenhar associated with Gulf service
19 Goldenhar Case Study 7 Goldenhar fathers non-deployed Steel worker Shots/solvents Cont gear Shots/Naptha Shots/lead fuel mechanic Cont gear
20 Goldenhar Case Rates 16 D Goldenhar DOB prior 10/1/93 3 ND Goldenhar DOB prior 10/1/93 56,782 births to deployed vets* 68,908 births to non-deployed vets* Crude rates for Goldenhar: Deployed 28 per 100,000 Non-deployed 4 per 100,000 *Araneta, Teratology, 1997.
21 Goldenhar Details Medical records confirmation 14/19 9/16 healthy children before GW 2/16 healthy children after birth of child with Goldenhar Syndrome 16/16 Goldenhar first born after GW
22 Goldenhar Case Study DOB Distribution Goldenhar cases
23 All GW Birth Defects DOB Distribution All BDs
24 Pubished Studies 1997 Teratology Aranetta - tripling of Goldenhar Syndrome in GWV infants born in military hospitals 2001 Ann of Epidemiology Kang increased reporting of birth defects significantly associated with military service in the Gulf War 2003 Birth Defects Research Aranetta higher prevalence of tricuspid valve insufficiency, aortic valve stenosis and renal agenesis in infants conceived postwar by GWV fathers; hypospadias in boys born to GWV mothers 2004 Internat. J. of Epidemiology Doyle increased risk of miscarriage, malformations of genital system, urinary system, digestive system, musculo-skeletal system and non-chromosome anomalies in children of GWV fathers
25 National Birth Defect Registry Now available on-line 24 hours a day.. sponsored by Birth Defect Research for Children
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