Incidence of Malignant Pleural Mesothelioma due to Environmental Asbestos Fiber Exposure in the Southeast of Turkey
|
|
- Darcy Cameron
- 8 years ago
- Views:
Transcription
1 Clinical Investigations Respiration 2000;67: Received: November 26, 1999 Accepted after revision: June 27, 2000 Incidence of Malignant Pleural Mesothelioma due to Environmental Asbestos Fiber Exposure in the Southeast of Turkey A. Şenyiğit a C. Babayiğit a M. Gökirmak c F. Topçu a E. Asan a M. Coşkunsel a R. Işık a M. Ertem b a Department of Chest Diseases and b Department of Public Health, Faculty of Medicine, University of Dicle, Diyarbakır, c Department of Chest Diseases, Faculty of Medicine, University of İnönü, Malatya, Turkey For editorial comment see p Key Words Asbestos W Malignant pleural mesothelioma W Epidemiology Abstract Background: Inhabitants of the southeast of Turkey (ST) have been exposed since childhood to inhalation of asbestos, from a material containing tremolite, used for whitewashing. This has resulted in an increased incidence of malignant pleural mesothelioma (MPM). Objectives: To review the epidemiological features of MPM cases in ST; to calculate and compare the incidence with the previously reported ones. Subjects and Methods: The study included 176 MPM cases from different places in ST. The incidence of MPM was calculated for those places according to the distribution of the cases. Results: In the previously identified regions of asbestos (region 1) where the population had been informed of the danger with the soil some decades ago, the MPM incidence was decreased, as compared to the previous reports. The annual incidence of MPM in these places was found to be 42.9 per million in this study while it had been reported to be per million in the previous studies. In contrast, the incidence that was reported previously to be 2.75 per million in the regions where asbestos exposure had not been identified before (region 2) was found to be 8.6 per million in this study. In region 2 the incidence of MPM increased even in the second half of the last decade (5.9 versus 11.9 per million). Conclusions: Use of asbestos-containing soil continues in different places in ST. Even if the use of this soil is abandoned today, MPM will be an important health problem in this region till the third or fourth decades of this century. Informing the villagers of the danger and preventing the use of this soil may result in a considerable decrease in the incidence of MPM. Introduction Copyright 2000 S. Karger AG, Basel Malignant pleural mesothelioma (MPM) is an incurable disease which is almost exclusively due to inhalation of asbestos fibers [1, 2]. The disease is one of the major health problems in Turkey [3]. This is due to the many ABC Fax karger@karger.ch S. Karger AG, Basel /00/ $17.50/0 Accessible online at: Abdurrahman Şenyigit Tıp Fakültesi Göğüs Hastalıkları, Diyarbakır (Turkey) Tel /4287 or 4270, Fax senyigit@dicle.edu.tr
2 asbestos deposits which exist in some rural parts of central and eastern Anatolia [3 5]. The people living in the southeast of Turkey (ST) were also reported to have a high incidence of MPM due to environmental asbestos exposure [6, 7]. The material containing asbestos is quarried from the mountains by the male population both for local use and for sale elsewhere. It is used as a whitewash for the walls and floors of the houses. The application is usually done by women who grind the material to powder and suspend it in water. The process is repeated each year. Consequently householders are repeatedly exposed from an early age [4, 6]. There is a large variation in the incidence of mesothelioma in different countries and in most places a steadily rising number of cases with time [2]. The studies investigating the incidence of MPM in Turkey are little in number, and most of them report the rates of disease in small places like villages [8 16]. This study analyzing a large series of MPM patients is the first one to investigate the incidence of MPM in most places in ST and to compare the results with the previously reported ones in order to detect the changes in incidence. The objectives of the present study were: (i) to identify all new cases of MPM diagnosed in ST over a specified period ( ) with a view to estimating incidence; (ii) to compare the calculated incidence with previously reported rates from the same region, and (iii) to describe some features of MPM patients, including age, sex, and association with asbestos exposure. Subjects and Methods This study is designed to investigate the incidence of MPM in ST. The patients who were diagnosed to have mesothelioma in a reference university hospital between the years 1990 and 1999 are included in the study. Mesotheliomas are only accepted in the register if they are based on histological or cytological examinations. The pathological diagnosis is made on the basis of ordinary tissue sections stained with hematoxylin-eosin; further immunohistochemical stains are used as needed. The information about the patients including age, sex and birthplace were extracted from the records. The history of occupational or environmental exposure to mineral fibers or chemicals was analyzed carefully. Asbestos exposure was noted as positive for patients from places where environmental asbestos was known to exist. A number of patients came from places where environmental asbestos had not been reported previously. These areas were referred to as region 1, while the areas where asbestos exposure was not identified before were named as region 2. Soil samples from different places in region 2 were investigated by electron microscopy. The data for populations living in areas of interest could only be taken for the years 1990 and 1997 from the State Institute of Statistics. Then, the annual population figures were calculated for each Fig. 1. The age distribution of 176 MPM patients. year for the period covered by the study by using the annual rate of increase in population in these areas. The incidence calculated using these population figures was compared with the rates reported in previous studies. Results One hundred (57%) of the 176 patients were men and 76 (43%) were women, giving a male/female ratio of 1.3/1. The ages of female and male patients ranged from 21 to 79 (mean 54.2) and from 25 to 77 (mean 52.4) years, respectively. The age distribution of cases is shown in figure 1. Thirteen percent of the patients were diagnosed as MPM by cytological examination of the pleural fluid, while histopathological examination of pleural biopsies or lymph nodes (1 case) revealed the diagnosis in 83% of the cases. There was a positive history of asbestos exposure in 60% of cases. Analysis of soil samples from all places of region 2 by electron microscopy showed both serpentine (little in amount) and amphibole (tremolite) type asbestos fibers in only 4 of them. When the patients coming from the recently identified four places with asbestos exposure in region 2 were also considered, the overall ratio of the patients with a history of asbestos exposure increased to 68%. The distribution of the patients according to the history of asbestos exposure is seen in table 1. As is seen in this table, none of the cases had occupational or industrial exposure to asbestos. The regional distribution of the patients and the calculated incidence for the first and second half of the last decade are shown in table 2. The incidence of MPM was found to be 42.9 and 8.6 per million in regions 1 and 2, Mesothelioma due to Environmental Asbestos Exposure Respiration 2000;67:
3 Table 1. The distribution of patients according to the history of asbestos exposure Asbestos exposure Male (n = 100) Female (n = 76) Evironmental Occupational 0 0 Industrial 0 0 None Represents all cases from region 1 and the recently identified four places with asbestos exposure in region 2. Table 2. The regional distribution of the patients and incidence of MPM per million population of towns/cities in ST City or town in Turkey Cases per 1,000,000 inhabitants * * * Previously identified areas of asbestos (region 1) Maden (n = 19) Ergani (n = 39) Çüngüş (n = 6) Çermik (n = 18) Siverek (n = 23) Total (n = 105) 47.2 a 37.5 a 42.9 a Areas where asbestos was not identified before (region 2) Dicle (n = 14) Mardin (n = 10) Silvan (n = 5) Batman (n = 8) Elazığ (n = 10) (excluding Maden) Şanlıurfa (n = 8) (excluding Siverek) Others** (n = 16) Total (n = 71) 5.9 b 11.9 b 8.6 b Incidence in total population in these places. Diyarbakır (excluding Çermik, Çüngüş, Ergani, Dicle, Silvan), Bingöl, Adıyaman, Şırnak, Siirt, Bitlis, Muş. a b respectively. The incidence of MPM in ST was calculated to be 22.8 per million. As shown in table 2, the incidence of the disease increased considerably in region 2 between the years 1990 and The increase in incidence was even greater in the second half of this decade when compared to the first half (5.9 versus 11.9 per million). Fig. 2. The changes in incidence of MPM in region 1 and region 2. [The data for are from ref. 17.] The changes in incidence of MPM according to the results of this and a previous study are shown in figure 2 [17]. Also asbestos outcrops and patient birthplaces are precisely plotted on a map showing the ST, in figure 3. Discussion This study shows that the risk of pleural mesothelioma is increasing in some parts of ST. The decrease in incidence of MPM in region 1 is mostly due to awareness of the people living there of the danger related to this soil and the resultant decrease in usage of it. The high sex prevalence for males in most countries is strong evidence for occupational exposure to asbestos, since females are less likely to have worked in contaminated areas [18 21]. The calculated male/female ratio, however, is 1.3 in this study. There are two reasons that explain the higher prevalence of MPM in females in Turkey compared to other countries. One reason is the wider use of asbestos-containing soil by women although the men are the ones who dig and transport the mineral. Secondly, although women usually cover their mouths and noses during whitewashing, they are still the ones predominantly engaged in household tasks. In industrialized countries where asbestos was widely used from the end of World War II until the end of the 1970s, the incidence per year of mesothelioma is presently 2 per million in females and per million in males. Geographical variations in incidence are due to regional differences in industrial activity. Regions with 612 Respiration 2000;67: Şenyiğit/Babayiğit/Gökirmak/Topçu/Asan/ Coşkunsel/Işık/Ertem
4 Fig. 3. Map showing the ST and asbestos outcrops (n represents the number of cases who were born in that place). shipyards are particularly at high risk. In the USA, the highest published annual rate per million is 13.3 for males and 2.5 for females and in Australia the rates are 66 per million for males and 7 per million for females [21]. According to the results of this study the incidence of MPM in seven areas of Turkey is higher than that of the USA, which is an industrialized country. The incidence found in one of the towns investigated (Maden) was also higher than the rates found in Australia. Asbestos is not used in industry in ST except for a pipe factory. And also, none of the patients with MPM worked in this factory or lived near it. So, none of the patients was shown to have an occupational exposure. In the five previously known areas, the digging and use of asbestos-containing soil has almost completely ended. However, in the four newly recognized places (shown on the map) people still dig and use this soil. Dicle, in which the incidence of MPM was found to be 35.9 per million (the fourth highest incidence), is one of those newly detected places. Since the incidence of disease was found to be increased in region 2 compared to the previous studies, and since this increase was even greater in the second half of the last decade compared to the first half, MPM will probably continue to be an important health problem of the region. This is due to the long latency period of mesothelioma which can explain a rise in the incidence of disease for up to years after the application of strict laws on the use of this mineral fiber. In the present study, changes in the incidence of MPM in ST since 1976 were also investigated. Although the incidence of disease was found to be very high in region 1 (42.9 per million) compared to region 2 (8.6 per million), this was still lower than in previous studies reporting an incidence of per million for region 1 [17]. Asbestoscontaining soil is still being used in some villages and towns where the danger is not known, while in region 1 this soil has not been used for a long time, since the disease was first noticed there and in fact was called as Çermik s Disease in the region. This illustrates how important it is to detect the asbestos and inform the villagers of the danger. Since the exposure is due to whitewashing of the houses, the risk will considerably decrease if this pro- Mesothelioma due to Environmental Asbestos Exposure Respiration 2000;67:
5 cedure is stopped. When the long latency period is considered, however, the risk will even continue until the second decade of this century, since the use of the soil was stopped in the early 1980s. In addition, the calculated incidence of MPM may be less than the real incidence of the disease in ST, because many districts of the region are underserved by health services and the diagnosis of MPM is not likely to be made clinically. There might also be some patients with suspected MPM who could not be diagnosed by closed pleural biopsy and rejected the more invasive diagnostic procedures. In addition, these places are the most prevalent ones from which people migrate to the big cities. Another factor influencing incidence is the type of fiber used, the incidence being higher with crocidolite and amosite than with chrysotile [21]. Tremolite appears, dose for dose, to be more carcinogenic than chrysotile, but it is regarded by Churg as a low-grade carcinogen [22]. Since the exposed fiber in this study and the previous studies from Turkey was tremolite [6, 8], this fiber should also be considered as a very important carcinogen. The importance of tremolite has been underlined by McDonald et al. [22]. These authors felt that the tremolite contaminating many industrial minerals, including chrysotile, probably explained most of the cases in the Quebec mining region and perhaps up to 20% of cases elsewhere [22]. As is seen in figure 3, the newly detected regions of asbestos are in the neighborhood of the previously known regions and the whole region seems to be on a fault line. The asbestos fibers found in many neighbor countries of Turkey are also tremolite [2]. As a conclusion, this study reveals the extent of MPM in ST and gives support to public health concern for more stringent environmental control of this fiber. The decrease in the incidence of disease in region 1 is thought to be primarily due to informing the villagers of the danger. In view of the latency period in the development of MPM after asbestos exposure, it will take many decades before the effect of such controls will be seen. References 1 Albelda SM, Sterman DH, Litzky LA: Malignant mesothelioma and other primary pleural tumors, in Fishman AP (ed): Fishman s Pulmonary Diseases and Disorders. New York, McGraw-Hill, 1998, pp Hillerdal G: Mesothelioma: Cases associated with non-occupational and low dose exposures. Occup Environ Med 1999;56: Selçuk ZT, Çöplü L, Emri S, Kalyoncu AF, Şahin AA, Barış Yİ: Malignant pleural mesothelioma due to environmental mineral fiber exposure in Turkey: Analysis of 135 cases. Chest 1992;102: Yılmaz UM, Utkaner G, Yalnız E, Kumcuoğlu Z: Computed tomographic findings of environmental asbestos-related malignant pleural mesothelioma. Respirology 1998;3: Şahin AA, Çöplü L, Selçuk ZT, Eryılmaz M, Emri S, Akhan O, Barış Yİ: Malignant pleural mesothelioma caused by environmental exposure to asbestos or erionite in rural Turkey: CT findings in 84 patients. AJR 1993;161: Yazıcıoğlu S, İlçayto R, Balcı K, Saylı BS, Yorulmaz B: Pleural calcification, pleural mesotheliomas, and bronchial cancers caused by tremolite dust. Thorax 1980;35: Yazıcıoğlu S: Pleural calcification associated with exposure to chrysotile asbestos in southeast Turkey. Chest 1976;70: Cöplü L, Dumortier P, Demir AU, Selçuk ZT, Kalyoncu F, Kisacik G, DeVuyst P, Sahin AA, Baris YI: An epidemiological study in an Anatolian village in Turkey environmentally exposed to tremolite asbestos. J Environ Pathol Toxicol Oncol 1996;15: Artvinli M, Baris YI: Malignant mesothelioma in a small village in the Anatolian region of Turkey: An epidemiologic study. J Natl Cancer Inst 1979;63: Baris YI, Saracci R, Simonato L, Skidmore JW, Artvinli M: Malignant mesothelioma and radiological chest abnormalities in two villages in Central Turkey. An epidemiological and environmental investigation. Lancet 1981;i: Artvinli M, Baris YI: Environmental fiberinduced pleuro-pulmonary diseases in an Anatolian village: An epidemiologic study. Arch Environ Health 1982;37: Baris I, Simonato L, Artvinli M, Pooley F, Saracci R, Skidmore J, Wagner C: Epidemiological and environmental evidence of the health effects of exposure to erionite fibres: A four-year study in the Cappadocian region of Turkey. Int J Cancer 1987;39: Baris YI, Bilir N, Artvinli M, Sahin AA, Kalyoncu F, Sebastien P: An epidemiological study in an Anatolian village environmentally exposed to tremolite asbestos. Br J Ind Med 1988;45: Baris I, Artvinli M, Sahin A, Savas T, Erkan ML: Occurrence of pleural mesothelioma: Chronic fibrosing pleurisy and calcified pleural plaques in Turkey in relation with environmental pollution by mineral fibers (in French). Rev Fr Mal Respir 1979;7: Baris YI, Artvinli M, Sahin AA: Environmental mesothelioma in Turkey. Ann N Y Acad Sci 1979;330: Metintas M, Hillerdal G, Metintas S: Malignant mesothelioma due to environmental exposure to erionite: Follow-up of a Turkish emigrant cohort. Eur Respir J 1999;13: Yazıcıoğlu S, Öktem K, İlçayto R, Balcı K, Şaylı BS: Association between malignant tumors of the lung and pleurae and asbestosis. A retrospective study. Chest 1978;73: Schwartz DA: New developments in asbestosinduced pleural disease. Chest 1991;99: Adams VI, Unnı KK, Muhm JR, Jett JR, Ilstrup DM, Bernatz PE: Diffuse malignant mesothelioma of pleura: Diagnosis and survival in 92 cases. Cancer 1986;58: Brenner J, Sordillo PP, Magill GB, Goldey RB: Malignant mesothelioma of the pleura: Review of 123 patients. Cancer 1982;49: Boutin C, Schlesser M, Frenay C, Astoul Ph. Malignant pleural mesothelioma. Eur Respir J 1998;12: Hasleton PS: Pleural disease; in Hasleton PS (ed): Spencer s Pathology of the Lung. New York, McGraw-Hill, 1996, pp Respiration 2000;67: Şenyiğit/Babayiğit/Gökirmak/Topçu/Asan/ Coşkunsel/Işık/Ertem
Malignant Pleural Mesothelioma Caused by Environmental Exposure to Asbestos in the Southeast of Turkey: CT Findings in 117 Patients
Clinical Investigations Respiration 2000;67:615 622 Received: August 6, 1999 Accepted after revision: June 27, 2000 Malignant Pleural Mesothelioma Caused by Environmental Exposure to Asbestos in the Southeast
More informationThe incidence of mesothelioma has not decreased for the last twenty years in Southeast region of Anatolia
The incidence of mesothelioma has not decreased for the last twenty years in Southeast region of Anatolia Carkanat AI 1, *Abdurrahman A 1, Abakay O 2, Cengizhan S 1, Selimoglu SH 1, Senyigit A 1 1. Department
More informationDetermination of Environmental Exposure to Asbestos (Tremolite) and Mesothelioma Risks in the Southeastern Region of Turkey
Determination of Environmental Exposure to Asbestos (Tremolite) and Mesothelioma Risks in the Southeastern Region of Turkey ABDURRAHMAN SENYIGIT Dicle University Faculty of Medicine Department of Chest
More informationHealth Effects of Asbestos Exposure
Health Effects of Asbestos Exposure Jill Dyken, PhD, PE John Wheeler, PhD, DABT Agency for Toxic Substances and Disease Registry Asbestos Science Seminar Folsom, California August 18-19, 2004 Agency for
More informationInfluence of Fiber Type, Size, and Number in Human Disease: Conclusions from Fiber Burden Analysis
Influence of Fiber Type, Size, and Number in Human Disease: Conclusions from Fiber Burden Analysis Andrew Churg, MD Department of Pathology University of British Columbia Vancouver, BC, Canada Techniques,
More informationCurrent Usage and Health Significance of the Modern Use of Chrysotile Products: Review of Recently Published Evidence
Current Usage and Health Significance of the Modern Use of Chrysotile Products: Review of Recently Published Evidence John Hoskins Health & Safety Consultant, Haslemere, Surrey, UK ASBESTOS SERPENTINE
More informationAsbestos Health Risks. Dr Andrew Pengilley Acting Chief Health Officer
Asbestos Health Risks Dr Andrew Pengilley Acting Chief Health Officer Asbestos Asbestos is a name given to several different fibrous minerals Three main commercial types are Chrysotile (white asbestos)
More informationDetermination of Asbestos Exposure by Pathology and Clinical History
16 Determination of Asbestos Exposure by Pathology and Clinical History Allen R. Gibbs The determination of whether an abnormal asbestos exposure took place is important in mesothelioma cases because of
More informationNHS Barking and Dagenham Briefing on disease linked to Asbestos in Barking & Dagenham
APPENDIX 1 NHS Barking and Dagenham Briefing on disease linked to Asbestos in Barking & Dagenham 1. Background 1.1. Asbestos Asbestos is a general name given to several naturally occurring fibrous minerals
More informationUses and Abuses of Pathology in Asbestos-exposed Populations
Uses and Abuses of Pathology in Asbestos-exposed Populations Jerrold L. Abraham, MD Department of Pathology State University of New York Upstate Medical University Syracuse, NY, 13210 USA The term: Asbestosis,
More informationChanging Trends in Mesothelioma Incidence. Hans Weill, M.D. Professor of Medicine Emeritus Tulane University Medical Center
Changing Trends in Mesothelioma Incidence Hans Weill, M.D. Professor of Medicine Emeritus Tulane University Medical Center International Conference on Chrysotile Montreal, May 23, 2006 Global Mesothelioma
More informationFrancine Lortie-Monette, MD, MSc, CSPQ, MBA Department of Epidemiology and Biostatistics University of Western Ontario 2003
ASBESTOS Francine Lortie-Monette, MD, MSc, CSPQ, MBA Department of Epidemiology and Biostatistics University of Western Ontario 2003 Asbestosis Asbestosis is a model for other dust diseases as well as
More informationHEALTH CARE FOR EXPOSURE TO ASBESTOS. 2010 The SafetyNet Centre for Occupational Health and Safety Research Memorial University www.safetynet.mun.
HEALTH CARE FOR PATIENTS WITH EXPOSURE TO ASBESTOS 2010 The SafetyNet Centre for Occupational Health and Safety Research Memorial University www.safetynet.mun.ca HEALTH CARE FOR PATIENTS WITH EXPOSURE
More informationAsbestos and Mesothelioma a briefing document for the Metropolitan Police
Asbestos and Mesothelioma a briefing document for the Metropolitan Police Prepared by Professor John Cherrie, Heriot Watt University, Edinburgh, UK. Introduction The purpose of this document is to provide
More informationAsbestos related health risks
Asbestos related health risks Pascal DUMORTIER *,** & Paul DE VUYST** *a-ulab ** Chest Department Hopital ERASME Asbestos related health risks Asbestos : some facts Asbestos related diseases Detection
More informationTable 2.4. Summary of design and findings from mesothelioma case-control studies
categories Agudo et al. (2000) Barcelona and Cadiz, Spain 32 cases (77% males) of histologically con rmed malignant pleural mesothelioma identified from hospital in the region between //993 and 2/3/996.
More informationORIGINAL ARTICLE. Serum Levels of Alpha-Tocopherol, Vitamin C, Beta-Carotene, and Retinol in Malignant Pleural Mesothelioma
DOI:http://dx.doi.org/10.7314/APJCP.2012.13.7.3025 ORIGINAL ARTICLE Serum Levels of Alpha-Tocopherol, Vitamin C, Beta-Carotene, and Retinol in Malignant Pleural Mesothelioma Salih Emri 1, Saadettin Kilickap
More informationToxicity of Amphibole Asbestos
Toxicity of Amphibole Asbestos Disclaimer: The material presented in these slides has been reviewed by the U.S. EPA and approved for presentation. Approval does not signify that the contents necessarily
More informationAsbestos: health effects and risk. Peter Franklin Senior Scientific Officer, EHD Senior Research Fellow, UWA
Asbestos: health effects and risk Peter Franklin Senior Scientific Officer, EHD Senior Research Fellow, UWA What is asbestos Naturally occurring mineral that has crystallised to form long thin fibres and
More informationHANDLING LUNG CANCER CLAIMS
HANDLING LUNG CANCER CLAIMS JENNIFER S. KILPATRICK SWANSON, MARTIN & BELL, LLP 330 North Wabash Avenue Suite 3300 Chicago, Illinois 60611-3604 (312) 321-3517 (312) 321-0990 jkilpatrick@smbtrials.com 1
More informationHealth effects of occupational exposure to asbestos dust
Health effects of occupational exposure to asbestos dust Authors: N.Szeszenia-Dąbrowska, U.Wilczyńska The major health effects of workers' exposure to asbestos dust include asbestosis, lung cancer and
More informationOccupational respiratory diseases due to Asbestos. Dirk Dahmann, IGF, Bochum
Occupational respiratory diseases due to Asbestos Dirk Dahmann, IGF, Bochum Contents Introduction Diseases Further Effects Preventive Strategies Conclusion Asbestos minerals Woitowitz, 2003 Imports (+
More informationASBESTOS DISEASES. Dr Alastair Robertson
ASBESTOS DISEASES Dr Alastair Robertson Occupational Health Department University Hospital Birmingham Birmingham B29 6JF 01216278285 Alastair.robertson@uhb.nhs.uk Occupational Lung Disease Unit Birmingham
More informationAsbestos, Asbestosis, and Lung Cancer
Asbestos, Asbestosis, and Lung Cancer David Weill, M.D. Stanford University Medical Center Stanford, CA David Weill, M.D., is a professor of medicine in the Division of Pulmonary and Critical Care Medicine
More informationTranscript for Asbestos Information for the Community
Welcome to the lecture on asbestos and its health effects for the community. My name is Dr. Vik Kapil and I come to you from the Centers for Disease Control and Prevention, Agency for Toxic Substances
More informationEmerging evidence that the ban on asbestos use is reducing the occurrence of pleural mesothelioma in Sweden
596500SJP0010.1177/1403494815596500B. Järvholm and A. BurdorfAsbestos ban reduces mesothelioma incidence research-article2015 Scandinavian Journal of Public Health, 1 7 Original Article Emerging evidence
More informationAsbestos Disease: An Overview for Clinicians Asbestos Exposure
Asbestos Asbestos Disease: An Overview for Clinicians Asbestos Exposure Asbestos: A health hazard Exposure to asbestos was a major occupational health hazard in the United States. The first large-scale
More information- Compensation issues
Charité- Universitätsmedizin Berlin Institut für Arbeitsmedizin Prof. Dr. med. X. Baur Prevention, recognition and compensation of asbestosinduced diseases (AD) - Which diseases are asbestos-related? -
More informationMalignant Mesothelioma Among Employees of a Connecticut Factory that Manufactured Friction Materials Using Chrysotile Asbestos
Ann. Occup. Hyg., Vol. 54, No. 6, pp. 692 696, 2010 Ó The Author 2010. Published by Oxford University Press on behalf of the British Occupational Hygiene Society doi:10.1093/annhyg/meq046 Malignant Mesothelioma
More informationNISG Asbestos. Caroline Kirton
NISG Asbestos Caroline Kirton 1 The Control of Asbestos Regulations 2012, Regulation 10 requires every employer to ensure that adequate information, instruction and training is given to their employees
More informationPATTERNS OF MORTALITY IN ASBESTOS FACTORY WORKERS IN LONDON*
PATTERNS OF MORTALITY IN ASBESTOS FACTORY WORKERS IN LONDON* M. L. Newhouse TUC Centenary Institute of Occupational Health London School of Hygiene and Tropical Medicine London WCIE 7HT. England G. Berry
More informationMesothelioma: Questions and Answers
CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Mesothelioma: Questions
More informationUpdate of the scientific evidence on asbestos and cancer. Kurt Straif, MD MPH PhD. The IARC Monographs
Update of the scientific evidence on asbestos and cancer Kurt Straif, MD MPH PhD International Agency for Research on Cancer Lyon, France World Health Organisation Asturias, 17 March 2011 The IARC Monographs
More informationEstimation of the Number of Lung Cancer Cases Attributable to Asbestos Exposure
Estimation of the Number of Lung Cancer Cases Attributable to Asbestos Exposure BC Asbestos Statistics Approximately 55,000 BC men and women exposed in 1971 in high exposed industries Significant exposure
More informationAsbestos related cancers
New cancer cases 1954-215 in Finland, Men Pukkala et al. 26 Asbestos related cancers Panu Oksa, MD, docent Course on asbestos-related diseases Tartu 4-5.12.26 Asbestos related cancer / FIOH / PO / 1.1.27
More informationAsbestos Presence in a Factory that Produced Asbestos-Containing Products
Asbestos Presence in a Factory that Produced Asbestos-Containing Products Hana Fajkovi Department of Geology, Faculty of Science, University of Zagreb, Horvatovac 95, 10000 Zagreb, Croatia, e-mail: (hanaf@geol.pmf.hr)
More informationAsbestos in the Home MISAWA AB, JAPAN
Asbestos in the Home MISAWA AB, JAPAN Asbestos Awareness OCCUPANT ACKNOWLEDGEMENT OF INFORMATION SIGNATURE UNIT NUMBER DATE Prepared by: 35 CES/CEV If you have further question about location of asbestos
More informationBE.104 Spring Evaluating Environmental Causes of Mesothelioma J. L. Sherley
BE.104 Spring Evaluating Environmental Causes of Mesothelioma J. L. Sherley Outline: 1) Toxicological mechanisms and causation evaluations 2) An environetics case: Asbestos and Mesothelioma Toxicological
More informationDefending the Rest Basics on Lung Cancer, Other Cancers and Asbestosis: Review of the B-Read and Pulmonary Function Testing
Defending the Rest Basics on Lung Cancer, Other Cancers and Asbestosis: Review of the B-Read and Pulmonary Function Testing ASBESTOSIS November 2013 Bruce T. Bishop Lucy L. Brandon Willcox & Savage 440
More informationHow To Determine The Risk Of Mesothelioma In Brake Workers
1 Risk Anal. 2004 Jun;24(3):547-52. Related Articles, Links Mesothelioma among brake mechanics: an expanded analysis of a casecontrol study. Hessel PA, Teta MJ, Goodman M, Lau E. Exponent, Wood Dale, IL
More informationScientific Update on Safe Use of Asbestos. Robert P. Nolan, PhD International Environmental Research Foundation New York, New York www.ierfinc.
Scientific Update on Safe Use of Asbestos Robert P. Nolan, PhD International Environmental Research Foundation New York, New York www.ierfinc.org When We Talk about Asbestos What Do We Mean? Anthophyllite
More informationEFFECT OF CHILDREN'S AGE AND LIFE EXPECTATION ON MESOTHELIOMA RISK 1
EFFECT OF CHILDREN'S AGE AND LIFE EXPECTATION ON MESOTHELIOMA RISK 1 Robin Howie 2, Robin Howie Associates, Edinburgh It is generally accepted that the major risk from "low" level exposures to asbestos
More informationPlaintiffs Experts Latest Pathological Theories
Plaintiffs Experts Latest Pathological Theories Kurt B. Gerstner Campbell Campbell Edwards & Conroy, P.C. One Constitution Center Boston, MA 02129 (617) 241-3086 kgerstner@campbell-trial-lawyers.com Kurt
More informationASBESTOS. Know what it is and how you can protect yourself. environmental affairs Department: Environmental Affairs REPUBLIC OF SOUTH AFRICA
ASBESTOS Know what it is and how you can protect yourself environmental affairs Department: Environmental Affairs REPUBLIC OF SOUTH AFRICA 1 What is asbestos? The term asbestos designates a group of naturally
More informationASBESTOS AWARENESS. For workers and building occupants
ASBESTOS AWARENESS For workers and building occupants Asbestos Awareness Asbestos is a serious health hazard commonly found in our environment today. This module is designed to provide an overview of asbestos
More informationSir William Osler: Listen to the patient; the patient tells you everything.
Sir William Osler: Listen to the patient; the patient tells you everything. Jean-Martin Charcot: The patient is a liar. Epidemiology of Mesothelioma Jeffrey H. Mandel, MD, MPH Division of Environmental
More informationASBESTOS FIBRES IN THE LUNGS OF CHRYSOTILE MINERS AND MILLERS A PRELIMINARY REPORT
Ann. occup. llyy.. Vol.. Mos. I 4. pp. 4-4. 98. Primed in Great Bnlain. Inhaled Panicles V 0003 4878/8,004-OSO3.00/O Pergamon Press Lid. (' 98 British Occupational Hygiene Society. ASBESTOS FIBRES IN THE
More informationAsbestos Trends Worldwide, with Richard Lemen
Asbestos Trends Worldwide, with Richard Lemen Ashley Ahearn Views and opinions expressed in these podcasts are those of the interview subjects and do not necessarily reflect the views, opinions, or policies
More informationMesothelioma Incidence and Community Asbestos Exposure
ENVIRONMENTAL RESEARCH 75, 34 40 (1997) ARTICLE NO. ER973770 Mesothelioma Incidence and Community Asbestos Exposure Michael Berry Consumer and Environmental Health Services, New Jersey Department of Health
More informationAsbestos and Mesothelioma in Thailand
MD, DScMed, FRCP, FRACP, hon. FACP Emeritus Professor and Fellow of the Academy of Science, the Royal Institute of Thailand Abstract Chrysotile, a serpentile asbestos, has been used in a number of Thai
More informationHow To Prevent Asbestos Related Diseases
BD5.3 Report of Working Groups Elimination of Asbestos-related Diseases ICOH 2012 March 18, 2012 Cancun Report of WG Elimination of Asbestos-related Diseases Dr. Sherson mail to ICOH President of 7 December
More informationEpidemiology of Malignant Mesothelioma An Outline
Commentary Ann. Occup. Hyg., Vol. 54, No. 8, pp. 851 857, 2010 Ó The Author 2010. Published by Oxford University Press on behalf of the British Occupational Hygiene Society doi:10.1093/annhyg/meq076 Epidemiology
More informationFrequently asked questions
Frequently asked questions Asbestos investigation An investigation into asbestos-related health concerns has found that there is no evidence of elevated asbestos-related health risk to residents who have
More informationAsbestos. General information
Asbestos General information Key Points Fire Non flammable and non combustible under normal conditions Chemically inert under normal conditions. Resistant to most solvents, acids and alkalis In the event
More informationLung cancer and asbestos
Lung cancer and asbestos Bureau Veritas Training Bill Sanderson For the benefit of business and people To begin with.. There are known knowns, that is there are things we know that we know. There are known
More informationNonoccupational Exposure to Chrysotile Asbestos and the Risk of Lung Cancer
Coirespon... : 999-100 Page 1 of 10 http ://www.nejm.org/content/1998/0339/0014/0999.asp 10/19/1999 NE3M Home ISeareh I Log On to Full Text -._ Table of Contents I Previous Article I Next Article The New
More informationSurvey on the Mortality from Malignant Tumors of Female Asbestos Spinning Workers
Table of Contents WS-E-12 Xing Zhang Survey on the Mortality from Malignant Tumors of Female Asbestos Spinning Workers Xing Zhang 1, Tong-da Sun 2, Nan-feng Shi 2, Li-qiu Zhu 1, Kenji Morinaga 3 1 Institute
More informationAsbestos Awareness at the University of Toronto
Asbestos Awareness at the University of Toronto What is Asbestos? Asbestos is a general term given to a group of naturally occurring mineral silicates that are made up of long thin fibres. These fibrous
More informationAsbestos Diseases. What Is Asbestos?
1 Asbestos Diseases What Is Asbestos? Asbestos is a term applied to a group of minerals formed into rock and mined in a similar way to coal. In this form, asbestos is made up of strong, fine and flexible
More informationNaturally Occurring Asbestos (NOA) General Overview
Naturally Occurring Asbestos (NOA) General Overview Lee R. Shull PhD Health, Ecology and Risk Practice MWH Global Sacramento, CA CASH NOA Workshop January 24, 2006 Presentation Outline Brief background
More informationMesothelioma among shipyard workers in Monfalcone, Italy
Original Article Mesothelioma among shipyard workers in Monfalcone, Italy Abstract Background: The high mesothelioma incidence in Monfalcone, Italy, is mainly attributable to shipbuilding activity. Mesothelioma
More informationAsbestos Related Diseases
Asbestos Related Diseases Asbestosis Mesothelioma Lung Cancer Pleural Disease Asbestosis and Mesothelioma (LUNG CANCER) Support Group 1800 017 758 www.amsg.com.au ii Helping you and your family through
More informationBY THE NUMBERS: THE FUTURE OF MESOTHELIOMA IN AMERICA
BY THE NUMBERS: THE FUTURE OF MESOTHELIOMA IN AMERICA 1 CUTTING-EDGE ISSUES IN ASBESTOS LITIGATION CONFERENCE Scott Masterson Lewis, Brisbois, Bisgaard & Smith, LLP 1180 Peachtree Street, NE, Suite 2900
More informationFuture Trends of Mesothelioma Mortality in Japan Based on a Risk Function
Industrial Health 2012, 50, 197 204 Original Article Future Trends of Mesothelioma Mortality in Japan Based on a Risk Function Tomoya MYOJIN 1, Kenichi AZUMA 2 *, Jiro OKUMURA 2 and Iwao UCHIYAMA 3 1 Department
More informationMalignant Mesothelioma Versus Metastatic Carcinoma of the Pleura: A CT Challenge
Iran J Radiol. 2016 January; 13(1): e10949. Published online 2015 November 14. CHEST IMAGING DOI: 10.5812/iranjradiol.10949 Research Article Malignant Mesothelioma Versus Metastatic Carcinoma of the Pleura:
More informationThe Management of Asbestos at the University of Manitoba
The Management of Asbestos at the University of Manitoba WHAT IS ASBESTOS? Asbestos is a name given to a group of minerals which occur naturally as masses of long silky fibres. Asbestos is known for its
More informationWhat is Asbestos? Asbestos was also used in household items, such as: oven gloves ironing board pads simmer mats for stoves fire blankets.
All About Asbestos Read this booklet to learn more about: identifying asbestos-containing material in your home the health risks of asbestos what you can do about asbestos. What is Asbestos? Asbestos is
More informationAsbestos Diseases Uncovered
Asbestos Diseases Uncovered Your complete download & keep guide to asbestos-related diseases. Their symptoms, causes and potential compensation payable Contents What is Asbestos? What diseases are caused
More informationProducing Analytical Data, Microscopy and Analytical Procedures
1 The Role of Fiber Analysis in Asbestos Induced Lung Disease: TEM vs. SEM. Is There Controversy Elizabeth N. Pavlisko, M.D., Department of Pathology, Duke University Medical Center I. Introduction to
More informationFrequently Asked Questions
This fact sheet was written by the Agency for Toxic Substances and Disease Registry (ATSDR), a federal public health agency. ATSDR s mission is to serve the public by using the best science, taking responsive
More informationby Lee S. Newman, M.D., and Cecile S. Rose, M.D., M.P.H.
OCCUPATIONAL ASBESTOSIS AND RELATED DISEASES by Lee S. Newman, M.D., and Cecile S. Rose, M.D., M.P.H. A 63-year-old man consulted an internist complaining of dyspnea on exertion. He reported the following:
More informationAsbestos Related Diseases. Asbestosis Mesothelioma Lung Cancer Pleural Disease. connecting raising awareness supporting advocating
Asbestos Related Diseases Asbestosis Mesothelioma Lung Cancer Pleural Disease connecting raising awareness supporting advocating 1800 017 758 www.asbestosassociation.com.au Asbestos lagging was widely
More informationA Cross-Sectional Study of Asbestos- Related Morbidity and Mortality in Vermonters Residing Near an Asbestos Mine November 3, 2008
A Cross-Sectional Study of Asbestos- Related Morbidity and Mortality in Vermonters Residing Near an Asbestos Mine 108 Cherry Street, PO Box 70 Burlington, VT 05402 802.863.7200 healthvermont.gov A Cross-Sectional
More informationMesothelioma. 1995-2013, The Patient Education Institute, Inc. www.x-plain.com ocft0101 Last reviewed: 03/21/2013 1
Mesothelioma Introduction Mesothelioma is a type of cancer. It starts in the tissue that lines your lungs, stomach, heart, and other organs. This tissue is called mesothelium. Most people who get this
More informationJune 20, 2002. 2002.06.20: Wagner Testimony on Workplace Exposure to Asbestos. This is an archive page. The links are no longer being updated.
Page 1 of 6 skip navigational links This is an archive page. The links are no longer being updated. Statement by Gregory R. Wagner, M.D. Director, Division of Respiratory Disease Studies National Institute
More informationMESOTHELIOMA IN AUSTRALIA INCIDENCE 1982 TO 2008 MORTALITY 1997 TO 2007
MESOTHELIOMA IN AUSTRALIA INCIDENCE 1982 TO 28 MORTALITY 1997 TO 27 August 212 Safe Work Australia Mesothelioma in Australia Incidence 1982 to 28 Deaths 1997 to 27 August 212 Acknowledgement Data on the
More informationAll You Need to Know About Asbestos
All About Asbestos Read this booklet to learn more about: identifying asbestos-containing material in you home the health risks of asbestos what you can do about asbestos. What Is Asbestos? Asbestos is
More informationNon-Occupational Asbestos Exposure:
MPHP 429 Goodman 1 Non-Occupational Asbestos Exposure: Asbestosis, Mesothelioma and Lung Cancer Bianca Goodman Introduction to Environmental Health April 8, 2010 Bianca Goodman Intro to Environmental Health
More informationClinical cases in Malignant Pleural Mesothelioma: Adherence to the ESMO Clinical Practice Guidelines
Clinical cases in Malignant Pleural Mesothelioma: Adherence to the ESMO Clinical Practice Guidelines Wieneke Buikhuisen The Netherlands Cancer Institute Amsterdam The Netherlands Case (1) Male, 56 year
More informationAsbestos - Frequently Asked Questions
Asbestos - Frequently Asked Questions 1. What is asbestos? Asbestos is the name given to a group of fibrous minerals which occur naturally in the earth. These are grouped into two mineral types known as
More informationASBESTOS AWARENESS. Environmental Health And Safety. www.uoguelph.ca/ehs MAINTENANCE CONTRACTORS
ASBESTOS AWARENESS MAINTENANCE CONTRACTORS Environmental Health And Safety www.uoguelph.ca/ehs March 2007 ASBESTOS AWARENESS AT THE UNIVERSITY OF GUELPH What is Asbestos? The term asbestos refers to a
More informationReview of Eliminating occupational cancer in Europe and globally by J. Takala
Review of Eliminating occupational cancer in Europe and globally by J. Takala There primary concerns of this manuscript are outlined below. More detail discussion of these points is presented on the following
More informationMesothelioma in Australia: Incidence (1982 to 2013) and Mortality (1997 to 2012)
Mesothelioma in Australia: Incidence (1982 to 213) and Mortality (1997 to 212) 215 Disclaimer The information provided in this document can only assist you in the most general way. This document does not
More informationThe Trend in Airborne Asbestos Concentrations at Plants Manufacturing Asbestos-Containing Products in Japan
Industrial Health 2001, 39, 127 131 Original Article The Trend in Airborne Asbestos Concentrations at Plants Manufacturing Asbestos-Containing Products in Japan Koji YOSHIZUMI 1 *, Hajime HORI 2, Toshihiko
More informationASBESTOS AWARENESS TRAINING. For workers and building occupants
University of Nevada, Reno ASBESTOS AWARENESS TRAINING PROGRAM For workers and building occupants John A Braun, CSP Asbestos Awareness OSHA Standards for Asbestos are: 29 CFR 1910.1001 applies to all occupational
More informationPrimary reason asbestos is used, is its special resistance to heat. Asbestos fibers are also virtually indestructible.
ASBESTOS AWARENESS Asbestos Awareness Asbestos is a serious health hazard commonly found in our environment today. This module is designed to provide initial education of asbestos and its associated hazards.
More informationIWU PHYSICAL PLANT SAFETY PROGRAM. Toxic and Hazardous Substances, Title 29 Code of Federal Regulations (CFR) Part 1910.1001, Subpart Z Asbestos
STANDARDS Toxic and Hazardous Substances, Title 29 Code of Federal Regulations (CFR) Part 1910.1001, Subpart Z Asbestos 1. INTRODUCTION IWU has a responsibility to provide a safe environment for students,
More informationNaturally-Occurring Asbestos General Information
Naturally-Occurring Asbestos Information Asbestos is a term used for several types of naturally-occurring fibrous minerals found in many parts of California. The most common type of asbestos is chrysotile,
More informationAsbestos and Mesothelioma in Ontario
Asbestos and Mesothelioma in Ontario May 29, 2010 CARWH Conference: Worker Health in a Changing world of work Loraine Marrett, PhD Outline Part I: Asbestos & its uses Part II: Asbestos & cancer Part III:
More informationAsbestos exposure during Canterbury rebuild unlikely to cause significant health problems for house occupants report finds
News release from the Royal Society of New Zealand and the Office of the Prime Minister s Chief Science Advisor 15 April 2015 Asbestos exposure during Canterbury rebuild unlikely to cause significant health
More informationEnvironmental Asbestos Exposure in Poland
Reference Centre for Asbestos Exposure &Health Risk Assessment Material partly was presented on: European Asbestos Conference: Policy, Status & Human Rights European Parliament, Brussels, 22-23 September
More informationMalignant Pleural Mesothelioma in Parts of Japan in Relationship to Asbestos Exposure
Industrial Health 2004, 42, 435 439 Original Article Malignant Pleural Mesothelioma in Parts of Japan in Relationship to Asbestos Exposure Takumi KISHIMOTO 1 *, Shinji OZAKI 1, Katsuya KATO 1, Hideyuki
More informationDisease/Illness GUIDE TO ASBESTOS LUNG CANCER. What Is Asbestos Lung Cancer? www.simpsonmillar.co.uk Telephone 0844 858 3200
GUIDE TO ASBESTOS LUNG CANCER What Is Asbestos Lung Cancer? Like tobacco smoking, exposure to asbestos can result in the development of lung cancer. Similarly, the risk of developing asbestos induced lung
More informationPREDICTION OF CANCER MORTALITY BY EVALUATION OF ASBESTOS FIBERS CONCENTRATIONS IN AN ASBESTOS-CEMENT PRODUCTS FACTORY
Iran. J. Environ. Health. Sci. Eng., 21, Vol. 7, No. 2, pp. 165-172 PREDICTION OF CANCER MORTALITY BY EVALUATION OF ASBESTOS FIBERS CONCENTRATIONS IN AN ASBESTOS-CEMENT PRODUCTS FACTORY 1 M. J. Jafari,
More informationAsbestos-related Occupational Lung Diseases in NSW, Australia and Potential Exposure of the General Population
Industrial Health 2008, 46, 535 540 Review Article Asbestos-related Occupational Lung Diseases in NSW, Australia and Potential Exposure of the General Population Eun-Kee PARK 1, Kirsty M. HANNAFORD-TURNER
More informationAsbestos Awareness. What is Asbestos?
Asbestos Awareness Asbestos is a serious health hazard commonly found in our environment today. This module is designed to provide an overview of asbestos and its associated hazards. It is important for
More informationAsbestos and the diseases it causes
Asbestos and the diseases it causes October 2013 Liz Darlison Mesothelioma UK University Hospitals of Leicester Contents What is asbestos Why is it such an issue in the UK Disease Statistics Asbestos Related
More informationThe Carcinogenicity of Chrysotile Asbestos A Review
Industrial Health 2001, 39, 57 64 Review Article The Carcinogenicity of Chrysotile Asbestos A Review William J. NICHOLSON Mount Sinai School of Medicine, NY, NY, USA Received December 23, 2000 and accepted
More informationMESOTHELIOMA IN AUSTRALIA INCIDENCE 1982 TO 2009 MORTALITY 1997 TO 2011
MESOTHELIOMA IN AUSTRALIA INCIDENCE 1982 TO 29 MORTALITY 1997 TO 211 OCTOBER 213 Safe Work Australia Mesothelioma in Australia Incidence 1982 to 29 Mortality 1997 to 211 OCTOBER 213 Acknowledgement Disclaimer
More information