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1 m Product Information Dossier (PI) Product PD240 JUVELEVEN solution peptide Date May 2014 Revision 4
2 Contents PRODUCT INFORMATION Trade Name & Code 3 Manufacturer 3 INCI name 3 Composition 4 Additional information on ingredients 4 Specifications 5 Storage 6 Shelf life 6 Impurities 6 Regulatory status 6 REACH 7 Statements 7 MANUFACTURING FLOWCHART 9 SAFETY 10 ADDITIONAL INFORMATION 11 2
3 Product Information Trade Name & Code TRADE NAME CODE PD240 Manufacturer LIPOTEC S.A.U. C/ ISAAC PERAL 17, POL. IND. CAMÍ RAL GAVÀ (BARCELONA) SPAIN INCI name BUTYLENE GLYCOL, WATER (AQUA), ACETYL HEAPEPTIDE-51 AMIDE 3
4 Composition INGREDIENT % CAS EINECS Butylene Glycol Up to 100% Water (Aqua) % Acetyl Hexapeptide-51 Amide % - - Additional information on ingredients INGREDIENT Butylene Glycol Water (Aqua) Acetyl Hexapeptide-51 Amide FUNCTION Solvent Solvent Active Ingredient vegetal origin: (none) biosynthetic origin: (none) animal origin: (none) synthetic origin: Butylene Glycol, Acetyl Hexapeptide-51 Amide; mineral origin: Water (Aqua). 4
5 Specifications Analytical Data TEST SPECIFICATION METHOD Physical appearance Transparent solution CC B6 Colour Colourless CC B6 Specific gravity (g/ml) CC B3 ph N.A. Viscosity (cps) N.A. Particle size (mm) N.A. Refractive index CC B4 Dry residue (%) N.A. Identification (HPLC) Similar retention CC B19 time as in-house ref. standard Microbiological Data TEST SPECIFICATION METHOD TOTAL AEROBIC MICROBIAL COUNT < 100 cfu/g Current U.S.P. version TOTAL YEAST AND MOULD COUNT < 10 cfu/g Current U.S.P. version SPECIFIC MICROORGANISMS: Escherichia coli ABSENCE/0.5 g Current U.S.P. version Pseudomonas aeruginosa ABSENCE/g Current U.S.P. version Staphylococcus aureus ABSENCE/g Current U.S.P. version Candida albicans ABSENCE/g Current U.S.P. version Remarks Contains 0.05% JUVELEVEN peptide. 5
6 Storage should be stored in a clean, cool and dark place. Shelf life If stored as recommended, shelf life is 18 months. Impurities ANALYSIS AVAILABLE EPECTED RESULT/COMMENTS Heavy metals YES - Heavy Metals < 10 ppm Arsenic < 0.5 ppm Diethylene Glycol NO NO Not expected based on product knowledge Other impurities - Regulatory status Information on the regulatory status of is given to the best of our knowledge in the chart below: REGION STATUS European Union In accordance with Regulation 1223/2009 on cosmetic products U.S.A. No ingredient restrictions known on cosmetic regulations Japan No ingredient restrictions known on cosmetic regulations Brazil In accordance with Resolution RDC No.215 of July 25, 2005 Australia All ingredients listed in AICS 1 schedule Exception: Acetyl Hexapeptide-51 Amide* No ingredients listed in SUSMP 2 1 AICS: Australian Inventory of Chemical Substances 2 SUSMP: Standard for the Uniform Scheduling of Medicines and Poisons *The obligation to notify to NICNAS applies only to import volumes over 10 kg of substance/year 6
7 REACH INGREDIENT STATUS COMMENTS Butylene Glycol Pre-registered by supplier - Water (Aqua) Exempt (Annex IV/V) - Acetyl Hexapeptide-51 Amide Exempt (< 1 Tonne/year) - Statements STATEMENT YES/NO COMMENTS Does the product contain any genetically modified ingredient? Does the product contain as an ingredient any of the 26 substances listed in Annex III of Cosmetics Regulation (EC) 1223/2009 and identified by the SCCNFP as likely to cause allergenic reactions? Has the product undergone animal tests sponsored by Lipotec S.A.U.? Is the product expected to contain any pesticide? Does the product contain as an ingredient any substance classified as CMR (Carcinogenicity, Germ Cell Mutagenicity and Reproductive Toxicity) from classes 1A, 1B or 2 in accordance with CLP Regulation 1272/2008 and its subsequent amendments? Does the product contain, as an ingredient, any of the following glycol ethers? EDGME (CAS nº ) DEDGME (CAS nº ) TEDGME (CAS nº ) EGBE (CAS nº ) DEGBE (CAS nº ) DEGEE (CAS nº ) 7
8 Does the product contain, as an ingredient, any phthalate? Is the product expected to contain any nanomaterial meaning an insoluble or biopersistant and intentionally manufactured material with one or more external dimensions, or an internal structure, on the scale from 1 to 100 nm, as defined in Regulation (EC) No 1223/2009 on cosmetic products? Is the product expected to contain gluten? Does the product contain any ingredient that, according to the information provided by our suppliers, falls under the definition of Volatile Organic Compound (VOC) as described in Directive 2004/42/CE? Is there risk of contamination with Bovine Spongiform Encephalopathy (BSE) through the use of this product? Is the product expected to contain, as an ingredient, any dioxin? * - Does the product contain ethanol as an ingredient? Is the product suitable for vegetarians? YES - Is the product suitable for vegans? YES - *According to the information provided by our suppliers, the following ingredients fall under the definition of Volatile Organic Compound (VOC) as described in Directive 2004/42/CE: Butylene Glycol. Please, note that these ingredients are not listed in Annex I of the Swiss Ordinance
9 Manufacturing flowchart The product is manufactured according to the manufacturing standard protocol: ACTIVE INGREDIENT SOLVENT SOLVENT check product specifications PD240 9
10 Safety The toxicological profile of JUVELEVEN TM peptide for cosmetic purposes was assessed in vitro. A full toxicological report and a summary of all the safety tests performed are available on request. IN VITRO TESTS Cytotoxicity test on human epidermal keratinocytes JUVELEVEN peptide showed no significant signs of cytotoxicity at the concentrations assayed. Cytotoxicity test on 3T3 fibroblasts JUVELEVEN peptide proved not to have cytotoxic effects at the tested concentration. Ocular Irritation (HET-CAM test) According to the results of the HET-CAM test, JUVELEVEN peptide showed no ocular irritation at the tested concentration. NRU Phototoxicity test JUVELEVEN peptide showed no signs of phototoxicity at the concentrations assayed. Bacterial reverse mutation test (Ames test) JUVELEVEN peptide produced no mutagenic activity in any of the bacterial strains tested. IN VIVO TESTS Skin sensitisation and cutaneous compatibility test A HRIPT (Human Repeated Insult Patch Test) was performed on 100 volunteers aged 18 to 70. JUVELEVEN peptide 0.1% induced neither irritation nor any allergic reaction. 10
11 Additional Information DOCUMENTATION AVAILABLE NOT AVAILABLE Technical Report Brochure Complete Tox Toxicity Summary Stability Report Material Safety Data Sheet JUVELEVEN peptide solution is owned by the Lubrizol Corporation Note: Graphs and photographs of efficacy tests are available for customer use provided that the final product contains the same concentration of active as the formulations in our tests. Customers must request written permission for use of the graphic material and/or ingredient tradenames to Lipotec. Customers are responsible for compliance with local and international advertising regulations. The specific situation of the trademark in each country may vary and we recommend that you contact us for updated information. Disclaimer: While the claims and supporting data provided in this publication are believed to be reliable and they are presented free and for guidance only, there are no warranties of any kind made as to its accuracy, suitability for particular applications, how the product(s) will perform in combination with other substance or in the user s process or the results obtained. All expressed and implied warranties are disclaimed. Lipotec MAKES NO WARRANTIES, EPRESS OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE. The recipient is solely responsible for ensuring that products marketed to consumers comply with all relevant laws and regulations and assumes all risk and liability of any use or handling of any materials. Recipient of this publication agrees to indemnify and hold harmless each entity of the Lipotec organization for any and all actions arising from recipient s use of any claims or information in this publication, including, but not limited to, use in advertising and finished product label claims, and not present this publication as evidence of finished product claim substantiation to any regulatory authority. Nothing contained herein is to be considered as permission, recommendation, nor as an inducement to practice any patented invention without permission of the patent owner The Lubrizol Corporation. All Rights Reserved. 11
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