Focusing on differentiated medicines
|
|
|
- Louise Washington
- 9 years ago
- Views:
Transcription
1 Roche Phamaceuticals Focusing on diffeentiated medicines D. Guido Magni Head of Global Medical Science Lehman Bothes Global Healthcae Confeence, Miami, 26 1 This pesentation contains cetain fowad-looking statements. These fowad-looking statements may be identified by wods such as believes, expects, anticipates, pojects, intends, should, seeks, estimates, futue o simila expessions o by discussion of stategy, goals, plans o intentions. Vaious factos may cause actual esults to diffe mateially in the futue fom those eflected in fowad-looking statements contained in this pesentation among othes: 1. Picing and poduct initiatives of competitos; 2. Legislative and egulatoy developments and economic conditions; 3. Delay o inability in obtaining egulatoy appovals o binging poducts to maket; 4. Fluctuations in cuency exchange ates and geneal financial maket conditions; 5. Uncetainties in the discovey, development o maketing of new poducts o new uses of existing poducts; 6. Inceased govenment picing pessues; 7. Inteuptions in poduction; 8. Loss of o inability to obtain adequate potection fo intellectual popety ights; 9. Litigation; 1. Loss of key executives o othe employees; and Advese publicity o news coveage Fo maketed poducts discussed in this pesentation, please see full pescibing infomation on ou website 2
2 R&D pefomance in 25 Stategy and outlook 3 25: An outstanding yea Phama oganic gowth fou times faste than wold maket top ten poducts +32 %, top twenty poducts +31 % Successful launch of seven new poducts/indications Outstanding clinical data in oncology Fou phase tials fo CERA in enal anemia successfully completed Built the base fo enty into a new theapeutic fanchise of Autoimmune diseases 4
3 Ou objectives in R&D Deliveing clinically diffeentiated medicines Ceate the best medicine by Pioneeing 1 st -in-class theapy Ceating best-in-class in aeas of established mechanisms Maximizing poduct lifecycles though innovative development 5 25: Successful appovals and stong clinical news-flow Building the base fo futue gowth Majo ganted appovals -mcrceu Pegasys - HBV EU and US Pegasys - HCV/HIV coinfection EU and US Xenical - adolescent obesity EU Xenical - pevention of T2D EU and US Boniva - osteopoosis (oal monthly) EU and US Boniva - osteopoosis (iv) US* - adj CC EU and US Taceva - NSCLC EU Taceva - panceatic Ca US Actema - Castleman s disease Jp * Jan. 6, CHMP positive opinion EU Completed phase tials - NSCLC (E4599) - mbc (E21) Heceptin adj. BC (NSABP / NCCTG) Heceptin adj. BC (HERA) Heceptin adj. BC (BCIRG 6) panceatic Ca maintenance inhl (EORTC2891) RA (REFLEX) Actema RA (Japanese tial) Pegasys/Copegus HCV (Japanese tial) CERA enal anemia (BA16739, BA1674, BA17283, BA17284) Lucentis AMD (MARINA) All appovals obtained as planned (16) All phase tials met pimay end-points (15) 6
4 Making a diffeence fo patients - and boding well fo futue gowth Poduct Heceptin Taceva Actema Indication (clinical tial) NSCLC 1st line (E4599) mbc 1st line (E21) mcrc 2nd-line (E32) BC adjuvant (NSABP B-31/N9831) BC adjuvant (HERA) BC adjuvant (BCIRG 6) inhl elapsed maintenance (GSLG) inhl elapsed maintenance (EORTC 2891) Panceatic cance 1st line (PA3) Panceatic cance 1st line (CR UK) Rheumatoid athitis (Japan) Rheumatoid athitis TNF nonesp. (REFLEX) Benefit 23% eduction in isk of death 5% eduction in isk of cance pogession 24% eduction in isk of death 52% eduction in isk of disease ecuence 46% eduction in isk of disease ecuence 51% eduction in isk of disease ecuence >17 months polongation of PFS 5% eduction in isk of death 19% eduction in isk of death 2% eduction in isk of death ACR2, 5 and 7 of 89%, 7% and 47% ACR2, 5 and 7 of 51%, 27% and 12% 7 An industy leading late stage pipeline Again stengthened Phase / filed pojects * 41 New Initiatives in Autoimmune Diseases CellCept in LN, MG in RA DMARD nonesp. New Initiatives in Cance Taceva in NSCLC in postate, ovaian, CRC, BC Heceptin in gastic Ca Epogin in cance anemia end '4 appoved discontinued new enties end '5 * Including thee pojects peviously combined and now listed as seven single indications 8
5 An outstanding success ate in R&D Measues taken to impove chances fo success Roche Rx Phase success ate in % 1 8 Additional Indications New M olecula Entities '96-' '97-'1 '98-'2 '99-'3 '-'4 '1-'5 1 Data fo Additional Indications only available fo cohot 1-5 Success ate = 1- teminations / (teminations + appovals) 9 R&D pefomance in 25 Stategy and outlook 1
6 Emeging potfolios in vaious theapeutic aeas Oncology Heceptin Taceva CERA Bondonat Omnitag R1492 epothilone D CAL Chugai DMXAA Antisoma 1 phase I compounds FY 25 - Autoimmune Mabthea Actema CellCept R153 p38 kinase inh. R1594 hum anti CD-2 4 phase I compounds On hand Metabolic R144 GK act. R1438 DPP IV inh. R483 Insulin Sensit. R1658 CETP inh. GLP-1 Ipsen 3 phase I compounds Pomising late stage Neuology 3 phase I compounds 4 phase compounds Emeging mid-tem Ealy stage 11 : A unique development appoach All main cance types, including ealy intevention, in paallel Phase indication mcrc 1st line mcrc 1st line ext. CC adjuvant NSCLC 1st line non-squamous NSCLC 1st line maint. combo Taceva NSCLC 2nd line combo Taceva NSCLC adjuvant mbc 1st line mbc 1st line combo extension BC adjuvant RCC 1st line Panceatic Ca 1st line Ovaian Ca Postate Ca Status Launched US/EU Recuitment completed, EU filing '6 Recuitment ongoing, EU filing post '9 Data pesented, filing '6 Stated Q4 5, EU filing post '9 Recuitment ongoing, EU filing '8 To stat soon Data pesented, filing '6 Stated Q4 5, EU filing '8 Pilot ongoing Recuitment completed, EU filing '7 Recuitment ongoing, EU filing '8 Recuitment ongoing, EU filing post '9 Recuitment ongoing, EU filing post '9 3 d line 2 nd line 1 st line Adjuvant NSCLC CRC Establish as a backbone theapy fo all majo tumos BC 12
7 25: Roche in Rheumatoid Athitis The fist poducts in the autoimmune fanchise AI diseases RA CHF bn Sales to teat RA 1 Biologic agents Conventional DMARDs Phase I R1541 (IBD) R1295 (RA) R3421 (AI) BR3-FC (RA) GNE Phase II R153 (RA) R1594 (RA) (RRMS) GNE (LN) GNE Anti-TNF inadequate espondes (REFLEX) - filed in US and EU DMARD inadequate espondes - phase initiated (3 tials), filing in 27 Actema Phase completed in Japan, on tack (5 tials) in RoW Japanese filing in 26, filing in US and EU in 27 (RA DMARD) Actema (RA) Actema (sjia) CellCept (LN) CellCept (MG) Phase (PPMS) GNE (ANCA av) GNE (SLE) GNE Filed (RA TNF) 1 Souce : Decision Resouces Mach 25, US/Top 5 EU/Japan 13 efficacy in RA (REFLEX) ACR esponses at 6 months 1 Mean change in Shap-Genant eosion scoe % p atients Placebo + MTX (n=21) ACR2 ACR5 ACR7 P <.1 51 P <.1 27 Rituximab 2x1mg + MTX (n=298) P <.1 12 Mean Change in Shap-Genant (Eosion Scoe) Weeks Placebo (n=21) Rituximab 2x1mg (n=298) Robustness Analysis : All 24 week data included, missing values imputed with LOCF (no change) significantly impoves ACR esponses 14
8 in RA Conclusions of 6-month pimay analyses in combination was associated with a highly significant incease in ACR2 esponse ate ove placebo + MTX All seconday and exploatoy endpoints (DAS, EULAR, ACR coe set, FACIT-F) wee highly significantly impoved ove placebo Efficacy demonstated in RF-negative patients Suggestion of effects on joint damage at 24 weeks Well toleated Data filed in US and EU 15 Actema monotheapy in RA (Japanese p) Efficacy ACR esponses at 52 weeks Radiogaphic data (mean scoes) % of patients p < Actema 8 mg/kg Contol Change fom baseline p < Actema 8 mg/kg Contol ACR 2 ACR 5 ACR 7 TSS JSN ES TSS: Total Shap Scoe; JSN: Joint Space Naowing; ES: Eosion Scoe Significantly impoved ACR esponses and significantly less adiogaphic pogession with Actema 16
9 Actema monotheapy in RA Peliminay esults Fist tial showing supeioity of blocking IL-6 with Actema to conventional DMARDs Blocking the IL-6 ecepto with Actema leads to significant impovement in signs and symptoms and educe the pogession of joint damage Advese events ae within expectations 1 - AEs: 96% vs. 87% in Actema vs. DMARDs goup - SAEs: 19% vs. 13% in Actema vs. DMARDs goup Five phase tials in Roche teitoies ongoing 1 most fequently epoted infectious event: nasophayngitis; mild, tansient inceases in LFTs wee obseved in both goups lipid inceases wee mainly epoted in the Actema goup: mean total cholesteol levels became stable ( mg/dl) at aound the nomal uppe limit 17 Conclusions 18
10 A ich and low isk Phase pipeline Keeping the high level of commitment Filed o to file soon maintenance inhl RA TNF nonesp. Heceptin adjuvant BC Taceva panceatic Ca Femaa Beast Ca (Japan) Antevas subaach. haemo. Lucentis AMD Sigmat acute heat failue NSCLC mbc CERA enal anemia 1st line CLL adjuvant CC combo Postate Ca Taceva & NSCLC 2nd line RA DMARD failues ANCA ass. vasculitis elapsed CLL mcrc 1st line ext. ovaian Ca Heceptin gastic Ca CellCept lupus nephitis SLE Ongoing adjuvant BC mcrc 1st line combo adjuvant CC RCC mbc 1st line ext. Taceva NSCLC 1st line Heceptin mbc combo homonal Actema RA CellCept myasthenia gavis Bondonat MBP Epogin chemotheapy-induced anemia ED-71 osteopoosis mcrc 2nd line combo panceatic Ca Taceva & NSCLC maintenance Actema sjia PPMS Xolai pediatic asthma To stat soon Taceva adjuvant NSCLC adjuvant NSCLC adjuvant BC Status as of Decembe 31, Ou objectives fo 26 Anothe busy yea Filings Majo clinical data Compound R744 (CERA) CellCept Heceptin / R1658 R873 / Taceva R1594 Compound R744 (CERA) Heceptin Heceptin Phase II IIa II II Indication Renal anemia NSCLC 1st line mbc 1st line Indication Renal anemia (coection) Lupus nephitis (Induction phase) mbc combo homonal (TAnDEM) mcrc 2nd line NSCLC 1st line (AVAIL) mcrc 1st line combo extension Dyslipidemia MED NSCLC 2nd line RA mcrc 1st line combo extension Adjuvant BC mbc combo homonal mcrc 1st line combo Data Inteim baing unfoeseen events 2
11 Majo Roche managed pojected submissions ove the next yeas Phase II Phase R1558 bacteial infections R153 RA R144 type II diabetes R873 male eectile dysfunction R1594 RA (EU) R667 emphysema R744 (CERA) enal anaemia R1492 solid tumos R1273 (Omnitag) solid tumos (EU) NSCLC 1st line (EU) Actema RA / sjia adj. CC combo R1658 dyslipidemia Heceptin adj. BC (EU) Bondonat metastatic bone pain panceatic Ca (EU) NSCLC squamous (EU) mbc 1st line (EU) mcrc 2nd line combo Heceptin gastic Ca (EU) R1438 type II diabetes adj. CC (EU) Heceptin mbc homonal (EU) CellCept lupus nephitis Taceva NSCLC 1st line chemo (EU) R744 (CERA) cance anaemia postate Ca (EU) mcrc 1st line combo extension (EU) mcrc 1st line combo RA DMARD inadeq. esp. (EU) RCC (EU) Taceva+ NSCLC 2nd line (EU) mbc 1st line extension (EU) adj. BC CLL (EU) ovaian Ca (EU) Taceva+ NSCLC 1st line maint (EU) post 29 Status as of Decembe 31, 25 Unless stated othewise, submissions will occu in US and EU 21 The bottom-line Stong pipeline and pefomance ove long tem Rich late-stage pipeline with low isk Emeging ealy potfolio in vaious theapeutic aeas Oncology-fosteing maket leadeship with 5 NME with suvival benefit and additional indications Continuing deliveing fist-in-class medicines ( in cance theapy, and Actema in RA) Vaious best-in-class molecules in development (CERA in anemia, Taceva in cance theapy) Continuing maximizing the value of appoved poducts by effective life cycle management (,,, Pegasys, CellCept) Well-pepaed fo futue gowth 22
The relevance of Roche s strategy in the current market environment
Maket dynamics in the Healthcae Industy The elevance of Roche s stategy in the cuent maket envionment D. F.B. Hume, CEO Bank am Bellevue, Januay 2005 This pesentation contains cetain fowad-looking statements.
The future challenges of Healthcare
The futue challenges of Healthcae D. Eich Hunzike CFO F. Hoffmann La Roche Ltd. JPMogan Healthcae Confeence San Fancisco, Januay 12, 2005 This pesentation contains cetain fowad-looking statements. These
Roche Diagnostics Leading and creating new markets
Roche Leading and ceating new makets Heino von Pondzynski Head of Roche Goldman Sachs UK Roadshow London, May 14 th 2004 This pesentation contains cetain fowad-looking statements. These fowad-looking statements
Presentation to analysts Basel, October 14, 2004. Roche YTD Sep '04 Sales, Oct 14, 2004
Roche Thid quate 2004 Pesentation to analysts Basel, Octobe 14, 2004 2 1 This pesentation contains cetain fowad-looking statements. These fowad-looking statements may be identified by wods such as believes,
Diabetes Care Beyond Meters and Strips
Diabetes Cae Beyond Metes and Stips R&D Day, May 2004 Staffan Ek Head of Diabetes Cae, Roche Diagnostics 1 Roche is well positioned in gowing maket segments Blood Glucose Monitoing maket size 7.3 bn CHF
Significant value in diagnostic information
U.S. Centalized Oveview Tom Adkins Vice Pesident Sales and Maketing Centalized, USA 1 Centalized Significant value in diagnostic infomation Diagnostic analysis of blood and othe body fluids pefomed in
Roche: Defining priorities for a high tech healthcare company
Roche: Defining priorities for a high tech healthcare company Erich Hunziker, Deputy Head of the Corporate Executive Committee and CFO January 2008 1 This presentation contains certain forward-looking
Welcome to Penzberg. One of Europe s largest biotech facilities
Welcome to Penzbeg One of Euope s lagest biotech facilities The Roche Goup s lagest biotech facility The Penzbeg site Pofile Role Diagnostics Phamaceuticals Futue Whee it all began The Penzbeg site in
Roche Diagnostics Positioned for growth
Roche Diagnostics Positioned fo gowth Heino von Pondzynski CEO Division Roche Diagnostics London, Septembe 9th, 2005 1 This pesentation contains cetain fowad-looking statements. These fowad-looking statements
Point of Care Testing market and Roche
US Point of Cae Oveview Rod Cotton Vice Pesident and Geneal Manage Point of Cae, USA 1 Point of Cae Testing maket and Roche Stategy and futue dives 2 Roche US Event Cotton, Point-of-Cae 1 Point-of-Cae
Controlling the Money Supply: Bond Purchases in the Open Market
Money Supply By the Bank of Canada and Inteest Rate Detemination Open Opeations and Monetay Tansmission Mechanism The Cental Bank conducts monetay policy Bank of Canada is Canada's cental bank supevises
Exam #1 Review Answers
xam #1 Review Answes 1. Given the following pobability distibution, calculate the expected etun, vaiance and standad deviation fo Secuity J. State Pob (R) 1 0.2 10% 2 0.6 15 3 0.2 20 xpected etun = 0.2*10%
Roche Interim results 2006. Roche Interim Results 2006 July 20, 2006 1
r Roche Interim results 2006 London, July 20, 2006 July 20, 2006 1 This presentation contains certain forward-looking statements. These forward-looking statements may be identified by words such as believes,
Converting knowledge Into Practice
Conveting knowledge Into Pactice Boke Nightmae srs Tend Ride By Vladimi Ribakov Ceato of Pips Caie 20 of June 2010 2 0 1 0 C o p y i g h t s V l a d i m i R i b a k o v 1 Disclaime and Risk Wanings Tading
Define What Type of Trader Are you?
Define What Type of Tade Ae you? Boke Nightmae srs Tend Ride By Vladimi Ribakov Ceato of Pips Caie 20 of June 2010 1 Disclaime and Risk Wanings Tading any financial maket involves isk. The content of this
Roche s RoACTEMRA improved rheumatoid arthritis signs and symptoms significantly more than adalimumab as single-agent therapy
Media Release Basel, 6 June 2012 Roche s RoACTEMRA improved rheumatoid arthritis signs and symptoms significantly more than adalimumab as single-agent therapy Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced
INITIAL MARGIN CALCULATION ON DERIVATIVE MARKETS OPTION VALUATION FORMULAS
INITIAL MARGIN CALCULATION ON DERIVATIVE MARKETS OPTION VALUATION FORMULAS Vesion:.0 Date: June 0 Disclaime This document is solely intended as infomation fo cleaing membes and othes who ae inteested in
Ignorance is not bliss when it comes to knowing credit score
NET GAIN Scoing points fo you financial futue AS SEEN IN USA TODAY SEPTEMBER 28, 2004 Ignoance is not bliss when it comes to knowing cedit scoe By Sanda Block USA TODAY Fom Alabama comes eassuing news
Trading Volume and Serial Correlation in Stock Returns in Pakistan. Abstract
Tading Volume and Seial Coelation in Stock Retuns in Pakistan Khalid Mustafa Assistant Pofesso Depatment of Economics, Univesity of Kaachi e-mail: [email protected] and Mohammed Nishat Pofesso and Chaiman,
9:6.4 Sample Questions/Requests for Managing Underwriter Candidates
9:6.4 INITIAL PUBLIC OFFERINGS 9:6.4 Sample Questions/Requests fo Managing Undewite Candidates Recent IPO Expeience Please povide a list of all completed o withdawn IPOs in which you fim has paticipated
An Introduction to Omega
An Intoduction to Omega Con Keating and William F. Shadwick These distibutions have the same mean and vaiance. Ae you indiffeent to thei isk-ewad chaacteistics? The Finance Development Cente 2002 1 Fom
Public Health and Transportation Coalition (PHiT) Vision, Mission, Goals, Objectives, and Work Plan August 2, 2012
Public Health and Tanspotation Coalition (PHiT) Vision, Mission, Goals, Objectives, and Wok Plan 2, 2012 Vision We envision Maine as a place whee people of all ages and abilities can move about in ways
IBM Research Smarter Transportation Analytics
IBM Reseach Smate Tanspotation Analytics Laua Wynte PhD, Senio Reseach Scientist, IBM Watson Reseach Cente [email protected] INSTRUMENTED We now have the ability to measue, sense and see the exact condition
Valuation of Floating Rate Bonds 1
Valuation of Floating Rate onds 1 Joge uz Lopez us 316: Deivative Secuities his note explains how to value plain vanilla floating ate bonds. he pupose of this note is to link the concepts that you leaned
Ilona V. Tregub, ScD., Professor
Investment Potfolio Fomation fo the Pension Fund of Russia Ilona V. egub, ScD., Pofesso Mathematical Modeling of Economic Pocesses Depatment he Financial Univesity unde the Govenment of the Russian Fedeation
Software Engineering and Development
I T H E A 67 Softwae Engineeing and Development SOFTWARE DEVELOPMENT PROCESS DYNAMICS MODELING AS STATE MACHINE Leonid Lyubchyk, Vasyl Soloshchuk Abstact: Softwae development pocess modeling is gaining
Chapter 3 Savings, Present Value and Ricardian Equivalence
Chapte 3 Savings, Pesent Value and Ricadian Equivalence Chapte Oveview In the pevious chapte we studied the decision of households to supply hous to the labo maket. This decision was a static decision,
STUDENT RESPONSE TO ANNUITY FORMULA DERIVATION
Page 1 STUDENT RESPONSE TO ANNUITY FORMULA DERIVATION C. Alan Blaylock, Hendeson State Univesity ABSTRACT This pape pesents an intuitive appoach to deiving annuity fomulas fo classoom use and attempts
FI3300 Corporate Finance
Leaning Objectives FI00 Copoate Finance Sping Semeste 2010 D. Isabel Tkatch Assistant Pofesso of Finance Calculate the PV and FV in multi-peiod multi-cf time-value-of-money poblems: Geneal case Pepetuity
Transmittal 47 Date: FEBRUARY 24, 2006
anual ystem Pub 100-03 edicae National oveage Deteminations Depatment of Health & Human evices (DHH) ente fo edicae & edicaid evices () Tansmittal 47 Date: EBUAY 24, 2006 hange equest 4257 UBJET: hanges
SNAPSHOT ASIA FIRST IN A SERIES OF REGIONAL SECTOR ANALYSES 2003 OCTOBER. Benchmarking FDI Competitiveness in Asia
FIRST IN A SERIES OF REGIONAL SECTOR ANALYSES 2003 OCTOBER Benchmaking FDI Competitiveness in Asia Copyight 2003 The Wold Bank Goup/MIGA 1818 H Steet, NW Washington, DC 20433 All ights eseved Manufactued
Smarter Transportation: The power of Big Data and Analytics
Smate Tanspotation: The powe of Big Data and Analytics Eic-Mak Huitema, Global Smate Tanspotation Leade IBM 1 Intelligent Tanspot Systems (ITS) fo the futue 2 BECAUSE WE WANT IT FOR THE FUTURE. How? The
Autoimmune Diseases More common than you think Randall Stevens, MD
Autoimmune Diseases More common than you think Randall Stevens, MD picture placeholder Autoimmune Diseases More than 60 different disorders Autoimmune disorders (AID) diseases caused by the immune system
Fixed Income Attribution: Introduction
18th & 19th Febuay 2015, Cental London Fixed Income Attibution: A compehensive undestanding of Fixed Income Attibution and the challenging data issues aound this topic Delegates attending this two-day
COMPLYING WITH THE DRUG-FREE SCHOOLS AND CAMPUSES REGULATIONS
Highe Education Cente fo Alcohol and Othe Dug Abuse and Violence Pevention Education Development Cente, Inc. 55 Chapel Steet Newton, MA 02458-1060 COMPLYING WITH THE DRUG-FREE SCHOOLS AND CAMPUSES REGULATIONS
883 Brochure A5 GENE ss vernis.indd 1-2
ess x a eu / u e a. p o.eu c e / :/ http EURAXESS Reseaches in Motion is the gateway to attactive eseach caees in Euope and to a pool of wold-class eseach talent. By suppoting the mobility of eseaches,
HEALTHCARE INTEGRATION BASED ON CLOUD COMPUTING
U.P.B. Sci. Bull., Seies C, Vol. 77, Iss. 2, 2015 ISSN 2286-3540 HEALTHCARE INTEGRATION BASED ON CLOUD COMPUTING Roxana MARCU 1, Dan POPESCU 2, Iulian DANILĂ 3 A high numbe of infomation systems ae available
The transport performance evaluation system building of logistics enterprises
Jounal of Industial Engineeing and Management JIEM, 213 6(4): 194-114 Online ISSN: 213-953 Pint ISSN: 213-8423 http://dx.doi.og/1.3926/jiem.784 The tanspot pefomance evaluation system building of logistics
Products of the Second Pillar Pension
Óbuda Univesity e-bulletin Vol. 4, No. 1, 2014 Poducts of the Second Pilla Pension Jana Špiková Depatent of Quantitative Methods and Infoation Systes, Faculty of Econoics, Matej Bel Univesity Tajovského
SUGGESTED SOLUTIONS. 21404 Strategic Financial Management. CA Professional (Strategic Level II) Examination June 2014
SUGGESTED SOLUTIONS 21404 Stategic Financial Management CA Pofessional (Stategic Level II) Examination June 2014 THE INSTITUTE OF CHARTERED ACCOUNTANTS OF SRI LANKA All Rights Reseved Answe No. 01 (a)
Roche Committed to innovation and profitable growth. Dr. Karl Mahler Head of Investor Relations. London, July 2011
Roche Committed to innovation and profitable growth Dr. Karl Mahler Head of Investor Relations London, July 2011 2 This presentation contains certain forward-looking statements. These forward-looking statements
Loyalty Rewards and Gift Card Programs: Basic Actuarial Estimation Techniques
Loyalty Rewads and Gift Cad Pogams: Basic Actuaial Estimation Techniques Tim A. Gault, ACAS, MAAA, Len Llaguno, FCAS, MAAA and Matin Ménad, FCAS, MAAA Abstact In this pape we establish an actuaial famewok
Personal Saving Rate (S Households /Y) SAVING AND INVESTMENT. Federal Surplus or Deficit (-) Total Private Saving Rate (S Private /Y) 12/18/2009
1 Pesonal Saving Rate (S Households /Y) 2 SAVING AND INVESTMENT 16.0 14.0 12.0 10.0 80 8.0 6.0 4.0 2.0 0.0-2.0-4.0 1959 1961 1967 1969 1975 1977 1983 1985 1991 1993 1999 2001 2007 2009 Pivate Saving Rate
A framework for the selection of enterprise resource planning (ERP) system based on fuzzy decision making methods
A famewok fo the selection of entepise esouce planning (ERP) system based on fuzzy decision making methods Omid Golshan Tafti M.s student in Industial Management, Univesity of Yazd [email protected]
An application of stochastic programming in solving capacity allocation and migration planning problem under uncertainty
An application of stochastic pogamming in solving capacity allocation and migation planning poblem unde uncetainty Yin-Yann Chen * and Hsiao-Yao Fan Depatment of Industial Management, National Fomosa Univesity,
Vector Calculus: Are you ready? Vectors in 2D and 3D Space: Review
Vecto Calculus: Ae you eady? Vectos in D and 3D Space: Review Pupose: Make cetain that you can define, and use in context, vecto tems, concepts and fomulas listed below: Section 7.-7. find the vecto defined
est using the formula I = Prt, where I is the interest earned, P is the principal, r is the interest rate, and t is the time in years.
9.2 Inteest Objectives 1. Undestand the simple inteest fomula. 2. Use the compound inteest fomula to find futue value. 3. Solve the compound inteest fomula fo diffeent unknowns, such as the pesent value,
Core therapeutic areas
Core therapeutic areas Platforms for growth Luke Miels, Executive Vice President, Global Portfolio & Product Strategy and Corporate Affairs Current business is led by core therapeutic areas Sales 9M 2014
Comparing Availability of Various Rack Power Redundancy Configurations
Compaing Availability of Vaious Rack Powe Redundancy Configuations White Pape 48 Revision by Victo Avela > Executive summay Tansfe switches and dual-path powe distibution to IT equipment ae used to enhance
NBER WORKING PAPER SERIES FISCAL ZONING AND SALES TAXES: DO HIGHER SALES TAXES LEAD TO MORE RETAILING AND LESS MANUFACTURING?
NBER WORKING PAPER SERIES FISCAL ZONING AND SALES TAXES: DO HIGHER SALES TAXES LEAD TO MORE RETAILING AND LESS MANUFACTURING? Daia Bunes David Neumak Michelle J. White Woking Pape 16932 http://www.nbe.og/papes/w16932
The impact of migration on the provision. of UK public services (SRG.10.039.4) Final Report. December 2011
The impact of migation on the povision of UK public sevices (SRG.10.039.4) Final Repot Decembe 2011 The obustness The obustness of the analysis of the is analysis the esponsibility is the esponsibility
Database Management Systems
Contents Database Management Systems (COP 5725) D. Makus Schneide Depatment of Compute & Infomation Science & Engineeing (CISE) Database Systems Reseach & Development Cente Couse Syllabus 1 Sping 2012
Chapter 11: Aggregate Demand II, Applying the IS-LM Model Th LM t
Equilibium in the - model The cuve epesents equilibium in the goods maket. Chapte :, Applying the - Model Th t C ( T) I( ) G The cuve epesents money maket equilibium. M L(, ) The intesection detemines
Faithful Comptroller s Handbook
Faithful Comptolle s Handbook Faithful Comptolle s Handbook Selection of Faithful Comptolle The Laws govening the Fouth Degee povide that the faithful comptolle be elected, along with the othe offices
David Loew, LCL MabThera
MabThera The star continues to rise David Loew, LCL MabThera MabThera the star continues to raise Group sales (CHF bn) 4,5 4,0 3,5 3,0 2,5 2,0 1,5 1,0 0,5 0,0 2001 2002 2003 2004 2005 Outstanding clinical
VISCOSITY OF BIO-DIESEL FUELS
VISCOSITY OF BIO-DIESEL FUELS One of the key assumptions fo ideal gases is that the motion of a given paticle is independent of any othe paticles in the system. With this assumption in place, one can use
An Epidemic Model of Mobile Phone Virus
An Epidemic Model of Mobile Phone Vius Hui Zheng, Dong Li, Zhuo Gao 3 Netwok Reseach Cente, Tsinghua Univesity, P. R. China [email protected] School of Compute Science and Technology, Huazhong Univesity
INTEGRATION AND COMPETITION IN THE EUROPEAN FINANCIAL MARKETS * Juan Fernández de Guevara, Joaquín Maudos and Francisco Pérez **
INTEGRATION AN COMPETITION IN THE EUROPEAN FINANCIA MARKETS * Juan Fenández de Guevaa, Joaquín Maudos and Fancisco Péez ** WP-EC 2003-12 Coesponding autho: Joaquín Maudos, Instituto Valenciano de Investigaciones
Comparing Availability of Various Rack Power Redundancy Configurations
Compaing Availability of Vaious Rack Powe Redundancy Configuations By Victo Avela White Pape #48 Executive Summay Tansfe switches and dual-path powe distibution to IT equipment ae used to enhance the availability
Roche A sustainable business model based on innovation and productivity gains
Roche A sustainable business model based on innovation and productivity gains William M. Burns, CEO Roche Pharmaceuticals Vontobel Summer Conference 2009, Interlaken 1 This presentation contains certain
Roche: Ensuring sustained success in a more challenging environment
Roche: Ensuring sustained success in a more challenging environment JP Morgan - January 2011 Dr. Erich Hunziker, Deputy Head of the Corporate Executive Committee and CFO This presentation contains certain
LATIN SQUARE DESIGN (LS) -With the Latin Square design you are able to control variation in two directions.
Facts about the LS Design LATIN SQUARE DESIGN (LS) -With the Latin Squae design you ae able to contol vaiation in two diections. -Teatments ae aanged in ows and columns -Each ow contains evey teatment.
Office Leasing Guide WHAT YOU NEED TO KNOW BEFORE YOU SIGN. Colliers International Office Leasing Guide P. 1
Office Leasing Guide WHAT YOU NEED TO KNOW BEFORE YOU SIGN Collies Intenational Office Leasing Guide P. 1 THE OFFICE LEASING GUIDE This step-by-step guide has been assembled to eflect Collies Intenational
Distributed Computing and Big Data: Hadoop and MapReduce
Distibuted Computing and Big Data: Hadoop and Map Bill Keenan, Diecto Tey Heinze, Achitect Thomson Reutes Reseach & Development Agenda R&D Oveview Hadoop and Map Oveview Use Case: Clusteing Legal Documents
How Much Should a Firm Borrow. Effect of tax shields. Capital Structure Theory. Capital Structure & Corporate Taxes
How Much Should a Fim Boow Chapte 19 Capital Stuctue & Copoate Taxes Financial Risk - Risk to shaeholdes esulting fom the use of debt. Financial Leveage - Incease in the vaiability of shaeholde etuns that
DOCTORATE DEGREE PROGRAMS
DOCTORATE DEGREE PROGRAMS Application Fo Admission 2015-2016 5700 College Road, Lisle, Illinois 60532 Enollment Cente Phone: (630) 829-6300 Outside Illinois: (888) 829-6363 FAX: (630) 829-6301 Email: [email protected]
Module Availability at Regent s School of Drama, Film and Media Autumn 2016 and Spring 2017 *subject to change*
Availability at Regent s School of Dama, Film and Media Autumn 2016 and Sping 2017 *subject to change* 1. Choose you modules caefully You must discuss the module options available with you academic adviso/
Media Release. Basel, 11 June 2009. RA patients with enhanced response identified
Media Release Basel, 11 June 2009 New data demonstrate the ability of MabThera to reduce the progression of joint damage when used as a first-line biologic treatment in rheumatoid arthritis RA patients
The Predictive Power of Dividend Yields for Stock Returns: Risk Pricing or Mispricing?
The Pedictive Powe of Dividend Yields fo Stock Retuns: Risk Picing o Mispicing? Glenn Boyle Depatment of Economics and Finance Univesity of Cantebuy Yanhui Li Depatment of Economics and Finance Univesity
GESTÃO FINANCEIRA II PROBLEM SET 1 - SOLUTIONS
GESTÃO FINANCEIRA II PROBLEM SET 1 - SOLUTIONS (FROM BERK AND DEMARZO S CORPORATE FINANCE ) LICENCIATURA UNDERGRADUATE COURSE 1 ST SEMESTER 2010-2011 Chapte 1 The Copoation 1-13. What is the diffeence
Forces & Magnetic Dipoles. r r τ = μ B r
Foces & Magnetic Dipoles x θ F θ F. = AI τ = U = Fist electic moto invented by Faaday, 1821 Wie with cuent flow (in cup of Hg) otates aound a a magnet Faaday s moto Wie with cuent otates aound a Pemanent
The LCOE is defined as the energy price ($ per unit of energy output) for which the Net Present Value of the investment is zero.
Poject Decision Metics: Levelized Cost of Enegy (LCOE) Let s etun to ou wind powe and natual gas powe plant example fom ealie in this lesson. Suppose that both powe plants wee selling electicity into the
Efficient Redundancy Techniques for Latency Reduction in Cloud Systems
Efficient Redundancy Techniques fo Latency Reduction in Cloud Systems 1 Gaui Joshi, Emina Soljanin, and Gegoy Wonell Abstact In cloud computing systems, assigning a task to multiple seves and waiting fo
Epdf Sulf petroleum, Eflecti and Eeflecti
ANALYSIS OF GLOBAL WARMING MITIGATION BY WHITE REFLECTING SURFACES Fedeico Rossi, Andea Nicolini Univesity of Peugia, CIRIAF Via G.Duanti 67 0615 Peugia, Italy T: +9-075-585846; F: +9-075-5848470; E: [email protected]
Data Center Demand Response: Avoiding the Coincident Peak via Workload Shifting and Local Generation
(213) 1 28 Data Cente Demand Response: Avoiding the Coincident Peak via Wokload Shifting and Local Geneation Zhenhua Liu 1, Adam Wieman 1, Yuan Chen 2, Benjamin Razon 1, Niangjun Chen 1 1 Califonia Institute
Welcome to the Cloud Stream. Sponsored by:
Welcome to the Cloud Steam Sponsoed by: Entepise Cloud (HEC) Hanessing the Powe of eal- Time Business with the Simplicity of the Cloud Ben Lingwood Diecto HEC GtM Entepise Cloud - Oveview Announced May
Common and Fundamental Factors in Stock Returns of Canadian Oil and Gas Companies
2004s-62 Common and Fundamental Factos in Stock Retuns of Canadian Oil and Gas Companies M. Matin Boye, idie Filion Séie Scientifique Scientific Seies Montéal écembe 2004 2004 M. Matin Boye, idie Filion.
Week 12 study results
Week 12 study results 15 April 2015 Copyright 2015 Galapagos NV Disclaimer This document may contain certain statements, including forward-looking statements, such as statements concerning the safety and
Continuous Compounding and Annualization
Continuous Compounding and Annualization Philip A. Viton Januay 11, 2006 Contents 1 Intoduction 1 2 Continuous Compounding 2 3 Pesent Value with Continuous Compounding 4 4 Annualization 5 5 A Special Poblem
cover comparison TUH it s my health fund! Your Queensland health fund Effective 2 April 2014
Effective 2 Apil 2014 You Queensland health fund cove compaison TUH it s my health fund! PLEASE CAREFULLY READ AND RETAIN THIS BROCHURE. PLEASE READ IN CONJUNCTION WITH THE Fine Points BROCHURE. waiting
Investment Horizons: Afghanistan
Benchmaking FDI Oppotunities Investment Hoizons: Afghanistan INVESTMENT HORIZONS: AFGHANISTAN 1 Copyight 2005 The Wold Bank Goup/MIGA 1818 H Steet, NW Washington, DC 20433 All ights eseved Manufactued
Left- and Right-Brain Preferences Profile
Left- and Right-Bain Pefeences Pofile God gave man a total bain, and He expects us to pesent both sides of ou bains back to Him so that He can use them unde the diection of His Holy Spiit as He so desies
Questions & Answers Chapter 10 Software Reliability Prediction, Allocation and Demonstration Testing
M13914 Questions & Answes Chapte 10 Softwae Reliability Pediction, Allocation and Demonstation Testing 1. Homewok: How to deive the fomula of failue ate estimate. λ = χ α,+ t When the failue times follow
How To Find The Optimal Stategy For Buying Life Insuance
Life Insuance Puchasing to Reach a Bequest Ehan Bayakta Depatment of Mathematics, Univesity of Michigan Ann Abo, Michigan, USA, 48109 S. David Pomislow Depatment of Mathematics, Yok Univesity Toonto, Ontaio,
Condom Social Marketing: Selected Case Studies
Condom Social Maketing: Selected Case Studies Joint United Nations Pogamme on HIV/AIDS UNICEF UNDP UNFPA UNDCP UNESCO WHO WORLD BANK Acknowledgements These case studies wee pepaed by Michael P. Fox, Consultant,
Firstmark Credit Union Commercial Loan Department
Fistmak Cedit Union Commecial Loan Depatment Thank you fo consideing Fistmak Cedit Union as a tusted souce to meet the needs of you business. Fistmak Cedit Union offes a wide aay of business loans and
Gauss Law. Physics 231 Lecture 2-1
Gauss Law Physics 31 Lectue -1 lectic Field Lines The numbe of field lines, also known as lines of foce, ae elated to stength of the electic field Moe appopiately it is the numbe of field lines cossing
Risk Sensitive Portfolio Management With Cox-Ingersoll-Ross Interest Rates: the HJB Equation
Risk Sensitive Potfolio Management With Cox-Ingesoll-Ross Inteest Rates: the HJB Equation Tomasz R. Bielecki Depatment of Mathematics, The Notheasten Illinois Univesity 55 Noth St. Louis Avenue, Chicago,
BEDFORDSHIRE AND LUTON JOINT PRESCRIBING COMMITTEE (JPC)
BEDFORDSHIRE AND LUTON JOINT PRESCRIBING COMMITTEE (JPC) September 2014 Review date: September 2017 Bulletin 203: Tocilizumab (subcutaneous) in combination with methotrexate or as monotherapy for the treatment