Vitamin A Palmitate Vitamin A Acetate

Transcription

1 Technical Information September 2007 Supersedes issue dated August 2006 Vitamin A Palmitate Vitamin A Acetate MEMC e-05/Page 1 of 6 = Registered trademark of BASF Aktiengesellschaft Active ingredient for the cosmetics industry.

2 MEMC e-05 September 2007 Page 2 of 6 Vitamin A Palmitate, Vitamin A Acetate Structural formula Product range Retinyl Palmitate 1.7 Mio IU/g Retinyl Palmitate 1.7 Mio IU/g stab. with Tocopherol Retinyl Palmitate 1.7 Mio IU/g stab. with BHT Retinyl Palmitate 1.0 Mio IU/g stab. with BHT Retinyl Palmitate 1.0 Mio IU/g stab with Tocopherol Retinyl Acetate 1.5 Mio IU/g stab. with BHT Retinyl Palmitate 1.0 Mio IU/g and Retinyl Acetate 1.5 Mio IU/g are diluted in Sunflower Seed Oil Synonyms Retinyl palmitate, all-trans-retinol palmitic acid ester Retinyl acetate, all-trans-retinol acetate INCI name Retinyl Palmitate 1.7 Mio IU/g: Retinyl Palmitate Retinyl Palmitate 1.0 Mio IU/g: Retinyl Palmitate (and) Helianthus Annuus (Sunflower) Seed Oil Retinyl Acetate 1.5 Mio IU/g: Retinyl Acetate (and) Helianthus Annuus (Sunflower) Seed Oil Molecular formula Retinyl Palmitate: C 36 H 60 O 2 Retinyl Acetate: C 22 H 32 O 2 Molar Mass Retinyl Palmitate g/mol Retinyl Acetate g/mol CAS-No (Retinyl Palmitate) (Retinyl Acetate) (Sunflower seed oil) PRD-No. Reninyl Palmitate 1.7 Mio Retinyl Palmitate 1.7 Mio stab. With Tocopherol Retinyl Palmitate 1.7 Mio stab. With BHT Retinyl Palmitate 1.0 Mio stab. With Tocoopherol Retinyl Palmitate 1.0 Mio stab. With BHT Retinyl Acetate 1.5 Mio stab. With BHT Description At room temperature, the product is a viscous, yellow oil that may contain some crystals. Mild odor. The assay of Vitamin A Palmitate 1.0 Mio IU/g and Vitamin A Acetate 1.5 Mio IU/g is adjusted by adding pharmaceutical-grade sunflower seed oil. Solubility Miscible with hydrocarbons, ethers, fats and oils. The solvent should contain no peroxides. Insoluble in water. It is necessary to use a solubilizer in aqueousalcoholic preparations.

3 MEMC e-05 September 2007 Page 3 of 6 Vitamin A Palmitate, Vitamin A Acetate Specification Monographs See separate document: Standard Specification (not for regulatory purposes) available via BASF s WorldAccount: (registered access). The product complies with the current Ph. Eur., USP and FCC monographs. Applications Vitamin A Esters are active ingredients for cosmetic skin-care products. They release Vitamin A on contact with enzymes in the skin. Vitamin A stimulates cell growth, increases enzyme activity and normalizes cell division. They are therefore able to counteract the skin-aging process and improve the appearance of UV-damaged skin. 1 International unit (IU) can be converted into weight with the following equations 1 IU = 0.3 µg Vitamin A alcohol (Retinol) µg Vitamin A Acetate 0.55 µg Vitamin A Palmitate Stability and storage Vitamin A Palmitate 1.7 Mio IU/G is available stabilized and unstabilized. All grades are available stabilized with approx. 10 mg of DL-alpha-Tocopherol per Mio IU or with approx. 10 mg of BHT per Mio IU. Vitamin A Esters are sensitive to air, light, moisture and heat. The product has a shelf life of 12 months if stored in the original sealed containers at max. 25 C, and 24 months at 5 C. Opened original containers should be flushed with an inert gas and used up quickly. Prior to use, the product must be heated to 40 C in the unopened container and homogenized. Occasionally difficult to dissolve crystals can be found in the product. In such cases placing the canister in a water bath at 60 C and letting it gently warm up, with homogenisation, will enable complete dissolution of the crystals. Typical formulations Antiaging cream No. 62/00035 % Ingredients Supplier INCI name A 2.00 Cremophor A 25 (1) Ceteareth Cremophor A 6 (1) Ceteareth-6, Stearyl Alcohol 5.00 Lanette O (27) Cetearyl Alcohol 5.00 Sunflower Seed Oil Sunflower (Helianthus Anuus) Seed Oil Luvitol EHO (1) Cetearyl Ethylhexanoate Paraffin Oil Mineral Oil B 0.05 Edeta BD (1) Disodium EDTA ,2-Propylene Glycol Care (1) Propylene Glycol 2.00 D-Panthenol 50 P (1) Panthenol, Propylene Glycol Preservative Water dem. Aqua C 0.50 Vitamin A Palmitate 1.7 Mio. I.E./g (1) Retinyl Palmitate 0.10 DL-alpha-Tocopherol (1) Tocopherol Perfume Production: Properties: Heat phases A and B separately to about 80 C. Stir phase B into phase A and homogenize. Cool to about 40 C, add phase C and homogenize again. Viscosity: 5000 mpa s Haake Viscotester VT-02 ph value: 7.0

4 MEMC e-05 September 2007 Page 4 of 6 Vitamin A Palmitate, Vitamin A Acetate Vitamin lotion No. 62/00042 % Ingredients Supplier INCI name A 6.00 Cremophor WO 7 (1) PEG-7 Hydrogenated Castor Oil 2.00 TeCero Wax 1030 K (73) Microcrystalline Wax 0.20 Bisabolol nat. (1) Bisabolol 1.00 Bees Wax 3044 PH (73) Bees Wax 0.50 Cetiol SB 45 (27) Butyrospermum Parkii (Shea Butter) 1.00 Jojoba Oil Jojoba (Buxus Chinensis) Oil 7.00 Luvitol EHO (1) Cetearyl Octanoate 7.00 Paraffin Oil Mineral Oil 0.10 Ascorbyl Palmitate Ascorbyl Palmitate B ,2-Propylene Glycol Care (1) Propylene Glycol 0.10 Edeta BD (1) Disodium EDTA Preservative 0.70 Magnesium Sulfate- 7-hydrate Water dem. Aqua (20) Magnesium Sulfate C 1.00 Vitamin E Acetate (1) Tocopheryl Acetate 0.50 DL-alpha-Tocopherol (1) Tocopherol 0.20 Vitamin A Palmitate 1.0 Mio. I.E./g 1.00 Vitamin F Glyceryl Ester Perfume (1) Retinyl Palmitate (58) Glyceryl Linoleate, Glyceryl Linolenate, Glyceryl Arachidonate D 2.50 Kollatherm (23) Soluble Collagen, Glycerol 1.00 Alpha-Elastin (23) Hydrolyzed Elastin Production: Properties: Heat phases A and B separately to about 85 C. Stir phase B into phase A and homogenize. Cool to about 40 C, add phases C and D and homogenize again. Viscosity: 6000 mpa s Haake Viscotester VT-02

5 MEMC e-05 September 2007 Page 5 of 6 Vitamin A Palmitate, Vitamin A Acetate Suppliers 1. BASF Aktiengesellschaft Ludwigshafen, Germany Tel.: (0621) 60-0 Fax: (0621) Merck KGaA Frankfurter Straße 250, Darmstadt, Germany Tel.: (06151) Fax: (06151) GFN Herstellung von Naturextrakten GmbH, Straßburg 16, D Wald-Michelbach, Germany Tel.: (06207) 7007 Fax: (06207) Cognis Deutschland GmbH - Care Chemicals Henkelstr Düsseldorf, Germany Tel.: (0211) Fax: (0211) Chemisches Laboratorium Dr. Kurt Richter GmbH (CLR) Bennigsenstraße 25, Berlin, Germany Tel.: 030/ Fax: 030/ Tromm GmbH, Wachs- und Ceresin-Fabriken Feuerstraße Köln (Weidenpesch) Tel Fax: Note While the descriptions, designs, data and information contained herein are presented in good faith and believed to be accurate, it is provided for your guidance only. Because many factors may affect processing or application/use, we recommend that you make tests to determine the suitability of a product for your particular purpose prior to use. NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, ARE MADE REGARDING PRODUCTS DESCRIBED OR DESIGNS, OR THAT DATA OR INFORMATION MAY BE USED WITHOUT INFRINGING THE INTELLECTUAL PROPERTY RIGHTS OF OTHERS. IN NO CASE SHALL THE DESCRIPTIONS, INFORMATION, DATA OR DESIGNS PROVIDED BE CONSIDERED A PART OF OUR TERMS AND CONDITIONS OF SALE. Further, you expressly understand and agree that the descriptions, design, data and information furnished by BASF hereunder are given gratis and BASF assumes no obligation or liability for the description, designs, data and information given or results obtained, all such being given and accepted at your risk. September 2006

6 MEMC e-05 September 2007 Page 6 of 6 Vitamin A Palmitate, Vitamin A Acetate BASF Corporation Fine Chemicals Division - Cosmetic Solutions Florham Park - USA, Region N.J.-