Mobile Stroke Treatment Units: A New Systems Concept
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1 Mobile Stroke Treatment Units: A New Systems Concept Peter A. Rasmussen, MD on behalf of the CV Center and CCT Director, Cerebrovascular Center Associate Professor Surgery (Neurosurgery) Medical Director of Distance Health
2 Disclosures last 12 months Consultant: Codman Neurovascular no compensation Financial Interest: Blockade Medical and Perflow Medical Scientific Advisory Boards Blockade Medical Medtronic Neurosurgery Stryker Neurovascular Perflow Medical Institutional/Group/Research and Educational Support: ev3/covidien Penumbra Medical Codman/J & J SNIS
3 There are 2 Effective Treatments for Acute Stroke
4 Time=Brain and the IV tpa Time Window Lancet 2010; 375: ; Lancet 2004; 363:
5 Patient Outcome vs. ΔTime (Onset to Treatment) Khatri, IMS3, ISC
6 Time is Brain! Neurons Lost Synapses Lost Accelerated Aging Per Stroke 1.2 billion 8.3 trillion 36 yrs Per Hour 120 million 830 billion 3.6 yrs Per Minute 1.9 million 14 billion 3.1 weeks Per Second 32, million 8.7 hrs (Total number of neurons in the average human brain is 130 billion) Stroke 2006;37:
7 Door to physician 10 minutes Door to neurologist 15 minutes Door to CT 25 minutes Door to read CT 45 minutes Door to needle 60 minutes TIME GOALS Stroke 2013;44; SIMPOSIO FLENI 2003
8
9 Stroke (Cerebrovascular Disease) Impact and Overview Devastating Problem Yearly Discharge Volume Adult Prevalence Yearly Mortality Stroke Mortality Rank 5 Yr Projected IP Growth Cuyahoga County 5, % rd 3% CC Slow to Improve 2013 Data A B C D E F G H I IVtPA delivery rate 17% 10% 11% 4% 7% 6% 18% 10% 0% Door to Drug in 60 min
10 Global IVtPA Underuse Modeling indicates that 23% can be achieved with prealert, 4.5hrs, > 80 yrs UK, 24% achieved in Sweden Monks et al. Stroke 2012; Bergland,Stroke 2012 Improved DTN crucial; Foranow Stroke Meratoja, Neurology 2012 Estimated 4.5% to 5.2% USA (Boehringer Ingelheim; Adeoye Stroke 2011; Foranow Stroke 2011) Huge Variation in Europe Finland 16% (Meratoja 2012), Germany 11.7% (Minnerup Stroke 2011), Sweden 6.6% (Eriksson Stroke 2010), UK 5.8%, France 3%, Italy 1.2% (T Fischer Pers com 2013 Boehringer Ingelheim) Much lower rates in developing world <1%
11 Recognize Maximum Benefit to Patient is Earlier Treatment We cannot expect the patient s disease biology to match our systems. Because the time window to treatment with stroke for most is so short, we must match our stroke care system to the biology. Michael Hill, MD 12
12 Stroke Treatment Decisions Hinge on the CT Scan BP control IV tpa (clot buster) Transport to Primary Stroke Center BP control Warfarin reversal Mannitol Anti-epiletic medications Transport to Comprehensive Stroke Center
13 Berlin University of Saarland First in the World
14 Randomized, single center Week on, week off Primary endpoint alarm to therapy decision Secondary alarm to end of CT, alarm to lab analysis, # pts IV tpa, 7 day neurological outcome (NIHSS) 17
15 Week on, week off randomization Compared STEMO deployment vs.stemo weeks vs. control weeks tpa utilization improved to 33% (vs. 21% in control weeks)
16 Realization that CCF needed to make a systems change US facing a health care crisis Costs too high Access too low Need to constantly innovate our care delivery model Need to decrease costs Most cost of stroke patient is after acute hospitalization Need to reduce these costs Best way to reduce rehabilitation/disability costs is to reduce deficit Need to increase tpa delivery and access to endovascular therapy Need to bring highest possible level of care directly to the patient as soon as possible 20
17 Mobile Stroke Treatment Unit: Diagnosis and Emergency Care Don t wait for the patient to go to ER Bring the CT and stroke expertise to the patient Initiate treatment at the scene Dramatically cut time-to-treatment decisions Triage patient to appropriate stroke resource 23
18
19 Portable CT technology CereTom (Neurologica, Danvers, MA) 8 slice CT CTA/CTP capable Able to scan head Used for a number of years in our NICU Reasonable quality
20 Telemedicine Inter-rater reliability reasonable to in person assessment Berlin kappa 0.69 Houston with mock patient absolute agreement Reliable Broadband has been limiting step world-wide Berlin: only 18/30 technically successful connections Verizon 4GLTE Priority secure network Same as police, fire, EMS
21 Operations Stroke patient calls 911 activates Emergency Medical System Municipal ambulance dispatched simultaneously with MSTU (8a-8p) Local ambulance arrives first usual assessment, IV, O 2, draws blood samples MSTU arrives mutual care/hand off of care CT head performed -> transmitted for neuroradiologist and neurologist review Point of Care Testing for CBC, INR, creatinine, glucose Telestroke System -> vascular neurologist virtually with the patient and team, Initiate IV tpa or other care as appropriate Triage to appropriate hospital (level of care) in stroke system
22 MSTU Triage Guideline YES YES YES YES YES YES NO
23 Treatment Paradigm of the Future? 43 y.o. with prior history of drug abuse, CHF Was with girlfriend who left briefly, came back 10 minutes later to find him with left hemiplegia Called 911 EMS and MSTU dispatched MSTU arrived 40 minutes post symptom onset
24 MSTU Telemedicine Vascular neurologist virtual evaluation - patient with dense left sided weakness and altered LOC, difficulty speaking NIHSS 20
25 Non contrast CT
26 Treatment Initiated IV tpa initiated at 11 minutes after patient on board MSTU! Transferred to Cleveland Clinic Main Campus for endovascular treatment of elvo (due to high NIHSS, hyperdense MCA sign)
27 Initial runs right M1 MCA occlusion
28
29 One pass with aspiration cath M1 recanalized, M3 thrombus (angular branch remaining)
30 Patient Course Improved next day with near resolution, only facial droop remained (NIHSS 1) Stroke due to underlying CHF (EF 10%) Discharged home on hospital day 4
31 Mobile Stroke Program at a Glance Days in service to date: 345 Total dispatches: 1143 Total transports: 291 Cleveland Clinic: 128 Metro Hospital: 57 University Hospital: 37 Lakewood Hospital: 14 Euclid Hospital: 13 Fairview Hospital: 13 Marymount Hospital: 8 St. Vincent Charity: 7 South Pointe Hospital: 5 Parma Hospital: 4 Southwest General Hospital: 3 Lutheran Hospital: 1 Hillcrest Hospital: 1 July 18 th, 2014 June 30 th, 2015 * Not all transports were determined to be stroke on MSTU physician assessment Data as of 6/30/2015
32 Pre-hospital Treatments IV TPA administered in the field Average Door to Drug Time Endovascular Therapy 6 3 Hemorrhagic Strokes Transported 7 10 Data as of 5/31/2015
33 Data Metrics Dispatch to Scene Arrival January 2015 February 2015 March 2015 April 2015 May MSTU Door to Doctor MSTU Door to CT complete MSTU Door to CT Read MSTU Door to Lab Results MSTU Door to Drug Total Time on Scene Dispatch to Hospital Arrival Transport time (Scene to Hosp)
34 Primary Stroke Metrics
35 911 Alarm to..
36 MSTU Thrombolysis Rate Thrombolysis Rate: Based on MSTU encounter Dx (n=100 patients) IV tpa given for 100 MSTU runs: 16% Rate in probable stroke = 16/33 = 48.4% Based on Final Dx (known for 87 pts) Rate in AIS: 9/29 = 31.0% Rate in AIS + clinical TIA = 11/41 = 26.8%
37 MSTU comparison to CCHS EDs MSTU HC MC Fairview Medina MYMT ACMC LKWD SP # IV tpa Administration in ED Door to Drug (Target <60 min) month data 12 hrs/day operation 12 month data
38
39 Number of Patients Who Benefit and Are Harmed per 100 Patients tpa Treated in Each Time Window Lansberg et al, Stroke Minutes Benefit Harm
40 Right Patient, Right Place, the First Time Thus far, no patients have required a second transfer
41 Summary and Next Steps We have achieved goals of the program Community acceptance and satisfaction Decreased time to drug (treatment) Increased access to best in class treatment Near perfect triage of patients to appropriate resource in community Successful collaboration with Cleveland hospital systems Expand access of this program to Cleveland Metro Area
42 Acknowledgements Cerebrovascular Center and Critical Care Transport Programs Matt Stanton/Brian Perse (CV Center Administrators) Stacey Winners (MSTU Program Manager) Cleveland Pre-Hospital Acute Stroke Treatment (PHAST) Study Group Drs. Mike Modic and Robert Wyllie Executive Sponsors
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44 Title of Presentation Arial Regular 22pt Single line spacing Up to 3 lines long Date 20pts Author Name 20pts Author Title 20pts
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