Updating the 2008 WHO Classification of Small B cell lymphomas Elias Campo
|
|
- August Bates
- 8 years ago
- Views:
Transcription
1 Updating the 2008 WHO Classification of Small B cell lymphomas Elias Campo Hospital Clinic, University of Barcelona Barcelona, Spain
2 Disclosure of Relevant Financial Relationships Dr. ELIAS CAMPO declares he has no conflict(s) of interest to disclose.
3 Chronic Lymphocytic Leukemia/ Small Lymphocytic Lymphoma Maintain current definitions (> 5 x10 9 /L monoclonal lymphocytes with the CLL phenotype) Extramedullary tissue involvement and cytopenias allow for lower number of atypical lymphocytes SLL is the same disease but restricted to tissues of non-leukemic (< 5 x10 9 /L) patients without cytopenias B clonal (x10 9 /L) Lymphocytes (x10 9 /L) WHO 2008
4 Monoclonal B-cell Lymphocytosis Definitions and Subtypes Monoclonal B-cells 5000 x 10 9 /L Absence of other lymphoproliferative disorders or autoimmune disease CLL-like (70%) Atypical CLL* (15%) Non-CLL* (15%) * Cytogenetic studies are recommended Low-count MBL Low lymphocyte and B cell counts (usually <50/μl) Different IGHV/No stereotyped BCR Very low risk of progression (if any) No indication to monitor even if detected incidentally Clinical MBL High lymphocyte and B cell counts ( /μl) Lymphocytosis High risk cytogenetic alterations (5-9%) Annual progression requiring treatment 1-2% Clinical monitoring Dagklis et al Blood 2009 Karube et al Sem Cancer Biol 2014
5 Non-CLL MBL (CD5- MBL / Clonal B-cell lymphocytosis) Bone marrow involvement (sinusoidal) / 80% lymphocytosis > 4 x 10 9 /L Phenotype/Genotype suggestive of splenic lymphoma CD49d+/CD38-, CD10-; 20% CD5+ weak 72% aberrant karyotypes, del(7q) 15%, transloc 7q 13%, i(17q) 17% V4-34 (23%) V1-2 (6%) (More similar to SDRP than SMZL) 17% Progression (most) with splenomegaly and other lymphomas (MZL) Xochelli A et al Blood 2014 MBL nodal counterpart Atypical cells with CLL phenotype in otherwise reactive LN Absence of proliferation centers; < 1.5 cm nodes Gibson SE et al Haematologica 2011
6 Histological Progression in CLL Clinical significance of proliferation centers Heterogeneous terminology: Accelerated CLL Proliferation center-rich-cll Histologically Aggressive CLL CLL with expanded proliferation centers Expanded / confluent proliferation centers - High proliferation (Ki67 >30%) - Del(11q) 25%, del(17p) 16%, t(14q) 31% Histological criteria not standardized Survival intermediate between CLL and Richter transformation P < 0.01 Ki67 Standard CLL Gine E et al Haematologica 2010; 95: Ciccone M et al Leukemia : Falchi L et al Blood 2014; 123; RS Expanded PC
7 New Markers in CLL LEF1 1 Transcitpion factor, wnt pathway Useful in the diagnosis of CLL in tissues: 100% expression in CLL but not in other small B-cell lymphomas Caveat: Expression in 40% DLBCL LEF1 CD Immunoglobulin superfamily - Expressed in CLL, HCL, and FL - Negative in MCL but positive in 24% indolent SOX11-negative MCL 3 CD49d 4 Integrin family Prognostic value independent of CD38/ ZAP70 Predictive value for BCR-targeted therapies? 1 Tandomn B et al Mod Pathol. 2011, 24: Challangundla L et al Am J Clin Pathol 2014; Espinet B et al Clin Cancer Res 2013; 20: Bullan P et al J Clin Oncol 2014; 32:
8 Lymphomas with plasmacytic differentiation Role of MYD88 mutation >90% Waldenström macrogl/lpl >50% IgM MGUS TLR MYD88 IRAKs NF-kB pathway MAPK pathways Inflammatory cytokines and chemokines 70% LBCL CNS & Testis 29% DLBCL-ABC 7-9% MALT 0-10% SMZL* 0-24% nmzl* 3% CLL L265P, most common mutation, detectable in FFPE tissues Useful information in the differential diagnosis * Interpret with caution results in the literature Ngo VN et al Nature 2011; 470:115 9; Treon SP et al N Engl J Med 2012; 367:826 33; Landgren O et al Leukemia 2014; 28: ; Hamadeh F et al Modern Pathol 2014 e pub
9 Lymphoplasmacytic Lymphoma MYD88 and CXCR4 Somatic mutations MYD % WM/LPL CXCR4 25% WM; Resistance to Ibrutinib Broader spectrum of cytological and architectural patterns 1 Diffuse architecture Follicular colonization Monotonous lymphoid population, minor plasmacytic morphology Polymorphic composition most probably other entities 1 Recognition of anomalous phenotypes 2,3 CD10 + (3-16%), CD5+ (17% ) IgD+, CD21 IgM MGUS carries MYD88 mutations in 47-87% 4 Precursor of LPL/WM. Gamma heavy chain disease lacks MYD88 L265P and is not considered LPL 5 CD10 IgD 1 Hamadeh F et al Modern Pathol 2014 e pub; 2 Konoplev et al Am J Clin Pathol 2005; 124: ; 3 Lin P et al Am J Clin Pathol 2011; 136: ; 4 Landgren O et al Leukemia 2014; 28: ; 5 Haematologica 2014;99(9):e154 5
10 Early steps in Follicular Lymphoma In Situ and early involvement lesions t(14;18) in peripheral blood Detection require sensitive methods Most do not progress but some evidences of FL precursor in situ follicular neoplasia Incidental finding Low incidence of progression (<5%) Need to exclude systemic lymphoma Jegalian AG et al Blood 2011 Partial involvement by FL 50% progress to overt FL Adam P et al AJSP 2005 Mamessier E et al Haematologica 2014; 99:
11 Follicular lymphoma grading Maintain current grading system 1 2, 3a and 3b Some cases do not fit well in classical definitions Low morphological grade with high proliferation 1 FL «pediatric type» 2 FL with blastoid morphology 3 FL grade 3B Relation to GC type DLBCL Low frequency of t(14;18) High IRF4 expression in some cases (3A/B, elderly, nodal, CD10 negative, high Ki67) 4 IRF4 1 Wang SA et al Am J Surg Pathol. 2005;29:1490 6; 2 LiuQ et al Am J Surg Pathol. 2013;37:333 43; 3 Natkunam Y et al Am J Surg Pathol. 2000;24:525 34; 4 Karube K et al Blood. 2007;109:3076 9
12 Different subtypes of t(14;18) negative FL FL with conventional morphology 1 30% BCL2 protein positive Lower GC expression signature (CD10 negative) Higher proliferation No clinical impact Diffuse variant of FL 2 Large nodal tumors in inguinal region Localized disease CD10, BCL2, BCL6, CD23 positive Del 1p36 Primary extranodal FL (e.g. cutaneous) 1 Leich et al. Blood 2009;114: Katzeberger T et al Blood 2009;113:
13 Pediatric lymphomas (come of age) Follicular Lymphoma Pediatric Type Children and young adults Striking male predominance Nodal presentation, head and neck Expansile GC with grade 3, blastic No diffuse areas High proliferation rate CD21 Lack of t(14;18) Excellent prognosis Watch & wait therapy recommended BCL2 Liu Q et al Am J Surg Pathol. 2013;37: Louissaint A Jr et al Blood. 2012, 120:
14 Large B-cell lymphoma with IRF4 rearrangement New provisional entity segregated from other pediatric FL Waldeyer s ring, head and neck nodal, bowel presentation Most commonly in children/young adults Follicular and diffuse areas with grade 3 Germinal center phenotype (CD10/BCL6) BCL2 expression but no t(14;18) IRF4 Strong IRF4 expression and IRF4 translocation Cases without the genetic alteration may not be detected Treatment is often required IRF4 BAP Caution: name subject to change, precise criteria yet to be determined since IRF4 + not specific Salaverria I et al Blood 2011;118:139 47; Liu Q et al Am J Surg Pathol. 2013;37:333 43
15 Mantle cell lymphoma CCND1-negative variant CCND2 trans 55% Classic MCL Cyclin D1 CCND1 neg MCL Cyclin D1 Sox11 Mozos et al Haematologica 2009 Salaverria et al Blood 2013
16 Mantle cell lymphoma Indolent Variants Clinical concept with different pathological conditions In situ MC neoplasia, Mantle zone pattern, low proliferation index (SOX11+ or SO11-) In situ MC neoplasia Mantle Zone MCL Low proliferation Non-nodal leukemic subtype of MCL Non nodal leukemic (splenomegaly) disease SOX11 negative Hypermutated IGHV Simple karyotypes May transform into blastoid MCL (TP53 mut) Richard et al J Clin Pathol 2006; Jares P et al J Clin Invest 2013
17 NGS in small B cell lymphomas Complex landscape of somatic mutations in different tumors with two major patterns One mutated gene in most cases of the disease Great heterogeneity with few frequently mutated genes and higher number of genes with low recurrence rate Mutated genes cluster in functional pathways Common mutated genes and pathways across entities
18 Diagnostic value of somatic mutations in mature samll B-cell lymphoid neoplasms 90% WM Waldenstrom M MYD88 L265P 29% DLBCL-ABC 6% MZL 3% CLL Hairy Cell Leukemia BRAF V600E % HCL 4% Plasma cell myeloma 3% NHL (Other BRAF mut) HCL-v HCLc IGHV4-34 MAP2K1 50% HCLv 50% HCLc IGHV4-34 0% HCL BRAFmut Tiacci et al NEJM 2011 Ngo Nature 2011; Puente Nature 2011; Xi L et al Blood 2012; Xu et al ASH 2011; Hunter Z et al ASH 2011;Waterfall Nat Genet 2014
19 Recurrently mutated pathways in small B-cell lymphoid neoplasms Pathway U-CLL M-CLL MCL FL GCB NFkB + +/- Chromatin Remodeling + + TLR/MYD88 +/- DNA-damage + + NOTCH1/2 + +/- + + SF3B1 (RNA metabolism) + +/- SMZL HCL BRAF +
20 Clinical Relevance of Mutational Profiles in Lymphoid Neoplasms Diagnostic criteria to refine entities Identification of subsets of patients Prognostic and predictive significance Monitoring disease evolution: Dynamic evolution of mutational landscape Targets for therapy: Actionable mutations
21 Updating WHO classification What s new in small B-cell lymphomas? Refinement of definitions, diagnostic criteria and terminology MBL variants, LPL, in situ Follicular and Mantle cell neoplasias Inclusion of new defined entities and variants FL t(14;18) negative, MCL variants Provisional entities: Updates and open questions FL Pediatric type, IRF4 + LBCL, Relevance and clinical impact of NGS
B-cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
2008 WHO Classification of Lymphoid Neoplasms: Small B-Cell Neoplasms Chronic lymphocytic leukemia/small lymphocytic lymphoma B-cell prolymphocytic leukemia Splenic marginal zone B-cell lymphoma Hairy
More informationLymphoplasmacytic Lymphoma. Hematology fellows conference 4/12/2013 Christina Fitzmaurice, MD, MPH
Lymphoplasmacytic Lymphoma versus IGM Multiple Myeloma Hematology fellows conference 4/12/2013 Christina Fitzmaurice, MD, MPH Hematology consult patient 48 yo woman presents to ER with nonspecific complaints:
More informationInteresting Case Review. Renuka Agrawal, MD Dept. of Pathology City of Hope National Medical Center Duarte, CA
Interesting Case Review Renuka Agrawal, MD Dept. of Pathology City of Hope National Medical Center Duarte, CA History 63 y/o male with h/o CLL for 10 years Presents with worsening renal function and hypercalcemia
More informationMature Lymphoproliferative disorders (2): Mature B-cell Neoplasms. Dr. Douaa Mohammed Sayed
Mature Lymphoproliferative disorders (2): Mature B-cell Neoplasms Dr. Douaa Mohammed Sayed Small lymphocytic lymphoma/b-cell chronic lymphocytic leukemia BMB: nodular, interstitial, diffuse or a combination
More informationGenomic Analysis of Mature B-cell Malignancies
Genomic Analysis of Mature B-cell Malignancies Update and Lessons Learned Omar Abdel-Wahab, MD Memorial Sloan Kettering Cancer Center Human Oncology and Pathogenesis Program and Leukemia Service Disclaimer:
More informationLYMPHOMA. BACHIR ALOBEID, M.D. HEMATOPATHOLOGY DIVISION PATHOLOGY DEPARTMENT Columbia University/ College of Physicians & Surgeons
LYMPHOMA BACHIR ALOBEID, M.D. HEMATOPATHOLOGY DIVISION PATHOLOGY DEPARTMENT Columbia University/ College of Physicians & Surgeons Normal development of lymphocytes Lymphocyte proliferation and differentiation:
More informationMalignant Lymphomas and Plasma Cell Myeloma
Malignant Lymphomas and Plasma Cell Myeloma Dr. Bruce F. Burns Dept. of Pathology and Lab Medicine Overview definitions - lymphoma lymphoproliferative disorder plasma cell myeloma pathogenesis - translocations
More informationFlow Cytometric Evaluation of B-cell Lymphoid Neoplasms
Clin Lab Med 27 (2007) 487 512 Flow Cytometric Evaluation of B-cell Lymphoid Neoplasms Fiona E. Craig, MD Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine,
More informationMantle Cell Lymphoma. Elías Campo
Mantle Cell Lymphoma Elías Campo Hematopathology Section, Department of Anatomic Pathology, Hospital Clínic, Institut d Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona,
More informationDiffuse Large B-cell Lymphoma, Burkitt Lymphoma and the Gray Zone. Relative Frequency of B-cell NHL. Diffuse Large B-cell Lymphoma Definition
Diffuse Large B-cell Lymphoma, Burkitt Lymphoma and the Gray Zone L. Jeffrey Medeiros, M.D. M.D. Anderson Cancer Center Relative Frequency of B-cell NHL Diffuse large B-cell lymphoma 37 % Follicular lymphoma
More informationNon-Hodgkin s Lymphoma
Non-Hodgkin s Lymphoma Luis Fayad, MD Assistant Professor Clinical Medical Director Lymphoma/Myeloma Department Non-Hodgkin s Lymphoma Non-Hodgkin s lymphomas (NHL) are a heterogeneous group of malignant
More informationAbout B Cell Lymphomas Groupmeeting Klipp/Spang, December 09 2002 Dennis Kostka Max-Planck-Institute for Molecular Genetics Computational Molecular Biology Berlin 1 Overview Short History of Lymphoma Classification
More informationBone Marrow Evaluation for Lymphoma. Faizi Ali, MD Hematopathology Fellow William Beaumont Hospital
Bone Marrow Evaluation for Lymphoma Faizi Ali, MD Hematopathology Fellow William Beaumont Hospital Indications One of the most common indications for a bone marrow biopsy is to evaluate for malignant lymphoma.
More informationOutline of lecture. Disclosures. Current Issues in Practical Hematopathology: Diagnosis of Bone Marrow Lymphomas
Current Issues in Practical Hematopathology: Diagnosis of Bone Marrow Lymphomas Disclosures I have no disclosures relevant to the content of this lecture Robert P Hasserjian, MD Associate Professor Massachusetts
More informationWaldenström Macroglobulinemia: The Burning Questions. IWMF Ed Forum May 18 2014 Morie Gertz MD, MACP
Waldenström Macroglobulinemia: The Burning Questions IWMF Ed Forum May 18 2014 Morie Gertz MD, MACP Are my kids going to get this? Familial seen in approximately 5 10% of all CLL patients and can be associated
More informationPulling the Plug on Cancer Cell Communication. Stephen M. Ansell, MD, PhD Mayo Clinic
Pulling the Plug on Cancer Cell Communication Stephen M. Ansell, MD, PhD Mayo Clinic Why do Waldenstrom s cells need to communicate? Waldenstrom s cells need activating signals to stay alive. WM cells
More informationMonoclonal B-Cell Lymphocytosis
Monoclonal B-Cell Lymphocytosis Identification of parameters involved in the pathogenesis and in a higher risk of malignant transformation Belen Espinosa Degree project in biology, Master of science (2
More informationLymphoma Diagnosis and Classification
Lymphoma Diagnosis and Classification By Atef Shrit, MD, Pathology B- and T/NK-cell lymphomas are clonal neoplasms of immature and mature B-lymphocytes, T-lymphocytes or natural killer cells at various
More informationWhat to know about the B-cell neoplasms Steven H. Swerdlow, M.D.
What to know about the B-cell neoplasms Steven H. Swerdlow, M.D. Bullet points and key words The 2008 Revised WHO monograph on Tumours of the haematopoietic and lymphoid tissues includes many changes among
More informationFlow Cytometric Diagnosis of Low Grade B-cell Leukemia/Lymphoma
Flow Cytometric Diagnosis of Low Grade B-cell Leukemia/Lymphoma Maryalice Stetler-Stevenson, M.D., Ph.D. Flow Cytometry Unit, Laboratory of Pathology, DCS, NCI,NIH DEPARTMENT OF HEALTH & HUMAN SERVICES
More informationchronic leukemia lymphoma myeloma differentiated 14 September 1999 Pre- Transformed Ig Surface Surface Secreted Myeloma Major malignant counterpart
Disease Usual phenotype acute leukemia precursor chronic leukemia lymphoma myeloma differentiated Pre- B-cell B-cell Transformed B-cell Plasma cell Ig Surface Surface Secreted Major malignant counterpart
More informationWhy discuss CLL? Common: 40% of US leukaemia. approx 100 pa in SJH / MWHB 3 inpatients in SJH at any time
Why discuss CLL? Common: 40% of US leukaemia approx 100 pa in SJH / MWHB 3 inpatients in SJH at any time Median age of dx is 65 (30s. Incurable, survival 2-202 20 years Require ongoing supportive care
More informationCollaboration to collect Autologous transplant outcomes in Lymphoma and Myeloma (CALM) Additional Questionnaire (MED C) INCLUSION CRITERIA CALM STUDY
Additional Questionnaire (MED C) CALM study Inclusion period: 01/01/2008 to 31/12/2011 PATIENT REGISTRATION FORM Disease Diagnosis Lymphoma S Non Hodgkin Lymphoma (NHL) Mature B-cell neoplasm Follicular
More informationCancer. 9p21.3 deletion. t(12;21) t(15;17)
CANCER FISH PROBES INDIVIDUAL AND PANEL S Acute Lymphoblastic Leukemia (ALL) ALL FISH Panel (includes all probes below) 8010 LSI MYB/CEP6 LSI p16 (CDKN2A) LSI BCR/ABL with ASS LSI ETV6 (TEL)/AML1 (RUNX1)
More informationCLL: Disease Course, Treatment, Diagnosis, and Biomarkers
CLL: Disease Course, Treatment, Diagnosis, and Biomarkers Amy E. Hanlon Newell, Ph.D. Manager, Scientific Affairs Abbott Molecular Overview: Today s Take-away Understanding of: Cell phenotype and clinical
More informationMALIGNANT LYMPHOMAS. Dr. Olga Vujovic (Updated August 2010)
MALIGNANT LYMPHOMAS Dr. Olga Vujovic (Updated August 2010) Malignant lymphomas consist of Hodgkin and non-hodgkin lymphomas. The current management of these diseases involves a multi-disciplinary approach.
More informationAn overview of CLL care and treatment. Dr Dean Smith Haematology Consultant City Hospital Nottingham
An overview of CLL care and treatment Dr Dean Smith Haematology Consultant City Hospital Nottingham What is CLL? CLL (Chronic Lymphocytic Leukaemia) is a type of cancer in which the bone marrow makes too
More informationOncology Best Practice Documentation
Oncology Best Practice Documentation Click on the desired Diagnoses link or press Enter to view all information. Diagnoses: Solid Tumors Lymphomas Leukemias Myelodysplastic Syndrome Pathology Findings
More informationMantle Cell Lymphoma Understanding Your Treatment Options
New Developments in Mantle Cell Lymphoma John P. Leonard, M.D. Richard T. Silver Distinguished Professor of Hematology and Medical Oncology Associate Dean for Clinical Research Vice Chairman, Department
More informationLeukemias and Lymphomas: A primer
Leukemias and Lymphomas: A primer Normal blood contains circulating white blood cells, red blood cells and platelets 700 red cells (oxygen) 1 white cell Neutrophils (60%) bacterial infection Lymphocytes
More information亞 東 紀 念 醫 院 Follicular Lymphoma 臨 床 指 引
前 言 : 惡 性 淋 巴 瘤 ( 或 簡 稱 淋 巴 癌 ) 乃 由 體 內 淋 巴 系 統 包 括 淋 巴 細 胞 淋 巴 管 淋 巴 腺 及 一 些 淋 巴 器 官 或 組 織 如 脾 臟 胸 腺 及 扁 桃 腺 等 所 長 出 的 惡 性 腫 瘤 依 腫 瘤 病 理 組 織 型 態 的 不 同 可 分 為 何 杰 金 氏 淋 巴 瘤 (Hodgkin s disease) 與 非 何 杰 金
More informationMULTIPLE MYELOMA. Dr Malkit S Riyat. MBChB, FRCPath(UK) Consultant Haematologist
MULTIPLE MYELOMA Dr Malkit S Riyat MBChB, FRCPath(UK) Consultant Haematologist Multiple myeloma is an incurable malignancy that arises from postgerminal centre, somatically hypermutated B cells.
More informationAnti-HCV therapy in HCV-related NHL
Gabriele Pozzato M.D. University of Trieste Anti-HCV therapy in HCV-related NHL Questions about HCV+ in NHL Is the NHL related with HCV infection? Which is the best therapeutic strategy? Is the antiviral
More informationChronic Lymphocytic Leukemia. Case Study. AAIM Triennial October 2012 Susan Sokoloski, M.D.
Chronic Lymphocytic Leukemia AAIM Triennial October 2012 Susan Sokoloski, M.D. Case Study 57 year old male, trial application for $1,000,000 Universal Life coverage Cover letter from sales agent indicates
More informationAggressive lymphomas. Michael Crump Princess Margaret Hospital
Aggressive lymphomas Michael Crump Princess Margaret Hospital What are the aggressive lymphomas? Diffuse large B cell Mediastinal large B cell Anaplastic large cell Burkitt lymphoma (transformed lymphoma:
More informationFrequency of NHL Subtypes in Adults
Chemotherapy Options Stephanie A. Gregory, M.D. The Elodia Kehm Professor of Medicine Director, Section of Hematology Rush University Medical Center Chicago, Illinois Frequency of NHL Subtypes in Adults
More informationMolecular Diagnostics in Thyroid Cancer
Disclosure Nothing to disclose Jonathan George, MD, MPH Assistant Professor Head and Neck Oncologic & Endocrine Surgery Molecular Diagnostics in Thyroid Cancer Current Practices & Future Trends UCSF Medical
More informationMultiple Myeloma and Colorectal Cancer
Multiple Myeloma and Colorectal Cancer From Systems Immunology to Single Cells Leo Hansmann Mark M. Davis Lab Department of Microbiology&Immunology Stanford University Multiple Myeloma Monoclonal disease
More informationHistopathologic results
Self evaluation 1 Clinical Case 55-year-old woman Bilateral enlargement of cervical, axillary and inguinal lymph nodes, largest diameter > 6 cm Hepatosplenomegaly. Enlargement of retroperitoneal, mesenteric
More informationPROGNOSIS IN ACUTE LYMPHOBLASTIC LEUKEMIA PROGNOSIS IN ACUTE MYELOID LEUKEMIA
PROGNOSIS IN ACUTE LYMPHOBLASTIC LEUKEMIA UNFAVORABLE Advanced age High leukocyte count at diagnosis Presence of myeloid antigens Late achievement of CR Chromosomal abnormalities: t(9:22)(q34:q11) t(4;11)(q21;q23)
More informationCharacteristics and Prognosis of Patients with Richter s Transformation of Chronic Lymphocytic Leukemia: Experience with FDG/PET
Characteristics and Prognosis of Patients with Richter s Transformation of Chronic Lymphocytic Leukemia: Experience with FDG/PET Lorenzo Falchi, Long Trinh, Edith M Marom, Mylene Truong, Ellen J Schlette,
More informationUnderstanding the biology of CLL in the light of newer technologies. Richard Rosenquist, MD, PhD Uppsala University Sweden
Understanding the biology of CLL in the light of newer technologies Richard Rosenquist, MD, PhD Uppsala University Sweden Genetic milestones in CLL G-banding CLL-FISH Microarrays Subclonal heterogeneity
More informationMature B- and T-Cell Lymphoproliferative Neoplasms
CHAPTER Mature B- and T-Cell Lymphoproliferative Neoplasms Chronic Lymphoproliferative Neoplasms 475 Kathryn Foucar, MD [22.2] Chronic Lymphocytic Leukemia 476 [22.3] B-Cell Prolymphocytic Leukemia 491
More informationHaematological Malignancies
New Developments in Chronic Lymphocytic Leukaemia Diagnosis Julio Delgado, Rodrigo Santacruz, Tycho Baumann, and Emili Montserrat Department of Hematology, Institute of Hematology and Oncology, Hospital
More informationChromosome 6 Abnormalities Associated with Prolymphocytic Acceleration in Chronic Lymphocytic Leukemia* f
ANNALS OF CLINICAL AND LABORATORY SCIENCE, Vol. 28, No. 1 Copyright 1998, Institute for Clinical Science, Inc. Chromosome 6 Abnormalities Associated with Prolymphocytic Acceleration in Chronic Lymphocytic
More informationSupplementary appendix
Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Farooqui MZH, Valdez J, Martyr S, et al. Ibrutinib
More informationImmunohistochemical classification of malignant lymphomas
Immunohistochemical classification of malignant lymphomas Prof. Mogens Vyberg NordiQC Institute of Pathology Aalborg, Denmark Thanks to Jan Klos Important issues Distinction from non-hematopoietic neoplasms
More informationFastTest. You ve read the book... ... now test yourself
FastTest You ve read the book...... now test yourself To ensure you have learned the key points that will improve your patient care, read the authors questions below. Please refer back to relevant sections
More informationEmerging New Prognostic Scoring Systems in Myelodysplastic Syndromes 2012
Emerging New Prognostic Scoring Systems in Myelodysplastic Syndromes 2012 Arjan A. van de Loosdrecht, MD, PhD Department of Hematology VU University Medical Center VU-Institute of Cancer and Immunology
More informationA 32 year old woman comes to your clinic with neck masses for the last several weeks. Masses are discrete, non matted, firm and rubbery on
A 32 year old woman comes to your clinic with neck masses for the last several weeks. Masses are discrete, non matted, firm and rubbery on examination. She also has fever, weight loss, and sweats. What
More informationEU Media Inquiries: Satu Kaarina Glawe Phone: +49 (0) 2638 947 9218 Mobile: +49 (172) 294 6264 Email: sglawe@its.jnj.com
EU Media Inquiries: Satu Kaarina Glawe Phone: +49 (0) 2638 947 9218 Mobile: +49 (172) 294 6264 Email: sglawe@its.jnj.com Investor Relations: Stan Panasewicz Phone: +1 732-524-2524 Louise Mehrotra Phone:
More informationWhat is Cancer? Cancer is a genetic disease: Cancer typically involves a change in gene expression/function:
Cancer is a genetic disease: Inherited cancer Sporadic cancer What is Cancer? Cancer typically involves a change in gene expression/function: Qualitative change Quantitative change Any cancer causing genetic
More informationChallenging Diagnosis in Hematopathology
Challenging Diagnosis in Hematopathology S. David Hudnall, M.D. Professor of Pathology & Laboratory Medicine Chief, Division of Hematopathology Yale University School of Medicine dhudnall@yale.edu Challenging
More informationCD5-positive, Small B-Cell Lymphoproliferative Disorders: Aberrant Findings of CLL/SLL and MCL
North American Journal of Medicine and Science Oct 2010 Vol 3 No.4 181 CD5-positive, Small B-Cell Lymphoproliferative Disorders: Aberrant Findings of CLL/SLL and MCL Youjun Hu, MD, Marc Golightly, PhD
More informationUpdate in Hematology Oncology Targeted Therapies. Mark Holguin
Update in Hematology Oncology Targeted Therapies Mark Holguin 25 years ago Why I chose oncology People How to help people with possibly the most difficult thing they may have to deal with Science Turning
More informationHematopathology VII Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia, And Hairy Cell Leukemia
John L. Kennedy, M.D. UIC College of Medicine Associate Professor of Clinical Pathology M2 Pathology Course Lead Pathologist, VA Chicago Health Care System Lecture #43 Phone: (312) 569-6690 Thursday, November
More informationLymphoma is a neoplasm with a clonal expansion of
New Immunohistochemistry for B-Cell Lymphoma and Hodgkin Lymphoma Xiaohong (Mary) Zhang, MD, PhD; Nadine Aguilera, MD Context. B-cell non-hodgkin lymphoma is a heterogeneous group of lymphoproliferative
More informationHodgkin Lymphoma Disease Specific Biology and Treatment Options. John Kuruvilla
Hodgkin Lymphoma Disease Specific Biology and Treatment Options John Kuruvilla My Disclaimer This is where I work Objectives Pathobiology what makes HL different Diagnosis Staging Treatment Philosophy
More informationNon Hodgkin Lymphoma:
Non Hodgkin Lymphoma: Non Hodgkin Lymphoma, often referred to as NHL, is a cancer originating in the lymphocytes, a type of blood cell, which are integral to the body s immune system. Non Hodgkin Lymphoma
More informationMolecular pathogenesis of chronic lymphocytic leukemia
Review series Molecular pathogenesis of chronic lymphocytic leukemia Gianluca Gaidano, 1 Robin Foà, 2 and Riccardo Dalla-Favera 3,4,5,6 1 Division of Hematology, Department of Translational Medicine, Amedeo
More informationNGS e malattie mieloproliferative
NGS e malattie mieloproliferative Matteo G Della Porta Department of Hematology Oncology, Fondazione IRCCS Policlinico S. Matteo, University of Pavia Medical School, Pavia, Italy matteo@haematologica.org
More informationEstimated New Cases of Leukemia, Lymphoma, Myeloma 2014
ABOUT BLOOD CANCERS Leukemia, Hodgkin lymphoma (HL), non-hodgkin lymphoma (NHL), myeloma, myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs) are types of cancer that can affect the
More informationLymphoid Neoplasms. Sylvie Freeman Department of Clinical Immunology, University of Birmingham
Lymphoid Neoplasms Sylvie Freeman Department of Clinical Immunology, University of Birmingham Incidence of Haematological Malignancies UK2001 (CRUK) Malignancy New Cases All Cancers 271,000 Leukaemia 6,760
More informationMonoclonal Gammopathy of Undetermined Significance (MGUS) Facts
Monoclonal Gammopathy of Undetermined Significance (MGUS) Facts Normal plasma cells (a type of white blood cell) produce antibodies (also known as immunoglobulins) which help fight infection. Each type
More information6/3/2013. Follicular and Other Slow Growing Lymphomas. Stephen Ansell, MD, PhD Mayo Clinic
Follicular and Other Slow Growing Lymphomas Stephen Ansell, MD, PhD Mayo Clinic 1 Learning Objectives Start with an overview of Follicular and other slow growing lymphomas Discuss current and emerging
More informationLauren Berger: Why is it so important for patients to get an accurate diagnosis of their blood cancer subtype?
Hello, I m Lauren Berger and I m the Senior Director of Patient Services Programs at The Leukemia & Lymphoma Society. I m pleased to welcome Dr. Rebecca Elstrom. Dr. Elstrom is an Assistant Professor in
More informationUNDERSTANDING MULTIPLE MYELOMA AND LABORATORY VALUES Benjamin Parsons, DO bmparson@gundersenhealth.org Gundersen Health System Center for Cancer and
UNDERSTANDING MULTIPLE MYELOMA AND LABORATORY VALUES Benjamin Parsons, DO bmparson@gundersenhealth.org Gundersen Health System Center for Cancer and Blood Disorders La Crosse, WI UNDERSTANDING MULTIPLE
More informationCAR T cell therapy for lymphomas
CAR T cell therapy for lymphomas Sattva S. Neelapu, MD Associate Professor and Deputy Chair ad interim Department of Lymphoma and Myeloma UT MD Anderson Cancer Center, Houston, TX CAR T cell therapy What
More informationPROTOCOLS FOR TREATMENT OF MALIGNANT LYMPHOMA
2012 1 31,, PROTOCOLS FOR TREATMENT OF MALIGNANT LYMPHOMA Version 1.0 2012 DIVISION OF HAEMATOLOGY / ONCOLOGY DEPARTMENT OF MEDICINE KAOHSING VETERAN GENERAL HOSPTIAL General Guide Diagnosis 1.Adequate
More informationSWOG ONCOLOGY RESEARCH PROFESSIONAL (ORP) MANUAL VOLUME I RESPONSE ASSESSMENT LEUKEMIA CHAPTER 11A REVISED: OCTOBER 2015
LEUKEMIA Response in Acute Myeloid Leukemia (AML) Response criteria in Acute Myeloid Leukemia for SWOG protocols is based on the review article Diagnosis and management of acute myeloid leukemia in adults:
More informationBAP1 germline mutations A new Cutaneous Nevus Melanoma Syndrome. Thomas Wiesner
BAP1 germline mutations A new Cutaneous Nevus Melanoma Syndrome Thomas Wiesner Disclosure Listed as co-inventor US patent application US 61/463,389 BAP1 mutational analysis in determining susceptibility
More informationHodgkin and Non-Hodgkin Lymphoma Pre-HCT Data
(Form 2018) This section of the CIBMTR Forms Instruction Manual is intended to be a resource for completing the Hodgkin and Non-Hodgkin Lymphoma Pre-HCT Data Form. E-mail comments regarding the content
More informationCHRONIC LYMPHOCYTIC LEUKEMIA
CHRONIC LYMPHOCYTIC LEUKEMIA Executive Summary Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the Western world, but is significantly less frequent in Asia. The median age of
More informationImmunophenotyping in the differential diagnosis of histologically low grade B cell lymphomas
Current Diagnostic Pathology (2000) 6, 55 63 2000 Harcourt Publishers Ltd doi:10.1054/cdip.2000.0015, available online at http://www.idealibrary.com on REVIEW Immunophenotyping in the differential diagnosis
More informationNovità dall EHA >> [ Leucemia linfatica cronica ]
Novità dall EHA >> [ Leucemia linfatica cronica ] Relatore: P. GHIA 27-28 ottobre 2008 Borgo S. Luigi Monteriggioni (Siena) Leucemia linfatica cronica - Copyright FSE 1 Number and type of abstracts 2 Number
More informationAdult Medical-Surgical Nursing H A E M A T O L O G Y M O D U L E : L E U K A E M I A 2
Adult Medical-Surgical Nursing H A E M A T O L O G Y M O D U L E : L E U K A E M I A 2 Leukaemia: Description A group of malignant disorders affecting: White blood cells (lymphocytes or leucocytes) Bone
More informationMULTIPLE MYELOMA 1 PLASMA CELL DISORDERS Multiple l Myeloma Monoclonal Gammopathy of Undetermined Significance (MGUS) Smoldering Multiple Myeloma (SMM) Solitary Plasmacytoma Waldenstrom s Macroglobulinemia
More informationSomething Old, Something New.
Something Old, Something New. Michelle A. Fajardo, D.O. Loma Linda University Medical Center Clinical Presentation 6 year old boy, presented with hematuria Renal mass demonstrated by ultrasound & CT scan
More informationSubclassifying DLBCL. Diffuse Large B-Cell Lymphoma: Variants & Subtypes. Subclassifying DLBCL
Diffuse Large B-Cell Lymphoma: Variants & Subtypes Patrick Treseler, MD, PhD University of California San Francisco Subclassifying DLBCL An Entity in Search of a Meaningful Classification Subclassifying
More informationDELPHI 27 V 2016 CYTOMETRY STRATEGIES IN THE DIAGNOSIS OF HEMATOLOGICAL DISEASES
DELPHI 27 V 2016 CYTOMETRY STRATEGIES IN THE DIAGNOSIS OF HEMATOLOGICAL DISEASES CLAUDIO ORTOLANI UNIVERSITY OF URBINO - ITALY SUN TZU (544 b.c. 496 b.c) SUN TZU (544 b.c. 496 b.c.) THE ART OF CYTOMETRY
More informationfor Leucocyte Immunophenotyping Leukaemia Diagnosis Interpretation All Participants Date Issued: 08-September-2014 Closing Date: 26-September-2014
for Leucocyte Immunophenotyping Leukaemia Interpretation All Participants Participant: 4xxxx Trial No: 141502 Date Issued: 08-September-2014 Closing Date: 26-September-2014 Trial Comments This was an electronic
More informationMultiple Myeloma Patient s Booklet
1E Kent Ridge Road NUHS Tower Block, Level 7 Singapore 119228 Email : ncis@nuhs.edu.sg Website : www.ncis.com.sg LIKE US ON FACEBOOK www.facebook.com/ nationaluniversitycancerinstitutesingapore Multiple
More informationAcute leukemias and myeloproliferative neoplasms
Acute leukemias and myeloproliferative neoplasms GERGELY SZOMBATH SEMMELWEIS UNIVERSITY OF MEDICINE IIIRD. DEPARTMENT OF INTERNAL MEDICINE Basics of acute leukemia Neoplastic disease Cell of origin is
More informationSIGNALING PATHWAYS COME TARGET TERAPEUTICO NEI LINFOMI
SIGNALING PATHWAYS COME TARGET TERAPEUTICO NEI LINFOMI Davide Rossi, M.D., Ph.D Division of Hematology Department of TranslaDonal Medicine Amedeo Avogadro University of Eastern Piedmont Novara- Italy 2010:
More informationActivation and effector functions of HMI
Activation and effector functions of HMI Hathairat Thananchai, DPhil Department of Microbiology Faculty of Medicine Chiang Mai University 25 August 2015 ว ตถ ประสงค หล งจากช วโมงบรรยายน แล วน กศ กษาสามารถ
More informationSubtypes of AML follow branches of myeloid development, making the FAB classificaoon relaovely simple to understand.
1 2 3 4 The FAB assigns a cut off of 30% blasts to define AML and relies predominantly on morphology and cytochemical stains (MPO, Sudan Black, and NSE which will be discussed later). Subtypes of AML follow
More informationInteresting Case Series. Periorbital Richter Syndrome
Interesting Case Series Periorbital Richter Syndrome MarkGorman,MRCS,MSc, a Julia Ruston, MRCS, b and Sarath Vennam, BMBS a a Division of Plastic Surgery, Royal Devon and Exeter Hospital, Exeter, Devon,
More informationNew Targets and Treatments for Follicular Lymphoma. Disclosures
Winship Cancer Institute of Emory University New Targets and Treatments for Follicular Lymphoma Jonathon B. Cohen, MD, MS Assistant Professor Div of BMT, Emory University Disclosures Consulting fees from:
More informationSpecial report. Chronic Lymphocytic Leukemia (CLL) Genomic Biology 3020 April 20, 2006
Special report Chronic Lymphocytic Leukemia (CLL) Genomic Biology 3020 April 20, 2006 Gene And Protein The gene that causes the mutation is CCND1 and the protein NP_444284 The mutation deals with the cell
More information6/20/2014. PART I: Plasma Cell Myeloma. Plasma Cells
MULTIPLE MYELOMA: THE TESTING, VALIDATION AND IMPLEMENTATION OF CELL SEPARATION TECHNOLOGY FOR IMPROVED PATIENT CARE Elizabeth Harper CG(ASCP), Binh Vo CG(ASCP), Joey Pena CG(ASCP), Denise Lovshe CG(ASCP),
More informationSocial inequalities impacts of care management and survival in patients with non-hodgkin lymphomas (ISO-LYMPH)
Session 3 : Epidemiology and public health Social inequalities impacts of care management and survival in patients with non-hodgkin lymphomas (ISO-LYMPH) Le Guyader-Peyrou Sandra Bergonie Institut Context:
More informationTwo Retroperitoneal Low-Grade B-Cell Lymphoma Successfully Treated With a Combination of Chimeric Anti-CD20 Monoclonal Antibody and CHOP Chemotherapy
Two Retroperitoneal Low-Grade B-Cell Lymphoma Successfully Treated With a Combination of Chimeric Anti-CD20 Monoclonal Antibody and CHOP Chemotherapy Yoichi Kitamura, MD Kazuhiko Hayashi, MD Kazumi Uchida,
More informationUpdate on Follicular Lymphoma. Brad Kahl, M.D.
Update on Follicular Lymphoma Brad Kahl, M.D. Follicular Lymphoma: 25% of NHL Cases Other subtypes (9%) T and NK cell (12%) Burkitt (2.5%) Diffuse large B cell (DLBCL) (30%) Mantle cell (6%) Follicular
More informationLenalidomide (LEN) in Patients with Transformed Lymphoma: Results From a Large International Phase II Study (NHL-003)
Lenalidomide (LEN) in Patients with Transformed Lymphoma: Results From a Large International Phase II Study (NHL-003) Reeder CB et al. Proc ASCO 2010;Abstract 8037. Introduction > Patients (pts) with low-grade
More informationTargeted Therapy What the Surgeon Needs to Know
Targeted Therapy What the Surgeon Needs to Know AATS Focus in Thoracic Surgery 2014 David R. Jones, M.D. Professor & Chief, Thoracic Surgery Memorial Sloan Kettering Cancer Center I have no disclosures
More informationConflict of Interest. Overdiagnosis. Beyond Bethesda: Challenges with Indeterminate Thyroid Aspirates 4/17/2015. Jeffrey F.
Beyond Bethesda: Challenges with Indeterminate Thyroid Aspirates Jeffrey F. Krane, MD PhD Associate Professor of Pathology Harvard Medical School Chief, Head and Neck Pathology Service Associate Director,
More informationBRAF in the diagnostic evaluation of thyroid nodules
Symposium 13 Molecular markers in thyroid cancer: current role in clinical practice BRAF in the diagnostic evaluation of thyroid nodules Laura Fugazzola University of Milan, Italy Papillary carcinoma BRAF
More informationWhat is non-hodgkin lymphoma, how is it treated, and what is the unmet need?
What is non-hodgkin lymphoma, how is it treated, and what is the unmet need? Tim Illidge BSc PhD MRCP FRCR FRCPath Institute of Cancer Sciences, University of Manchester Manchester Cancer Research Centre,
More informationUtility of flow cytometric κ and λ light chain analysis of peripheral blood
JBUON 2015; 20(5): 1322-1326 ISSN: 1107-0625, online ISSN: 2241-6293 www.jbuon.com E-mail: editorial_office@jbuon.com ORIGINAL ARTICLE Utility of flow cytometric κ and λ light chain analysis of peripheral
More informationCorporate Medical Policy
Corporate Medical Policy Hematopoietic Stem-Cell Transplantation for CLL and SLL File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem-cell_transplantation_for_cll_and_sll
More information