L-Tryptophan Current Prospects in Medicine and Drug Safety
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1 L-Tryptophan Current Prospects in Medicine and Drug Safety Editors Walter Kochen Hans Steinhart W DE G Walter de Gruyter Berlin New York 1994
2 Contents Parti Tryptophan Metabolism, Specific Neurotoxic Effects of Metabolites, Relation to Nutrition, Mood and Behavior, Toxicity and Therapeutical Applications The Tryptophan Case: An Overview 3 Thomas Simat, Hans Steinhart and Walter Kochen (Germany) Tryptophan Metabolism: A Review 17 Raymond R. Brown (USA) Tryptophan Binding to a Nuclear Membrane Receptor 31 Herschel Sidransky, Rabinder N. Kurl, Ethel Verney, James W.Cosgrove and Arnold M. Schwartz (USA) The Effect of Tryptophan Availability on Mood and Behavior 40 Simon N. Young (Canada) Sleep-Inducing Effects of L-Tryptophan 63 Goran Hajak, Andrea Rodenbeck and Eckart Riither (Germany) Are Tryptophan Supplements Needed in Low-Protein Diets? 84 Norbert Gretz and Manfred Strauch (Germany) Immune Stimulation, in Patients with Human Immunodeficiency. Virus Infection Correlates with Tryptophan Degradation and with Neuropsychiatric Abnormalities 91 Dietmar Fuchs, Arnulf A. Moller, Giinther Weiss, Gabriele Werner-Felmayer, Manfred P. Dierich and Helmut Wachter (Austria) Picolonic Acid and its Influence on the Immune System 99 Luigi Varesio, A. Soleti, D. Radzioch, K. Pulkki, A. Brooks, G.L. Gusella, M.C. Bosco and G. Forni (USA)
3 vm Effect of Tryptophan Administration on Circulating Tryptophan Metabolites 111 Gerald Huether (Germany) Tryptophan, Serotonin, Food-Intake, and Obesity 130 Richard J. Wurtman (USA) CSF Tryptophan in Inflammatory Neurological Diseases 139 Lothar Demisch, Margit Proescholdt, Melanie Ott, Wolfgang Engelhardt, Horst Baas, Wolfgang Enzenberger and Peter A. Fischer (Germany) Individual Day-to-Day Variations of Plasma Amino Acid Levels in Healthy Volunteers 150 Joachim Demling, Klaus Langer, Michael Worthmiiller and Vera Yusufu (Germany) The Influence of Kynurenine, Neopterin and Pyridoxal-5-Phosphate on Cholesterol Content and Phospholipid Biosynthesis in Vitro 165 Vera Rudzite, Edite Jurika, Dietmar Fuchs, Gilbert Reibnegger and Helmut Wachter (Latvia) The Influence of Tryptophan and Nicotinamide on Acetaminophenon. Hepatotoxicity in Mice Potentiated by Ethanol and on Adjuvans Arthritis in Rats 171 Hans Kroger and Wilhelm Ehrlich (Germany) L-Tryptophan: A Therapeutic and Experimental Tool in Depressive Disorders 179 Svend E. M0ller (Denmark) Serotonin Precursors in Refractory Depression 195 Donald Eccleston (UK) L-Tryptophan Toxicology: A Review 200 Manfred Herbst (Germany) Part 2 Eosinophilia-Myalgia Syndrome and Tryptophan Eosinophilia-Myalgia Syndrome: An Epidemiologic Report on Germany 215 Lisa Carr, Hendrik Lehnert and Eckart Riither (Germany)
4 Pathology of the Microangiopathy and Immunohistochemistry of the Inflammatory Infiltrate in Eosinophilia-Myalgia Syndrome 223 Stephan A. Smith (USA) Evidence for a Pathogenetic Role for Cytokines in the Eosinophilia- Myalgia Syndrome 234 Lindsey A. Criswell (USA) Interleukin-5 Activity in Tryptophan Associated Eosinophilia- Myalgia Syndrome 250 William F. Owen (USA) Altered Tryptophan Metabolism and Immune Parameters in Eosinophilia-Myalgia Syndrome 255 Raymond R. Brown, PL. Fisette, R.A. Arend and Y. Ozaki (USA) High Frequency of Antibodies to Nucleoli and 5-Hydroxytryptamin (Serotonin) in Patients with Primary Fibromyalgia Syndrome and Eosinophilia-Myalgia Syndrome 263 Reinhild Klein and Peter A. Berg (Germany) Therapeutic Aspects in the Eosinophilia-Myalgia Syndrome 276 Hendrik Lehnert, Peter A. Berg, Eckart Riither and Svend E. M0ller (Germany) Toxic Oil Syndrome - Erythro-Myalgia Syndrome 284 Roy Goulding (UK) IX Part 3 Analytics in Manufacturing L-Tryptophan, New Analytical Aspects and Drug Safety / Study of Mechanism of Peak E Substance of L-Tryptophan 295 Kazunori Sakimoto and Yasushi Torigoe (Japan) Industrial Quality Control of L-Tryptophan. A Statement for Germany 312 Jiirgen Malinka (Germany) Characterisation of By-Products in L-Tryptophan 328 Kurt Giinther and Bernd Hoppe (Germany)
5 Opportunities and Limitations of Modern TLC/HPTLC in the Quality Control of L-Tryptophan. 338 Hellmut Jork and Jutta Ganz (Germany) Higher-Order Derivative Spectrophotometry - an Excellent Tool for the Deconvolution of Superposed Signals: Application to Analysis of L-Tryptophan 351 Gerhard Talsky, Xiashi Zhu and Johannes Hintermayer (Germany) Quality Control of Peptides and Proteins by Mass Spectrometry 362 Wolf D. Lehmann and Michael Karas (Germany) Some Laser Photothermal Methods and their Potentiality for Quality Assessment of Tryptophan 383 Dane Bicanic, Mladen Franko, Henk Jalink and Chieu Tran (The Netherlands) Process Changes and their Impacts on the Product Quality of Glycoproteins 412 Rolf G. Werner, Helmut Hoffmann, Stefan Bassarab and Michael Schliiter (Germany) Immunotoxicological Screening of Biotechnology Products 429 Eric J. de Waal, H. van Loveren, H.J.M. van de Donk, C.F. van Kreijl and J.G. Vos (The Netherlands) What can we Learn from the Tryptophan Disaster? Proposal of a New Strategy in Drug Safety 434 Walter Kochen, Hans Steinhart, Jiirgen Malinka and Thomas Simat (Germany) Author Index 451 Subject Index 453
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