PHARMACOLOGY OF VNS VARIANT 1 1) Anti-ChEs: contraindications and precautions. 2) Examples of Cholinesterase reactivators. 3) Cholinoblockers-natural
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1 VARIANT 1 Anti-ChEs: contraindications and precautions. Examples of Cholinesterase reactivators. Cholinoblockers-natural alkaloids (examples). 4) GIT-effects of Atropine. 5) Pharmacologic characteristic of Tropicamide. 6) Examples of Nicotine-containing drugs. 7) Steps in the synthesis of catecholomines. 8) Metabolic effects of Epinephrine. 9) Adrenergic drugs-bronchodilatators (examples). 10) Mechanism of action of Dobutamine. 1 Uses of Phenylephrine. 1 Central uses of adrenergic agonists. 1 Alfa-2-selective adrenoblockers (examples). 14) Tamsulosin: pharmacological group, mechanism of action, clinical uses. 15) Examples of Alfa1,- Betа-аdrenoblockers.
2 VARIANT 2 Pulmonary effects of Atropine. Group of Atropine: quaternary compounds (properties and examples). Clinical uses of Atropine group. 4) Symptoms of Atropine toxicity. 5) Ganglion blocking drugs (competitive blockers) examples. 6) Location of α1-receptors. 7) Preparations (drug forms) of Epinephrine. 8) Adrenergic drugs-nasal decongestants (examples). 9) Treatment of Amphetamine toxicity. 10) Examples of Selective beta-2-stimulants. 1 General pharmacological effects of alfa-blockers. 1 Uses of Tolazoline.
3 VARIANT 3 Selective (relatively) M1-receptor antagonists (Two drugs) and their clinical uses. Ophthalmologic effects of cholinomimetics. Uses of Cholinomimetics. 4) Symptoms of Anticholinesterase poisoning. 5) Cholinoblockers-bronchodilatators, only for inhalation (examples). 6) Glands effects of Atropine. 7) Pharmacological effects of Pirenzepine. 8) Examples of selective nicotinic agonists. 9) Vascular effects of Epinephrine. 10) Fill the table: Action of Epinephrine on aqueous humor dynamics Receptor Agonist action α1 α2 β2 1 Negative effects of Epinephrine. 1 Adrenergic drugs-cns-stimulants (examples). 1 Pharmacological effects of Dopamine. 14) Directions of clinical uses of adrenergic agonists. 15) Uses of alfa-adrenoblockers.
4 VARIANT 4 Physiologic role of M1-receptors. Sources of Pilocarpine. Fill the table: Nerve gases for chemical warfare 4) Cholinergic agents for treatment of Alzheimer disease (three drugs). 5) Uses of Cholinesterase reactivators. 6) CNS-effects of Atropine. 7) Body temperature and Atropine. 8) Treatment of Atropine toxicity. 9) Location of α2-receptors. 10) Eye-effects of Epinephrine. 1 Clinical uses of Epinephrine. 1 Adrenergic drugs-anorectics (examples). 1 Mechanism of action of Ephedrine. 14) Side effects of Selective beta-2-stimulants. 15) Cardioselective adrenoblockers without intrinsic sympathomimetic activity (examples).
5 VARIANT 5 Location of subtypes nicotinic receptor. N n N m Location Drug forms of Pilocarpine. Uses of Donepezil. 4) Treatment of Anticholinesterase poisoning. 5) Heart effects of Atropine. 6) Sources of Atropine. 7) Mechanism of action of Pirenzepine. 8) Atropine group: contraindications. 9) Ganglion blocking drugs (competitive blockers) clinical uses. 10) Location of β2-receptors. 1 Epinephrine: skeletal muscle effects. 1 Clinical uses of Dopamine. 1 Mechanism of Ephedrine-induced tachyphylaxis. 14) Nasal decongestants: examples, mechanism of action and pharmacological effects. 15) Cardioselective adrenoblockers with additional vasodilatator activity (examples).
6 VARIANT 6 Cholinergic agonists: Choline esters Alkaloids 4) Eye effects of Pilocarpine. Duration of this effects after instillation. Fill the table: Physostigmine Neostigmine Source Chemistry Level of oral absorption CNS actions Applied to eye Direct action on Nm cholinoreceptors Prominent effect on 4) Ophthalmologic effects of Atropine. 5) Pharmacokinetics of Atropine. 6) Clinical uses of Pirenzepine. 7) Drug forms of Tropicamide (preparations). 8) Clinical uses of Nicotine-containing drugs. 9) Cardiac effects of Epinephrine. 10) CNS-effects of Epinephrine. 1 Epinephrine: contraindications. 1 Adrenergic anorectic drugs: examples, mechanism of action and pharmacological effects. 1 Prazosine: pharmacological group, mechanism of action, clinical uses. 14) Examples of nonselective adrenoblockers with additional vasodilatator activity.
7 VARIANT 7 Eye effects of Pilocarpine. Duration of this effects after instillation. Atropine: contraindications. Scopolamine: specific of therapeutic uses. 4) Cardiac effects of cholinomimetics. 5) Mechanism of action of Dopamine. 6) Clinical uses of Dobutamine. 7) Sources of Ephedrine. 8) Why Ephedrine it is effective at oral use? 9) Central effects of Ephedrine. 10) Adrenergic CNS stimulants: examples, pharmacological effects, negative effects. 1 Mechanism of action of Phenylephrine. 1 Pharmacological effects of Selective beta-2-stimulants. 1 Cardiac uses of adrenergic agonists. 14) Groups of the drugs for treatment glaucoma.
8 VARIANT 8 Location of subtypes muscarinic receptor. M1 M2 M3 Location Heart effects of cholinomimetics. Uses of Rivastigmine. 4) Alfa-1-selective blockers (examples). 5) Phentolamine: pharmacological group, mechanism of action, clinical uses. 6) Examples of nonselective adrenoblockers with intrinsic sympathomimetic activity. 7) Vascular effects of beta-adrenoblockers. 8) Uterus effects of beta-adrenoblockers. 9) Adverse effects of beta-adrenoblockers. 10) Adrenoblockers: drugs interactions. 1 Pharmacological properties of beta-1-adrenoblockers. 1 Means of intrinsic sympathomimetic activity. 1 Pharmacologic characteristic of Sotalol.
9 VARIANT 9 Location and functions of M4 and M5 cholinoreceptors. Vessels effects of cholinomimetics. Fill the table: Reversible carbamates anticholinesterases 4) 5) 6) 7) 4) Cholinoblockers-semisynthetic derivatives. 5) Examples of hydrogenated ergot alkaloids. 6) Pharmacological group of Tolazoline. 7) Examples of nonselective adrenoblockers without intrinsic sympathomimetic activity. 8) Fill the table: Beta-adrenoblockers Fist generation Second generation Third generation 4) 4) 5) 9) Cardiac effects of beta-adrenoblockers. 10) Clinical uses of Adrenoblockers. 1 Pharmacologic characteristic of Carvedilol. 1 Topical Beta-adrenoblockers for Glaucoma (mechanism of hypotensive effect, examples of the drugs). 1 Carbonic anhydrase inhibitors as antiglaucomic agents (mechanism of hypotensive effect, examples of the drugs). 4)
10 ADRENOBLOCKERS Beta-1, Beta-2 (Nonselective) Beta-1 (Cardioselective) Without intrinsic sympathomimetic activity Propranolol Nadolol Sotalol Timolol Chloranolol Metipranolol Atenolol Metoprolol Betaxolol Bisoprolol Esmolol Proctolol Talinolol With intrinsic Pindolol Acebutalol sympathomimetic activity Oxprenolol Penbutalol Bopindolol Alprenolol With additional vasodilatator activity Dilevalol Bucindolol Celiprolol Nebivolol Pindolol Carteolol (+ISA) Alfa1,- Betа-аdrenoblockers Nonselective Labetalol, Carvedilol, Proxodolol
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