it will set at body temperature, and it will grow. UNIQUE FORMULATIONS

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1 BETTER BONE GRAFT FORMULATION. SUPERIOR BONE GRAFT HANDLING.

2 When choosing a Demineralized Bone Matrix, remember that not all products are created equal. For excellent clinical performance and patient results, it s the quality of bone and its ability to perform that matter. With bone graft substitutes from Keystone Dental, our product is ready, it will set at body temperature, and it will grow. Well-tested bone grafting products offering maximum performance with simplicity of UNIQUE FORMULATIONS Our DBM products feature a unique formulation that incorporates stringently processed human cortical bone and a proprietary temperature-responsive, biocompatible carrier. PROVEN OSTEOINDUCTIVITY Unlike some other manufacturers, each lot of Keystone Dental DBM is rigorously tested to confirm that it contains the level of osteoinductivity to form new bone. SUPERIOR HANDLING All of our DBM products incorporate a biocompatible Reverse Phase Medium (RPM) that renders them highly malleable and easy to handle, mold or pack into any defect.

3 Demineralized Bone Matrix with Cancellous Bone Paste DynaBlast is a composite graft product that combines osteoinductive and osteoconductive elements in a proprietary, reverse phase medium. This powerful 2-in-1 solution combines: Demineralized bone, which stimulates new bone growth, and Cancellous chips, which provide a natural structural scaffold to encourage the attachment of osteogenic precursor cells Available in both putty and paste, DynaBlast can be used either alone or as a bone graft extender indicated for augmentation or reconstructive treatment of the alveolar ridge. Putty use. DYNABLAST PASTE IN AN EXTRACTION SOCKET. DYNABLAST PUTTY USED WITH AN IMPLANT WITH BUCCAL DEHISCENCE. EXCELLENT GRAFT CONTAINMENT Our DBM products thicken at body temperature and resist irrigation, minimizing the likelihood of migration from the surgical site. READY-TO-USE APPLICATION All of our DBM products are available for immediate use with no refrigeration, thawing, mixing or other preparation needed. CLINICAL DEFECT DYNABLAST DYNAGRAFT D Extraction sockets Periodontal defects Implant dehiscence defects Moderate localized ridge defects Sinus floor augmentation Implant site development Coronal defects around immediate implants Paste only Gel only

4 Not just products that perform. Products that perform safely. DONOR SELECTION AND SCREENING The medical and social history of potential tissue donors is rigorously screened to ensure the suitability of potential donors. Each lot of bone is obtained from a single human donor and is not pooled with other donors. We obtain tissue only from those suppliers that comply with all tissue banking standards as provided by the Food and Drug Administration (FDA), the Amercian Association of Tissue Banks (AATB), and the Clinical Laboratory Improvement Amendments (CLIA). UNPARALLELED TESTING Every lot of DBM used in Keystone Dental s allografts has been thoroughly tested in a quantitative in vitro assay to ensure its osteoinductive properties. Our allografts must 2000 yield an alkaline phosphatase level significantly higher than the established industry baseline. BMP DBM Days Extract Cells Alkaline Phosphatase Units Alkaline phosphatase is an enzyme that serves as an indicator Muscle cells C 2 C 12 Osteoblast-like Cells DBM SAMPLE # for osteoblastic activity. Single donor lots are the only lots Keystone Dental produces. GRAFT PROCESSING AND STERILIZATION Allografts are produced in HEPA filtered clean rooms with environmentally and microbiologically monitored air. Sterilization is achieved through electron beam (e-beam) irradiation after packaging to destroy any microorganisms without negatively affecting the bioactivity of our DBM products.

5 Osteoinductive Dental Bone Graft Substitute DynaGraft D is a unique graft substitute composed of a high content of human Demineralized Bone Matrix (DBM) in a reverse phase medium that is designed to stimulate natural bone formation. Available in putty or gel form, DynaGraft D can be used either alone or as a bone graft extender indicated for augmentation or reconstructive treatment of the alveolar ridge. Gel Putty DYNAGRAFT D GEL IN AN EXTRACTION SOCKET IN CONJUNCTION WITH IMMEDIATE IMPLANT PLACEMENT. RABBIT ULNA DEFECT TREATED WITH DYNAGRAFT D GEL 6 WEEKS 12 WEEKS Images at 100X magnification. Photo micrographs at 6 and 12 weeks showing new bone formation on demineralized bone matrix graft.

6 Ordering Information DynaBlast Demineralized Bone Matrix with Cancellous Bone Putty (in vial) cc cc cc DynaGraft D Osteoinductive Dental Bone Graft Substitute Putty (in vial) cc cc cc Paste (in syringe) cc cc cc Gel (in syringe) cc cc cc! Consult the package inserts for information on indications, contraindications, warnings, cautions and use. Keystone Dental, Inc. is an oral healthcare medical device company headquartered in Boston, Massachusetts. Founded in March 2006, Keystone is focused on developing and marketing a comprehensive range of dental products and services for the tooth replacement market. Our mission is to provide innovative, safe, efficacious, and cost-effective solutions for tooth replacement therapy, with patient care as our first and ultimate responsibility. Keystone aspires to build a market leading, global brand recognized within the dental community for its integrity, trust, and commitment to improving the standard of care for patients and their quality of life. For ordering information please contact us at or visit us at RevA