GMP - designed Maintenance-free Diaphragm valve made of forged stainless steel according to ASME BPE-2002 and investment casting

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1 type series booklet /13-10 GMP - designed Maintenance-free Diaphragm valve made of forged stainless steel according to ASME BPE-2002 and investment casting with Buttweld ends or clamps PN 10 size range 1/4-4 Fields of application Biotechnology, sterile process technology, food and pharmaceutical industry. Operating data - Operating temperature range from -10 C (-22 F) up to +160 C (320 F) - Operating pressure range from vacuum up to 10 bar (145 psig) - Pneumatic actuator Sistomat P designed for 10 bar (145psiG)operating pressure (EPDM-diaphragm) - Air supply pressure 5-6 bar (72,5-87 psig). Design Soft sealing valve, weir type, either manual or pneumatic actuator operated. Sealing in the seat and towards the outside by a diaphragm, no entrapment areas. Suitable for SIP and CIP. Self draining angle indicated by hash-marking on buttweld end. Actuator: SISTOMAT-P LAP-SF Air to open - Spring to close (DN 06-50) LAD-SF Air to open - Spring to close (DN 65-) Specification Valve -buttweld ends DIN Serie A ISO 4200 (DIN Serie B) OD ASME BPE (DIN Serie C) SMS 3008 JIS-G clamps DIN ASME BPE SMS 3017 JIS-G marking DIN/EN 19 (ISO 5209) ASME BPE 2002 Inspection Material certificate EN EN Final inspection EN According to American standards (ASME BPE-2002) The SISTO valves meet the safety requirements of the Pressure Equipment Directive 97/23/EG (PED) of annex I for fluids of the groups 1 and 2, Modul H. Materials DN size Body 316L(AISI) 316L(AISI) only forged design Investment casting Fe<2% (1.4435) (1.4435) Bonnet 316L(AISI) 316L(AISI) JL1040/JS1025RN Compressor 316L(AISI) 316L(AISI) JL-1040/JS-1025 Diaphragm EPDM(FDA) EPDM(FDA) EPDM(FDA) Screws 304(AISII) 304 (AISI) 304 (AISI) Handwheel PA6GF30 PA6GF30 Steel/PA coated Actuator PA6GF30 PA6GF30 Steel/PA coated Material options Body Body forged material 316L according to ASME BPE sulphur content<0,017%, BN2 FE<0,5% Diaphragm, 2pieces TFM/EPDM (FDA) CFR21 Section C Diaphragm, bonded TFM/EPDM (FDA) CFR21 Section C Design options Body design: T-form and tank-bottom-valves on others request Body end connection:clamps, flanges and others Accessories: Limit switches, adjustable travel stop and positioner Internal body finish Electropolished: Ra 35µin, Ra 25µin, Ra 20µin, Ra 11µin Ra 0,8µm, Ra 0,6µm, Ra 0,4µm, Ra 0,25µm Option: polished Further surface finish on request. DN size.5-2 DN 65- size On all inquiries / orders please specify 1 -Type 6 - Fluid 2 - DN 7 - Surface quality 3 - Working pressure 8 - Diaphragm quality 4 - Air supply pressure 9 - Actuator 5 - Operating temperature 10 - Certificate

2 * * / * SISTO DN SISTO DN SISTO DN 65- SISTO size 1/4-3/8 SISTO size 1/2-2 SISTO size 2.1/2-4 Item no. Designation Material Note body 316L (AISI) investment casting (1.4435) / forged bonnet 316L (AISI) investment casting (1.4409) bonnet JL-1040/PA grey, plastic coated steel stem 316L (AISI) stem 430F (AISI) 310 screwed bush brass ring EPDM 443* diaphragm EPDM FDA, CFR 21 Section bearing disc B 1112 (AISI) disc PTFE/graphite sliding disc.4104 on DN disc PTFE/A2 on DN compressor 316L investment casting (1.4409) compressor JL-1040 disc 304 (AISI) 562 locking pin 304 (AISI) upper opening indicator ABS/Luran upper opening indicator ABS/Luran 840 adaptor PA6GF hexagon screw 304 (AISI) DIN stud 304 (AISI) on DN 915 floating nut brass square nut B 1112 (AISI) hexagon nut 304 (AISI) hexagon nut 304 (AISI) 932 retaining ring spring steel DIN spiral spring support St2K BK on DN handwheel PA6GF30 30% glass fiber reinforced black handwheel St14/PA coated grey, plastic coated steel *recommended spare parts

3 * * * 412.1* * 443.1* * * * 901.1/ SISTO DN SISTO DN SISTO DN 65- SISTO size 1/4-3/8 SISTO size 1/2-2 SISTO size 2 1/2-4 Air supply pressure: 5-7 bar (72,5-101,5psiG) Air supply pressure: 5-7 bar (72,5-101,5psiG) Item no. Designation Material Note Air supply pressure: 4-6 bar (58-87psiG) body 316L (AISI) investment casting / forged lower cover St37/PA coated grey, plastic coated steel upper cover St37/PA coated grey, plastic coated steel 160 screw cap PA6GF30 30% glass fiber reinforced black bonnet 316L investment casting (1.4409) bonnet JS-1025/PA coated grey, plastic coated steel 176 bottom plate PA6GF30 30% glass fiber reinforced black 200 stem 430F (AISI) 202 thrust stem 430F (AISI) 209 piston rod 316L (AISI) 412.1* O-ring Viton O-ring Perbunan O-ring EPDM O-ring NBR 443.1* diaphragm EPDM FDA, CFR 21 Section * actuator diaphragm NBR guide bush 316L (AISI) guide bush brass 550 bearing disc 303(AISI) galvanised compressor 316L (AISI) investment casting (1.4409) compressor JS-1025 disc 304 (AISI) 562 locking pin 304 (AISI) DIN EN spring guide St37 galvanised 595* piston St/NBR 621 opening indicator 316L (AISI) 840 adaptor 430F (AISI) hexagon screw 305 (AISI) DIN screw 8.8A2E 902 stud 304 (AISI) on DN 911 air connection brass for PA-tube 8 x floating nut brass hexagon nut 304 (AISI) hexagon nut 304 (AISI) on DN 932 retaining ring spring steel DIN spring 302 (AISI spring spring steel 951 spiral spring support St2K BK on DN 65- *recommended spare parts

4 4 G L 2 * Actuator requires valve stroke dimension vertical clearence. Investment casted body with buttweld end Face-to-face DIN Serie A ISO 4200 OD ASME BPE SMS 3008 JIS-G 3447 Height Height DN NPS ML L1 ODxs ODxs ODxs ODxs ODxs H1 H2 d D1 6 1/4 72 8x1 ** 10,2x1,6 ** 6,35x0,89 ** 8 5/ x1 ** 13,5x1,6 ML / x1,5 9,53x0,89 ** 15 1/2 12,7x1, /8 17,2x1,6 15 1/2 ML x1,5 21,3x1,6 20 3/4 19,05x1,65 Actuator Valve stroke /4 ML ,9x1, / x1, ML x1,5 25,4x1,65 25x1,2 25,2x1, ,7x /4 ML ,4x / x1,5 33,7x1,2 ** 31,8x1,2 ** /2 ML x1,5 38,1x1,65 38x1,2 38,1x1, / ,3x x1,5 50,8x1,65 51x1,2 50,8x1,5 ML ,3x2 Investment casted body with clamp DIN32676 DIN Serie A OD ASME BPE SMS 3008 JIS-G 3447 Handwheel Faceto- face DN NPS ML Di Da L2 Di Da L2 Di Da L2 Di Da H1 H2 d D1 6 1/4 63,5 6 ** 25,2 * 63,5 4,57 ** 25,2 * 8 5/16 63,5 8 ** 25,2 * ML /8 63, ,2 * 63,5 7,75 ** 25,2 * 15 1/2 63,5 9,4 25,2 * 15 1/ ,2 * ML / ,75 25,2 * 20 3/ ML , ,1 50, ,6 50, , / , ,3 ** 50, ,4 ** 50,5 ML / , ,8 50, ,6 50, ,7 50,5 Height Height Handwheel Actuator Valve stroke ML , , , all dimensions in mm, unless otherwise noted * Clamp not according to DIN32676 ** self-draining on request Buttweld end length min. 20mm ISO clamp and additional executions on request

5 5 Forged body with buttweld end Face-to-face DIN Serie A ISO 4200 OD ASME BPE SMS 3008 JIS-G 3447 Heigth Heigth DN NPS ML L1 ODxs ODxs ODxs ODxs ODxs H1 H2 d D1 6 1/4 ML x1 10,2x1,6 6,35x0,89 Actuator Valve stroke 8 5/16 ML x1 13,5x1,6 10 3/8 ML x1,5 9,53x0, /2 ML ,7x1, /8 ML ,2x1,6 9,53x0, /2 ML x1,5 21,3x1,6 12,7x1, /4 ML x1,5 19,05x1, /8 ML x1,5 17,2x1,6 9,53x0, /2 ML x1,5 21,3x1,6 12,7x1, /4 ML ,05x1, /4 ML x1,5 26,9x1,6 19,05x1, /2 ML x1,5 21,3x1,6 12,7x1, /4 ML x1,5 26,9x1,6 19,05x1, ML x1,5 33,7x2 25,4x1,65 25x1,2 25,4x1, /4 ML x1,5 42,4x2 33,7x1,2 31,8x1, /4 ML x1,5 42,4x2 33,7x1,2 31,8x1, /2 ML x1,5 48,3x2 38,1x1,65 38x1,2 38,1x1, ML x1,5 60,3x2 50,8x1,65 51x1,2 50,8x1, /2 ML x2 76,1x2 63,5x1,65 63,5x1,6 63,5x /2 ML x2 76,1x2 63,5x1,65 63,5x1,6 63,5x ML x2 88,9x2,3 76,2x1,65 76,1x1,6 76,3x2 4 ML x2 114,3x2,3 101,6x2,11 101,6x2 101,6x Forged body with clamp DIN32676 DIN Serie A ISO 4200 OD ASME BPE SMS 3008 JIS-G 3447 Handwheel Face-toface Face-toface Face-toface Higth Higth Handwheeator Actu- Valve stroke DN NPS ML L2 Di Da L2 Di Da L2 Di Da L2 Di Da L2 Di Da H1 H2 d D1 6 1/4 ML32 63,5 6 25,2 * 63,5 7 25,2 * 63,5 4,57 25,2 * 8 5/16 ML32 63,5 8 25,2 * 63,5 10,3 25,2 * 10 3/8 ML32 63, ,2 * 63,5 7,75 25,2 * 15 1/2 ML32 63,5 9,4 25,2 * 10 3/8 ML ,2 * 89 7,75 25,2 * 15 1/2 ML ,2 * ,1 50,5 */** 89 9,4 25,2 * 20 3/4 ML ** ,75 25,2 * 10 3/8 ML ,2 * ,2 * 89 6,23 25,2 * 15 1/2 ML ,2 * ,1 50,5 * 89 9,4 25,2 * 20 3/4 ML ,75 25,2 * /4 ML ** ,7 50,5 */** ,75 25,2 * /2 ML ,2 * ,1 50,5 * 102 9,4 25,2 * 20 3/4 ML ,7 50,5 * ,75 25,2 * 25 1 ML , ,7 50, ,1 50, ,6 50, , ML , ,4 50, ,3 50, ,4 50, ML , ,4 50, ,3 50, ,4 50, ML , ,3 64 */** ,8 50, ,6 50, ,7 50, ML , ,3 77,5 */** , , , ML ** ,1 91 ** ,2 77,5 */** ,3 77,5 */** ,5 77,5 */** ML ** ,1 91 ** ,2 77,5 */** ,3 77,5 */** ,5 77,5 */** 80 3 ML ** ,3 106 ** ,9 91 ** ,9 91 */** ,3 91 */** ML ** ,7 130 */** , ** ,6 119 ** ,6 119 ** all dimensions in mm, unless otherwise noted * Clamp not according to DIN32676 ** Clamp welded Buttweld end length min. 20mm additional executions on request

6 SISTO Bestellschlüssel/How to order 6 Ventilkörper Body Configuration Ersatzteile Spare Parts Ventilkörper (SH) Body (SH) B00 SH ML000 W1 E A B C D E H I Membrane (SD) Diaphragm (SD) B SD 050 ML Oberteil (SB) Bonnet (SB) Werkstoff Material Nennweite DN1 Valve Size DN1 Membranlänge Diaphragm Length C D F Anschluß Valve End Connection B00 SB ML000 A1 A B C D G Membranwerkstoff Diaphragm Material Oberteil Type Of Bonnet Oberflächenqualität Surface Finish Nennweite DN2 Size DN2 B ML000 W1 48 A1 E A B C D E F G H I J Zubehör Accessories A B00 BB0 B01 B07 BB7 B08 BB8 B03 B06 B C Ventilkörper Body Configuration SISTO 2/2-Wege Ventilkörper SISTO 2/2way Valve Body SISTO 2/2-Wege Ventilkörper, Durchgangslöcher (nicht ML226) SISTO 2/2way Valve Body, through hole design (excl. ML226) SISTOT T-Ventilköprer SISTOT Zero Static T-Valve Body SISTOAS GMP/SAP-Ventilkombination 1 SISTOAS GMP/SAP-Valve Body 1 SISTOAS GMP/SAP-Ventilkombination 1, Durchgangslöcher SISTOAS GMP/SAP-Valve Body 1, through hole design SISTOAV GMP/SAP-Ventilkombination 1 SISTOAV GMP/SAP-Valve Body 1 SISTOAV GMP/SAP-Ventilkombination 1, Durchgangslöcher SISTOAV GMP/SAP-Valve Body 1, through hole design SISTOBAV Behälterventil SISTOBAV Tank Bottom Valve Body SISTOM Mehrsitzventil 1 SISTOM Multiport Block Valve Body 1 Gehäusewerkstoff Body material Gehäuse geschmiedet BN2 Body forged AISI 316L, ASME BPE-2002 Gehäuse Feinguss Body casting (316L) Gehäuse Sonderwerkstoff Body special material Nennweite DN1 Valve Size DN1 006 DN 006 1/4 008 DN 008 5/ DN 010 3/8 015 DN 015 1/2 020 DN 020 3/4 025 DN DN /4 040 DN /2 050 DN DN /2 080 DN DN 4 D Membranlänge Diaphragm Length E Anschluß Valve End Connection ML000 Standard Membranlänge (s. SISTO Katalog Nr. 8652) Standard Diaphragm Length (see SISTO Catalogue No. 8652) W0 DIN A Schweißende DIN A Butt Weld Ends optional: alternative Membranlänge optional: Special Diaphragm Length ML032 DN 06, 08, 10, 15 1/4, 5/16, 3/8, 1/2 ML046 DN 10, 15, 20 3/8, 1/2, 3/4 ML052 DN 10, 15, 20 3/8, 1/2, 3/4 ML058 DN 20 3/4 ML067 DN 15, 20, 25 1/2, 3/4, 1 ML082 DN /4 ML090 DN 32, /4, 1 1/2 ML108 DN 50 2 ML132 DN /2 ML158 DN 65, /2, 3 ML226 DN 4 C0 W1 C1 W2 C2 W3 C3 W5 C5 99 DIN A Clamp ISO 4200 (DIN 11866) Schweißende ISO 4200 (DIN 11866) Butt Weld Ends ISO 4200 (DIN 11866) Clamp SMS 3008 Schweißende SMS 3008 Butt Weld Ends SMS 3008 Clamp ASME BPE OD Schweißende (DIN C) ASME BPE OD Butt Weld Ends (DIN C) ASME BPE OD Clamp (DIN C) JIS-G 3447 Schweißende JIS-G 3447 Butt Weld Ends JIS-G 3447 Clamp Sonderanschluß Special Connection weitere Ausführungen auf Anfrage additional executions on request 1 SISTOAS/BAV und BM Ventilkörper, Ventilcode aus SISTO- Katalog wird zusätzlich benötigt. SISTOAS/BAV and BM Valve Body, Valve Code from SISTO- Catalogue is additionnally needed

7 SISTO Bestellschlüssel/How to order 7 F Membranwerkstoff Diaphragm Materials EPDM (FDA), bis 140 C EPDM (FDA), up to 284 F TFM/EPDM kaschiert (FDA), bis 140 C (nicht ML132, 158, 226) TFM/EPDM bonded (FDA), up to 284 F (excl. ML132, 158, 226) I Nennweite DN2 for T-, Mehrsitz und GMP/SAP Ventilkörper Size DN2 for T-, Multi port and GMP/SAP Valve bodies Siehe Buchstabe C Code see letter C 48 TFM/EPDM 2-teilig (FDA), bis 160 C (nicht ML032, 052) TFM/EPDM 2-pieces (FDA), up to 320 F (excl. ML032, 052) G Oberteil 2 Type Of Bonnet 2 M0 M3 M5 M6 M9 handbetätigt, PA6 Manually operated, PA6 handbetätigt Edelstahl (1.4404), autoclavierbar (bis ML108) Manually operated, Stainless steel, autoclavable (up to ML108) handbetätigt, PA6, Hubbegrenzung (Richtung offen) Manually operated, PA6, Stroke limiter (open) handbetätigt, PA6, Hubbegrenzung (Richtung geschlossen) Manually operated, PA6, Stroke limiter (close) handbetätigt, PA6, Verriegelung Manually operated, PA6, Locking mechanism J Zubehör Accesories ohne Zubehör without accessories Elektrische Stellungsanzeige S1, 125V (Position Open) Electrical Position Indicator S1, 125V (Position Open) Elektrische Stellungsanzeige SK49/50 Mikroschalter, 24V DC, 250V AC Electrical Position Indicator SK49/50 Microswitch, 24V DC, 250V AC Elektrische Stellungsanzeige SK49/50 Näherungsschalter 2-Leiter, 8V (Namur) Electrical Position Indicator SK49/50 Proximity Switches 2-Wire, 8V (Namur) Elektrische Stellungsanzeige SK49/50 Näherungsschalter 3-Wire, 10-30V Electrical Position Indicator SK49/50 Proximity Switches 3-Wire, 10-30V A1 pneumatisch, PA6, Feder schließend (SF) Pneumatically operated, PA6, Normally closed (SF) 00 ohne Magnetventil without Solenoid Valve A2 pneumatisch, PA6, Feder öffnend (OF) Pneumatically operated, PA6, Normally open (OF) 10 Magnetventil 3/2Wege, 24V DC Solenoid Valve 3/2Way, 24V DC A3 pneumatisch, PA6, Doppelt wirkend (AZ) Pneumatically operated, PA6, Double acting (AZ) 20 Magnetventil 3/2Wege, 24V AC, 50/60Hz Solenoid Valve 3/2Way, 24V AC, 50/60Hz A7 pneumatisch, Edelstahl (1.4404), Feder schließend (SF), (bis ML108) Pneumatically operated, Stainless Steel, Normally closed (SF), (up to ML108) 30 Magnetventil 3/2Wege, 110V AC, 50/60Hz Solenoid Valve 3/2Way, 110V AC, 50/60Hz L1 L2 L3 L7 pneumatisch, PA6, Feder schließend (SF), Hubbegrenzung (Richtung offen) Pneumatically operated, PA6, Normally closed (SF), Stroke limiter (open) pneumatisch, PA6, Feder öffnend (OF), Hubbegrenzung (Richtung offen) Pneumatically operated, PA6, Normally open (OF), Stroke limiter (open) pneumatisch, PA6, Doppelt wirkend (AZ), Hubbegrenzung (Richtung offen) Pneumatically operated, PA6, Double acting (AZ), Stroke limiter (open) pneumatisch, Edelstahl (1.4404), Feder schließend (SF), Hubbegrenzung (Richtung offen), (bis ML108) Pneumatically operated, Stainless Steel, Normally closed (SF), Stroke limiter (open) (up to ML108) Magnetventil 3/2Wege, 230V AC, 50/60Hz Solenoid Valve 3/2Way, 230V AC, 50/60Hz Magnetventil 3/2Wege, 24V DC, Stainless Steel Solenoid Valve 3/2Way, 24V DC, Stainless Steel Magnetventil 3/2Wege, 24V AC, 50/60Hz, Stainless Steel Solenoid Valve 3/2Way, 24V AC, 50/60Hz, Stainless Steel Magnetventil 3/2Wege, 110V AC, 50/60Hz, Stainless Steel Solenoid Valve 3/2Way, 110V AC, 50/60Hz, Stainless Steel Magnetventil 3/2Wege, 230V AC, 50/60Hz, Stainless Steel Solenoid Valve 3/2Way, 230V AC, 50/60Hz, Stainless Steel H P63 Oberflächenqualität (Durchschnitt) Surface Finish (Average) Ra 6,3µm Machined 250µ-in. ASME BPE Schlüssel ASME BPE Code Elektropneumatischer Stellungsregler 4-20mA Electropneumatic Positoner 4-20mA P32 Geschliffen Ra 3,2µm Mechanical 125µ-in Elektropneumatischer Stellungsregler, Kompaktausführung 4-20mA Electropneumatic Positoner compact 4-20mA P16 Geschliffen Ra 1,6µm Mechanical 60µ-in. - P25 Geschliffen Ra 0,8µm Mechanical 25µ-in. SFV3 P20 Geschliffen Ra 0,6µm Mechanical 20µ-in. SFV2 P15 Geschliffen Ra 0,4µm Mechanical 15µ-in. SFV1 E25 Elektropoliert Ra 0,8µm Electro-polished 25µ-in. - E20 Elektropoliert Ra 0,6µm Electro-polished 20µ-in. SFV6 E15 Elektropoliert Ra 0,4µm Electro-polished 15µ-in. SFV5 E10 Elektropoliert Ra 0,25µm Electro-polished 10µ-in. SFV4

8 8 SISTO DN 006- SISTO - B size 1/4-4 Compact and integrated design of actuator ensures installation under extreme room conditions Optional assembly of limit switches, adjustable travel stop and positioner Pneumatic actuator made of reinforced polyamid Actuator piston with vulcanized metal ring ensures smooth and friction reduced movements Investment casted found body, Fe<2%, with high dimensional accuracy, excellent surface finish and optimal cost Forged stainless steel body according to ASME BPE- 2002, sulphur content<0,017% and BN2 Fe<0,5%, ensures highest surface finish for sterile process and offers many variants of pipe connections Air connection shown in 90 Rotation Diaphragm ensures - dimensions according to industriel standard - absolute tightness - conformity to FDA No entrapment areas, only diaphragm and body are in contact with the medium This document is not contractual and may be amended without notice. Examples see catalogue 8652 SISTO sterile processes Manufacturing Company: SISTO Armaturen S.A. Zone Industrielle 6468 Echternach (Luxembourg) Phone: (+352) Fax (+352) sisto@ksb.com Rep office in USA: AMRI, Inc Silber Road Houston, Texas P.O.Box Houston, Texas ( USA) Phone: (+1) Fax: A KSB company /13-10 /