Abstract for the Electrospin Plenary lectures

Size: px
Start display at page:

Download "Abstract for the Electrospin Plenary lectures"

Transcription

1

2 1. Plenary lectures 1

3 Academician Seeram Ramakrishna National University of Singapore Abstract: Nanotechnology and Smart Wearables Nanomaterials, smart manufacturing, and circular economy vision are symbiotically related to the materials innovations. Together they enable better living clean air, water and energy, health and wellbeing, smart living and transportation, safety and security, and sustainability. Electrospinning has been developed as a viable manufacturing method for producing a range of nanofibers and nanoparticles of polymers, metals, ceramics, carbon, and their hybrids for high performance and demanding applications. It has also evolved into a 3D printing method, and preparation of new types of feedstock for 3D Printing. Innovative ideas on edible films, fabrics and devices are also emerging. Functional nanomaterials by electrospinning enable advances in air filtration, water purification, clean energy generation and storage, controlled drug delivery, tissue engineering, regenerative medicine, food packaging, high performance apparel, electronic-skin, wearables, and light-weight, damage tolerant materials for transportation, electricity transmission, buildings and construction. They also enable self-cleaning, super-hydrophilic, super-hydrophobic, and anti-microbial surfaces. This lecture provides an overview, and discusses emerging opportunities. Biography: Academician Professor Seeram Ramakrishna, FREng is the Director of Center for Nanofibers and Nanotechnology at the National University of Singapore (NUS), which is ranked among the top 25 universities in the world. He co-authored over 1,000 SCI indexed international journal papers and seven authored books which received ~88,000 citations and ~ 140 H-index. He is regarded as the modern father of electrospinning and nanofibers. He is a Highly Cited Researcher in the world (Clarivate Analytics). Thomson Reuters recognized among the World s Most Influential Scientific Minds. A European study placed him among the only 800 researchers with H index over 135 in the history of science and technology ( He received PhD from the University of Cambridge, UK; and The General Management Training from the Harvard University, USA. He is a Distinguished Alumni of IITM, India. He is an elected Fellow of UK Royal Academy of Engineering (FREng); Singapore Academy of Engineering; Indian National Academy of Engineering; and ASEAN Academy of Engineering & Technology. He is an elected Fellow of International Union of Societies of Biomaterials Science and Engineering (FBSE); Institution of Engineers Singapore; ISTE, India; Institution of Mechanical Engineers and Institute of Materials, Minerals & Mining, UK; and American Association of the Advancement of Science; ASM International; American Society for Mechanical Engineers; American Institute for Medical & Biological Engineering, USA. He received numerous recognitions w h i c h i n c l u d e Ch i n a Changjiang (Yangtze River) Scholar and 1000 talents distinguished professor; Cambridge Nehru Fellowship of India, and LKY Fellowship of Singapore; C UT Ho n o r a r y E n g i n e e r i n g D o c t o r a t e ; APA Distinguished Researcher Award, IFEES President award- Global Visionary; GEDC Ambassador; ASEAN Outstanding Engineer Award; IES Prestigious Engineering Achievement Award; IITM Distinguished Alumni Award; NUS Outstanding Researcher Award; CPS Biomaterials Award. He chairs the Circular Economy taskforce at NUS, and a member of Enterprise Singapore s National Mirror Committee for ISO/TC323 on Circular Economy. He is the Editor-in-Chief of Springer NATURE journal Materials Circular Economy. He is an editorial board member of Springer NATURE journal Advanced Fiber Materials; Elsevier Journal Current Opinion in Biomedical Engineering; and NATURE Scientific Reports. 2

4 Andreas GREINER Functional sponges from short electrospun fibers University of Bayreuth Macromolecular Chemistry, Universitätsstrasse 30, Bayreuth, Germany Abstract: Sponges are open-cellular materials while foams are defined as closed cellular material. Spongy materials have received considerable interest in materials science for various applications. Ultralight sponges (density < 10mg/cm3) offer unique advantages such as low weight and large pore-volume. We found that dispersed short electrospun fibers could selfassemble to ultralight polymer sponges which show decent compressibility and potential for application in tissue engineering. The mechanical properties of the sponges were improved considerably by chemical vapor deposition of poly(p-xylylene) (PPX) without significant increase in density. These sponges showed very good heat insulation and also superhydrophobic properties which makes them of particular interest for textile application and oil/water separation. The concept of sponge property enhancement by post-processing coating was extended to liquid coating which was shown recently for polyimide sponges. The sponges showed very good compressibility, very high thermal stability even on air, very low volume shrinkage, and very good heat insulation. The sponge showed also exceptional performance as carrier for nanoparticle catalysts. These spongy catalysts were reusable many times and showed the highest reaction rates as comparted to other heterogeneous systems. The polymer sponges could take up a lot of guest material due to their large pore volume. Consequently, the ultralight sponges could take liquids up to 700 times of their own weight. In this state sponges behave rheologically like a gel and in fact show the characteristics of an organogel. Since organogels are prepared by different route we have defined the gels made by filling of the pores of the sponges as spongy gels. The sponges could also take up a large amount of drug and display retarded drug release as shown recently for the anti-malaria drug artemisone. Recently, we could show, that superhydrophobic hollow sponges based on electrospun fibers could be utilized as reaction containers for the highly efficient absorption of CO 2 and biomineralisation of CaCO 3. Biography: Andreas GREINER received his Ph D. degree in Chemistry from the University of Marburg in 1988 and joined did his postdoc in 1989 at the University of California, Santa Barbara, USA. He was appointed associate professor for organic chemistry and macromolecular chemistry at the University of Mainz in In 2000 he became full professor for polymer chemistry and technology at the University of Marburg and joined in 2012 University of Bayreuth as distinguished professor for macromolecular chemistry. Since 2013 he is heading the business unit Future Solution of New Materials Bayreuth GmbH. Present research topics are functional biobased polycarbonates, electrospinning of polymer mesofibers, polymerfunctionalized nanoparticles, poly(p-xylylene)s by CVD, polymers for coatings, filtration, textiles, medicine, pharmacy, agriculture, and as electrodes for microbial fuel cells. Greiner has authored more than 350 scientific publications and was ranked no. 36 in Thomson Reuters s top 100 materials science citation ranking list out of materials scientist for the decade Greiner is teaching at the Zhejiang University and is guest professor at Donghua University and Nanchang Normal University. 3

5 Electrospun 3D Nanofibers Scaffolds for Tissue Engineering Xiumei MO College of Chemistry Chemical Engineering & Biotechnology, Donghua University, Shanghai , China Abstract: Electrospinning fabrication technique most commonly produces relatively 2D mats and the construction 3D structure nanofibers with higher porosity is still a major challenge. In this study, two methods were used to fabricate the 3D nanofiber scaffolds. A dynamic electrospinning method were developed to fabricate the nanoyarn scaffold, by this way electrospun poly(l-lactide-co-εcaprolactone)/collagen (P(LLA-CL)/Col) nanofibers were deposited and twisted into yarns in a water vortex before collecting on a rotating mandrel to form a nanoyarn scaffold. The nanoyarn scaffold contained 3D aligned microstructures with larger interconnected pores and higher porosity comparing with nanofiber scaffold. The nanoyarn scaffold have been successfully used for tendon tissue regeneration of rabbit and blood vessel tissue regeneration in rat. Gelatin/PLA nanofiberous scaffold was fabricated by using combined electrospinning and freeze-drying. Gelatin/PLA nanofibers membranes were prepared by electrospinning; secondly, nanofibers membranes were cut into small pieces and were dispersed in tert-butanol by homogenizer; thirdly, the dispersions were frozen and freeze dried. Finally the scaffold was crosslinked by heating at 190 O C or grafting HA on the nanofibers surface of scaffold by EDC/NHS. Thus obtained 3D nanofiber scaffold could promote cells growth and proliferation. In order to evaluate the repair capacity of 3D scaffold in vivo, an articular cartilage defect was created on rabbits and scaffolds were implanted into the defect. The in vivo study indicated that the cartilage repair capacity of scaffold without HA was limited, but scaffold modified with HA could enhance the repair of cartilage..biography: Dr. Xiumei MO is a professor of Biomaterials in Donghua University. She once had two years Postdoc experience in Kyoto C University, three years research D fellow experience in National University of Singapore, one year visiting professor experience in Aachen University of Applied Science and Technology. In Donghua University she was granted 28 projects related with nanofiber fabrication for different tissue regeneration and hydrogel as tissue adhesive. She has published more than 300 papers. ISI Web of Science showed that she ranking No.7 in the world on electrospun nanofiber publication. She got the Science Technical Invention Awards from Shanghai Municipality in 2008,Science and Technology Progress Awards from State Department of People s Republic of China in 2009, Nature Science Awards from Shanghai Government in She is the committee members of China Biomaterials Society as well as Biomedical Engineering Society Biomaterials Branch. : 1. Binbin Sun, Zifei Zhou, Tong Wu, Weiming Chen, Dawei Li, Hao Zheng, Hany El- Hamshary, Salem S. Al-Deyab4, Xiumei Mo*, Yinxian Yu*, Development of Nanofiber Sponges-Containing Nerve Guidance Conduit for Peripheral Nerve Regeneration in Vivo, ACS Applied Materials & Interfaces, 2017, 9, Jun Fang, Jialing Zhang, Jun Du, Yanjun Pan, Jing Shi, Yongxuan Peng, Weiming Chen, Liu Yuan, Sang-Ho Ye, William R. Wagner, Meng Yin,* and Xiumei Mo*, Orthogonally Functionalizable Polyurethane with Subsequent Modification with Heparin and Endothelium-Inducing Peptide Aiming for Vascular Reconstruction,ACS Applied Materials &Interfaces, 2016, 8, Weiming Chen, Shuai Chen, Yosry Morsi, Hany El-Hamshary, Mohamed El-Newhy, Cunyi Fan,* and Xiumei Mo*, Superabsorbent 3D Scaffold Based on Electrospun Nanofibers for Cartilage Tissue Engineering, ACS Applied Materials &Interfaces, 2016, 8,

6 Tong Lin Some Novel Understandings about Electrospinning Deakin University Waurn Ponds Campus, Geelong, Victoria 3216, Australia Abstract: Electrospinning is a simple but efficient method to prepare polymeric nanofibers and electrospun nanofibers have shown broad applications in diverse fields, ranging from biomedical, healthcare, and chemical engineering to electronics, environment protection, energy and functional textiles. This talk will introduce our research activity focused on slot electrospinning and piezoelectric nanofibers. We have found that curved slots could effectively mitigate unevenness of electric field along the spinneret and aerodynamic forces added to a slot considerably improve electrospinning behaviors. Polyacrylonitrile after being electrospun into a fibrous membrane shows unusually strong piezoelectricity. Biography: Professor Tong Lin received his PhD degree in physical chemistry from Chinese Academy of Sciences (CAS) in He has served as Professor and Personal Chair at Deakin University since Prof Lin has been an active researcher in the field of electrospinning, functional fibers and polymers. He contributes to the development of needleless electrospinning for large-scale nanofiber production and finding novel applications of nanofibrous materials. Prof Lin has authored or co-authored over 240 peer-reviewed journal articles, 31 books/book chapters, and 80 other papers. Based on the Google Scholar database, the total citation of his publications is over 11000, with an h-index over 55. Prof Lin has also been awarded the Australian Research Council (ARC) Future Fellow and Fellow of the Royal Society of Chemistry (RSC, UK). 5

7 Bin DING Electrospun Nanofibrous Materials: Assembly of Fibers from Onedimensional to Three-dimensional Innovation Center for Textile Science and Technology, Donghua University, Shanghai , China Abstract: Benefiting from the compelling features of fine diameter, extremely high aspect ratio and easy fabrication of widely available materials, nanofibrous materials hold great promising prospects in a variety of application fields, such as environment, energy, biology, etc. Generally, electrospinning is one of the most versatile and effective techniques to manufacture the nanofibrous materials with multi-dimensional and various morphological structures. To be specifically, one-dimensional (1D) nanofibers can be produced through the assembly of solute during the uniaxial stretching in the presence of solution jet when they are charged under an electrical field. Two-dimensional (2D) nanofibrous membranes can be constructed at the macroscopic level from the 1D nanofibers, which are previously deposited on a collector in the manner of being randomly distributed and stacked with each other. With an increase of membrane thickness or introducing an auxiliary molding approach, threedimensional (3D) bulk nanofibrous materials can be further fabricated. However, comprehensively considering the industrialization process of functional nanofibrous materials, the electrospun nanofibers are still subjected to some unfavorable bottlenecks which have largely limited their applications in certain areas. For instance, (1) the brittleness of 1D ceramic nanofibers have severely restricted their practical applications in thermal insulation; (2) the large diameter of nanofibers and the unsatisfactory tortuous structure of 2D nanofibrous membranes have significantly limited their function in selective separation; (3) the anisotropic lamellar deposition character of electrospun nanofibers enables the poor mechanical strength with no elastic resilience of current 3D nanofibrous materials, consequently making them hard to be applied in sound absorption, warmth retention, etc. To fully address the above mentioned challenges, we have conducted a systematical study towards the controllable fabrication, structure-function relationships as well as the mass production technology. We have developed the novel routines to successfully fabricate the flexible ceramic nanofibers, 2D nanonets and nanofibrous aerogels, respectively. Furthermore, the practical application performance of electrospun nanofibrous materials in the fields of thermal insulation, sound absorption, selective separation and warmth retention have been thus greatly enhanced. Such progress might open up the possibility of sustainable lives in an alternative way for human beings in the near future. Biography: Bin Ding received his PhD degree from Keio University in Japan in After two years of post-doctoral in Keio University ( ) and a year of post-doctoral in the University of California at Davis ( ). He stated his career as a professor of materials science in Donghua University in Now, he is the vice director of Innovation Center for Textile Science and Technology at Donghua University. His research interests include the controllable fabrication and multifunctionalizations of micro/nanofibrous materials. He has authored 239 papers published on journals such as Nat. Commun., Sci. Adv., Adv. Mater., etc. His entire publications have been cited for over 9000 times, and his H-index is 61. The honours that he has received including the Distinguished Achievement Award of The Fiber Society (USA) in 2014, Cheung Kong Scholar in 2017 and the Scientific and Technological Innovation Leading Talents of National People Plan in 2018, etc. 6

8 2. Invited 2.1 Nanofiber for medical and biology 7

9 ELECTROSPINNING IN MEDICAL DEVICE DEVELOPMENT Deon Bezuidenhout 1,2 1 Biomaterials Group, Cardiovascular Research Unit, Faculty of Health Sciences, University of Cape Town, South Africa. 2 Strait Access Technologies. 313 Chris Barnard Building, Anzio Road, Observatory, Cape Town, South Africa. Electrospun materials are widely advocated for use in medical devices as they (i) are readily produced from a large range of materials in a variety of geometries (ii) can be tailored in mechanical properties, (iii) resemble the extracellular matrix (ECM) and (iv) lend themselves to the incorporation of drugs, proteins and genetic material to manipulate the host response. The combination and roles of various of these properties are exemplified by three cardiovascular applications: (a) small diameter vascular grafts for in vivo regeneration of peripheral vessels, (b) transcatheter prostheses for the minimally invasive replacement of heart valves, and (c) endovascular grafts for treatment of aortic aneurysms. After establishment of proof of concept using foamed grafts of high porosity [1], electrospun scaffolds with increased porosity were manufactured by sacrificial fibre/porogen incorporation/extraction. (a) Heparin and dexamethasone were incorporated into electrospun scaffolds for antithrombogenicity/ improvement of vascularization and control over inflammatory response, respectively, and small diameter grafts were subsequently produced for in vivo evaluation. (b) Electrospinning was used to develop unique skirts for transcatheter heart valves for the prevention of paravalvular leakage (Figure 1), and for leaflets suitable for tissue engineered heart valves [2]. (c) Finally, proof of concept of the use of electrospinning as a tool in the production of endovascular grafts is also described. These examples demonstrate the utility of electrospinning as a powerful tool not only in the development of cardiovascular devices, and by extension also for many other medical applications where porous, membranous scaffolds or structures are required. Key Words: Electrospinning, cardiovascular devices, vascular grafts, heart valves, tissue regeneration. Acknowledgements: The author acknowledges and thanks all the staff and students at the Cardiovascular Research Unit and at Strait Access Technologies Pty Ltd who contributed to this work. [1] Pennel T*, Bezuidenhout D*, Koehne J, Davies NH, Zilla. Transmural capillary ingrowth is essential for confluent mid-graft healing. Acta Biomaterialia, 2018, 65, [2] Scherman J, Bezuidenhout D, Ofoegbu C, Williams DF, Zilla P. TAVI for low to middle income countries. Eur Heart Journal, 2017, 38(16): (a) (b) (c) Figure 1. Polymeric transcatheter heart valve with electrospun skirt (a). Micrographs of (b) standard and (c) covalently heparinized skirt material. 8

10 Electrospun Hydrogel Fibrous Scaffolds for Rapid in vivo Vascularized Skin Flap Regeneration Wenguo Cui* Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai , P. R. China. Electrospinning technology has a wide range of applications in creating extracellular matrix (ECM)-mimicking ultrafine fibrous membranes with fiber diameters ranging from nanometers to micrometers. Many studies reported that 2D- or 3D-structures of electrospinning fibers meshes were fabricated using poly (L-lactic acid) (PLLA) or poly (ε-caprolactone) (PCL) for vascularization. But in vitro results indicated that endothelial cells can only grow on the surface of the fiber mesh due to the small pore size, making it difficult to construct 3D vasculature in the scaffolds. In addition, stiffness material is not suitable for the soft tissue regeneration, which would cause severe inflammatory response in vivo.[9]distal necrosis of random skin flap is always clinical problematic in plastic surgery. The development of three-dimensional (3D) functional vascular networks is fundamental for the survival of a local random skin flap. Herein, we demonstrated an effective technique on constructing 3D fibrous scaffolds for accelerated vascularization using a photocrosslinkable natural hydrogel based on gelatin methacryloyl (GelMA) by electrospinning. We found that the ultraviolet (UV) photocrosslinkable gelatin electrospun hydrogel fibrous membranes exhibit soft adjustable mechanical properties and controllable degradation properties. Furthermore, we observed that the optimized hydrogel scaffolds could support endothelial cells and dermal fibroblasts adhesion, proliferation and migration into the scaffolds, which facilitated vascularization. Importantly, a rapid formation of tubes was observed after 3 days seeding of endothelial cells. After GelMA fibrous scaffold implantation below the skin flap in a rat model, it was found that the flap survival rate was higher than the control group, and there were more microvasculars formation, which was potentially beneficial for the flap tissue vascularization. These data suggest that GelMA hydrogels can be used for biomedical applications that require the formation of microvascular networks, including the development of complex engineered tissues. Key Words: Hydrogel, Liposomes, Control Release, Bone Regeneration, Mechanical Enhancement Acknowledgements: This work was supported by the Shanghai Municipal Education Commission Gaofeng Clinical Medicine Grant Support ( ). [1] Zhao X, WG*, et al. Cell infiltrative hydrogel fibrous scaffolds for accelerated wound healing. Acta Biomater. 2017;49: [2] Sun X, WG*, et al. Electrospun photocrosslinkable hydrogel fibrous scaffolds for rapid in vivo vascularized skin flap regeneration. Adv Func Mater. 2017;27: [3] Chen C, WG*, et al. Bioinspired Hydrogel Electrospun Fibers for Spinal Cord Regeneration. Adv Func Mater. 2019;9:

11 Reconstruction of abdominal wall utilizing electrospun poly (L-lactide-cocaprolactone) blended with a porcine fibrinogen scaffold: an experimental study in the canine Hongbing He Zhongshan Hospital affiliated to Fudan University, Shanghai, China Abstract The use of permanent synthetic materials for abdominal wall repair is currently the method of choice. However, they are not ideal as short- and long-term complications with these materials have been reported due to, amongst other issues, chronic groin pain (pain lasting longer than 3 months) which occurs in 10 12% of patients and host immunological responses to foreign body grafts. In the present randomized paired study we compared an electrospun composite scaffold composed of poly-l-lactide-co-caprolactone[ P-(LLA-CL)] blended with porcine fibrinogen (F-Fg)[P-(LLA-CL)-F-Fg] with a polypropylene mesh (PPM) as a control in a canine abdominal wall defect model (with 36 Beagle dogs). A blend ratio of 4:1 P-(LLA- CL):F-Fg1 scaffold possessed optimal physical characteristics including shrinkage rate, mechanical strength, porosity and super-hydrophilic property. Macroscopic, histological, and biomechanical evaluations were performed over a period of 36 weeks and the results indicated that the resorbable P-(LLA-CL)/F-Fg1 electrospinning scaffold could effectively induce and augement abdominal skeletal muscle regeneration. The degradation rate of the P-(LLA- CL)/F-Fg1 scaffold and the rate of new tissue in-growth reached a balance and the biomechanical strength returned to the baseline within 2 weeks of implantation. The immunohistological data demonstrated the presence of regenerated skeletal muscle tissue for P-(LLA-CL)/F-Fg1 scaffolds, whereas the PPM exhibited dense fibrous encapsulation along the perimeter of the meshes. The data presented in our study provides the foundation for future clinical applications of P-(LLA-CL)/F-Fg1 composite scaffolds for the reconstructive surgery of abdominal wall defects. Keywords: Poly (L-lactide-co-caprolactone); Fibrinogen; Scaffold; Abdominal Wall Repair; Regeneration; : [1] Grounds MD. The need to more precisely define aspects of skeletal muscle regeneration. Int J Biochem Cell Biol 2014;56: [2] Plencner M, East B, Tonar Z, Otahal M, Prosecka E, Rampichova M, et al. Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-epsilon-caprolactone nanofibers and growth factors for prevention of incisional hernia formation. Int J Nanomedicine 2014;9: [3] Hu MS, Maan ZN, Wu JC, Rennert RC, Hong WX, Lai TS, et al. Tissue engineering and regenerative repair in wound healing. Ann Biomed Eng 2014;42:

12 DNA aptamer-functionalized magnetic short nanofibers for efficient capture and release of circulating tumor cells Yunchao Xiao, Xiangyang Shi* State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai , P. R. China. Isolation and analysis of circulating tumor cells (CTCs) is of great significance for early diagnosis and individualized treatment of cancer. Currently, CTCs isolated by conventional magnetic separation method are tightly coated with magnetic materials, which is not conducive to the subsequent detection and analysis. Herein, we report a facile approach to fabricate DNA aptamer-functionalized magnetic short nanofibers for efficient capture and release of CTCs. Firstly, polyethyleneimine (PEI)-stabilized Fe 3 O 4 nanoparticles (Fe 3 O were obtained by one-step hydrothermal method, and then Fe 3 O alcohol (PVA) nanofibrous mat was prepared via electrospinning. Afterwards, Fe 3 O mat was subjected to a homogenizing process to form Fe 3 O magnetic short nanofibers, followed by surface modification with DNA aptamer. We show that the prepared Fe 3 O magnetic nanofibers have an average length of 9.6 μm and diameter of nm with a saturated magnetization of 12.3 emug -1. After modified with DNA aptamers, Fe 3 O fibers were able to specifically capture MCF-7 cells with a capture efficiency of 87%, and the captured cells can be rapidly and non-destructively released by the introduction of endonuclease with a release efficiency of more than 90% within 20 min (Figure 1). In conclusion, DNA aptamer-functionalized magnetic short nanofibers in this study can be used for efficient capture and effective release of tumor cells, which have comparable capture efficiencies to commercial magnetic beads and significantly higher release efficiencies than commercial magnetic beads, thus holding a great potential for cell sorting applications. Figure 1. (a) Capture efficiency of MCF-7 cells after incubation with magnetic short nanofibers and magnetic beads for different time periods. (b) Release efficiency of MCF-7 cells after treated with Benzonase Nuclease (25 U/mL) for different time intervals at 37 o C. (c) SEM images of MCF-7 cells after capture and after release. Key Words: short nanofibers, magnetic separation, circulating tumor cells, DNA aptamer Acknowledgements: This study was financially supported by National Natural Science Foundation of China ( and ), the Science and Technology Commission of Shanghai Municipality ( ), and Fundamental Research Funds for the Central Universities (for Y Xiao and X Shi). 11

13 Electrospinning for regenerative medicine; challenges and solutions to bring products to the market Marc Simonet IME Medical Electrospinning, Van Dijklaan 6, 5581WG Waalre, The Netherlands. In the regenerative medicine field, electrospinning has gained widespread interest to produce scaffolds that mimic the extracellular matrix (ECM) for tissue engineering. This technique often was and still is the preferred choice due to its capability to produce 3-dimensional fibrous ECM lookalike scaffolds with similar nano- to micrometer length scales using an extensive range of natural and synthetic polymers. 1 The process is highly versatile and tunable, allowing to tailor scaffold properties to fit many demands and various Medical applications. 2 This versatility has led to more than scientific publications and nearly 2000 patents on electrospinnning for biomedical engineering. However, up until now only handful medical products have reached the clinic. Controlling all the electrospinning parameters, which create the base of this method s versatility, has proven to be a major challenge. 3 As a consequence, the translation of research into the development of products that truly reach patients has been severely hampered. We will show that thanks to a better understanding and tighter control on process parameters, and tackle challenges such as a general lack of reproducibility and a limited heterogeneous cell ingrowth, the number of electrospun Medical products is expected to grow significantly and electrospinning can finally fulfill its great potential for tissue engineering and the regenerative medicine market. Key Words: Electrospinning, scaffolds, regenerative medicine, medical device : [1] Sell S, Barnes C, Smith M, et al. Extracellular matrix regenerated: tissue engineering via electrospun biomimetic nanofibers [J]. Polymer International, 2007, 56(11): [2] Simonet M, Stingelin N, Wismans J, et al. Tailoring the void space and mechanical properties in electrospun scaffolds towards physiological ranges [J]. Journal of Materials Chemistry B., 2014, 2(3): [3] Putti M, Simonet M, Solberg R, et al. Electrospinning poly(ε-caprolactone) under controlled environmental conditions: Influence on fiber morphology and orientation [J]. Polymer, 2015, 63:

14 Single-step approach for controlled surface properties of electrospun fibers via alternating voltage polarities Urszula Stachewicz 1 1 International Centre of Electron Microscopy for Materials Science, Faculty of Metals Engineering and Industrial Computer Science, AGH University of Science and Technology, Al. Mickiewicza 30, Krakow, Poland, The porosity of electrospun mat and scaffolds reaches often more than 90 %, [1] which gives an enormous advantage in skin or would care dressing. Apart porosity and meshes geometry the key parameters in these biomedical applications are surface properties, which we control via single step electrospinning process by alternating voltage polarities in electrsopinning. [2] Voltage polarity defines the charge accumulated on the surface of the liquid jet and the surface of the fibers. Positive polarity attracts negatively charged groups to fibers surface, whereas negative polarity moves the negatively charged functional groups away from the surface, while the polymer solution is in the liquid form. This way we can control the surface chemistry, [3] wettability [2] and additionally surface potential of electrospun polymer fibers. [4, 5] Within our research we characterized so far surface chemistry of PCL and PVDF fibers using x-ray photoelectron microscopy (XPS) and surface potential with Kelvin probe force microscopy (KPFM). We proved the significant effect of surface potential on cell integration with the fibers meshes and cells development for the regeneration processes [5] increasing their responses in medical treatments. Acknowledgments: The study was conducted within Nanofiber-based sponges for atopic skin treatment project, which is carried out within the First TEAM programme of the Foundation for Polish Science co-financed by the European Union under the European Regional Development Fund, project no POIR / Key Words: fibers, surface potential, cells, tissue engineering, voltage polarity [1] Stachewicz, U., Szewczyk, P., Kruk, A., Barber, A.H., Czyrska-Filemonowicz A., Pore shape and size dependence on cells growth into electrospun fiber scaffolds for tissue engineering: 2D and 3D analyses using SEM and FIB-SEM tomography, Materials Science and Engineering- C Materials for Biological applications, 95, , 2019 [2] Stachewicz, U., Stone, C.,Willis, C. R. and Barber, A.H., Charge assisted tailoring of chemical functionality at electrospun nanofiber surfaces, Journal of Materials Chemistry, 22, 22935, 2012 [3] Busolo, T., Ura, D. P, Kim, s., Marzec, M. M., Bernasik, A., Stachewicz, U., Kar-Narayan, S., Surface potential tailoring of PMMA fibres by electrospinning for enhanced triboelectric performance, Nano Energy, 57, , 2019 [4] Metwally, S., Karbowniczek, J.E., Szewczyk, P.K., Marzec, M.M., Gruszczyński, A., Bernasik, A., Stachewicz, U., Single-step approach to tailor surface chemistry and potential on electrospun PCL fibers for tissue engineering application, Advanced Materials and Interfaces, , 2019 [5] Szewczyk, P.K, Metwally, S., Karbowniczek, J., Marzec, M., Stodolak-Zych, E., Gruszczyński,A., Bernasik, A., Stachewicz, U. Surface potential controlled cells proliferation and collagen mineralization on electrospun PVDF fibers scaffolds for bone regeneration, ACS Biomaterials Science & Engineering, 5 (2), pp ,

15 Electrospinning of biomolecules and cell-derived bodies Ukrit Angkawinitwong, Rita Trindade and Gareth R. Williams UCL School of Pharmacy, University College London, Brunswick Square, London, WC1N 1AX, UK. Increasingly, the most potent emerging medicines are based not on small-molecule active ingredients but instead on large biomolecules such as peptides and proteins, or even on cells and sub-cellular components. These offer a number of benefits in terms of efficacy and specificity, but are difficult to process using traditional pharmaceutical processing approaches because their three-dimension tertiary structure (crucial for biological activity) is easily degraded, for instance by the application of heat in spray drying. Since electrospinning avoids the use of heat, it offers a potential route to develop stable and potent medicines from these hard-to-handle active ingredients. This presentation will describe recent results in the production of electrospun formulations of the protein drug bevacizumab (widely used for the treatment of cancer and blinding conditions in the eye) and extracellular vesicles (cell-secreted bodies which can recapitulate the effects of stem cells in tissue regeneration, but with reduced side effects). These active ingredients were processed into fibers, fully characterized, and then their functional performance assessed in vitro. Through careful control of the processing parameters, we are able to produce bevacizumab formulations which provide zero-order release of the protein over at least 60 days, with no degradation or loss of potency (Fig. 1) [1]. We further show that extracellular vesicles can be processed by electrospinning with no loss of efficacy [2]. The new formulations prepared in this work offer a number of benefits in terms of obviating some of the risks (e.g. tumorigenicity, immunogenicity) of using stem cells in tissue regeneration, and could lead to implantable drug delivery systems able to provide sustained treatment of a number of severe conditions with minimal intervention by medical professionals. Fig 1: Bevacizumab-loaded electrospun fibers (left) can provide zero-order release of the drug over 60 days (right). Key Words: Electrospun fibers, protein, extracellular vesicle, bevacizumab, tissue regeneration. Acknowledgements: We thank the EPSRC for funding Rita Trindade s PhD under the EPSRC Centre for Doctoral Training in Advanced Therapeutics and Nanomedicines (EP/L01646X/1) : [1] Angkawinitwong U, Awwad SA, Khaw PT, Brocchini S, Williams GR. Electrospun formulations of bevacizumab for sustained release in the eye. Acta Biomater., : [2] Trindade R, Renault N, Menasche P, Williams GR. Extracellular vesicles can be processed by electrospinning with no loss of efficacy. Chem. Commun., 2019, submitted. 14

16 New Forms of Electrospun Nanofiber Materials for Biomedical Applications Jingwei Xie, Shixuan Chen, Yajuan Su, Vitharikunnil John Johnson, and Hongjun Wang Department of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, United States Introduction. Electrospinning has provided an enabling technology platform for fabricating novel structured materials in a rich variety of biomedical applications including drug delivery, sensing, tissue engineering, and regenerative medicine. In this presentation, we will show several examples of new forms of electrospun nanofiber materials and their potential applications in biomedical fields. 1-3 Research Design. In combination with innovative gas-foaming, cryocutting/homogenization, electrospraying, and/or freeze drying, we were able to fabricate new forms of electrospun nanofiber materials including expanded nanofiber sponges, hybrid nanofiber aerogels, and nanofiber microspheres. 1-3 We have explored the application of these new forms of electrospun nanofiber materials in local drug delivery, wound healing, bone regeneration, hemostasis, and cell delivery. Results and Discussion. We have developed a controllable method for expanding electrospun nanofiber mats in the third dimension while preserving imparted anisotropic features and cues 1. The obtained 3D expanded scaffolds support robust cellular infiltration and proliferation throughout bulk of the materials. In addition, 3D hybrid nanofiber aerogels composed of electrospun PLGA-collagengelatin and Sr-Cu codoped bioactive glass fibers with incorporation of heptaglutamate E7 domain specific BMP-2 peptides were developed and examined for their potential in cranial bone defect healing 2. Histomorphometry and X-ray micro-computed tomography analysis revealed greater bone volume and bone formation area in case of the E7-BMP-2 peptide loaded hybrid nanofiber aerogels. Finally, a combinatorial approach by integrating electrospinning and electrospray microdripping was developed to fabricate nanofiber microspheres 3. The nanofiber microspheres elicited enhanced proliferation and differentiation of stem cells in comparison to solid microspheres. Conclusion. We have demonstrated the fabrication of new forms of electrospun nanofiber materials based on traditional electrospun nanofiber mats. We also demonstrated their potential applications in various biomedical fields. Key Words: Gas-foaming, Expansion, Electrospray, Nanofiber Microspheres Acknowledgements: This work was supported by grants from NIGMS and NIDCR at the NIH (2P20 GM103480, 1R01GM123081, and 1R21DE027516), NE LB606 and startup funds from the University of Nebraska Medical Center. [1] Chen S, Carlson MA, Zhang YS, et al. Biomaterials 2018, 179, [2] Weng L, Boda SK, Wang H, et al. Adv. Healthc. Mater. 2018, 7(10), e [3] Boda SK, Chen S, Chu K, et al. ACS Appl. Mater. Interfaces 2018, 10(30):

17 Electrosprayed poly(lactic-co-glycolic acid) microspheres for drug delivery Jiamian Wang, Leonie Helder, Jansen John, Fang Yang Department of Biomaterials, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. Poly (lactic-co-glycolic acid) (PLGA)-based microspheres have been widely used as drug carriers for controlled release for the treatment of diseases or for tissue regeneration due to the possibility to accurately control the drug release kinetics over periods of days to months [1]. Several techniques have been developed to prepare drug-loaded PLGA microspheres, e.g. solvent evaporation, spontaneous emulsification/solvent diffusion, salting out/emulsification diffusion, supercritical fluid technology and electrospraying [2]. Compared with the other techniques, electrospraying has the advantage of short exposure time of drugs to organic solvents and also a high encapsulation efficiency. As illustrated in Fig. 1, electrospraying is capable of producing diminutive droplets with submicron sizes by means of an electric field, similar to electrospinning. PLGA with drugs is firstly dissolved in a sufficiently conductive solvent and loaded in a syringe connected to a needle. After that, a high voltage is applied between the needle and a collector, and an aerosol of PLGA solution is generated at the tip of the needle. During the flight of the PLGA droplets towards the collector, the solvent evaporates and the resulting PLGA/drug particles can be collected. In this study, we demonstrated that PLGA microspheres with different shapes could be obtained by changing the solvent of PLGA used for electrospraying. The drug release profile could be regulated by the characteristics of the used PLGA, e.g. end groups and molecular weight. We further grafted catalase asymmetrically on the surface of the PLGA microsphere, and the surface modified microspheres showed a self-guided movement in response to the gradient of hydrogen peroxide. Since tumors and wounds both generate high levels of hydrogen peroxide, this type of motorized PLGA microspheres has the potential to be used for the treatment of tumor and wound healing. Figure 1 A schematic diagram of electrospraying setup for preparation of PLGA microspheres Key Words: electrospraying, poly(lactic-co-glycolic acid), drug delivery, microspheres Acknowledgements: We thank the Dutch funding agency the NWO Domain Applied and Engineering Sciences (project number 13844) and China Scholarship Council for the financial support. [1] Makadia HK, Siegel SJ, Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier [J]. Polymers-Basel, 2011, 3(3): [2] Bock N, Dargaville TR, Woodruff MA, Electrospraying of polymers with therapeutic molecules: State of the art [J]. Prog. Polym. Sci., 2012, 37(11):

18 Antifungal functionality of Electrospun Polyacrylonitrile Nanofibers Nafisa Sirelkhatim 1, Arifa Parveen 1, Dennis LaJeunesse 2, Lifeng Zhang 1 * 1 Joint School of Nanoscience and Nanoengineering, North Carolina Agricultural and Technical State University, Greensboro, North Carolina 27401, USA. 2 Joint School of Nanoscience and Nanoengineering, the University of North Carolina at Greensboro, NC 27401, USA Introduction In recent years, integration of electrospun nanofibers in commercial products has been growing exponentially. Electrospun nanofibers have been found in a number of applications such as air/water filtration, performance apparel, drug delivery, scaffold for tissue engineering, and etc. The electrospun nanofibers are already exposed to environment through corresponding commercial products in the form of nanofibrous mat and inevitably in contact with microorganisms including fungi. However, little is known about biological interaction between electrospun nanofibrous mat and fungal cells. In this study, the interactions between electrospun polyacrylonitrile (ESPAN) nanofibrous mat and model fungal cells was investigated. Result Culture progression of S. cerevisiae SK1 cells grown with ESPAN nanofibrous mat and control substrates (blank, PAN film, PAN microfibrous mat) using OD 600 measurement over the course of 8 hours was monitored. SK1 cells demonstrated a standard long growth pattern against time under the circumstances of enough nutrient in all the control cultures. Compared to those control cultures, the cell culture with ESPAN nanofibrous mat, however, showed significantly lower growth capacity from the very beginning, indicating immediate inhibition of S. cerevisiae growth upon contact with ESPAN nanofibrous mat. A cell number drop was even observed at the end of the 8-hour growth period Blank Film Microfibers Nanofibers OD Conclusion Time (hr) Figure 1. OD 600 variation of S. cerevisiae cultures with different PAN substrates within 8-hour growth period. It was discovered for the first time that compared to PAN film and PAN microfibrous mat, ESPAN nanofibrous mats adversely affect the growth, morphology, and viability of yeast cells without any aid from antifungal agents. The antifungal functionality of ESPAN nanofibrous mat provides exciting promise as a next-generation material that control fungal growth through physical contact. 17

19 A rectilinear jet enabled electrospinning of highly aligned fibers for engineering anisotropic tissue applications Yanzhong Zhang* Department of Bioengineering, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai , China. * Due to the intrinsic chaotic jet-whipping phenomenon, how to generate highly aligned fibers and the aligned fibers-based structures is one of the most heavily investigated topics in the community of electrospinning relevant researches and applications. Previously, although many methods comprising largely of employing different collectors (e.g., rotating mandrel) and/or through manipulating the electrical field had been devised and demonstrated to be workable in preparing aligned electrospun nanofibers and assemblies, a method that could permit to deliver facile, rapid, effective, and continuous fiber-aligning capabilities is still a pursuit to be realized. In a conventional electrospinning process, when applying the electric potential above a threshold it usually forms a jet that typically has a rectilinear section (usually very short, sometimes can be up to a few centimetres) followed by a number of bending loops termed bending instability. This thus inspired us to come up with a strategy of extending the rectilinear section to an adequate length for easy fabrication of aligned ultrafine fibers [1]. By formulating the viscoelasticity of some spinning dopes concerned, we have continuously demonstrated that the rectilinear jet enabled electrospinning (termed stable jet electrospinning, SJES) indeed offers a facile solution to the problem of electrospinning aligned fibers; and anisotropic fibrous scaffolds constructed from the SJES brought about improved efficacy in regenerating those anisotropically architectured tissues (Fig. 1) [2-3]. This talk presents an overview of our recent progress on the SJES and its applications in the engineering of anisotropic tissues. Fig. 1 Stable jet electrospinning (SJES) enabled fabrication of a variety of biomimicking aligned fibrous structures, well suitable for engineering of many different tissues with anisotropic architectures (e.g., tendon, ligament, blood vessels, nerve, muscle, cornea, etc.) Key Words: electrospinning, aligned fibers, tissue engineering, regenerative medicine [1] Yuan HH, Zhao SF, Tu HB, et al. Stable jet electrospinning for easy fabrication of aligned ultrafine fibers [J]. J. Mater. Chem. 2012, 22(37): [2] Zhang C, Yuan HH, Liu HH, et al. Well-aligned chitosan-based ultrafine fibers committed tenolineage differentiation of human induced pluripotent stem cells for Achilles tendon regeneration [J]. Biomaterials 2015, 53: [3] Yuan HH, Qin JB, Xie J, et al. Highly aligned core-shell structured nanofibers for promoting phenotypic expression of vsmcs for vascular regeneration [J]. Nanoscale 2016, 8(36):

20 2.2 Smart nanofibers and multifunction materials 19

21 Functional Organic-Inorganic Nanocomposite Fibers via Electrospinning Theodora Krasia-Christoforou Department of Mechanical and Manufacturing Engineering, University of Cyprus, P.O.Box 20537, 1678, Nicosia, Cyprus. Electrospun polymer fibers with diameters in the nano- and micrometer size range attract high attention nowadays due to their unique properties including high surface to volume ratios, composition tailoring and facile introduction of multifunctionalities. Electrospinning can be employed in the fabrication of polymer, ceramic and polymer-based organic-inorganic nanocomposite fibers. The latter are generated through the incorporation of inorganic nanoparticles within polymer fibers during electrospinning or via their anchoring onto the fibers surfaces by following post-modification strategies. This fact renders the technique highly attractive and competitive in biomedical, optoelectronic, environmental, sensing, catalytic and energy-related applications. In this presentation, selected organic-inorganic electrospun nanocomposite fibrous systems will be presented in terms of fabrication, characterization and potential applications. Those include Fe3O4-containing electrospun microfibers and microrods with applicability in the biomedical field [1, 2], catalytic electrospun polymer fibers with embedded metal (Pd, Au) and metal oxide (Cu2O) nanoparticles [3] and nanocomposite fibers with embedded inorganic nanoparticles/nanocrystals exhibiting interesting optical properties, thus allowing their exploitation in sensing, photonics, etc. Keywords: Electrospun nanocomposite fibers, organic-inorganic hybrid materials, magnetic, fluorescent and catalytic fibrous nanocomposites. [1] Savva I, Krasia-Christoforou T Magnetoactive electrospun nanofibers in tissue engineering applications in Nanomaterials and Regenerative Medicine (Eds. Yunfeng Lin, Tao Gong), IAPC- OBP, [2] Savva I, Odysseos A, Evaggelou L, et al. Fabrication, characterization and evaluation in drug release properties of magnetoactive poly(ethylene oxide)-poly(l-lactide) electrospun membranes [J]. Biomacromolecules, 2013, 14(12): [3] Savva I, Kalogirou A, Chatzinicolaou, A, et al. PVP-crosslinked electrospun membranes with embedded Pd and Cu2O nanoparticles as effective heterogeneous catalytic supports [J]. RSC Advances, 2014, 4:

22 Chemically active and hierarchical structured fibers from biopolymers You-Lo Hsieh Fiber and Polymer Science, University of California, Davis, USA. While many sophisticated structures synthesized by living organisms have inspired the creation of novel synthetic materials today, biological materials have not been utilized nor developed to the level as their synthesizd counterparts. Biopolymers are responsible for structural integrity and/or functions of living organisms and are among the most abundant renewable resources. Among the challenges are their isolation and engineering into materials, especially fibers, due to their non-thermoplastic nature and resistance to dissolution or dispersion into homogeneous liquid phase. One approach toward material innovation from biomass is to take advantages of their unique structural and/or chemical attributes while weighing in ways to overcome processing challenges. This paper highlight diverse strategies by which polysaccharides, proteins and polyphenolics can be modified and electrospun into fibers with unique hierarchical structural morphologies (hybrids, sheath-core, hierarchical porosity, etc.) and chemistries (reactive, catalytic, antimicrobial, stimuli-responsive) for applications in catalysis, separation, bioremediation, antimicrobial, chemical/drug-delivery, sensing, imaging, etc. Key Words: biopolymers, cellulose, protein, lignin, chitosan Acknowledgements: Funding from USDA NIFA, USDA Sun Grant, California Rice Research Board, Chevron, and UC Davis AgTech Innovation Center is greatly appreciated. Jiang, F., Y.-L. Hsieh, Dual wet and dry resilient cellulose II fibrous aerogel for hydrocarbon-water separation and energy storage applications, ACS Omega, 3, , Hsieh, Y.-L., Cellulose Nanofibers: Electrospinning and Nanocellulose Self-assemblies, in Advanced Green Composites, Scrivener Publisher & John Wiley and Sons, Vonasek, E., P. Lu, Y.-L. Hsieh, N. Nitin, Bacteriophages immobilized on electrospun cellulose microfibers by non-specific adsorption, protein-ligand binding and electrostatic interactions, Cellulose, 24: (2017). Hu, S., F. Jiang, Y.-L Hsieh, 1D Lignin based solid acid catalysts for direct hydrolysis of crystalline cellulose, ACS Sustainable Chemistry & Engineering, 3: (2015). 21

23 Multifunctional electrospun organic-inorganic hybrid nanofibers Nesrin Horzum Polat 1 and Mustafa M. Demir 2 1 Department of Engineering Sciences, Faculty of Engineering and Architecture, İzmir Katip Çelebi University, İzmir, Turkey. 2 Department of Materials Science and Engineering, Faculty of Engineering, İzmir Institute of Technology, 35430, İzmir, Turkey Colloidal nanoparticles can be advantageously combined with nanofibers to obtain hierarchically structured composite nanofibers. The metal oxide nanoparticles were found to nucleate predominantly at the surface of the fibers during the calcination process of the composite fibers yielded by the simultaneous electrospinning of metal oxide precursors and colloidal nanoparticles. This hierarchical structural organization enhanced the available surface area of the active metal oxide component and improved accordingly the efficiency of the system for catalysis, energy, and filtration/separation applications. The photocatalytic activity of the fibers was exemplified by the successful degradation of a fluorescent dye by ceria/silica and polyacrylonitrile/zeolite composite fibers [1, 2]. Electrospun nanofibers can also be used as electrodes in lithium-ion batteries due to their short diffusion length and rapid intercalation kinetics. Electrochemical performance of lithium cobalt oxide and titania-supported lithium cobalt oxide as cathode materials was investigated. One of the other practical applications of electrospun nanofibers is focused on the separation membranes. The electrospun membranes functionalized with a surface-active gold interface hold great potential for the fast and effective separation of DNA from a simulative serum. They also have the potential to be developed for the separation of DNA biomarkers for diagnosis [3]. Figure 1. Multifunctional electrospun organic-inorganic nanofibers Key Words: colloid-electrospinning, catalyst, lithium ion battery electrodes, separation membranes Acknowledgements: The authors thank Tubitak Marmara Research Center, Energy Institute, TURKEY. This study was financially supported by IKCU Department of Scientific Research Projects with the grant numbers İKÇÜ-GAP MÜH-15 and IKÇU-2018-ÖDL-MÜMF [1] Horzum N, Muňoz-EspíR, Glasser G, et al. Hierarchically Structured Metal Oxide/Silica Nanofibers by Colloid Electrospinning. ACS Applied Materials & Interfaces, 2012, 4(11): [2] Özdemir G.K, Bayram A, Kılıç V, et al. Smartphone-based Detection of Dyes in Water for Environmental Sustainability. Analytical Methods, 2017, 9: [3] Isık T, Horzum N, Yıldız U.H, et al. Utilization of Electrospun Polystyrene Membranes as a Preliminary Step for Rapid Diagnosis. Macromolecular Materials and Engineering, 2016, 301:

24 Essential oils loaded electrospun zein membranes for prolonging shelf life of fruits Yen B. Truong 1, Jonghyun Choi 2, Josh Ince 1, Keith Sharrock 2 and Ilias L.Kyratzis 1 1 CSIRO- Manufacturing, Bag 10 Clayton South, Victoria, Australia. 2 The New Zealand Institute for Plant and Food Research, Private Bag 3230, Waikato Mail Centre, Hamilton, 3240, New Zealand. Fruits have a crucial role in our diet and human life but they are highly perishable products that need optimal post-harvest technologies in order to maintain their storage stability and extend shelf life. Essential oil (EO) is a concentrated hydrophobic liquid containing volatile chemical compounds from plant extracts. Electrospun nanofibers loaded with essential oils or plant extracts have been receiving attention with an increasing number of publications in recent years as summarized by Zhang et al [1]. These essential oils have antimicrobial, anti-inflammatory and anti-oxidant activities, making them promising for employing as active food packaging materials. Zein, a major protein of corn, is a renewable and biodegradable material. The food industry has used zein in coating materials and edible films. It is soluble in aqueous ethanol, which is an ecofriendly solvent for electrospinning [2]. However, due to their volatility and sensitivity to deterioration, EOs may lose efficacy so that higher dosage is necessary. The aim of this study is to load EOs into the zein nanofiber to prolong their efficacies. Two essential oils (peppermint oil /Mentha piprata and lavender/ Lavendula augustifolia) are loaded onto electrospun zein and citric acid-crosslinked zein membranes. The release of the EOs from EO-loaded membranes were monitored using headspace measurement of the total detectable volatile using an in-house rapid volatile measurement device. This revealed a slower release from the EO-loaded membranes than from the EOs by themselves. The potential use of EO-loaded membranes for prolonging the shelf life of fruit evaluated. Figure 1: From corn to electrospun zein and essential oil-loaded zein membranes Key Words: Zein, Essential Oils, Plant Extracts, Food Industry Acknowledgements: The presenting author would like to acknowledge the CSIRO s Research Office for her Research plus Julius Career Award. : [1] Zhang, W.; Ronca, S.; Mele, E. Electrospun Nanofibres Containing Antimicrobial Plant Extracts. Nanomaterials 2017, 7, 42. [2] Book: Nanotechnology in the food, beverage and nutraceutical industries, edited by Qingrong Huang, Woodhead Publishing 2012 pp

25 Electrospun Nanofibre Membrane Research for Environmental, Biomaterial and Energy Applications Ilias L.Kyratzis 1 and Yen B. Truong 1 1 CSIRO- Manufacturing, Bag 10 Clayton South, Victoria, Australia. Nanomaterials and especially nanofibres are set will play a crucial role, in the coming decades, to assist solving human health and environment issues especially as humanity ages, and further urbanises and industrialises. Nanofibres as part of composite structures can play a crucial role in environmental remediation, biomaterials and energy applications. In the environment space new materials and methods of assembly are required that are able to filter fluid media with reduced pressure drops and remove pollutants with high efficiency and selectivity. On the other hand new biomaterials are required to keep people healthy for longer at reduced costs. In the energy space new materials are required which are light weight and capable storing higher energy densities to power the multitude of devices we use in the modern world Electrospinning can play a very useful role in the fabrication of useful devices and components for both of these fast growing areas. This paper presents some of the work undertaken by CSIRO in the environmental biomaterials and energy domains Key Words: Environment, Filtration, Biomaterials, Energy 24

26 Stimulus-Responsive Polyelectrolyte-Complex Fibers Rui-Yan Zhang, Gleb Vasilyev, Eyal Zussman NanoEngineering Group, Faculty of Mechanical Engineering, Technion- Israel Institute of Technology, Haifa, Israel. Key Words: Polyelectrolytes, Fibers, Electrospinning, Stimulation Polyelectrolytes are polymers that carry ionizable groups along the polymer chain. Electrostatic, or ion-pairing, interactions between polyelectrolytes of opposite charge yield cross-linked structures (polyelectrolyte complexes, PECs) with reversible physical junctions. Fibers of polyelectrolytes can be formed using electrostatic forces in the process of electrospinning.1,2 Different stimuli could be used to modify the physical properties of these structures, such as temperature, ph, and ionic strength. Also, osmotically-induced swelling and electrostatic field can modulate their effective modulus and permeability. The central aim of the current study is to explore the electrospun of PEC fibers as stimului-responsive controlled release system. For this goal, we studied the electrospinning of anionic poly(acrylic acid) (PAA) and cationic chitosan (Cs), with different degrees of deacetylation (DD), under extensive elongational flow.3 Cs/PAA nanofibers were obtained, and polyelectrolyte complexation only occurred when fibers were immersed in fluid media of a certain ph (see Sketch). Assembled polyelectrolytes complexes formed a ph-triggered system, as demonstrated by reversible change of the swelling degree, by three orders of magnitude, and a change on the elastic modulus, by two orders of magnitude. Both the swelling degree and the elastic modulus proved sensitive to the DD of Cs. Rheological measurements showed that increased DD of Cs resulted in a decrease in viscosity of both pure Cs and precursor Cs/PAA solutions, attributed to repulsive interactions between ionized amino groups in Cs. At the same time, a DD-dependent change in balance between hydrogen bonding and ion-dipole interactions between the components in Cs/PAA, was responsible for the more pronounced viscosity decrease in these solutions. Biological and biomedical applications such as electrospun scaffolds and drug delivery systems are presented demonstrating the potential of electrospun PECs. [1] Boas M, Gradys A, Vasilyev G, Burman M, Zussman E, Electrospinning Polyelectrolyte Complexes: ph-responsive Fibers [J]. Soft Matter, 2015, 11: [2] Boas M, Burman M, Yarin A, Zussman E, Electrically-responsive deformation of polyelectrolyte complex (PEC) fibrous membrane [J]. Polymer, 2018, 158: [3] Zhang R Y, E. Zaslavski E. Vasilyev G, Boas M, Zussman E, Tunable ph-responsive Chitosan- Poly(acrylic acid) electrospun fibers [J]. Biomacromolecules, 2018, 19(2):

27 Non-flammable and high barrier polymer electrospun membranes Seema Agarwal, Jian Zhu Macromolecular Chemistry, University of Bayreuth, Universitätsstraße 30, Bayreuth, 95447, Germany In this talk, we present new concepts of formation and properties of a rare example of non-flammable (neither sustain flame nor burn with smoke, no polymer dripping), low density, very high thermal stability, flexible and strong polymer membranes. The flammability of polymers is one of the challenges for their use in several applications ranging from day-to-day use in furniture, households and demanding applications in automobiles, aircrafts, construction, protective clothing. We show some new solutions combining electrospinning with material properties for non-flammability. Moreover, novel preparation methods will be discussed for improving the gas barrier properties of polymer membranes using electrospun fibres. Author Biography: Works at University of Bayreuth as academic director and professor with research interest in synthesis of functional speciality polymers, processing methods and nanostructures. She has more than 200 peer-reviewed publications. She is Alexander von Humboldt fellow and got Hermann-Schnell award of German Chemical Society. She is the chief-editor of e-polymers. 26

28 Electrospinning and industrialization toward electrospun fabrics for clothes Chenhui Ding 1, Yin Yu 1, Haoqing Hou 1,2 1Department of Chemistry and Chemical Engineering, Jiangxi Normal University, P.O.Box , Nanchang, China. 2Jiangxi Advanced Nanofiber Technology Co., Ltd. P.O.Box , Nanchang, China. Elctrospun nanofibers has been attracting worldwide intensive attention due to (1) its small diameter and high specific area; (2) the highly porous nanofiber nonwovens; (3) particularly, being made in an easy way [1-2]. The highly porous nonwovens are being used or finding uses in separator for lithium battery [2], filtrations [3] among others. For the above applications, the electrospun nanofiber nonwoven fabric should have good mechanical properties so as to withstand the tearing of the winding tension without breaking during its own industrial production process and subsequent scale application. The poor strength of electrospun nanofiber nonwovens has always been a major factor hindering the industrialization of it. Just recently, Jiangxi Advanced Nanofiber Technology Co., Ltd. has developed a technology to make the strength of electrospun polyimide nanofiber nonwovens reach 80 MPa or more. This technological advancement has brought bright prospects for the mass production and application of electrospun nanofiber nonwovens. The electrospun nanofibers has a diameter of less than one tenth of the diameter of the conventional fiber, a large specific surface area, and a strong moisture wicking function. The small diameter fibers are advantageous for preparing a long yarn with a lower linear density. The electrospun nanofiber long yarn with such larger surface area and lower linear density should have excellent hand feeling and super high moisture wicking function. The woven clothing using such yarns should have more comfortable wearability and elegant ornamental. However, until recently, it has not been possible to produce continuous electrospun nanofiber yarns on a large scale. The main reasons are: 1) the tensile strength of electrospun fibers is poor; 2) the jet velocity is too fast for people to collect nanofibers in an orderly manner; 3) there is no ready-made production equipment for high quality nanofiber yarns. Jiangxi Advanced Nanofiber Technology Co., Ltd. has once again developed a new technology in the electrospinning field to produce high-quality electrospun polyimide nanofiber long yarns in a large scale. The long yarns has a linear density of less than 4.0 tex and a tensile strength of more than 7.0 cn/dtex, and the current daily output of a single machine reaches about 20 kg. It will push electrospinning into the field of textile clothing. Thanks to this epoch-making technological development, one can expect a technological revolution in the traditional textile industry. One can expect that this technological revolution will benefit us all. Key Words: electrospinning, polyimide, electrospun nanofibers, electrospun nanofiber yarn, electrospinning Acknowledgements: This work is supported by National Natural Science Foundation of China (Nos ; ). [1] Reneker DH and Chun I, Nanometre diameter fibres of polymer, produced by electrospinning [J]. Nanotechnology, 1996, 7: [2] Sun B, Long YZ, Zhang HD, et al., Advances in three-dimensional nanofibrous macrostructures via electrospinning [J]. Progress in Polymer Sciences, 2014, 39: [3] Zhang CL and Yu SH, Nanoparticles meet electrospinning: recent advances and future prospects [J]. Chem. Soc. Rev., 2014, 43:

29 2.3 Electrospin technical 28

30 Maximize Neurite Extension on Electrospun Nanofibers for Peripheral Nerve Repair Younan Xia 1,2, Jiajia Xue 1, Tong Wu 1 1 The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, United States ( 2 School of Chemistry and Biochemistry, School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States How to maximize the outgrowth of neurites is vital to enhancing the repair of injured nerves. In a set of studies, we investigated the use of electrospun nanofibers 1 with Schwann cells and biochemical cues to maximize neurite extension and augment peripheral nerve injury repair. We demonstrated the differentiation of bone marrow stem cells into Schwann cells either on laminin-coated, uniaxially aligned nanofibers or in a nanofiber-based nerve guidance conduit (NGC). When co-cultured with PC12 cells or chick dorsal root ganglion (DRG), the as-derived Schwann cells were able to promote the outgrowth of neurites from cell bodies and direct their extension along the fibers, demonstrating the positive impacts of both the neurotrophic effect and the morphological contact guidance. We also developed a temperature-regulated system for the controlled release of nerve growth factor (NGF) to promote neurite outgrowth through the use of a phase-change material (PCM). 2 Upon increasing the temperature to slightly pass the melting point of the PCM by a near-infrared laser, the NGF can be released in a controlled manner. We further demonstrated the functionalization of uniaxially aligned fibers with electrosprayed microparticles made of fatty acids (Figure 1). 3 Through a synergistic effect from the surface roughness arising from the microparticles and the chemical cue offered by the fatty acids, the outgrowth of neurites could be greatly enhanced. Upon integration, these systems hold great promise for applications related to peripheral nerve repair. Figure 1. Schematic illustration showing neurite extension on uniaxially aligned fibers functionalized with electrosprayed microparticles of fatty acids. Key Words: Neurite extension, Stem cell therapy, Topography, Surface roughness, Biochemical cues Acknowledgements: This work was supported in part by a grant from the National Institutes of Health (R01EB020050) and startup funds from the Georgia Institute of Technology. [1] Xue, J., Wu, T., Dai, Y., Xia, Y. Electrospinning and electrospun nanofibers: Methods, materials, and applications. Chem. Rev., 2019, 119, in press. [2] Xue, J., Zhu, C., Li, J., Li, H., Xia, Y. Integration of Phase-Change Materials with Electrospun Fibers for Promoting Neurite Outgrowth under Controlled Release. Adv. Funct. Mater., 2018, 28, [3] Xue, J., Wu, T., Li, J., Zhu, C., Xia, Y. Promoting the Outgrowth of Neurites on Electrospun Microfibers by Functionalization with Electrosprayed Microparticles of Fatty Acids. Angew. Chem. Int. Ed., 2019, 58, in press. 29

31 Preparation Theory and Modular Production Technology of Narrow Distribution Nanofiber Nonwovens Xiaohong Qin 1 * 1 Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, No North Renmin Road, Songjiang, Shanghai , China. , 1.Introduction Electrospinning is one of the most flexible and cost-effective method to produce continuous fibers with diameter ranging from few nanometers to several micrometers. However, the low electrospinning throughput and the wide fiber diameter distribution are two major difficulties. The traditional electrospinning method often used a hollow metal needle to prepare nanofiber with minimal throughput. In recent years, a large number of needleless electrospinning methods had been developed to prepare high-throughput nanofibers, however the distribution of fiber diameter is wide. Such nanofibers with wide diameter distribution have great limitations in application, such as uneven pore size distribution and low filtration efficiency when used as a filter material. Therefore, the study of narrow distribution nanofiber electrospinning technology is of great significance for promoting the functional application of nanofibers in the market. 2. Results and Discussion 2.1. Single jet stretching preparation theory of narrow distribution nanofibers When the electrospinning stable length L satisfy certain equation, the relation of the vertex envelope angle and the envelope angle is stablished. And the tensile refinement models of the /(1 ) 1 3 steady and unstable jet diameter are established: r ~ z and r ~ z.in addition, the rule of the change of the apex envelope angle, the average fiber diameter and the fiber diameter dispersion with the change of induced charge saturation is summarized Multi-jet free liquid surface electrospinning mechanism: When the induced charge saturation is 1, the theoretical model of the wavelength λ, the surface tension γ and the voltage U is constructed, and the relationship between the envelope angle and the wavelength λ is established to control fiber diameter and dispersion The mushroom head spinneret: The optimal edge angle of the spinneret was determined by numerical simulation and the circular spinning surface was found to be superior to the whole circular spinning surface. On this basis, the mushroom head spinneret was invented to ensure the stability and high-curvature of liquid during the movement of the spinneret (30 m/min). The prepared fiber diameter discrete value was maintained at about 15% Modular production technology of nanofiber nonwovens A plurality of sets of spinning modules are designed, and each module is programmed to alternately move along the CD direction of the machine with a set phase difference. Moreover, the longitudinal and transverse tension coordination control technology is adopted. This modular production technology ensuring the uniformity of nanofibers and improving product stability and performance. Each group of modules can independently select different spinning materials, spinning spinnerets and spinning processes to prepare a variety of combined gradient structured nanofiber nonwovens. Key Words: electrospinning, high-throughput, narrow distributed nanofiber, modular production : [1]. Wei L, Yu H, Jia L, et al. High-throughput nanofiber produced by needleless electrospinning using a metal dish as the spinneret[j]. Textile Research Journal,

32 3D/4D electrospinning for energy, catalysis, filtration and biomedical applications Norbert Radacsi 1, Wiwat Nuansing 2,3 1 The School of Engineering, Institute for Materials and Processes, The University of Edinburgh, Robert Stevenson Road, Edinburgh, EH9 3FB, U.K. 2 School of Physics, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand 3 SUT CoE on Advanced Functional Materials (SUT-AFM), Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand Three- and four-dimensional (3D/4D) printing and nanomaterials are revolutionizing the science and engineering of advanced materials, which have key importance to our good healthcare and sustainable development. 3D printing can produce virtually anything that can be designed digitally, and the concept if you can imagine it, you can print it opens up the door to new possibilities, and can potentially lead to advanced materials and products. However, the resolution and fabrication speed of 3D printing are limiting this technology. We have recently developed a new nanoprinting technique that merges conventional 3D printing with electrospinning 1. 3D/4D electrospinning technology is capable of assembling macroscopic 3D (smart) objects consisting of nanofibers hundred times faster than conventional 3D printing technologies. 4D printing can be defined as 3D printing objects that can change their shape over time, or in response to an environmental stimulus 2. Such shape-changing objects can respond to changing parameters, like heat, light, moisture, ph, and can be used in soft robotic systems, smart textiles, drug delivery or biomedical devices. The full potential of 4D printing technology will be achieved when nanoscale manipulation and programming during the production process is possible. We have identified possible ways to make a smart material into 3D nanofibrous scaffolds using the 3D electrospinning apparatus (Figure 1). We have also identified the main potential applications of this technology, and will discuss its use for energy, catalysis, filtration and biomedical applications. Figure 1. Left: Illustration of a 3D electrospinning setup. Right: Illustration of 4D electrospun material changing shape upon temperature or ph change. Keywords: Three-dimensional, 3D, 4D electrospinning, energy, tissue engineering, catalysis, filtration 1. Vong, M. et al. Controlled three-dimensional polystyrene micro- and nano-structures fabricated by three-dimensional electrospinning. RSC Adv. 8, (2018). 2. Tibbits, S. 4D printing: Multi-material shape change. Archit. Des. 84, (2014). 31

33 Bioeletrospinng or Bioprinting? Tao Xu 1 1 Bio-manufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing, China. 2 Tsinghua-Burkeley Shenzhen Institute Precision Medicine and Healthcare Research Center, Guangdong, China As one of additive manufacturing technologies, elctrospinning has been widely applied in tissue engineering and regenerative medicine. Meanwhile, 3D bio-printing has also been developed rapidly according to the current paradigm of utilizing combinations of biomaterial scaffolds and cells for tissue construction. In particular, living tissues maintain inherent multi-cellular heterogeneous structures, and rebuilding of such complex structures requires subtle arrangements of different cell types and extracellular matrix components at specific anatomical target sites. Since 2000 we have initiated the development of the jet-based 3D bioprinting and made lots of efforts in industrial transformation. Recently, we have been working to make further exploration by combining 3D bioprinting and electrospinning. In this paper, we will discuss the progress we have made in this emerging field over the last decade, including the applications from the bench to bedsides. Key Words:Bioprinting, Electrospinning, Tissue engineering, Living cells Acknowledgements: This study is financially supported by the following programs:guangdong Innovative Research Team Program, China (No. 2011S055);the Shenzhen Special Fund for Global Experts Team, China (No.KQTD201209); Key Project of Special Research of Health Development in Beijing Tongzhou District (No. TF-2017-ZD-01-02); Science and Technology Project in Beijing Tongzhou District (No. KJ2017CX039-10). [1] Moroni L, Boland T,, Xu T, et al. Biofabrication: A Guide to Technology and Terminology[J]. Trends in Biotechnology, 2018, 36(4): [2] Li X, Liu L, Xu T, et al.. Research and development of 3D printed vasculature constructs.[j]. Biofabrication, 2018, 10(3): [3] Kunxue Deng, Tao Xu, et al. A novel biomimetic composite substitute of PLLA/gelatin nanofiber membrane for dura repairing[j]. Neurological Research, 2017,39(9):

34 Portable electrospinning devices, solvent free electrospinning and their applications Yun-Ze Long, Xiao-Xiong Wang, Jun Zhang, and Xu Yan College of Physics, Qingdao University, No.308 Ningxia Road, Qingdao , China. Tel: In the past several years, our research group has developed several fabrication techniques to prepare polymeric and inorganic functional superfine fibers. For example, magnetic spinning, melt electrospinning (e-spinning), centrifugal e-spinning, near-field e-spinning, in situ e-spinning, and solvent-free e-spinning (including anion-curing e-spinning, UV-curing e-spinning and thermocuring e- spinning). The superfine fibers with different assemblies such as aligned fibers, wavy fibers, threedimensional fibrous stacking, and twisted fibrous ropes have been obtained. Particularly, some portable or handheld e-spinning devices have been developed to overcome the shortcomings of traditional e-spinning devices (heavy, bulky, and cannot work without outer electric supply). The high voltage of the portable e-spinning device is generated from static electricity generator, piezoelectric ceramic or high-tension conversion circuit. The applications of theses portable e-spinning devices in flexible/stretchable devices, rapid hemostasis, wound dressing, and nonsuture dural repair have been studied. Some electrospinning devices have been commercialized. Key Words: Portable electrospinning, solvent-free electrospinning, wound dressing, flexible device : [1] Y.Z. Long, M. Yu, B. Sun, et al., Recent advances in large-scale assembly of semiconducting inorganic nanowires and nanofibers for electronics, sensors and photovoltaics, Chemical Society Reviews, 2012, 41(12): [2] B. Sun, Y.Z. Long, H.D. Zhang, et al., Advances in three-dimensional nanofibrous macrostructures via electrospinning, Progress in Polymer Science, 2014, 39(5): [3] S.C. Xu, C.C. Qin, M. Yu, R.H. Dong, Y.Z. Long, et al., A battery-operated portable handheld electrospinning apparatus, Nanoscale, 2015, 7(29): [4] R.H. Dong, C. Qin, Y.Z. Long, et al., In situ precision electrospinning as an effective delivery technique for medical glue with high efficiency and low toxicity, Nanoscale, 2015, 7: [5] R.H. Dong, Y.X. Jia, Y.Z. Long, et al., In-situ deposition of personalized nanofibrous dressing via a handy electrospinning device for skin wound care, Nanoscale, 2016, 8(6): [6] B. Zhang, X. Yan, H.-W. He, M. Yu, X. Ning, and Y.Z. Long, Solvent-free electrospinning: opportunities and challenges, Polymer Chemistry, 2017, 8(1): 333. [7] X.X. Wang, W.Z. Song, S. Ramakrishna, Y.Z. Long, et al., Bionic single-electrode electronic skin unit based on piezoelectric nanogenerator, ACS Nano, 2018, 12(8): [8] H. Qiu, Y.Z. Long, et al., Calibration-free self-powered sensor for vital sign monitoring & finger tap communication based on wearable triboelectric nanogenerator, Nano Energy, 2019, 58:

35 2.4 Nanofiber for catalyst 34

36 Electrospun nanofibers for catalytic applications Xiaofeng Lu Alan G. MacDiarmid Institute, College of Chemistry, Jilin University, 2699 Qianjin Street, , P. R. China. Over the past few years, electrospun nanofibers have shown a large number of applications in varied fields including gas and liquid filtration, food packaging, electronic devices, sensing and biosensing, catalysis, adsorption, oil-water separation, biomedicine, energy storage and conversion, etc. Recently, it is a great challenge to develop highly efficient and stable bifunctional non-noble metal electrocatalysts for water splitting. Herein, we present the fabrication of functional carbides and sulfides combined with carbon nanofibers (CNFs) for both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in acidic and alkaline electrolytes. Owing to the unique morphology and structure, electrochemical active surface area, high conductivity of the CNFs, and the synergistic effect between the components, the prepared Ni-Mo 2 C/CNFs and CoS 2 2 exhibited superior electrocatalytic activity for both HER and OER. These electrocatalysts also displayed an excellent HER and OER stability. In addition, in recent years, electrospun nanofibers-based artificial enzyme mimics have gained increasing attention due to their high stability against harsh environmental conditions, tunable catalytic activities, and low cost of preparation compared with natural enzymes. Here we present several facile strategies for the synthesis of varies kinds of hybrid nanofibers as enzyme mimics, showing a superior catalytic activity compared with individual components due to the synergistic effect. Based on the enzyme-like activity of the electrospun nanofibers, a series of sensing platforms have been constructed. In conclusion, this work presents the fabrication of low-cost and high-efficient functional electrocatalysts and enzyme-like catalysts with the potential to exert their applications in energy storage and conversion as well as colorimetric sensing. Key Words: Electrospinning, nanofibers, electrocatalysis, enzyme-like catalysis, synergistic effect Acknowledgements: This work was financially supported by the National Natural Science Foundation of China ( , , ). [1] Li M, Zhu Y, Wang H, et al. Ni Strongly Coupled with Mo 2 C Encapsulated in Nitrogen-Doped Carbon Nanofbers as Robust Bifunctional Catalyst for Overall Water Splitting [J]. Adv. Energy Mater., 2019, 9: [2] Zhu Y, Song L, Song N, et al. Bifunctional and Efficient CoS 2 2 Core-Shell Nanofiber Electrocatalyst for Water Splitting [J]. ACS Sustainable Chem. Eng., 2019, 7: [3] Song W, Zhao B, Wang C, et al. Functional Nanomaterials with Unique Enzyme-like Characteristics for Sensing Applications [J]. J. Mater. Chem. B, 2019, 7: [4] Chi M, Chen S, Zhong M, et al. Self-templated Fabrication of FeMnO 3 Nanoparticle-Filled Polypyrrole Nanotubes for Peroxidase Mimicking with a Synergistic Effect and their Sensitive Colorimetric Detection of Glutathione [J]. Chem. Commun., 2018, 54: [5] Song N, Ma F, Zhu, Y, et al. Fe 3 C/Nitrogen-Doped Carbon Nanofibers as Highly Efficient Biocatalyst with Oxidase-Mimicking Activity for Colorimetric Sensing, ACS Sustainable Chem. Eng., 2018, 6: [6] Gao M, Lu X, Chen S, et al. Enhanced Peroxidase-like Activity of Mo 6+ -Doped Co 3 O 4 Nanotubes for Ultrasensitive and Colorimetric L-Cysteine Detection, ACS Appl. Nano Mater., 2018, 1:

37 Polymer derived ceramics fibers for functional applications Yongpeng Lei 1 Yingde Wang 2 1 State Key Laboratory for Powder Metallurgy, Central South University, Changsha , China; 2 Science and Technology on Advanced Ceramic Fiber and Composites Laboratory, National University of Defense Technology, Changsha , China. Polymer derived ceramics (PDCs) route has received tremendous attention in the design and fabrication of non-oxide ceramics. Up to now, it is a challenge to prepare quasi-1d ceramics fibers. Here, several kinds of SiC fibers via electrospinning combined with PDCs were designed and constructed, showing great potential in functional applications under harsh condition. 36

38 Influence of calcination on the morphology and crystallinity of titanium dioxide nanofibers towards enhancing photocatalytic dye degradation Joshua Zheyan SOO 1, Bee Chin ANG 2, Boon Hoong ONG 1 1 Nanotechnology & Catalysis Research Centre, Institute for Advanced Studies, University of Malaya, Kuala Lumpur, Malaysia. 2 Centre of Advanced Materials, Department of Chemical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia. The development of titanium dioxide (TiO 2) nanostructures with superior morphology and crystallinity is crucial for the photocatalytic degradation of textile dyes. This study highlights the evolution in the morphology and crystallinity of electrospun TiO 2 nanofibers using polyvinylpyrrolidone (PVP) support in relation to applied calcination temperature, and their influence towards the photocatalytic dye degradation performance of the material. Results showed distinct differences in the thermal decomposition patterns of (PVP) on the fiber surface and the inner core, where it is dependent on the presence of oxygen. These differences drastically affect the morphology of the obtained fibers especially its surface area and porosity. Crystallinity of the embedded TiO 2 particles increases with higher calcination temperature which contributes to higher photocatalytic performance. Highly mesoporous nanofibers with crystalline anatase TiO 2 particles, together with fiber diameter of ± 6.30 nm and surface area of m 2 g -1 are obtained at 500 C. The combination of these properties produced the best photocatalytic dye degradation rate constant of min -1 and min -1 for methylene blue and methyl orange respectively. The performance can be attributed to a combination of high particle crystallinity and fiber porosity and surface area. 37

39 2.5 Nanofiber for energy 38

40 One Dimensional Nanomaterials for Emerging Energy Storage Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan , China. One-dimensional nanomaterials can offer large surface area, facile strain relaxation upon cycling and efficient electron transport pathway to achieve high electrochemical performance. Hence, nanowires have attracted increasing interest in energy related fields. We designed the single nanowire electrochemical device for in situ probing the direct relationship between electrical transport, structure, and electrochemical properties of the single nanowire electrode to understand intrinsic reason of capacity fading. The results show that during the electrochemical reaction, conductivity of the nanowire electrode decreased, which limits the cycle life of the devices.we have developed a facile and high-yield strategy for the oriented formation of carbon nanotubes (CNTs) from metal organic frameworks (MOFs). The appropriate graphitic N doping and the confined metal nanoparticles in CNTs both increase the densities of states near the Fermi level and reduce the work function, hence efficiently enhancing its oxygen reduction activity. We also designed the general synthesis of complex nanotubes by gradient electrospinning, including Li 3 V 2 (PO 4 ) 3, Na 0.7 Fe 0.7 Mn 0.3 O 2 and Co 3 O 4 mesoporous nanotubes, which exhibit ultrastable electrochemical performance when used in lithiumion batteries, sodium-ion batteries and supercapacitors, respectively.our work presented here can inspire new thought in constructing novel one-dimensional structures and accelerate the development of energy storage applications. Key words:one dimensional,nanomaterials, Energy storage,in situprobe [1]. L. Q. Mai, Y. J. Dong, L. Xu et al.single Nanowire Electrochemical Devices [J]. Nano Lett.,2010, 10: [2]. J. S. Meng, C. J. Niu, L. H. Xu, et al. General Oriented Formation of Carbon Nanotubes from Metal-Organic Frameworks [J]. J. Am. Chem. Soc., 2017, 139: [3]. C. J. Niu, J. S. Meng, X. P. Wang, et al.general synthesis of complex nanotubes by gradient electrospinning and controlled pyrolysis[j].nat. Commun., 2015, 6:

41 High Performance Rechargeable Batteries via Electrospinning Route Il-Doo Kim 1 * 1 Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Guseong-dong, Yuseong-gu, Daejeon 34141, South Korea. One dimensional nanomaterials with high surface area and open porosity have been widely applied for energy storage devices including high capacity anode electrode layers, electrochemical capacitors, and catalysts for Li-O 2 cells etc. In particular, Li-O 2 batteries have attracted much attention due to high energy density (3505 Wh kg -1 ) in recent year. However the critical challenges including high charging overpotential, low power density and low round-trip efficiency resulting in poor cycle life still remain unsolved. Especially, the development of efficient air cathode has a great significance for improving overall performance because the key reactions, i.e., oxygen reduction and evolution reaction (ORR/OER), occur at the cathode surface during cell operation. In addition, carbon-based porous nanomaterials have often been employed for air cathodes due to their cost-effectiveness, conductive and light weight properties. However, carbon is unstable in highly oxidative atmospheres, which leads to unwanted side reactions (e.g., the formation of by-products such as Li 2 CO 3 and CO 2 ) that critically degrade the round-trip efficiency and cycle-life of Li-O 2 battery. For stable Li-O 2 battery air cathode, we suggested two straightforward approaches to improve stability of porous, conductive and freestanding carbon nanopaper (CNp) using ALD grown In 2 O 3 overlayer and new air cathode design, catalyst (cobalt nitride (Co 4 N) nanorods)-current collector (carbon nanofiber (CNF) paper) monolithic network, for a free-standing and flexible Li-O 2 battery. In addition, I will introduce the customized battery geometries for miniaturized and wearable electronics by optimized combination of 3D printing, electrospinning, and laser micromachining techniques. We have devised aqueous zinc-ion battery (ZIB) system in the customized geometries which consist of a conductive polyaniline (PANI) coated carbon fiber cathode, a porous separator, and a zinc (Zn) anode. Furthermore, we fabricated a wearable photosensor by shape-conformally integrating a ring-shape battery pack with electronic components to demonstrate the merit of our approach. In this talk, recent advances in electrospun nanofibers based electrodes will be discussed. Key Words: Electrospinning, Battery, Li-O 2 cell, 3D printing 40

42 2.6 Nanofiber for photonic and electronic 41

43 Electrospinning as Additive Manufacturing Technology For Photonics And Electronics Alberto Portone 1, Andrea Camposeo 1, Dario Pisignano 1,2, Luana Persano 1 1 NEST, Istituto Nanoscienze-CNR, Piazza S. Silvestro 12, I Pisa, Italy. 2 Dipartimento di Fisica, Largo Bruno Pontecorvo Pisa, Italy Electrospinning enables the use of a large variety of materials and solvents that can be combined in order to tailor specific properties and functionalities in one-dimensional nanostructures. The electric field-induced stretching of polymer solutions with sufficient molecular entanglements enables the formation of highly long filaments with partial alignment of the molecular chains and enhanced optical and electrical properties with respect to the bulk material. Hybrid nanofibers are especially interesting in this respect, enabling the realization of complex, nanostructured photonic structures, with tailored and exotic absorption and emission properties. Here we report on the design, fabrication, morphological and spectroscopic characterization of hybrid nanofiber embedding nanoparticles, photoresponsive dyes, two-dimensional materials 1 and conjugated polymers/fullerene systems. We focus on the properties of light scattering for lasing applications and all-optical switching 2 waveguiding along the longitudinal nanofiber axis and diffusion and dissociation of photogenerated excitons at the interfaces formed within the electrospun nanofibers 3. Key Words: Hybrid nanofibers, solar cells, photonics, 2D materials Acknowledgements: The research leading to these results has received funding from the European Research Council under the European Union s Seventh Framework Programme (FP/ )/ERC Grant Agreement n (ERC Starting Grant NANO-JETS, and from the European Research Council (ERC) under the European Union s Horizon 2020 research and innovation programme (grant agreement No , xprint ). [1] A. Portone, L. Romano, V. Fasano, R. Di Corato, A. Camposeo, F. Fabbri, F. Cardarelli, D. Pisignano, L. Persano 10, 21748, [2] A. Suzkalski, M. Moffa, A. Camposeo, D. Pisignano, J. Mysliwiec, J. Mater. Chem. C 7, 170, [3] Z. Yang, M. Moffa, Y. Liu, H. Li, L. Persano, A. Camposeo, R. Saija, M. A. Iatì, O. M. Maragò, D. Pisignano, C.-Y. Nam, E. Zussman, and M. Rafailovich, J. Phys. Chem. C 122, 3058,

44 Electrospun nanofibers doped with photo-responsive dyes for light-by-light switching: a new platform for optical logics A. Szukalski, 1 J. Mysliwiec, 2 D. Pisignano, 1,3 A. Camposeo 1 1 NEST, Istituto Nanoscienze-CNR, Piazza S. Silvestro 12, I Pisa, Italy. 2 Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, Wroclaw, Poland. 3 Dipartimento di Fisica, Universitàdi Pisa, Largo B. Pontecorvo 3, I Pisa, Italy. Polymer nanofibers functionalized with optically active compounds and their 2-dimensional and 3- dimensional complex arrays are being developed for a variety of applications, including photonics, optical sensing, and nanoelectronics [1,2]. Nanofibers are almost 1-dimensional nanostructures and can be fabricated by using various synthetic polymers and biopolymers, the latter being particularly suitable for the fabrication of transient photonic systems, namely devices which can be designed to dissolve after operation. Moreover, nanofibers can feature various advantages compared to bulk systems, as the possibility to achieve anisotropic optoelectronic properties such as polarized emission and optical birefringence. Here, we will review our current research efforts aimed at developing electrospinning and other additive manufacturing technologies for the realization of optical systems functionalized with photo-responsive molecules. Investigated optical properties include the photoinduced birefringence and all-optical switching of light, that is demonstrated on timescales of ms, corresponding to switching rates of the order of khz [3]. Key Words: (additive manufacturing, photochromic molecules, biopolymers, electrospinning) Acknowledgements: The research leading to these results has also received funding from the European Research Council under the European Union s Seventh Framework Programme (FP/ )/ERC Grant Agreement no ( NANO-JETS ) and under the European Union s Horizon 2020 Research and Innovation Programme (Grant Agreement no , xprint ) [1] Persano L, Camposeo A, Pisignano D, Active polymer nanofibers for photonics, electronics, energy generation and micromechanics. Prog. Polym. Sci. 2015, 43: [2] Camposeo A, Persano L, Farsari M, Pisignano D, Additive Manufacturing: Applications and Directions in Photonics and Optoelectronics. Adv. Optical Mater. 2019, 7: [3] Szukalski A, Moffa M, Camposeo A, Pisignano D, Mysliwiec J, All-optical switching in dyedoped DNA Nanofibers. J. Mater. Chem. C 2019, 7:

45 Photonic networks of electrospun nanofibers A. Camposeo, 1 A. Portone, 1 M. Gaio, 2 D. Saxena, 2 J. Bertolotti, 3 L. Persano, 1 R. Sapienza, 2 D. Pisignano, 1,4 1 NEST, Istituto Nanoscienze-CNR, Piazza S. Silvestro 12, I Pisa, Italy 2 The Blackett Laboratory, Department of Physics, Imperial College London, London, SW7 2AZ, UK 3 Physics and Astronomy Department, University of Exeter, Stocker Road, Exeter, EX4 4QL, UK 4 Dipartimento di Fisica, Università di Pisa, Largo B. Pontecorvo 3, I Pisa, Italy. Networks and nonwoven mats formed by electrospun nanofibers have intriguing properties, that make them innovative building blocks suitable for diverse applications, such as scaffolds for cell culture, random optical media for photonics and active units of sensing devices [1]. In all these applications, the geometric and topological properties of the nanofiber network can be engineered by advanced electrospinning processes to control the properties of the micro- and macroscopic arrays, namely the porosity, the degree of fiber interconnection, the surface wettability and the exposed surface area among the others. In particular, for photonic applications light interacting with or propagating in 2- dimensional (2D) and 3-dimensional (3D) arrays of electrospun fibers can be either scattered by the individual filaments, trapped in a connected arrays of fiber or amplified in presence of fibers with optical gain. All these phenomena are interesting because they enable a series of novel photonic devices, whose properties can be tailored by the architecture of the network formed by the electrospun nanofibers. Here, we will review recent results from our group, focusing on the development of complex nanophotonic networks made of electrospun nanofibers. The fibers are composed by a transparent polymer doped with organic chromophores. Additionally, dielectric nanoparticles can be incorporated into the electrospun fibers to further control the light propagation and diffusion in disordered 3D arrays of nanofibers [2]. A novel architecture for laser devices, namely the nanophotonic network laser [3] will be introduced and the properties of this novel light sources will be reviewed, as well as perspective applications in optical sensing, miniaturized light sources and optical communication. Key Words: (random laser, network science, light-emitting nanofibers, electrospinning) Acknowledgements: The research leading to these results has received funding from the project PRA_2018_34 ( ANISE ) from the University of Pisa, and from the European Research Council under the European Union s 7th Framework Programme (FP/ ), the ERC Starting Grant NANO-JETS (grant agreement n ). [1] Pisignano D, Polymer Nanofibers, 2013, Royal Society of Chemistry, Cambridge, UK. [2] Montinaro M, Resta V, Camposeo A, Moffa M, Morello G, Persano L, Kazlauskas K, Jursenas S, Tomkeviciene A, Grazulevicius J V, Pisignano D, Diverse Regimes of Mode Intensity Correlation in Nanofiber Random Lasers through Nanoparticle Doping. ACS Photonics 2018, 5: [3] Gaio M, Saxena D, Bertolotti J, Pisignano D, Camposeo A, Sapienza R, A Nanophotonic Laser on a Graph. Nat. Commun. 2019, 10:

46 2.7 Nanofiber for filtration 45

47 Multistructured Superwetting Nanofibers for Controllable Liquid Transportation and Separation Yong Zhao School of Chemistry, Beihang University, Beijing , P. R. China Controlling the liquid flowing behavior through a porous nanofibrous membrane with superwetting property is of great interests for separation of liquid mixture, such as free oil/water mixture, emulsion and organic liquid mixture, is widely required in industry process and environmental protection, but how to separate liquids mixture in a high-efficient, low energy mode is still a challenge. We fabricated a series of superwetting liquid separation membranes with special surface structures as well as proper porosity. We designed a cooperative dual-channel oil/water separation system that combines underwater superoleophobic and superhydrophobic membranes. It overcomes the drawbacks of routine single membrane separation devices and achieves a continuous, high-flux and high-efficiency oil/water separation. Comparing to free oil and water, emulsion are more difficult to be separated because of the small size of dispersion phase, we fabricated a branch-like nanofibrous membranes. The membrane could separate various neutral and strong corrosive acidic, basic, and salty emulsions in a highly efficient manner. Besides oil and water system, more complex organic liquid mixtures separation is of vital importance that not only prevents the secondary pollution, but also enhances the recycling of the organic liquids. We fabricated wettability-tunable nanofibrous membrane composited of high performance fluoro-polymer as matrix and fluorosilane as surface energy regulator, which can be applied in immiscible organic liquid mixture separation. These membranes are expected to become competitive candidate for complex chemical products separation, resource recycling as well as environmental protection. Figure 1. Multi-structured superwetting micro/nanofibers and their applications in controllable liquid transportation and separation. Key Words: Electrospinning, Nanofibers, Hollow structures, Superwettability Acknowledgements: NSFC ( , , , ), the National Natural Science Foundation for Outstanding Youth Foundation, the National Program for Support of Topnotch Young Professionals [1] Liu J C, Yu L J, Yue G C, et al. Thermoresponsive Graphene Membranes with Reversible Gating Regularity for Smart Fluid Control [J]. Adv. Funct. Mater. 2019, [2] Hou L L, Wang N, Wu J, et al. Bioinspired Superwettability Electrospun Micro/Nanofbers and Their Applications [J]. Adv. Funct. Mater. 2018, [3] Liu J C, Wang N, Yu L J, Bioinspired graphene membrane with temperature tunable channels for water gating and molecular separation [J], Nat. Commun. 2017, 8,

48 Electrospun Membranes for Separation of Oil/Water Emulsions Yi Min Lin 2, Chen Song 1, Simon Choong 1 and Gregory C. Rutledge 1 1 Department of Chemical Engineering and 2 Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA USA. Electrospun fiber membranes are remarkable for their combination of submicron fibers, high porosity and highly interconnected pore structure. This combination makes them suitable as microfilters or ultrafilters, where pore sizes on the order of 0.1 to 10 m are required. One such particularly challenging separation is that involving emulsified droplets of oil in water, or vice versa, where the droplet sizes are less than 20 m, and highly stable against aggregation or settling. Such separations arise in the reclamation of waste water, recovery of fracking fluids, clean-up of environmentally damaging oil spills, and on-board purification of transportation fuels. Emulsified oils in such aqueous streams are typically removed by the addition of chemicals to destabilize the emulsion, followed by gravity separation, but the addition of such chemicals is expensive and unattractive environmentally. Compared to the conventional methods, membrane separations are attractive for clean-up of emulsified oil because of the high flux, good oil rejection, compact design and low energy cost. However, the major challenge to the membrane technology is fouling, which leads to reduced flux and increased membrane costs. We have examined the interactions between electrospun fibrous membranes and model emulsions of oil (dodecane) in water [1,2]. The membranes are tested in both dead-end and cross-flow configurations. Precautions are taken to address the compressibility of electrospun membranes. We have studied emulsions stabilized by different types of surfactants, as well as membranes functionalized by different types of surface treatments. In addition to the expected strong dependence of flux and rejection on the relative sizes of fibers and emulsion droplets, one observes significant differences in rates of fouling for the different combinations of surfactants, membranes and filtration configurations. Through a systematic study of model systems, correlations between, and the relative importance of, steric, chemical and electrostatic properties of the membranes and emulsions can be discerned. As part of this work, we also introduce the use of confocal laser scanning microscopy (CLSM) for the direct visualization of oil fouling on electrospun fiber membranes. One such image is shown in Fig 1. For the first time, the accumulation of foulant can be monitored in four dimensions (including temporally). Qualitative differences are observed as a function of both chemistry and time of separation. The results are consistent with blocking models in which a graduate transition occurs in the mechanism of fouling. We believe that such direct visualization of oil accumulation within the porous structure of the membrane can offer new insights into the nature of fouling in oil/water emulsion separations. Key Words: (emulsion, membrane, fouling, visualization) Acknowledgements: Funding for this project was provided in part by the Cooperative Agreement between Masdar University, and Massachusetts Institute of Technology (MIT). Figure 1. CLSM image of dodecane droplets (green) accumulated upon and within and electrospun fiber mat of nylon fibers. [1] Choong, L.T., Lin, Y.M., Rutledge, G.C. Separation of oil-inwater emulsions using electrospun fiber membranes and modeling of the fouling mechanism. J. Membr. Sci., 2015, 484: [2] Lin, Y.M. Rutledge, G.C. Separation of oil-in-water emulsions stabilized by different types of surfactants using electrospun fiber membranes, J. Membr. Sci., 2018, 563:

49 Electrostatically assisted centrifugal spinning for continuous collection of nanofibers Kai Weng 1, Fang Li 1, Xuejiao Tao 1, Yuman Zhou 1, Pingping Yuan 1, Weili Shao 1,2, Jianxin He 1,2 1 Zhongyuan University of Technology Textile Institute, Zhengzhou,Postal Code , China. 2 Collaborative Innovation Center of Textile and Garment Industry, Henan Province, Zhengzhou , China. Abstract: Inspired by the centrifugal rotary machine, this paper designed a new method to continuous preparation of highly oriented nanofibers with a high production. The nanofibers is stretched and formed by the combine force of electric field force and centrifugal field; The highly oriented nanofibers was collected through the negative-pressure and high speed rotating centrifugal force. Moreover, the mechanical stretching model of viscoelastic jet during centrifugal electrospinning is establishes, and the spinning parameters of rotating speed, solution concentration, voltage, spinning distance is discussed. Analyzing their influence on orientation, microstructure and mechanical properties of nanofibers. This result shows, the diameter of obtained nanofibers is distributed from 100 to 300 nanometer and the fiber production is g/h. This paper will provide a theoretical study for the industrialization of nanofiber production. Figure 1. (a) Diagram of centrifugal electrostatic spinning. (b) SEM image of PAN. (c) Fiber diameter distribution diagram. (d) Optical image of spinning Key words: Centrifugal electrostatic spinning, Nanofiber, Mechanism, High production [1] Hashemi A R, Pishevar A R, Valipouri A, et al. Numerical and experimental study on the steady cone-jet mode of electro-centrifugal spinning[j]. Physics of Fluids, 2018, 30(1): [2] Chang WM, Wang CC and Chen CY. The combination of electrospinning and forcespinning: effects on a viscoelastic jet and a single nanofiber. Chem Eng J 2014; 244:

50 3. Oral 3.1 Nanofiber for medical and biology 49

51 Promoting Directed Neurites Outgrowth and Schwann Cells Migration by Harnessing Decellularized Matrix on Electrospun Nanofibers for Peripheral Nerve Reinnervation Shihao Chen 1, Zilong Rao 1, Ying Bai 2*, and Daping Quan 1,2* 1 PCFM Lab, GD HPPC Lab, School of Chemistry, Sun Yat-Sen University, Guangzhou , China. 2 GD Functional Biomaterials Engineering Technology Research Center, School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou , China. Synergistic intercellular interactions have been widely acknowledged in tuning functional cell behaviors in vivo, which inspire the development of many scaffolds for regenerative medicine. The Schwann cells, for instance, have shown their effective guidance on neurites outgrowth. To demonstrate the promotion of the Schwann cell-neurite synergistic interaction by nerve extracellular matrix mimicking biomaterials composite in vitro, a cell culturing platform was established using random or aligned electrospun poly(l-lactic acid) nanofibers and decellularized matrix gel from porcine peripheral nervous tissue (pdnm-gel), which served as substrates for dorsal root ganglion(drg) culturing. The Schwann cells migration was highly facilitated by the pdnm-gel coating on the nanofibers, accompanied with a much faster axonal extension. The alignment of the electrospun fibers performed topographical guidance for both neurite outgrowth and Schwann cells migration. Furthermore, the decellularized nerve matrix promoted the Schwann cells to wrap around the bundled neurites, triggering axonal remyelination towards nerve fiber functionalization. Figure.1 Confocal micrographs of DRG cultured on aligned PLLA electrospun film (upper) and aligned electrospun nanofibrous film coated with pdnm-gel (lower) after 7 days. Immunofluorescence staining: neurite (NF200), Schwann cells (S100) and nuclei of cells (DAPI). Key Words: neurite, Schwann cell, decellularized nerve matrix, electrospun nanofiber : [1] Zou J L, Liu S, Sun J H, Quan D P, Zeng Y S, et al. Peripheral Nerve-Derived Matrix Hydrogel Promotes Remyelination and Inhibits Synapse Formation [J]. Adv. Funct. Mater., 2018, 28, [2] Lin T, Liu S, Chen S, Quan D, Liu X, et al. Hydrogel Derived from Porcine Decellularized Nerve Tissue as a Promising Biomaterial for Repairing Peripheral Nerve Defects [J]. Acta Biomater., 2018, 73, [3] He L, Shi Y, Han Q, Zuo Q, Ramakrishna S, Xue W, Zhou L. Surface Modification of Electrospun Nanofibrous Scaffolds via Polysaccharide-Protein Assembly Multilayer for Neurite Outgrowth [J]. J. Mater. Chem., 2012, 22,

52 Peptide Delivery to the Oral Mucosa Using Dual-Layer Electrospun Mucoadhesive Patches Jake G. Edmans 1, Lars S. Madsen 2, Craig Murdoch 1, Martin E. Santocildes-Romero 2, Sebastian G. Spain 3, Paul V. Hatton 1, and Helen E. Colley 1 1 School of Clinical Dentistry, The University of Sheffield, S10 2TA, Sheffield, UK. 2 AFYX Therapeutics, Lergravsvej 57, 2. Tv 2300 København S, Denmark 3 Department of Chemistry, Dainton Building, Brook Hill, Sheffield, S3 7HF The oral delivery of peptides is challenging because of degradation in the gastrointestinal tract. Transmucosal drug delivery is an attractive alternative as this mode of delivery offers several advantages including avoidance of the gastrointestinal tract and hepatic first-pass metabolism, and ease of administration. However, significant obstacles remain for the development of effective formulations including permeation through the epithelial barrier and loss of biological activity. In collaboration with AFYX Therapeutics, we have developed a biodegradable, mucoadhesive oral patch 1 that demonstrates long residence times in vivo 2. The patches are comprised of a two-layer electrospun polymer system composed of a highly bio-adhesive inner layer and an outer saliva-resistant, durable but flexible protective layer. This research aims to further develop the patch for transmucosal delivery of therapeutic peptides. Lysozyme was incorporated into the patches as a model antimicrobial peptide using a variety of solvent mixtures and uniaxial electrospinning. The loading rates and bioactivity were investigated using enzyme kinetics and protein assays to show that bioactivity is highly conserved after electrospinning and that the peptide is released at a desirable rate. The morphology, physical, adhesive, and antimicrobial properties of the patches will also be investigated. The resulting patches serve as a promising proof of concept for peptide delivery to the oral mucosa and may have potential as antiseptic oral wound dressings. Fig 1. (A) Release profile of lysozyme from electrospun polymer patch following immersion in PBS, (B) Loading efficiencies of patches measured using a bicinchoninic acid protein assay and bioactivity relative to lysozyme standards, (C) Scanning electron micrograph of patch. Key Words: Drug delivery, Mucoadhesion, Peptides, Oral medicine Acknowledgements: This research was funded by the EPSRC Centre for Doctoral Training in Polymers, Soft Matter and Colloids (EP/L016281/1) and AFYX Therapeutics. [1] M. E. Santocildes-Romero, L. Hadley, K. H. Clitherow, J. Hansen, C. Murdoch, H. E. Colley, M. H. Thornhill and P. V. Hatton, Fabrication of Electrospun Mucoadhesive Membranes for Therapeutic Applications in Oral Medicine, ACS Appl. Mater. Interfaces, 2017, 9, [2] H. E. Colley, Z. Said, M. E. Santocildes-Romero, S. R. Baker, K. D Apice, J. Hansen, L. S. Madsen, M. H. Thornhill, P. V. Hatton and C. Murdoch, Pre-clinical evaluation of novel mucoadhesive bilayer patches for local delivery of clobetasol-17-propionate to the oral mucosa, Biomaterials, 2018, 178,

53 Synergistic effects of controlled release of 7,8-DHF and aligned PLLA nanofibers on macrophage polarization for neural cell differentiation Ting Guo 1, 3, Jun Li 1, 2, Seeram Ramakrishna 1, 3, Liumin He 1, 2 * 1 MOE Joint International Research Laboratory of CNS Regeneration, Jinan University, Guangzhou , China 2 Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou , China 3 Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore , Singapore Introduction: The inflammatory response induced by spinal cord injury has dual effects: nerve protection and nerve damage. There are several scientific matters that have not been distinctly understood on how to control the inflammatory reaction and further improving nerve regeneration. Research design: Electrospun poly(l-lactic acid) (PLLA) nanofibers of random and aligned fibers loading 7,8-DHF were prepared. Macrophage cells were cultured on the fibers and the cell morphologies, inflammatory factors were investigated. The condition medium was then added into the culture medium of neural stem cells (NSCs). The growth and differentiation of NSCs were studied. Results and discussion: Both of 7,8-DHF and PLLA aligned nanofibers could inhibit LPS-induced inflammation via attenuating the production of pro-inflammatory mediators and promoting the production of anti-inflammatory mediators. Moreover, such effects were significantly enhanced when 7,8-DHF was slowly released from PLLA aligned nanofibers. More NSCs differentiated into neurons with long neurites when M2 condition medium was added. Conclusion: In this study, we provided a biomaterial-based strategy to effectively modulate macrophage polarization toward an M2 phenotype by combining chemical signals and physical cues, and consequently regulated NSCs differentiation. Figure Electrospun PLLA fibers of different patterns and morphologies of macrophage cells cultured. F is the elongation factor of macrophage cells cultured on different fibers. Key Words: electrospinning, aligned fibers, Macrophage cells, Neural stem cells : [1] David S, Greenhalgh A D, Kroner A. Macrophage and microglial plasticity in the injured spinal cord [J]. Neuroscience, 2015, 307: [2] Kong X, Gao J. Macrophage polarization: a key event in the secondary phase of acute spinal cord injury [J]. Journal of Cellular & Molecular Medicine, 2017, 21(5):

54 Needleless curved electrode for high-throughput core/shell fiber production based on emulsion electrospinning Erico Himawan 1, Anna Karpinska 1, and Matej Buzgo 1 1 Research and Development Department, InoCure s.r.o., P.O.Box , Politickych veznu 13, Czech Republic. Classical approach to encapsulate bioactive molecule in nanofiber such as blend electrospinning may not be suitable for sensitive cargo like protein due to possible denaturation in organic solvents. Encapsulation of active compound in the core/shell fiber produced from coaxial electrospinning may avoid such problem. While it is easy to produce coaxial fiber using needle electrode, the very low productivity reduces the feasibility of large-scale production in industry. Needleless coaxial electrospinning using rotating spindle of wires has been developed which may solve the challenge in productivity[1]. However, it may become relatively complex in large scale-up for continuous production setup due to some concern such as solvent drying in liquid bath and complex adjustment of keep the process steady state. A possible alternative to encapsulate sensitive bioactive molecule in nanofiber while at the same time allow high production and still avoid the aforementioned problem from using liquid bath is to use needleless emulsion electrospinning [2], [3]. The presented work showed a novel high-throughput core-shell electrospinning production system developed by InoCure s.r.o.. The system which enable electrospinning of emulsion was able to encapsulate both hydrophilic and hydrophobic compound inside a Poly-e-caprolactone/Polyvinyl alcohol based polymeric scaffold. Potential application of the resulted scaffold in encapsulation and protection of sensitive molecule were verified in vitro. The novel production system allows higher throughput production with high encapsulation ratio and easy to scale up. Keywords: Needleless electrospinning, core-shell fiber, emulsion, encapsulation, growth factor. [1] Forward K M, Flores A, and Rutledge G C. Production of core/shell fibers by electrospinning from a free surface. [J] Chem. Eng. Sci., 2013, 104: [2] Ding Y, Yu M, Sun C, Wu X F, et. al. Needleless emulsion electrospinning for scalable fabrication of core-shell nanofibers. [J] Appl. Polym. Sci., 2014, 131(20): 1-9. [3] Buzgo M, Filova E, Staffa A M, et al. Needleless emulsion electrospinning for the regulated delivery of susceptible proteins. [J] Tissue Eng. Regen. Med., 2018, 12(3): pp Figure 2. Working prototype of needleless curved electrode optimized for high-throughput production. (A) Image of the electrode, (B) Electrical field and (C) Electrostatic potential generated by the electrode. 53

55 Electrospun Nylon-6-Poly(hexanide)/Chitosan-5-Chloro-8-quinolinol core/shell antimicrobial nanofibers for the prevention of surgical site infection on hernia meshes Antonios Keirouz 1, 2, Norbert Radacsi 2, Ren Zulian Qun 1, RenéRossi 1, Giuseppino Fortunato 1 1 Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, CH-9014, Switzerland. 2 The School of Engineering, Institute for Materials and Processes, The University of Edinburgh, Robert Stevenson Road, Edinburgh, EH9 3FB, U.K. Background: Hernia repair infection is a prevalent problem, with an increased number of cases developing post-operation surgical site infection (SSI). Traditionally, a mesh infection is managed by surgical removal of the mesh and administering antibiotics, which vastly increases the chances of hernia recurrence. Nowadays, the use of hernia meshes for hernia repair are textile based constructs that present high mechanical strength, but lack any antibacterial properties. Accordingly, the aim of this study was the development of an adequately mechanically stable construct. Experimental: Nanofibrous scaffolds, developed via co-axial electrospinning can be advantageous towards the assembly of an antimicrobial hernia mesh, as the composed fibers are lightweight and bear a high surface-to-volume ratio, which can accommodate features of diverse materials in a bilayer format. Chitosan (CS) was chosen as the shell polymer, due to its polycationic properties and increased biocompatibility, whereas nylon-6 (PA6) was placed in the core of the fibers to promote an enhanced mechanical integrity. The effect of 5-Chloro-8-quinolinol (5CLO8Q) and Poly(hexanide) (PHMB) was examined. The used drug concentrations were based on the guidance of the Scientific Committee on Consumer Safety of the European Union [1] and previously published work [2]. To achieve a high drug loading efficiency and a sustained release, 5CLO8Q was paired with CS in the shell, and PHMB was paired with PA6 in the core. The antimicrobial composite fibers were thoroughly characterized and their antimicrobial efficiency was demonstrated against two of most commonly associated with SSI bacterial strains; Staphylococcus aureus and Pseudomonas aeruginosa. Results: The developed core/shell fibers presented a homogenous morphology with average fiber diameters of 270± 68 nm, as opposed to 181± 22 nm for drug encapsulated PA6-PHMB and 210± 31 nm for CS-5CLO8Q. The composite fibers expressed an increased hydrophilicity, XPS related the surface chemistry to that of the CS present on the shell and revealed a bead-in-shell morphology. Based on the enthalpies obtained by the DSC, we were able to estimate the amount of PA6 within the core of the core/shell nanofibers (NFs) at 48.5 wt.%. The tensile testing indicated an ample improvement of the young modulus and tensile strength of the composite core/shell fibers, which quadrupled at 217.5± 12.6 MPa and doubled at 20.7± 2.5 MPa, compared to the PA6 and CS-only fibers. A complementary antimicrobial system, where non-fickian sustained release of PHMB from the core of the fibers was observed, with 5CLO8Q improving the polycationic-based bactericidal activity of CS in the shell. The addition of 5CLO8Q augment to elicit the bactericidal activity of the CS-only fibers, whereas the core/shell PA6-PHMB/CS-5CLO8Q nanofibrous constructs, completely suppressed the growth of the two pathogenic Gram (+) and (-) bacterial strains examined. Conclusion: The antimicrobial core/shell system presented an improved synergetic bactericidal activity, eradicating the growth of the bacterial pathogens. The core/shell structure united the unique properties of CS and PA6 to develop a thermochemically, physiologically and mechanically superior composite product. This meticulous study exemplifies how co-axial electrospinning can convince the development of advanced drug-delivery systems based on electrospun NFs, which could be engaged on hernia meshes for the prevention of post-surgical infections. Key Words: co-axial electrospinning, hernia, antimicrobial mesh [1] Scientific Committee on Consumer Safety. Opinion on Polyaminopropyl Biguanide (PHMB) Submission III [J]. Edetorial Publications Office of the European Union, 2018, 10(1): [2] Stoyanova N, Paneva D, Mincheva R, et al. Poly(l-lactide) and poly(butylene succinate) immiscible blends: From electrospinning to biologically active materials [J]. Materials Science and Engineering C, 2014, 41(1):

56 Short electrospun fibers loaded with growth factor as bio-active reinforcing fillers for 3D hydrogel scaffolds Ewa Kijeńska-Gawrońska 1, Alicja Kosik-Kozioł 1, Anna Mróz 1, Wojciech Swieszkowski 1 1 Materials Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology (WUT), Woloska 141, Warsaw, Poland. Electrospun polymeric fibers in range of few nano- to sub-microns are known for their good mechanical properties, high biocompatibility and their bio-active protein carrying capacity [1]. However, electrospun scaffolds produced in standard way as dense mats might possess pores with too low sizes and thus might not be suitable for utilization as vascular scaffolds. On the other hand, tissue engineering scaffolds based on hydrogels are a promising approach for regeneration of the injured region and its vascularization. Despite this, the utilization of this kind of constructs has large limitations connected to the low mechanical properties of hydrogels [2] and non-homogenous dispersion of the small bio-molecules that can be laden within their structure. Thus, we hypothesized that by tailoring morphology and properties of hybrid structure composed of both kinds of material substrates, we can obtain structure with superior properties compared to hydrogels and fibers alone. Therefore, in this study we present an innovative strategy of manufacturing of short electrospun fibers and their enrichment with biological molecules vascular growth factor (VEGF) - towards obtaining of bioactive reinforcing fillers for GelMa-alginate hydrogel vascular scaffolds. We optimized fabrication of short polymeric fibers with length of less than 50 m to further develop most effective methods of their loading with VEGF. Lastly, we fabricated 3D open-porous hydrogel scaffolds loaded with hbm-mscs and short electrospun porous fibers enriched with VEGF using bioprinting method (Fig.1). The studies on the chemical, physical and mechanical properties of the materials, along with growth factor release have been carried out. Fig1. Hydrogels constructs loaded with short electrospun fibers Key Words: short fibers, hydrogel scaffolds, delivery carriers, vascular scaffolds Acknowledgements: This work was financially supported by National Centre for Research and Development within the project BIONIC (STRATEGMED3/305813/2/NCBR/2017). [1] Kijeńska E, Swieszkowski W., 2 - General requirements of electrospun materials for tissue engineering: Setups and strategy for successful electrospinning in laboratory and industry, in: Electrospun Materials for Tissue Engineering and Biomedical Applications,Woodhead Publishing, 2017: pp [2] Kosik-Kozioł A et al. PLA short sub-micron fiber reinforcement of 3D bioprinted alginate constructs for cartilage regeneration. Biofabrication, 2017, 9:

57 Electrospun drug-loaded silk fibroin membrane Xusheng Xie, Gang Li, Xiaoqin Wang, National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou , China. In-stent restenosis caused by tumor ingrowth is a major problem for patients undergoing stent placement because conventional stents often lack sustainable anti-tumor capabilities []. The aim of this work is to develop a drug-loaded silk fibrous (SF) membrane (DSFM) loaded with combined-therapy drugs using electrospinning technologies, which was further coated on a colorectal cancer (CRC) stent. In order to improve treatment effectiveness, a combination of therapeutic drugs, i.e., curcumin (CUR) and 5-fluorouracil (5-FU), was dissolved into SF solution and then electrospun an anti-tumor drugloaded membrane.the morphology, secondary structure, and in vitro drug release profiles of the membranes were characterized. The antitumor efficacy was assessed in vitro and in vivo using a human CRC cell line and tumor-bearing nude mice.the results showed that the release of dual drugs from the three membranes lasted 210 to 400 hours. In vitro and in vivo studies on the nanofibrous memembrane-coated demonstrated improved anti-tumor effects for the CUR/5-FU dual drug system which can be attributed to cell cycle arrest in the S phase in association with induced apoptosis in tumor cells by blocking Stat3 and NF-κB signaling pathways, suggesting potential in the treatment of colorectal cancer in the future. In conclusion, the silk fibroin-based drug-loaded membranes can be useful as biomaterials with antitumor function. Fig. 1. Micrographs, fiber diameter distribution, drug releasing property and assessment of the in vitro anti-tumor function of the drug-loaded membranes Key Words: Silk fibroin, electrospinning, curcumin, 5-fluorouracil, nanofibers Acknowledgements: This work was supported by the National Natural Science Foundation of China ( ) and projects with code SYG201638, and [1] Xie X, Zheng X, Han Z, et al. A biodegradable stent with surface functionalization of combinedtherapy drugs for colorectal cancer [J], Advanced Healthcare Materials 2018, 7: [2] Li G, Li Y, Chen G, et al. Silk-based biomaterials in biomedical textiles and fiber-based implants. Advanced Healthcare Materials [J], 2015; 4(8),

58 Electrospun Nanofibrous Scaffolds for Tissue Engineering Xiaoran Li, Bin Ding, and Jianyong Yu Innovation Center for Textile Science and Technology, Donghua University, Shanghai , China. Electrospun nanofibers with a variety of arrays and architectures have been widely used in tissue engineering owing to the better mimicry of the structure and organization of the native extracellular matrix. For example, the aligned electrospun fibers are well-suited for nerve tissue engineering attributed to the guidance of axonal elongation. We have fabricated radially aligned electrospun nanofibers immobilized with continuous gradients of stromal-cell-derived factor-1α (SDF1α) [1]. The SDF1α gradient scaffolds directed and enhanced migration of neural stem cells from the periphery to the center along the aligned electrospun fibers, showing great potential in guiding endogenous neural stem cells to the lesion site during repair of spinal cord injury. As another example, the three dimensional fibrous scaffolds are suitable for bone tissue engineering [2]. We have developed electrospun SiO 2 nanofiber-reinforced chitosan scaffolds with excellent shape recovery capabilities in aqueous solution. Apart from improved stiffness, recovery rate and compression stability, the incorporation of SiO 2 nanofibers accelerated mineralization and directed osteogenic differentiation of human mesenchymal stem cells. The inorganic nanofiber-assembled scaffold showed self-adaptive capability in vivo, and enhanced bone formation in repair of rat calvarial defect. Fig. 1. Radially aligned nanofibers immobilized with SDF1α gradient directed migration of neural stem cells Key Words: Electrospun nanofibers, stem cells, migration, differentiation, tissue engineering Acknowledgements: This work is supported by the National Natural Science Foundation of China (Nos , , and ), the Shanghai Committee of Science and Technology (No ) : [1] Li X, Li M, Sun J, Zhuang Y, Shi J, Guan D, Chen Y, Dai J. Radially aligned electrospun fibers with continuous gradient of sdf1alpha for the guidance of neural stem cells [J]. Small 2016, 12: [2] Si Y, Wang L, Wang X, Tang N, Yu J, Ding B. Ultrahigh-water-content, superelastic, and shapememory nanofiber-assembled hydrogels exhibiting pressure-responsive conductivity [J]. Adv. Mater. 2017, 29:

59 Gene Silencing via PDA/ERK2-siRNA-Mediated Electrospun Fibers for Peritendinous Antiadhesion Shen Liu 1, Fei Wu 4, Shanshan Gu 3, Tianyi Wu 1, Shun Chen 3, Shuai Chen 1, Chongyang Wang 1,Guanlan Huang 5, Tuo Jin 3, Wenguo Cui 2, Bruno Sarmento 4, Lianfu Deng 2, Cunyi Fan 1 1 Department of Orthopaedics, Shanghai Sixth People s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai , China. 2 Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai , China 3 School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai , China 4 I3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, Porto , Portugal 5 Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai , China Sustained delivery of small interfering RNA (sirna) is a challenge in gene silencing for managing gene-related disorders. Although nanoparticle-mediated electrospun fibers enable sustainable gene silencing, low efficiency, loss of biological activity, toxicity issues, and complex electrospinning techniques are all bottlenecks of these systems. Preventing peritendinous adhesion is crucial for their successful use, which involves blocking cellular signaling via physical barriers. Here, a multifunctional, yet structurally simple, cationic 2,6-pyridinedicarboxaldehyde-polyethylenimine (PDA)-mediated extracellular signal-regulated kinase (ERK)2-siRNA polymeric delivery system is reported, in the form of peritendinous antiadhesion electrospun poly-l-lactic acid/hyaluronan membranes (P/H), with the ability to perform sustained release of bioactive sirna for long-term prevention of adhesions and ERK2 silencing. After 4 days of culture, the cell area and proliferation rate of chicken embryonic fibroblasts on sirna+pda+p/h membrane are significantly less than those on P/H and sirna+p/h membranes. The in vivo results of averageoptical density of collagen type III (Col III) and gene expression of ERK2 and its downstream SMAD3 in the sirna+pda+p/h group are less than those of P/H and sirna+p/h groups. Consequently, sirna+pda+p/h electrospun membrane can protect the bioactivity of ERK2-siRNA and release it in a sustained manner. Moreover, adhesion formation is inhibited by reducing fibroblast proliferation and Col III deposition, and downregulating ERK2 and its downstream SMAD3. Key Words: tendon adhesion, sirna, anti-adhesion electrospun membrane, drug loading. 58

60 ELABORATION OF HONEYCOMB MICROPATTERNED FIBROUS SCAFFOLDS BY ELECTROSPINNING WITH ANISOTROPIC MECHANICAL PROPERTIES FOR SOFT TISSUE ENGINEERING Hugues Mondésert 1, Frédéric Bossard 1, Denis Favier 2 1 Univ. Grenoble Alpes, CNRS, Grenoble INP*, LRP, Grenoble (France) - *Institute of Engineering Univ. Grenoble Alpes 2 Univ. Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAG, F Grenoble, France Tissue engineering technology requires porous biomaterial scaffolds in order to repair and restore biological tissue. Many scientific works have been recently focused on the development of new biocompatible structures that provide mechanical supports to cells and simultaneously allow the flow of biological fluids essential to cell growth and healing. Therefore, scaffolds have to mimic as closely as possible morphology and mechanical properties of the native tissue to substitute. Soft and hard tissues are generally characterized by a complex morphological structure and anisotropic properties that artificial scaffolds would require to host cell 1. Effective approaches to elaborate non-isotropic porous mats with controlled physical properties still need to be developed. A novel method to fabricate fibrous anisotropic scaffolds by template-assisted electrospinning is investigated in this study. Well-shaped 3D micro-architectures were used as conductive collectors to produce ordered fibrous scaffolds with precise and reproducible structures (Fig.1). Polycaprolactone (PCL) electrospun fibers were successfully arranged spatially into honeycomb structures through 3D metal collectors. Fibrous scaffolds present 2x4 mm²wide patterns with low and high fiber density areas. PCL is preferentially collected onto template protrusions creating a local arrangement of the fibers. Mechanical experiments were carried out to analyze anisotropic mechanical behaviors of these new fibrous scaffolds. Two axial directions (fig.2) on the honeycomb patterned mats showed significant different mechanical properties probing the anisotropic character of the fabricated scaffolds. This new versatile method to produce architected porous materials, adjustable to several polymers and structures, will provide appealing benefits for soft regenerative medicine application and the development of custom-made scaffolds. Fig. 1 Fig. 2 Fig. 1 Electrospinning and fiber patterning_ Fig. 2 Axial tensile test of honeycomb mats along two directions (H1 & H2) with local mesh observation Keywords: Electrospinning, scaffolds, tissue engineering, micro-structured biomaterials [1] Engelmayr, G.C., Cheng, M., Bettinger, C.J., Borenstein, J.T., Langer, R., Freed, L.E. Accordionlike honeycombs for tissue engineering of cardiac anisotropy [J] Nature materials, 2008, 7(12):

61 Control of the quiescent-angiogenic state of endothelial cells by tuning the architecture of electrospun Poly (L-lactide ε-caprolactone)-fibrinogen nanofibers Salima Nedjari, Juan Carlos Cassano, Anne Géraldine Guex, Markus Rottmar, Katarina Maniura, Giuseppino Fortunato, RenéR. Rossi Laboratory for Biomimetic Membranes and Textiles, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, 9014 St. Gallen, Switzerland Cardiovascular disease is the leading global cause of death, accounting for 17.3 million deaths per year, a number that is expected to grow to more than 23.6 million by Up to now, artificial implants and particularly artificial small vascular grafts still fail in 40 % of the cases due to inflammation response of endothelial cells expressed by an hyperplasia or by a non-stability of the endothelial cell layer leading to thrombus formation. Ensuring a stable quiescent endothelium layer at the surface of synthetic grafts is highly desirable but is still a major challenge in the field and would be an efficient way to increase the patency of such grafts. The composite nanofibers developed here are based on poly (L-lactide ε-caprolactone) PLCL, a biocompatible copolymer, and on fibrinogen (FBG), an important glycoprotein involved in blood coagulation and wound healing. By tailoring the electrostatic forces during the electrospinning process, we succeeded to develop three types of architectures: random, aligned and honeycomb-like nanofiber membranes. We compared the endothelial response of HUVECs (human umbilical vein endothelial cells) under static and dynamic conditions (0.6 Pa, physiological conditions) on the selected electrospun architectures. By determination of different markers such as VE-Cadherin, Von Willebrand factor and KI67, we studied how the fibrous architectures trigger the inflammation response of endothelial cells and affect thestability of the endothelial layer. Expression of VE-Cadherin after 7 days of HUVECs cell culture on electrospun scaffolds (honeycomb, aligned and random scaffold) under static and dynamic conditions Scale Bar= 100 µm We demonstrated that both architecture and flow trigger the inflammation response of the HUVECs in physiological conditions. Key Words: Architectured scaffolds; honeycomb; endothelium; aligned fibers Acknowledgements: The EMPAPOSTDOCS-II programme has received funding from the European Union s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement number [1] Go A.S., Mozaffarian D., Roger V.L., Benjamin E.J., Berry J.D., Blaha M.J., Dai S., Ford E.S., Fox C.S., Franco S., Heart disease and stroke statistics 2014 update: a report from the American Heart Association, Circulation, 2014, [2] Nedjari S, Awaja F., Altankov G., Three Dimensional Honeycomb Patterned Fibrinogen Based Nanofibers Induce Substantial Osteogenic Response of Mesenchymal Stem Cells, Scientific Reports, 2017, 7,

62 Development of Novel Nanofiber Material to Dress and AccelerateWound Healing Chengxue Qin,Hongtao,Jiang Tingan,Yan Yujun Liu Shandong Hanfang Biotechnology Co. Ltd.. Jinan City, Shandong Province Key words: Compound fluid of Cortex Phellodendri, nanofiber, electrospinning, wound healing. Background:Post-operative wound dressings are widely used in various clinical departments. In the pathophysiological state, there is a high incidence in patients of impairedhealing, especially if the wound is suffering from infection. Traditional dressings only provide a physical barrier to the wounds. In lieu of the products currently in use, our team has utilised advanced nanotechnology [1] combined with a highly efficacious Modernized Traditional Chinese Medicine, (a compound fluid of Cortex Phellodendri, CFCP), to develop biodegradable nanofiber films with antibacterial, anti-inflammatory properties, to aid in the acceleration of wound healing. Method and result: The CFCP-based [2] nanofiber film is prepared by electrospinning silk fibroin and PVA as substrates [3]. The nanofiber film is then integrated with the absorbent pad and the medical tape by a special composite method to form a nano-wound applicator. The surface structure of the nanofiber film is then analyzed by scanning electron microscopy; the mechanical properties (elastic strength and elongation at break) of the nanofiber membrane are measured by a Computer test tensile testing machine (Fig 1). The structure resembles the three-dimensional network structure of the natural extracellular matrix. Such a structure can provide multiple attachment points for cell adhesion, increasing cells stretch, facilitate growth, and promote wound healing.the drug dissolution rate is then examined by High Performance Liquid Chromatography method. The main components of CFCP, forsythin and berberine drug releasereaches the dissolution plateau at 240 min, suggesting that the nanofiber aids in the sustainedrelease of CFCP.No adverse cytotoxicity of nanofiber extract was observed using mouse fibroblast L929 cells examined by MTT test (>70% survival rate). In addition, no sign of skin allergies or intradermal reactions were observed in the test subjects(guinea pigs) after the administration of the novel nanofiber material, confirming the safety profile of the material, in line with regulatory requirements according to the reference of IS Figure 1 The nanofiber membrane is composed of randomly oriented fibers. The SEM image of the nanofiber membrane is analyzed by Image software (mean±sd =723±182 nm). Conclusion: This landmark study demonstrates the efficacy and safety of nano-wound applicators used in combination with Traditional Chinese Medicine (with advanced electrospinning nanotechnology). The novel nanofiber has a small diameter and a large surface area, and the structure resembles the three-dimensional network structure of the natural extracellular matrix. Such a structure allows for improved cell adhesion. The biocompatibility test alsodemonstrates that the nano-wound application is non-cytotoxic, sensitizing nor causes any irritation.the next step in our development pathway will be to carry out the wound healing tests to verify the antibacterial, anti-inflammatory and healing properties of the product in pre-clinical animal models. : [1] Fengli He,Jin He,Dachuan Yin, et al. Research progress on tissue engineering scaffold for preparation of electrostatic spinning[j].materials review, Dec,2014,28(12).1-7 [2] Dong Li,Qinfeng Hu,Daxing Cai, et al. Effect of Compound fluid of Cortex Phellodendri on Immunosuppression of Adipose-derived Mesenchymal Stem Cells.The Chinese journal of dermatovenereology, Jul 2017,31(7): [3] Xiumei Mo,et al. Electrospun nanofibers for tissue engineering scaffolds. Chinese Journal of TissueEngineering Research, Jun, (22 ):

63 Nanostructured biosynthetic mesh for incisional hernia repair: the synergy of chitosan nanofibers and polydeoxyribonucleotides (PDRN) based nanoparticles. Martina Roso 1, Paola Brun 2, Oscar Ornaghi 3, Alessandra Lorenzetti 1, Michele Modesti 1 1 Department of Industrial Engineering, University of Padova, Via Marzolo, Italy. 2 Department of Molecular Medicine, University of Padova Italy. 3 Humana Medical s.r.l. P.za dell artigianato 1/a Abano Terme, Padova, Italy There is a rising demand for materials to replace or augment a patient s native tissue when it has been compromised. Today the use of prosthetic materials has almost completely replaced direct suture procedures, thus contributing to a decrease in the rate of recurrence [1]. Polydeoxyribonucleotides (PDRN), a mixture of short dexoribonucleotide polymers (non-toxic agonist and no antigenic properties) is a well-known stimulator of cell growth that accelerates cell proliferation and can help with the regeneration of skin and tissue [2]. Within this scenario, the present work is meant to show the preliminary results obtained in the research and development of a biosynthetic mesh based on electrospun crosslinked chitosan nanofibers and chitosan-polydeoxyribonucleotides (PDRN) core-shell nanoparticles. The electrospun matrix has been designed for providing support and slow-resorbing fibers and a synergic wound healing effect was promoted by PDRN. A systematic approach was established in order to investigate: - the effect of various parameters on the crosslinking and swelling behavior of chitosan nanofibers; - the effect of various parameters on the formation of the core-shell nanoparticles that were characterized in terms of composition (mean dimensions by light scattering, amount of chitosan by ninidrin assay, amount of encapsulated PDRN by UV vis spectroscopy) and kinetics of PDRN release. - the effect of chitosan nanofibers and core-shell nanoparticles on adhesion strength and proliferation of human dermal fibroblasts (HDF) in culture. The optimized nanostructured mesh showed good mechanical properties, complete stability of the chitosan matrix over 20 days as well as a bimodal PDRN release over 40 days testing. During the first 14 days of culture, HDF cells adhered to core-shell nanoparticles much more strongly and proliferated with higher rate as compared with chitosan nanofibers. Effects on cell proliferation and adhesion were lost after 28 days of culture, matching with the release of PDRN. Key Words: crosslinked chitosan nanofibers, Polydeoxyribonucleotides nanoparticles, biosynthetic mesh, cell adhesion, wound healing [1] Atema JJ, de Vries FE., Boermeester MA. Systematic review and meta-analysis of the repair of potentially contaminated and contaminated abdominal wall defects. Am J Surg,2016, 212: [2] Koo Y., Yun Y. et al.. Effects of polydeoxyribonucleotides (PDRN) on wound healing: Electric cell-substrate impedance sensing (ECIS). Materials Science and Engineering C,2016, 69:

64 Characteristics of cross-linked Thermoplastic Polyurethane/Hyaluronic Acid Membranes Thomas A. Schneiders 1, Magnus Kruse 1, Laura Kreinest 1, Julia Wolf 2, Thomas Gries 1, Stefan Jockenhoevel 2 and Andreas Blaeser 1 1 Institut für Textiltechnik Aachen (ITA), RWTH Aachen University, Aachen, Germany. 2 Dept. Biohybrid & Medical Textiles (BioTex), AME-Helmholtz Institute for Biomedical Engineering & ITA-Institut für Textiltechnik Aachen (ITA), RWTH Aachen University, Aachen, Germany Introduction Aim of the presented project was the development of an electrospun membrane from the materials thermoplastic polyurethane (TPU) and hyaluronic acid (HA). By combining TPU with HA the hydrophilicity of the membrane is improved, while cytotoxicity is decreased compared to TPU membranes. Therefore, the fabricated membrane can be used for applications in tissue engineering, which reach from the design of heart valve leaflets to skin regeneration. 1 Experimental Setup TPU was electrospun from a chloroform/methanol solution. HA respectively was electroblown from an aqueous solution with the aid of heated, pressurized air. Hyaluronic acids with different molecular weights ( kda) were examined for electroblowing nanoparticles. After fabrication the membranes were plasma treated to improve cross-linking between the TPU-fibres and HA particles. The plasma-treatment is conducted in argon-plasma. The chamber is flushed five times with argon. Samples were treated for 5 minutes at a pressure of 0,2 bar. The solubility of HA particles from the membrane was tested with a washing test. Finally, the cytocompatibility and impact of HA incorporation on cell adhesion was studied. Myofibroblasts were cultured for 4 days on samples with the different types of hyaluronic acid. Cell morphology and viability were tested using live/dead staining cells per well were used in the assay. Results and Discussion The mass loss of the membranes after washing was lower in plasma-treated membranes than in untreated membranes. That shows the stabilization and crosslinking between HA and TPU. In the visual analysis of the live/dead assay it was shown, that using HA in the membrane and plasmatreating it improves the cell viability and proliferation. A combination of low ( kda), mid ( kda) and high ( kda) grade HA obtained highest cell viability and proliferation rate for myofibroblasts after 4 days (see graphic below). Conclusion A stable fabrication process for electrospun TPU/HU-membranes was developed. The HA loaded membrane, stabilized via plasma-treatment, showed improved myofibroblast adhesion and viability compared to membranes comprising TPU only. Key Words: thermoplastic urethane, hyaluronic acid, tissue engineering, plasma treatment [1] Bhardwaj N, Kundu S. Electrospinning: A fascinating fiber fabrication technique [J] Biotechnology Advances, 2010, 28:

65 micro/nano fiber membrane with antibacterial and osteogenic dual functions as biomimetic artificial periosteum Rui Shi 1, Min Gong 2, Yuelong Huang 1, Weiyang Li 1, Guangping Li 1, Liqun Zhang 2, Wei Tian 1 1 Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing , P. R. China. 2 Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing , P.R. China The abstract with maximum three key references should be presented in an order of a short introduction, research design, main results and discussion, and finally a conclusion. (Times New Roman, Size 11, regular font) Periosteum, a dense membrane that covers the bone surface, is consisted of cambium and fibrous layer. Due to the significant role of the periosteum in bone regeneration, 2 kinds of novel nanofiber membranes with twin-fiber and core-shell structure were fabricated by a double spinneret electrospinning method[1] and coaxial electrospinning[2], The antibacterial drug moxifloxacin (MOX) and Chinese medicine icariin (ICA) were introduced into PCL/gelatin and PCL micro/nano fibers respectively to endow the membrane with antibacterial and osteoinduction properties. The twin-fiber structure membrane not only acted as carriers for two different drugs with drastically different solubility in the same fiber membrane, but also achieved stepwise and controlled drug release profiles based on different degradation rates of the two fibers matrix and diffusion rates of the two drugs. Results demonstrated that stepwise and controlled drug release profiles were achieved based on the core-shell configuration and disparate degradation rate of PCL and gelatin. Moreover, clear in vitro antibacterial effect and enhancement in osteogenic markers expression including osteocalcin (OCN), type I collagen (COL I) expression and calcium deposition were observed. Also notably, the dual drug-loaded membrane displayed fascinating properties contributing to in vivo bone formation in terms of quality and quantity in a rabbit radius defect model. These results indicate the huge potential of this dual drug loaded twin-fiber membrane as an effective drug release controller and biomimetic multifunctional artificial periosteum to accelerate bone regeneration. Key Words: Artificial Periosteum; Electrospinning; Nanofibers; Antibacterial; Bone Regeneration Acknowledgements: National Natural Science Foundation of China (grant numbers ) [1].Rui Shi, Min Gong, Cheng Chi, Yuelong Huang, et al. Nano Twin-Fiber Membrane with Osteogenic and Antibacterial Dual Functions as Artificial Periosteum for Long Bone Repairing [J]. Journal of Biomedical Nanotechnology, 2019, 15(2), [2].Gong M, Huang C, Huang Y, et al, Zhang L.Core-sheath micro/nano fiber membrane with antibacterial and osteogenic dual functions as biomimetic artificial periosteum for bone regeneration applications. Nanomedicine. 2019, doi: /j.nano

66 Daylight-driven rechargeable antibacterial and antiviral nanofibrous membranes for bioprotective applications Yang Si 1, Gang Sun 2, Bin Ding 1 and Jianyong Yu 1 1 Innovation Center for Textile Science and Technology, Donghua University, Shanghai , China 2 Fiber and Polymer Science, University of California, Davis, Davis, CA 95616, USA. Emerging infectious diseases (EIDs) are a significant burden on global economies and public health. Most present personal protective equipment used to prevent EID transmission and infections is typically devoid of antimicrobial activity. We report on green bioprotective nanofibrous membranes (RNMs) with rechargeable antibacterial and antiviral activities that can effectively produce biocidal reactive oxygen species (ROS) solely driven by the daylight.the premise of the design is that the photoactive RNMs can store the biocidal activity under light irradiation and readily release ROS under dim light or dark conditions, making the biocidal function always online. The resulting RNMs exhibit integrated properties of fast ROS production, ease of activity storing, long-term durability, robust breathability, interception of fine particles (>99%), and high bactericidal (> %) and virucidal (>99.999%) efficacy, which enabled to serve as a scalable biocidal layer for protective equipment by providing contact killing against pathogens either in aerosol or in liquid forms. The successful synthesis of these fascinating materials may provide new insights into the development of protection materials in a sustainable, self-recharging, and structurally adaptive form. Key Words: electrospinning, nanofiber, photoactive, antimicrobial Yang Si, Zheng Zhang, Wanrong Wu, Qiuxia Fu, et al. Daylight-driven rechargeable antibacterial and antiviral nanofibrous membranes for bioprotective applications, Science Advances, 2018, 4, eaar

67 Generation of Circular Gradients of Active Proteins on Radially Aligned Nanofibers for Potential Application in Wound Closure Tong Wu 1,2, Jiajia Xue 1, Xiumei Mo 2, Younan Xia 1,3 1 The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, United States ( 2 State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai , P. R. China 3 School of Chemistry and Biochemistry, School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States Scaffolds functionalized with circular gradients of active proteins are attractive for tissue regeneration due to their enhanced capability to accelerate cell migration and/or promote neurite extension in a radial fashion. Here we report a general method for generating circular gradients of active proteins on scaffolds comprised of radially aligned nanofibers (Figure 1). In a typical process, the scaffold, with its central portion raised using a copper wire to take a cone shape, was placed in a container (upright or up-side-down), followed by dropwise addition of a bovine serum albumin (BSA) solution into the container. As such, a circular gradient of BSA was generated along each nanofiber. The bare regions uncovered by BSA were then filled with an active protein of interest. In demonstrating their potential applications, we used different model systems to examine the effects of two types of protein gradients. While the gradient of laminin accelerated the migration of fibroblasts from the periphery towards the center of the scaffold, the gradient of nerve growth factor promoted the radial extension of neurites from the embryonic chick dorsal root ganglion. This method for generating circular gradients of active proteins can be readily extended to different types of scaffolds to suit wound closure and related applications that involve cell migration and/or neurite extension in a radial fashion. Figure 1. Schematic for generating a circular gradient of active protein along radially aligned nanofibers in two opposite direction. Key Words: radially aligned nanofibers, active protein gradient, fibroblast migration, neurite extension, wound dressing Acknowledgements: This work was supported in part by a grant from the National Institutes of Health (R01EB020050) and startup funds from the Georgia Institute of Technology. [1] Wu, T., Xue, J., Li, H., Zhu, C., Mo, X., Xia, Y. General Method for Generating Circular Gradients of Active Proteins on Nanofiber Scaffolds Sought for Wound Closure and Related Applications. ACS Appl. Mater. Interfaces, 2018, 10(10),

68 Fabrication of vascular grafts made of polylacticacid and silk fibroin by double conjugation electrospinning with excellent mechanical properties and biocompatibility Xi Liao 1, Qian Wang 2, Chunhui Liu 1, Yimin Zhang 1, and Mengyin Li 1 1 Institute for Textile, Zhongyuan University of technology, Postal Code No. 1 Huaihe Road, Shuanghu Economic Development Zone, Zhengzhou City, Henan Province. 2 Institute for Textile, Donghua University, Postal Code North Renmin Road, Songjiang district, Shanghai City. In order to cure cardiovascular diseases effectively, the research of small diameter artificial vascular grafts is extremely urgent. With excellent specific surface area, suitable porosity and pore size, nanofiber has a promising application in biological tissue engineering scaffolds. In this study, core yarn has been spinned through double conjugate electrostatic spinning. The core wire of the core yarn is fine copper wire with smooth surface, and the polylacticacid (PLA) with biological compatibility, biodegradability and excellent mechanical properties is adopted in the cortex. After successful preparation, the core filament was pulled out and vascular grafts was obtained. Moreover, in order to further improve the cell adhesion of vascular grafts, we grafted silk fibroin (TSF) on the surface of vascular grafts by plasma modification. Then structure morphology and mechanical properties of the vascular grafts were characterized. The biocompatibility of vascular grafts was evaluated by culturing endothelial cells (VECs) in vitro. Ultimately, we identified the inner diameter and outer diameter of the vascular grafts that we obtained were about 500μm and 1.1mm respectively. After grafting TSF. the tensile strength of the vascular grafts reached 5.2 MPa, the elongation at break was 390%, and the mechanical properties were excellent. Meanwhile, the hydrophilicity, protein adsorption and blood compatibility of the vascular grafts were excellent. The results of cell culture indicated that PLA/TSF vascular scaffolds could promote the proliferation and adhesion of endothelial cells with good biocompatibility. Figure 1. Preparation of small diameter nanofiber vascular grafts Figure 2. Digital image of fabricated tubular scaffold. Figure 3. SEM image of PLA Key Words: (Electrospinning, nanofibers, polylacticacid, silk fibroin, Vascular tissue engineering) [1] Abdal-Hay A, Bartnikowski M, Hamlet S, et al. Electrospun biphasic tubular scaffold with enhanced mechanical properties for vascular tissue engineering[j]. Materials Science and Engineering: C, 2017:S [2] Wu T, Zhang J, Wang Y, et al. Fabrication and preliminary study of a biomimetic tri-layer tubular graft based on fibers and fiber yarns for vascular tissue engineering.[j]. Mater Sci Eng C Mater Biol Appl, 2018, 82: [3] Norouzi S K, Shamloo A. Bilayered heparinized vascular graft fabricated by combining electrospinning and freeze drying methods[j]. Materials Science and Engineering: C,

69 Frequency (%) Study on the mechanism of heparin-loaded electrospun nanofiber core-shell sutures promoting Achille s tendon healing Yajing Ye, Yaing Zhou, Zhuoyuan Jing, and Dachuan Yin 1 School of Life Science, Northwestern Polytechnical University. P.O.Box , ShaanXi, China. E- Tendon reconstruction surgery is the primary clinical method for repairing acute tendon ruptures. However, following surgery, the efficacy of the postoperative healing process and the recovery of physiological function are inadequate, which are related to insufficient blood supply. Tendon tissue engineering, which has emerged as an alternative method and research hotspot for treating ruptured tendons, is still a long way to go from clinical application. The authors had previously prepared coreshell heparin-loaded nanofiber sutures by near-field electrospinning to repair ruptured rabbit Achilles tendons, significantly improved the healing effect, and increased the mechanical properties of postoperative Achilles tendons. The inflammatory reaction was reduced by adjusting the expression order of Col I and Col III in our heparin-loaded sutures (HL) group comparing commercial sutures (CS) group. In addition, the diameter of collagen fibers in our HL group was thicker than CS group, and its diameter distribution was similar to healthy control (CK) group. The tension strength of HL group was significantly higher than CS group and had no statistic difference with CK group at 6 weeks after operation. Collectively, it was proved that the novel method proposed herein effectively treats tendon rupture and promotes healing and regeneration. It provides an alternative approach for future development of drug-loaded sutures and their application in tendon rupture treatment. CS PPH3.0 CK (a) (b) (c) Collage diameter (nm) (d) Ultrastructure of regenerated tendons in CS group, PPH3.0 group and control group (CK). (a)-(c) Representative cross section images of TEM at 6 weeks after operation. (Scale bar=1μm) (d) distribution of collagen fibril diameters Key Words: electrospinning, sutures, tendon healing, drug-loaded 68

70 Stiffness of Aligned Fibers Regulates the Phenotypic Expression of Vascular Cells Bingcheng Yi, Yanbing Shen, Han Tang, Xianliu Wang, and Yanzhong Zhang* Department of Bioengineering, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai , China. * Tissue-engineered vascular grafts (TEVGs) often exist the problems of thrombogenesis and intimal hyperplasia after long-term implantation; even if well-exercised luminal surface modifications were prior applied [1]. One of the major reasons is the stiffness mismatch between the TEVGs and the native arteries [2]. Electrospun aligned fibers (AFSs) show great promise in constructing smalldiameter TEVGs that mimic the anisotropic architecture of native arteries. An insightful understanding the stiffness effects of AFSs on vascular cell functionality will be beneficial for rational design of the AFSs-based TEVGs. This study aimed to explore fiber stiffness associated effects on functional alteration of the vascular smooth muscle cells (SMCs) and endothelial cells (ECs). The stiffness of highly-aligned fibres was tuned by varying the constituent ratios in electrospinning the core-shell structured poly(l-lactide-co-caprolactone)/poly(l-lactic acid) fibers. This allowed to generate AFSs with the elastic modulus varying from to MPa while remaining similar architectural features (e.g., fibre diameters, orientation degrees) and the same surface chemistry (Fig. 1A-B). Increasing the stiffness of AFSs had no significant influence on the cellular shape but promoted cell proliferation (data not shown), especially enhanced the F-actin fiber assembly in the SMCs (Fig. 1C) and ECs (data not shown). Moreover, higher fiber stiffness miserably modulated the SMC phenotype into a proliferative and pathological state, by significantly down-regulating the contractile markers like -smooth muscle actin ( -SMA) and smooth muscle myosin heavy chain (SM-MHC) (Fig. 1D), and promoting the endothelial-to-mesenchymal transition of the ECs (namely, losing EC phenotypic markers like VE-cadherin and CD31, Fig. 1E-F). This study highlights the effectiveness in manipulating fibre stiffness via forming controllable core-shell structure, and stresses the importance of fiber stiffness as a critical designing parameter in engineering structurally anisotropic TEVGs to achieve long-term patency. Figure 1 (A) Schematic of the stable jet coaxial electrospinning (SJCES) process and fiber morphology of the AFSs produced; (B) Young modulus; (C) Cytoskeletal F-actin stress fibers assembled in SMCs; (D) Expression of SMC contractile markers (α-sma and SM-MHC); (E-F) Expression of EC phenotypic markers (VE-cadherin and CD31). Key Words: vascular smooth muscle cells, endothelial cells, electrospinning, stiffness, shell-core structure. Acknowledgements: This study was supported by the National Key Research and Development Program of China (2016YFC ), the Fundamental Research Funds for the Central Universities ( A3-09), and the National Natural Science Foundation of China ( and ). [1] Radke D, et al. Tissue Engineering at the Blood-Contacting Surface: A Review of Challenges and Strategies in Vascular Graft Development [J]. Adv. Healthc. Mater. 2018, 7(15), No [2] Konig G, et al. Mechanical properties of completely autologous human tissue engineered blood vessels compared to human saphenous vein and mammary artery [J]. Biomaterials 2009, 30(8):

71 Bone remodeling-inspired electrospun organic/inorganic nanofibers with dual delivery of silicate and alendronate for accelerating bone regeneration Yi Wang, 1 Wenguo Cui, 2,* Hongyu Zhang 1, * 1 State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing , China 2 Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai , China * Corresponding authors Bone remodeling, which consists of both the osteoclast-mediated bone resorption process and the osteoblast-mediated bone formation process, is important for bone repair. To date, most of bone tissue engineering scaffolds are focusing on only one aspect of bone remodeling, in particular the bone formation process, while neglecting the synergistic relationship and the balance between bone resorption and bone formation. Therefore, it is a great challenge to develop a highly bioactive bone tissue engineering scaffold that can modulate the bone remodeling process for accelerating bone repair. To tackle this issue, inspired by the balance of bone resorption-formation, here we developed a mesoporous silicate nanoparticle (MSN)- based electrospun polycaprolactone (PCL)/gelatin nanofibrous scaffold to achieve dual delivery of alendronate (ALN) and silicate for a synergetic effect in modulating bone remodeling and thus promoting bone regeneration, where ALN inhibited the bone-resorbing process via preventing guanosine triphosphate-related protein expression, and silicate promoted the bone-forming process via improving vascularization and bone calcification. The developed nanofibers could achieve dual release of ALN and silicate (produced due to the hydrolysis of MSNs) simultaneously. The bone repair data from a rat critical-sized cranial defect model revealed that the developed strategy accelerated the healing time as nearly 3-fold faster (from 12 weeks to 4 weeks), compared with other control groups. In addition, interactive double-factor analysis of variance was evaluated for the data of bone volume and maturity to determine the synergetic effect of ALN and silicate in promoting bone regeneration, and the result clearly proved our hypothesis. In summary, the presented bone remodeling-inspired electrospun nanofibers with dual delivery of ALN and silicate may hold high promise for bone repair in the clinic, and we believe this developed strategy may extend the scope of the design of highly active osteogenic scaffolds in the future. (This work has been invited as Front Cover in the journal Nanoscale) (a) Schematic illustration for the presented design; (b) screenshots of micro-ct images and (c) the corresponding newly formed bone volumes. 70

72 Hybrid electrospun rapamycin-loaded small-diameter vascular grafts effectively inhibit intimal hyperplasia Yang Yang 1, Dong Lei 2, Xiaofeng Ye 1, Zhengwei You 2, and Qiang Zhao 1 1 Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, , China. 2 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, International Joint Laboratory for Advanced Fiber and Low-dimension Materials, College of Materials Science and Engineering, Donghua University, Shanghai , China. Introduction: For the surgical treatment of coronary artery disease, renal artery stenosis and other peripheral vascular disease, there is a significant demand for small diameter (inner diameter < 6 mm) vascular grafts. However, autologous grafts are not always available when the substitute vascular grafts are severely diseased. In our previous work, hybrid small-diameter tissue-engineered vascular grafts (HTEV) were successfully fabricated by combining electrospun polycaprolactone (PCL) and decellularized rats aortas (DRA). But the histological assessments of the grafts revealed development of intimal hyperplasia, indicating potential negative impacts on the long-term patency of the grafts. Research design: To address this challenge, PCL nanofibers blended with rapamycin (RM) were electrospun outside the decellurized vascular graft to fabricate an RM-loaded hybrid tissue-engineered vascular graft (RM-HTEV), endowing the graft with drug delivery function to prevent intimal hyperplasia. Results and discussion: The RM-HTEV possessed superior mechanical properties over DRA and exhibited sustained drug release profile. In order to evaluate the applicability of RM-HTEV in vivo, abdominal aorta transplantation was operated on rats. Doppler-sonography showed that the grafts were functional for up to 8 weeks in vivo. Moreover, histological analysis of the explanted grafts 12 weeks post-implantation demonstrated that RM-HTEV significantly decreased neo-intimal hyperplasia compared with HTEV group, without impairing re-endothelialization and M2 macrophage polarization. Conclusion: Overall, RM-HTEV offers a promising strategy for developing small-diameter vascular grafts with great clinical translational potential. Figure. Schematic and fabrication of RM-HTEV. Key Words: electrospin; rapamycin; intimal hyperplasia, vascular graft, hybrid graft. Acknowledgements: We gratefully acknowledge the financial supports by the Natural Science Foundation of China ( , and ), the Natural Science Foundation of Shanghai (18ZR ), DHU Distinguished Young Professor Program (LZA ), International Joint Laboratory for Advanced fiber and Low-dimension Materials ( ). [1] Gong W, Lei D, Li S, et al. Hybrid small-diameter vascular grafts: Anti-expansion effect of electrospun poly ε-caprolactone on heparin-coated decellularized matrices. Biomaterials, 2016,76:

73 1 Enhanced tenogenic differentiation of hmscs on highly aligned ultrafine PLLA fibers functionalized by type-i collagen and chondroitin sulfate Huihua Yuan 1, Biyun Li 1 and Yanzhong Zhang 2 School of Life Sciences, Nantong University, Nantong, Jiangsu , China. 2 College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai , China. Introduction: Tissue engineering approaches using adult mesenchymal stem cells (MSCs) and scaffolds are considered a promising strategy to addressing unsatisfactory outcomes of tendon repair. Tendon regeneration is greatly dependent on biochemical cues of the tendon extracellular matrix (ECM). Many of tendon ECM proteins have been found to play important roles in tendon differentiation and organization [1]. However, the effect of ECM components such as collagen type 1 (COL1) and chondroitin sulfate (CS) on tenogenesis of human MSCs (hmscs) is not well understood. The objective of this study is to investigate the effect of COL1 and CS functionalized aligned poly(llactic acid) (PLLA) nanofibers on tenogenisis of hmscs. Research design: Highly aligned ultrafine fibers of PLLA with COL1 or COL1-CS coating were prepared by stable jet electrospinning (SJES) [2]. Morphology and mechanical properties of the fiber scaffolds were thoroughly characterized. hmscs were seeded on fibrous substrates coated with COL1 or COL1-CS before analyzed for cell morphology, proliferation, and mrna and protein expression. Results and discussion: Increased cell spread and proliferation were observed on aligned COL1- CS/PLLA fibers compared to those on COL1/PLLA and plain PLLA fibers. Expression of the tendonassociated markers, SCX, TN-C, and COL1 and production of tenomodulin (TNMD) were significantly increased, suggesting the role of COL1-CS/PLLA fibers in directing hmsc differentiation toward the tenogenic lineage. Introduction of mechanical signal generated a synergistic effect on tenogenic differentiation of hmscs. Furthermore, TGFB2, TGFB3, TGFBRII, and Smad3 were upregulated in cells on COL1-CS/PLLA fiber substrates. This suggests that COL1-CS/PLLA ultrafine fibers are capable of driving hmscs toward tenogenic differentiation through the TGFB/Smad3/SCX pathway. Conclusion: In this study, we demonstrate that aligned PLLA ultrafine fibers coated with COL1-CS enhance proliferation and tenogenesis of hmscs, which is mediated by the TGFB/Smad3/SCX signaling pathway. These findings provide new insights into the role of tissue-specific ECM components in guiding cell response during connective tissue regeneration and healing. In addition to serving as an in vitro differentiation model, our findings highlight the importance of providing a bioinstructive microenvironment for eliciting desired cellular response for efficacious tendon tissue regeneration. Key Words: Type 1 Collagen, Chondroitin Sulfate, Aligned Nanofibers, Tendon Differentiation [1] Bi Y M, Ehirchiou D, Kilts TM, et al. Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche [J]. Nat. Med., 2007, 13: [2] Yuan H H, Zhao S F, Tu H B, et al. Stable jet electrospinning for easy fabrication of aligned ultrafine fibers [J]. J. Mater. Chem., 2012, 22 (37):

74 Electrospun Fibers-covered Stent for Endothelization Acceleration Yiran Zhang 1#, Jienan Wang 1#, Yingsheng Cheng, Yueqi Zhu 1 *, Wenguo Cui 2* 1 Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, No. 600, Yishan Road, Shanghai, , P. R.China. 2 Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai , P. R. China. Aneurysmal subarachnoid hemorrhage (SAH) caused high mortality and morbidity. Covered stent was an effective endovascular treatment for complicated aneurysms intractable to endovascular coiling or surgical clipping. However, in-stent restenosis and delayed endothelization were main challenges to its safety. Herein, we designed a bio-functional stent covered by dual-drug loaded electrospun fibers to realize programed vascular endothelial growth factor (VEGF) and paclitaxel (PTX) releases for the early promotion of vascular endothelium and long-term inhibition of stenosis caused by smooth muscle hyperplasia. By encapsulating PTX loaded mesoporous silica nanoparticles (MSNs) into electrospun polylactic acid (PLA) fibers, the release period of PTX was effectively extended. Further, VEGF was conjugated onto the surface of membrane by reaction with polydopamine (PDA) for quick release. In vitro drug release profile revealed at the sustained release of PTX lasting for 63 days without early burst release while VEGF was released rapidlyup to 87.05% within 3 days. Cellular experiments demonstrated that the novel dual-drug loaded scaffold effectively inhibited the proliferation of SMCs after 6 days incubation (155% vs. 303% in control, P=0.039) and prompted endothelial cell proliferation (488% vs. 386% in control, P=0.001). Animal studies showed drugloaded covered stents provided improved immediate and mid-term complete aneurysm occlusion rate compared to bare stents (P<0.05). The drug-loaded covered stents also showed earlier endothelization promotion and better lumen restenosis than normal covered stents did (0% vs. 25%, P=0.29) for 12 weeks follow-up. Altogether, our study developed a programmed dual-drug loaded scaffold that effectively occluded aneurysm sac while its separately VEGF and PTX release was of great help to promote endothelialization and prevent in-stent stenosis. This study provided a new method to improve the biosafety of covered stent insertion for the treatment of intracranial aneurysms. Figure 1. Schematic preparation processes of bio-functional stent. Figure 2. SEM and TEM of electrospun fibers. Angiogram follow up before and after surgical procedure. Figure 3. General and sectional photograph of the aneurysm sample post stent implantation. Key Words: Intracranial aneurysm; Covered stent; Endothelization; Restenosis; Drug elution Acknowledgements: National Nature Science Foundation of China ( , ). [1] Potthoff E, Franco D, et al. Toward a rational design of surface textures promoting endothelialization. Nano letters, 2014, 14 (2), [2] Zhu YQ, Li MH, et al. Treatment of carotid siphon aneurysms by use of the Willis stent graft: an angiographic and histopathological study. European radiology, 2010, 20 (8), [3] Wang Y, Cui W, et al. Bone remodeling-inspired dual delivery electrospun nanofibers for promoting bone regeneration. Nanoscale, 2018, 11 (1),

75 Sandwich-like fibers/sponge composite combining chemotherapy and hemostasis for efficient post-operative prevention of tumor recurrence and metastasis Dongfang Zhou *, Yubin Huang State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun , P. R. China. Intra-operative bleeding is an essential factor leading to the earliest recurrence and tumor metastasis frequently seen after resection of solid tumors. Local drug delivery implants show the unique advantages on post-operative cancer therapy. Local drug delivery implants show the unique advantages on post-operative cancer therapy. Herein, a sandwich-like cisplatin-loaded fibers/sponge composite (CFSC) combining chemotherapy and hemostasis was constructed. The obtained implantable CFSC was able to simultaneously stop bleeding and absorb disseminated tumor cells after tumor resection. More importantly, sustained released cisplatin could kill the local residual tumor cells as well as those concentrated in the CFSC, which significantly inhibited the local tumor recurrence and distant tumor metastasis on the subcutaneous recurrence model and metastasis model. This dual functional implant strategy with low toxicity to healthy organs may inspire new aspects for efficient post-operative cancer therapy. Scheme 1. Schematic illustration of sandwich-like fibers/sponge composite combining hemostasis and chemotherapy for efficient post-operative prevention of tumor recurrence and metastasis. Key Words: implants, hemostasis, chemotherapy, recurrence and metastasis, postoperative cancer therapy Acknowledgements: This work was supported by the financial support from the National Natural Science Foundation of China (No and ). [1] Zhang Z., Kuang G., Zong S., Liu S., Xiao H., Chen X., Zhou D.*, Huang Y.* Sandwich-like fibers/sponge composite combining chemotherapy and hemostasis for efficient post-operative prevention of tumor recurrence and metastasis [J]. Advanced Materials, 2018, 30: [2] Zhang Z., Liu S., Qi Y., Zhou D.*, Xie Z., Jing X., Chen X., Huang Y.* ime-programmed DCA and oxaliplatin release by multilayered nanofiber mats in prevention of local cancer recurrence following surgery [J]. Journal of Controlled Release, 2016, 235:

76 3.2 Smart nanofibers and multifunction materials 75

77 Electrospinning of polycrystalline Na0.44MnO2 nanofiber and singlecrystalline nanorod as cathode materials with excellent rate performance for sodium-ion batteries Bi Fu 1, Jiangyu Li 1,2 1 Shenzhen Key Laboratory of Nanobiomechanics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong , China. 2Department of Mechanical Engineering, University of Washington, Seattle, WA , USA. Electrospinning of nanofibers are widely investigated as cathode materials with enhanced ionic transpot kenetics at high current density, because of the larger specific surface area, porous, high mechanics and one-dimensioncal boundary nanoconfiment. Sodium manganese oxides of nanofibers as cathode materials for sodium-ion batteries are suited to large-scale electrochemical energy storage and conversion, because electrospinning nanofiber is an industral nanotechnology with mass production. Moreover, high mechanics of one-dimensioncal nanostrucutres could relaxed strain caused by the relatively large structure expand resulting form the larger size of sodium ion insertion and deinsertion into electrodes. Na 0.44 MnO 2 exhibited large S-shaped channel benifitical for the sodium ions transport kenectics, yet the slow kinetics and structural degradation limting its rate performance. Na 0.44 MnO 2 nanofiber and nanorod hierarchical structures were synthesised by optimized electrospinning and controlled annealing process. Na 0.44 MnO 2 nanorod delivered excellent cyclic performance with reversible specific capacity of 120mAh/g after 140 cycles, due to the large S-shaped tunnel structure with single-crystalline structure. More importantly, polycrystalline Na 0.44 MnO 2 nanofiber demonstrated superior rate performance with reversible specific capacity of 69.5mAh/g at 10C, because of the one-dimensioncal ultralong and contimuous fibrous network nanostructure. The electrospun polycrstalline Na 0.44 MnO 2 nanofiber and single-crystalline nanorod delivered superior electrochemical performances, making as a promising candidate to partily replace lithium-ion batteries, and enable viable and low-cost sodium-ion batteries for upcoming larger-scale electrochemical energy stotage and conversion. Figure 1. Electrospinning of Na 0.44 MnO 2 nanofiber and nanorod, and the electrochemical performance as cathode materials for sodium-ion batteries. Key Words: Electrospinning, Nanofiber, Electrochemistry, Sodium-ion battery, Na 0.44 MnO 2 Acknowledgements: We acknowledge National Key Research and Development Program of China (2016YFA ), National Natural Science Foundation of China ( , ), Pearl River Talent Plan (2017GC010051), Shenzhen Science and Technology Innovation Committee (JCYJ ), National Science Foundation of Guangdong Province (2017A ). [1] B. Fu, X. Zhou, Y.P. Wang. High-rate Performance Electrospun Na0.44MnO2 Nanofibers as Cathode Material for Sodium-ion Batteries [J]. Journal of Power Sources, : [2] B. Fu, X. Zhou, Y.P. Wang. Co3O4 Carbon Nanofiber Mats as Negative Electrodes for Sodiumion Batteries [J]. Materials Letters, 2016, 170: [3] B. Fu, Y. Su, J. Yu, et. al. Single Crystalline Nanorods of Na 0.44 MnO 2 Enhanced by Reduced Graphene Oxides as a High Rate and High Capacity Cathode Material for Sodium-ion Batteries [J]. Electrochimica Acta, 2019, 303:

78 High Water Barrier Antimicrobial, Antioxidant and Oxygen Scavening Electrospun Biopapers Kelly Johana Figueroa-Lopez 1, Adriane Cherpinski 1, Beatriz Melendez 1, M Pardo-Figuerez 2, C. Prieto 1, Sergio Torres-Giner 1 and Jose M. Lagaron 1 1 Novel Materials and Nanotechnology Group, CSIC, Paterna (Valencia), Spain 2 Bioinicia R&D, Paterna (Valencia), Spain Abstract The main goal of this review presentation was to develop optimized water barrier, antioxidant, antimicrobial and oxygen scavenging mono and multilayered electrospun biopaper based coatings made of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) derived from fruit waste and polycaprolactone (PCL) containing different extracts and nanomaterials using the electrospinning coating technique over conventional cellulose based paper. The resultant electrospun mats were postprocessed to lead to continuous films over which morphology, thermal properties, mechanical, antioxidant, antimicrobial, water vapour barrier, and oxygen absorption properties of the nanocomposites and multilayers were investigated. Acknowledgments Contract grant sponsors: H2020 EU Projects YPACK and ResUrbis Cherpinski, A. et al., 2018, Cellulose 25(2), pp Figueroa, K. et al., 2018, Nanomaterials, 8(4), 199. Cherpinski, A. et al. 2018, Nanomaterials, 8(7),469. Melendez, B. et al., 2018, Front. Sustain. Food Syst. Cherpinski, A. at. al., 2018, Journal of Applied Polymer Science, 135(24),

79 Controlled synthesis of electrospun nanofibers with nanobelt, hollow and lamellar morphologies Oren Elishav 1, Vadim Beilin 1, Gennady E. Shter 1, Gideon. S. Grader 1 1 The Wolfson Department of Chemical Engineering, Technion I.I.T, Haifa , Israel. Electrospinning is a simple approach to produce polymer, ceramic and composite nanofibers of various materials. Ceramic nanofibers with designed morphology, chemical and physical properties are desirable for functional materials. For example, the Fe-Al-O system is used for heterogeneous catalytic reaction converting hydrogen and carbon dioxide (CO 2 ) into liquid fuels. Usually, the electrospinning stage is followed by a thermal treatment step to remove the polymer and obtain the final structure and phase. This step often includes shrinkage, deformation, and phase and morphology changes. Hollow nanofibers, nanobelts and mesoporous fibers receive significant attention due to their superbly high area to volume ratio. Precursor composition, mat thickness and heating rate were found to alter the final morphology from solid nanofibers to lammelar-like nanofiber [1], nanobelts or hollow nanofibers in the Fe-Al-O system. The morphology transformation mechanism governing the formation of hollow nanofibers, nanobelts and lamellar structures as a function of thickness, composition and heating rate is discussed. The proposed mechanism suggests that this structure is possible with other material systems, providing a route to explore other functionalities [2]. The CO 2 hydrogenation catalytic testing of different fibers morphologies shows a relation between performance and fibers' structure. The obtained results are beneficial for production of nanofibers with controlled morphology and underlining the connection between nano-morphology and material's performance. In summary, the presented nanofibers open new research direction in material science and are suitable particularly for applications requiring an accessible large surface area porous media. (C) (D) Figure 1. Electrospun Fe-Al-O morphologies. (A) lamellar (B) lamellar high magnification (C) hollow nanofiber, and (D) nanobelt. Key Words: ceramic, nanofiber, nanobelt, porous material. [1] Elishav O, Beilin V, Shter, G. E, et al. Formation of Core-Shell Mesoporous Ceramic Fibers. J Am Ceram Soc., 2017, 100: [2] Elishav O, Poliak L, Naamat I, et al. Lamellar-like Electrospun Mesoporous Ti-Al-O Nanofibers. Materials, 2019, 12(2):

80 Functional Micro/Nanofibers Prepared by Electrospinning NüWang 1 1 School of Chemistry, Beihang University, Beijing, 10019, China. Abstract: One-dimensional materials like nanowires, nanotubes and nanofibers are one of the most important and representative nanomaterials and have found broad applications in electronics, optics, sensors, catalysis, solar cells, lithium-ion battery and many other fields. It has been found that most special properties of some substances come from their chemical composition, as well as their multilevel micro/nanostructures. Electrospinning is a straightforward and versatile way to fabricate hierarchical structured ultrafine fibers down to micro/nanometer scale. These multilevel structured one-dimensional nanomaterials are attractive because they offer a larger specific area and additional heterogeneous interfaces, which play important roles in enhancing the nano-sized effect. Here, we will introduce our recent achievements in electrospun fibers with hierarchical micro/nanostructrues, including inner porous structures, multichannel structures, surface porous structures and so on. [1] Furthermore, these electrospun multilevel micro/nanostructured materials have wide potential applications in catalysis, energy storage, filtration and adsorption and battery materials. [2-3] Fig. 1. Illustration of electrospun fibers with multilevel micro/nanostructures and their applications. [1] Key Words: electrospinning, micro/nanofibers, wettability, multilevel structure [1] Wu J, Wang N, Zhao Y,* Electrospinning of multilevel structured functional micro-/nanofibers and their applications [J]. Journal of Materials Chemistry A, 2013, 1, [2] Wang N,* Gao Y, Wang YX,* et al. Nanoengineering to Achieve High Sodium Storage: A Case Study of Carbon Coated Hierarchical Nanoporous TiO 2 Microfibers [J]. Advanced Science, 2016, 3, [3] Hou L, Wang N,* Wu J, et al. Bioinspired Superwettability Electrospun Micro/Nanofibers and Their Applications [J]. Adv. Funct. Mater., 2018,

81 Constructing Highly Elastic and Breathable Electronic Skin with Electrospinning Technique Zhaoling Li a,b, *, Jianyong Yu, Bin Ding a Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai , China b Innovation Center for Textile Science and Technology, Donghua University, Shanghai , China * Corresponding author: Abstract: With the rapid advancement of artificial intelligent technology, wearable electronic skins become more and more indispensable to daily life. However, how to fabricate such devices in terms of high elasticity and breathability remains a challenge and highly desired. Here we report a novel route to develop an all-fiber structured electronic skin with electrospinning technique. The fabricated electronic skin was demonstrated to exhibit high pressure sensing with a sensitivity of 0.18 kpa -1 in the detection range of kpa. The fabricated electronic skin can maintain prominent sensing performance and mechanical stability in the presence of large deformation, even when the elastic deformation was up to 50%. The electronic skin was easily conformable on different desired objects for real-time spatial mapping and long-term tactile sensing. Meanwhile, it possessed high gas permeability with a water vapor transmittance rate of kg m -1 d -1. More importantly, the electronic skin was capable of working in a self-sufficient manner and even serving as a sustainable power source to effectively drive small electronics. Holding a collection of compelling features, such as high sensitivity, high elasticity, high breathability as well as being self-powered and scalable fabrication, the presented work paves a new pathway for smart electronic skins, with great potential for smart robots, interactive wearable devices, artificial prosthetics and insensitive patients. Key words: Electronic skin; All-fiber structure; Elasticity and breathability; Pressure sensing; Electrospinning 80

82 Electrospun Fibrous Membranes with Ultrafast Water Transport and Evaporation for Smart Moisture-Wicking Textiles Xianfeng Wang 1,2, Bin Ding 2, and Jianyong Yu 2 1 College of Textiles, Donghua University, Shanghai , China. 2 Innovation Center for Textile Science and Technology, Donghua University, Shanghai 20051, China Moisture transport properties of porous materials play a critical role in maintaining the comfort of body, which are mainly controlled by surface chemistry, structure and morphology of substrate. We provided an overview of our recent works on fibrous membranes for unidirectional moisture transport. (1) We fabricated a dual layer surface-treated nonwoven (NW)/electrospun nanofibrous membranes with excellent unidirectional liquid moisture transport characteristics. In the resultant membranes, surface functionalized NW facilitates the moisture transfer, additionally, nanofibrous layer rapidly pulls out moisture from NW layer that accelerates in the forward direction. (2) In the second work, we report a scalable strategy to create trilayered fibrous membranes with progressive wettability by introducing a transfer layer, which could guide the water transport continuously and prevent the inner layer from being rewetted. The resulting trilayered fibrous membranes exhibited a high one-way transport index and a desired breakthrough pressure in the reverse direction, indicating a continuous directional water transport property. (3) In our recent work, we report a synergistic assembly strategy to create a biomimetic micro- and nanofibrous membrane with antigravity directional water transport and quick-dry performance by combining a multibranching porous structure and surface energy gradient. The resulting fiber-based porous Murray membranes exhibit an ultrahigh one-way transport capability and a desired overall moisture management capability. The successful synthesis of such fascinating materials would be valuable for the design of moisture management textiles with directional water transport property for personal drying applications. Schematic illustration of the biomimetic moisture wicking textiles. Key Words: Electrospun nanofibers, Unidirectional moisture transport, Moisture-wicking textiles [1] Babar A, Wang X, Iqbal N., et al. Tailoring differential moisture transfer performance of nonwoven/polyacrylonitrile-sio 2 nanofiber composite membranes [J]. Adv. Mater. Interfaces, 2017, 4(15): [2] Miao D, Huang Z, Wang X, et al. Continuous, Spontaneous, and Directional Water Transport in the Trilayered Fibrous Membranes for Functional Moisture Wicking Textiles [J]. Small, 2018, 14, [3] Wang X, Huang Z, Miao D, et al. Biomimetic Fibrous Murray Membranes with Ultrafast Water Transport and Evaporation for Smart Moisture-Wicking Fabrics [J]. ACS Nano, 2019, 13,

83 Externally triggered on-demand drug release from stimuli-responsive hydrogel-based electrospun nanofibers and their composites Paweł Nakielski 1, Olga Urbanek 2, Sylwia Pawłowska 1, Tomasz A. Kowalewski 1 and Filippo Pierini 1 1 Department of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, P.O.Box, Warsaw, Poland. 2 Laboratory of Polymers and Biomaterials, Institute of Fundamental Technological Research, Polish Academy of Sciences, P.O.Box, Warsaw, Poland. Pulsatile drug delivery systems are gaining a lot of interest because of their numerous advantages, especially when compared to conventional pharmaceutical dosage forms [1]. These materials are timeand site-specific drug delivery systems which can minimize deleterious side effects of conventional drug administration systems. Nevertheless, the delivery systems that are of particular interest are the ones with reversible on-off switching capability, because they allow the delivery of therapeutic agents at the proper time after a predetermined lag time. Among the polymers used for biomedical applications, hydrogels are a class of materials of particular significance, because they can provide spatial and temporal control over the release of various types of drugs. Stimuli-responsive hydrogels can release drugs on-demand with a fast release rate through different mechanisms. The effectiveness of this process can be maximized using nanostructured materials with a large surface-area-to-volume ratio such as electrospun nanofibers. Current challenges in the development of hydrogel electrospun fibrous nanomaterials lie in the lack of spinnability of pure hydrogel precursor solutions. Addressing this issue, we firstly designed a new core-shell nanofibrous material in which the poly(n-isopropylacrylamide)-derivative hydrogel is confined within a shell of a spinnable polymer (Figure 1a). Alternatively, we developed a scaffold material in which electrospun nanofibers loaded with different bioactive molecules where surrounded by a stimuli-responsive hydrogel (Figure 1b). Morphological and chemical characterization as well as drug release studies were carried out to confirm the material s ability to supply different doses of drugs on demand and to study the release mechanism. Figure 1: (a) Fluorescence micrograph of core-shell electrospun hydrogel-based fibers; (b) scanning electron micrograph of an electrospun nanofibrous mat surrounded by a stimuli-responsive hydrogel. Key Words: Electrospun nanofibers, On-demand drug delivery system, Stimuli-responsive nanomaterials, Hydrogels. Acknowledgements: This work was supported by the National Science Centre (NCN) grant no. 2015/19/D/ST8/ [1] Brudno Y, Mooney D J On-demand drug delivery from local depots [J]. Journal of Controlled Release, 2015, 219: [2] Nakielski P, Pawłowska S, Pierini F, et al. Hydrogel nanofilaments via core-shell electrospinning [J]. PLoS ONE, 2015, 10(6): e

84 Electrostatic Microfluidic Spinning Technique towards Ordered Micro/Nanofibers and Its Application Su Chen* State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, No. 5 Xin Mofan Road, Nanjing , P. R. China. Design and fabrication of ordered micro/nanofibers and fiber microreactors toward practical applications are one of the paramount subjects in a variety of spinning technologies. Herein, taking advantages of microfluidic spinning and electrospinning technique, we propose a new electrostatic microfluidic spinning method to prepare ordered micro/nanofibers based on different micro-chips and electrostatic field. We fabricated a series of one-dimensional ordered nanofiber arrays (conductive graphene composite microfibers, [1] fluorescent microfibers, Janus microfibers) and two-dimensional ordered fiber films [2] (nonwoven fiber membranes, photonic crystal membranes) via this new method. Considering of their remarkable fluorescent, electrochemical and optical properties, we successfully realize practical applications including supercapacitors, microreactors, flexible wearable devices and artificial skin. In addition, we introduce another new solution blowing microfluidic spinning technique to construct ordered micro/nanofibers. The new electrostatic microfluidic spinning technique provide a flexibile and efficient pathway for oriented fabrication of ordered micro/nanofibers, as well as ordered and functional fibrous membranes. Figure 1: Preparation of multi-dimensional microreactor fiber arrays by microfluidic spinning technology Key words: Electrostatic microfluidic spinning, supercapacitors, artificial skin. Acknowledgement: This research was funded by the National Natural Science Foundation of China ( ) and the Ministry of Science and Technology Major Research and Development Program (2016YFB ). [1] Wu X J, Chen S. et al. Microfluidic-Spinning Construction of Black Phosphorus-Hybrid Microfibres for Non-Woven Fabrics toward a High Energy Density Flexible Supercapacitor [J]. Nature Communication, 2018, 9, [2] Xu L L, Wang C F, Chen S. et al. Microarrays Formed by Microfluidic Spinning as Multidimensional Microreactors [J]. Angewandte Chemie-International Edition, 2014, 53,

85 Generalized strategy to fabricate electrospun sponges in water and tailor their hydrophilicity Jun Young Cheong 1, Mahsa Mafi 2, Lothar Benker 2, Jian Zhu 2, Michael Mader 2, Chen Liang 2, Seema Agarwal 2, Il-Doo Kim 1, and Andreas Greiner 2 1 Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea 2 Makromolekulare Chemie II Gebäude NWII, Universität Bayreuth, Universitätsstrasse 30, Bayreuth, Germany Recently, a number of electrospun sponges have garnered significant attention as they exhibit high porosity, low density, and ultralight characteristics, desirable for various applications [1]. Nevertheless, a majority of the currently demonstrated electrospun sponges were synthesized in dioxane [2], which are rather toxic and not environmentally friendly. In this work, we have successfully developed a way to fabricate electrospun sponges in water by adding a suitable additive to disperse the short polymeric fibers well in water and synthesize them into polymeric sponges. The initial short fibers that were not dispersed well in water was dispersed well after incorporation of additives, and such pattern persisted even after addition of polyacrylic acid (PAA) solution. Such fabricated sponges not only show very hydrophilic properties (Figure 1a) but also exhibit zero contact angle (showing complete adsorption of water) (Figure 1b) as well as high water uptakes (Figure 1c). The suggested method here presents a new avenue for fabricating electrospun sponges in water using suitable additives, for various electrospun polymers. Figure 1. Digital camera images of (a) polymeric short fiber in water, (b) after incorporation of additives, and (c) after PAA addition. (d) Contact angle analysis and (e) water uptake analysis with respect to the additive concentration. Key Words: sponge, electrospinning, hydrophilic, short fiber, water [1] Jiang S, Agarwal S, Greiner A, Low-Density Open Cellular Sponges as Functional Materials [J]. Angewandte Chemie International Edition, 2017, 56(49): [2] Jiang S, Uch B, Agarwal S, et al. Ultralight, Thermally Insulating, Compressible Polyimide Fiber Assembled Sponges [J]. ACS Applied Materials & Interfaces, 2017, 9(37):

86 Electrospinning of silica nanofibrous membranes for separation and sensing applications Eva Loccufier 1, Dagmar D hooge 1, Klaartje De Buysser 2, Karen De Clerck 1 1 Department of Materials, Textiles and Chemical Engineering, Faculty of Engineering and Architecture, Ghent University, Technologiepark 70A, 9052 Zwijnaarde, Belgium, 2 Sol-gel Centre for Research on Inorganic Powders and Thin Films Synthesis (SCRiPTS), Department of Chemistry, Faculty of Sciences, Ghent University, Krijgslaan 281 S3, 9000 Ghent, Belgium Electrospinning of polymer nanofibers has been studied extensively and has shown to be possible via stable, reproducible and controllable processes. Studies on ceramic nanofibers are less comprehensive. Ceramic materials are hard and inert and are therefore known for their excellent properties such as high temperature resistance and chemical inertness. These promising characteristics allow ceramic nanofibers to be investigated for various applications such as biological applications, filtration, composites, catalysis and advanced sensors. Recently, our group successfully produced ceramic silica nanofibers without the need of a sacrificing polymer. [1, 2] In contrast to other work, in which a well-spinnable organic polymer is mixed with a metal oxide precursors to facilitate the electrospinning process, direct electrospinning of a sol gel solution of a tetraethyl orthosilicate (TEOS) precursor eliminates the need for a postproduction removal of the organic polymer component. This results in dense silica nanofibers with superior mechanical properties, without a rough and uneven surface of the fibers. In addition and even more important, it offers the benefits of a simple, more tunable material design. In the present work we show the application of these materials towards both sensing materials [1] and advanced purification [2]. The use of dye-functionalized precursors allows to produce versatile colour changing silica membranes that open up the use of simple colorimetric sensors under harsh environments. On the other hand using the precursor functionalities towards a tuning of hydrophobic/hydrophilic nature allows for advanced separation applications. A first proof-of-principle application we will demonstrate is the fast gravity-driven membrane separation of heterogeneous azeotropes. Key Words: silica nanofibers, separation, azeotropes, colour-changing, sensors Acknowledgements: FWO is gratefully acknowledged for funding via a SB PhD grant (1S82918N) [1] E. Loccufier, J. Geltmeyer, L. Daelemans, D. R. D hooge, K. De Buysser, K. De Clerck. Silica Nanofibrous Membranes for the Separation of Heterogeneous Azeotropes Adv. Funct. Mater. 28(44) (2018) art nr [2] J. Geltmeyer, G. Vancoillie, I. Steyaert, B. Breyne, G. Cousins, K. Lava, R. Hoogenboom, K. De Buysser and K. De Clerck. Dye Modification of Nanofibrous Silicon Oxide Membranes for Colorimetric HCl and NH3 Sensing. Adv. Funct. Mater., 26(33) (2016)

87 Structural Control and Applications of Inorganic Oxides by Electrospinning Jianjun Li, and Ye Yuan National Key Laboratory of Science and Technology for National Defence on Advanced Composites in Special Environments, Harbin Institute of Technology, No 2 Yikuang Street, Harbin , People s Republic of China. Introduction: Fabrication and manipulation of matter at the nano- and micrometer level can create new classes of materials with enhanced mechanical, optical, transport, and magnetic properties. Research design: A roller electrospinning technique is combined with sol-gel chemistry to fabricate SiO 2 fibers with long-range periodic structure on conductive substrates. Fe 2 O 3 nanotubes have been successfully prepared by directly annealing electrospun citric acid-based precursor fibers. Results and discussion: According to the experimental results, formation of the one-dimensional periodic silica structure was dependent on the electrical conductivity of the collector substrate. The periodic density seems to be related to the width of silica product. An energy transformation model was proposed to investigate the formation mechanism of this periodic structure. The theoretical simulation indicates that large width-to-thickness ratio of the product and high-energy transformation efficiency favor the formation of the long-range periodic structure. Fe 2 O 3 tubular structures with average inner diameter about 500 nm and wall thickness about 20 nm were obtained. Conclusion: Electrospinning is powerful in structural control of inorganic oxide fibers. Figure.1 One-dimensional SiO 2 periodic structures (left) and Fe 2 O 3 hollow fibers (right). Key Words: Structural control; Application; Inorganic oxides; Electrospinning Acknowledgements: This research is supported by National Natural Science Foundation of China (No ) [1] Jianjun Li, et al. Manipulation and formation mechanism of silica one-dimensional periodic structures by roller electrospinning [J]. Langmuir, 2014, 30, [2] Jianjun Li, Ye Yuan, et al. Electrospun Fe 2 O 3 nanotubes and Fe 3 O 4 nanofibers by Citric Acid Sol-gel Method [J]. Journal of the American Ceramic Society, 2017, 100, [3] Ye Yuan, Jianjun Li, et al. Lightweight, flexible and strong core-shell non-woven fabrics covered by reduced graphene oxide for high-performance electromagnetic interference shielding, [J]. Carbon, Carbon, 2018, 130,

88 Assembling modification of biomass nanofibers Hongbing Deng 1, Xiaowen Shi 1, Yumin Du 1 1 Chitin Research and Development Center, School of Resource and Environmental Science, Wuhan University, Wuhan, Hubei, , China. The self-assembly and fine structure regulation of nanofibers in living organisms were studied, and surface-interface modification was carried out by electrospinning nanofibers in vitro to achieve the purpose of preparing biomimetic materials and high-value applications of biomass fibers. A series of studies have been carried out on fiber diameter distribution, deposition film thickness, hydrophilicity, mechanical properties, surface roughness, fiber gap, specific surface area, thermal properties, surface composition, functional groups and regulation of biological properties via electrostatic self-assembly, electrospray directional deposition, coating/suspension deposition, cell directional deposition, nanoparticle deposition and other means. The high-value applications of these works have been utilized in biomedical, environmental restoration and other fields. Figure: (a) LBL assembled protein double sustained release system for bone defect repair, (b) the microorganisms loaded sandwich-like nanofibrous mats with all-natural components for the removal of low concentration and high toxicity heavy metals in water[1]. Keywords: Biomass nanofibers, self-assembly, surface modification, biomimetic. Acknowledgements: This work was supported by the National Natural Science Foundation of China (No & ), partially supported by the Natural Science Foundation of Hubei Province of China (Team Project, No.2015CFA017) and the Fundamental Research Funds for the Central Universities of China (No kf0175). Reference [1] Yang W, Xiaodan Q, Shiyi C, et al. Adsorption of natural composite sandwich-like nanofibrous mats for heavy metals in aquatic environment[j]. Journal of Colloid and Interface Science, 2019, 539:

89 A Lotus Effect-Inspired Flexible and Breathable Membrane with Hierarchical Electrospinning Micro/nanofibers and ZnO Nanowires Rouxi Chen 1 2 3, Yuqin Wan 3, Weiwei Wu 6, Cao Yang 1, Ji-Huan He* 5, Jianhua Cheng* 1 2, Reinhard Jetter 4, Fank K Ko 3, Yuancai Chen 1 1 College of Environment and Energy, South China University of Technology, Guangzhou, China 2 South China Institute of Collaborative Innovation, Dongguan, China 3 Department of Material Engineering, University of British Colombia, Vancouver, Canada 4 Departments of Botany and Chemistry, University of British Colombia, Vancouver, Canada 5 National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, China 6 School of Advanced Materials and Nanotechnology, Xidian University, Shaanxi, , P.R. China. Hierarchical structures such as the leaf of lotus are promising models for self-cleaning surfaces. A biomimetic structure that contains PVDF microfibers (ZnO nanowires covered with oleic acid) was prepared here to illustrate the biomimetic lotus effect concept. This was prepared via electrospinning, hydrothermal synthesis, and dip coating. The hierarchical structure and oleic acid coating was shown to contribute to super hydrophobicity with a water contact angle (WCA) greater than 150. The super hydrophobic flexible membrane not only exhibited water droplet bouncing and rolling behaviors, but also demonstrated promising selfcleaning properties, water resistance, and permeability of air and water vapor. These characteristics have far reaching implications in broadening the application of the selfcleaning textiles, waterproof breathable membrane, medical devices, and surgical plants such as artificial blood vessels. Keywords: Lotus Effect, Bionics Design, Electrospinning, ZnO Nanowires, Selfcleaning Acknowledgement :This work was supported by China Scholarship Council (CSC), AFML (Advanced Fiber Material Lab) of UBC, China Postdoctoral Science Foundation Grant (2018M630949), The Central University Scientific Research Project (Grant No. 2017BQ051), Natural Science Foundation of Guangdong Province China (Grant No.2018A ), Dongguan Social Science and Technology Development Project (Grant No ). [1] Gao, Xuefeng, and Lei Jiang. "Biophysics: water-repellent legs of water striders." Nature (2004): [2] Feng, Lin, et al. "Super hydrophobic surfaces: from natural to artificial." Advanced materials (2002):

90 3.3 Nanofiber for sensors 89

91 Wearable self-powered sensor for vital sign monitoring and finger tap communication Xiao-Xiong Wang 1, Hui-Jing Qiu 1, Wei-Zhi Song 1, Long Yun-Ze 1 Collaborative Innovation Center for Nanomaterials and Devices, College of Physics, Qingdao University, Qingdao , China. and Triboelectric nanogenerators (TENGs) have attracted much attention due to the high output, low cost, and environmentally friendly nature. However, wearable devices still have certain hardness due to the choice of metal electrode, which has no gas permeability, and affects the wearing comfort. In addition, the electrode does not adhere firmly to the friction material, which also affects the electric performance. We report a TENG base on ordinary fabrics with polymerizes polyaniline (PANI) as electrodes, and uses polycaprolactone (PCL) to make the fabric and friction material fit well. The TENG have excellent softness and certain gas permeability, improving the comfort of the wearable smart health monitoring. The output electrical of TENG can arrive 200 μa and 1000 V under a frequency of 2.5 Hz. It can drive about 1000 LEDs and continuously supply power to electronic production. This truly wearable generator can provide a good information interface for critically ill patients. On the one hand, it can monitor the patient's breathing state in real time and give an alarm when the breathing stops. On the other hand, patients with language communication difficulty can also tap the finger to send messages by using Morse code. More importantly, we have experimentally proven that this self-powered sensor can still work normally with additional contact resistance, which will guarantee the long-term reliable operation of this device in a flexible environment. Key Words: Calibration free; Wearable; Triboelectric nanogenerator; Electrospinning; Energy harvesting. [1] Qiu H J, Song W Z, Wang X X, et al. A calibration-free self-powered sensor for vital sign monitoring and finger tap communication based on wearable triboelectric nanogenerator [J]. Nano Energy, 2019, 58: [2] Wang X X, Song W Z, You M H, et al. Bionic single-electrode electronic skin unit based on piezoelectric nanogenerator [J]. ACS Nano, 2018, 12: [3] You M H, Wang X X, Yan X, et al. A self-powered flexible hybrid piezoelectric-pyroelectric nanogenerator based on non-woven nanofiber membranes [J]. Journal of Materials Chemistry A, 2018, 6:

92 Plasma-assisted preparation of flexible SERS substrate Lu Jia 1, Lu Bai 2, and Zhicheng Liu 1 1 School of Materials Science and Engineering, Ocean University of China, Qingdao, , China. 2 School of Chemistry and Chemical Engineering, Qingdao University, Qingdao, , China.. Surface-enhanced Raman scattering (SERS), which serves as a sensitive detection technique, has attracted increasing attention in the fields of analytical science, surface science and material science. 1 Electrospun nanofiber with high porosity, large surface area and good flexibility is promising in incorporating noble metal nanoparticles for the preparation of high-performance SERS substrate. It remains a challenge to obtain such flexible SERS substrates using simple, green and facile methods. Here, we show that not only the preformed nanoparticles could be assembled on the plasma-modified electrospun nanofibers through electrostatic interaction, but also nanoparticles with different sizes could be in-situ generated on the plasma-treated metal-salt incorporated nanofibers (Fig. 1). 2,3 The obtained flexible SERS substrates exhibited excellent SERS activity and reproducibility. Fig. 1 Schematic representation of the plasma-assisted in-situ fabrication process of SERS substrate. Key Words: SERS, Plasma, Nanofiber, Nanoparticle Acknowledgements: National Natural Science Foundation of China, Grant and [1] Graham D, Moskovits M, Tian Z. SERS facts, Figures and the Future [J]. Chemical Society Reviews, 2017, 46: [2] Liu Z, Jia L, Yan Z, et al. Plasma-treated Electrospun Nanofibers as a Template for the Electrostatic Assembly of Silver Nanoparticles [J]. New Journal of Chemistry, 2018, 42: [3] Bai L, Jia L, Yan Z, et al. Plasma-assisted Fabrication of Nanoparticle-decorated Electrospun Nanofibers [J]. Journal of the Taiwan Institute of Chemical Engineers, 2018, 82:

93 Chemically Functionalized Single Strip Nanofiber Yarn Colorimetric Sensor Platform: Ultrasensitive Detection of Hydrogen Sulfide toward Halitosis Diagnosis Dong-Ha Kim 1, Jun-Hwe Cha 2, Jin-Gook Bae 1, Chanhoon Kim 1, Il-Doo Kim 1 1 Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea 2 Department of Electrical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea The ultrasensitive colorimetric gas sensor with fast response, high selectivity, and low detection limit is highly demanded but challenging to realize. The colorimetric gas sensor is a promising disease diagnosis platform owing to its simplicity and rapid detection properties [1 2]; lead acetates are wellknown colorimetric indicators to detect hydrogen sulfide (H 2 S) which is a biomarker of halitosis. Since halitosis patients contain as low as 1 ppm H 2 S in their exhaled breath, the detection limit (5 10 ppm) of conventional lead acetates-based colorimetric sensors should be greatly enhanced [3]. To address these issues, we propose the nanofiber yarn-based colorimetric sensor on which ionic liquids as effective H 2 S adsorbents and lead acetates as colorimetric dyes are co-functionalized (Figure 1). The high-density aligned nanofiber yarn is a highly promising platform not only to enhance the sensitivity but also to endow with portability and easy-handling for on-site detection. Noticeably, our sensors exhibited distinct color change even upon exposure to 1 ppm H 2 S for 10 s under highly humid condition (95% RH) with excellent selectivity. The sensors were further utilized for simulated halitosis breath tests, demonstrating the feasibility for reliable detection of the breath biomarker. We further demonstrated the smart-cloth type disease diagnosis sensor by integration on a textile. Figure 1. (a) Schematic illustration of the nanofiber yarn fabrication method using yarn-spinning, (b) scanning electron microscopy and transmission electron microscopy images of Pb(Ac) 2 dyes and ionic liquids co-sensitized nanofiber yarn, (c) schematic illustration of the nanofiber yarn colorimetric sensor before and after exposure to H 2 S gas, and (d) stitching pattern of the letter H 2 S sewed sensor before and after exposure to H 2 S. Key Words: Nanofiber yarn, colorimetric sensor, hydrogen sulfide, halitosis [1] J. R. Askim, M. Mahmoudi, K. S. Suslick, Optical sensor arrays for chemical sensing: the optoelectronic nose, Chem. Soc. Rev., Vol. 29, pp , [2] N. A. Rakow, K. S. Suslick, A colorimetric sensor array for odour visualization, Nat., Vol. 406, pp. 710, [3] M. Nakhleh, M. Quatredeniers, H. Haick, Detectio of halitosis in breath: Between the past, present, and future, Oral Dis., Vol. 24, pp. 685,

94 In-situ growht of WO 3 nanorods on porous graphene-tunicate composite fiber for sensitive chemiresistor Ji-Soo Jang, and Il-Doo Kim* 11 Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea Graphene oxide liquid crystal (GOLC) behavior is very intriguing and powerful phenomenon, especially for simply achieving graphene-based fibers, which have ordered graphene alignments in fiber. Taking advantages of graphene based fiber such as high mechanical strength, electrical conductivity, and supercapacitive behavior, various applications such as energy storage, photovoltaic cell, and chemical sensing have been explosively exploited. Although graphene based fiber have opened up great opportunities for various researches, high graphene density in graphene based fiber is disadvantageous to develop the porous fiber with high meso (2 50 nm) porosity; High porosity is essential for increased surface area and fast gas diffusion and penetration, leading to enhanced detection of toxic chemicals using graphene based fiber. Unfortunately, graphene based fiber is still challenging to detect the ppm level of toxic gas molecules such as nitrogen dioxide (NO 2 ) because of their poor porosity and low gas reactivity. Therefore, the suggestion of novel platform for the creation of pores on graphene based fiber is significantly desired. In this work, we propose a facile synthetic route for providing high density of pores in graphene based fiber by employing tunicate cellulose nanofiber (TCNF) engineering. For the first time, by using the liquid crystal (LC) behavior of graphene oxide (GO)-TCNF composite, we successfully develop the ultra-porous GO fibers due to the random distribution of TCNF in GO fiber. Furthermore, by using the super-hydrophilicity of TCNF, TCNF in GO fiber is also used as seed layer for growth of WO 3 nanorods (NRs), leading to formation of porous WO 3 NRs-GO thorn-bush like composite single fiber. Due to its high porosity and heterogeneous junction effect (WO 3 NRs-GO), porous WO 3 NRs-GO showed reversible NO 2 detection capability even at 1 ppm level of NO 2 chemicals. Key Words: porous graphene fiber, liquid crystal, tunicate, hierarchical structure, gas sensor 93

95 High-performance acetone gas sensor based on Co 3 O 4 /SnO 2 hollow nanotubes via an electrospinning route Yoon Hwa Kim 1, Min-Hyeok Kim 2, Ji-Soo Jang 2, and Il-Doo Kim 1,2 1 Wearable Platform Materials Technology Center and 2 Department of Materials Science and Engineering, Korea Advanced Institute of Science Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea. Accurate detection of exhaled breath gas molecules enables early diagnosis of specific diseases because specific volatile organic compounds (VOCs) or volatile sulfur compounds (VSCs) gases in exhaled breath act as breath markers for specific diseases.[1] For breath gas monitoring, the detector should be highly sensitive to breath biomarkers down to sub-parts per million (ppm) or even low parts per billion and be selective to the biomarkers in highly humid environment (typically 90% relative humidity).[2] Semiconducting metal oxides based gas sensors have attracted much attention for handheld portable medical diagnostic detectors due to their advantages such as easy miniaturization, easy operation, and cost effectiveness. In this study, porous Co 3 O 4 /SnO 2 hollow nanotubes (NTs) were prepared via electrospinning technique combined with galvanic replacement reaction (GRR) for VOCs gas detection. The designed sensing layers of Co 3 O 4 /SnO 2 hollow NTs, which are obtained by GRR, exhibited remarkably enhanced gas response, compared with that of Co 3 O 4 nanofiber at 5 ppm of acetone molecule as well as superior cross-selectivity against other interfering gases such as C 2 H 5 OH, CH 3 SH, H 2 S, C 7 H 8, C 5 H 12, NH 3, and CO. These results offer great potential for applications in robust detection exhaled breath biomarkers. Figure. Gas response (R air /R gas ) of various heterogeneous SMOs based sensors toward acetone, as reported in the recent literature. Key Words: Acetone sensor, metal oxides gas sensor, hollow nanotube structure, galvanic replacement reaction Acknowledgements: This work supported by Wearable Platform Materials Technology Center (WMC) funded by National Research Foundation of Korea (NRF) Grant by the Ministry of Science, ICT and Future Planning (NRF- 2016R1A5A ). [1] Peng G, Tisch U, Adams O, et al. Diagnosing lung cancer in exhaled breath using gold nanoparticles [J]. Nature Nanotechnology, 2009, 4: [2] Jang J.-S, Kim S.-J, Choi S.-J, et al. Thin-walled SnO 2 nanotubes functionalized with Pt and Au catalysts via the protein templating route and their selective detection of acetone and hydrogen sulfide molecules [J]. Nanoscale, 2015, 7(39):

96 Conductive Acid Doped Polyaniline Electrospun Nanofibres Made From Common Solvents Using a Facile Dissolution Method Maryanne E Spiers 1, Daniel S Eldridge 1, Peter Kingshott 1, David J Nielsen 2, Karl D Pavey 2, Yen B Truong 3 and Gregory C Rutledge 4 1 Department of Chemistry and Biochemistry, Faculty of Science, Engineering and Technology, Swinburne University of Technology, John Street, Hawthorn, Victoria, 3211, Australia. 2 Defence Science and Technology Group (DST Group), 506 Lorimer Street, Fishermans Bend, Victoria, 3207, Australia. 3 Manufacting Unit, Commonwealth Science and Industry Research Organization (CSIRO), Research Way, Clayton, Victoria, 3168, Australia. 4 Department of Chemical Engineering, Massachusetts Institute of Technology (MIT), 77 Massachusetts Avenue, Cambridge, MA, 02139, USA. Abstract A novel dissolution method that allows for the total solvation of high concentration, high molecular weight polyaniline (PANi) doped with (+)-camphor-10-sulfonic acid (HCSA) is reported. Solutions of wt% 65,000 MW polyaniline in N,N-dimethylformamide are achievable using a simple one-pot method. Doped polyaniline solutions in common organic solvents can now be processed into nanofibres (average fibre diameter: 460 nm) using a convenient single-nozzle electrospinning technique. The electrospinning of PANi-HCSA into nanofibrous membranes of high surface area is expected to complement its known chemiresistive properties for gas sensing applications. Figure 1: The morphology of 99.7% PANi-HCSA with 0.3% PEO nanofibrous non-woven mats, as observed via SEM imaging Key words: conductive polymers, polyaniline, single-nozzle electrospinning, dissolution [1] MacDiarmid, AG, Jones, WE, et al. Electrostatically-generated Nanofibres of Electronic Polymers [J]. Synthetic Metals, 2001, 119(1): [2] Yang, DL, Zuccarello, G, et al. Physical Stabilization or Chemical Degradation of Concentrated Solutions of Polyaniline Emeraldine Base Containing Secondary Amine Additives [J]. Macromolecules, 2002, 35(13): [3] Zhang, Y, Rutledge, GC. Electrical Conductivity of Electrospun Polyaniline and Polyaniline Blend Fibres and Mats [J]. Macromolecules, 2012, 45(10):

97 Electrospun ZnO Microbelts Based Acetylene Sensor Peresi Majura Bulemo a,b and Il-Doo Kim a,c a Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea. b Department of Mechanical and Industrial Engineering, University of Dar es Salaam, P. O. Box 35131, Dar es Salaam, Tanzania. c Advanced Nanosensor Research Center, KI Nanocentury, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea. Gas-accessible surfaces endow semiconducting metal oxides (SMOs) based gas sensing materials with enhanced surface reactions between adsorbed oxygen species and analyte gas molecules, resulting in high sensor s sensitivity. Thin SMO-based microbelts possess such desirable features. On the other hand, the need for low power consumption has necessitated a consideration for optimal design of nanostructures catering for low resistivity and low operating temperature. Herein, we combined the two goals via electrospinning of gallium doped zinc oxide microbelts (Ga ZnO MBLs) and employed them for acetylene sensing. Briefly, saponin, the templating polymer (polyvinylpyrrolidone), and the metal precursors were dissolved in an alcohol-water cosolvent followed by electrospinning and high temperature calcination. During electrospinning, alcohol evaporated more quickly, forming a thin dry skin on the surface of the electrospun fiber, whereas saponin interacted strongly with water in the interior. Consequently, the fiber collapsed into the belt morphology. We observed that doping with Ga not only reduced the resistivity of ZnO but also provided smaller crystallites, a bonus feature for enhanced response (defined as R a /R g, where R a and R g are resistances in air and acetylene, respectively) to acetylene. Note that the use of acetylene is limited by its highly combustible and explosive nature, and a wide range of flammability limits in air. Thus, highly sensitive and selective acetylene sensor can widen its use in a number of industrial applications. During gas sensing tests, we observed that undoped ZnO MBLs exhibited extremely high base resistance beyond the limit of our sensing instrument, whereas the Ga-doped ZnO MBLs (12 mol% Ga) showed appreciable response (R a /R g = 20) toward 20 ppm acetylene at 400 C (Figure 1). As observed in Figure 1, functionalization of Ga-ZnO MBLs with polyol-synthesized platinum nanoparticles (Pt NPs) provided enhanced response toward acetylene (R a /R g = 33.5 at 20 ppm), and a good selectivity against CO, CH 4, and HCHO. The enhanced acetylene sensing of Pt-loaded Ga-ZnO MBLs and Ga-ZnO MBLs compared to ZnO MBLs is attributed to reduced resistivity by Ga-doping and the catalytic activity of the Pt NPs. Figure 1. (a) Morphology of Pt-loaded Ga-ZnO MBLs calcined at 680 C for 2 h and (b) acetylene sensing performance of pristine Ga-ZnO MBLs and Pt-loaded Ga-ZnO MBLs at 400 C. Key Words: electrospinning, ZnO microbelts, gas sensor, doping [1] Tang A, Mei Z, Hou Y, et al. Ga Zn -V Zn Acceptor Complex Defect in Ga-doped ZnO [J]. Sci. China-Phys. Mech. Astron, 2018, 61(7): [2] Tamaekong N, Liewhiran C, Wisitsoraat A, et al. Acetylene Sensor Based on Pt/ZnO Thick Films as Prepared by Flame Spray Pyrolysis [J]. Sens. Actuators B, 2011, 152(2):

98 Coaxial fibers with chiral-nematic liquid crystal core for gas sensing Lukas Pschyklenk 1, Katrin Schelski 1, Thorsten Wagner 2, Peter Kaul 1 1 University of Applied Sciences Bonn-Rhein-Sieg, Institute of Safety and Security Research, Von- Liebig-Str. 20, Rheinbach, Germany. 2 Paderborn University, Department of Chemistry, Warburger Straße 100, Paderborn, Germany. The rapid and reliable detection of harmful substances is of great interest for civil safety and security research. Whereas the market is dominated by power supply dependent equipment, doped liquid crystal (LC) based detectors are a promising alternative unattached to current [1]. The chiralnematic phase is capable of forming one-dimensional photonic crystals showing iridescent coloration, i.e. color appearance and hence reflection spectra depend on the helical pitch of the LC and the viewing angle. A chemical gas reaction induced by a reactive dopant can change the pitch causing a shift in the maximum of the reflection spectrum, which can be utilized for sensing. However, the LCs are sensitive to environmental and mechanical influences which prevents their direct application. To overcome this issues, we present a method to encapsulate the LCs into fibers by coaxial electrospinning (Fig. 1). A polymer shell protects a LC core against environmental and mechanical influences [2] and in addition affects the selectivity due to the gas permeability of the polymer. In the presented case polyvinylpyrrolidone (PVP) is used as shell material. The core is composed of E7 and E8, respectively, each doped with various reactive chiral substances. Electrospinning was accomplished utilizing a custom-built ring-shaped counter electrode resulting in free hanging fibermats. The continuously filled and smooth fibers have outer diameters up to 10 µm and core diameters up to 5 µm. Main advantages of these dimensions are the simple accessibility of structural parameters by light microscopy as well as a decrease of light scattering. The sensitivity of the non-woven mats towards an exemplary analyte (CO 2 ) is determined by UV/VIS-spectroscopy to 90 nm peak shift for 100 % CO 2 in N 2. Reaction and regeneration of the fibers with CO 2 can even be observed by nakedeye (t 90 ~ 15 s). The performed experiments show that encapsulation by coaxial electrospinning allows to synthesize stable and sensitive LC-based gas detectors. Fig. 1: Light microscopic picture of a single coaxial fiber with LC core appearing red and polymer shell in blue (left),the schematic fiber cross-section (middle) and UV/VIS spectra of the encapsulated LC during the reaction (right) Key Words: Coaxial electrospinning, gas sensing, chiral-nematic, liquid crystal Acknowledgements: This work is part of the BMBF-Project OptoSpin. The authors acknowledge the financial support by the Federal Ministry of Education and Research of Germany. [1] Mulder DJ, Schenning, A. P. H. J., Bastiaansen, C. W. M. Chiral-nematic liquid crystals as one dimensional photonic materials in optical sensors. J. Mater. Chem. C 2014;2(33): [2] Kim DK, Hwang M, Lagerwall, Jan P. F. Liquid crystal functionalization of electrospun polymer fibers. J. Polym. Sci. Part B: Polym. Phys. 2013;51(11):

99 A superhydrophilic, underwater superoleophobic and highly stretchable humidity and chemical vapor sensor based on the carbon nanotube decorated nanofiber composite for human breath detection Jiefeng Gao, Xuewu Huang, Bei Li, Ling Wang, and Huaiguo Xue School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, , China Humidity and chemical vapor sensors have promising applications in the field of environment protection, human healthcare, etc.[1] It is still changeling to develop sensor materials that can be served as both humidity and chemical vapor sensors with a high sensitivity while low detection limit, excellent stretchability, repeatability and reliability.[2] In this study, flexible, stretchable and conductive nanofiber composite (CNC) with superhydrophilicity and underwater superoleophobicity is prepared by acidified carbon nanotubes (ACNTs) decoration onto the thermoplastic polyurethane (PU) nanofiber surface. ACNT introduction increases both the Young s modulus and tensile strength and almost maintains the superelasticity of the PU nanofibrous membrane. The as-obtained CNC could be used to detect both moisture and chemical vapors. When used as the humidity sensor, ACNTs can absorb surrounding water molecules and thus increase their resistance. On the other hand, the PU can be swollen by different chemical vapors, which can, to different extent, damage the conductive network inside the composite and cause the increase of the composite resistance. The CNC can be integrated with a mask for real-time detection of human respiration. The CNC based chemical vapor sensor possesses low detection limit, quick response, good selectivity and excellent recyclability (even in a high humid environment), and has potential applications in monitoring biomarker gases from human breath. Key Words: Underwater superoleophobicity, Electrically conductive, Nanofiber composite, Humidity sensor, Chemical vapor sensor [1] Borini S, White R, Wei D, et al. Ultrafast Graphene Oxide Humidity Sensors [J]. ACS Nano, 2013, 7(12): [2] Li T, Li L H, Sun H W, et al. Porous Ionic Membrane Based Flexible Humidity Sensor and its Multifunctional Applications [J]. Adv. Sci., 2017, 4(5):

100 3.4 Characterization of nanofibrous materials 99

101 High performance electrospun polyimide nanofibers and their application as reinforcements Shaohua Jiang 1, Haoqing Hou 2, Seema Agarwal 3, and Andreas Greiner 3 1 College of Materials Science and Engineering, Nanjing Forestry University, Nanjing , China. 2 Department of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang , China. 3 Macromolecular Chemistry II, University of Bayreuth, Gebäude NWII, Universität Bayreuth, Universitätsstrasse 30, Bayreuth 95440, Germany. Electrospun polyimide nanofibers possesses excellent mechanical properties, thermal stabilities, and chemical resistance. They have been broadly applied in many fields, such as reinforcements, filtration, battery separator, and so on. Our group devoted lots of efforts on the mechanical properties of aligned polyimide nanofibers (ANF-PI) and single polyimide nanofiber (SNF-PI). The ANF-PI showed high tensile strength of >1.0 GPa, and high modulus of > 10.0 GPa [1, 2]. The SNF-PI even exhibited superior tensile strength of 2.87 GPa, and modulus of 130 GPa [3]. These excellent mechanical properties could be attributed to the highly molecular orientation along the fiber axis, which have been proved by polarized FT-IR spectroscopy and polarized Raman spectroscopy [3, 4]. Therefore, these PI electrospun nanofibers could be good candidates as reinforcements [5]. They are used to reinforce epoxy, and the composites presented an improvement of 679% and 1187% of tensile strength and toughness, as comparing to those of pure epoxy [6]. In addition, the PI electrospun nanofibers could be processed into short nanofibers as reinforcements. In this case, 2 wt% addition of PI short nanofibers could achieve the best mechanical enhancement than PI films and other PI composite samples with wt% addition of as-prepared continuous and long PI nanofibers as reinforcements [7]. Figure 1. Single polyimide electrospun fiber to hold a weight and its use as reinforcement. Key Words: Polyimide nanofiber; molecular orientation; mechanical property; composite [1] Chen S, Hu P, Greiner A, et al. Electrospun nanofiber belts made from high performance copolyimide [J]. Nanotechnology, 2008, 19(1): [2] He Y, Han D, Chen J, et al. Highly strong and highly tough electrospun polyimide/polyimide composite nanofibers from binary blend of polyamic acids[j]. RSC Adv., 2014, 4(104): [3] Jiang S, Han D, Huang C, et al. Temperature-induced molecular orientation and mechanical properties of single electrospun polyimide nanofiber [J]. Mater. Lett., 2018, 216: [4] Yang H, Jiang S, Fang H, et al. Molecular orientation in aligned electrospun polyimide nanofibers by polarized FT-IR spectroscopy [J]. Spectrochim. Acta A, 2018, 200: [5] Jiang S, Chen Y, Duan G, et al. Electrospun nanofiber reinforced composites: A review [J]. Polym. Chem., 2018, 9: [6] Chen Y, Sui L, Fang H, et al. Superior mechanical enhancement of epoxy composites reinforced by polyimide nanofibers via a vacuum-assisted hot-pressing [J]. Compos. Sci. Technol., 2019, 174: [7] Jiang S, Duan G, Schöbel J, et al. Short electrospun polymeric nanofibers reinforced polyimide nanocomposites [J]. Compos. Sci. Technol., 2013, 88:

102 Predicting the elastic properties of electrospun nanofibrous membranes using numerical simulation Muhamad Shafiq Sukiman 1, Andri Andriyana 1,2 and Bee Chin Ang 1,3 1 Centre of Advanced Materials, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia. 2 Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia. 3 Department of Chemical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia. In the context of industrial applications, elastic properties of electrospun fibers are among critical characteristics that control their in-service performance. For polymeric electrospun fibrous structures, it is known that their elastic properties are strongly affected by a number of factors including fiber material (e.g. polymer type, molecular weight, crystallinity), morphology (e.g. fiber diameter and orientation, presence of beads) and environmental condition in which the fibers are produced. Furthermore, the morphology of fibers is dictated by the electrospinning parameters such as feed rate, collector distance and voltage. At the moment, the optimization of elastic properties of electrospun fibrous structures is typically conducted experimentally through trial and error, which could be costly and time-consumming. If a fast and robust alternative solution for the evaluation of elastic properties could be developed, fiber industries would benefit a potentially significant amount of cost saving during the design phase of fibrous structures for specific applications. The present work focuses on the evaluation of elastic properties of randomly-oriented electrospun nanofibrous membranes using numerical technique. The proposed technique is based on linear elastic homogenization of pixel-based specimens (images). More precisely, SEM images taken from fibrous membrane samples are treated into binary images and meshed using multiphase element technique composed of quadratic square finite elements. The finite element calculations are subsequently carried out by applying loads under periodic boundary conditions on the meshed images. Two material parameters are needed for calculation: elastic modulus of single fiber and membrane porosity. As a starting point, two types of polymers are considered: PVDF and PU. Results show that the proposed numerical model provides a good estimation of membrane elastic modulus and Poisson s ratio. Figure 3. Superposition of finite element mesh onto SEM image Key Words: Elastic properties, finite element, SEM image, fiber Acknowledgements: The authors greatly appreciate the financial support from University of Malaya through grants FG010-17AFR, RP041A- 17AET and RP041C-17AET. [1] Dannee W, Verron E, Andriyana A, Ang B C. Constitutive modeling of randomly oriented electrospun nanofibrous membranes. Continuum Mechanics and Thermodynamics [2] Sukiman M S, Kanit T, N'Guyen F, et al. Effective thermal and mechanical properties of randomly oriented short and long fiber composites. Mechanics of Materials. 107,

103 In situ embedding alumina to improve the mechanical properties of YAG nanofibrous membrane Juan Jiang 1, Na Ni 1, 2, *, Xiaofeng Zhao 1, *, Ping Xiao 1 1 School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai , China; 2 School of Mechanical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai , China Yttrium-aluminum garnet (YAG) material owns excellent performance, such as high strength, high temperature stability, low thermal conductivity, radiation resistance and oxidation resistance. In addition, YAG material has emerged as the most widely produced laser gain host and has enjoyed recent popularity as a substrate material for optical components. Hence, YAG nanofibrous membrane is a critical demand for high temperature and laser applications [1,2]. However, the intrinsic brittleness and low mechanical strength limit its applications. Under the above consideration, this study manufactured YAG and YAG-Al 2 O 3 nanofibrous membranes. The aim of Al 2 O 3 is to improve the mechanical performance of YAG nanofibrous membrane through second phase reinforcement. In this work, Yttrium aluminum garnet (YAG) nanofibrous membrane and YAG- alumina nanofibrous membrane composed of randomly oriented nanofibers with an average diameter of 350 ± 50 nm were fabricated by a combination of sol-gel and electrospinning method, and then sintered in air. The effects of alumina content on the microstructure and mechanical performance of YAG membranes were investigated. The flexible mechanism was also discussed. At 900 C, The grain size and porosity of the fibers decreased with the increase of alumina addition. The nanofibrous membranes present a brittle-to-flexible transformation as the alumina reaches to 30 vol.% YAG. The addition of Al2O3 also increases the tensile strength. These phenomena are due to the second phase alumina, which is amorphous at 900 C, restraining the YAG grain growth and inducing a much denser morphology. Key Words: YAG nanofibrous membrane, alumina addition, mechanical performance, flexible mechanism Fig. 1 A brittle-to-flexible transition of YAG and YAG-Al2O3 nanofibrous membranes. SEM images of (a-d) YAG-Al2O3 membranes with alumina contents from 0 to 30 mol%, respectively. [1] Li D, McCann J T, Xia Y, et al. Electrospinning: a simple and versatile technique for producing ceramic nanofibers and nanotubes [J]. J. Am. Ceram. Soc., 2006, 89: [2] Kim H J, Fair G E, Hart A M, et al. Development of polycrystalline yttrium aluminum garnet (YAG) fibers [J]. J. Eur. Ceram. Soc., 2015, 35:

104 3.5 Electrospin technical 103

105 Machine Processing of Electrospun Yarns into Knitted and Woven Structures Magnus Kruse 1, Thomas Schneiders 1, Mark Stude 1, Lukas Först 1, Stefan Jockenhoevel 2, Thomas Gries 1, Andreas Blaeser 1 1 Instiut fuer Textiltechnik der RWTH Aachen University, Otto-Blumenthal-Straße 1, Aachen, Germany. 2 Department of Biohybrid and Medical Textiles (BioTex) AME-Helmholtz Institute for Biomedical Engineering, Forckenbeckstr. 55, Aachen, Germany Introduction Electrospinning is used in different fields of applications mostly in form of nonwoven structures. The development of electrospun yarns enables the production of textile fabrics which combine the submicron dimension of e-spun filaments with 3D drapable textile fabrics. Hence, the aim of the study was the production of e-spun yarns and their implementation into a knitting and weaving process. Experimental Setup Solutions with three different polymer compositions (100:0, 90:10, 75:25 PLA:PEG) were spun into e-yarns. Therefore, the solutions were prepared with a polymer concentration of 6 wt% in CHCl 3. The e-yarns were produced on a custom-made electro-spinning machine using a funnel collector system. [1] The winder operated at different winding velocities between m/h. The rotational velocity of the funnel was varied between rpm. The trials were planned based on a factorial design. [2] Results and Discussion The yarns were analyzed regarding their morphology and stress-strain behavior. Depending on the process parameters winding velocity and funnel rotation the yarn diameter varied between µm, the fiber diameter between µm and the twist angle between The mechanical properties showed a tensile strength between cn/tex and a strain between %. In order to produce e-yarns which could be further processed in a machine knitting and weaving process, the spinning process had to be scaled up. Therefore, the parameters were adjusted to a winding velocity of 1 m/min and a funnel rotation of 2000 rpm. The yarn properties showed a tensile strength of 2.0 cn/tex and a strain of 253 %. The yarn diameter was 53.6 µm, the fiber diameter 3.7 µm and the twist angle The PLA/PEG-yarns were successfully processed on a knitting machine into a tubular structure and used as weft yarn on a narrow fabric needle loom. Conclusion Electrospun PLA/PEG yarns were successfully spun from different blend types. The yarns were characterized regarding their morphology and mechanical strength and showed decent mechanical properties. The upscaling from 0.4 m/min to 1 m/min of the yarn spinning process was also successful. The yarns produced in the up scaled spinning process were subsequently knitted into a tubular structure and used as a weft yarn. Key Words: PLA, PEG, yarn, weaving, knitting [1] Ali, U.; Zhou, Y.; Wang, X.; Lin, T.: Direct electrospinning of highly twisted, continuous nanofiber yarns, Journal of the Textile Institute, 2012, 103(1): [2] Kruse, M.; Greuel, M.; Kreimendahl, F.; Schneiders, T.; Bauer, B.; Gries, T.; Jockenhoevel, S.: Electro-spun PLA-PEG-yarns for Tissue Engineering Applications. Biomedizinische Technik/Biomedical engineering, 2018, 63(3):

106 The applications of un-spinnable fluids in creating nanostructures during the multiple-fluid electrospinning processes Deng-Guang Yu, Menglong Wang, Yaoyao Yang, Ke wang 1 School of Material Science and Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Yangpu District, Shanghai , P.R. China. The multiple-fluid electrospinning is more powerful than the traditional one-fluid blending process in two aspects. One is the potential treatment of un-spinnable working fluids, by which the great surface and huge porosity of nanofiber mat can be taken full advantages for the dispersed functional ingredients. The other is the new possibilities in creating novel and complex nanostructures. Fig. 1 The applications of un-spinnable fluids in preparing electrospun nanofibers. In this reports, three examples are given to exhibit how to incorporate the un-spinnable fluids in the coaxial, tr-axial and side-by-side electrospinning processes. The modified multiple-fluid electrospinning are demonstrated to be useful in generating new core-shell nanofibers [1], manipulating the shells thicknesses of core-shell nanostructures [2], and producing Janus nanofibers with high quality [3]. In a word, the applications of un-spinnable fluids in multiple-fluid electrospinning not only modify the working processes profoundly, but also provide many new possibilities for developing novel functional nanostructures. Key Words: Un-spinnable fluid, multi-fluid electrospinning, nanostructure Acknowledgements: The National Natural Science Foundation of China (No ) [1] Hai T, Wan X, Yu D G, Wang K, Yang Y Y and Liu Z P. Electrospun Lipid-Coated Medicated Nanocomposites for an Improved Drug Sustained-Release Profile [J]. Materials & Design, 2019, 162: [2] Liu X, Yang Y, Yu D G, Zhu M J, Zhao M and Williams G R. Tunable zero-order drug delivery systems created by modified triaxial electrospinning. Chemical Engineering Journal, 2019, 356: [3] Yu D G, Li J J, Zhang M and Williams G R. High-Quality Janus Nanofibers Prepared Using Three-fluid Electrospinning [J]. Chemical Communications, 2017, 53(33):

107 Preparation of Polypropylene Micro and Nanofibers by Electrostatic- Assisted Melt Blown and Their Application Jie Zheng*, Yi Pu, Fuxing Chen, Xin Ning* Industrial Research Institute of Nonwovens & Technical Textiles, College of Textiles &Clothing, Qingdao University, Qingdao , China. In this paper, a novel electrostatic-assisted melt blown process was reported to produce polypropylene (PP) microfibers with a diameter as fine as 600 nm. The morphology, web structure, pore size distribution, filtration efficiency, and the stress and strain behavior of the PP nonwoven fabric thus prepared were characterized. By introducing an electrostatic field into the conventional melt-blown apparatus, the average diameter of the melt-blown fibers was reduced from 1.69 to 0.96 um with the experimental setup, and the distribution of fiber diameters was narrower, which resulted in a filter medium with smaller average pore size and improved filtration efficiency. The polymer microfibers prepared by this electrostatic-assisted melt blown method may be adapted in a continuous melt blown process for the production of filtration media used in air filters, dust masks, and so on. Figure 1 (a) The schematic illustration of the electrostatic-assisted melt-blown system setup (b) SEM graphs (c) Diameter distribution (d) Filtration efficiency. Key Words: Electrospinning; Melt Blown; Non-Woven Fabric Acknowledgements: This study was funded by the National Natural Science Foundation of China ( and ), Natural Science Foundation of Shandong Province grant number ZR2018BB043, Postdoctoral Scientific Research Foundation of Qingdao grant number and [1] Chen H B, He W L, Qin Y X, et al. Melt Electro-Blowing Spinning for Preparation of Nanofibers [J]. Plastics, 2017, 46, [2] Luo C J, Stoyanov S D, Stride E, et al. Electrospinning versus Fibre Production Methods: From Specifics to Technological Convergence [J]. Chem. Soc. Rev., 2012, 41, [3] Weiss D, Skrybec D, Misslitz H, et al. Tailoring Supramolecular Nanofibers for Air Filtration Applications [J]. ACS Appl. Mater. Interfaces, 2016, 8,

108 Fabrication of microfluidic channels based on Near-field Electrospinning with double-nozzle Jiarong Zhang 1, Han Wang 1, Guojie Xu 1, Zhifeng Wang 2, Honghui Yao 1, and Shengyong Yan 1 1 Department of Mechanical and Electrical Engineering, State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment, Guangdong University of Technology, Guangzhou , China. 2 School of Electromechanical Engineering, Foshan University, Foshan , China; Microfluidic channels has been widely applied in biomedicine and microelectronics. However, the fabrication methods of microfluidic channel devices, such as photolithography and three-dimensional printing, have the problems of high cost and complex process. Zeng [1] proposed a agile method to fabricates T-shape and cross-channel devices using Melt-electrospinning direct writing (MEDW) PCL fiber walls as templates. But fibers still can't reach a sub-micron scale stably because of the technological limitations of MEDW [2]. In order to improve the production efficiency and resolution of microfluidic channels, Near-field Electrospinning direct-writing technology with synergetic doublenozzle is proposed as Figure shown. It depends on the following steps:(1) Direct Writing of PEO Nanofiber Layer by synergetic double-nozzle. (2)Reservoir fabrication with copper tape and PDMS packaging. (3) Microfluidics plate from the PEO layer. (4) PDMS bonding by hot briquetting. Then, the experimental result compared with COMSOL simulation were discussed, and the interference between double-nozzle does not affect the accuracy of direct writing. Moreover, 8% PEO mixed by 1:1 anhydrous ethanol and deionized water is more suitable to fabricate high-quality fiber walls. Finally, Parallel array and grid array microchannel devices were made to illustrate the applicability and potential of this method in the fabrication of microfluidic devices, which width and height can reach 931nm and 2.41um. Key Words: Microfluidic channels, Double-nozzle, Near-field Electrospinning, PEO layer Acknowledgements: This work was financially supported by Project of Key laboratory construction projects in Guangdong (No. 2017B ), National Natural Science Foundation of China (No ), Project of Science and Technology of Guangdong Province (No. 2017B ). [1]. Zeng, J., et al., Fabrication of microfluidic channels based on melt-electrospinning direct writing. MICROFLUIDICS AND NANOFLUIDICS, (232). [2].Hochleitner, G., et al., Melt electrospinning writing of defined scaffolds using polylactide-poly (ethylene glycol) blends with 45S5 bioactive glass particles. MATERIALS LETTERS, : p

109 Polymer melt differential electrospinning: an eco-friendly way for nanofiber mass production Haoyi LI, Jing Tan, Hua Yan, Weimin Yang College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beisanhuan East Road, Chaoyang District, Beijing , China, Abstract: Many kinds of electrospinning methods have emerged and been well investigated in the past two decades in the pursuer of efficient nanofiber preparation, among which, melt electrospinning, as a non-solvent route, has draw great attention in recent years since its high yield and safety[1]. However, there was few work has been done on the mass production of nanofiber and yarn production by this polymer melt based method because of its high viscosity, complex heating system, and thick fiber[2]. On this basis, a melt differential electrospinning method without needles was proposed[3], by which a single nozzle with diameter of 26 mm, could generate more than 70 jets [3]and yield two orders of magnitude more than the capillary electrospinning did. A simple solution for yarn production was also introduced with narrow diameter distribution[4]. Larger scale production can be easily performed by modular designing and assembling. For example, Polypropylene nanofiber with diameter around 500nm and Polylactic Acid (PLA) nanofiber with diameter around 300nm[5] can be achieved by this method. Based on this principle, complete commercial techniques and equipments have been developed, and applications[6-8] of as-spun fibers in air filtration, oil spill recovery and water treatment, etc, are promising. Key Words: electrospinning, polymer melt, nanofiber, multiple jets, scaling-up Acknowledgements: This work was supported by National Natural Science Fund ( ) and National key research and development plan (2016YFB ) [1] Ding B, Wang X, Yu J. JianyElectrospinning: Nanofabrication and Applications[M]. William Andrew, [2] Brown T D, Dalton P D, Hutmacher D W. Melt electrospinning today: An opportune time for an emerging polymer process[j]. Progress in Polymer Science, 2016, 56: [3] Li H, Chen H, Zhong X, et al. Interjet distance in needleless melt differential electrospinning with umbellate nozzles[j]. Journal of Applied Polymer Science, 2014, 131(15). [4] Ma X, Zhang L, Tan J, et al. Continuous manufacturing of nanofiber yarn with the assistance of suction wind and rotating collection via needleless melt electrospinning[j]. Journal of Applied Polymer Science, 2017, 134(20). [5] Qin Y, Cheng L, Zhang Y, et al. Efficient preparation of poly (lactic acid) nanofibers by melt differential electrospinning with addition of acetyl tributyl citrate[j]. Journal of Applied Polymer Science, 2018, 135(31): [6] Li H, Li Y, Yang W, et al. Needleless Melt-Electrospinning of Biodegradable Poly(Lactic Acid) Ultrafine Fibers for the Removal of Oil from Water[J]. Polymers, 2017, 9(2):3. [7] Li X, Zhang Y, Li H, et al. Effect of oriented fiber membrane fabricated via needleless melt electrospinning on water filtration efficiency[j]. Desalination, 2014, 344(344): [8] Li H, Wu W, Bubakir M M, et al. Polypropylene fibers fabricated via a needleless meltelectrospinning device for marine oil spill cleanup[j]. Journal of Applied Polymer Science, 2014, 131(7):

110 Immunomodulated Electrospun Fibrous Scaffolds Via bfgf Camouflage for Pelvic Regeneration Menglu Qin 1, Xinliang Chen 1*,Wenguo Cui 2* 1 Department of gynecology, The International Peace Maternity & Child Health Hospital of Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, NO.910, Hengshan Road, Xuhui District, Shanghai , P. R. China. 2 Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai , P. R. China. Nanofibrous structures of electrospun fiber may more closely resemble the features of natural ECM because of which unique mechanical properties, higher rates of selective protein adsorption,and providing of anti-inflammatory microenvironment [1]. Roman et al. found biodegradable poly-l-lactic acid (PLLA) scaffolds approved by FDA might be a great tissue engineered repair material (TERM). However, the electrospun fiber implanted into tissues often induce an inflammatory reaction around the scar, also known as the foreign body response (FBR) after implantation [2]. In this study, we constructed the electrospun nanofibrous membranes which modified by bfgf have long-term safety, biodegradability and immune-regulation properties for tissue repair engineering. Such surface modification of PLLA fibers with bfgf was found to efficiently promote the biocompatibility without changing the morphology or mechanical properties of the materials. Additionally, bfgf modified PLLA fibers significantly promote the survival and proliferation of cells on the nano-materials compared to the unmodified PLLA. Importantly, bfgf-modified PLLA fibers were found to result in less inflammation, higher fibroblast adhesion, greater degree of organization of deposited collagen, and increased tensile strength compared to naked PLLA after 5 months of implantation. These data suggest that bfgf modified PLLA fibers can be used for biomedical applications that require the immune-regulation of pelvic regeneration, including the development of complex engineered tissues. Key Words: Pelvic organ prolapsed(pop), Transvaginal repair, Polylactic acid(plla), X-ray photoelectron spectroscopy(xps), Basic fibroblast growth factor(bfgf) Acknowledgements: National Natural Science Foundation of China General Program( ) [1] Dahlin RL, Kasper FK, Mikos AG. Polymeric nanofibers in tissue engineering. Tissue Eng Part B Rev. 2011;17(5): [2] Xiang Y, WG*, et al. Self-Nanoemulsifying Electrospun Fiber Enhancing Drug Permeation. ACS Applied Materials & Interfaces ; doi: /acsami.8b [3] Chen C, WG*, et al. Bioinspired Hydrogel Electrospun Fibers for Spinal Cord Regeneration. Adv Func Mater. 2019;9:

111 region Extension rate of electrospinning jet measured by light scattering Chi Wang 1, Yu Wang 1, and Takeji Hashimoto 2 1 Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan, ROC. 2 Kyoto University, Kyoto , Japan In this study, the diameter profile of the tapering straight jet is determined with a laser light-scattering technique. Afterwards, the jet extension rate ( ) is derived and used to compare with the solutionintrinsic rates, e.g., the terminal relaxation rate and the Rouse relaxation rate. The extension rate of the straight jet depends on position: it is highest near the cone apex (region I) and decays to a constant value in the major jet (region II) until approaching the jet end (region III), at which the extension rate abruptly drops to nearly zero, i.e., I > II >> III ~ 0. The jet diameter in region III is independent of solution concentration, and is scaled to the flow rate with an exponent of ~0.37. In regions I and II, the extension rate exceeds the relaxation rate of the solution, thereby yielding a high Weissenberg number. Hence, significant orientation or even stretching of the polymer chains is expected, which might eventually cause stress-induced phase separation in the spin line. (a) (b) apex I II III FIGURE 1. (a) Schematic of the light-scattering setup to obtain the equatorial intensity profile (azimuthal angle = 90 ) of the straight jet along the spinning line. The corresponding jet diameter d j is determined from the equatorial intensity profile as a function of distance z from the needle end z= 0. (b) High-speed camera image of the jet during electrospinning. The diameter of the straight jet end is denoted as d j,e. The dimensions of the Taylor cone and d j in region I are measured by the recorded optical image, whereas the jet diameters in regions II and III are derived from the light-scattering pattern. [J. Polym. Sci., Part B: Polym. Phys. 2018, 56, ] Key Words: light scattering, extension rate, relaxation rate, stress-induced phase separation Acknowledgements: The authors are grateful to the Ministry of Science and Technology, Taiwan, R.O.C. for the research grant (MOST E MY3, MOST E-210-MY3). 110

112 Constructing Three-Dimensional Cathodes with High Energy Density for Li/Na Ion Batteries by Electrospinning Ying Huang, and Wei Luo * Institute of New Energy for Vehicles, School of Materials Science and Engineering, Tongji University, Shanghai, , P.R. China. Electrospinning is a versatile method to construct a three-dimensional (3D) conductive network for carbon-based composites and synthesize nanosize electrode materials. In our work, by utilizing electrospinning technique, a metallic copper (Cu)/carbon composite with ~200 nm Cu nanoparticles uniformly anchored on interconnecting carbon nanofibers (CNFs) was fabricated. The as designed Cu/CNFs cathode delivered a reversible capacity of 635 mah/g with a high output voltage of 3.61 V and afforded a superior rate capability as well as a stable cycle performance in lithium ion battery. With Li 4 Ti 5 O 12 anode, a Cu/Li 4 Ti 5 O 12 full cell exhibited a high discharge capacity of 601 mah/g and an average output voltage of 2.0 V. In addition, we also fabricated a hierarchical metal-organic flexible cathode for high-energy sodium ion batteries using electrospinning method, in which cuprous tetracyanoquinodimethane (CuTCNQ) nanorods in-situ grown on the conductive carbon nanofibers, exhibited a high capacity of 252 mah/g at 0.1 C for sodium storage. Besides, highly reversible stability of 1200 cycles and specific energy of 762 Wh/kg were achieved. Our work demonstrated that electrospinning is an effective method in boosting the electrochemical performance of high energy density batteries. Figure 1. SEM images of (a, b) Cu/CNFs composite electrode and (c, d) CuTCNQ/CNFs composite electrode. Key Words: electrospinning, high energy density, lithium ion batteries, sodium ion batteries [1] Huang Y, Luo W, Huang Y. H, et al. Activate Metallic Copper as High-capacity Cathode for Lithium-ion Batteries via Nanocomposite Technology [J]. Nano Energy, 2018, 54: [2] Huang Y, Fang C, Huang Y. H, et al. In Situ-Formed Hierarchical Metal Organic Flexible Cathode for High-Energy Sodium-Ion Batteries [J]. ChemSusChem, 2017, 10:

113 Investigation of process parameters with a modified corona electrospinning Haijun He 1, Yahya Kara 1, Kolos Molnar 1,2 1 Department of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary. 2 MTA BME Research Group for Composite Science and Technology, Műegyetem rkp. 3., H-1111 Budapest, Hungary Needleless high-speed electrospinning methods seem to be currently the most feasible techniques for large scale polymer nanofiber production. A popular type of needleless methods is slit-electrospinning [1], in which the polymer solution is pumped through a narrow and long slit, from which the jets are initiated. In our study, we propose a novel electrospinning method [2], where the jet formation is aided by shearing the solution in situ. At our new setup the free surface of the solution is small, minimizing solvent evaporation. Using a general polymer solution the viscosity decreases by shearing, i.e. the solution is shear-thinning. For the experiments we used poly(ethylene-oxide) (PEO) as a model polymer and investigated the effects of rotation speed, solution concentration and gap size (the width of the annular orifice) on the process and the morphology of the obtained fibers. We found that the threshold voltage for generating multiple jets decreased to 12 kv from 35 kv when rotation speed was higher than 60 rpm due to the shearing-reduced viscosity. Additionally, the results showed that fiber diameters increase when increasing the solution concentration. The gap size has a similar effect on the fiber diameter as the needle diameter for classical electrospinning. Figure 1. (a) The electrospinning setup scheme, 1: housing (stator), 2: rotating part (rotor), 3: circular orifice, 4: base plate, 5: high voltage connector, 6: solution inlet, 7: grounded collector screen, 8: electrospinning space, 9: distribution channel, 10: lip seal, 11: bearings, 12: drive shaft; (b) schematic diagram of polymer solution flow in the spinneret Key Words: Needleless electrospinning, Nanofibers, Morphology, Shear-aided electrospinning, Viscosity Acknowledgements: This work was supported by the Higher Education Excellence Program of the Ministry of Human Capacities in the framework of the Nanotechnology research area of the Budapest University of Technology and Economics (BME FIKP-NANO), the Hungarian Research Fund (OTKA K100949), the ÚNKP-17-4-I New National Excellence Program of the Ministry of Human Capacities and BME- KKP, Stipendium Hungaricum Scholarship of Tempus Public Foundation, and China Scholarship Council ( ). [1] Molnár K, Zsombor N, Corona-electrospinning: Needleless Method for High-throughput Continuous Nanofiber Production [J]. Eur. Polym. J. 2016, 74: [2] Molnár K, Kaszás G, High Productivity Shear-aided Electrospinning Apparatus and Method Thereof, US 62/765,216,

114 Continuing Innovation in Electrospinning: New electrode design for improved uniformity and flexibility and optics for process analysis Katerina Rubackova 1, Joshua Manasco 2, Radim Krenek 1, Ivan Ponomarev 1 1 Elmarco s.r.o., Svarovka 621, Liberec XI, 46001, Czech Republic 2 Elmarco, Inc., Morrisville, North Carolina, US The electrospinning process is known to be hampered by highly resistive substrates (i.e. synthetics). This limitation can necessitate the use of a sacrificial spinning layer where, in an added step, the nanofiber membrane will have to be peeled from the spinning layer prior to building the final composite. Elmarco has found a solution to this issue through an innovation in our collecting electrode design. This new design eliminates the barrier normally formed by a highly electrically resistive substrate. Consequently, this new design eliminates the copying effect of the substrate non-uniformity, designs, and defects often seen in nanofiber layers that have been electrospun. This results in an improvement in the microscale uniformity that reflects in higher performance. Furthermore, since the nanofibers are being deposited without bias, there is an opportunity for more relaxed fibers with reduced shrinkage. The industrial camera with Field of View of higher than 27 mm, resolution of 1 px >14 µm and Frame rate up to 500 fps can be implemented to laboratory electrospinning machines to enable obtaining detailed information from the process. The same mechanism willbe used eventually for further analysis of process parametersnot only on laboratory, but also on industrial production technology.parameters which influence the electrospinning process the most and can be analysed: e.g. electrode vibration, frequency of droplet formation, Taylor cones density, thickness of solution film deposition. Key Words: (Nanofibers, Electrospinning, Composite Media, Uniformity, Synthetic Substrates) :M. Malý, et al., Method for application of liquid polymeric material onto spinning cords and a device for production of nanofibers through electrostatic spinning, WO , (2012). 113

115 3D electrospinning for the fabrication of controlled 3D macroscopic nanostructures Michel Vong 1, Richard A. Black 2,Norbert Radacsi 1 1 Institute for Materials and Processes,School of Engineering, The University of Edinburgh, Edinburgh, EH9 3JL, United Kingdom. 2 Department of Biomedical Engineering, University of Strathclyde, Glasgow, G1 1QE, United Kingdom Three-dimensional (3D) electrospinning is a novel technology that permits fabrication of 3D macrostructures, with micro- to nano-sized fibrous bulk.[1,2]based on the combination of 3D printing and electrospinning, it allows precise positioning of the nozzle head and controlled deposition of the electrospun fibers during the whole fabrication process. Under certain conditions, this process is capable of fabricating self-standing 3Dmacroscopic objects made of nanofibers. It is a fast and costeffective technique, and is ~100 times faster than extrusion-based 3D printing. However, the mechanism behind the 3D build-up of the polymeric object is not fully understood. This work shines light on the driving factorsbehind the 3D build-up that is essential for the3d electrospinning process. Several polymers, solvents and different types and quantity of additives have been tested to alter the extrinsic properties of the polymer solution (such as viscosity and conductivity). Through this study, the 3D electrospinning of several different polymers has been achieved. Comparing different polymer systems showed that there wasno direct correlation between the solution viscosity andconductivity for the3d build-up process.however, the presence and type ofadditives (e.g. salts, acids, etc)affected the 3D build-up.for instance, the shape of the macroscopic 3D structure can be controlled by the type of additive.slow-motion capture of the 3D deposition process with the aid ofof a high-speed camera (FASTCAM SA4, Model 500K M1, Photron (Europe) Ltd)revealed multiple Taylor cones emerging from the tip of a single nozzle (Figure 1). It has been demonstrated that both the number of Taylor cones and the spread of nanofiber jets can be directly controlled by the applied voltage and the type of additive. These findings help us understanding the 3D build-up process, improve the precision of the 3D electrospinning process, and presents new opportunitiesfor extending the technique to other polymer systems. Figure 4.Direct effect ofthe additive on 3D electrospinning.sample awas electrospun at +15kV. Sample b was electrospun at +20kV. Pictures a.1 and b.1 werecapturedat a frame rate of 10,000 FPS with a high-speed camera during electrospinning. Pictures a.2 and b.2were taken after electrospinning with a digital camera. The use of specific additives renders the polymer solution more sensitive to the applied voltage. Key Words: Three-dimensional, 3D electrospinning, High-speed camera, Process control Acknowledgement The authors would like to thank the UK Engineering & Physical Research Council (Grant ref. EP/K011952/1) for the high-speed camera. [1] Vong, M. et al.controlled three-dimensional polystyrene micro- and nano-structures fabricated by three-dimensional electrospinning. RSC Adv., 2018,8(28): [2] Sun, B. et al. Advances in three-dimensional nanofibrous macrostructures via electrospinning. Prog. Polym. Sci., 2014,39(5): (2014). 114

116 Influence of Competitive Behavior in Centrifugal Electrospinning Hengwei Hu 1, Kaili Li 1, Yong Liu 2 1 College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing , China. 2 College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing , China. Centrifugal spinning, first inspired by a cotton candy machine, is an attractive method for producing nanofibers at high speed and low cost 1. Centrifugal electrospinning combines the advantages of both centrifugal spinning and electrospinning, and can efficiently prepare nanofibers with controlled morphology. It is the development direction of nanofibers preparation technology 2,3. However, the relationship between centrifugal force and electrostatic force, the most important factors in spinning process, are unclear although the two forces were the most important factors in centrifugal electrospinning. To promote the development of the new method, In this research, the game competition behavior between the centrifugal force and the electrostatic force two factors as well as the influence of the behavior of the game behavior on the nanofibers trajectory, diameter and productivity were studied. In this study, we conducted a primary exploration on the effects of the process parameters of the new spinning way on as-spun fibers. PVP was utilized as raw material. The game behavior between centrifugal force and electrostatic force affecting on the fiber morphology, flying trace, fiber diameter, and the productivity were studied. The experimental results showed a new distribution characteristic of the fiber. And the fiber diameter decrease with the increase of the voltage and the speed. However, there is an optimal voltage, in which condition the fiber diameter would be the minimum. Furthermore, when the voltage was 40 kv, the fiber productivity was 2.36 g min -1, which is hundreds to thousands of times higher than traditional electrospinning of g h -1. Fig.1 Nanofibers SEM and fiber diameter distribution when the rotation speed was 1500 rpm (A1 - A6) and Jet formation of centrifugal spinning (B). Key Words: centrifugal electrospinning, PVP nanofibers, jet path, productivity Acknowledgments: This research was funded by the National Natural Science Foundation of China ( ). : [1]. SARKAR K, GOMEZ C, ZAMBRANO S, et al. Electrospinning to forcespinning TM. Materials Today, 2010, 13 (11) : [2]. GAO H S.Research development in electrospinning technique for manufacturing nanofibers and progress on their apparatus.materials Review, 2017, 26 (s2) : (in Chinese). [3]. MA X L, ZHANG L Y, LI H Y, et al. Preparation of oriented nanowires by melt differential electrospinning. Journal of Textile Research, 2017, 38 (1) :8-12. (in Chinese). 115

117 Hybrid Electrospinning: High Capacity Electrospinning for Large Scale Industrial Nanofibre Production Ali Demir 1, Yusuf Keskin 2, Gülbahar Saat 2, Talha Uzuner 2, Bekir Acıkabak 2, Faik Mıdık 2, Bekir Acıkabak 2, Adullah Aşlamacı 2 1 Department of Textile Engineering, Faculty of Textile Technology and Design, Istanbul Technical University, Gumussuyu, Istanbul, Turkey. 2 Inovenso Technology Inc., Ikitelli Organize Sanayi Mahallesi, YTÜ Ikitelli Teknopark Sokak, Yildiz Teknopark, No:1B/27 Başakşehir, Istanbul, Turkey. The electrospinning process has been the leading and the most widely accepted process for nanofiber production. In all forms of electrospinning process, the polymer as in the form of solution or melt is accelerated, drawn (thinned) and accumulated over the desired surface as nanofiber web. The Figure 1 explains the systematic increase in the nanofiber production by the going from a simple syringe needle to a purpose designed Hybrid Electrospinning Head (HE-Head). (a) (b) (c) Geometry 0 2, ,50 1,72 2 2,50 Electrospinning still photograph Production capacity 1 kv 10 kv 70 kv Figure 1: Production capacity increase from standard syringe needle to HE-Head As it is seen from the Figure 1 that the standard 20G syringe needle is giving stable spinning at low polymer solution throughput rates. It is believed that such a stable electrospinning is very beneficial for lab scale spinning for research purposed. Figure 1 also shows clearly that the HE-Head is enabling multi-spinning multi to create at least 10X (ten fold) production with regular jet formations. It is therefore concluded that the new developed HE-Head is eliminating the major drawbacks of the needleless electrospinning whilst increasing the production capacity of the needle electrospinning. It is believed that the HE-Head will be a major breakthrough in the industrial nanofiber production. Key Words: hybrid electrospinning, high nanofibre production capacity, industrial electrospinning 116

118 Shear-aided electrospinning in a cone-plate configuration Kolos Molnár 1,2, and Haijun He 1 1 Budapest University of Technology and Economics, Faculty of Mechanical Engineering, Department of Polymer Engineering, Műegyetem rkp. 3, H-1111 Budapest, Hungary 2 MTA BME Research Group for Composite Science and Technology, Műegyetem rkp. 3, H-1111 Budapest, Hungary In this study, we introduce a novel needleless electrospinning technology, which uses the mechanical shearing of the solution prior to electrospinning. In the new setup, we use two electrically charged disks, one of which is planar and the other one is conical. There is a gap between them, so the setup looks like a cone-plate rheometer. The rotation of the upper plate generates shear stress in the solution which is fed in between them. Mechanical stresses acting on the solution decrease its viscosity leading to enhanced jet formation. Multiple Taylor-cones forms along the edge of the spinneret and jets are ejected in radial direction. The nanofibers are collected on the lateral surface of a cylindrical collector. In the current study, we used polyethylene-oxide aqueous solution for the electrospinning experiments. The rheological behavior of the solution was measured by a cone-plate viscometer of similar geometry. It made possible to compare the rheology and electrospinning results. In this study we investigated the relation of the fiber diameters and the stress state and we concluded that the fiber diameter clearly decreases as a function of rotation speed. As a function of the shear rate, the average fiber diameter decreased from 260 to 160 nm due to the shear stresses generated by the spinneret and due to the shear-thinning behavior of the solution used. The thinning of the fibers also took place by the acceleration caused by the rotation, which gives a hand in controlling the fiber morphology. The new needleless setup operates with mechanically-induced shear forces that is highly beneficial for both jet formation, fiber morphology and productivity rate. Figure 1. The scheme of the cone-plate electrospinning process. 1: plastic shaft driven by a motor, 2: grounded metal collector ring, 3: electrospinning space with forming nanofibers, 4: rotating electrode, 5: washer for setting gap distance, 6: leading pin, 7: fixed electrode (plate), 8: high voltage connector, 9: solution inlet Key Words: rheometer, needleless electrospinning, shear-thinning, rotation electrospinning Acknowledgements: This work was supported by the Higher Education Excellence Program of the Ministry of Human Capacities in the framework of the Nanotechnology research area of the Budapest University of Technology and Economics (BME FIKP-NANO). This research was also supported by the Hungarian Research Fund (OTKA K116070). [1] Molnar K, Nagy Z K. Corona-electrospinning: Needleless Method for High-throughput Continuous Nanofiber Production [J]. European Polymer Journal, 2016, 74(1): [2] Molnar K. Shear-aided Annular Needleless Electrospinning [J]. Materials Research Express, 2019, 6, in press. 117

119 3.6 Nanofiber for catalyst 118

120 Nanostructured membranes for toxic industrial chemicals (TICs) degradation. Alessandra Lorenzetti 1, Martina Roso 1, Renato Bonora 1, Alessandro Martucci 1, Carlo Boaretti 1, Riccardo Donadini 1, Michele Modesti 1 1 Department of Industrial Engineering, University of Padova, Via Marzolo,9 3513, Italy. Toxic industrial chemicals (TICs) represent a class high-priority chemicals that could pose a serious threat in the event of accidental or intentional release. Consequently, the chemical industry is more and more required to evaluate their facilities for the risk of and vulnerability to a terrorist attack, increase plant security accordingly, and change production methods in an attempt to reduce the use of toxic chemicals [1]. According to this, the development of new solutions in sensing and prevention by using adequate nanostructures with unique properties has gained more interest in the scientific community [2]. The present work is meant to show the production, characterization and the performance of nanostructured membranes obtained by coupling electrostatic-dynamic technologies (i.e. electrospinning, electrospraying and/or electrospinnig) in the abatement of TICs. Electrospun PAN membranes with titanium oxide (TiO 2 -P90) and ferrous sulphate (FeSO 4 ) as catalysts, were produced and tested in the abatement of formaldehyde (90ppm). The employed mechanisms of oxidation were based on: Photo-catalysis: mediated by OH, h +, and superoxide (O 2 - ) radicals generated by photoactivated TiO 2 Photo-fenton reactions, wherein OH radicals obtained by reaction between Fe 2+ and H 2 O 2 ; the latter come directly from UV degradation of formaldehyde; (Fig. 1a); The synergy of photocatalytic and photofenton reactions has been proven (Fig. 1b), for the first time, to led a 88% conversion that was further pushed to 98% with the additional use of ultrasonic waves. (a) Figure 1. (a)mechanisms of oxidation employed in this study; (b) Formaldehyde (CH 2 O) degradation versus time with different configurations. Key Words: toxic industrial chemicals (TICs), formaldehyde, photocalysis, photo-fenton reactions. [1] Bennet, M. TICs, TIMs and Terrorists, Today s Chemist at Work (ACS), 2003, [2] Roso M., Boaretti C., Bonora R., Modesti M., Lorenzetti A. Nanostructured active media for VOCs abatement: the synergy of graphene oxide and semiconductors coupling Ind. Eng. Chem. Res., 2018, 57(49): (b) 119

121 Coral-like Au/TiO 2 hollow nanofibers with through-holes as high efficient catalyst through mass transfer enhancement Guichu Yue, NüWang, Zhimin Cui, Yong Zhao* Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, Beijing Key Laboratory of Bioinspired Energy Materials and Devices, School of Chemistry, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, , P. R. China. One-dimensional hollow nanomaterials were widely used in catalysis field. However, the inner surfaces of one-dimensional hollow nanostructures could not be effectively utilized in liquid reaction due to diffusional limitation caused by the large ratio of length to diameter. Inspired by the structure of coral reef, a template assisted coaxial electrospinning method was developed to prepare TiO 2 hollow nanofibers with through-holes which was further employed as carrier for Au nanoparticles. The Au/TiO 2 hollow through-hole nanofibers showed significantly catalytic activity enhancement to the reduction of 4-nitrophenol in aqueous solution compared with solid and hollow nanofibers counterparts. The through-holes which provided unrestricted macropores for mass transfer in liquid solution were studied to be accounted for the catalytic activity enhancement. The through-hole structures can enlarge the application ranges and efficiencies of 0D or 1D hollow nanomaterials. Key Words: hollow through-hole nanofibers, mass transfer, catalyst, Au NPs [1] Yue G C, Li S, Zhao Y, et al. Coral-like Au/TiO 2 hollow nanofibers with through-holes as high efficient catalyst through mass transfer enhancement [J]. Langmuir, Accept. [2] Li S, Yue G C, Zhao Y, et al. Hierarchically structured electrospinning nanofibers for catalysis and energy storage [J]. Composites Communications, 2019, 13: [3] Hou L L, Wang N, Zhao Y, et al. Bioinspired Superwettability Electrospun Micro/Nanofibers and Their Applications [J] Advanced Functional Materials, 2018,

122 Novel Flexible Al 2 O 3 Nanofibrous Membranes with Multifunctionality for Environmental Remediation Shaohua Hui 1,2 Hui Wang 1,3 and Yan Wang 1 1 Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing , P.R. China. 2 School of Civil Engineering and Transportation, Hebei University of Technology,Tianjin , P.R.China 3 School of Chemical and Biological Engineering, Qilu Institute of Technology, Jinan ,P.R China. Novel flexible self-standing Al 2 O 3 nanofibrous membrane catalysts are fabricated via a facile onepot electrospinning process.[1-3] The embedding of metal nanoparticles is performed simultaneously with the formation of Al 2 O 3 nanofibers. The Al 2 O 3 membranes show remarkable mechanical properties with tensile stresses as high as MPa. Notably, the Al 2 O 3 membranes exhibit multifunctionality with excellent performance characteristics, which could be used as catalysts for organic pollutants removal, and oxidation of CO to CO 2. Over 87% of BPA is degraded within 180 min in the membrane reactor using the 1 wt% Cu Al 2 O 3 membrane at neutral ph values with H 2 O 2 addition.[1] For Co Al 2 O 3 membranes, the divalent cobalt ions distribute uniformly in the fibers by forming Al O Co bonds, which are responsible for the catalytic activity of the membranes.[2] The membranes also exhibit excellent filtration performance, clearly decreasing the turbidity of water, and meet the high efficiency of particulate air filter standards.[3] The excellent flexibility, satisfying mechanical property, and multifunctionality extend the range of potential application of the Al 2 O 3 membranes. Fig. 1 Optical images of the novel Al 2 O 3 membranes Key Words: Electrospinning, Al 2 O 3, flexible membranes, water purification Acknowledgements: This work was financially supported by the projects of the National Natural Science Foundation of China (No ) [1] Wang Y, Li J, Sun J, et al: Electrospun flexible self-standing Cu Al 2 O 3 fibrous membranes as Fenton catalysts for bisphenol A degradation [J]. Journal of Materials Chemistry A 2017, 5(36), [2] Wang Y, Zhao S, Fan W, et al: The synthesis of novel Co Al 2 O 3 nanofibrous membranes with efficient activation of peroxymonosulfate for bisphenol A degradation [J]. Environmental Science: Nano 2018, 5(8), [3] Wang Y, Zhan S, Di S, et al: Novel Flexible Self-Standing Pt/Al 2 O 3 Nanofibrous Membranes: Synthesis and Multifunctionality for Environmental Remediation [J]. ACS Applied Materials & Interfaces 2018, 10(31),

123 Development of mesoporous carbon fibers by electrospinning for PEFC application Tingwei Huang 1, Mayumi Nagayama 2, Kazunari Sasaki 1-4, and Akari Hayashi 1-5 Kyushu Univ. 1 Department of Hydrogen Energy System, 2 COI-C2RSC, 3 NEXT-FC, 4 International Research Center for Hydrogen Energy, 5 Q-PIT, 744 Motooka, Nishi-ku, Fukuoka, , JAPAN. Introduction Polymer electrolyte fuel cells (PEFCs) were considered as one of clean energy technologies for our near future because of their high energy efficiency with low carbon emission. Among the components of PEFCs, electrodes, which are usually called electrocatalyst layers, are important components to determine PEFC performance. The electrocatalyst layers are usually made by noble metal particles dispersed on carbon supports, and their high cost is one of the reasons to prevent wide spread of PEFC technologies. In order to increase the efficiency and durability of electrocatalysts, our group has been focusing on developing carbon supports, and we have already demonstrated the improvement of durability by utilizing mesoporous carbon (MC) with 6-8 nm pore size [1]. In this study, we are trying to further improve the efficiency of electrocatalysts by controlling three dimensional structure of electrocatalyst layers in the micrometer scale by making our MC into carbon fibers with the electrospinning technique. Experimental MC fibers (MCFs) were made by electrospinning of the solution containing carbon precursors, the resol-formaldehyde type resin polymer and polymer template Pluronic F127, after adding polyvinyl alcohol (PVA) as a polymer additive. Then, Pluronic F127 was removed by heat treatments to generate mesopores. In this study, precursor polymers were catalyzed under different ph conditions. The mesoporosity and conductivity were analyzed by N 2 sorption and electro-impedance spectroscopy (EIS) methods, respectively. Furthermore, after spray printing carbon dispersion on the substrate, the cross-section was observation by FIB-SEM to evaluate the mechanical strength. Besides above material evaluations, electrochemical analyses, such as electrochemical surface area (ECSA) and Oxygen reduction reaction (ORR) activity, were done with the half-cell setup after Pt deposition. Results, discussion, and conclusions The common structure of MCF is shown in Figure 1. Based on the results of N 2 sorption, the mesopore size of MCFs decreased as ph values of precursor polymers, which means that the ph value plays an important role in controlling of pore size. According to the conductivity measurements by EIS, MCFs showed a better conductivity than regular MC and common carbon materials. It might be due to the fact that the fiber-fiber contact provides better conductive-path than the particle-particle contact. Moreover, regarding to the mechanical strength, the spray-printed MCF layer showed less change in the thickness after compression in comparison to the regular MC and common carbon. This probably comes from higher elasticity provided by the fiber structure, possibly leading to better mass transfer for PEFC application. About electrochemical evaluation through a half-cell setup, MCF-based catalyst showed similar ECSA and ORR activity to regular MC-based catalyst. Therefore, the additional improvement in mechanical properties of MCFs most likely leads to a better performance in practical PEFC operation. Key Words Electrospinning, Carbon fiber, Mesoporous structure, Catalyst support, Fuel Cells. Figure 1. SEM images of MCF [1] Minamida Y, Noda Z, Hayashi A, and Sasaki K, Development of MEAs with Pt/Mesoporous Carbon as a Cathode Catalyst. ECS Transactions, 64 (3) (2014).

124 3.7 Nanofiber for energy

125 Construction of CH 3 NH 3 PbBr film with Ultra-high Stability by Electrospinning Methods and Its Light-Emitting Diodes Huan Bi 1,2, Fangyu Liu 1,2, Zhu Mao 1, Yuehui Zhai 1,2, Mian Wang 1,2, Wei Li 2, Shiwei Wang 1,2,* 1 Advanced Institute of Materials Science, Changchun University of Technology, Changchun , P. R. China, 2 School of Chemical Engineering, Changchun University of Technology, Changchun , P. R. China Recently, organometallic halide perovskites (OMHP) have demonstrated their bright future in not only photovoltaic cells but also the luminescent device. However, their poor stabilities in water, oxygen, light and temperature have greatly limited their practical applications. Here, (MAPbBr composite fiber membranes with super good stability have been successfully constructed by electrospinning technology. 70% of the fluorescence intensity of MAPbBr is maintained after soaking in water for 30 days, and 85% after leaving at 95 conditions for 350 minutes, and 90% after irradiating under ultraviolet light for 100 h. The excellent stabilities of the MAPbBr fiber membranes are attributed to the spatial effect of MAPbBr 3, the hydrophobicity of PS fiber, and the formation of hydrogen bonds between the MAPbBr 3 crystal and the PS fiber. In addition, a high-brightness white light-emitting diode based on MAPbBr fiber has been fabricated, which fully demonstrates its application in the field of color conversion. Key Words: Organometallic halide Perovskite; CH 3 NH 3 PbBr Light-Emitting Diodes; Stability; Electrospinning Acknowledgements: The authors gratefully acknowledge the funding of this research by the National Natural Science Foundation of China ( ); Project plan of special fund for industrial innovation in Jilin Province (2017C048); The Planning Project of Science and Technology of Changchun City (17DY033); The Development Planning Project of Jilin Province Science and Technology ( GX). [1] Liao, H. et al. A General Strategy for In Situ Growth of All-Inorganic CsPbX 3 (X = Br, I, and Cl) Perovskite Nanocrystals in Polymer Fibers toward Significantly Enhanced Water/Thermal Stabilities [J]. Advanced Optical Materials, 2018, 6(15): [2] Zhou, Q.,Bai, Z.,Lu, W.G.,Wang, Y.,Zou, B.&Zhong, H. In Situ Fabrication of Halide Perovskite Nanocrystal-Embedded Polymer Composite Films with Enhanced Photoluminescence for Display Backlights [J]. Advanced Materials, 2016, 28(41):

126 Amorphous red phosphorus embedded in the free-standing nitrogen-doped porous hollow carbon nanofibers enabling superior sodium/potassium storage performance Ying Wu 1, Yan Yu 1* 1 Department of Materials Science and Engineering, University of Science and Technology of China, Key Laboratory of Materials for Energy Conversion, Chinese Academy of Sciences (CAS), Hefei, Anhui, , China. Sodium/Potassium-ion batteries (NIBs and KIBs) are promising alternative tolithium-ion batteries (LIBs) for large-scale renewable energy storage.however, the biggest challenge lies in the lack of suitable electrode materials with long cycle life and high reversible capacity.phosphorus (P)-based materials have drawn extensive attentionowning to its high theoretical capacity.however, the cyclic performance is limited by the poor electronic conductivity and the huge volume change. To overcome the issues,we boost the sodium/potassium storage performance of red P by encapsulating red P nanoparticles within the electrospun nitrogen (N)-doped porous hollow carbon nanofibers (denoted as red The outstanding potassium sodium performance could be achieved with stable long cycling performance with high reversible capacities at both low current density (650 mah g -1 at 0.1 A g -1 after100 cycles) and high current density (465 mah g -1 at 2 A g -1 after800 cycles).the rationally designed nanoarchitecture allows for the expansion of red P without deforming the carbon matrix or disrupting the SEI on the outside surface. Key Words:Sodium/Potassium ion batteries, red phosphorus, porous hollow, carbon nanofibers,nitrogen doping Acknowledgements: This work was supported by the National Key R&D Research Program of China (Nos. 2018YFB , 2016YFB ), the National Natural Science Foundation of China (Nos , , ), the Fundamental Research Funds for the Central Universities (WK ). [1]Wu, Y.; Hu, S.; Xu, R.; Wang, J.; Peng, Z.; Zhang, Q.; Yu, Y., Boosting Potassium-ion Battery Performance by Encapsulating Red Phosphorus in Free-standing Nitrogen-doped Porous Hollow Carbon Nanofibers [J]. Nano letters 2019,19 (2), [2] Wu, Y.; Xing F.; Xu R.; Cheng X.; Li D.; Zhou X.; Zhang Q.; Yu Y., Spatially Confined and Chemical Bonding Amorphous Red Phosphorus into Nitrogen Doped Porous Carbon Tubes Leading to Superior Sodium Storage Performance [J]. Journal of Materials Chemistry A, 2019, DOI: /C9TA01039D

127 Flexible piezoelectric nanogenerators based on electrospun BaTiO 3 nanowires and polydimethylsiloxane elastomer Jing Yan 1,2, Guang Yang 1,2, Young Gyu Jeong 3, Weimin Kang 1,2 Bowen Cheng 1,2 1 School of Textile Science and Technology, Tianjin Polytechnic University, Tianjin , China. 2 State Key Laboratory of Separation Membranes and Membrane Processes/National Center for International Joint Research on Separation Membranes, Tianjin Polytechnic University, Tianjin , China. 3 Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University, Daejeon 34134, Republic of Korea. Piezoelectric nanogenerator, harvesting energy from mechanical actions in our living environments, holds great promise to power sustainable self-sufficient micro/nano-systems and mobile/portable electronics. In this work, flexible nanogenerators were fabricated by applying polydimethylsiloxane (PDMS) elastomer directly on BaTiO 3 nanowires and following curing technique. For the purpose, BaTiO 3 nanowires were prepared by an electrospinning technique utilizing a sol-gel precursor and following calcination process. Firstly, the alignment effects of BaTiO 3 nanowires in PDMS matrix on their performance were studied. The nanogenerator with BaTiO 3 nanowires aligned vertically achieved high piezoelectric performance of an output power of μw with maximum voltage of 2.67 V and current of na under a low mechanical stress of 2 kpa. Then, roles of multi-walled carbon nanotube (MWCNT) on the piezoelectric properties of flexible PDMS-based nanogenerators with BaTiO 3 nanowires (10-50 wt%) were further investigated by incorporating different contents of MWCNT ( wt%). The nanogenerator with 2.0 wt% MWCNT and 40 wt% BaTiO 3 nanowires generated the highest average output voltage of ~3.73 V, current of ~1.37 μa, and power of ~0.33 μw, which was feasible to light up a commercial LED and to charge a capacitor after rectification, revealing the potentiality in powering self-sufficient nanodevices and wireless electronics. Key Words: BaTiO 3 nanowire, Polydimethylsiloxane, carbon nanotube, nanogenerator, Piezoelectricity. Acknowledgements: The work was supported by the Natural Science Foundation of Tianjin City (17JCYBJC41700), Scientific Research Project of Tianjin Municipal Education Commission (2017KJ067) and Tianjin Scientific Research Foundation for the Returned Overseas Chinese Scholars ( ). [1] Guo Y, Zhang X S, Wang Y, et al. All-Fiber Hybrid Piezoelectric-Enhanced Triboelectric Nanogenerator for Wearable Gesture Monitoring[J]. Nano Energy, 2018, 48: [2] Yan J, Liu M, Jeong YG, et al. Performance enhancements in poly(vinylidene fluoride)-based piezoelectric nanogenerators for efficient energy harvesting[j]. Nano Energy, 2019, 56:

128 Preparation of free-standing one-dimensional nanofibers electrodes by electrospinning and its application in alkali metal-ion batteries Yan Yu 1 1 Department of Materials Science and Engineering, University of Science and Technology of China, Key Laboratory of Materials for Energy Conversion, Chinese Academy of Sciences (CAS), Hefei, Anhui, , China. Alkali metal-ion batteries, such as lithium-ion batteries (LIBs), sodium-ion batteries (NIBs) or potassium ion batteries (KIBs) have drawn great attention and developed rapidly in recent years. Development of electrode materials with nanoarchitecture is very essential to realize high performance battery system. Among various nanostructured electrode materials, one dimensional fiberous structure is quite attractive for electrode materials due to their advantages (large surface to volume ratio, high electrode-electrolyte contact area, fast ions diffusion and good strain accommodation in the open and loose structure), which is superior to those of bulk materials. Electrospinning has attracted many attentions in the design and preparation of 1D nanostructured electrode materials for Alkali metal-ion batteries, due to the versatility and facility.therefore, the design of one dimensional nanofibers electrodes via electrospinning is confirmed to be an effective and facile way, with the formation of pure carbonaceous nanofibers or the combination of the carbonaceous nanofibers with active materials. In this talk, we summarize a variety of electrospun anode (Sb/C, TiO 2, Ge/C, P/C, MoS 2 etc) and cathode materials (Na 3 V 2 (PO 4 ) 3 /C, Se/C, etc) of LIBs and NIBs, which were prepared by electrospinning technique. 1-4 The synthetic methods, reaction mechanisms, electrochemical properties, achievable capacities are systematically discussed in this talk. Key Words:Lithium/Sodium/Potassium ion batteries, free-standing, nanofibers, electrodes Acknowledgements: This work was supported by the National Key R&D Research Program of China (Nos. 2018YFB ), the National Natural Science Foundation of China (Nos , ), the Fundamental Research Funds for the Central Universities (WK ). [1]. Abouimrane, A.; Dambournet, D.; Chapman, K. W.; Chupas, P. J.; Weng, W.; Amine, K. Journal of the American Chemical Society 2012, 134, (10), [2]. Yao, Y.; Zeng, L.; Hu, S.; Jiang, Y.; Yuan, B.; Yu, Y. Small 2017, 13, (19), [3]. Wu, Y.; Liu, X.; Yang, Z.; Gu, L.; Yu, Y. Small 2016, 12, (26), [4]. Zhu, C.; Mu, X.; van Aken, P. A.; Yu, Y.; Maier, J. Angewandte Chemie 2014, 126, (8),

129 Nanoengineering to Achieve High Sodium Storage: A CaseStudy of Carbon Coated Hierarchical Nanoporous TiO 2 Microfibers Gao Yuan, Yong Zhao, NüWang* Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, Beijing Key Laboratory of Bioinspired Energy Materials and Devices, School of Chemistry, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, , P. R. China. Abstract Nanoengineering of electrode materials can directly facilitate sodium ionaccessibility and transport, thus enhancing electrochemical performance in sodium ion batteries. Here, highly sodium-accessible carbon coated nanoporoustio 2 microfibers have been synthesised via the facile electrospinningtechnique which can deliver an enhanced capacity of 167 ma h/g after 450 cycles at current density of 50 ma/g and retain a capacity of 71 ma h/g at the high current rate of 1 A/g. With the benefits of their porous structure, thin TiO 2 inner walls, and the introduction of conductivecarbon, the nanoporous TiO 2 /C microfibers exhibit high ion accessibility, fastna ion transport, and fast electron transport, thereby leading to the excellentna-storage properties presented here. Nanostructuring is proven to be afruitful strategy that can alleviate the reliance on materials intrinsic nature;and the electrospinning technique is versatile and cost-effective for the fabricationof such an effective nanoporous microfiber structure. Key Words:nanoporous; electrospinning; sodium ion batteries;nanoengineering : [1] Wang N, Gao Y, Wang Y X, et al. Nanoengineering to achieve high sodium storage: A case study of carbon coated hierarchical nanoporous TiO 2 microfibers[j]. Advanced Science, 2016, 3(8): [2] Chen H, Di J, Wang N, et al. Fabrication of hierarchically porous inorganic nanofibers by a general microemulsion electrospinning approach[j]. Small, 2011, 7(13): [3] Hou L L, Wang N, Zhao Y, et al. Bioinspired Superwettability Electrospun Micro/Nanofibers and Their Applications [J] Advanced Functional Materials, 2018,28(49):

130 Simple Decoration of Ir Nanoparticles on Carbon-based Air Cathode as an Effective Catalyst for Long Life Cycle Lithium-Oxygen Batteries Jong Seok Nam 1, Ji-Won Jung 1, Seok-Won Song 1, Sang-Joon Kim 1, and Il-Doo Kim 1,* 1 Department of Materials Science & Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-Ro, Yuseong-Gu, Daejeon, , Republic of Korea. For decades, global warming and environmental pollution have become acute problems in the world because of the use of fossil fuels. To solve these, eco-friendly lithium-oxygen batteries (LOBs) with high energy density have been attracting much attention. However, LOBs are still suffering from short cycle life and high overpotential owing to insulating discharging byproducts such as Li 2 O 2 and Li 2 CO 3. In this work, we reported a straightforward strategy to improve energy efficiency and cyclability with low overpotentials of LOBs; by using Iridium (Ir) nanoparticles (NPs), which are representative Oxygen evolution reaction (OER) / Oxygen reduction reaction (ORR) catalysts, sputtered on porous/conductive carbon nanofiber (CNF), we effectively catalyzed both ORR and OER[1]. the CNF was synthesized through the process of stabilization at 250 C and carbonization process at 900 C, and then the Ir NPs were simply coated on the CNF by RF-sputtering. The has dual functions on (i) overpotential characteristics for ORR/OER and (ii) prevention the parasitic reactions such as carbon decomposition: first, the composed of highly catalytic Ir and conductive CNF support showed the lower overpotential of 0.2 V compared to that of CNF for OER. Second, by covering the entire surface of the CNF with the Ir NPs, the direct contact between Li 2 O 2 and the CNF was prevented, thereby alleviating the carbon decomposition and Li 2 CO 3 formation. The synergy between Ir and CNF plays a critical role in enhancing the lifespan of LOB with the compared with the pristine CNF. Figure 1. In-situ SEM and TEM images of (a, b) cross section SEM images of (c, d, e, f) TEM images of (g) EDS mapping images of Key Words: Lithium-oxygen battery, Binder-Free, Bifunctional catalyst, Carbon, Sputtering [1] Y. Gorlin and T. Jaramillo, A bifunctional nonprecious metal catalyst for oxygen reduction and water oxidation. J. Am. Chem. Soc., 2010, 132:

131 Electrospun Nanostructures for High-Performance Perovskite Solar Cells Tao Ye 1, Shaoyang Ma 2, Seeram Ramakrishna 3 1 Department of Physics, School of Science, Beijing Jiaotong University, No.3 Shang Yuan Cun, Hai Dian District, Beijing , China. 2 School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore , Singapore. 3 Department of Mechanical Engineering, National University of Singapore, Singapore , Singapore. Electrospinning have been proved as a powerful technique to fabricate various functional nanostructures, which has been used in various hot and key research fields, such as batteries, catalysis and solar cells Here, aligned and flexible carbon nanomaterials and various TiO 2 nanostructures have been fabricated via electrospinning technique. The optical intensity distribution and charge carrier extraction/transport has been enhanced by introducing the above-mentioned nanostructures, resulting in remarkably improved device performance. This technique has demonstrated great potential in constructing functional materials for efficient perovskite solar cells. Figure 1. The schematic and application fields of the electrospinning technique and electrospun nanofibers. Key Words: Electrospinning, perovskite, solar cells, nanostructures, efficiency [1] Ye, T, Ma, S, Jiang, X, et al. Electrosprayed TiO 2 nanoporous hemispheres for enhanced electron transport and device performance of formamidinium based perovskite solar cells [J]. Nanoscale, 2017, 9(1): [2] Ye, T, Jiang, X, Wan, D, et al. Ultrafast Photogenerated Hole Extraction/Transport Behavior in a CH 3 NH 3 PbI 3 /Carbon Nanocomposite and Its Application in a Metal Electrode Free Solar Cell [J]. ChemPhysChem, 2016, 17(24): [3] Ma, S, Ye, T (Co-first author), Wu, T, et al. Hollow rice grain-shaped TiO 2 nanostructures for high-efficiency and large-area perovskite solar cells. Solar Energy Materials and Solar Cells, 2019, 191:

132 Initial Modulus(GPa) Tensile Strength(GPa) Current Density(A/cm -3 ) Reinforcement of lignin-based carbon fibrous multi-porous film with nanocellulose whiskers Qiaozhen Yu Department of Materials and Textile Engineering, Zhejiang experimental center of materials and textile engineering, Jiaxing University, Jiaxing Zhejiang , P. R. China. To improve the property of lignin-based carbon fibrous (CF) muti-porous film, cellulose nanocrystals (CNCs) were as reinforcing agent and added into the fabrication of lignin-based CF muti-porous film by electrospinning. The effect of the content of CNCs on the morphology, conductivity, mechanical and electrochemical property of the film was investigated systematically. The results show that with the increase of the content of CNCs, the diameter of lignin-based carbon/cncs composite fiber gradually increased; initial modulus, fracture strength of the CF multi-porous film all increased except the fracture strength of the film with CNCs of 8.0%, while the elongation at break fluctuated up and down and the conductivity decreased first, then increased. The lignin-based CF multi-porous film with CNCs of 5.0wt% had the highest tensile strength and the film with CNCs of 8.0wt% had the highest initial modulus. The lignin-based CF multi-porous film with CNCs of 8.0wt% had an initial modulus, tensile strength and elongation of ±17.14 GPa, 6.30±0.86 GPa and 3.08%, respectively, which is comparable to that of PAN based carbon fibers. The specific capacitance of CF multi-porous film with CNCs was lower than that of pure one except of the film with 2.5wt% of CNCs which had the largest capacitance of 18.81F/g Content of CNCs(%) Content of CNCs(%) ToC figure SEM images of lignin-based carbon/cncs fibrous multi-porous film The effect of content of CNCs on the mechanical and electrochemical properties of lignin-based carbon/cncs fibrous multi-porous films Potential(V) (B) 0% 0.8% 1.0% 1.5% 2.5% 5.0% 8.0% Key Words: Cellulose crystal, lignin-based carbon fiber, electrospinning, property [1] L. T. Lin, Y. J. Li, Frank K. Ko, Fabrication and Properties of Lignin Based Carbon Nanofiber [J]. Journal of Fiber Bioengineering and Informatics, 2013, 6(4): [2] E. Frank, F. Hermanutz, M. R. Buchmeiser, Carbon fibers: precursors, manufacturing, and properties [J]. Macromolecular materials and engineering, 2012, 297: [3] D. A. Baker, N. C. Gallego, F. Baker, On the characterization and spinning of an organic-purified lignin toward the manufacture of low-cost carbon fiber [J]. J. Applied Polymer Sci., 2012,124: 227

133 Metal-Organic-Frameworks DerivedMetal Sulfides/Selenides Encapsulated in Electrospun Carbon Nanofibers towardsenergy Storage/Conversion Application Xiaojie Yin, ChuanweiZhi,Yun Gao, Pingping Du, Li-Ping Lv* and Yong Wang* Department of Chemical Engineering, School of Environmental and Chemical Engineering, ShanghaiUniversity, Shanghai200444, address: The rapid consumption of fossil fuels has sparked extensive research interest in the development of efficient alternative energy conversion and storage systems, such as lithium ion batteries (LIBs), supercapacitors (SCs), electrocatalyst and so on. Transition metal sulfides/selenides (TMS) have become promising candidates for the energy conversion or storage systems due to their high theoretical energy storage capacities. Nevertheless, the generally poor electronic conductivity still hinders their application andstructural design of TMS is therefore needed. Promisingstrategies includethe application of multi-metal sulfides/selenides due to their richer redox chemistry and hybridization with carbon-based materials owing to their high conductivity. Herein, we report a series of bi-metal sulfides/selenides (BMS/Se), i.e.ni-co-s/se and Co-Zn-S/Se derived from bimetal organic frameworks (MOFs) and composite them with carbon nanofibers (CNF) by electrospinning. Due to the synergetic effect between the metal sulfides/selenides and carbon nanofibers, these exhibit excellent electrochemical performances whenused as anode materials for LIBs (1113 mah g -1 at 0.1 A g -1 ), supercapacitors ( C g -1 (1891 F g -1 ) at 1 A g -1 ) and electrocatalyst for oxygen reduction reaction (ORR) (half-wave potential of V (vs. RHE), a high limiting current density of 5.05 ma cm -2 ). Figure1.Characterization of (a) TEM image; (b) cycling performances as anode materials in LIBs; characterization of (c) TEM image; (d) galvanostaticchargedischarge (GCD) curves in SCs; (e) linear sweep voltammetry (LSV) curves when used as electrocatalyst for ORR. Key Words:Bi-metal sulfides/selenides,carbon nanofibers, Lithium ion batteries, Supercapacitors and Electrocatalyst. Reference: [1] YinX J,ZhiC W, LvL-P, et al. Multilayer 3 O Quantum Dots Hollow Spheres for High-Performance Lithium-ion Batteries and Supercapacitors [J]. Journal of Materials Chemistry A, 2019, 7(13), [2] Yin X J, Lv L-P, Wang Y, et al. Functionalized Graphene Quantum Dot Modification of Yolk- Shell NiO Microspheres for Superior Lithium Storage [J]. Small, 2018, 14(22): [3] Yin X J, Lv L-P, Wang Y,et al. Boosting Lithium-ion Storage Performance by Synergistically Coupling Zn 0.76 Co 0.24 S with N-/S-doped Carbon and Carbon Nanofiber [J]. Chemical Engineering Journal, 2018, 346:

134 3.8 Nanofiber for photonic and electronic

135 Direct-Writing Structure-Color Patterns on the Electrospun Colloidal Fibers toward Wearable Materials Jingxia Wang 1*, Shujian Yuan 1, Zhaoxia Guo 2, Lei Jiang 1 1 Tehcnical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, , China. 2 Key Laboratory of Advanced Materials(MOE), Department of Chemical Engineering, Tsinghua University, Beijing , P.R. China Currently, wearable optic-electronic materials is of growing research interest for nextgeneration artificial intelligence equipment, integrating multiple functionality, such as high bendability or stretchability, transparency, conformal contacts on biosurfaces, and many others. Particularly, combining the colloidal crystals with fiber altogether has became an important research topic, such as directly electrospinning colloidal fiber, coating colloidal crystals on the surface of fiber or fabric. Typically, Zhang et al. reported a detailed investigation on the electrospun process of colloidal suspension (mixture of polymer microspheres and polyvinyl alcohol (PVA)), presenting colloidal fiber films with noniridescent structure color 1. This work makes it possible for dye-free textile coloration. However, more potential applications are greatly expected for the structure color electrospun fiber. Particularly, few of papers refer to direct writing structure color pattern on electrospun colloidal fiber owing to the low resolution aroused from prompt wetting and spreading of water on the as-spun fiber 2, to our best knowledge. Herein, we demonstrated a direct water writing colorful colloidal patterns on electrospun fiber by inkjet printing. The printability and resolution was improved based on the modulation of wettability of the colloidal fibers. The high-quality patterns such as letter or two-dimensional code, were flexibly designed and printed on colloidal fibers. And the pattern was easily transformed onto flexible substrate, i.e., a printed flexible bracelet. The colloidal fiber film was electrospun from aqueous mixture of colloidal particles of poly(styrene-methyl methacrylate-acrylic acid) and PVA, the color could be modified by changing the latex diameter. This work will open a door for the extended development and applications of novel wearble materials/devices based on electrospun colloidal fibers. Key Words: electrospin, colloidal fiber, inject printing, pattern [1]Yuan W; Zhou N; Shi L; Zhang K Q, Structural coloration of colloidal fiber by photonic band gap and resonant mie scattering, ACS Appl. Mater. Interfaces, 2015, 7, [2] Zheng S, Du M, Miao W N, Wang D Y, Zhu Z P, Tian Y, Jiang L. Ye Tian, 2D Prior Spreading Inspired from Chinese Xuan Papers Adv. Funct. Mater. 2018,

136 A direct-write nanofibers for low-cost, high-throughput microscale lithography Jonghyun Kim, Dongwoon Shin, and Jiyoung Chang Department of Mechanical Engineering, University of Utah, Salt Lake City, UT, United States, 84112, The conventional UV photolithography requires complicated mask preparation and access to clean-room facilities. Various lithography processes including e-beam lithography, focused-ion-beam, and AFM based lithography have been proposed recently. However, they entail high process cost, expensive equipment cost and low throughput in general. There have been strong demands to enable an affordable table-top scale, high-throughput lithography process to expedite research and fabrication. Here, we present a novel fiber-based lithography that enables a fast, direct-write mask and tabletop scale exposure system through physical birefringent effect [1] of electromagnetic light wave using optical anisotropy of the polymeric fiber. (a) The fiber masks are prepared via near-field electrospinning [2]. (b) Selective transmission of an incident UV wave is allowed through two perpendicularly positioned polarizers. Only the UV waves passing the patterned fiber can reach the target Photoresist (PR). As a result, the etching pattern of the PR follows the shape of the fiber pattern. With this method, (c) continuous line and (d) curves can be created on PR. Plus, (e) isolated dot and array can be generated through cross-stacking of fibers. Additionally, precise control of intensity and fiber formation enables transformation of 1D into (f) 2D-area pattern. (g) A gold serpentine circuit formed on flexible film to demonstrates practical use of the fiber lithography. The fibrous birefringence exposure demonstrates the facile microscale lithography and can be easily applicable to various substrate including flexible, stretchable and non-planar substrates. It is applied to lithography using simple tools and inexpensive polymer, while not sacrificing the resolution and speed. Key Words: Near-Field, Birefringence, Fiber, UV, Lithography [1] Kim D S, Čopar S, Tkalec U and Yoon D K 2018 Mosaics of topological defects in micropatterned liquid crystal textures Sci. Adv. 4 eaau8064 [2] Kim J, Shin D, Han K-B and Chang J 2018 A Quantification of Jet Speed and Nanofiber Deposition Rate in Near-Field Electrospinning Through Novel Image Processing J. Micro Nano-Manufacturing

137 3.9 Nanofiber for filtration

138 Electrospun polyvinylidene fluoride-based fibrous nanocomposite membranes reinforced by cellulose nanocrystals for efficient separation of water-in-oil emulsions Qingxiang Wang, Dong Wang, Xue Wang, Wanli Cheng, and Guangping Han* 1 Key Laboratory of Bio-based Material Science and Technology (Ministry of Education), Northeast Forestry University, , Harbin, China. A hydrophobic-oleophilic nanofibrous membrane was successfully produced by incorporating cellulose nanocrystals (CNC) into polyvinylidene fluoride (PVDF) via an electrospinning process. The effects of levels of CNC loading on membrane microstructure, mechanical properties, water and oil contact angle and efficacy of separating oil from water-in-oil emulsions were investigated. The results demonstrated that the incorporation of CNC improved the flux of emulsion separation of the fabricated fibrous membranes by optimizing microstructure and porosity. For water-in-toluene emulsions, a higher flux of 5842 L m-2 h-1 with high separation efficiency of 97% was obtained for membranes with CNC addition of 4 wt%, 4 times greater than that of pure PVDF membrane (1495 L m-2 h-1). Most importantly, as increasing CNC loading levels, membranes demonstrated good mechanical performance while being easily recycled, which is environmentally friendly, flexible and sustainable.. Key Words: Cellulose nanocrystals; Electrospinning; PVDF; Emulsified oil; Nanofibrous membranes Acknowledgements: This work is supported by the National Natural Science Foundation of China (Gant No ). [1] Wang X, Cheng W, Wang D, et al. Electrospun polyvinylidene fluoride-based fibrous nanocomposite membranes reinforced by cellulose nanocrystals for efficient separation of waterin-oil emulsions[j]. Journal of Membrane Science, 2019, 575:

139 Nanofiber Based Solution for Air Filtration: Preparation and Characterization Yanbo Liu 1,2, *, Lingling Liu 1, Ming Hao 2, Zheng Huang 1, Wenjun Tian 1, and Fangying Li 1 1 School of Textile Science and Engineering, Wuhan Textile University, Wuhan, China. 2 School of Textile Science and Engineering, Tianjin Polytechnic University, Tianjin, , China Abstract: Air pollution and harmfulness from PM2.5 is still a severe problem worldwide, especially in China. Recent research has indicated that iron magnetic particles could even travel to human brain through hemokinesis, resulting in so-called PHD similar to the brain affected by Alzheimer s disease. Electrospun nanofiber webs are systematically investigated for their applications as air filtration media, in terms of filtration efficiency (FE) and pressure drop (Δ P), to provide a problem solving solution for currently existing PM2.5 issues, particularly the PM 0.3μm. Firstly, the combination of electrostatic spinning and electrostatic charging technologies is explored, creating a novel type of nanofiber-based filter media with high filtration efficiency, low pressure drop, and semi-durability, which is composed of polymer electrets and inorganic electrets. Secondly, the effects from corona treatment on the filtration performance of the web are analyzed. The results show that there exists positive correlation between filtration efficiency and surface potential, and corona treatment can increase the filtration performance of the electret contained nanofiber web due to the electrostatic attraction from the charged nanofiber web to the particles in the polluted air. Besides, the surface charge decay behavior when exposed to air and the way how to keep the charges inside the nanofiber web are also discussed in the current report. Effect of corona treating voltage on filtration performance Key Words: corona discharge, nanofiber filter media, surface potential, semi-durable effect Acknowledgements: This study has been financially supported by NSFC under the project approval No [1] Yu B, Han J, He X, et al. Effects of Tourmaline Particles on Structure and Properties of Polypropylene Filtration Melt-Blown Nonwoven Electrets[J]. Journal of Macromolecular Science, Part B, 2012, 51(4): [2] Wang S, Zhao X, Yin, et al. Electret Polyvinylidene Fluoride Nanofibers Hybridized by Polytetrafluoroethylene Nanoparticles for High-Efficiency Air Filtration[J]. ACS Applied Materials & Interfaces, 2016, 8(36): [3] Zhang Q, Yang T, Si X L, et al. Deciphering Effects of Surface Charge on Particle Removal by TiO 2 Polyacrylonitrile Nanofibers[J]. Aerosol and Air Quality Research, 2017, 17(7):

140 Preparation of Flexible 2 Nanofiber Membrane for Air Cleaning Linghui Yin, Min Hu, Zhaoxiang Zhong*, Weihong Xing National Engineering Research Center for Special Separation Membrane,College of Chemical Engineering,Nanjing Tech University,Nanjing ,Jiangsu,China. Particulate matter (PM) and chemical gaseous pollutants (SO 2, NO x, VOCs, etc.) severely threaten to human health. Synergistic removal of PM and chemical gaseous pollutants is still a challenge. Metal organic frameworks (MOFs) hold the promise for poisonous pollutants capture due to the high surface area, regular micropores and rich functionalities. Here, we demonstrate a facile synthesis route for insitu growing ZIF-67 on flexible silica nanofiber membrane 2 NFM) that achieves high MOFs loadings, modified pores and high adsorptive capacities, compared with the route dispered MOFs in polymer nanofiber which may cause the embedding of MOFs and result in low adsorption. What s more, the surface charge of ZIF-67 plays a key role in enhancing the electrostatic interactions between PM and the 2 nanofibers which could improve the PM removal efficiency of the membrane. The results show that 2 NFM has a robust adsorption on SO 2 of mg/g at room temperature and relative humidity of 55 ± 5%. The filtration efficiency of PM2.5 (0.3 μm NaCl aerosol) is 99.79% and the pressure drop is 247 Pa (2 cm/s). This work not only proposes a new strategy to fabricate multifunction nanofiber membrane but also holds great promise for improving air quality. Fig.1 (a) Schematic and (b) FESEM image of the 2 NFM, (c) SO 2 dynamic adsorption of the 2 NFM at room temperature and humidity of 55 ± 5% Key Words: Metal organic frameworks, Membrane material, Electrospinning, Air cleaning Acknowledgements: Financial support was provided by the National Natural Science Foundation of China ( , U ), the National Key R&D program (2016YFC ) and the Jiangsu Outstanding Youth Fund Project (BK ).

141 Jw (L m -2 h -1 ) Janus Membrane with Unparalleled Forward Osmosis Performance Shenghua Zhou 1, Fu Liu*, Jianqiang Wang, Haibo Lin, Qiu Han, Shuaifei Zhao* 2 and Chuyang Y. Tang 3 1 Key Laboratory of Marine Materials and Related Technologies, Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, No Zhongguan West Rd, Ningbo, , China. 2 Department of Environmental Sciences, Macquarie University, Sydney, NSW 2109, Australia 3 Department of Civil Engineering, The University of Hong Kong, Pokfulam Road, , Hong Kong, S.A.R., PR China We report the use of porous Janus membranes for forward osmosis (FO). A porous Janus FO membrane, comprised of a hydrophilic cellulose acetate layer and a hydrophobic polyvinylidene fluoride (PVDF) nanofiber layer, was fabricated by electrospinning. The resultant membrane exhibited outstanding FO performance, with high water flux of L m 2 h 1 and a low reverse salt flux of 1.65 g m -2 h -1 using 1 M NaCl draw solution. Different from the state-of-the-art thin film composite (TFC) membranes, the prepared Janus membrane demonstrates unparalleled FO performance via a nanofluidic diode model, whose high selectivity is determined by the air gap within the hydrophobic nanofiber layer that can effectively prevent the reverse salt diffusion. Wetting of the hydrophobic layer is the crucial issue in Janus FO membranes, which deserves further attention to extend the osmosis longevity This Work Jw/Js (L g -1 ) Key Words: Porous Janus membranes, Forward osmosis, Air gap, Nanofluidic diode Acknowledgements: Financial support is acknowledged from National Natural Science Foundation of China ( , ), Ningbo Science and Technology Bureau (2014B81004, 2017C110034). The authors also acknowledge the partial financial support from the NSFC/RGC Joint Research Scheme sponsored by the Research Grants Council of Hong Kong and the National Natural Science Foundation of China (N_HKU706/16). [1] Shenghua Zhou, Fu Liu*, Jianqiang Wang, Haibo Lin, Qiu Han, Shuaifei Zhao* and Chuyang Y. Tang, Janus membrane with unparalleled forward osmosis performance, Environ. Sci. Technol. Lett., 2019, 6, [2] Shenghua Zhou, Zhu Xiong, Fu Liu*, Haibo Lin, Jianqiang Wang, Tiantian Li, Qiu Han and Qile Fang, Novel Janus Membrane with Unprecedented Osmosis Transport Performance, Journal of Materials Chemistry A, 2019, 7, [3] Tiantian Li, Fu Liu*, Shaofei Zhang, Haibo Lin, Jianqiang Wang, Janus PVDF membrane with extremely opposite wetting surfaces via one single step unidirectional segregation strategy, ACS Applied Materials & Interfaces, 2018,10 (29),

142 Superwetting nanofibrous membrane for oil/water separation: mechanism and applications Jianqiang Wang 1,2 and Fu Liu 1,2 1 Ningbo Institute of Material Technology & Engineering, Chinese Academy of Sciences, Zhongguan West Road 1219#, Ningbo, , China. 2 University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing, 10049, China Nanofibrous membranes obtained through electrospun method have been widely used in the fields of environmental engineering and separations due to their unique properties of high porosity, large surface area and controllable structure [1]. Especially, nanofibrous membranes have been considered as exceptional candidates for oil/water treatment because of their intrinsic microstructure obtained by the random assembling of nanofibers and super-low mass transfer resistance [2]. However, separation mechanism of nanofibrous membrane for oil/water separation is rarely discussed as well as the antifouling properties. In this presentation, except for the construction of superwetting nanofibrous membrane, we will endeavor to illustrate the separation mechanism of nanofibrous membrane for emulsions. In addition, antifouling properties of the nanofibrous membrane was significantly enhanced through the manipulation surface chemistry and separation process. The fabricated nanofibrous membranes exhibited long-term stability for separation of emulsions. Separation performance and the proposed mechanism were presented in Figure 1. Fig. 1 Separation performance and the proposed separation mechanism. Key Words: Nanofibrous membrane; Superwetting; Antifouling; Oil/water; Separation. : [1] Y. Liao, C.-H. Loh, M. Tian, R. Wang and A.G. Fane, Progress in electrospun polymeric nanofibrous membranes for water treatment: fabrication, modification and applications [J]. Prog. Polym. Sci., 2018,77, [2] X. Wang, J. Yu, G. Sun and B. Ding, Electrospun nanofibrous materials: a versatile medium for effective oil/water separation [J]. Mater. Today, 2016, 19,

143 Nanofibrous membrane design for antifouling distillation towards water desalination Wei Wang * State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin , China. Facing the global water scarcity, interfacial distillation working on interconnected porous membranes is attracting ever-growing attention in research and application. It excels itself in the ability of treating high-salinity brines, employing low-grade waste-heat energy, highly compact configuration, etc., when compared with other desalination methods. Electrospun products providing high porosity and low pore tortuosity thus is promising to facilitate mass transfer and then increase water flux. In this presentation, we will review our current work on nanofibrous membrane design to achieve antifouling/antiwetting distillation towards seawater and wastewater desalination. For practical application during distillation desalination, hydrophilic and hydrophobic organic pollutants frequently coexist with inorganic salts, which will cause membrane wetting and membrane fouling, respectively. We rationally designed omniphobic and super-hydrophilic/super-hydrophobic Janus fibrous membrane evaporators to solve the above two handcuffs. Besides, we also pay attention to membrane design and modulation to overcome salt-scaling during desalination. Key Words: (membrane distillation, water desalination, water treatment, electrospinning, nanofibrous membrane) [1] Zhu Z, Liu Y, Wang W, et al. Dual-Bioinspired Design for Constructing Membranes with Superhydrophobicity for Direct Contact Membrane Distillation [J]. Environ. Sci. Technol., 2018, 52: [2] Deshmukh A, Boo Chanhee, Karanikol V, Membrane distillation at the water-energy nexus: limits, opportunities, and challenges [J]. Energy Environ. Sci., 2018, 11 :

144 Waste cigarette filter as nanofibrous membranes for on-demand immiscible oil/water mixtures and emulsions separation Weimin Liu 1, Guorong Zhua 1, Lan Luoa 1, Mouji Lia 1, Jian Li *,1 College of Chemistry and Chemical Engineering, Northwest Normal University, Gansu International Scientific and Technological Cooperation Base of Water-retention Chemical Functional Materials, Research Center of Gansu Military and Civilian Integration Advanced Structural Materials, Lanzhou , P. R. China. The rapid industrial growth and the frequent oil spill accidents have led to the large production of oily wastewater. Thus, it is urging to develop a low-cost and eco-friendly material to purify the oily wastewater. In our work, the waste cigarette filter as the raw material was used to prepare cigarette filter coated meshes (CFCMs) by a facile electrospinning approach. The as-prepared CFCMs prewetted with water or oil achieved the special wetting performance of underwater superoleophobicity or underoil superhydrophobicity without any further chemical modification. Hence, the cigarette filter coated meshes with larger or smaller pore size can be applied to on-demand immiscible oil/water mixtures (light or heavy oil/water mixtures) and oil/water emulsions separation (water-in-oil or oil-in-water emulsions), respectively. Moreover, the CFCMs still exhibited high separation efficiency larger than 99.9 % for immiscible oil/water mixtures and emulsions after many cyclic testing. The work provides an application in oil/water separation for waste cigarette filters and contributes to reduce the pollution for environment from the waste cigarette filters. Key Words: electrospinning; underwater superoleophobicity; underoil superhydrophobicity; ondemand; oil/water separation Acknowledgements: This project was funded by the National Natural Science Foundation of China (no ), the Fok Ying-Tong Education Foundation of China (161044), the Natural Science Foundation for Distinguished Young Scholars of Gansu Province, China (18JR3RA083), China Postdoctoral Science Foundation (2018T110025, 2017M610031), and the Yong Teacher Research Group Foundation of Northwest Normal University (NWNU-LKQN-16-6). [1] Weimin Liu, Mengke Cui, et al. Waste Cigarette Filter as Nanofibrous Membranes for On- Demand Immiscible Oil/water Mixtures and Emulsions Separation [J]. J Colloid Interface Sci,2019, 549:

145 4. Post 4.1 Nanofiber for medical and biology

146 An electrospun membrane with wound healing and scar healing function Changming Su, Xianrui Xie, Guige Hou*, and Chunhua Wang* School of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, , P. R. China. Abstract: Scar is a difficulty in treatment of trauma, postoperation and burn. Excessive growth rate of scar can protrude the skin, which could bring itches and pains to patients. Effective repair of scars is significant for patients. In the situation, many well-known pharmaceutical companies have dedicated to development of new scar repair materials at home and abroad. At present, preparations of scar healing with polydimethylsiloxane gel occupy the market. But the fly in the ointment is that expensive imports, frequent inflammation, overlong treatment, pricking sensation of skin etc. In recent years, the electrospinning nanofilm possess excellent characteristic of promoting cell adhesion, proliferation and resisting the invasion of bacteria in process of wound healing and scar healing. In the previous study, self-developed medical antibacterial materials (A), polycaprolactone (PCL), collagen (COL) were used to developing wound scaffolds (PCA), which exhibit good function about hemostasis, antibacteria, anti-inflammation and wound healing. However, the PCA of scar healing function was absent in process of wound healing. In this study, self-developed polymethylhydrosiloxane gel (B) and PCA will be combined and developed to an electrospun nanofiber (PCAB) with multifunction of healing wound and scars. The PCAB not only remedies defect of commercially available polydimethylsiloxane gel, but also achieves wound hemostasis, wound healing, scar healing and other functions. Key words: Electrospinning, silicone gel, scar repair, wound repair, anti-inflammatory Acknowledgements: Foundation of Shandong province (No.2015GGX102013), Foundation of Yantai city (No.2018XSCCO48). : 1. Tan GZ, Zhou Y. Tunable 3D nanofiber architecture of polycaprolactone by divergence electrospinning for potential tissue engineering applications [J]. Nano-Micro Lett, 2018, 10(4): Xie X R, Li D S, Su C M, et al. Functionalized biomimetic composite nanfibrous scaffolds with antibacterial and hemostatic efficacy for facilitating wound healing [J]. J Biomed Nanotechnol, 2019,15, doi: /jbn

147 Atorvastatin calcium Loaded Poly(LLA-CL) Nanofiber Covered Stent- Graft Chu Jin, Mo Xiumei* Collage of Chemistry, Chemical Engineering and Biotechnology, Donghua University, China * Introduction Restenosis caused by thrombopoiesis is one of the biggest hinders of endovascular stent-graft used in small-diameter vessels. In this study, we explored a new type of stent-graft covered with atorvastatin calcium loaded into the core of poly(l-lactide-co-caprolactone) nanofibers via emulsion electrospinning for treating aneurysms. Materials & Methods Emulsion of P(LLA-CL) containing Atorvastatin calcium was prepared by 0.5ml mixed aqueous solution with gradient concentration of Atorvastatin calcium, and span80 in dichloromethane, and formed the uniform waterin-oil emulsion via magnetic stirring. And some hours later, added P(LLA- CL) in emulsions and the mixture was stirred one night to obtain uniform electrospinning solution. Finally the solution was electrospun to obtain scaffold contained gradient concentration of Atorvastatin calcium. Similarly, emulsion of P(LLA-CL) PBS group was prepared by the same method without adding Atorvastatin calcium. The electrospun scaffolds were prepared by electrospinning and named as PLCL-Atv and PLCL-PBS. Results & Discussion Figure 1 SEM images of electrospun nanofibers. A. PLCL-Atv B. PLCL-PBS C.PLCL. The nanofiber scaffold based on P(LLA-CL) with Atorvastatin calcium encapsulated groups and PBS group were fabricated by emulsion electrospinning. And pure P(LLA-CL) nanofibers were fabricated by general electrospinning. Figure 1 shows the nanofiber in the scaffolds was continuous and beadless. There is no significant difference in diameter of PLCL-Atv, PLCL-PBS and pure PLCL nanofibers. Figure 2 A. FTIR images of PLCL, Atv, PLCL-Atv(KBr), PLCL-Atv(ATR) B. TEM images of electrospun nanofibers PLCL-Atv The TEM images in Fig. 2.B show that the nanofibers showed a core shellstructure. The FTIR spectra of four different samples are shown in Fig. 2.A. By comparing PLCL-Atv(ATR) with pure PLCL, there was no significant difference between them in terms of their FTIR spectra. PLCL- Atv(KBr) has typical absorption peak of Atorvastatin (1620 cm 1 caused by COOH stretching of NH group). This result demonstrated that Atorvastatin had been incorporated into the fibers. Conclusion In this study, PLCL-Atv nanofibers were fabricated and coated on the stent successfully. the nanofiber in the scaffolds was continuous, smooth, and beadless. And Atorvastatin calcium had been incorporated into the fibers.the new type of nanofiber can promote HUVEC proliferation and adhesion in vitro. These study showed the potential of Atorvastatin calcium loaded nanofibers fabricated by emulsion electrospinning.

148 Tilapia Skin Collagen based Bi-layered Electrospun Membrane for Guided Tissue Regeneration Inspired by Prodrug of Pharmacochemistry Dongsheng Li 1, Yonglin Gao 2, Yunzhi Wang 2, Ruoxin Chen 1, Chuanglong He 1, and Xiumei Mo 1 1 College of Chemistry, Chemical Engineering and Biotechnology,Donghua University, Shanghai, P.O.Box , China. 2 College of Life Sciences, Yantai University, P.O.Box , Yantai, China. Guided tissue regeneration (GTR) is a frequently used and necessary technology in the periodontal surgery. During the treatment of periodontitis or tooth loss, the application of GTR membrane is indispensable 1. In this study, we designed and prepared a tilapia skin collagen based bi-layered electrospun membrane (TC-BEM) inspired by PRODRUG, which has the dense-layer A and the potential loose-layer AB. Firstly, the electrospinning solution A was prepared by mixing tilapia skin collagen and L-PLGA at the radio of 40:60, while the electrospinning solution B was prepared by pure tilapia skin collagen. The two solutions were simultaneously electrospun and received by a rotating cylinder. The resulting membrane was called AB. Then solution A continued to be used for electrospinning to fabricate a layer of film on top of the AB, and then the bi-layered AB/A was obtained(fig. 1 A). AB/A was placed into saline at 37 for 7 days, and observed by scanning electron microscopy(sem) after freeze-dried pretreatment. For cytocompatibility of TC-BEM, L929 cells were inoculated onto layer A, while MC3T3-E1 cells were inoculated onto layer AB, cell morphology was observed by SEM 3 days later, and cell growth was observed by H&E staining 8 days later. The results showed that both sides of TC-BEM were composed of nano-fiber structure(fig. 1 B-a, b), while the pore size of the AB layer significantly increased after the treatment with saline(fig. 1 B-c, d), which might be caused by the degradation of fish collagen nanofibers. Cell experiments showed that L929 cells adhered well in layer A and only grew on the surface of the layer(fig. 1 B-e, g), while MC3T3- E1 cells spread well in layer AB and could grow into the layer AB(Fig. 1 B-f, h). TC-BEM would be a strongly promising biomaterial for GTR. Key Words: GTR, Tilapia skin collagen, Bi-layered electrospun membrane, Prodrug Acknowledgements: National Major Research Program of China (2016YFA ). [1] Marco C. Bottino, Vinoy Thomas, Gudrun Schmidt, et al. Recent advances in the development of GTR/GBR membranes for periodontal regeneration A materials perspective [J]. Dental materials, 2012, 28: [2] Meifei Lian, Binbin Sun, Zhiguang Qiao, et al. Bi-layered electrospun nanofibrous membrane with osteogenic and antibacterial properties for guided bone regeneration [J]. Colloids and Surfaces B: Biointerfaces, 2019, 176: Fig. 1 (A) Schematic illustration of the process. (B) Characterization and cytocompatibility of TC-BEM. SEM of layer A(a) and layer AB(b); SEM of layer A(c) and layer AB(d) placed into saline at 37 for 7 days; proliferation of L929 being cultured on layer A for 3d(e) and proliferation of MC3T3-E1 being cultured on layer AB for 3d(f); H&E staining of TC-BEM after seeding L929 on layer A for 8d(g) and after seeding MC3T3-E1 on layer AB for 8d(h).

149 Genipin crosslinked hydrogel from the decellularized dermal extracellular matrix Fan Yu 1, Jinglei Wu 1, Xiumei Mo 1* 1.State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, , P. R. China, * Introduction The decellularized extracellular matrix is a novel natural biomaterial that is widely investigated for tissue reconstruction. Recently, it has been processed into a soluble form and used as injectable hydrogel, which is advantageous for the filling of irregularly shaped defects[1]. Genipin reacts with amine groups of proteins and other compounds to produce hydrogels[2]. Herein, we propose to determine the injectability and structure of genipin crosslinked hydrogels derived from the decellularized porcine dermis. Keywords: decellularization, hydrogel, genipin, dermis Methods The decellularized dermal extracellular matrix (ddecm) was prepared from porcine dermis as previously described[1]. Briefly, full thickness skin was harvested from pigs. Mechanical delamination was taken to remove redundant tissues. The samples were cut into slices and subjected to following treatments: trypsin for 6h, ethanol for 10h, EDTA/Tris in Triton for 6h and refreshed for 16h, peracetic acid/ethanol for 2h. The obtained ddecm was lyophilized. The ddecm powders were solubilized by pepsin/hcl. The solution was cooled to 4, then NaOH and PBS successively were added to form pre-gels. Genipin with varied concentrations was added to pre-gels,then incubated at 37. Results and Discussion The ddecm pre-gels showed good injectability, which could be loaded with syringe. The freeze-drying sample of ddecm hydrogel showed nano-fibrous morphology with randomly oriented fibrils. The ddecm hydrogels were obtained by crosslinking from 8mg/ml matrix solution with 0,0.5,1 and 2mM for 24h. The opaque hydrogels turned blue gradually with genipin concentration increased. Figure 1 The ddecm solution was loaded into a syringe and injected through a needle Figure 2 The SEM of freeze-drying sample of ddecm hydrogel Figure 3 The ddecm hydrogels crosslinked by genipin (0, 0.5, 1 and 2mM) Conclusion The ddecm can be processed into flowable solution that is suitable for injection and form solid hydrogels in situ under physiological condition. The ddecm hydrogel retains nanofibrous structure. Genipin of varied concentration doesn t affect the gelation of ddecm solution apparently. The ddecm has the potential to be used in tissue engineering application [1] Wolf, M.T., et al., A hydrogel derived from decellularized dermal extracellular matrix. Biomaterials, (29): p [2] Jeffords, M.E., et al., Tailoring material properties of cardiac matrix hydrogels to induce endothelial differentiation of human mesenchymal stem cells. ACS applied materials& interfaces, (20): p

150 Preparation and biological characterization of polyhydroxyfatty acid ester/sodium alginate electrospun nanofibers Fanchen Sun 1, Jing Guo 1,2, Yue Yu 1,2, Sen Zhang 1,2. 1.School of Textiles and Materials Engineering,Dalian Polytechnic University, Dalian. P.O.Box , China, 2. Liaoning Engineering Fiber and Composite Materials Engineering Center, Dalian. P.O.Box , China. Summary: Polyhydroxyalkanoate (P(3HB-co-4HB)) are candidate biomaterials due to their good strength properties, excellent biodegradability and biocompatibility [1]. However, P(3HB-co-4HB) need to have tunable hydrophilicity to expand their therapeutic applications due to the lack of polar groups in its structure, which has a certain effect on cell proliferation. To make up for its shortcomings, hydrophilic sodium alginate (SA), which are favorable for cell adhesion, proliferation and differentiation, was selected as the modifier in this study [2]. P (3HB-co-4HB) /SA nanofiber membrane was prepared by electrospinning. Alkyl Polyglycoside (APG) acted as an emulsifying agent, which had the double task of promoting the emulsification and of stabilizing the blending solution of P (3HB-co-4HB) and SA. When the SA concentration was 6%, uniform morphology with an average diameter of 500 nm and a porosity of 74% were obtained. The fraction of the extracts of the P (3HBco-4HB)/SA nanofiber membranes were more than 100%, both of which were grade 0. Those blending nanofiber membranes are more favorable for cell adhesion, growth and compatibility, with the increasing of the content of SA. It has potential application for biomaterials without cytotoxicity. Fig.1 Experimental process and analysis of co-dissolution mechanism Key words: Polyhydroxyalkanoate, sodium alginate, nanofibers, biocompatibility, electrospinning [1]Leong YH, Isa ASM, Mohamed MM. Acute and repeated dose 28-day oral toxicity of poly(3- hydroxybutrate-co-4- hydroxybutrate) nanoparticles in Sprague-Daweley rates. Regulatory Toxicology.2018,95: [2]Ao Z, lingyan C, Yang L. Biocompatible silk/calcium silicate/sodium alginate composite scaffoids for bone tissue engineering. Carbohydrate Polymers :

151 Nanocarrier-Loaded Electrospun Hierarchically Structured Fibers for Cancer Therapy Guang Yang 1, Xilin Li 2, Yang He 2, and Shaobing Zhou 1, 2 1 College of Medicine, Southwest Jiaotong University, Chengdu , Sichuan, PR China. 2 Key Laboratory of Advanced Technologies of Material, Minister of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu , P. R. China. Introduction Through careful adjusting of the electrospinning parameters, electrospun polymeric fibers with various interesting and tunable hierarchically structures can be fabricated, such as beaded fibers, bamboo-like fibers, core-shell fibers and so on. These well-defined hierarchically structured polymer fibers enable the fibers to be used more effectively in applications in the biomedical field, such as drug delivery, tissue engineering, and diagnostics [1]. Research Design Our groups have developed fibers with different multilevel structures by loading nanocarriers (e.g. micelles [2-4] and polydopamine nanoparticles) into electrospun fibers via uniaxial blend electrospinning [2], coaxial electrospinning [3], microfluidic electrospinning [4], as localized anticancer implants. Main Results and Discussion According to the results of in vivo anticancer studies, in contrast to the systematic administration of therapeutics via repeatedly intravenous injections of micelles, all the implantable micelles-in-nanofiber devices have the capacities of greatly reducing the drug dose, the frequency of administration and side effect of chemotherapeutic agents while maintaining highly therapeutic efficacy against artificial solid tumors [3, 4]. What s more, when properly introduced dual drugs, a programmable release model with a rapid release of the doxorubicin-loaded micelles while a slow release of apatinib, would be achieved, which showed an excellent antitumor effect on multiple drug resistance tumor-bearing mice [4]. Conclusion These studies opens a wide range of new possibilities for the development of multifunctional implantable devices for effective and safe cancer therapy. Scheme 1. Nanocarrier-loaded hierarchically structured nanofiber implants for localized anticancer therapy. Key Words: electrospinning, hierarchical structures, localized cancer therapy, programmable release Acknowledgements: This work was partially supported by the National NaturalScience Foundation of China ( ), and the Fundamental Research Funds for the Central Universities( CX040). [1] Guang Y, Xilin L,Yang H, et al. From Nano to Micro to Macro: Electrospun Hierarchically Structured Polymeric Fibers for Biomedical Applications [J]. Progress in Polymer Science, 2018, 81: [2] Guang Y, Jie W, Long L, et al. Electrospun Micelles/Drug-Loaded Nanofibers for Time- Programmed Multi-Agent Release [J]. Macromolecular bioscience, 2014, 14(7): [3] Guang Y, Jie W, Yi W, et al. An Implantable Active-Targeting Micelle-in-Nanofiber Device for Efficient and Safe Cancer Therapy [J]. ACS Nano, 2015, 9(2): [4] Yang H, Xilin L, Junkai M, et al. Programmable Codelivery of Doxorubicin and Apatinib Using an Implantable Hierarchical-Structured Fiber Device for Overcoming Cancer Multidrug Resistance[J]. Small, 2019, 15(8):

152 Electrospun bilayer composite vascular graft with an inner layer modified by PEG and Haparin to regenerate the blood vessel Haizhu Kuang 1, Peng Zhang 1,* 1 Shenzhen Luohu People s Hospital, Shenzhen , Guangdong, China. com (Haizhu Kuang ); (Peng Zhang) The implantation of small-caliber blood vessels often fails and embolization often occurs after a vascular graft is transplanted into the body, as it cannot rapidly endothelialize. 1-2 Restenosis and embolization are two hurdles result from small caliber artificial blood vessels in clinical practice, and the problems cannot be sufficiently resolved. In this study, we prepared a composite vascular graft with two layers. The inner layer, which was comprised of degradable Poly (lactic-co-glycolic acid) (PLGA)/Collagen (PC) nanofibers modified by mesoporous silica nanoparticles (MSN), was grafted with polyethylene glycol (PEG) and heparin to promote cell proliferation and to improve blood compatibility. The outer layer was comprised of polyurethane (PU) nanofibers in order to provide mechanical support. The process for the preparation of the PC/ MSN-PEG-Heparin fiber had been showed in Figure.1A. The inner layer did not cause an inflammatory reaction during the degradation process in vivo and there was uniform cellular growth on the PC/ MSN-PEG-Heparin fiber membrane. Composite grafts implanted into the rabbit carotid artery were evaluated for 8 weeks by H&E and immunohistochemical staining, demonstrating that a monolayer of endothelium (CD31-labeled) and smooth muscle (αsmalabeled) regenerated on the composite graft (Figure.1B). Our results demonstrate that the composite graft, with a functional inner layer, has potential to be used for small-caliber blood vessels with longterm patency. Figure 1A. The process of fabricating the PC/ MSN-PEG-Hep fiber, Figure.1B Immunohistochemistry of endothelial cells and smooth muscle cells. DAPI (blue), CD-31 and αsma (green). Key words: PEG, heparin, electrospinning, artificial vascular graft, biocompatibility. [1] He W, Hu Z, Xu A, et al. The preparation and performance of a new polyurethane vascular prosthesis. Cell Biochem Biophys. 2013,66(3): [2] Peck M, Gebhart D, Dusserre N, Mcallister TN, L'Heureux N. The evolution of vascular tissue engineering and current state of the art. Cells Tissues Organs. 2011,195(1-2):

153 A Crosslinking Strategy to Make Neutral Polysaccharide Nanofibers Robust and Biocompatible Hui Zhang, Junli Hu*, and Yichun Liu Key Laboratory of UV-Emitting Materials and Technology (Northeast Normal University), Ministry of Education, P.O.Box Changchun, Jilin, China. Nanofibers of neutral polysaccharides hold great potential for biomedical applications thanks to their abundancy and unique property. However, they are seldom applied in biomedicine due to the lack of crosslinking method. In this work, we report a periodate oxidation - adipic acid dihydrazide (ADH) crosslinking strategy to prepare robust and biocompatible neutral polysaccharide nanofibers. Neutral polysaccharides with adjacent dihydroxyl groups in saccharide residues are firstly partially oxidized with periodate to give dialdehyde polysaccharides. The electrospun nanofibers of dialdehyde polysaccharides are then crosslinked with ADH to form Schiff base crosslinkers between the polysaccharide chains. [1,2] With konjac glucomannan (KGM) as a representative, we found that compared with the traditional glutaraldehyde crosslinking strategy, the periodate oxidation-adh crosslinking strategy is more effective. As a result, the KGM nanofibers prepared with periodate oxidation-adh crosslinking strategy exhibited markedly higher water resistance. Moreover, due to the low toxicity of ADH, the KGM nanofibers prepared with periodate oxidation-adh crosslinking strategy exhibited better cytocompatibility. The strategy is versatile to other neutral polysaccharides such as starch and pullulan. These robust and biocompatible neutral polysaccharide nanofibers are expected to seek extensive applications in a variety of biomedical fields. Figure (a) Mass change and morphology profiles of various crosslinked KGM nanofibers incubated in simulated body fluid at 37 o C; (b) Viability of L929 fibroblast cells cultured with the leachates of various crosslinked KGM nanofibers. Key Words: neutral polysaccharide, nanofibers, crosslinking, water resistance, biocompatibility Acknowledgements: This work was supported by the National Natural Science Foundation of China (Nos , ). [1] Chen S N, Zhang H, Hu J L, et al. Cross-Linked Pectin Nanofibers with Enhanced Cell Adhesion. [J] Biomacromolecules, 2018, 19(2): [2] Li K, Cui S S, Hu J L, et al. Crosslinked Pectin Nanofibers with Well-Dispersed Ag Nanoparticles: Preparation and Characterization. [J] Carbohydrate Polymers, 2018, 199:

154 Chitosan/tannic acid bilayers layer-by-layer deposited cellulose nanofibrous mats for antibacterial application Jing Huang a,1, Jin Huang a,1, Yang Wu 1, Xiaowen Shi 1 and Hongbing Deng 1,* Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, Hubei Key Lab of Biomass Resource Chemistry and Environmental Biotechnology, School of Resource and Environmental Science, Wuhan University, Wuhan , China. In this study, cellulose mats, which were obtained via alkali hydrolysis of cellulose acetate electrospun mats, were modified by layer-by-layer self-assembly technology with chitosan and tannic acid to fabricate the composite mats. The testing results showed that the material possessed great fiber shape, three-dimensional structure, excellent antibacterial activity against Escherichia coli and Staphylococcus aureus, and that these technology was able to improve the surface characteristics, hydrophilicity and mechanical properties. The antibacterial activity of the mats against Staphylococcus aureus amounted to more than 99% and Escherichia coli to 86%. Therefore, the cellulose mats have excellent antibacterial activity and are expected to have considerable development potential in the field of food packaging or wound dressing. Key Words: Chitosan, Tannic acid, LBL, Cellulose nanofibrous mats, Antibacterial Acknowledgements: This work was supported by the National Key R&D Program of China (No. 2016YFB ) of China and National High Technology Research and Development Program of China (863 program, No. 2015AA020313), partially supported by the Natural Science Foundation of Hubei Province of China (Team Project, No.2015CFA017) and the Fundamental Research Funds for the Central Universities of China (No kf0175). : [1] Khanbabaee K and van Ree T, Tannins: Classification and Definition [J]. Natural Product Reports, 2001, 18(6): [2] Ejima H, Richardson J J, Liang K, et al. One-Step Assembly of Coordination Complexes for Versatile Film and Particle Engineering[J]. Science, 2013, 341(6142):

155 Construction of multi-channeled nerve conduit with shape memory nanofibers Jing Wang and Xiaoli Zhao 1 Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, P.R.China. Repair of large peripheral nerve gaps is one of the most important clinical problems. Autologous and allogenic nerve transplantation has various shortcomings. Tissue-engineered nerve conduits provide a new idea for the repair of long-distance nerve defects. Multi-channeled nerve conduits have attracted widespread attention because they can mimic natural nerves more structurally. Shape memory polymers as a kind of intelligent responsive materials provide a new method for the construction of tubular scaffold [1]. In this study, PLATMC as a shape memory polymer was introduced into the construction of multi-channeled nerve conduit. The rapid automatic formation of multi-channeled nerve conduit achieved using its thermo-responsive shape memory characteristics. First, double layers of nanofibers with random arrangement at the bottom and oriented arrangement at the top were prepared by electrospinning. Morphology, thermal and mechanical properties of the resultant nanofibers were characterized using different techniques. Then the nanofiber mat reshaped into a tube with a defined diameter by a template method in an oven (80 C), subsequently resulting in the PLATMC shape memory tube with an original tubular shape. Further, PLATMC tubes retained their temporary planar shapes at room temperature (25 C). After seeding of Schwann cells, the planar PLATMC nanofiber mat with temporary planar shapes was placed into culture medium at 37 C. As a result, with the shape memory property, the PLATMC nanofiber mat completely recovered their permanent tubular structures within several seconds. A large diameter tube wraps several small diameter tubes to construct a multi-channeled nerve conduit. Biological assay results corroborated that the shape memory nnaofibers of PLATMC were cytocompatible by supporting Schwann cells adhesion and proliferation. In conclusion, this approach is a promising strategy to construct nerve conduit for peripheral nerve regeneration. Figure 1. The DSC curves of fabricated PLATMC nanofibers and multi-channeled nerve conduits fabricated with shape memory nanofibers. Key Words: multichannel, nerve conduit, shape memory, nanofibers [1] Qilong Z, Juan W, Huanqing C, et al. Programmed Shape-Morphing Scaffolds Enabling Facile 3D Endothelialization [J]. Advanced Functional Materials, 2018, 28:

156 Surface Biofunctionalization of Electrospun Nanofiber Membrane with Multilayer Self-Assembly for Bone Regeneration Jing Zheng 1, Rui Shi 2, Liqun Zhang 1, and Yuri Lvov 3 1 Beijing Laboratory of Biomedical Materials and State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing , PR China. 2 Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing , PR China. 3 Biomedical Engineering Program, Louisiana Tech University, Ruston, Louisiana 71270, United States. Due to the significant role of the periosteum in bone regeneration, we hypothesized that using a specially engineered artificial periosteum could lead to an enhancement in osteogenesis in bone grafts. Herein, electrospun poly (ε-caprolactone) (PCL) nanofibers coated with multilayer nanoscale collagen/chondroitin sulfate has been devised as flexible, permeable and osteoinductive artificial periosteum (PCS membrane) using layer-by-layer self-assembly technique. The morphology, physical property and in vitro biomineralization performance of the PCS membrane were investigated. The quartz crystal microbalance(qcm) showed 10-bilayers of collagen/chondroitin sulfate has been successfully coated on electrospun PCL nanofibers. Furthermore, the as prepared biofunctionalized membrane demonstrated excellent capabilities to induce mineralization with the formation of hydroxyapatite layer on the surface of the nanofiber which could be beneficial for the enhanced osteoinduction. These results indicate the huge potential of this fibrous membrane with multiscale structure and favorable biological cues as a biomimetic artificial periosteum to accelerate bone regeneration. Key words: Electrospinning, Periosteum, Layer-by-layer self-assembly, Bone regeneration Acknowledgements: This work was supported by the Foundation for Innovative Research Group of the NSF of China ( ); National Natural Science Foundation of China (grant numbers , , ); Beijing Talent Fund (grant number ZK34), and the 13th five-year plan of the Beijing Municipal Commission of Health and Family Planning (PXM ). [1] Jang J H, Castano O, Kim H W. Electrospun materials as potential platforms for bone tissue engineering [J]. Advanced drug delivery reviews, 2009, 61(12): [2] Wang T, Zhai Y, Nuzzo M, et al. Layer-by-layer nanofiber-enabled engineering of biomimetic periosteum for bone repair and reconstruction [J]. Biomaterials, 2018, 182:

157 Crosslinked Pectin Nanofibers for Biomedical Applications Junli Hu, Yichun Liu Key Laboratory of UV-Emitting Materials and Technology (Northeast Normal University), Ministry of Education, Changchun , China. Pectin is a plant-soured polysaccharides with rich resources. It is biocompatible, biodegradable, and with rich bioactivities. Electrospun nanofibers share similar structure with natural extracellular matrix and have high specific surface area. Pectin nanofibers combine the advantages of pectin material and nanofibrous structure, holding great potential for biomedicine. We developed crosslinked pectin nanofibers with enhanced cell adhesion with a periodate oxidation adipic acid dihydrazide crosslinking strategy. The crosslinked pectin nanofibers can further be endowed with long-term antibacterial ability by incorporating Ag nanoparticles through in situ reduction. Figure 1. (A) Fluorescent images of the cells cultured on Ca 2+ crosslinked pectin nanofibers (Ca 2+ ) and pectin nanofibers crosslinked with periodate oxidation adipic acid dihydrazide crosslinking strategy (PO-ADH), and the illustration of the possible cell binding domains in PO-ADH crosslinked pectin nanofibers; (B) Cross-section TEM image of crosslinked pectin nanofibers with well-dispersed Ag nanoparticles, the release behavior of Ag and the long-term antibacterial effects. Key Words: pectin, nanofibers, cell adhesion, antibacterial Acknowledgements: This work was supported by the National Natural Science Foundation of China (No ) [1] Chen S, Cui S, Zhang H, et al. Cross-Linked Pectin Nanofibers with Enhanced Cell Adhesion [J]. Biomacromolecules, 2018, 19: [2] Li K, Cui S, Hu J, et al. Crosslinked Pectin Nanofibers with Well-Dispersed Ag Nanoparticles: Preparation and Characterization [J]. Carbohydr. Polym., 2018, 199:

158 Layered Nanofiber Sponge with an Improved Capacity for Promoting Blood Coagulation and Wound Healing Kexin Zhang, Zhipeng Yuan, Xiangyu Jiao, Yansheng Li, Yongqiang Wen* Research Center for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, P.O. Box Beijing , P. R. China. E- mail: Effective bleeding control and wound healing are very important and can be life saving. However, traditional wound dressings with structural deficiencies are not effective in controlling bleeding and promoting the regeneration of functional tissues. In this study, a three-dimensional (3D) layered nanofiber sponge was obtained by expanding two-dimensional (2D) nanofiber membranes into the third dimension. This sponge has a layered nanofiber structure, which increases the interfacial interaction between the sponge and blood cells to accelerate hemostasis. Through fine-tuning of structure, the 3D nanofiber sponge acquires properties beneficial to wound healing such as good elasticity and high permeability and fluid absorption ratio. The 3D nanofiber sponges are both highly compressible and resilient, providing tamponade for deep wounds and creating a good 3D dynamic microenvironment to regulate cellular behavior. Further research has demonstrated that the layered nanofiber structure could promote the regeneration of functional dermis and the restoration of differentiated adipocytes during the early repair phase. Experiments using model mice with fullthickness skin defects have shown that the layered nanofiber structure could effectively accelerate wound healing and reduce scar formation. This layered 3D nanofiber sponge design is easy to produce. Due to its excellent wound healing property, this porous nanofiber sponge has great potential for future clinical application as wound dressings. Fig. 1 Schematic showing the tamponade effect of the 3D nanofiber sponge in the full-thickness skin defect mouse model. Key Words: Layered nanofiber structure, Wound healing, Hemostasis, Elasticity Acknowledgements: The authors would like to thank Yan Qin,Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences. The authors would like to thank Beijing Natural Science Foundation ( ), National S&T Major Project of China (2018ZX ), the Fundamental Research Funds for the Central Universities and USTB. [1] J. Jiang, S. Chen, H. Wang, M.A, et al. CO2-expanded nanofiber scaffolds maintain activity of encapsulated bioactive materials and promote cellular infiltration and positive host response [J]. Acta biomater., 2017, 68: [2] A. J. Hassiba, M. E. El Zowalaty, G. K. Nasrallah, et al. Review of recent research on biomedical applications of electrospun polymer nanofibers for improved wound healing [J]. Nanomedicine, 2016, 11(6):

159 Preparation of Alum-Borneol-PVP Nanofibers Based on Alum-Borneol Nanoemulsion Libing Huang 1, Yong Liu 2 1 College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing , China. 2 College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing , China The traditional Chinese medicines, Alum is mainly composed of KAl(SO 4 ) 2 12H 2 O, which has the effects of astringent sores, hemostasis, etc. [1], Borneol has the effects of refreshing and refreshing, clearing away heat and relieving pain [2]. These two traditional Chinese medicines are often used in conjunction with each other, which has a good effect on treating burns and scalds. In 1975, the First Affiliated Hospital of Hunan University of Chinese Medicine used the Alum and Borneol to dissolve in water to prepare the Alum-Borneol solution, which was used to treat burns and scalds. The Alum- Borneol solution is suspension dosage form, which leads to its low bioavailability. Xiong et al. [3] used nanotechnology to prepare Alum-Borneol solution into Alum-Borneol nanoemulsion, which has a definite therapeutic effect on burn. As a drug carrier, nanoemulsion can improve the solubility of insoluble drugs. Inspired by Alum-Borneol nanoemulsion, we chose polyvinylpyrrolidone (PVP) as the carrier, prepared the mixed spinning solution by dissolving alum and Borneol in distilled water and anhydrous ethanol respectively, and then prepared the Alum-Borneol-PVP nanofibers by solution electrospinning technology. The prepared Alum-Borneol-PVP fibers were immersed in distilled water at 37, so that the fibers were dissolved in the solution. Ethylenediamine tetraacetic acid disodium salt titration was used to identify the Alum composition in the fibers, and the solution eventually changed from yellow to lavender red, which proved that the fiber did contain Alum. The Borneol composition in the fibers was identified by the reaction of vanillin with Borneol in concentrated sulfuric acid, and the solution eventually changed to rose red, which proved that the fiber did contain Borneol. The diameter and morphology of Alum-Borneol-PVP blend fibers were observed by scanning electron microscopy, and the Alum-Borneol-PVP fibers were analyzed by infrared spectroscopy. The SEM results showed that the surface of the Alum-Borneol-PVP blend fibers is smooth, which proved that there is no phase separation between Alum, Borneol and PVP. The infrared spectra shows that there was no chemical reaction among Alum, Borneol and PVP molecules. The prepared Alum-Borneol-PVP nanofibers are expected to become a new wound dressing, which is meaningful. Fig. 1 SEM image (a) and Infrared spectrum (b) of Alum-Borneol-PVP fibers; diagram (c) of the Alum content determined by EDTA titration Key Words: Alum, Borneol, Polyvinylpyrrolidone, Solution electrospinning, infrared spectroscopy Acknowledgements: Financial support from the National Natural Science Foundation of China ( ) is gratefully acknowledged. : [1]National Pharmacopoeia Commission, Pharmacopoeia of the People's Republic of China 2015 year ed., China Pharmaceutical Science and Technology Press, Beijing, 2015, pp [2]National Pharmacopoeia Commission, Pharmacopoeia of the People's Republic of China 2015 year ed., China Pharmaceutical Science and Technology Press, Beijing, 2015, pp [3] Xiong J Q, Liu L F, Yang C P, et al. The Influence of Alum-Borneol Nanoemulsion on NOTCH Target Gene Expression in Rabbit with Deep Ⅱ Degree Burn [J].Guid. J Tradit. Chin. Med. Pharm. 2017, 23(15):

160 Novel Electrospun Microtube Array Membrane-Double (MTAM-D) Based Capture Device for Efficient Endotoxin Removal Li-Wei Cheng 1, Chee Ho Chew 1,2, Wan-Ting Huang 2, Ko-Shao Chen 3, Mai-Szu Wu 4, and Chien-Chung Chen 1,2,5 * 1 Graduate Institute of Biomedical Materials & Tissue Engineering, Taipei Medical University, Xinyi District, 11031, Taipei, Taiwan; 2 MTAMTech corporation, 17th floor, 3rd Yuanqu street, Nangang District, 11503, Taipei, Taiwan 3 Department of Materials Engineering, Tatung University 4 School of Medicine, Taipei Medical University 5 The PhD Program for Translational Medicine, Taipei Medical University, Taipei, 11052, Taiwan; Introduction: There are several diseases caused by excessive number of specific molecule in blood stream. The effective removal of these target compounds is essential therapeutic treatment. Taking sepsis for example, too much of endotoxin in the blood stream will cause the fatal consequence if not removed in a timely fashion. Research Design: In this study, a novel polysulfone (PS) Microtube Array Membrane- Double (MTAM-D) was prepared via coaxial electrospinning and functionalized by coating with Polymyxin B (PMB), the endotoxin-binding compound. The physical and blood compatibility properties of resulting capturing device, coded as PS MTAM/Cap, were characterized and finally the endotoxin capturing capacity was measured and bench-marked with market leading product. Results: The results show, not only the PS MTAM/Cap possess excellent blood compatibility and adequate mechanical properties. More importantly, this device can effectively remove endotoxin either from plasma or whole blood, with superior removal efficiency than that of commercial leading product (85% vs. Discussion: This may well be attributed to the unique structural characteristics of MTAM-D, which provides larger surface/volume ratio that increasing the probability of endotoxin contacted and captured by the active PMB sites. In summary, with unique structure of MTAM-D, we ve successfully demonstrated its superior function of a target capturing device, and MTAM/Cap can be an efficient target compound removal platform for several diseases treatments. Keywords: MicroTube Array Membrane-Double (MTAM-D); Endotoxin; MTAM/Cap device : 1. Yang J.C, et al. Formation of highly aligned, single layered, hollow fibrous assemblies and the fabrication of large pieces of PLLA membranes, Macromolecular Materials and Engineering, Vol. 297(2) Feb. 2012, Ou K.L, et al. Membranes of epitaxial-like packed, super aligned electrospun micron hollow poly(l-lactic acid) (PLLA) fibers European Polymer Journal, Vol 47(5) May 2011,

161 Study of the release kinetics of active compounds from electrospun polymeric membranes PANTALEONE BRUNI 1, FABIO MARONI 1, ANGELA TARTAGLIA 1, MARCELLO LOCATELLI 1, FAUSTO CROCE 1 1 University G. d Annunzio of Chieti-Pescara; Department of Pharmacy; via dei Vestini 31, Chieti; Italy; In recent years polymeric materials are becoming increasingly popular in various technological applications, particularly in the field of biomaterials and biomedical devices. Objectives of this work consist in the realization of electrospun membranes ( mats ) made from polymeric biomaterials and the study of their behaviour as possible storage and drugs delivery. The electrospinning process has been optimized and an operating protocol, which was able to provide reproducibly mats containing active compounds, based on a blend of poly (D, L-lactide) (PDLLA) and poly (ethylene oxide) (PEO) (polyetilenoxide) with good morphological and functional characteristics, has been formulated. The drug release kinetics has been characterized by studying the behaviour of these membranes in an aqueous medium by utilizing two different methodologies: the first one determines the differential release of the drug over time and the second one evaluates the total amount of the compound released over time. The results show how all the samples have a fast initial release followed by a prolonged slow release over time. This work suggests a potential application of this type of electrospun membranes which could be usefully adopted as drug delivery systems. Key Words: electrospinning, polymer, drugs delivery : [1]. Cianci E., Trubiani O., Diomede F., Merciaro I., Meschini I., Bruni P., Croce F., Romano M. Immobilization and delivery of biologically active Lipoxin A4 using electrospinning technology. International Journal of Pharmaceutics, 2016, vol. 515; [2]. International Conference on Harmonisation of technical requirements for registration of pharmaceuticals for human use. Harmonised Tripartite Guideline: Validation of Analytical Procedures: Text and Methodology, ICH Q2(R1) [3]. Tiaan H., Osama B., Bert K. and Leon D., Release of Bacteriocins from Nanofibers Prepared with Combinations of Poly(D,L-lactide) (PDLLA) and Poly(Ethylene Oxide) (PEO) Molecular Sciences 2011,

162 Application of Electrospinning in Constructing Integrated Rapid Magnetic Anastomosis Artificial Vessels Peng Liu 1, 2, Lifei Yang 1, Junxi Xiang 1, 2* 1, 2*, Yi Lv 1 National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi an Jiaotong University, Xi'an , China 2 Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an ,China Artificial blood vessels constructed by electrospinning have shown great potential for clinical application [1]. However, similar to other artificial blood vessel products, electrospun artificial blood vessels also have defects such as long anastomosis time and easy stenosis of the anastomosis. Magnetic anastomosis [2] is a seamless line anastomosis technique developed rapidly in recent years. It has the advantages of small tissue damage, no suture residue, and no narrowing of the anastomosis. Therefore, this study combined with electrospinning and magnetic anastomosis technology to construct an integrated rapid anastomosis artificial blood vessel. In this paper, a W/O emulsion is prepared by a water-in-oil method, wherein the oil phase is a PCL chloroform (TCM) solution, and the aqueous phase is an aqueous solution of heparin and dextran (DEX). The core-shell PCL / (Heparin + DEX) nanofibers were prepared by electrospinning, and the artificial blood vessel inner layer was prepared through a cylindrical receiver. A vascular anastomosis magnetic ring made of NdFeB is applied to both ends of the inner layer of the blood vessel, and a part of the inner blood vessel layer of both ends is folded to wrap the magnetic ring. The outer portion of the artificial blood vessel was then spun using a PCL/(TCM+DMF) solution. The results show that the artificial blood vessel has good microscopic morphology and blood compatibility. The mechanical properties and in vitro perfusion experiments show that the mechanical properties can meet the requirements of artificial blood vessels. This artificial blood vessel is an ideal vascular substitute with great clinical application value. Key Words: emulsion electrospinning, magnetic anastomosis, rapid anastomosis, artificial blood vessel [1] Ercolani E, Gaudio C D, Bianco A. Vascular tissue engineering of small-diameter blood vessels: reviewing the electrospinning approach[j]. Journal of Tissue Engineering and Regenerative Medicine. 2015, 9(8): [2] Graves C E, Co C, Hsi R S, et al. Magnetic Compression Anastomosis (Magnamosis): First-In- Human Trial[J]. Journal of The American College of Surgeons. 2017, 225(5).

163 Preparation and Characterization of Propolis/Antibacterial Peptide Fiber Membranes Saisai Wang 1, Xiaoming Cui 1, Zhilu Xu 1, Menghao Sun 2, Wentong Li 3, Xiuwen Guan 1, and Weifen Zhang 1,4,5,6* 1 School of Pharmacy, Weifang Medical University, Weifang , Shandong, P.R. China. 2 School of Clinical Medicine, Shanghai Jiao Tong University, Shanghai , Shanghai, P.R. China. 3 Department of Pathology, Weifang Medical University, Weifang , Shandong, P.R. China; 4 Collaborative Innovation Center for Target Drug Delivery System, Weifang Medical University, Weifang , Shandong, P.R. China. 5 Institute for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang , Shandong, P.R. China. 6 Shandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang , Shandong, P.R. China. Nowadays antibacterial protection is a necessary prerequisite for efficient wound healing and bacterial infections are gradually endangering people's health, the increase of bacterial drug resistance has been considered to be a serious global problem which urgently needs us to solve [1]. Propolis has the excellent antibacterial properties due to its different constituents such as flavonoids and cinnamic acid derivative [2]. Antibacterial peptide has excellent antibacterial ability, broad antibacterial spectrum and unique bactericidal mechanism which make it can avoid drug resistance, protect allergic skin and promote repair of damaged skin. Therefore, in our study, propolis/antibacterial peptide/polycaprolactone (PCL) fiber membranes were prepared by electrospinning method. Scanning electron microscopy (SEM) showed PCL nanofibers were smooth, uniform and well-defined. After adding to propolis, it was observed that there was point-bonded structure and the diameter of fibers was increased. However, fibrous morphology changed and appeared fiber adhesion and collapse after adding to antibacterial peptide. This will be further optimized. These fiber membranes provided a good prospect for the application of antibacterial and wound healing. Figure A. Electrospinning device Figure B. SEM images of nanofibers (a: PCL nanofibers; b: PCL/propolis nanofibers; c: PCL/antibacterial peptide nanofibers; d: PCL/propolis/antibacterial peptide nanofibers; PCL: 80 KDa, 10% (w/v), propolis: 30% (w/v), antibacterial peptide: 0.3% (w/v)) Key Words: Electrospinning, Propolis, Antibacterial Peptide, Antibacterial Acknowledgements: The authors are grateful for the generous financial support from National Natural Science Foundation of China (No ), National Key Technology R&D Program of the Ministry of Science and Technology (No. 2013GA740103). [1] Hinojos-Márquez E A, López-Esparza J, Espinosa-Cristóbal L F, et al. Antimicrobial Activity of Silver Nanoparticles in Polycaprolactone Nanofibers against Gram-Positive and Gram-Negative Bacteria [J]. Ind Eng Chem Res, 2016, 55(49): [2] Kim J I, Pant H R, Sim H J, et al. Electrospun propolis/polyurethane composite nanofibers for biomedical applications [J]. Mater Sci Eng C Mater Biol Appl, 2014, 44:

164 A Modified Wound Coil Collector for Fabrication of Quercetin-Loaded Tubular Scaffold for Neural Repair. Se Rim Jang 1, Chan Hee Park 1,2,* and Cheol Sang Kim 1,2,* 1 Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju , Republic of Korea 2 Division of Mechanical Design Engineering, College of Engineering, Chonbuk National University, Jeonju , Republic of Korea (S.R.Jang) The most important aspect of the scaffold made for nerve regeneration is to mimic ECM structures. So many studies continuously efforts to make more biocompatible and functional nerve conduit[1]. Quercetin found in may fruits, vegetables, and grains and pharmacological studies have demonstrated that it has effect on neuroprotective effects[2, 3]. In this study, we designed a tubular scaffold with random and aligned nanofibers by modified wound coil collector. This structure could overcome some of the limitations of conventional nerve transplantation. It helps to penetrate nutrients, neurotrophic factors, and oxygen. The scaffold has microscale topological that effect on neurite outgrowth and cell proliferation. The designed scaffold was analyzed by FE-SEM, FT-IR, FFT, XRD, CCK-8 assay and evaluated the changes in cell morphology. Consequently, this study developed quercetin-loaded tubular scaffold and it showed great benefits for neuronal cell proliferation. Key Words: Electrospinning, Nanofibers, Quercetin, Nanofibrous tube [1] B.S. Jha, R.J. Colello, J.R. Bowman, S.A. Sell, K.D. Lee, J.W. Bigbee, G.L. Bowlin, W.N. Chow, B.E. Mathern, D.G. Simpson, Two pole air gap electrospinning: Fabrication of highly aligned, threedimensional scaffolds for nerve reconstruction, Acta Biomater 7(1) (2011) [2] A. Klimaszewska-Wisniewska, M. Halas-Wisniewska, M. Izdebska, M. Gagat, A. Grzanka, D. Grzanka, Antiproliferative and antimetastatic action of quercetin on A549 non-small cell lung cancer cells through its effect on the cytoskeleton, Acta Histochem 119(2) (2017) [3] E.J. Yang, G.S. Kim, J.A. Kim, K.S. Song, Protective effects of onion-derived quercetin on glutamate-mediated hippocampal neuronal cell death, Pharmacogn Mag 9(36) (2013)

165 Fabrication of Three-dimensional fibrous scaffold and evaluation of applicability to bone tissue regeneration Sunny Lee 1, Mahesh Kumar Joshi 2, Chan Hee Park 1,3* and Cheol Sang Kim 1,3* 1 Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju , Republic of Korea. 2 Department of Chemistry, Tri-Chandra Mlutiple Campus, Tribhuvan University, Kathmandu, Nepal 3 Divison of Mechanical Design Engineering Chonbuk National University, Jeonju , Republic of Korea. Since the nanofiber is similar structure to extracellular matrix(ecm), there are various studies on tissue engineering applications using nanofibers produced by electrospinning. But conventional electrospinning methods can only make two-dimensional(2d) mats. To overcome this limitation, new electrospinning methods have been studied, and we developed an advanced electrospinning method and fabricated three-dimensional(3d) fibrous scaffold through optimization which include LA (monomer) addition. For the application of bone tissue engineering, beta-tricalciumphosphate(b-tcp) was mixed to produce bioactive fibrous scaffolds. The prepared 3D fibrous mats were verified to be beneficial to bone tissue regeneration through various physicochemical and biological tests. Key Words: 3D electrospinning, bioactive fibrous scaffold, bone tissue engineering, osteoconduction. Acknowledgements: (optioddnal, Times New Roman, Size 11, regular font ) [1] Chan-Hee park, et al. Preparation and characterization of LA/PCL composite fibers containing beta tricalcium phosphate (b-tcp) particles. Ceramics Internationals, 2014, 40;

166 The Interactions Of Nanofibers With Tissue Depends On The Material And The Site Of Implantation. Tomasz Kowalczyk 1, Beata Niemczyk 1, Tomasz Kloskowski 2, Arkadiusz Jundziłł 2, Marta Pokrywczyńska 2, Jan Adamowicz 2, Ryszard Strzałkowski 1,3, Bartłomiej Noszczyk 4 and Tomasz Drewa 2,5. 1 Laboratory of Polymers & Biomaterials, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland, 2 Department of Urology, Faculty of Medicine, Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland 3 Electron Microscopy Platform, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland 4 Department of Plastic Surgery, Medical Centre of Postgraduate Education, Warsaw, Poland. 5 Department of Urology and Oncological Urology, Nicolaus Copernicus Hospital, Torun, Poland Short Introduction Electrospinning of biodegradable/biocompatible polymers provides nonwovens to form e.g. scaffolds for tissue reconstruction or wound dressings. The polymeric material is free from the disadvantages of the acellular collagen matrix, e.g. the presence of allergens or pathogens, while it can be tailor-made. There is a need for short electrospun nanofibers, e.g. as a component of a gel scaffolds for tissue engineering. Research Design Electrospun membranes made of PLC or HSA were implanted on the rodent model under the skin, intraperitoneally or as a ureter implant. After a specified time histological analyses were performed to determine integration of nanomaterial with the surrounding tissue, its influence, and infiltration of blood vessels. The method of producing short of electrospun nanofibers with well-defined length and polydispersity is presented. It is a general method for elastic and rigid, organic and inorganic fibers. Main Results And Discussion The tissue response to nonwovens was dependent on the site of the implantation and the type of polymer. HSA inhibited the integration of tissues, as did some of the ureter implants made of PLC. In contrast, a network of blood vessels of a proper structure was growing into material implanted in the peritoneum. We have presented the method of creating short fibers from an electrospun polymer. With a different nonwoven topology, it was possible to obtain bands (ribbons) from nonwoven. Conclusion. There is no uniform biological response to the nanofibers. Depending on the material, it may either inhibit the integration of surrounding tissues, be encapsulated, cause moderate inflammation, and/or be overgrown by a network of blood vessels. The nonwoven structure influences its behavior towards post-processing, which has a key impact on the production of fiber bundles or ribbons. Key Words: Electrospun nanofibers, Tissue Engineering, Implants, Short Nanofibers. Acknowledgements: Participation in the Electrospin 2019 conference financed by the National Agency for Academic Exchange (NAWA) grant PPI/APM/2018/1/00045/U/001. The authors would like to thank following co-researchers: M Nowacki, M Bodnar, G Mikułowski, A Marszałek, M Frontczak-Baniewicz, G Mikułowski, J Gatherwright and C Gomez-Sanchez. [1] Jundziłł A, Pokrywczyńska M, Adamowicz J, et al. Vascularization Potential of Electrospun Poly(L-Lactide-co-Caprolactone) Scaffold: The Impact for Tissue Engineering [J] Medical Science Monitor, 2017,23: [2] Noszczyk BH, Kowalczyk T, Łyżniak M, et al. Biocompatibility of electrospun human albumin: a pilot study [J]. Biofabrication, 2015, 7: [3] Kloskowski T, Jundzill A, Kowalczyk T, et al. Ureter Regeneration The Proper Scaffold Has to Be Defined [J], Plos One, 2014, 9(8):

167 Study on the morphological, mechanical and thermal properties of poly(lactic acid) (PLA)/Hydroxyapatite(HA) /Dopamine composites nanofiber for tissue engineering Xiangfang Peng 1, Zhixiang Cui 1, Shengyu Hu 1, Junhui Si 1 1. College of Materials Science and Engineering, Fujian University of Technology, Fuzhou, China. Abstract: PLA/HA-PDA composite nanofibers were prepared by electrospinning with polylactic acid as the base material and HA-PDA particles as the reinforcing phase. The effects of HA-PDA particles on the state, mechanical properties and mechanical properties of PLA/HA-PDA scaffold were investigated. Composite scaffolds were characterized by scanning electron microscopy (FE-SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), water absorption, and MTT. These results showed that HA-PDA improves the mechanical properties, thermal stability, hydrophilicity and crystallization properties of PLA fibers; These results of cell culture showed that HA-PDA particles could promote the better adhesion, proliferation and growth of cells on PLA/HA-PDA composite fiber scaffolds, indicating that they have good biocompatibility. Keyword: polylactic acid, electrospinning, hydroxyapatite, dopamine Acknowledgements: The National Key Laboratory for the joint open project, The National Natural Science Foundation, The Fujian Provincial University Research Project and The Fujian Provincial University Outstanding Young Talent Research Program. Reference [1] Gong T, Heng B C, Lo E C M, et al. Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy [J]. Stem Cells International, 2016, 2016(24):1-13. [2] Wang S, Liu Y, Kong X, et al. Preparation of electrospun L-PLA/S-PLA fiber membrane and its application in drug release system [J]. New Chemical Materials, [3] Lynge M E, Van d W R, Postma A, et al. Polydopamine--a nature-inspired polymer coating for biomedical science.[j]. Nanoscale, 2011, 3(12):

168 Cellulose acetate efficient and environmentally friendly methylene blue dye adsorbent based on mussel design Xiangfang Peng 1,Zhixiang Cui 1, Jiaqi Cheng 1, Junhui Si 2 1. College of Materials Science and Engineering, Fujian University of Technology, Fuzhou, China. E- A Cellulose acetate fiber membrane was prepared by an electrospinning method and surfacemodified with dopamine to be used as a high-efficiency adsorbent for removing a cationic dye (methylene blue, MB) from an aqueous solution. The prepared CA, DA, CA/PDA fiber membrane were characterized using several techniques such as SEM, TEM, FESM, FTIR, N2 adsorption / desorption isotherms. The effects of initial solution ph, temperature, initial concentration and contact time were systematically investigated. The results show that the adsorption capacity at 25 can reach mg g-1. In addition, the adsorption kinetics indicate that the adsorption behavior follows a pseudo second-order kinetic model. The equilibrium adsorption data fits the Langmuir isotherm. Thermodynamic analysis shows that adsorption is an endothermic and spontaneous process. In addition, the hydrophilic properties and adsorption capacity of the CA/PDA fiber membrane are greatly improved compared to the CA fiber membrane. Key Word:Electrospinning, cellulose acetate, adsorption, dopamine, deacetylation Acknowledgements The authors gratefully acknowledge the financial supports for this research from The National Key Laboratory for the joint open project, The National Natural Science Foundation, The Fujian Provincial University Research Project and The Fujian Provincial University Outstanding Young Talent Research Program. [1] Ma F, Zhang N, Wei X, et al. Blend-electrospun poly(vinylidene fluoride)/polydopamine membranes: self-polymerization of dopamine and the excellent adsorption/separation abilities[j]. Journal of Materials Chemistry A, 2017, 5(27): [2] Fu J, Chen Z, Wang M, et al. Adsorption of methylene blue by a high-efficiency adsorbent (polydopamine microspheres): Kinetics, isotherm, thermodynamics and mechanism analysis[j]. Chemical Engineering Journal, 2015, 259:53-61.

169 Mimicry of Native Tissue fibrous hierarchical structure to enhance tendon repair Xianrui Xie, Dongsheng Li, Yujie Chen, Jinglei Wu and Xiumei Mo * State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, , Shanghai, P. R. China.. Introduction Tendon injuries are among the most common musculoskeletal problems. Tendon grafts are essential for the treatment of various tendon-related conditions because the inherently poor healing capacity of tendon tissues. Current clinical treatments for the replacement of damaged tendons involve autografts, allografts, and xenografts, which still present inevitable disadvantages. Tendon morphology and function are intrinsically related with their highly organized extracellular matrix (ECM) structure. In this study we have developed a knitted multiscale fibrous scaffold, which can mimic the native ECM and impart sufficient mechanical properties and further coated it with alginate so as to prevent the peritendinous adhesion. Results & Discussion These SEM images confirmed that PLCL/Ge was able to form continuous fibers surrounding the PET core yarn under the electrospinning conditions used in this study (Fig.1). The PET-PLCL/Ge yarn has an obvious core-sheath structure, forming a highly twisted core-sheath yarn. SEM analysis (Fig. 1d) of both 3D scaffolds further confirmed that the knitted construction exhibits higher porosity that is known to favor cellular infiltration and full scaffold colonization. The surface wettability of the scaffold is one of the main factors that determine cellular behavior. The dynamic water contact angle (CA) of PET scaffold soon dropped from 26.7 to 0 in two seconds. The CA of PET-PLCL scaffolds (CA: to 0 in six seconds) was higher compared to PET values. In addition, The CA of PET-PLCL-Ge scaffolds slowly down from 100 to 0 in eight seconds. This is due to PET scaffold has the largest pore size and exhibits higher porosity. In summary, the surface wettability of the knitted scaffold tended to be hydrophilic, which may contribute to cell proliferation. These three knitted scaffold does not have a significant impact on the Young s modulus (106.70±16.2, ±12.3 vs ±14.2 MPa) and ultimate tensile strength (34.64±2.32, 37.45±3.12 vs ±1.78 MPa). Based on its mechanical properties mentioned above, it presenting tensile properties within the range of native tendons (Young s modulus MPa and UTS MPa). [1] Figure 1. (A) SEM images showing the morphology of yarn (a: surface of PET-PLCL-Ge, b: cross-section of PET-PLCL, c: PET-PLCL-Ge) and knitted scaffold (d:pet, e:pet-plcl, f: PET-PLCL-Ge). (B) Dynamic water contact angle of knitted scaffold. (C) The stress-strain curves of knitted scaffold. Conclusions To summarize, we have developed a novel type a core-sheath structure was successfully built using a custom electrospinning equipment. A knitted medical fabric has created a promising surgically implantable scaffold with potential to enhance the endogenous repair of tendon tears. These scaffolds showed enhanced tendon regeneration potential when subjected to dynamic stimulation in both in vitro and in vivo conditions. Key Words: electrospinning, tendon, knitted scaffold, tissue engineering : [1] LaCroix A S, Duenwald-Kuehl S E, Lakes R S, et al. Relationship between tendon stiffness and failure: A metaanalysis[j]. J. Appl. Physiol., 2013, 115(1):

170 Electrospun and photocrosslinked gelatin/dextran maleic anhydride composite fibers for tissue engineering Xiaoping Yang 1, Dongzhi Yang 2*, Xiaolei Zhu 1, Jun Nie 1, and Guiping Ma 1* 1 Beijing Laboratory of Biomedical Materials, Key Laboratory of Biomedical Materials of Nature Macromolecules (Beijing University of Chemical Technology), Ministry of Education, Beijing University of Chemical Technology, Beijing, , P. R. China. 2 Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu , China. Developing natural polymers-based fibers is highly desirable for tissue engineering. In this study, an effective method to synthesize electrospun gelatin/dextran maleic anhydride (gelatin/dex-ma) composite fibers with enhanced physical and biological properties has been proposed. Photocrosslinkable Dex-MA was first synthesized and gelatin/dex-ma composite fibers were then prepared by electrospinning followed by photocrosslinking. The physical properties of the assynthesized composite fibers including water absorption, mechanical properties, and degradation were investigated. It was found that the physical properties of the composite fibers could be dramatically improved with the content of Dex-MA, where the tensile strength can be enhanced up to 1.75 MPa and the degradation can be increased up to 40.30%. In addition, the biocompatibility study in vitro showed that the composite fibers could support cell proliferation and adhesion. Our electrospun crosslinked gelatin/dex-ma fibers are potential to be applied in the field of tissue engineering. Figure 1. a) Scheme of electrospun and photo-crosslinking process. b) The cell adhesion Key words: natural polymers, electrospun fibers, photocrosslinking, tissue engineering Acknowledgements: The authors acknowledge funding from the National Natural Science Foundation of China (Grant No ). [1] Adam J. Engler, Shamik Sen, H. Lee Sweeney and Dennis E. Discher. Matrix elasticity directs stem cell lineage specification[j]. Cell, 2006, 126: [2] Chen W, Chen S, Morsi Y, Elhamshary H, Newhy M E, Fan C, et al. Superabsorbent 3D scaffold based on electrospun nanofibers for cartilage tissue engineering[j]. ACS Applied Materials & Interfaces 2016, 8:

171 Biomimic dual-oriented electrospun nanofibers for vascular regeneration Xingmao Li 1, Huang Lin 1, Long Li 1* 1 Collage of Materials and Metallurgy, Guizhou University, Guiyang, Guizhou Province, P. R. China. Cardiovascular disease remains to be one of the main threats to human health and life. While currently used artificial blood vessels are inefficient in replacing native small-diameter blood vessels (inner diameter < 6 mm), but prone to causing thrombosis, intimal hyperplasia and compliance mismatch, etc. In this study, multilayer electrospinning technology, combining methods such as coiling and folding, were used to prepare the biomimic nanofiber vascular tissue engineering scaffold, so as to mimic the multilayer and dual-oriented structure of native small diameter blood vessel and to guide smooth muscle cells and endothelial cells to form native blood-vessel-like anisotropic orientation by contact guidance effect. The multilayered and oriented structure was characterized by SEM. In the in vitro study, smooth muscle cells and endothelial cells were highly oriented along the nanofibrous direction due to the contact guidance effect. Moreover, phenotypic expression of these two kinds of cells were significantly higher than those on tissue culture plates. Fig. 1 The SEM images of the multilayered biomimic tissue engineering scaffold s cross section. a, the third layer. b, the gross morphology of this multilayered structure. c, the first layer. Inset, the schematic view of the multilayered structure according to b. Key Words: Electrospinning, biomimicking, vascular tissue engineering, dual-oriented (required, 4-5 keywords, separated by comma, Times New Roman, Size 11, regular font) Acknowledgements: This work is supported by National Natural Science Foundation of China ( ). [1] Long Li, Guangliang Zhou, Yi Wang, et al. Controlled dual delivery of BMP-2 and dexamethasone by nanoparticle-embedded electrospun nanofibers for efficient repair of critical-sized rat calvarial defect [J]. Biomaterials, 2015; 37: [2] Long Li, Guang Yang, Jinrong Li, et al. Cell behaviors on magnetic electrospun poly-d,l-lactide nanofibers [J]. Materials Science and Engineering C, 2014; 34:

172 Preparation and characterization of silk fibroin nanofibers loading mesenchymal stem cell-derived exosomes Xinran Song 1, Xinyu Lu, Huoyan Hong, Meiqi Sun, Hongsheng Wang * Collage of Chemistry, Chemical Engineering and Biotechnology, Donghua University, China * Introduction In recent years, studies have shown that mesenchymal stem cell (MSC)-derived exosomes (MSCE) play an important role in wound repair. It is noteworthy that exosomes, as active ingredients for wound repair, can avoid immune rejection and can also be used as vehicles targeted delivery of drugs. Electrospun silk fibroin (SF) nanofibrous dressings have been reported-have excellent effect on wound healing. In this study, a novel MSCE loaded SF nanofibrous wound dressing was fabricated via green electrospinning. Key words: Exosomes; Nanofibers; Silk fibroin; Wound repair. Materials & Methods The MSCE was obtained from the cell culture supernatant of BMSCs. SF nanofibers loading different amounts of MSCE were obtained by electrospinning with the mixture of aqueous solution of SF (20%(wt/v)) and MSCE. The composite nanofibers were characterized by scanning electron microscope (JSM-5600, Japan) and Image-J software (National Institutes of Health, USA). Results & Discussion Fig.1 SEM image and diameter distributions of the nanofibers (a-: SF; b-: SF/MSCE (100μg); c-: SF/MSCE (200μg); d. SF/MSCE (500μg). As shown in Fig.1, the electrospun SF/MSCE composite nanofibers have a round and smooth morphology with an average diameter about 600nm, and the addition of appropriate amounts of MSCE did not affect the spinnability of SF aqueous solution. Fig.2 indicated that SF/MSCE composite nanofibers were successfully fabricated. Fig.2 FTIR spectra of the nanofibers (a: SF/MSCE; b: SF; c: SF without crosslinking; d: MSCE) Conclusion A novel SF/MSCE composite nanofibers were successfully fabricated by green electrospinning, which laid the foundation for further research of this biomaterials serving in wound repair.

173 Well-aligned nanofibers for functional tendon tissue engineering Yaqiong Wang 1, Nv Wang 1 Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, Beijing Key Laboratory of Bioinspired Energy Materials and Devices, School of Chemistry, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, , P. R. China. Poor tendon repair is often a clinical challenge due to the lack of ideal biomaterials. Electrospun aligned fibers, resembling the ultrastructure of tendon, have been previously reported to promote tenogenesis. However, the underlying mechanism is unclear and the aligned fibers alone are not capable enough to commit teno-differentiation of stem cells. In this study, we demonstrated the potential of nanofibrous architecture to direct cell morphology, migration, and more complex biological processes such as differentiation and extracellular matrix deposition through topographical guidance cues. We designed aligned nanofiber scaffolds with the hypothesis that this would promote tenogenesis when seeded with MSCs. Then, we further prove that the structure-property relationship, electrospun meshes were made from a polyurethane elastomer with different fiber diameters and orientations and mechanically tested to determine the dependence of the elastic modulus on the mesh architecture. Key Words: aligned nanofibers, tendon scaffold, MSCs, mechanical property, electrospun [1] Zhang C, Wang X, Zhang E, et al. An Epigenetic Bioactive Composite Scaffold with Well-aligned Nanofibers for Functional Tendon Tissue Engineering[J]. Acta Biomaterialia, 2017:S [2] Brennan D A, Conte A A, Kanski G, et al. Mechanical Considerations for Electrospun Nanofibers in Tendon and Ligament Repair[J]. Advanced Healthcare Materials, 2018:

174 Self-Nanoemulsifying Electrospun Fiber Enhancing Drug Permeation Yi Xiang, Wenguo Cui* Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai , P. R. China. Electrospun fibrous membranes have been under extensive research as excellent drug delivery systems (DDS) and tissue engineering scaffolds[1]. Earnest endeavors have been devoted to the expedition of the potential of electrospun fibrous membranes to exhibit advanced properties as DDS. However, there have been difficulties in promoting the drug permeation in tissues with such carriers, which could determine its bioavailability and directly affect the therapeutic outcome. Here, we propose a Qualityby-Design strategy to fabricate self-nanoemulsifying electrospun fibers through blending of selfnanoemulsifying drug delivery system (SNEDDS) and polymers to enhance drug permeation[2]. The method is successfully replicated with both hydrophobic polymer poly-l-lacticacid (PLLA) and hydrophilic polymer polyvinylpyrrolidone (PVP). Owing to the nanoemulsion which formed spontaneously when the polymer contacts aqueous solution such as body fluid, the resulting drugladen fibrous membrane exhibits an outstanding drug permeation and therapeutic enhancement effect in a Franz cell experiment with ex vivo abdomen skin of rats, an artificial connective tissue model, and an in vivo rheumatoid arthritis model in rats. Meanwhile, the material also shows the capacity of rational regulation on the rate of drug release. These features of the present strategy establish our material as a new efficient approach for various clinical conditions calling for cure. Figure1 The scheme of drug release and absorption enhancement of self-nanoemulsifying polymeric fibers Key Words: electrospinning, self-nanoemulsifying drug delivery system, nanoemulsion, topical drug delivery, drug permeation Acknowledgements: This work was supported by the Shanghai Municipal Education Commission Gaofeng Clinical Medicine Grant Support ( ). [1].Cui WG, Zhou SB, Li XH. Drug-loaded biodegradable polymeric nanofibers prepared by electrospinning[j], Tissue Eng. 2006, 4(12), [2].Nastiti C, Ponto T, Abd E, et al. Topical Nano and Microemulsions for Skin Delivery [J]. Pharmaceutics 2017, 9(4): 37.

175 Electrospun gelatin nanofibers encapsulated with peppermint and chamomile essential oils as potential edible packaging Ying Zhou 1, Yadong Tang 1,2, Xingzi Lan 1, Xiaomin Miao 1, Han Wang 3, and Wenlong Wang 4 1 Department of Pharmaceutical Engineering, Guangdong University of Technology, Guangzhou, , China. 2 School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, , China. 3 Guangdong Provincial Key Laboratory of Micro-nano Manufacturing Technology and Equipment, School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou, , China. 4 School of Mechanical and Electric Engineering, Guangzhou University, Guangzhou, , China. Natural and edible materials have attracted increasing attentions in food packaging, which could overcome the serious environmental issues caused by conventional non-biodegradable synthetic packaging 1,2. In the present work, gelatin nanofibers incorporated with two kinds of essential oil (EO), peppermint essential oil (PO) and chamomile essential oil (CO), were fabricated by electrospinning for potential edible packaging application and the joint effect of PO and CO in gelatin nanofibers on bioactivities was also studied. Our results show that gelatin/eo nanofibers exhibited homogeneous and smooth morphology, and the existence of essential oils not only improves the hydrophilicity of gelatin nanofiber, but also makes gelatin nanofiber possess bioactivities, such as the protective effects against microbial and oxidative damage. Furthermore, the joint of PO and CO in gelatin nanofiber showed overall optimum bioactivities compared with single PO or CO because of the different composition of different essential oils. The MTT assay indicated the non-cytotoxicity of gelatin nanofibers incorporated with PO and CO. Thus, our studies suggest that the developed gelatin/po/co nanofiber could be a promising candidate for edible packaging. Key Words: Electrospinning, Gelatin, Essential oils, Edible packaging Acknowledgements: This work was financially supported by National Natural Science Foundation of China (Grant No ), and Project of Innovative Research Teams of Jiangmen (2017TD02). [1] Niu X, Liu Y, Song Y, et al. Rosin modified cellulose nanofiber as a reinforcing and coantimicrobial agents in polylactic acid /chitosan composite film for food packaging[j]. Carbohydr Polym, 2018, 183: [2] Luchese Cláudia Leites, Frick P J M, Zagonel D S N, et al. Effect of chitosan addition on the properties of films prepared with corn and cassava starches[j]. Journal of Food Science and Technology, 2018, 55(8):

176 Biodegradable core-shell electrospun nanofibers based on PLA and γ-pga for wound healing Yue Fang 1, Xianqi Zhu 2, Na Wang 2, Xuan Zhang 3, Dongzhi Yang 2*, Jun Nie 1, Guiping Ma 1* 1 Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing , China. 2 Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu , China. The repair process in wound healing is vital and complicated, which brings great challenge to researchers. Tissue engineering scaffolds provide a realizable approach for wound repair. In this study, nanofibers with Poly(γ-glutamic acid) (γ-pga) as the core and Polylactic acid (PLA) as the shell materials were prepared via coaxial electrospinning. The effect of flow rate on the structure and diameter of the core-shell nanofibers was investigated. The microstructure and morphology of the core-shell nanofibers were observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). In laser scanning confocal microscopy experiments (LSCM), core-shell nanofibers loaded with rhodamine and coumarin-6 were excited with red and green light respectively to further investigate the structure of core-shell nanofibers. The hydrophobicity and degradation of core-shell nanofibers were studied by water contact angle test and degradation performance test experiments. The in vitro cell culture study showed favorable biocompatibility of nanofibers. The in vivo animal experiment showed that PLA/γ-PGA core-shell nanofiber membrane was conducive to wound repair, where more than 90% re-epithelialization was observed. It suggested a promising and dependable material for tissue engineering and wound healing. Figure 1. (a) Photographic images of the extent of wound healing and (b) Wound size variation curve. Key words: Electrospinning, Core-shell nanofibers, γ-pga, Wound healing [1] Macneil S. Progress and opportunities for tissue-engineered skin[j]. Nature, 2007, 445: [2] Jiang S, Chen Y, Duan G et al. Electrospun nanofiber reinforced composites: a review[j]. Polymer Chemistry, 2018, 9(10): 1039.

177 Preparation and structural characterization of three-dimensional nanofiber scaffolds Yujie Chen, Xianrui Xie, Jinglei Wu, and Xiumei Mo* Donghua University (#2999 North Renmin Road Road, Shanghai , China) College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, , Shanghai, P. R. China.. Introduction:Electrospun nanofibers mimic the original structure of the extracellular matrix (ECM) and are widely used in scaffold materials for tissue repair and regeneration [1,2].Traditional nanofiber membranes have only a porous structure on the surface. The pore size between the fibers is usually smaller than the size of a single cell, limiting the transport of oxygen and nutrients, making it difficult for cells to penetrate and grow.to increase the pore size of electrospun nanofiber scaffolds, a simple and straightforward way is to modulate fiber diameters.the issue for this method is that the fibers with a size in micron scale lack the biomimetic property.here, we prepared different ratios of P(LLA-CL) with silk fibroin (SF) nanofiber membranes by electrospinning technology. We realized the transformation of 2D membranes to 3D membranes by gas foaming technology. It can be seen by scanning electron microscopy that the extended three-dimensional nanofiber scaffold forms a layered structure. This method has broad application prospects in the preparation of functional threedimensional nanofiber scaffolds. 3D membraneshas has good biocompatibility, can be degraded by human body and be used for in vitro tissue model engineering, tissue repair, etc. Results & Discussion Scanning electron microscope shows that wrinkles appear on the surface of the fiber mat after foaming. There is obvious delamination between the layers, and the interlayer spacing is also significantly improved (Fig. 1d). The ATR-FTIR results showed that PLCL was mainly the absorption peak of ester bond at 1765 cm -1.The absorption peak of amide bond was mainly at 1630 cm -1 and 1520 cm -1. The water contact angle test showed that the hydrophilicity of the fiber membrane also increased as the SF component increased, the fiber membrane with a ratio of 75% SF has a contact angle of ±2.35, showing excellent hydrophilicity. a b c d (A) (B) (C) Figure 1. (A) SEM image of surface and cross-section of the fiber mat(a, cross-linked surface; b, foamed surface; c, cross-linked section; d, foamed section) (B) ATR-FTIR spectra of different PLCL/SF ratio scaffolds and raw materials; (C) Water contact angle of SF/PLCL fiber mat Conclusions:The three-dimensional electrospun nanofiber scaffold obtained by the foaming technique has a distinct layered structure and an enlarged pore. The fiber membrane with more SF components has good hydrophilicity. This new three-dimensional scaffold material can be used in areas such as wound dressing and tissue scaffold. Key words:electrospinning,three-dimensional scaffold,foaming technology,tissue engineering [1]J. Xie, X. Li, J. Lipner, et al. Aligned-to-random nanofiber scaffolds for mimicking the structure of the tendon-to-bone insertion site[j].nanoscale, 2010,(2): [2]K.M. Kennedy, A. Bhaw-Luximon, D. Jhurry, Cell-matrix mechanical interaction in electrospun polymeric scaffolds for tissue engineering: implications for scaffold design and performance[j].acta Biomater,2017,(50):

178 Controlled Release of Exsomes from Nanoyarn Scaffold ZHU Jingjing, MO Xiumei* Collage of Chemistry, Chemical Engineering and Biotechnology, Donghua University, China * Introduction Electrospinning technology is widely used in the field of regenerative medicine for its ability to fabricate ultrafine fibers with simulated extracellular matrix. Recently, we found exosomes, obtained from adipose derived stem cells, contained many growth factors, which could promote the growth of urotherial cells. Therefore, hydrogel-nanoyarn composite scaffold that released ADSC-Exos was fabricated for urethral repair. Materials & Methods Poly(L-lacticacid)-co-poly(e-caprolactone) P(LLA-CL) (Mw=300kDa; LA:CL=75:25) was purchased from Daigang Medical Material Co., Ltd., Shandong, China. A water vortex was created in the basin with a hole (diameter, 8mm) at the bottom. Then, a tank was used to deposit the drained water and then it was pumped back into the basin to maintain the water level. A solution of Col-I and P(LLA-CL) (12 wt %, Col-I:P(LLA-CL)=10:90) in HFIP was loaded into a syringe and fed at the rate of 1 ml/h as shell solution and 25%, 50%, 75% exsomes diluted with PBS was loaded at 0.1mL/h as core solution with a voltage of 15 kv. A rotating mandrel (60 r/min) was used as the collector to collect the yarn by flowing along with the water through the hole. The yarn was frozen at -80 for 6 h and then freeze-dried overnight. Results & Discussion Figure 1 SEM of nanofiber (A) and nanoyarn(b). Scanning Electron Microscopy images were recorded a scanning electron microscope (SEM). As shown in Figure 1B, image of nanoyarn was obtained, that nanoyarns were bound from multiple nanofibers. Figure 2 Proliferation viability of HFFs after culturing in 1,3,5 days seeded in nanoyarn with different concentration of exsomes via CCK-8 assay. Figure 2 show that HFFs exhibit best proliferation in the nanoyarn with 50% exsomes due to the number of signal receptors on the surface of cell is limited that high concentration of exsomes exhibits inhibition. Conclusion Nanoyarn with shell-core structure was prepared successfully by means of dynamic liquid electrospinning, which has the advantage of good biocompatibility, and provides a good application prospect for tissue engineering regeneration and repair. Acknowledgements: Sponsoring fund: National Natural Science Foundation of China ( ), Shanghai Science and Technology Commission, International Cooperation Project ( ).

179 1 Nitric Oxide Releasing Electrospun Nanofibers for Antimicrobial Bone Tissue Engineering Man Li 1, Jenny Aveyard 1, Fiona McBride 2, Rasmita Raval 2, Judith M. Curran 1, and Raechelle A. D Sa 1 Department of Mechanical, Materials and Aerospace Engineering, University of Liverpool, Liverpool, L69 3GH, United Kingdom 2 Department of Chemistry, University of Liverpool, Liverpool, L69 3GH, United Kingdom Introduction Bacterial adhesion and biofilm formation leading to infections is a major reason for failure of guided bone regeneration. 1 Compared to traditional bactericidal agents such as antibiotics, antiseptics and silver, which can lead to drug resistance or high cytotoxicity, nitric oxide (NO) is an attractive antimicrobial as it highly effective without leading to antimicrobial resistance. 2, 3 However as NO is a reactive gas, with a relatively short half-life, delivery of this antimicrobial is challenging. In this study we have synthesized NO releasing coatings on poly(ε-caprolactone) (PCL) and gelatin blended nanofibers. The NO donor used is an N-diazeniumdiolate which is formed using amino functionalities in the nanofibers. The biofilm inhibition to Staphylococcus aureus (S. aureus) was employed in evaluating the biological response of NO release nanofibers. Research Design Five blends of PCL:gelatin nanofibers were prepared in mass ratios of 100:0, 75:25, 50:50, 25:75 and 0:100. Then samples were placed in a NO reactor to synthesis diazeniumdiolates. Diazeniumdiolates modified samples were analysed using contact angle and XPS. NO release was monitored using a chemiluminescent NO detector. Biofilm CFU assays were performed to determine the inhibition of biofilm formation on NO releasing surfaces after 6h and 24h incubation. In addition, SEM was used to determine S. aureus morphology after 6h incubation on NO releasing surfaces. Results and Discussion Results have demonstrated that the formation of diazeniumdiolates on nanofibers. The binding energies of N 1s peak at ~401 ev for N + and ~402 ev for N-O were observed from XPS analysis, representing the (O - )N + =N(O - ) group. The kinetics of NO release were dependent on ph, with acidic conditions (ph 4) resulting in the release of higher NO concentrations than ph 7.4 and ph 8.5. The surface releasing the highest concentration of NO showed more than 1 log reduction in S. aureus biofilm formation. Conclusions Diazeniumdiolates were successfully PCL:gelatin nanofibers. These electrospun membranes have the potential to be use as anti-infectives for guided bone regeneration. Figure 1. Electrospun fibers SEM and nitric oxide release profiles in ph 4. Key Words: Electrospin, Gelatine/PCL, Nitric oxide, Antimicrobial, Bone regeneration [1] Hetrick E M, Shin J H, Stasko N A, et al. Bactericidal Efficacy of Nitric Oxide-Releasing Silica Nanoparticles [J]. Acs Nano, 2008, 2(2): [2] Nablo B J, Rothrock A R, Schoenfisch M H. Nitric Oxide-Releasing Sol Gels as Antibacterial Coatings for Orthopedic Implants [J]. Biomaterials, 2005, 26(8):

180 Nozzle-free electrospinning of PCL-backbone Silk fibroin/poly(glycerol sebacate) fibrous skin substitute mats Antonios Keirouz 1, 2, Mariia Zakharova 1, Jae Hoon Kwon 1, Anthony Callanan 1, Vasileios Koutsos 1, Giuseppino Fortunato 2, Norbert Radacsi 1 1 The University of Edinburgh, School of Engineering, Robert Stevenson Road, Edinburgh, EH9 3FB, U.K. 2 Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Protection and Physiology, St. Gallen, CH-9014, Switzerland. Biomimetic electrospun material for wound healing and skin regeneration emphasize on the development of biologically responsive constructs that incorporate an Extracellular matrix (ECM)-like architecture, which mitigates the necessary support for guiding cellular response and activities, ultimately allowing for mediated reepithelialization and neo-tissue formation. Natural polymeric-based materials, such as silk fibroin (SF), encompass great biocompatibility. Poly(glycerol sebacate) (PGS) is an attractive biomaterial that exhibits tailored mechanical properties and bioresorbability pertinent to varying its polycondensation parameters [1]. Poly(caprolactone) (PCL) is a well-studied semi-crystalline synthetic bio-polymer, where its prevalent use lays on its good elastic properties. Main aim of this study was the fabrication of PCL-backbone SF/PGS electrospun mats that appose the diverse properties of these materials in a final construct. In this work: 1. A nozzle-free electrospinning aparatus was developed, comprised of a rotating cylinder electrode submerged within a Teflon pool, and a biased rotating collector electrode under constant supply of nitrogen gas (Figure 1). A high potential difference of 60 kv was applied between the two rotating electrodes (+30/-30 kv), resulting in the formation of multiple Taylor cones on the rotating electrode surface immersed in the solution bath, from which jets stretched to form fibers in an upwards motion. 2. A variation of the conventional protocol for the extraction of silk fibroin from Bombyx mori cocoons (molecular cut-off technique), based on ethanol precipitation, was exploited [2,3]. 3. The effect of the pre-polymerized (ppgs) and cured forms of PGS on the composite's chemical behavior, mechanical stability, wettability and viability, was assessed. We found: 1. The fiber morphology and mechanical behavior are dependent on the polymerization time of the PGS. 2. FTIR, XPS, DSC and TGA asserted the presence of all three polymers in the composite structure. 3. The degradation rate of PGS within the scaffolds was retarded by the presence of SF and PCL. 4. The wettability was manipulated based on the proportion of PGS and ppgs within the scaffold. 5. In vitro studies with fibroblasts presented good viability, attachment and proliferation properties. Our findings suggest that the trinary model developed can be a promising candidate as substitute constructs for skin regeneration. Figure 1. Schematic representation of the nozzle-free electrospinning setup. A macrograph of the fibrous scaffold and SEM micrographs of the fibers with and without seeded fibroblasts. Key Words: nozzle-free electrospinning, Poly(glycerol sebacate), Poly(caprolactone), silk fibroin [1] Wang Y, Ameer G A, Sheppard J P, Langer R. A tough biodegradable elastomer [J]. Nature Biotechnology, 2002, 20(1): [2] Huang Y, Bailey K, Wang S, Feng X. Silk fibroin films for potential applications in controlled release [J]. Reactive and Functional Polymers, 2017, 116(5): [3] Rockwood D N, Preda, R C, Yücel T, et al. Materials fabrication from Bombyx mori silk fibroin [J]. Nature Protocols, 2011, 6(11):

181 4.2 Smart nanofibers and multifunction materials

182 Lightweight and Flexible Hybrid Film Based on Delicate Design of Electrospun Nanofibers for High-Performance Electromagnetic Interference Shielding Li Huang 1, Jianjun Li 2, Ye Yuan 1,2 1 School of Materials Science and Technology, Hebei University of Technology, Tianjin, , People s Republic of China. 2 National Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Harbin Institute of Technology, Harbin , People s Republic of China. As the noticeable growing rate of electronics, materials with good flexibility and high conductivity that can provide electromagnetic interference (EMI) shielding with minimal thickness are urgently needed. Here, for the first time, we demonstrate the potential of a non-woven composite film with unique core-shell and sandwich combined microstructure for EMI shielding. A reduced graphene oxide coated non-woven fabrics composite film exhibited EMI shielding effectiveness of 32dB (specific EMI shielding effectiveness can be db cm 2 g -1 ).This performance originates from the high electrical conductivity of FSPG films (0.71S/cm) and multiple internal reflections from the interconnected core-shell and sandwich microstructure in free-standing films. The mechanical flexibility offered by the films enable them to be considered as a new alternative material with efficient EMI shielding. Key Words: electromagnetic interference shielding, nanofibers, electrospinning, hybrid film, mechanical properties) [1] Ji H, Zhao R, Zhang N, et al. Lightweight and Flexible Electrospun Polymer Nanofiber/Metal Nanoparticle Hybrid Membrane for High-Performance Electromagnetic Interference Shielding [J]. NPG Asia Materials, 2018, 10 (8):

183 Preparation and characterization of super-absorbent and hydrophobic membranes for textile ergonomics in alpine environment. Michele Modesti 1, Martina Roso 1, Alessandra Lorenzetti 1, Carlo Boaretti 1, Riccardo Donadini 1, Daniel Sadlacek, Michael Hasler 2 1 Department of Industrial Engineering, University of Padova, Via Marzolo,9 3513, Italy. 2 Research Centre Snow, Ski and Alpine Sports, University of Innsbruck, Fuerstenweg 185 A-6020 Innsbruck, Austria. In many extreme climatic situations, breathable fabrics protect the human body from external heat, wind, water, and many harmful agents, and at the same time it also permits effective transmission of moist vapor from inside to outside atmosphere [1]. The present work shows the development of innovative waterproof breathable membranes based on super-absorbent and super-hydrophobic layers of different electrospun materials. In order to develop super absorbent membranes, Polyacrylamideco-acrylic acid (PAAM-co-AAc) sodium salt has been chosen as raw material, according to its well known ability to adsorb water. Moreover this polymer is water soluble and it means that it can be electrospun from water solution. Its ability to absorb water will be exploited as soon as it will be at least partially crosslinked and consequently water insoluble. This property was achieved thanks to the thermal cross-linking between the acrylic acid part of the polymer and a certain amount of polyvynil alcohol [2]: a detailed study of the temperature-time effects was carried out in order to define the degree of cross-linking. On the other hand, a super hydrophobic electrospun membrane was produced and optimized by coaxial electrospinning, wherein a thermoplastic polyurethane (TPU) thin shell ensured flexibility and a blended polyvinylidene-polytetrafluorethilene (PVDF-PTFE) core was responsible for the waterproof behavior. Figure 5. PAAM-co-AAc/PVA crosslinked super-absorbent membrane after water immersion. Figure 6. Confocal image of coaxial TPU (shellgreen),pvdf/ptfe (core-red). Right corner: contact angle (θ) measurement: θ= 120.9±0.7 Key Words: super-adsorbent electrospun fibers, hydrophobic fibers, coaxial electrospinning Adknowledgment This research project was founded by: AlpSporTec, Interreg V Italy-Austria , ITAT1027, CUP C92F [1] Mukhopadhyay A., Midha V. K. J.Industrial textiles, 2003,37 (3), [2] Kumeta K., Nagashima I., Matsui S., Mizoguchi K. J. Appl.Polym. Sci., 2003, 90, [3] Truong Y.B., Choi J., Mardel J., Gao Y., Maisch S.,Musameh M., Kyratzis I.L. Macromol. Mater. Eng. 2017, 302,

184 Hydrophilic Enhanced Red Blood Cell-like PEG-PLGA Janus Microparticles with Magnetic-Luminescent Bifunction Junwei Xu 1, 2, Yingnan Zhang 1, 2, Yunxue Jia 1, 2 1, 2,*, Ping Li 1 School of Biological Science and Medical Engineering, Beihang University, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing , China. 2 Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, 10083, China. In the field of drug delivery system, bionic red blood cell-like (RBC-like) microparticles (MPs) are considered ideal drug carriers for their unique shape. 1 In order to get better treatment results, in addition to imitate on the shape, it is more desirable to make the MPs as hydrophilic as RBCs are. This work aims to produce RBCs-like Janus MPs (poly(lactic-co-glycolic) (PLGA)-poly(ethylene glycol) (PEG)/Fe 3 O 4 )//(PLGA-PEG/NaYF 4 :Eu 3+ ) as magnetic-luminescent drug delivery system by double-needle electrospray. With magnetic-luminescent bifunction, the RBC-like MPs plays a better role in magnetic targeting, bioimaging, and fluorescent tracing. As shown in Fig.1, the MPs prepared were biconcave discoid similar to RBCs. The Janus structure weakened the quenching effect of magnetic materials on luminescent materials, so that RBC-like MPs showed a more excellent luminescent property. 2 PEG, a kind of hydrophilic material, was added to enhance the hydrophilicity of the RBC-like MPs. 3 As shown in Fig. 2, when the ratio of PEG/PLGA was 20% (w/w), the contact angle of the MPs was about 65. The cell viability assay of RBC-like MPs on pre-osteoblast MC3T3-E1 cells and human umbilical vein endothelial cells (HUVEC) suggested that they had no obvious cytotoxicity. Compared with MPs without PEG, the RBC-like PLGA-PEG Janus MPs showed more superior on cell adhesion. Hydrophilic enhanced RBC-like PEG-PLGA Janus MPs with magnetic-luminescent bifunction will show great potential applications in the field of drug delivery system. Fig.1 SEM image of RBC-like PEG-PLGA microparticles. Fig.2 Contact angles of RBC-like PEG-PLGA microparticles containing 0%, 5%, 10% and 20% PEG. Key Words: Hydrophilic enhanced, RBC-like PEG-PLGA Janus microparticles, Magneticluminescent bifunction, Double-needle electrospraying Acknowledgements: This work was supported by funds from National Natural Science Foundation of China (NSFC) Research Grant ( , , , ), and also supported by 111 Project (B13003). [1] Li P, Qi B, Li K, et al. Study on the formation and properties of red blood cell-like Fe 3 O 4 /TbLa 3 (Bim) 12 /PLGA composite particles [J]. RSC Adv., 2018, 8(23): [2] Ma Q L, Yu W, Dong X T, et al. Janus nanobelts: fabrication, structure and enhanced magneticfluorescent bifunctional performance [J]. Nanoscale, 2014, 6(5): [3] Li J, Zhu J H, He T, et al. Prevention of intra-abdominal adhesion using electrospun PEG/PLGA nanofibrous membranes [J]. Mater. Sci. Eng. C Mater. Biol. Appl., 2017, 78:

185 Electrospun 2 Nanofibers as Novel fillers for Dielectric Elastomers Zhaoxia Luo 1, Yongri Liang 2*, Shipeng Wen 1, Tairan Liu 1, Liqun Zhang 1, Li Liu 1* 1 Beijing Engineering Research Center of Advanced Elastomers, Beijing University of Chemical Technology, Beijing , China. 2 College of Materials Science and Engineering, Beijing Institute of Petrochemical Technology, Beijing , P. R. China. Dielectric elastomers (DEs) are one electronic type of electroactive polymer material that have attracted much interest due to their outstanding performances, including short time response, high energy density, light weight, high coupling efficiency, large strain, as well as flexibility. Those various excellent properties give them potential applications in actuators, power generators, artificial muscles, and energy harvesters. However, the lower dielectric constant of DEs is one of important factors to restriction of achieving higher performance. Therefore, how to improve the dielectric constant of DEs while without increasing the modulus is one of important strategy. In this work, we fabricated a hierarchical structured silica nanofibers with silver nano-particles using electrospinning technique and characterized the structure and morphology of the silica- NFs/polyurethane(PU) composites and investigated the mechanical properties, dielectric properties and electromechanical properties of composites. Our results showed that the Electrospun can act as a novel filler for fabrictation of higher performance DEs. Key Words: Electrospinning, Dielectric Elastomers, Silica Nanofibers, Silver, PU Acknowledgements: This work was supported by the National Natural Science Foundation of China (grant numbers , ); Funding Project of Basic Scientific Research Operating Expenses of Central Universities (JD1805); Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan (CIT&TCD ) : [1] L.J. Romasanta, M.A. Lopez-Manchado, R. Verdejo,et al. Increasing the performance of dielectric elastomer actuators:a review from the materials perspective[j]. Progress in Polymer Science, 2015, 51(2): [2] Shipeng Wen, Li Liu, Lifeng Zhang, Qi Chen, Liqun Zhang, Hao Fong, et al. Hierarchical electrospun SiO2 nanofibers containing SiO2 nanoparticles with controllable surface-roughness and/or porosity [J]. Materials Letters, 2010, 64(4):

186 Pre-recycled Ultra-light and flexible electrospun polymer/high Z materials composite nanofiber membrane for high-energy ray shielding and photocatalytic degradation Dayong He, Yuying Ma, Nan Zhang, Ju Qiu, Bolun Sun, and Ce Wang* Alan G. MacDiarmid Institute, College of Chemistry, Jilin University, P.O.Box , Changchun, China. High energy ray such as X-ray and γ-ray employed in medical imaging is considered hazardous to human body if prolonged exposed without protection, but traditional protecting clothing such as lead aprons are heavy, uncomfortable to wear, meanwhile lead compounds are toxic and polluting, which limits their applications. In recent years, many high Z materials (where Z stands for atomic number) except for lead composited with polymer were developed to replace lead and its compounds [1]. Among these studies, recycling of precious high Z materials such as rare earth materials, tungsten oxide, bismuth oxide, etc was not considered, which leads to the loss of rare substances and a certain degree of pollution. In this work, we developed a series of high energy ray shielding materials (Fig.1) based on polymer/high Z materials composite nanofiber membranes, which combine high energy ray protection and recyclability. Owing to the exposed active crystal on the integral nanofiber membranes, the recycled composite nanofiber membranes could serve as photocatalysts in wastewater degradation treatment [2]. In our experiment, the shielding rate of 30 kev x-ray was 92% after the thickness of multiple membranes was superimposed to 2mm, the density of the composite is only 0.4~0.6 g/cm3. In the photocatalytic degradation test for all selected cationic pollutants, the degradation rate was higher than 95% after 4 h of photocatalytic degradation (fig.2), and the composite nanofiber membrane had excellent cycle performance, and the degradation rate decreased by only 0.6% after 5 cycles of catalytic degradation (fig.3), it ensures that the shielding materials will continue to create economic value in the field of water treatment after the end of their life cycle. Key Words: high Z materials, X-Ray shielding, γ-ray shielding, recyclable materials. photocatalytic degradation, Acknowledgements: The authors are thankful for funds from National Natural Science Foundation of China (No.: and ). [1]Nambiar S, Yeow J T W, et al. Polymer-Composite Materials for Radiation Protection[J]. ACS Applied Materials & Interfaces, 2012, 4(11): [2] Tian J, Sang Y, Yu G, et al. A Bi 2 WO 6 -based Hybrid Photocatalyst with Broad Spectrum Photocatalytic Properties Under UV, Visible, and Near-Infrared Irradiation[J]. Advanced Materials, 2013, 25(36):

187 Fabrication of Under-liquid Dual Superlyophobic Nanofibrous Polymer Membranes by Coating Thin Film Composites: Application and Design Principle Qifei Wang 1, Yang Wang 2, Baixian Wang 1, Zhiqiang Liang 1, Jiancheng Di 1, and Jihong Yu 1,3* 1 State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, , P. R. China. address: 2 Department of Mechanical Engineering, City University of Hong Kong, 83th Tat Chee Avenue, Kowloon, Hong Kong 3 International Center of Future Science, Jilin University, 2699 Qianjin Street, Changchun , P. R. China. * Correspondence: Surfaces with under-liquid dual superlyophobicity have garnered tremendous interest because of their promising applications, but their underlying nature remains unexplored which restricts the designed construction of such surfaces. [1] Herein, we systematically modulated the chemical compositions of the electro-spun polyacrylonitrile (PAN) nanofibrous membranes by coating the thin film composites with different terminal groups over the PAN nanofibers, affording the membranes under-water oleophobicity/under-oil hydrophilicity, under-water oleophilicity/under-oil hydrophobicity, and underliquid dual lyophobicity. Among them, the representative 4-cyan-Ph-terminated membrane exhibited under-liquid dual superlyophobicity, which could realize efficient separation of all types of oil/water mixtures. We found that the three different under-liquid wetting behaviors can be classified in terms of the intrinsic water contact angle (θ w ). By comparing the total interfacial energy, [2] we proved that the under-liquid dual lyophobic surfaces were thermodynamically metastable. On this basis, we could predict the θ w of rough surfaces with the under-liquid dual lyophobicity in a given oil-water-solid system (e.g., in cyclohexane-water-solid system, R = 2). This work provides a design priciple for the fabrication of under-liquid dual superlyophobic surfaces. Figure 1. The fabrication of 4-cyan-Ph-terminated thin film composite PAN nanofibrous membranes (CTFPNM) and its application in oil/water system. The CTFPNM exhibits core-shell fibrous morphology, revealing under-liquid dual superlyophocity. It could realize efficient separation of all types of oil/water mixtures Key Words: under-liquid dual superlyophobicity, membranes, electrospinning, thin film composite, oil/water separation Acknowledgements: We acknowledge the National Natural Science Foundation of China (Grant No and ), the 111 Project (No. B17020) and the Jilin Province/Jilin University Coconstruction Project-Funds for New Materials (SXGJSF2017-3) for supporting this work. [1] Tian, X., Jokinen, V., Li, J., et al. Unusual dual superlyophobic surfaces in oil-water systems: the design principles. [J]. Adv. Mater. 2016, 28(48): [2] Wong, T.S., Kang, S.H., Tang, S.K., et al. Bioinspired self-repairing slippery surfaces with pressure-stable omniphobicity. [J]. Nature, 2011, 477(7365):

188 Functional sponges from short electrospun fibers Andreas GREINER University of Bayreuth Macromolecular Chemistry, Universitätsstrasse 30, Bayreuth, Germany Abstract: Sponges are open-cellular materials while foams are defined as closed cellular material. Spongy materials have received considerable interest in materials science for various applications. Ultralight sponges (density < 10mg/cm3) offer unique advantages such as low weight and large pore-volume. We found that dispersed short electrospun fibers could selfassemble to ultralight polymer sponges which show decent compressibility and potential for application in tissue engineering. The mechanical properties of the sponges were improved considerably by chemical vapor deposition of poly(p-xylylene) (PPX) without significant increase in density. These sponges showed very good heat insulation and also superhydrophobic properties which makes them of particular interest for textile application and oil/water separation. The concept of sponge property enhancement by post-processing coating was extended to liquid coating which was shown recently for polyimide sponges. The sponges showed very good compressibility, very high thermal stability even on air, very low volume shrinkage, and very good heat insulation. The sponge showed also exceptional performance as carrier for nanoparticle catalysts. These spongy catalysts were reusable many times and showed the highest reaction rates as comparted to other heterogeneous systems. The polymer sponges could take up a lot of guest material due to their large pore volume. Consequently, the ultralight sponges could take liquids up to 700 times of their own weight. In this state sponges behave rheologically like a gel and in fact show the characteristics of an organogel. Since organogels are prepared by different route we have defined the gels made by filling of the pores of the sponges as spongy gels. The sponges could also take up a large amount of drug and display retarded drug release as shown recently for the anti-malaria drug artemisone. Recently, we could show, that superhydrophobic hollow sponges based on electrospun fibers could be utilized as reaction containers for the highly efficient absorption of CO 2 and biomineralisation of CaCO 3. Biography: Andreas GREINER received his Ph D. degree in Chemistry from the University of Marburg in 1988 and joined did his postdoc in 1989 at the University of California, Santa Barbara, USA. He was appointed associate professor for organic chemistry and macromolecular chemistry at the University of Mainz in In 2000 he became full professor for polymer chemistry and technology at the University of Marburg and joined in 2012 University of Bayreuth as distinguished professor for macromolecular chemistry. Since 2013 he is heading the business unit Future Solution of New Materials Bayreuth GmbH. Present research topics are functional biobased polycarbonates, electrospinning of polymer mesofibers, polymerfunctionalized nanoparticles, poly(p-xylylene)s by CVD, polymers for coatings, filtration, textiles, medicine, pharmacy, agriculture, and as electrodes for microbial fuel cells. Greiner has authored more than 350 scientific publications and was ranked no. 36 in Thomson Reuters s top 100 materials science citation ranking list out of materials scientist for the decade Greiner is teaching at the Zhejiang University and is guest professor at Donghua University and Nanchang Normal University.

189 Robust Fluorine-free Superhydrophobic Waterproof and Breathable Nanofibrous Membranes Junlu Sheng, Zhe Li, Yongbo Yao, and Zhiyong Yan College of Materials and Textile Engineering, Jiaxing University, Jiaxing , China ABSTRACT Superhydrophobic waterproof-breathable membranes have attracted considerable interests owing to their multifunctional applications in self-cleaning, anti-icing, anticorrosion, outdoor tents, and protective clothing. 1-2 Despite the researches pertaining to the construction of superhydrophobic functional membranes by nanoparticle finishing have increased drastically, the disconnected particle component is easy to fall off from the membranes under deformation and wear conditions, which has restricted their wide use in practice. Here, robust superhydrophobic microporous membranes were prepared by dip-coating amino-silicone oil (ASO) onto the electrospun polyacrylonitrile (PAN) membranes, followed by SiO 2 nanoparticles (SiO 2 NPs) blade coating (as shown in Figure 1). Compared with hydrophilic PAN membranes, the modified membranes exhibited superhydrophobic surface with an advancing water contact angle up to 156 o, after introducing ASO as low surface energy substance and SiO 2 NPs as filler to construct the multi-hierarchical rough structure. Varying the concentrations of ASO and SiO 2 NPs systematically, the PAN electrospun membranes modified with 1 wt% ASO and 0.1 wt% SiO 2 NPs were endowed with good water-resistance (74.3 kpa), modest vapor permeability (11.4 kg m -2 d -1 ) and air permeability (20.5 mm s -1 ). Besides, the inorganic-organic hybrid coating of ASO/SiO 2 NPs could maintain its superhydrophobicity even after 40 abrasion cycles. The as-prepared membranes were found to resist variations on the ph scale from 0 to 12, and retained their water repellent properties when exposed to harsh acidic and alkali conditions. This facile fabrication of durable fluorine-free superhydrophobic membranes simultaneous with good waterproofbreathable performance provides the advantages for potential applications in self-cleaning materials and versatile protective clothing. Figure 1. Illustration of the preparation of ASO/SiO 2 NPs modified PAN superhydrophobic waterproof-breathable nanofibrous membranes. Key Words: Electrospinning, Nanofibrous membranes, Fluorine-free, Superhydrophobic, Waterproof and Breathable [1] Xue C H, Li Y R, Zhang P, et al. Washable and Wear-Resistant Superhydrophobic Surfaces with Self-Cleaning Property by Chemical Etching of Fibers and Hydrophobization [J]. ACS Appl. Mater. Interfaces, 2014, 6: [2] Feng X J, Jiang L. Design and Creation of Superwetting/Antiwetting Surfaces [J]. Adv. Mater., 2006, 18:

190 Multifunctional piezoelectric flexible motion and temperature sensor based on polymer/li-doped ZnO nanowires nanocomposite S.-H. Shin 1, and I. D. Kim 1 1 Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea. Recently, biomimetic electronic sensors have been actively investigated to develop highly sensitive and multifunctional sensors that mimics the sensory system of different animals. 1 Development of such devices has a significant impact on robotics and health care applications. 2 Recently, various tactile sensors that can simultaneously perceive thermal and mechanical stimuli in dynamic condition have been developed. 3 However, it is still challenging to integrate multiple functionalities in a single device due to complexities and difficulties in fabricating on a flexible substrates. In this work, we report a simple approach to fabricate high performance multifunctional flexible piezoelectric tactile sensor. Using silver (Ag) nanowires (NWs), PEDOT:PSS, and lithium (Li)-doped ZnO NWs, we developed E-whisker, which can detect mechanical strain, temperature, and subtle vibration or surface roughness. Specifically, Si wafer was treated with anti-adhesive trichloro(1h,1h,2h,2h-perfluorooctyl) silane (FOTS), followed by Ag NWs and PEDOT:PSS spray-coating and transferring processes using polydimethylsiloxane (PDMS). Subsequently, Li-doped ZnO NWs-PDMS composite was sandwiched between PDMS covered Ag NWs electrode layers. The both of strain and temperature sensitivities of the developed sensor were comparable to the previous report and demonstrated superior mechanical durability. In addition, owing to the piezoelectric element, the sensor can more precisely detect the objects in dynamic condition. The approach introduced here is a simple, effective, and cost-competitive route to realize the high performance multifunctional artificial electronic sensor devices. Figure 1. Piezoelectric sensing performance for motion detection. The sensing way enables the magnitude, direction, and speed of target object, simultaneously. Key Words: multifunction, piezoelectric sensor, flexible device, nanowire-polymer structure, dynamic sensing [1] Takei, K. Takahashi, T. Ho, J. C. Ko, H. Gillies, A. G. Leu, P. W. Fearing, P. W. Javey, A. Nanowire Active-Matrix Circuitry for Low-Voltage Macroscale Artificial Skin. Nat. Mater. 2010, 9: [2] Hussain, A. M. Lizardo, E. B. Torres Sevilla, G. A. Nassar, J. M. Hussain, M. M. Ultrastretchable and Flexible Copper Interconnect-Based Smart Patch for Adaptive Thermotherapy. Adv. Healthcare Mater. 2015, 4(5): [3] Vuorinen, T. Niittynen, J. Kankkunen, T. Kraft, Thomas M. Mäntysalo, M. Inkjet-Printed Graphene/PEDOT:PSS Temperature Sensors on a Skin-Conformable Polyurethane Substrate. Sci. Rep. 2016, 6:

191 Bioinspired Smart Graphene Separation Membranes Jingchong Liu 1, 2, NüWang 1, 2, and Yong Zhao 1, 2 1 School of Chemistry, Beihang University. 2 Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University. Inspired from nature, by mimicing the function of vegetations (such as cacti) which stomata on their leaves would close at relative high temperature to sustain their lives, we fabricate a kind of graphene membrane which pores close at high temperature and open at low temperature 1. Furthermore, we can fabricate thermoresponsive GO membrane with opposite gating regularities, that is, positive gating property and negative gating property. With the increasing mass content of poly(nisopropylacrylamide) in the membrane, the gating ratio of membrane can achieve a reversal from positive to negative 2. This study paves a way to fabricate new type smart nanofiltration membrane and provides effective help for designing controlled molecule separation and drug release materials 3. Key Words: graphene separation membrane, biomimetic, smart, nanochannel [1] Jingchong Liu, NüWang, Yong Zhao, et al. Bioinspired Graphene Membrane with Temperature Tunable Channels for Water Gating and Molecular Separation [J]. Nature Communications, 2017, 8: [2] Jingchong Liu, Li-juan Yu, Yong Zhao, et al. Thermoresponsive Graphene Membranes with Reversible Gating Regularity for Smart Fluid Control [J]. Advanced Functional Materials, 2018, [3] Jingchong Liu, NüWang, Yong Zhao, et al. Bioinspired Membranes for Multi-phase Liquid and Molecule Separation [J]. Science China Chemistry, 2019, 62:

192 4.3 Nanofiber for sensors

193 Colorimetric Sensor Based on Electrospun Fleece for the Identification of the Explosive Triacetone Triperoxide (TATP) Amadeus Janotta 1, Peter Kaul 1 1 University of Applied Sciences Bonn-Rhein-Sieg, Institute of Safety and Security Research, Von- Liebig-Str. 20, Rheinbach, Germany. The peroxide-based explosive triacetone triperoxide (TATP) has a high sensibility to friction, vibration, heat and impact and therefore has neither military nor industrial use. However, since more than a decade this explosive has been used by terrorists to build improvised explosive devices (IED) or homemade explosives (HME) for terrorist attacks because of its simple synthesis and the easy access of raw materials. In this feasibility study a novel electrospun sensor is developed for the colorimetric identification of TATP by the naked eye. The colorimetric reaction of the electrospun fleece is based on the decomposition of TATP with an acid to produce acetone and hydrogen peroxide (H 2 O 2 ) [1]. The H 2 O 2 formed in the TATP decomposition undergoes a reaction with a chromophore (e.g. 3,3,5,5 - Tetramethylbenzidine (TMB)). In this redox reaction with H 2 O 2 as the oxidant and TMB as the reductant, the white colored electrospun fleece changes its color to blue because of a shift in the wavelength. This reaction is usually catalyzed by peroxidases, however, in this study enzyme-mimetic silver nanoparticles (Ag-NPs) [2], so called nanozymes, have been successfully implemented in the polymer matrix which has been uniaxially electrospun. The solution for the polymer matrix consists of four substances ethanol (62.3 wt%), Ag-NPs (22.6 wt%), polyvinylpyrrolidone (13.2 wt%) and TMB (1.9 wt%). First tests with different liquid H 2 O 2 concentrations show strong response with the fleece (Fig. 1). Gaseous H 2 O 2 also showed strong colorimetric reaction with the fleece. Further research in the implementation of liquid acids (coaxial) or solid acids (uniaxial) is in progress. The aim is to use the fleece itself to decompose and to react with TATP in the gaseous phase to induce a color change. Then, it can be used as a quick test of unknown, as TATP suspected potentially high dangerous and volatile powders for security authorities. Fig. 1: Electrospun fleece before and after addition of 4 µl of 5 % H 2 O 2 (left and right picture, respectively) Key Words: Colorimetric sensing, peroxide-based explosive, nanozymes, electrospun fleece [1] Oxley, J. C., Smith, J. L., et al. Factors Influencing destruction of triacetone triperoxide (TATP) [J]. Propellants, Explos. Pyrotech., 2014, 39(2): [2] Bagheri, N., Khataee, A., et al. Visual detection of peroxide-based explosives using novel mimetic Ag nanoparticle/znmof nanocomposite [J]. J. Hazar. Mater., 2018, 360:

194 Electrical conductivity of electrospun PEDOT nanofibers for wearable sensing applications Michael Chung 1, Giuseppino Fortunato 2, Norbert Radacsi 1 1 School of Engineering, Institute for Materials and Processes (IMP), University of Edinburgh, EH9 3FB, United Kingdom. 2 Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, 9014 St. Gallen, Switzerland. Flexible electrodes for wearable sensors require material properties such as large reactive surface area, high electrical conductivity, mechanical flexibility, ductility and biocompatibility for efficient performance and user comfort. There is a potential for these criteria to be fulfilled by electrospinning the conductive polymer poly(3,4-ethylenedioxythiophine) (PEDOT) for fabricating nanofibrous electrodes. As PEDOT cannot be electrospun by itself, it must be electrospun with a carrier polymer or obtained through post-polymerization of the electrospun polymer. Polyethylene oxide (PEO) has been found previously to yield the highest electrical conductivity results when electrospun with PEDOT [1]. An investigation was conducted on the structure of nanofibers for blend electrospinning of PEDOT/PEO versus PEO electrospinning with subsequent oxidative polymerization of PEDOT using the oxidant FeCl 3 6H 2 O in ethanol. It was found from XPS results that blend electrospinning produced a more arbitrary distribution of PEDOT and PEO in the nanofibers while oxidative polymerization produced PEDOT-shell, PEO-core nanofibers. The electrical conductivity for each type of sample was found using Van der Paaw s method and it was concluded that due to the greater control over PEDOT distribution and thickness, the core-shell nanofibers obtained by oxidative polymerization had more efficient electron transfer and hence superior conductivity. Electrospun elastic thermoplastic polyurethane (TPU) was also investigated for subsequent polymerization of PEDOT and the mechanical/electrical properties were characterized. This was found to be potentially useful for wearable sensing where more stretchable sensors are required. Figure 1. (a) Electrospun TPU with oxidative polymerization in EDOT/FeCl 3 6H 2 O/EtOH; (b) SEM image of blend electrospun PEDOT/PEO nanofibers. Key Words: PEDOT, conductive polymer, wearable flexible sensor, oxidative polymerization [1] Zhao W., Yalcin B. and Cakmak M. Dynamic assembly of electrically conductive PEDOT:PSS nanofibers in electrospinning process studied by high speed video [J]. Synthetic Metals, 2015, 203(1):

195 Electrospun nanofiber-based aerogels as adsorbents and improved SERS detection sensitivity Manman Li, Si Cheng * College of Chemistry, Chemical Engineering and Materials Science, Soochow University Suzhou, Jiangsu , China. Aerogels can be widely used due to their large specific surface area, low density and high porosity. In the last few decades, many efforts have been dedicated to developing various aerogel materials including silica, graphene oxide and synthetic polymers so on. [1-2] Among them, the nanofibers obtained by electrospinning have attracted extensive attention due to robust mechanical strength, low density, fine flexibility, extremely high aspect ratio and ease of scalable synthesis from various materials (polymer, ceramic, metal, carbon and so on). Herein, we report polyacrylonitrile (PAN) /Ag nanofiber-based aerogel by combining electrospun nanofibers and the freeze-drying method. The resultant nanofiber-based aerogel exhibit ultralow density (< 20 mg/cm 3 ), superhydrophobic/superoleophilic wettability, and high porosity. Thanks to the advantageous nanostructure, the as-prepared PAN/Ag porous nanofibrous aerogels can efficiently absorb organic solvents and oils in aqueous solution as adsorbents. Meanwhile, the PAN/Ag aerogel exhibits improved sensitivity of SERS detection for the absorbed contaminant due to the decorated noble metal nanoparticles(ag) and the accumulation and concentration effect.. Key Words: aerogels, nanofibers, superhydrophobic, adsorbents, SERS Acknowledgements: This work was supported by the National Natural Science Foundation of China ( , ) and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions. [1] Morris, C. A.; Anderson, M. L.; Stroud, R. M.; Merzbacher, C. I.; Rolison, D. R. Silica Sol as a Nanoglue: Flexible Synthesis of Composite Aerogels. Science 1999, 284, [2] Hu, H.; Zhao, Z.; Wan, W.; Gogotsi, Y.; Qiu, J. Ultralight and Highly Compressible Graphene Aerogels. Adv. Mater. 2013, 25,

196 Freestanding single nanoyarn coated with Au nanoparticles-functionalised conductive polymer for flexible and wearable gas sensors Hamin Shin 1, Dong-Ha Kim 1, and Il-Doo Kim 1 * 1 Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea * Corresponding Author address: Electronic textiles, formed with electrically conductive fibers, are the general basis of wearable technology and smart garment designs. Electrospun nanofibers (NF) can be continuously aligned into a highly ordered form, which can serve as a free-standing structure, i.e. nanoyarn, which exhibits superior strength and higher degree of order than conventional NF mats. The nanoyarn can be easily coated with any material of need, in order to give it a functionality adequate to its application. In this study, highly ordered polyacrylonitrile (PAN) NFs are coated with a well-known conductive polymer, polyaniline (PANI) (Figure 1a, b), to be used as a flexible ammonia-sensing platform. The sensor features a robust thread at the core of the structure, which provides an extra mechanical stability to the yarn, especially upon bending and stretching. Moreover, gold nanoparticles (AuNPs), chemically synthesized on the surface of the PANI coating via facile one-pot synthesis[1], would enhance the ammonia-sensing property of the polyaniline, by acting as catalytic centers[2] and forming Schottky junctions[3]. These merits make our sensor an attractive candidate to be applied in wearable sensors. We demonstrate the outstanding ammonia detection performances of the yarn sensor in a wide range of concentrations (Figure 1c), and the sensor is highly selective towards ammonia when compared to other gases, for example, toluene, nitrogen oxides, acetone, formaldehyde etc. Furthermore, the performance is extremely stable even after repeated bend tests. Figure 1. a), b) SEM images of PAN nanoyarn, very uniformly coated with polyaniline, and c) normalized resistance change versus the concentration of ammonia The abstract should provide a high quality graphic (scheme, figure, or their combination) with an appropriate legend, which serves to attract reader s attention. Please note that the graphic should be in JPG or TIF format with a file size less than 1.0 MB and imbedded (not floated!) at the end of abstract. Key Words: Polyaniline, Ammonia gas sensor, Au nanoparticles, nanoyarn, flexible sensor [1] W. Li, Q. X. Jia, and H.-L. Wang, Facile synthesis of metal nanoparticles using conducting polymer colloids, Polymer (Guildf)., vol. 47, no. 1, pp , Jan [2] Y. Santiago-Rodríguez, J. A. Herron, M. C. Curet-Arana, and M. Mavrikakis, Atomic and molecular adsorption on Au(111), Surf. Sci., vol. 627, pp , Sep [3] C. Liu, H. Tai, P. Zhang, Z. Ye, Y. Su, and Y. Jiang, Sensors and Actuators B : Chemical Enhanced ammonia-sensing properties of PANI-TiO 2 -Au ternary self-assembly nanocomposite thin film at room temperature, Sensors Actuators B. Chem., vol. 246, pp , 2017.

197 Going from polymer to application: ecofriendly solvent electrospinning of optical nanofibrous sensors Ella Schoolaert 1, Richard Hoogenboom 2, and Karen De Clerck 1 1 Department of Materials, Textiles and Chemical Technology (MaTCh),, Faculty of Engineering and Architecture, University of Ghent, Tech Lane Science Park Campus A 70A, 9052 Zwijnaarde, Belgium. 2 Department of Organic and Supramolecular Chemsitry, Faculty of Sciences,, University of Ghent, Krijgslaan S4, 9000 Ghent, Belgium. Today, a world without sensors is unthinkable. Going from smoke to food freshness detectors, we strongly rely on them to warn us whenever something is wrong. In research they gain a lot of interest as we want them to be lighter, faster and smarter. Important is that the sensor signal is easy to interpret. Sensors showing an optical change, e.g., color are the ideal candidates. Nanofibrous membranes possess a high specific surface area which enhances interaction with the environment and are thus very well suited for fast responding and highly sensitive sensor materials. Yet, some important challenges, such as providing stable sensors in an ecological friendly way, still have to be faced. In our work, stimuli-sensitive dyes are applied to provide the optical function. However, dye-leaching, resulting in sensor instability, is currently a major challenge. Our results show that this problem can be tackled by dye-immobilization. The polymer is modified with the dye before or after electrospinning, providing a covalent linkage between both.[1][2] Another important challenge is ecofriendly production. Thermoresponsive polymers showing LCST (lower critical solution temperature) behavior might clear the way for aqueous ( green ) electrospinning. We show that electrospinning from aqueous solvent systems requires special care as the control of ambient parameters, e.g., temperature and relative humidity play a crucial role in the stability of the process and the final nanofiber morphology.[3] By facing these challenges we aim to contribute to the design of optical nanofibrous sensors produced by an ecological friendly process, being of great interest to various application fields, e.g., biomedicine. Figure 7. Thermoresponsive polymer and stimuli-sensitive dye are solubilized in an aqueous solvent system and consequently electrospun under controlled environmental conditions to result in nanofibers reversibly responding to external stimuli by an optical response. Key Words: Aqueous electrospinning, nanofibers, optical sensors, thermoresponsive polymers, stimuli-sensitive dyes. Acknowledgements: Research results were obtained within the framework of the FWO Strategic Basic Research grant 1S05517N. [1] Schoolaert, E., Steyaert, I, et al. Blend Electrospinning of Dye-Functionalized Chitosan and Poly(ε-Caprolactone): Towards Biocompatible ph-sensors [J]. J. Mater. Chem. B, 2016, 4 (26): [2] Schoolaert, E., Hoogenboom, R., et al. Colorimetric Nanofibers as Optical Sensors [J]. Adv. Funct. Mater., 2017, 27 (38): [3] Schoolaert, E., Ryckx, et al. Waterborne Electrospinning of Poly(N-Isopropylacrylamide) by Control of Environmental Parameters [J]. ACS Appl. Mater. Interfaces, 2017, 9 (28):

198 Highly stretchable and durable strain sensor based on carbon nanotubes decorated thermoplastic polyurethane fibrous network with an aligned structure Miaoning Ren, Guojie Li, Wei Zhai, Kun Dai*, Chuntai Liu School of Materials Science and Engineering, The Key Laboratory of Material Processing and Mold of Ministry of Education, Zhengzhou University, Zhengzhou , PR China With the rapid growth of requirements of wearable electronic equipment, electronics with flexibility, stretchability, and body-attachable characteristic have aroused tremendous interests for developing health monitoring and movement detection applications available for interacting with the human body [1-2]. Wearable strain sensors capable of deforming their shapes with a natural motion manner when subjected to mechanical deformation, have attracted a large number of researchers. A satisfactory resistive-type strain sensor with high sensitivity need considerable structural deformations of conductive network under stretching, whereas sensors with high sensing range should be morphologically intact upon large stretching to keep the efficient electrons transport through the conductive paths in the conductive network [1]. While it is still a great challenge to exploit wearable strain sensors with both high stretchability and excellent sensitivity. Here, a facile, cost-effective, and scalable strategy to manufacture oriented carbon nanotubes (CNTs)/ thermoplastic polyurethane (TPU) strain sensors with buckles was developed (Fig. 1). The CNTs/TPU conductive polymer composites were fabricated by electrospinning and ultrasonication. Different tensile properties of CNTs/TPU film in vertical and parallel directions were both investigated in detail. Compared with the random TPU film, the vertically oriented CNTs/TPU film (V-CNTs/TPU) shows an ultra-high stretchability (>800%) and an excellent repeatability at large strains (10,000 cycles at the strain of 200%). Besides, an ultra-low detection limit (strain of 0.5%) has also been achieved. We demonstrate that the CNTs/TPU strain sensor can be efficiently used for detecting the blowing of a balloon and the human motions (Fig. 1). Fig. 1 (a) Real-time relative resistance change on detecting (a) deformation of a balloon and (b) phonation when the tester pronounced different words A, B, C and Hello. Key Words: Electrospinning, Flexible strain sensor, Aligned fibers, Carbon nanotubes, Thermoplastic polyurethane Acknowledgements: The authors gratefully acknowledge the financial support of this work by the National Natural Science Foundation of China (No. U , , ). : [1] Wang Y L, Hao J, Dai K*, et al. Flexible electrically resistive-type strain sensors based on reduced graphene oxide-decorated electrospun polymer fibrous mats for human motion monitoring [J]. Carbon, 2018, 126: [2] Zhou Y J, Zhan P F, Dai K*, et al. Significant stretchability enhancement of crack-based strain sensor combined with high sensitivity and superior durability for motion monitoring [J]. ACS Applied Materials & Interfaces, 2019, 11(7):

199 Hollow Fibers Swimmer Based on Marangoni Effect for Controlled and Continuous Motion Dianming Li, NüWang, Zhimin Cui, Yong Zhao Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, Beijing Key Laboratory of Bioinspired Energy Materials and Devices, School of Chemistry, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, , P. R. China. The rapid response movement caused by Marangoni stress holds considerable promise for diverse future applications. The most convenient and universally applicable approach to form Marangoni effect is concentration gradient; [1, 2] however, long-lasting and controlled motions are rarely reported, currently. The aligned hollow fibers swimmer (AHFS) was fabricated based on Marangoni effect through typical coaxial electrospinning method. By virtue of the design of the aligned hollow microstructure and optimized geometrical shape, the AHFS exhibited a highly controllable motion induced by magnetic field and concentration gradient. Moreover, we design a novel continuous motion system under illumination realizing the conversion from solar energy into mechanical energy. The AHFS shows potential application prospects in controlled load cargoes and convenient energy conversion system. Key Words: electrospinning, hollow fiber, swimmer, surface tension, Marangoni effect [1] Park J H, Lach S, Polev K, et al. Metal-Organic Framework "Swimmers" with Energy-Efficient Autonomous Motility [J]. ACS Nano, 2017, 11(11): [2] Wang L, Yuan B, Lu J, et al. Self-Propelled and Long-Time Transport Motion of PVC Particles on a Water Surface [J]. Advanced Materials, 2016, 28(21): 4065.

200 Luminescent properties and sensing performance of a carbon quantum dot encapsulated electrospun nanofibrous membrane Yipu Zhao, Wanyu He, Tao Guo, Yuyin Wang, Yanan Wu, Yinghao Chen, Xiangpeng Zhang, Jiahao Jue, Shouzhu Li Laboratory of Nanofiber Membrane Materials and Devices, Xinjiang University Institute of Science and Technology, 1 Xuefu Road, Akesu , PR China. The on-spot, rapid and sensitive detection of metal ions has been widely concerned. Although some ion probe molecules were developed, the research on immobilized fluorescent probes for ion are very limited. Herein, this plan studys the fluorescence sensing of silica nanofiber membrane loaded by fluorescent probing molecule for the ion sensing. Carbon quantum dots were loaded in silica nanofiber membrane via sol-gel. The controllable immobilization of nanofiber membrane material and the following effect on fluorescent material performance and its sensitivity for ions were stuided. Besides, the microcosmic fluorescence sensing recognition process was revealed. A carbon quantum dot encapsulated mesoporous silica/polyacrylonitrile (CDs/mesoSiO 2 /PAN) electrospun nanofibrous membrane was prepared via sol-gel. A uniformly distributed mesosio 2 shell on the PAN nanofiber formed with a higher surface area of 25.2 m 2 /g (4.53 m 2 /g of the PAN membrane). After immobilizing into the nanofibers, the excitation and emission peaks of the CDs red shifted. These red shifts were ascribed to the interaction between SiOH and the oxygen-rich groups on the CD surface, which influences the energy traps on the CDs and changes their PL properties. the PL intensity of the CDs decreased significantly as the ph increased from 2 to 12, whereas that of the CDs/mesoSiO 2 /PAN nanofibrous membrane is almost stable across the whole ph range with the fixed emission peak at 440 nm. The intensity change of the CDs may be because of the deprotonation of surface oxygencontaining groups of CDs in alkaline solution, which would influence the PL properties of CDs. Therefore, the luminescence generated from the carbon defect states is retained. The improved photostability of the embedded CDs was because of the passivation of active groups on the surface of CDs due to the potential formation of hydrogen bonds after immobilization. The hydrogen bonding between SiOH and surface oxygen-containing groups of the CDs can also partly hinder the CDs and metal ions at a certain extent leading to lower sensing performance than that of PAN nanofiber. The hydrogen bonding under the conditions of heating can also further form chemical bond leading to a more powerful protective passivation performance than that of PAN nanofiber. This project provides clues for the development of supported fluorescence sensors for ion detection in both theoretical and practical ways. Scheme 1 Preparation of the CDs/mesoSiO 2 /PAN nanofibrous membrane to the detection of Fe(III) Key Words: nanofiber membrane, silica, fluorescent sensing, rhodamine B, carbon quantum dots Acknowledgements: The authors acknowledge financial support from the Western Light Program of the Chinese Academy of Sciences, the National Natural Science Foundation of China ( ). [1] Li S, Zhou S, Xu H, et al. Luminescent Properties and Sensing Performance of a Carbon Quantum Dot Encapsulated Mesoporous Silica/Polyacrylonitrile Electrospun Nanofibrous Membrane. J Mater Sci, 2016, 51:

201 Octahedral SnO2/Graphene Composites with Enhanced Gas-Sensing Performance at Room Temperature Lizhai Zhang 1, Junna Shi 1, Yuhong Huang 2, Huiyan Xu 3, Kewei Xu 2, Paul K. Chu 2, Fei Ma 1 1 State Key Laboratory for Mechanical Behavior of Materials, Xi an Jiaotong University, Xi an , Shaanxi, China 2 Department of Physics and Department of Materials Science and Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China Although high-energy facets on metal oxides are usually active and preferred for gas sensing, it is difficult to expose them according to thermodynamics. In this work, nanocomposites of SnO 2 and graphene are prepared by a hydrothermal method. The SnO 2 nanoparticles morph from a lance shape to an octahedral shape as the concentration of HCl in the solution is increased from 6.5 vol% to 10 vol%. However, the SnO 2 nanoparticles have an elongated octahedral shape if the concentration of HCl is increased further. The octahedral SnO 2 nanoparticles are enclosed by high-energy {221} facet thus facilitating gas sensing. First-principles calculation shows that the surface energy and adsorption energy of the {221} facet are larger than those of the stable {110} facet and so the gas adsorption capacity on the {221} facet is better. Furthermore, since the work function of SnO 2 {221} facet is smaller than that of graphene, electrons are transferred from SnO 2 to graphene enabling effective electron exchange between the composite and external NO 2 gas. The excellent gas sensing properties of the octahedral SnO 2 /graphene composites are ascribed to the high chemical activity of the exposed {221} facet. Figure (a-e) SEM images of five samples; (f) Sensitivity of the SnO 2 /graphene composites a-e to 5ppm NO 2 at K; (g) Selectivity of the SnO 2 {221}/Graphene (Sample c) toward 5ppm NO 2 and 200ppm alcohol, toluene, NH 3, acetone and methanol; (h) Sensitivity of Sample c to 5ppm NO 2 at different temperatures; (i) Stability of Sample c toward 5ppm of NO 2 ; (j) Adsorption energy of different gases on the surface of SnO 2 {221} facets; (k) Adsorption energy of NO 2 on the surface of SnO 2 {110} and {221} facets. Key Words: SnO 2 {221}, graphene, heterojunction, gas sensing Acknowledgements: National Natural Science Foundation of China (Grant Nos and ), Natural Science Foundation of Shaanxi Province (No. 2017JZ015), Hong Kong Research Grants Council (RGC) General Research Funds (GRF) No. CityU , and City University of Hong Kong Strategic Research Grant (SRG) No The authors express gratitude to the Instrument Analysis Center of Xi an Jiao tong University. [1] Han, X. G.; Jin, M. S.; Xie, S. F.; Kuang, Q.; Jiang, Z. Y.; Jiang, Y. Q.; Xie, Z. X.; Zheng,L. S. Synthesis of Tin Dioxide Octahedral Nanoparticles with Exposed High-Energy {221} Facets and Enhanced Gas-Sensing Properties. Angew. Chem. 2009, 121,

202 Synthesis of Pt decorated MXene nanomaterials for NO 2 gas sensing Soohwan Chae 1, Dong-Ha Kim 1, Ji-Soo Jang 1, Won-Tae Koo 1, and Il-Doo Kim 1 1 Department of Materials Science and Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. MXene is a new type of 2D material that has recently been actively studied. Ti 3 C 2 T x is the first and most studied MXene substance. Ti 3 C 2 T x can be synthesized by etching Al at Ti 3 AlC 2 in various ways.[1] With very high electrical conductivity and hydrophilicity, research is being done in various fields such as energy storage, EMI shielding, catalyst, sensor, and filter.[2] In particular, there have been some recent studies using MXene as a chemiresistive gas sensor.[3] When Ti 3 C 2 T x was used as a sensing material, it was able to detect gases such as acetone, ethanol, and ammonia at room temperature. However, low sensitivity and selectivity were unsolved. So in this study, we tried to solve the problem by attaching Pt nanoparticles to the surface of Ti 3 C 2 T x. As a result, samples with Pt nanoparticles could selectively detect nitrogen dioxide (NO 2 ) gas at room temperature and improve sensitivity. It also confirmed that NO 2 sensitivity was maintained at 70. It may be due to the activation of NO 2 gas molecules by Pt metal and the spill-over of NO 2 - on the Ti 3 C 2 T x surface. As a result, using MXene as a gas sensor, it sensed harmful NO 2 gas not only to the environment but also to humans, and it improved its sensitivity and selectivity by using Pt nanoparticle catalyst. Figure 8. Gas response performance of Ti 3 C 2 T x sensors. Resistance change upon exposure to 5 ppm of acetone, ethanol, ammonia at room temperature (25 ), and NO 2 at various temperature. Key Words: Gas sensing, MXene, NO 2 sensor, 2D materials, Ti 3 C 2 T x [1] Alhabeb M, Maleski K, Anasori B, et al. Guidelines for Synthesis and Processing of Two- Dimensional Titanium Carbide (Ti 3 C 2 T x MXene) [J]. Chem. Mater., 2017, 29(18): [2] Anasori B, Lukatskaya M R, Gogotsi Y. 2D metal carbides and nitrides (MXenes) for energy storage [J]. Nat. Rev. Mater., 2017, 2: [3] Kim S J, Koh H J, Ren C E, et al. Metallic Ti 3 C 2 T x MXene Gas Sensors with Ultrahigh Signal-to- Noise Ratio [J]. ACS Nano, 2018, 12(2):

203 4.4 Characterization of nanofibrous materials

204 Fabricating Porous Poly(lactic acid) Fibres via Electrospinning C Huang 1 and N L Thomas 2 1 Department of Materials, Loughborough University, Ashby Road, Loughborough, Leicestershire, LE11 3TU, UK. 2 Department of Materials, Loughborough University, Ashby Road, Loughborough, Leicestershire, LE11 3TU, UK. In this abstract, amorphous poly(lactic acid) (PLA), a biodegradable polymer with excellent biocompatibility, is successfully electrospun into micron-sized fibres with controlled surface and internal morphologies. By careful solvent selection, either surface porosity or internal porosity can be achieved through different mechanisms. Use of chloroform as the solvent gives rise to circular pores of 100 nm diameter confined to the surface. These are obtained in humid conditions by the so-called Breath Figure mechanism. It is found that combining chloroform with a water-miscible non-solvent yields either surface porosity (wrinkled effect) using a low boiling point liquid, e.g. ethanol, or internal porosity using a high boiling point liquid, e.g. dimethyl sulphoxide (DMSO). Both these microstructures are obtained through a non-solvent induced phase separation (NIPS) mechanism. Finally, it is found possible to produce both surface and internal porosity using DMSO by a vapour induced phase separation (VIPS) mechanism. The porous electrospun PLA mats were shown to exhibit significantly increased oil absorption capacity compared with the non-porous fibre mats [1]. Key Words: Electrospinning, Porosity, Poly(lactic acid), PLA, Mechanisms. Acknowledgements: The authors are grateful for funding for this work and provision of laboratory facilities from the Department of Materials, Loughborough University, UK. Also they would like to acknowledge technical assistance from Dr Keith Yendall for scanning electron microscopy (SEM) and Dr Elisa Mele for helpful discussions. [1] C. Huang, N.L. Thomas, Fabricating Porous Poly(lactic acid) Fibres via Electrospinning, European Polymer Journal, 2018, 99:

205 Thermal Conductivity ( W/mK ) Enhanced Thermal Conductivity of Electrospinning Nanofibers Jian Ma 1, Lei Zhou 1, Jingwen Mo 1 Jiangsu Key Laboratory for Design and manufacture of Micro-Nano Biomedical Instruments, School of Mechanical Engineering, Southeast University, Nanjing, , China. In this study we explore the relation among the electrospinning voltage, resulted nanofiber structure, and the corresponding thermal conductivity. Results show that electrospun PE nanofibers exhibit thermal conductivity that can be significantly higher than bulk values (~0.4 W/m-K), with the highest value measured as 9.3 W/m-K. This thermal conductivity enhancement is due to the higher degree of molecule orientation and enhanced level of crystallinity, as evidenced by the micro-raman spectroscopy characterization. A general trend of higher thermal conductivity with larger electrospinning voltage was observed; however, it is also found that the thermal conductivity for fibers prepared with the same voltage could vary significantly, likely due to the whipping instability in the electrospinning process. Given that electrospinning is a quick and low cost process to produce nanofibers with enhanced thermal conductivity, this study points to the potential of electrospun polymer nanofibers as materials with good thermal transport properties. a IR-heater PE solution Syringe pump High Voltage b c d 12 9 kv 145nm 13 kv 130nm 16 kv 95nm 19 kv 65nm 21 kv 96nm 31 kv 99nm 34 kv 45nm 45 kv 53nm HDPE nm Temperature ( K ) a. Schematic steps of electrospinning PE nanofiber. b is the optical image of the laser focused on individual PE nanofiber for Raman measurement. c is the SEM image for thermal conductivity measurement. d. Thermal conductivity of PE nanofibers. Key Words: Electrospinning, Polyethylene Nanofibers, Thermal conductivity Reference: [1] Ma J, Zhang Q, Mayo A et al. Thermal conductivity of electrospun polyethylene nanofibers [J]. Nanoscale, 2015, 7(40):

206 Electrospun cellulose nanocrystals/poly(methyl methacrylate) composite nanofibers: Morphology, thermal and mechanical properties Dong Wang, Xiaohui Ni, Qingxiang Wang, Wanli Cheng, and Guangping Han* 1 Key Laboratory of Bio-based Material Science and Technology (Ministry of Education), Northeast Forestry University, , Harbin, China. An electrospinning process was utilized to fabricate composite nanofibers of poly(methyl methacrylate) (PMMA) reinforced with cellulose nanocrystals (CNCs). The effect of environmental relative humidity on the microstructure of CNC/PMMA nanofibers was investigated. Results showed that fiber surfaces of CNC/PMMA appeared smooth. Fibers had gradually decreasing diameters and lower diameter variations as CNC loading increased. The thermal property of CNC/PMMA nanofibers was also enhanced due to hydrogen bonding between PMMA molecular chains and CNC nanoparticles. Compared to pure PMMA fibers, the storage modulus and tensile strength of composite nanofibers were pronouncedly improved. By increasing relative humidity of the electrospinning environment, these nanofibers showed prominent nanoporous surfaces while the surface roughness and porosity of CNC/PMMA nanofibers increased. Furthermore, CNCs were critical to accelerating the evolution of pores and increasing surface roughness. Our findings can provide useful guidelines for the fabrication of nanofibers with desired properties and pore structure by electrospinning. Key Words: Cellulose nanocrystals; Poly(methyl methacrylate); Electrospinning; Relative humidity; Mechanical property Acknowledgements: This work is supported by the National Natural Science Foundation of China (Gant No ). [1] Ni X, Cheng W, Huan S, et al. Electrospun cellulose nanocrystals/poly (methyl methacrylate) composite nanofibers: Morphology, thermal and mechanical properties[j]. Carbohydrate polymers, 2019, 206:

207 The effect of competitive behavior on centrifugal electrospinning Hengwei Hu 1,Kaili Li 1, Yong Liu 2 1 College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing , China. 2 College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing , China. Centrifugal spinning, first inspired by a cotton candy machine, is an attractive method for producing nanofibers at high speed and low cost 1. Centrifugal electrospinning combines the advantages of both centrifugal spinning and electrospinning, and can efficiently prepare nanofibers with controlled morphology. It is the development direction of nanofibers preparation technology 2,3. However, the relationship between centrifugal force and electrostatic force, the most important factors in spinning process, are unclear although the two forces were the most important factors in centrifugal electrospinning. To promote the development of the new method, In this research, the game competition behavior between the centrifugal force and the electrostatic force two factors as well as the influence of the behavior of the game behavior on the nanofibers trajectory, diameter and productivity were studied. In this study, we conducted a primary exploration on the effects of the process parameters of the new spinning way on as-spun fibers. PVP was utilized as raw material. The game behavior between centrifugal force and electrostatic force affecting on the fiber morphology, flying trace, fiber diameter, and the productivity were studied. The experimental results showed a new distribution characteristic of the fiber. And the fiber diameter decrease with the increase of the voltage and the speed. However, there is an optimal voltage, in which condition the fiber diameter would be the minimum. Furthermore, when the voltage was 40 kv, the fiber productivity was 2.36 g min -1, which is hundreds to thousands of times higher than traditional electrospinning of g h -1. Fig.1 Nanofibers SEM and fiber diameter distribution when the rotation speed was 1500 rpm (A1 - A6) and Jet formation of centrifugal spinning (B). Key Words: centrifugal electrospinning, PVP nanofibers, jet path, productivity Acknowledgments: This research was funded by the National Natural Science Foundation of China ( ). : [1]. SARKAR K, GOMEZ C, ZAMBRANO S, et al.electrospinning to forcespinningtm[j].materials Today, 2010, 13 (11) : [2]. GAO H S.Research development in electrospinning technique for manufacturing nanofibers and progress on their apparatus[j].materials Review, 2017, 26 (s2) : (in Chinese). [3]. MA X L, ZHANG L Y, LI H Y, et al.preparation of oriented nanowires by melt differential electrospinning[j].journal of Textile Research, 2017, 38 (1) :8-12. (in Chinese).

208 Determination of microstructural properties of electrospun polyurethane membranes Karel Soukup, Vladimír Hejtmánek, Olga Šolcová Institute of Chemical Process Fundamentals of the CAS, v. v. i., Rozvojová135, CZ Prague 6, Czech Republic, Currently, several polymers have been applied as membranes for tissue engineering applications. However, polyurethane is one of the best candidate due to its mechanical properties, flexibility and biocompatibility [1]. Polyurethane nanofibers can be generally prepared using a number of different techniques including e.g. phase separation, templating, drawing, or vapor phase polymerization; however, the electrospinning method represents not only the simplest but also the cheapest way for production of nanofibers even at industrial scale [2]. Electrospinning process was performed with an automated setup given in Fig. 1. It consists of a steel rotation spinning electrode with the stainless steel needles. The stainless steel grounded cylinder was utilized as a collecting electrode. High-voltage DC power supply (Matsusada, Japan) was used for evaluation of the desirable electric field strength between the tip of spinneret electrode and grounded collector surface. Prepared membranes were post-electrospinning processed by the hotpressing method (pressing power of 600 kn/m 2 and temperature corresponding to 80 o C) using 2 mm thick individual and 2 sheets of 1 mm thick electrospun nanofibrous layers, respectively. Fig. 1 Electrospinning setup The morphology, texture characteristics and transport properties of the prepared nanofibrous mats were detailed investigated. On the basis of the texture results it was confirmed that prepared polyurethane nanofibrous mats contain macroporous structure without micro- as well as mesopores. Gas transport measurements performed in Graham s diffusion cell and permeation cell show very low transport resistance; however, the corresponding transport parameters were evaluated with the sufficiently high reliability. It was confirmed that the gas transport in porous network of electrospun mats takes place predominantly by means of the bulk diffusion and viscous flow mechanism while Knudsen mechanism is negligible. Key Words: polymeric nanofibrous membranes, electrospinning, transport phenomena, Graham`s diffusion cell, permeation cell Acknowledgements: The financial support of the Technology Agency of the Czech Republic (projects No. TE and TN /05) is gratefully acknowledged. : [1] Gabriel L. P., Rodrigues A. A., Macedo M., et al. Electrospun polyurethane membranes for Tissue Engineering applications [J]. Materials Science and Engineering: C, 2017, 72: [2] Web site of Elmarco Company [W]:

209 Encapsulation of Phycocyanin by Polysaccharide-based Electrospun Fibers and Improved Colon Cancer Prevention Effects Peng Wen 1, Yan Wen 1, Teng-Gen Hu 1, Kun Feng 1, Yun-Shan Wei 1, Min-Hua Zong 1, Hong Wu 1 1 School of Food Science and Engineering, South China University of Technology; Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Guangzhou , China Introduction Colon cancer is one of the most common worldwide health threats. Phycocyanin (PC) has prevention potential against colon cancer, however, its poor stability and low bioavailability limits its beneficial effects. Colon targeted delivery is regarded as an attractive option as it can result in higher specificity, improved efficacy and the reduced adverse effects, especially, polysaccharides have gained much attention in developing such microflora-activated colon specific release systems 1. Studies have shown that the use of a combination of polysaccharides can be more effective for achieving colon-specific delivery compared to the use of a single polysaccharide 2. Coaxial electrospinning has emerged as an efficient and promising approach for targeted delivery of bioactive agents 3. Different dissolution and targeted release behavior for encapsulated bioactives can be achieved by selectively using different core or the sheath components. Herein, the polysaccharidebased microbially responsive electrospun fiber mat (EFM) containing PC for colon cancer prevention was prepared and characterized. Research design In this work, firstly, PC was encapsulated into chitosan nanoparticle (PCNP) and its physiochemical characterization was assessed. Then, co-axial electrospinning was employed to fabricate the PC-loaded electrospun fiber mat (PC-loaded EFM) using SA as shell part for retard release of PC in gastric acid and the PCNP as the core part for the controlled and targeted release of PC. The release behaviour of PC from the core-sheath PC-loaded EFM in vitro and analyzed the colon-specific release mechanism by establishing corresponding mathematics model were also tested. Moreover, the effects of PC-loaded EFM on the prevention of colon cancer cell growth and apoptosis on HCT116 cells were examined. Results and discussion An effective colon targeting system for the controlled release of PC was developed by co-axial electrospinning. Owing to the protective effect of electrospun fibers, the antioxidant activity of released PC after in vitro digestion was also observed, as well as the colon-specific release property. The obtained PC-loaded EFM can inhibit the HCT116 cell proliferation through cell cycle arrest at G/G1 phase and the induction of apoptosis. The probable apoptosis mechanism involved is mediated by the mitochondrial pathway, which is relevant to stimulating the activity of caspase-3, decreasing the rate of Bcl-2/Bax and the release of cytochrome c. The obtained delivery system could be potentially exploited as good candidates for the targeted and sustained delivery of bio-protein/peptides to the colon for cancer prevention. Key Words:coaxial electrospinning; phycocyanin; cancer prevention Fig1. Colon specific delivery of PC for cancer prevention based on coaxial electrospinning. : [1] Zhang, T, Zhu, G, Lu, B, et al. Oral Nano-Delivery Systems for Colon Targeting Therapy [J]. Pharmaceutical nanotechnology, 2017, 5 (2), [2] Kotla, N G, Rana, S, Sivaraman, G, et al. Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives. Advanced Drug Delivery Reviews, DOI: /j.addr [3]Yang, C, Yu, D.-G, Pan, D, et al. Williams, G. R., Electrospun ph-sensitive core shell polymer nanocomposites fabricated using a tri-axial process. Acta Biomaterialia, 2016, 35,

210 Study on AgNPs modified FK/PVA nanofibers by electrospinning Wenjie Chen, Jiao Ding, Guoqiang Yin * College of Chemistry and Chemical Engineering,Zhongkai University of Agricultural and Engineering,Guangzhou ,China. Abstract: Water-soluble surface modified silver nanoparticles were synthesized by liquid phase reduction with polyvinyl pyrrolidone (PVP) as the surface modification and were used to modify FK/PVA nanofibers by electrospinning. The properties of FK/PVA nanofibers modified by AgNPs was researched by exploring the transformation of the microstructure, thermal stability, mechanical property and antibacterial property of AgNPs modified FK/PVA nanofibers before and after modification. The results showed that FK/PVA nanofibers modified by AgNPs have uniform diameter and no beads, and The results showed that the diameter of FK/PVA nanofibers was uniform with the addition of AgNPs, and the average diameter of FK/PVA nanofibers decreased with the increase of AgNP content. The TEM showed that AgNPs were uniformly embedded on the surface of FK/PVA nanofibers during the electrospinning process. The thermal property of the FK/PVA nanofibers modified by AgNPs was improved, and their mechanical property was increases first and then decreases with the increase of AgNPs content. Moreover, the results of bacteriostatic test showed that the FK/PVA nanofibers modified by AgNPs had good bacteriostatic properties, and the inhibitory effect on Staphylococcus aureus was obviously better than that on Escherichia coli. Key Word: Feather keratin; Electrospinning; nano-modification; Antibacterial Acknowledgements: We would like to thanks to the Science and Technology Plan Project of Guangzhou City (grant NO ) and the Guangdong Province Science and Technology Plan (grant No.2017B ) for funding this work. Figure 9 the preparation flow of AgNPs modified FK/PVA nanofibers by electrospinning Figure 10 The samples' TEM diagram (a) AgNPs (b) AgNPs modified FK/PVA nanofibers

211 Preparation and Characterization of electrospun nylon 66 nanofiber/cbt composite Minju Lee 1, Su-Hyeong Chae 1, Taewoo Kim 1, Weidong Han 1, Hak yong Kim 1,2 1 Department of BIN Convergence Technology, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeollabuk-do, , Republic of Korea, 2 Department of Organic Materials & Fiber Engineering, Chonbuk National University, 567 Baekjedaero, Deokjin-gu, Jeonju, Jeollabuk-do, , Republic of Korea Nylon 66 has outstanding strength, toughness, and wear resistance. So, it is considered the important industry significantly. Nylon 66/CBT composites that are optically transparent and have enhanced mechanical strength can broaden the range of applications. In this study, nylon 66/CBT composites were prepared by electrospinning and thermal pressing. And then their optical and mechanical properties were studied. The improvement of the mechanical and optical properties of composites shows that the strategy presented in this study can be applied to various forms such as transparent substrates in various fields such as electronic devices, flexible display, solar cells, etc. Figure. Mechanical and Optical properties of Nylon 66/CBT composite Key Words: electrospinning, thermal pressing, transparent, composite Acknowledgements: (optional, Times New Roman, Size 11, regular font ) (required, maximum three references, Times New Roman, Size 11, regular font, reference format according to Journal of Donghua University, English Edition). For example: [1] B. Pant, H. R. Pant, D. R. Pandeya, G, Panthi, K.T. Nam, S.T. Hong, C.S. Kim, H.Y. Kim. Charaterization and antibacterial properties of Ag NPs loaded nylon-6 nanocomposite prepared by one-step electrospinning process [J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2012, 395(5): [2] J.H. Kim, M. Kataoka, Y.C. Jung, Y.-I. Ko, K. Fujisawa, T. Hayashi, Y.A. Kim, M. Endo, Mechanically Tough, Electrically Conductive Polyethylene Oxide Nanofiber Web Incorporating DNA-Wrapped Double-Walled Carbon Nanotubes [J]. ACS Appl. Mater. Interfaces, 2013, 5(10) : [2] S. Jiang, G. Duan, H. Hou, A. Greiner, S. Agarwal, Novel Layer-by-Layer Procedure for Making Nylon-6 Nanofiber Reinforced High Strength, Tough, and Transparent Thermoplastic Polyurethane Composites [J]. ACS Appl. Mater. Interfaces, 2012, 4(8) :

212 Preparation of Electrospun PAN Based Carbon Nanofibers with Improved Mechanical Properties Su-Hyeong Chae 1, Taewoo Kim 1, Minju Lee 1, Weidong Han 1, Hak Yong Kim 1, * a Department of BIN Convergence Technology, Chonbuk National University, Jeonju, , Republic of Korea. Electrospinning is one of the most popular and attractive methods for fabricating uniform ultrafine fibers with diameters ranging from a few nanometers to several micrometers. In this study, we explored the relationship between the morphology and mechanical properties of electrospun Polyacrylonitrile (PAN) based carbon nanofiber before and after immersing in water. The obtained PAN nanofiber from this particular method shows high mechanical strength and high modulus nanofibers. The results designate substantial enhancement of mechanical strength of PAN nanofiber to offer some assistance to future developments in the area of high-performance electrospun fibers. Key Words: Electrospinning, Polyacrylonitrile, Carbon nanofiber; Mechanical Properties Acknowledgements: This research was supported by Global Ph.D Fellowship Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No ). This research was also supported by Applied Materials Institute for BIN Convergence. [1] Q. Ouyang, L. Cheng, H. Wang, K. Li, Mechanism, and kinetics of the stabilization reactions of itaconic acid-modified polyacrylonitrile, Polym. Degrad. Stab. 93 (2008) [2] M. Park, Y. Choi, S.Y. Lee, H.Y. Kim, S.J. Park, Influence of electron-beam irradiation on thermal stabilization process of polyacrylonitrile fibers, J. Ind. Eng. Chem. 20 (2014) 1875 [3] Y. Choi, M. Park, H. Kyoung Shin, Y. Liu, J.W. Choi, R. Nirmala, S.J. Park, H.Y. Kim, Facile stabilization process of polyacrylonitrile-based electrospun nanofibers by spraying 1% hydrogen peroxide and electron beam irradiation, Mater. Lett. 123 (2014)

213 High-resolution nanofiber patterning using droplet-jet mode near-field electrospinning Dongwoon Shin 1, Jonghyun Kim 1, and Jiyoung Chang 1 1 Department of Mechanical Engineering, University of Utah, Salt Lake City, UT 84112, United States of America. Near-field electrospinning was developed to deposit a nanofiber controllably by eliminating the bending instability phenomenon [1], and many new applications have been realized using the nearfield electrospinning [2]. However, the current state-of-the-art using near-field electrospinning has not achieved intricate and complex patterns in microscale resolution. Herein, we established a droplet-jet mode near-field electrospinning (DJ-NFES), where a single nanoscale fiber can be direct-written with a less than 300 m jet-travel-distance to improve the patterning resolution to microscale. To improve patterning resolution, a jet-travel-distance comparable to the desired pattern size is essential. However, a cone-jet mode, known to be the most stable, inevitably creates a large initial flow, thus comparably long jet-travel-distance is required to ensure deposition of fiber in nanoscale [3]. As a result, tangled microscale fibers are deposited when the cone-jet mode is used in the short jet-travel-distance as shown in Fig. 1A-B. On the other hand, in the droplet-jet mode, the sphere-shape droplet instead of the cone-shape was formed and able to eject the nanoscale jet through the microscale Taylor cone at the surface of the droplet as shown in Fig. 1C. The microscale Taylor cone was able to attenuate the jet into the nanoscale, which allows a successful deposition of a single nanofiber with a cylindrical crosssection in the short jet-travel-distance as shown in Fig 1D. In conclusion, a DJ-NFES was established for the direct-writing of a single nanofiber in microscale. Using DJ-NFES, precise nanofiber patterns in microscale were successfully demonstrated as shown in Fig. 1E-F. In the final presentation, potential applications in the various field of science and engineering utilizing the precise microscale patterning of nanofiber will be presented and discussed. Key Words: Direct-writing, Patterning, Near-field electrospinning, Droplet-jet mode [1] Sun D, Chang C, Li S and Lin L 2006 Near-Field Electrospinning [2] He X-X, Zheng J, Yu G-F, You M-H, Yu M, Ning X and Long Y-Z Near-Field Electrospinning: Progress and Applications [3] Helgeson M E, Grammatikos K N, Deitzel J M and Wagner N J 2008 Theory and kinematic measurements of the mechanics of stable electrospun polymer jets Polymer (Guildf)

214 Development of an automated segmentation algorithm for DiameterJ Magnus Kruse 2, Oliver Rippel 1, Tobias Muckelberg 1, Dorit Merhof 1, Thomas Gries 2, Andreas Blaeser 2 1 Institute of Imaging & Computer Vision, RWTH Aachen University, Germany 2 Instiut fuer Textiltechnik der RWTH Aachen University, Otto-Blumenthal-Straße 1, Aachen, Germany. Introduction Electrospinning is used in different applications (e.g. filtration, tissue engineering, etc.) in form of nonwoven structures to substantially improve the functionality of the products. The important key parameters in the quality control of the produced fiber sheets are diameter, orientation, fiber length, fiber area and mesh hole size. These parameters can be analyzed with an open source plugin for ImageJ called DiameterJ. 1 The main disadvantage of the plugin at the moment is the manual selection of the best segmentation mask out of a set of provided candidates. This leads to a high userdependency of the results. Therefore, the aim of this study is to develop a tool which automatically generates/determines a suitable segmentation mask for analysis, eliminating the aforementioned user dependency. Experimental Setup In order to develop an automated segmentation algorithm, a dataset of 160 pictures generously provided by Bioinicia SL, Valencia, Spain containing different types of electrospun fibers was utilized. For each picture, 24 candidate segmentations were generated automatically using DiameterJ. The 24 candidates where then subsequently utilized to train a Deep Learning based segmentation algorithm of U-Net architecture in a 5-fold cross-validation with validation and test set. Here, different ways to utilize the 24 candidates for training in a weakly-supervised setting were compared against each other. For ground truth, the manually perceived best segmentation mask was determined for all 160 pictures out of all the candidates by 3 experts. As ultimately segmentation is a means to an end, the extracted parameters diameter, orientation and fiber length were compared for the developed algorithm with the best segmentation masks and manual measurements. Results and Discussion By training a U-Net in a weakly supervised setting, segmentation results appropriate for subsequent analysis by DiamterJ could be generated. In order to quantify the impact of the user-dependency of the results, inter rater agreement was assessed. Analysis revealed the segmentation provided by the Deep Learning approach to have the closest agreement to the manual measurements. Therefore, the automated segmentation presented in this work is fit for usage, reducing the user-dependency of the results. Conclusion We successfully developed and presented an approach to automatically segment electrospun fibers in many different settings, eliminating the operator influence on the quality control via DiameterJ. Thus, comparability of quality control could be improved significantly. Key Words: ImageJ, DiameterJ, automatized, fiber, measurement [1] Hotaling NA, Bharti K, Kriel H, Simon Jr. CG. DiameterJ: A validated open source nanofiber diameter measurement tool. Biomaterials 2015;61: doi: /j.biomaterials

215 4.5 Electrospin technical

216 Exploration on technology of polyester fabric composited with waterproof and moisture permeable PVDF nano fibre membranes Chunhui Liu 1, Yanyan Chu 1,2, Jianxin He 1,3, Chunhui Ma 1, Chenghui Kong 1, Xi Liao 1, and Li Li 2 1 Zhongyuan University of Technology Textile Institute, Zhengzhou, Postal Code ,The China. 2 Henan Fibre Inspection Bureau, Zhengzhou, Postal Code 50000, The China. 3 Collaborative Innovation Center of Textile and Garment Industry, Zhengzhou, Postal Code , The China.) Abstract:With the advantage of water repellency and high-porosity of PVDF nano-fibre membrane spun by electrospun [1], it is novel to develop polyester fabrics with such membrane for water repellency,breathability and moisture permeability. In this paper, the effects of concentration of spinning solution and voltage are investigated on the morphology of PVDF nano-fibre membrane. On this basis, heat-press process was applied to bond polyester fabric [2] and the PVDF membrane together with three bonding methods including one membrane on single side, two layers of membrane on single side and two layers of membrane on two sides. The quasi contact angle and dynamic contact angle after those three processes were measured. In addition, mechanical properties, breathability and moisture permeability were also taken into consideration. The results showed that the homogeneity of the fibre diameter ( nm )and the evenness of the membrane would be obtained at the concentration of 23% for spinning solution and the voltage of 15 KV. The instantaneous contact angle was 135.1º, 142.4ºand 136.7ºfor the three combined methods, respectively, where contact angle for the fabric with one membrane on single side reduces 5.40% in eight minutes while that the other two decrease more than 10%. The mechanical property of the compounded fabric is improved by 7.78%, but the breathability and moisture -permeability of it are decreased, approximately 35% and 6.9% individually. Figure 1.Preparation of Waterproof and Moisture Permeable Film of Electrospun Nanofibers Keywords: Poly vinylidene fluoride(pvdf), Nano-fbire, Polyester,Water proof, Breathability and moisture permeability [ 1 ] WANG S, LIU Q, ZHANG Y, et al. Preparation of a multifunctional material with superhydrophobicity, superparamagnetism, mechanical stability and acids bases resistance by electrospinning[j]. Applied Surface Science, 2013, 279(32): [ 2 ] HUO R, GU Z, ZUO K, et al. Preparation and properties of PVDF-fabric composite membrane for membrane distillation[j]. Desalination, 2009, 249(3):

217 Electrospinning Instruments and Accessories Qinyou Jiang 1,and Qimeng Quan 1 Department of Marketing, Shanghai Tarkee Biotechnology Company Limited, Postal code ,No.1258 Building 4 F1 Xinzhu Road Minhang District,Shanghai,China. Various Electrospinning Instruments with all kinds of functions,such as temperature control, humidity control,aqueous spinning,conjugate spinning. 3D printer with a melt nozzle special for biological tissue engineering.it also can be used to XY platform. There are many accessories that can be combined. Different parameters can be selected for inner and outer diameters of coaxial needles. The maximum temperature of melting nozzle can be to 260.The diameters of collector can be selected. Temperature control tank can be uesed outside.steel ring is used to press film in 24-well culture plate.other accessories can be customized according to requirement. Key Words: Electrospinning Instruments, Melt nozzle, XY Platform, Steel ring, Customized Acknowledgements:

218 Development of Mass Production Technology of Two-Component Nanofibers: Centrifugal Electrospinning Taewoo Kim 1, Su-Hyeong Chae1, Min-Ju Lee 1 and Hak-Yong Kim 1,2,* 1 Department of BIN Convergence Technology, Chonbuk National University, Jeonju , Republic of Korea 2 Department of Organic Materials and Fiber Engineering, Chonbuk National University, Jeonju , Republic of Korea Production of two-component nanofibers using a general electrospinning device requires a lot of time and cost due to the very low feed rate of 0.01 ml min-1 and high unit price. Through this study, the centrifugal-electrospinning device succeeded in mass-production of two-component nanofibers at a feed rate of 1 ml min-1 by applying centrifugal force and electrostatic force to the scaled-up tube. It is possible for mass production of two-component nanofibers that are 100times improved than the general electrospinning devices. The prepared two-component nanofibers were characterized by SEM and TEM. Heat generation performance was confirmed by a heating test Figure. Centrifugal - Electrospinning device illustration Key Words: Centrifugal force, Electrospinning, Mass production, Carbon nanofiber

219 Preparation of polyurethane electret nanofiber window screen and its air filtration performance MengYing Li 1,WeiLi Shao 1,2, Fan Liu 1,2,Chun Huiliu 1,Xi Liao 1, and YiMin Zhang 1 1 Zhongyuan University of Technology Textile Institute, Zhengzhou, Postal Code ,The China. E- 2 Collaborative Innovation Center of Textile and Garment Industry, Henan Province, Zhengzhou , China.) Abstract: A great deal of pollution has been produced because of human activities(such as transportation, industry and tree cutting).pm2.5 in the air has become one of the most serious air problems threatening public health. Considering that people spend nearly 90 percent of their time indoors, reducing the concentration of PM2.5 that enters the room could be a way to reduce overall exposure and health effects. Therefore, a new type of electret PU- Si 3 N 4 electret nanofiber anti-haze window screen has been developed. The excellent elasticity of PU render its shape variable to 256% and its breaking strength to be 17.06MPa. In contrast to existing fibrous materials (e.g. fiberglass, Melt-blown fiber, and spun-bonded fiber). Due to their micron fiber diameter and large pore size, they cannot capture PM2.5 efficiently. So electret nanofibers have huge advantages. Under the action of space charge and polarization charge, PU-Si 3 N 4 can achieve a filtration efficiency of 76.3% and a resistance of 30Pa at a low weight of 1.32g/m2 and an air flow rate of 0.053m/s. We expect that this electret polyurethane nanofiber will have a great application in window screen. Figure1. Mechanism diagram of electret nanofiber filtration Figure 2. Filtration performance Key words: electrostatic spinning, electret, filtration efficiency [1] Li X, Wang N, Fan G, et al. Electreted polyetherimide-silica fibrous membranes for enhanced filtration of fine particles[j]. J Colloid Interface Sci, 2015, 439: [2] Shi S, Bian Y, Zhang L, et al. A method for assessing the performance of nanofiber films coated on window screens in reducing residential exposures to PM2.5 of outdoor origin in Beijing.[J]. Indoor Air, 2017, 27.

220 The Properties of Polyacrylonitrile (PAN)/ZIF-67 Composite Porous Separator for Lithium ion Battery Linya Qi 1, Rong Qiang 1 Jianxin He 1,2, Wen Yu, Pingping Yuan, Chunhui Liu 1 Henan Provincial Key Laboratory of Functional Textile Materials, Zhongyuan University of Technology, Zhengzhou , China. 2 Collaborative Innovation Center of Textile and Garment Industry, Henan Province, Zhengzhou , China. Abstract:The separator is a crucial part of lithium ion battery to prevent internal short-circuit and provide ionic conductive path. The conventional separator has low thermal stability and poor electrolyte wettability. ZIF-67 is a new kind of porous material which is composed of metal ions and organic ligands. In this paper, polyacrylonitrile (PAN)/ZIF-67 porous separator is proposed to solve the problems of poor thermal stability and low infiltration of lithium ion battery separator. Combining high porosity and adjustable structure of ZIF-67 material with polyacrylonitrile (PAN) with excellent heat resistance and high melting point. The PAN/ZIF-67 composite was prepared by electrostatic spinning technology showed excellent properties far beyond that of raw materials. Compared with the traditional commercial Celgard separator, the electrolyte infiltration and thermal stability of PAN/ZIF- 67 composite separator are significantly improved, and the electrochemical performance of the battery is significantly enhanced. Figure 1. Schematic representation of the fabrication procedures for separator. Keywords: Lithium ion battery separator, ZIF-67, polyacrylonitrile, electrochemical performance [1] Pan Chen, Jianxing Shen, Tailin Wang, Meng Dai, Conghui Si, Jixun Xie, Min Li, Xiaotong Cong, Xiao Sun. Zeolitic Imidazolate Framework-67 Based Separator for Enhanced High Thermal Stability of Lithium Ion Battery [J]. Journal of Power Sources, 2018, 400(2018):

221 The Fabrication of Flexible Dual-channel Nanofibers Shuai Li 1, Zhimin Cui 1, NüWang 1, Yong Zhao 1 Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, Beijing Key Laboratory of Bioinspired Energy Materials and Devices, School of Chemistry, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, , P. R. China. Multichannel structures are ubiquitous in nature. For example, there are a large number of parallel ducts and sieve tubes in the plant stem and rod, which can deliver water and nutrients for the plants. The structure of the polar bear s hair is also hollow inside, which can play a good role in insulation. In this paper, flexible micro-nano double channel fibers were prepared by multi-channel electrospinning. In the previous study, the TiO 2 multi-channel electrospinning fibers has been successfully fabricated. [1] But the mechanical properties of inorganic multi-channel fibers were poor, which limit the practical application. [2] Figure 1. The SEM images of the cross section of double channel fibers. (a - c) The PLGA fibers, and the flow rate of the external fluid is 8 ml/h. The flow rate ratios of the outer to inner fluids are (a) 10:1, (b) 15:1, (c) 20:1. (d) The PCL double channel fibers. Herein, PLGA and PCL were used as external fluids, paraffin oil as the internal fluid for electrospinning. This fiber membrane has good flexibility and stability. In the experiment, by regulating the voltage and the flow rate ratio of the inner and outside fluid, we can adjust the diameter of the fiber and the internal channel. Depending on the need, a variety of functional applications could be achieved by changing the type of external fluid polymer. This kind of flexible multi-channel would have a good application prospects.in the drug release, thermal insulation, liquid transport. Key words: double channel, electrospinning, flexible, nanofibers Reference: [1] Zhao, Y., Cao, X. & Jiang, L. Bio-mimic multichannel microtubes by a facile method. Journal of the American Chemical Society 129, (2007). [2] Zhao, T. et al. Multichannel TiO 2 hollow fibers with enhanced photocatalytic activity. Journal of Materials Chemistry 20, 5095, doi: /c0jm00484g (2010).

222 Preparation of Multi-structured SiO Electrospun Nanofibrous Membranes for Copper Ions Removal from Polluted Water Haohong Pi, Xiuqin Zhang *, Jing Wu * Beijing Key Laboratory of Clothing Materials R&D and Assessment, Beijing Engineering Research Center of Textile Nanofiber, School of Materials Science and Engineering, Beijing Institute of Fashion Technology, Beijing , China. (Haohong Pi); (Xiuqin Zhang); (Jing Wu). The low-cost, heavy metal ion (Cu(II)) adsorptive multi-structured nanofibrous membranes of silicon oxide naonoparticles in-situ anchored polyvinylidene fluoride-hexafluoropropylene (SiO fibers were fabricated by the facile electrospinning technique combined with sol gel strategy. Taking advantage of the constructed multi-structures and efficient fiber morphology regulation which not only changed the PVDF-HFP nanofibrous membrane from hydrophobic to superhydrophilic but also increased the porosity of the membrane, the SiO nanofibrous membrane with a smaller diameter and a larger porosity exhibits higher Cu(II) adsorption capacity. The adsorption amount was approximate to 21.9 mg per gram of the membrane, which was higher than that of membranes with larger fiber diameter (smaller porosity) and the smooth one. Furthermore, the Freundlich model and the pseudo-first-order were well fitted to the adsorption experimental data. It not only uncovers the structure-related-property of multi-structured nanofibrous membranes, but also provides an efficient and facile way to design heavy metal ion adsorption materials. Key Words: electrospun, multi-structured, nanofibrous membrane, copper ion (Cu(II)) adsorption Acknowledgements: This research was funded by National Natural Science Foundation of China (NSFC) ( ), The Beijing Great Wall Scholars Incubator Program (No. CTT&TCD ), Beijing Natural Science Foundation ( ), Youth Outreach Project of Beijing Institute of Fashion Technology (BIFTBJ201806). : [1] Jing, W, Nü, W, Yong, Z, et al. Electrospinning of multilevel structured functional micro- /nanofibers and their applications [J]. Journal of Materials Chemistry A, 2013, 1(25): [2] Jing, W, Nü, W, Yong, Z, et al. Simple synthesis of smart magnetically driven fibrous films for remote controllable oil removal [J]. Nanoscale, 2015, 7(6): [3] Fang-fang, M, Nan, Z, Xiao, W, et al. Blend-electrospun poly(vinylidene fluoride)/polydopamine membranes: Self-polymerization of dopamine and the excellent adsorption/separation abilities [J]. Journal of Materials Chemistry A, 2017, 5,

223 High-Density, Mechanically Stable Polymer Fiber-Based Sponges with High Hydrophilicity Chengzhang Xu 1, Seema Agarwal 1, and Andreas Greiner 1 Macromolecular Chemistry and Bavarian Polymer Institute, University of Bayreuth, Universität sstrasse 30, Bayreuth, Germany. 3D porous biodegradable polymer fiber-based sponges with hierarchical pore structure were prepared by cutting electrospun nonwoven of polylactide/poly(ε-caprolactone) (PLA/PCL) blend into short fibers, and subsequent freeze-drying and thermal annealing [1]. Surface modification is applied on the sponges in order to obtain hydrophilic substrate which is favorable for further surface coating [2]. The sponges feature high stiffness with mechanical stability in dry as well as wet state. Contact angle measurement and hydrophilic dye staining method reveal that the hydrophilicity of the PLA/PCL sponge is significantly higher as compared to the unmodified PLA/PCL sponge. Remarkably, a hydrophilic dye is homogenously distributed allover hydrophilic sponges whereas the hydrophobic sponges is only coated on the surface (Fig. 1). Figure 1. Cross section of PLA/PCL sponges with (left) and without (right) surface modification after immersing in hydrophilic dye for 30 min. Key Word: polymer fiber-based sponge, stiffness, surface modification, hydrophilicity [1] M. Mader, V. Jérôme, R. Freitag, S. Agarwal, A. Greiner, Biomacromolecules, 19, 1663 (2018). [2] C. Xu, J. Cheong, I.-D. Kim, X. Mo, S. Agarwal, A. Greiner, to be submitted.

224 Preparation and Characterization of Polyimide Ultrafine Fabrics from Photosensitive Polyimide Resins via Ultraviolet-Light Assisted Electrospinning Procedure Lin Qi, Chenyu Guo, Mengge Huangfu, Jingang Liu * Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing , China. Polyimides (PI) ultrafine non-woven fibrous mats have been well-known for their excellent thermal, electrical, and mechanical properties [1]. The mechanical properties of conventional PI nanofibers fabricated from the poly (amic acid) (PAA) precursors often deteriorated by the fusion of nanofilaments or pinholes during the high temperature baking procedure (>350 o C). PI non-woven mats electrospun from soluble PIs (SPIs) can eliminates the drawback of the PAA procedure. However, the PI ultrafine mats electrospun via SPIs are usually suffered from the poor solvent resistance and poor mechanical properties. In order to overcome the disadvantages above, a novel electrospinning procedure, that is ultraviolet-light assisted electrospinning (UVAES) method utilizing photocrosslinkable photosensitive polyimide (PSPI) [2] solutions as the spinning agents was proposed in the current work. In UVAES procedure, the pre-imidized PSPI solution, such as the one derived from 3,3',4,4'-benzophenonetetracarboxylic dianhydride (BTDA) and 1,1-bis(4-amino-3,5-dimethylphenyl)- 1-(3'-trifluoromethylphenyl)methane (TFMDA) was first processed via the conventional electrospinning procedure. Then, the PSPI ultrafine fibers with high specific surface areas and small diameters were irradiated by the high pressure mercury lamp (i-line, 365 nm). During the UV irradiation, crosslinking reaction occurred in the molecular chains in PSPI fibers. As can be seen from Fig. 1 that the PSPI ultrafine non-woven mat exhibited good thermal stability with the 5% weight loss temperatures (T 5% ) higher than 500 o C and glass transition temperatures (T g ) higher than 300 o C. The solubility test resulted indicated that the solvent resistance of the mats was highly enhanced by the UVAES procedure. The derived PI mat could maintain the pristine shape in polar aprotic N,Ndimethylacetamide (DMAc) solvent, while the PI mats without UV treatment was easily soluble in the same solvent. Thus, the UVAES procedure tremendously improved the solvent resistance of the PI mats electrospun from SPIs while maintaining the intrinsic thermo stability. Fig. 1. Thermal properties of electrospun PSPI non-woven mats. (a) TGA and DTG curves; (b) DSC curve; (c) solvent resistance test in DMAc. Key Words: photosensitive polyimide, electrospinning, solubility, thermal stability Acknowledgements: Financial support from the Fundamental Research Funds of China University of Geosciences, Beijing (No ) is gratefully acknowledged. [1] Ding Y, Hou H, Zhao Y, et al. Electrospun polyimide nanofibers and their applications [J]. Progress in Polymer Science, 2016, 61: [2] Fu M C, Higashihara T, Ueda M. Recent progress in thermally stable and photosensitive polymers [J]. Polymer Journal, 2018, 50(1):

225 The development of high porosity of polyacrylonitrile (PAN)/polystyrene (PS) /ZIF-67 composite nanofiber lithium ion battery separator Rong Qiang 1, Linya Qi 1, Jianxin He 1,2, Pingping Yuan, Wen Yu, Yuankun Chen 1 Henan Provincial Key Laboratory of Functional Textile Materials, Zhongyuan University of Technology, Zhengzhou , China. 2 Collaborative Innovation Center of Textile and Garment Industry, Henan Province, Zhengzhou , China. Abstract:In this paper, electrostatic spinning technology was employed to prepared polyacrylonitrile (PAN)/polystyrene (PS) /ZIF-67 composite nanofiber porous separator for lithium ion battery. The excellent heat resistance and high melting point of PAN can enhance the thermal stability of composite separator. In order to improve the porosity of the composite separator, PS was removed by heating PAN/PS at 380 C for 8 hours in N2 atmosphere. ZIF-67 is a new kind of porous material with ordered multichannel structure and rich pore structure, which is self-assembled by metal ions and organic ligands. Then on the base of these, ZIF-67 can further increase the porosity of the composite separator. Meanwhile ZIF-67 can make the pore distribution and pore diameter uniform, and improve the electrolyte wettability of the composite separator. The results show that the PAN/PS/ZIF-67 composite separator exhibit high porosity, excellent electrolyte wettability and high-temperature stability, and can significantly improve the electrochemical performance and cycle performance of lithium ion batteries. Figure 1. SEM images of the PAN/PS/ZIF-67 composite nanofibers. Keywords: Lithium ion battery separator, ZIF-67, polyacrylonitrile, polystyrene, electrochemical performance [1] Zhen Li, Jintao Zhang, Yan Lu, Xiong Wen (David) Lou*. A Pyrolyzed Polyacrylonitrile/Selenium Disulfide Composite Cathode with Remarkable Lithium and Sodium Storage Performances [J]. Science Advances, 2018, 4(6): 1-10.

226 Fabrication of Antibacterial Nanofibers Containing Cinnamon Oil Using Microstructure of Activated Carbon. Byeong Cheol Son 1, Chan Hee Park 1,2,*, Cheol Sang Kim 1,2,* 1 Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju, Republic of Korea 2 Division of Mechanical Design Engineering, Chonbuk national University, Jeonju, Republic of Korea ( Components extracted from natural materials with antibacterial properties are widely used as antibacterial agents. This natural oil is currently approved by the Food and Drug Administration (FDA) and is being used as a natural additive in medicines and cosmetics. In this study, the addition of activated carbon and cinnamon oil to PU nanofiber produces nanofiber with antibacterial properties. In order to prevent the volatility of the natural material oil, cinnamon oil is added to activated carbon having a large amount of microporous structure, Thereby producing nanofibers. In addition, in order to increase antimicrobial activity in the production of nanofibers using natural material oil, a large amount of oil should be added, but if a large amount of oil is added, the production of fibers is uneven. To compensate for this, various sizes of pores of activated carbon were absorbed in oil and then added to the solution to proceed with fiber production. In order to evaluate the antimicrobial activity, a disk diffusion test was performed with E. coli and Staphylococcus aureus. As a result, it was confirmed that the antibacterial property of the fiber added with the same amount of the activated carbon as the nanofiber added with cinnamon oil was high. Therefore, if electrospinning is carried out in the application of activated carbon, it is expected that it will be possible to increase antimicrobial activity with a small amount of natural oil, and to produce drug release and additional antibacterial fiber. Key Words: (Antibacterial, Activated carbon, Cinnamon oil, electrospinning, nanofiber) : [1] Jin Kim, Chang Moon Lee, Antibacterial effects of Glycol Chitosan-Eicosapentaenoic Acid Nanoparticles containing Cinnamon Oil. [J]. Chitin chitosan, 2015, 20(1), [2] Min-Soo Kim, Kyoung-Won Lee, Eun-Jin Park, Antimicrobial Activity of Lavander and Rosemary Essential Oil Nanoemulsions. [J] Food Cook Sci

227 Effects of electrode polarity and voltage on the microstructure of electrospun polymer/inorganic composite fibers prepared by different polymers Juan Wang, Shuwei Yao, Qiang Liu, Yunzhu Ma, Wensheng Liu National Key Laboratory of Science and Technology for National Defence on High-strength Structural Materials, Central South University, Changsha , PR China. Polymer/inorganic composite nanofibers are widely used in polymer toughening agents, magnetic recording and storage, wave absorbing materials, stealth materials, biomedical materials and so on [1]. Electrospinning is an important method for the preparation of such one-dimensional nanomaterials. The solutions for electrospinning were often mixtures of polymers and inorganics. Since the inorganic ions moved under high voltage [2], the effects of electrospinning voltage on the morphologies of these composite fibers were obviously different from that of polymer fibers. In this study, two kinds of electrospun polymer/3al 2 O 3 2SiO 2 composite fibers were successfully prepared using water-soluble polymer (polyvinylpyrrolidone, PVP) and non-water-soluble polymer (polymer polyvinyl butyral, PVB). Influence of the electrode polarity on fiber microstructures was mainly discussed for the preparation of high-performance composite nanofibers. The results showed that the effects of electrode polarity and voltage on these fibers were different. When the positive or negative voltage increased, the diameters of PVB/3Al 2 O 3 2SiO 2 fibers both increased and the morphologies of fibers prepared by negative polar deteriorated rapidly; However, the diameters of PVP/3Al 2 O 3 2SiO 2 fibers were basically unchanged, and the morphologies of negative polar fibers were more uniform. TEM and FT-IR results proved that PVP had crosslinked with alumina-silica precursor sol particles. It was concluded that the high uniform morphology of PVP/3Al 2 O 3 2SiO 2 fibers under different voltage conditions benefited from the crosslinks. In conclude, polymers, crosslinking with the inorganics, can effectively improve the stability of composite fiber morphology, as well as the uniformity of fiber microstructure. Fig.1 Schematic diagram of the microstructure of spinning jet at different electrodes: (a) PVP/3Al 2 O 3 2SiO 2 fibers; (b) PVP/3Al 2 O 3 2SiO 2 fibers Key Words: Polymer/inorganic composite nanofibers, electrode polarity, polymer, microstructure Acknowledgments: The authors gratefully acknowledge the financial support from the Chang Jiang Scholars Program of the Ministry of Education of China (Grant no. T ). [1] LU X, WANG C, WEI Y. One-dimensional composite nanomaterials: Synthesis by electrospinning and their applications [J]. Small, 2009, 5: [2] Urbanek O, Sajkiewicz P, Pierini F. The effect of polarity in the electrospinning process on PCL/chitosan nanofibers structure, properties and efficiency of surface modification[j]. Polymer, 2017, 124:

228 Preparation of Doped LiCl/PU Ultrafine Nanofibers and Its Application in Anti-Fog Screens Wanli Yue 1, Weili Shao 1, Yuankun Chen 1, Fan Liu 1,Libing Ren 2, and Jianxin He 1 1 Zhongyuan University of Technology Textile Institute, Zhengzhou,Postal Code ,The China. E- 2 Tianjin University of Technology, School of Textile Science and Engineering Tianjin, , The China) Abstract: Electrospun nanofibers are widely used in air filtration, oil-water separation, waterproof and moisture permeability due to their large specific surface area, high porosity and large aspect ratio. Importantly, air filtration is the most direct, most effective, and most promising field for nanofibers. In this work, ultrathin polyurethane nanofibers doped with lithium chloride were prepared by electrospinning technology and characterized by different techniques. The results show that when the PU concentration is 15wt% (the solid content of the salt is 0.3wt%), the morphology of the nanofibers is regular, the fiber distribution is uniform, and the diameter of the nanofibers is reduced from 247 nm to 84 nm. And the elongation at break of the fibers and the breaking strength is 256% and MPa, respectively. When the solid content of lithium chloride reaches 0.5wt%, the mechanical properties of the nanofibers deteriorate, the elongation at break and the breaking strength is 132% and MPa, respectively. Ultrasonic composite of nanofibers with a weight of 4-5g/m2 and 30-mesh fiberglass window screens was tested with TSI8130A at a gas flow rate of 5.33 cm/s and an aerosol particle size of 0.3μm. The filtration efficiency and the filtration resistance is % and 19.4Pa, respectively. Besides, the nanofiber has a gas permeability and a light transmittance of 7856 mm/s and about 80%, respectively. It can be seen that our prepared PU/LiCl ultrafine nanofibers have great potential application prospects in the field of air filtration. Figure 1.Preparation of Ultrafine PU nanofibers of Electrospun and performance studies Key words: Ultrafine nanofiber, Electrospinning, Air filtration, Lithium chloride [1] Sundarrajan S, Tan K L, Lim S H, et al. Electrospun Nanofibers for Air Filtration Applications [J]. Procedia Engineering, 2014, 75: [2] Zhu M, Han J, Wang F, et al. Electrospun Nanofibers Membranes for Effective Air Filtration[J]. Macromolecular Materials & Engineering, 2016, 302:

229 Durably Antibacterial Nanofiber Yarns Preparation from Graphene Oxide/Silver Nanoparticle Antibacterial Composite Wen Yu 1, Fangfang Wang 1*, Jianxin He 1,2*,LinYa Qi 1,PingPing Yuan 1,YuanKun Chen 1 1 Zhongyuan University of Technology Textile Institute, Zhengzhou,Postal Code , China. 2 Collaborative Innovation Center of Textile and Garment Industry, Henan Province,Zhengzhou , China.) Abstract: Since bacterial infections seriously threaten human s health, considerable attention is devoted to producing antibacterial fabrics. The design of antibacterial materials is a key point of producing antibacterial fabrics. Graphene in materials research has been attracting tremendous attentions, various silver nanoparticles (AgNPs)-decorated graphene oxide (GO) nanocomposites (GO- Ag) have received increasing attention owing to their antimicrobial activity. However, the establishment of GO-Ag metastable system is the key question. In this work, we synthesize a polyethyleneimine (PEI)-modified and AgNPs-decorated GO nanocomposite (GO PEI Ag) that has high stability in different solutions and showing substantially higher antimicrobial efficacy. The modification strategy characterized by FTIR spectra, UV-VIS spectrophotometers, X-ray diffraction, transmission electron microscopy and atomic force microscopy, et al. The preparation of antibacterial nanofiber yarns from PAN using conjugate electrostatic spinning mechanism, while spraying and spinning at a time. The experiments show that GO-PEI-Ag can stabilize adhesion in fiber surface. Besides, GO-PEI-Ag imparts the fabric dual functions with deodorization and antibacterial properties. The antibacterial nanofiber yarns against Staphylococcus aureus and Escherichia coli are still more than 90% active after 50 times of mechanical washing. Especially, it was found that biocompatible antibacterial materials greatly enhanced the antibacterial activity and bacterial antiadhesion of the treated fabrics. Figure 1 Preparation of antibacterial fabrics. Key Words: Graphene oxide, Electrostatic spinning, Nanofibers, Antibacterial activity, Silver nanoparticles [1] Lin J, Chen X Y, Chen C Y, et al. Durably antibacterial and bacterially antiadhesive cotton fabrics coated by cationic fluorinated polymers[j]. ACS applied materials & interfaces, 2018, 10(7): [2] Zhao R, Kong W, Sun M, et al. Highly stable graphene-based nanocomposite (GO PEI Ag) with broad-spectrum, long-term antimicrobial activity and antibiofilm effects[j]. ACS applied materials & interfaces, 2018, 10(21):

230 Preparation and Properties of Fluorinated Polyurethane/Polyurethane High Hydrophobic Nanofiber Membrane Yuankun Chen 1, Wen Yu 1,Chunhui Liu 1, Wanli Yue 1, Fan Liu 1,2,Weili Shao 1,2,Jianxin He 1,2 1 Zhongyuan University of Technology Textile Institute, Zhengzhou,Postal Code ,The China. E- mail: 2 Collaborative Innovation Center of Textile and Garment Industry, Henan Province, Zhengzhou , China.) Abstract: In order to construct a high-efficiency and low-resistance waterproof filter material, the nanofiber membrane was prepared by adding fluorine-containing polyurethane to polyurethane spinning solution and using electrospinning technology. The morphology and properties of fiber structure were systematically characterized. The results show that when the PU concentration is increased from 10% to 18%, the spinnability is gradually improved, and the droplets in the fiber membrane are reduced. When the concentration exceeds 15%, the fiber diameter becomes coarser and the fiber diameter distribution becomes larger. As the FPU/PU ratio increased from 6% to 18%, the contact angle increased from 118 to 142, and the hydrophobicity of the fiber membrane was significantly enhanced. When the air flow rate is 5.33 cm/s and the NaCl aerosol particle size is 0.3 μm, the filtration efficiency reaches %, and the filtration resistance reaches 28.5 Pa. It can be seen that the prepared nanofiber membrane has improved hydrophobic properties, and has excellent filtration performance after compounding, and has great application prospects in the field of air purification. Figure 1. Preparation of Electrospun FPU/PU Nanofiber Membrane Key words: Nanofiber membrane, Fluoropolyurethane, Hydrophobicity, High efficiency and Low resistance [1] Wu W, Yuan G, He A, et al. Surface Depletion of the Fluorine Content of Electrospun Fibers of Fluorinated Polyurethane[J]. LANGMUIR, 2009, 25(5): [2] Jing Z, Xianfeng W, Lifang L, et al. Human Skin-Like, Robust Waterproof, and Highly Breathable, Fibrous Membranes with Short Perfluorobutyl Chain for, Eco-Friendly Protective Textiles[J]. ACS Applied Materials & Interfaces, 2018:acsami.8b

231 CO 2 -expanded three-dimensional nanofiber scaffolds for bone repair Yingnan Zhang 1,2, Kun Li 1,2, Junwei Xu 1,2, Ping Li 1,2* 1 School of Biological Science and Medical Engineering, Beihang University, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing, , China. 2 Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, , China. Electrospinning has been widely used in tissue engineering due to its ability to fabricate nanofibrous scaffolds that can simulate the extracellular matrix [1].Since these two-dimensional mats are composed of densely packed fiber layers with only superficial pores, they are not suitable for cell infiltration and the transfer of nutrients [2]. Therefore, increasing the porosity while retaining the fiber structure has also attracted the attention of researchers. In this study, the Polycaprolactone (PCL)- Icariin (ICA) nanofiber mat was prepared by electrospinning, and then expanded into a threedimensional scaffold with high porosity without changing the morphology of nanofiber by CO 2 gas foaming. As shown in Fig.1, the expanded three-dimensional scaffold forms a layered structure with loosely packed nanofibers. The scaffolds were co-cultured with MC3T3-E1 pre-osteoblasts for testing cell compatibility and the ability of cell infiltration. The results showed that the three-dimensional scaffolds had better cell viability and cell infiltration than the two-dimensional scaffolds, while ICA promoted proliferation, differentiation and mineralization of osteoblasts. The three-dimensional scaffold with ICA prepared by the CO 2 gas foaming method has a good prospect in bone repair. Fig.1 SEM images showing SEM images showing crosssectional morphologies of 3D scaffold Key Words: Three-dimensional scaffold, Tissue engineering, Bone repair, Gas forming Acknowledgements: This work was supported by funds from National Natural Science Foundation of China (NSFC) Research Grant ( , , , and ), and also supported by 111 Project (B13003). [1] Jiang J, Chen S, Wang H, et al. CO 2 -expanded nanofiber scaffolds maintain activity of encapsulated bioactive materials and promote cellular infiltration and positive host response[j]. Acta Biomater, 2018, 68: [2] Wu J, Hong Y. Enhancing cell infiltration of electrospun fibrous scaffolds in tissue regeneration[j]. Bioact Mater, 2016, 1(1):

232 Synthesis and characterization of carbon nanofibers core-shell catalyst for hydrolysis of carbonyl sulfur and carbon disulfide Yishan Zhang 1, Xin Sun 1, Chi Wang 2, Ping Ning 1, Kai Li 1,*, Xin Song 1,* 1 Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, , China 2 Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming, , China * Corresponding author: Kai Li, Tel: ; Fax: ; Xin Song, ABSTRACT In this work, a series of carbon nanofibers core-shell catalysts were prepared via electrespinning method, and used for hydrolysis of carbonyl sulfur and carbon disulfide. The influences of preparation conditions for catalytic activity were investigated. Under optimum preparation conditions, the removal rate of COS and CS 2 was 100%, and the sulfur capacity was mgs/g. BET results showed that most of micropore diameters were concentrated at 1.2 nm, and the surface area of catalyst was 1546 m 2 /g. XPS results showed that the main active components were Fe 2 O 3 and CeO 2. FTIR results showed that OH groups and C=O groups were conducive to the chemical adsorption and catalytic hydrolysis for COS and CS 2. SEM results showed that Fe 2 O 3 and CeO 2 were evenly dispersed on the surface of carbon nanofibers, which enhanced the catalytic activity. Therefore, nanofibers is a kind of effective catalysts for COS and CS 2. Key Words: Carbon nanofibers, Core-shell catalyst, Electrospinning, Carbonyl sulfur, Carbon disulfide

233 Low temperature fabrication of the welded metal oxide nanofibers and their application in electronic devices Chuanyu Fu 1,2,3, Youchao Cui 1,2,3, You Meng 1,2,3, Zhao Yao 1,2,3, Yanan Ding 1,2,3, Guoxia Liu 1,2,3, and Fukai Shan 1,2,3 1 College of Physics, Qingdao University, Qingdao , China. 2 College of Microtechnology & Nanotechnology, Qingdao University, Qingdao , China. 3 Collaborative Innovation Center for Eco-Textiles of Shandong Province, Qingdao , China. Abstract: Electrospinning technique is considered as the most powerful approach for preparing one-dimensional (1D) metal oxide nanofiber networks (NFNs) and fabricating the NFNs-based electronic devices. 1 However, there are also inherent shortcomings, including (i) high contact resistance at the junctions of nanofibers, (ii) poor adhesion between nanofibers and substrate and (iii) excessive annealing temperature. In this report, the NFNs based on welded amorphous In 2 O 3 nanofibers were fabricated at low temperature by electrospinning using polymethyl methacrylate (PMMA) as polymer for the first time. Benefiting from the good thermoplasticity and low decomposition temperature of PMMA, the aforementioned obstacles have been solved well. The characteristics of In 2 O 3 nanofibers, together with the electrical performance of In 2 O 3 based field effect transistors (FETs) were systematically investigated as a function of nanofiber densities and annealing temperature. It was found that the FETs based on In 2 O 3 nanofibers, with annealing temperature of 320 o C and nanofiber density of 0.4 μm -1, exhibited the best device performance, including a field-effect mobility (μ FE ) of 1.27 cm 2 /Vs, a current ratio of , a threshold voltage (V TH ) of 9 V. When solution-processed AlO x was integrated into the FETs as dielectric layers, the device performance has been further improve, including a μ FE of 5.01 cm 2 /Vs, a V TH of 0.7 V and a SS of 180 mv/decade, respectively. This proposed neoteric method provide a new scheme to weld metal oxide nanofibers and hence improve the electronic performance of devices based on welded nanofibers. Fig. 1 Transfer characteristics of In 2 O 3 nanofibers/sio 2 FETs with various annealing conditions and nanofiber densities (V DS = 30 V). Key Words: PMMA, welding process, nanofibers, field effect transistors, low temperature Acknowledgements: This work was supported by the National Natural Science Foundation of China (Grant No , , and ) [1] X. Duan, C. Niu, V. Sahi, J. Chen, J. W. Parce, S. Empedocles, and J. L. Goldman, High- Performance Thin-Film Transistors Using Semiconductor Nanowires and Nanoribbons. Nature, 2003, 425(6955):

234 Magnetic carbon nanofibers deriving from electrospun cellulose/fe 3 O 4 fibrous nanocomposites Georgia Papaparaskeva, Panayiotis S. Ioannou, Ioannis Giapintzakis,Theodora Krasia- Christoforou Department of Mechanical and Manufacturing Engineering University of Cyprus, P.O.Box 20537, 1678, Nicosia, CYPRUS Carbon nanofibers (CNFs), are promising additives for composite materials dedicated for high-end applications. High surface area, electrical/thermal conductivity, and mechanical properties of CNFs enable the realization of reinforced composites, sensors, energy conversion and storage devices. Electrospinning and post thermochemical treatment, enables a controlled, repeatable and cost effective fabrication and functionalisation approach for CNFs. Surface activation with photocatalytic, piezoelectric or magnetic moieties enhances electronic, thermal mass and stress transport properties of a composite, enriching CNFs applicability. Herein we present a 3-step fabrication route for the generation of CNFs decorated with magnetic Fe 3 O 4 nanoparticles (NPs). The presented methodology employs Fe 3 O 4 activated electrospun cellulose nanofibers as Fe 3 O 4 /CNF precursors. Fabrication process includes: (i) Electrospining of cellulose acetate fibers (CAFs), (ii) transformation of CAFs into cellulose fibers via base hydrolysis, (iii) in situ generation and anchoring of Fe 3 O 4 NPs onto the cellulose fiber surfaces. The magnetic fibrous polymer nanocomposites were subsequently transformed into magnetic Fe 3 O 4 /CNF by carbonization. The final product and its precursors were characterized by SEM, TEM/EDX, XRD and FTIR. These materials could be exploited as electrodes in supercapacitor technologies, adsorbents in water remediation processes and as high surface area photocatalytic substrates. Acknowledgment: The presented results is the outcome of a co-funded project from Research Promotion Foundation of the Republic of Cyprus, European Regional Development Fund and Structural Funds of the European Union in Cyprus; Acronym: GELY, ENTERPRISES/0916/065. We are grateful to Dr. Drd.ing. Eugenia Tanasă (Politehnica University of Bucharest) for the TEM/EDX analysis.

235 3.6 Nanofiber for catalyst

236 Co nanoparticles embedded in 1D Carbon nanofibers as efficient hydrogen evolution reaction electrocatalysts. Hongge Ding 1, NüWang 1, Zhimin Cui 1, Yong Zhao* 1 1 Beihang Univ, Key Lab Bioinspired Smart Interfacial Sci & Techn, Beijing Key Lab Bioinspired Energy Mat & Devices, Minist Educ,Sch Chem,Beijing Adv Innovat Ctr Biom, Beijing , Peoples R China. Water electrolysis is considered as the most promising technology for hydrogen generation. [1] Electrolysis of water to produce hydrogen efficiently considered as a doable access. Optimum electrocatalysts can drive down the energy costs needed for water splitting via lowering the over potential. Lots of researches focus on non-noble materials to anticipate costs decreases, transition metal based electro-catalysts draw most attention on account of its abundant supplies and pretty good intrinsic ability on HER. [2] Electrospinning as a versatile top-down technique for preparing 1 D structure materials including solid and hollow ultrathin fibers by electrostatic forces. With unique characteristics such as high surface-to-volume ratios and the ability to producing highly porous fibrous networks excellent pore interconnectivity. As well as controllable fiber diameters which exhibited high surface area, excellent electron transport, facile electronic transport, and superior stability. [3] Some of Co (Cobalt) based electro-catalysts were applied on water electrolysis, there in Co doped carbon material display a common role. Fig.1 SEM and TEM of prepared solid and hollow structure Co doped CNFs. Solid Co doped CNFs a) TEM b) DES mapping; C) XRD of solid and hollow CNFs. Hollow Co doped CNFs d) TEM; e) DES mapping; f) Raman spectra of different carbonization temperature. Key Words: HER, carbon material, Co doped carbon material. [1] CHEN Z, WU R, LIU Y, et al. Ultrafine Co Nanoparticles Encapsulated in Carbon-Nanotubes- Grafted Graphene Sheets as Advanced Electrocatalysts for the Hydrogen Evolution Reaction [J]. Adv Mater, 2018, e [2] RAO C N R, CHHETRI M. Borocarbonitrides as Metal-Free Catalysts for the Hydrogen Evolution Reaction [J]. Adv Mater, 2018, e [3] ZHANG C L, YU S H. Nanoparticles meet electrospinning: recent advances and future prospects [J]. Chem Soc Rev, 2014, 43(13):

237 Controlled synthesis of titanium dioxide/molybdenum disulfide core-shell hybrid nanofibers with enhanced peroxidase-like activity for colorimetric detection of glutathione Wendong Zhu, Maoqiang Chi, Mu Gao, Ce Wang, Xiaofeng Lu* Alan G. MacDiarmid Institute, College of Chemistry, Jilin University, Changchun, , P. R. China. Tel: Synergistic effects play a crucial role in improving the catalytic activity of enzyme-like reactions. The preparation of hybrid nanomaterials for enzyme mimicking that display synergistic enhanced catalytic activity remains a formidable challenge. Titanium dioxide (TiO 2 ) has attracted enormous interest and has been extensively studied due to its advantages of unique photoelectrical properties, high stability, low cost, and nontoxicity. [1] MoS 2 nanosheets have been found to show intrinsic peroxidase-like activity that could be exploited in the sensitive detection of H 2 O 2, glucose, and ascorbic acid. [2] However, the peroxidase-like activity of individual MoS 2 is not sufficiently high for practical applications. Herein, titanium dioxide (TiO 2 )/molybdenum disulfide (MoS 2 ) core-shell hybrid nanofibers were synthesized as efficient peroxidase mimics via a three-step approach involving electrospinning, calcination, and hydrothermal treatment. [3] The resulting TiO 2 /MoS 2 hybrid nanofibers exhibited synergistically enhanced peroxidase-like catalytic activity relative to the TiO 2 nanofibers or MoS 2 nanosheets alone. Based on the high peroxidase-like activity of the TiO 2 /MoS 2 hybrid nanofibers, a simple colorimetric approach for the detection of L-glutathione (GSH) was developed, with a detection limit as low as 0.1 M. This study provides a simple and sensitive sensing platform for the detection of GSH, with prospective applications in colorimetric sensing, environmental monitoring, and medical diagnosis. Schematic illustration for the peroxidase-like activity of TiO 2 /MoS 2 core-shell nanofibers and their sensitive detection of glutathione Key Words: titanium dioxide; molybdenum disulfide; peroxidase-like activity; colorimetric detection Acknowledgements: This work was financially supported by the National Natural Science Foundation of China ( , and ). [1] Lee K, Mazare A, Schmuki P, et al. One-dimensional titanium dioxide nanomaterials: nanotubes [J]. Chem. Rev., 2014, 114: [2] Hu Y L, Huang Y, Tan C L, et al. Two-dimensional transition metal dichalcogenide nanomaterials for biosensing applications [J]. Mater. Chem. Front., 2017, 1, [3] Zhu W D, Chi M Q, Gao M, et al. Controlled synthesis of titanium dioxide/molybdenum disulfide core-shell hybrid nanofibers with enhanced peroxidase-like activity for colorimetric detection of glutathione [J]. J. Colloid Interf. Sci., 2018, 528:

238 Preparation of PAN/BiOI micro/nano composite fiber with photocatalytic performance Xiaofei Guo, Mingyue Zhu, Si Cheng, Lixing Dai, Chuanxiang Qin* College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Soochow, P. R. China. In the face of increasing serious environmental pollution problems, such as sewage treatment, many methods had been used. For example, filtration, adsorption, and photo-degradation. Here, polyaniline was polymerized in situ on the surface of the PAN(polyacrylonitrile) microfiber to form conductive PAN microfiber. Secondly, it was coated by electrospun PAN nanofiber mats. Finally, PAN/BiOI micro/nano composite fiber was fabricated through chemical deposition & hydrothermal reaction. Fig.1(a) shows that the surface of conductive PAN microfiber was rough for the polyaniline coating, while Fig.1 (b) shows that BiOI sheets were arranged along the growth of PAN nanofiber, which increased the specific surface area. After visible light irradiation for 7.5 h (Fig.1(d)), 36.1% of RhB aqueous solution was degraded by the BiOI powder. However, the degradation rate of RhB aqueous solution by PAN/BiOI micro/nano composite fiber could reach up to 91.1%. Fig.1 The SEM images of conductive PAN microfiber (a) and PAN/BiOI micro/nano composite fiber (b). The XRD pattern of different samples (c).the absorbance (554 nm) of RhB aqueous solution when using BiOI powder and PAN/BiOI micro/nano composite fiber under visible-light irradiation (d). Conclusion: The new photocatalytic material PAN/BiOI micro/nano composite fiber prepared by electrospinning, chemical deposition & hydrothermal method, had a large specific surface area and good photocatalytic performance. In addition, after the photo-degradation experiment, the photocatalytic material can be recycled easily by simple filtration. Key Words: polyacrylonitrile, micro/nano fiber, photocatalyst, bismuth oxyiodide(bioi) Acknowledgements: The authors acknowledge the financial support of the Natural Science Foundation of Jiangsu Province (Grant No. BK ), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), China.

239 Abstract for the Electropin 2019 Durability characteristics of subzero start-up for electrospun nanofiber electrodes Han Liu 1 Dechun Si 2, Han Ding 2, Junning Wen 3, Yong Liu 4* 1, 5*, Jianbo Zhang 1 College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing Department of Automotive Engineering, State Key Laboratory of Automotive Safety and Energy, Tsinghua University, Beijing College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing School of Science and Technology, Tokai University, Hiratsuka, Japan, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing Beijing Co-Innovation Center for Electric Vehicles, Beijing Institute of Technology, Beijing Reducing costs and increasing cold start capability are key to improve the commercialization of proton exchange membrane fuel cells (PEMFC). At present, it has been reported that the nanofiber electrodes prepared by electrospinning technology can improve catalyst utilization, increase thriple-phase boundary (TPB) and thriple-phase channel (TPC), and improve durability [1]. However, few studies have focused on the subzero start-up of the electrospun electrodes. Therefore, this paper compare the subzero start-up capability between electrospun electrodes and electrosrayed electrodes with the same platinum loading at temperatures of -5 C and a current of 40 ma/cm 2 under isothermal conditions. The results show that the subpriming capability of the electrospun electrodes is stronger than that of the electrosprayed electrodes. Meanwhile, after undergoing multiple subzero start-up, the performance of the electrospun electrodes remains unchanged, while the performance of the electrosprayed is seriously degraded, which indicates that the durability of the electrospun electrodes is better than that of electrosprayed electrodes. Figure.1 The results of subzero start-up at -5 and 40mA cm -2. Figure.2 The performance degradation of electrospun nanofiber electrodes. Figure.3 The performance degradation of electrosprayed electrodes. Key words: fuel cell, subzero start-up, electrospun nanofiber electrodes, electrochemical impedance spectroscopy (EIS) : [1] D. Si, S. Zhang, J. Huang, C.Wang, Y. Liu, J. Zhang. Electrochemical Characterization of Pre-conditioning Process of Electrospun Nanofiber Electrodes in Polymer Electrolyte Fuel Cells[J]. Fuel Cells, 2018, No 5:

240 Abstract for the Electropin 2019 Effects of Increasing Chitosan Nanofibre Volume Fraction on the Mechanical Property of Hydroxyapatite BY ENEMUO MOSES,ENEMOR EDWIN,AND ANYABULU ELOCHUKWU UNIVERSITY OF ABUJA This work attempted to synthesize chitosan (CH) nanofibre from crab shell and hydroxyapatite, HA, from limestone with the objective of studying the effects of increasing volume fraction of chitosan nanofibre on the mechanical properties of HA. Mechanical characterization of different fraction composite was carried out to study the effects of increasing volume fraction of chitosan nano fibre on the mechanical properties of HA. In addition, surface characterization of the composite was carried out using Fourier Transform Infrared Spectrometry, FT-IR. Results obtained indicated that the optimum mechanical properties were obtained at a volume fractions of 30: 70, CH: HA respectively; average compressive strength of MPa; average tensile strength of MPa; average hardness value of HV; average fracture toughness of MPa.m 1/2 ; average elastic modulus of GPa and average bending strength of MPa were obtained for this optimum volume fractions. Increasing volume fractions of chitosan nanofibre was therefore found to result in decrease in compressive strength, hardness and elastic modulus of HA while its tensile strength, bending strength and fracture toughness increased. The FTIR revealed that possible interaction between the NH 2 group and the primary and secondary OH group of CH with Ca 2+ (metal coordination interaction) of HA might be responsible for the higher mechanical property of HA. In conclusion, it was found that increasing chitosan volume fraction in chitosan/ha composite results in increasing strength of hydroxyapatite, consequently enhancing its load bearing ability.

241 Abstract for the Electropin 2019 Electrospun Egg White Protein Nanofiber Membrane for Cell Catalysis Tingting Lv 1, Ying An 1, Haoyi Li 1, Yujian Liu 1, Xiaoqing Chen 1 1 College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, P.O.Box Absract: Electrospinning technology is a method of preparing nanofibers by stretching polymer to form jet under the traction of high voltage electrostatic field force (as shown in Fig. 1). The nanofibers obtained by electrospinning have the characteristics of high specific surface area, high porosity and high volume ratio [1]. In order to expand the application field of electrospinning nanofibers and broaden the source of materials for electrospinning, egg white was used as raw material for electrospinning [2]. In order to overcome the problem of protein denaturation caused by organic solvents in traditional electrospinning process, water-soluble polymers were used instead of organic solvents to protect the biological activity of egg white protein, improve the mechanical properties of protein fibers, and do not pollute the environment. The effects of solution ratio, spinning voltage, temperature and acceptance distance on the morphology of egg white fibers were investigated. The results of scanning electron microscopy (SEM) showed that the average diameter of egg white fibers membrane was 200 nm (as shown in Figure 2). The prepared protein fiber membrane was carbonized in muffle furnace at 400. The carbonized protein fiber membrane can be used in the field of cell catalysis. In this experiment, no organic solvents were used, and the egg albumin fibre membrane prepared by the experiment had excellent biodegradability and did not pollute the environment. Figure1. Schematic diagram of electrospinning device Figure2. SEM of Egg Albumin Fiber Key Words: Electrospinning; Protein; Egg white; Cell Catalysis [1] Jochen, Bürck, Stefan H, Udo G, et al. Resemblance of electrospun collagen nanofibers to their native structure[j]. Langmuir, 2013, 29(5): [2] Tiwari S K, Venkatraman S. Electrospinning pure protein solutions in core shell fibers[j]. Polymer International, 2012, 61(10):0-0.

242 Intensity (a.u.) Facile electrospinning preparation of carbon nanofibers as bifunctional electrocatalyst Sijia Jin 1, Yingying Zhang 1, Xinzhi Zang 1, Yan li 1, Yaxin Hu 1, Quanfa Zhou 2, Hengfei Qin 1, 1 Jiangsu key laboratory of E-waste Recycling, School of Chemistry and Environmental Engineering, Jiangsu University of Technology, No. 1801, Zhongwu Road, Changzhou City, , China. 2 School of Mathematical Science and Chemical Engineering, Changzhou Institute of Technology, No. 666, Liaohe Road, Changzhou City, , China With the increasing environmental problems and energy crisis, great attention was focused on sustainable energy sources, including designing novel and efficient energy-storage devices and developing earth-abundant energy resources. Hydrogen, one of the renewable clean energy with high mass-specific energy density, has been urgently needded as a promising energy carrier. Considering its cost and purity, electrolytic water is the most effective way to produce hydrogen at present, including oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) electrocatalytic electrode material is an important factor restricting the efficiency of hydrogen production. In this paper, a mixture of lignin and PAN was used as the carbon source, and the cobalt nitrate was used as metal source. First, the is obtained by pre-oxidation and high-temperature calcination by electrospinning, and then by hydrothermal method successfully prepared composite nanofiber material. In this system, first, due to the synergistic effect of Co, Ni and graphitized carbon, the conductivity and electron transport ability of the system were improved, and the electrocatalytic performance was increased. Furthermore, the structure of graphitized carbon encapsulated transition metals plays a limiting role, which limits the agglomeration and growth of metal nanoparticles in the reaction process, thus maintaining good stability. Thus exhibiting excellent HER electrocatalytic activity, such as exhibiting a low initial overpotential in a 0.5 M sulfuric acid solution (~ 50mV) and low Tafel slope (~45 mv/dec). After cycles of testing, the current density did not change, showing outstanding catalytic stability. (a) (b) Graphite carbon Ni Theat (Degree) Fig. 1(a) SEM and (b) XRD of carbon nanofibers Key Words: Oxygen electrode, Oxygen reduction reaction, Oxygen evolution reaction, Carbon nanofibers, Non-precious metal catalysts Acknowledgements: The work was supported by the National Natural Science Foundation of China (Grant No ), the Natural Science Foundation of Jiangsu Province (Grant No. BK ). [1] Liu T T, Asiri A M, Sun X P, et al. Electrodeposited Co-doped NiSe 2 nanoparticles film: a good electrocatalyst for efficient water splitting [J]. Nanoscale, 2016, 8:

243 Flexible MnO 2 nanofibrous membranes with enhanced catalytic performance Xueqin Wang College of Textile, Qingdao University, , Qingdao, China. Constructing nanostructured catalyst-embedded ceramic fibrous membranes would facilitate the remediation or preliminary treatment of dyeing wastewater, however, most of such membranes are brittle with low deformation resistance, thus, restricting their widely applications [1,2]. Herein, the flexible and hierarchical nanostructured MnO 2 -immobilized SiO 2 nanofibrous membranes (MnO 2 NFM) were fabricated by combining the electrospinning technique with hydrothermal method [3]. The morphologies of membranes could be regulated from nanowires and nanoflower to mace-like structure via varying con-centration of reactants. The resultant MnO 2 NFM could cooperate with hydrogen peroxide to form a Fenton-like reagent for the degradation of methylene blue (MB). The resultant membrane exhibited prominent catalytic performance towards MB, including high degradation degree of 95% within 40 min, fast degradation rate of min 1, and excellent reusability in 5 cycles. Moreover, the membranes could be used in a wide ph range of 0 to 14 and the degradation degree reached 76% during dynamic filtration process with a high flux. The successful fabricating of such membrane with extraordinary catalytic performance would provide a platform for preparing high-performance catalysts for remediation of dyeing wastewater. The SEM images of (a) pristine SiO 2 and (b-d) MnO 2 NFM. The optical images showing the flexibility of (e) SiO 2 and (f) MnO 2 NFM. (g) The tensile strength and bending rigidity of various MnO 2 NFM. Key Words: Electrospinning, Flexibility, MnO 2 -embeded-sio 2 nanofibrous membranes, Fenton-like catalyst [1] Sigmund W, Yuh J, Park H, et al. Processing and Structure Relationships in Electrospinning of Ceramic Fiber Systems [J]. Journal of the American Ceramic Society, 2006, 89(2): [2] Wang X, Doug L, Li Z, et al. Flexible hierarchical ZrO 2 nanoparticle-embedded SiO 2 nanofibrous membrane as a versatile tool for efficient removal of phosphate [J]. ACS Applied Materials & Interfaces, 2016, 8(50): [3] Wang X, Dou L, Yang L, et al. Hierarchical structured MnO 2 nanofibrous membranes with superb flexibility and enhanced catalytic performance [J]. Journal of Hazardous Materials, 2017, 324:

244 Cobalt Phosphides Grown on Electrospun Carbon Nanotubes as Hydrogen Evolution Reaction Catalyst in Acidic and Alkaline Medium Shuai Shen,Zhixiang Cui, Junhui Si College of Materials Science and Engineering, Fujian University of Technology, Fuzhou, China. Catalysts are indispensable in high-efficiency hydrogen evolution reactions, and the development of highly efficient hydrogen evolution reaction without precious metals remains a major challenge nowadays. In this work, We prepared cobalt phosphides which grown on carbon nanotubes as a highly active site. The carbon nanotubes were produced by electrospinning and high temperature heating, which promotes the electron transfer of the active material of the hydrogen evolution reaction. As the template, The carbon nanotube is coated with cobalt phosphide(co x P by depositing cobalt phosphide and then heating phosphating. The Co x P have a high specific surface area and large number of active sites. Due to the synergy of electron enhancement and nanostructures, the Co x P hybrid exhibits excellent HER performance,with a remarkable current density of 10 ma cm -2 at overpotential as low as 96 mv in 0.5 M H 2 SO 4 electrolyte and the current density of 10 ma cm -2 at overpotential 162 mv in 1.0 M KOH electrolyte. Therefore, this study provides favorable value for the further study of cobalt phosphide as a catalyst for hydrogen evolution. Keywords:Electrospinning,Carbon nanotube,cobalt phosphide,hydrogen evolution reaction : [1] Afriyanti Sumboja, Tao An, Hai Yang Goh, Mechthild Lübke al.one-step Facile Synthesis of Cobalt Phosphides for Hydrogen Evolution Reaction Catalyst in Acidic and Alkaline Medium [J]. ACS Appl. Mater Publication Date (Web): 19 Apr 2018 [2] Huahao Gu,Wei Fan,Tianxi Liu,et al.phosphorus-doped NiCo2S4 nanocrystals grown on electrospun carbon nanofibers as ultra-efficient electrocatalysts for the hydrogen evolution reaction[j].nanoscale Horiz., 2017,2 :

245 Ni Strongly Coupled with Mo 2 C Encapsulated in Nitrogen-Doped Carbon Nanaofibers as Robust Bifunctional Catalyst for Overall Water Splitting Meixuan Li 1, Yun Zhu 1, Huiyuan Wang 2, Ce Wang 1, Nicola Pinna 3, and Xiaofeng Lu 1 1 Alan G. MacDiarmid Institute, College of Chemistry, Jilin University, Changchun, , P. R. China. 2 Key Laboratory of Automobile Materials of Ministry of Education & School of Materials Science and Engimeering, Nanling Campus, Jilin University, No Renmin Street, Changchun , PR China. 3 Institute für Chemie and IRIS Adlershof, Humboldt-Universität zu Berlin, Brook-Taylor-Straße 2, Berlin, Germany. It is urgently required to develop highly efficient and stable bifunctional non-noble metal electrocatalysts for both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) for water splitting. [1] In this study, we have developed a facile electrospinning approach followed by a post-carbonization treatment to synthesize nitrogen-doped carbon nanofibers (NCNFs) integrated with Ni and Mo 2 C nanoparticles (Ni/Mo 2 C-NCNFs) as water splitting electrocatalysts. [2] Owing to the strong hydrogen binding energy on Mo 2 C and high electrical conductivity of Ni, synergetic effect between Ni and Mo 2 C nanoparticles significantly promote both HER and OER activities. The optimized hybrid (Ni/Mo 2 C(1:2)-NCNFs) delivers low overpotentials of 143 mv for HER and 288 mv for OER at a current density of 10 ma cm -2. An alkaline electrolyzer with Ni/Mo 2 C(1:2)-NCNFs as catalysts for both anode and cathode exhibits a current density of 10 ma cm -2 at a voltage of 1.64 V, which is only 0.07 V larger than the benchmark of Pt/C-RuO 2 electrodes. In addition, an outstanding long-term durability during 100 h testing without obvious degradation is achieved, which is superior to most of the noble-metal-free electrocatalysts reported to date. This work provides a simple and effective approach for the preparation of low-cost and high-performance bifunctional electrocatalysts for efficient overall water splitting. Schematic illustration for the fabrication process of Ni/Mo 2 C-NCNFs nanohybrids. Key Words: electrospinning, Mo 2 C, Ni, bifunctional electrocatalysts, overall water splitting Acknowledgements: This work was financially supported by the National Natural Science Foundation of China ( , , ). The project was also supported by Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. [1] Subbaraman R, Tripkovic D, Strmcnik K C, et al. Enhancing Hydrogen Evolution Activity in Water Splitting by Tailoring Li+-Ni(OH)(2)-Pt Interfaces [J]. Science, 2011, 334(6060): [2] Li M X, Wang H Y, Lu X F, et al. Ni Strongly Coupled with Mo2C Encapsulated in Nitrogen- Doped Carbon Nanofibers as Robust Bifunctional Catalyst for Overall Water Splitting [J]. Adv. Energy Mater., 2019,

246 Incorporation of rodlike rectorite into electrospun porous TiO 2 fibers for enhancing photocatalysis properties towards organic dye pollutions Dan Li 1, Hu Tu 1, 2, Chi Wang 1, Xiaowen Shi 1, Yumin Du 1 and Hongbing Deng 1 * 1 Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, Hubei Key Lab of Biomass Resource Chemistry and Environmental Biotechnology, School of Resource and Environmental Science, Wuhan University, Wuhan , China 2 College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, , China TiO 2 as photocatalytic material has been widely used in wastewater treatments due to its costeffective, high stability, and low toxicity [1, 2]. However, the photocatalytic activity of naked TiO 2 is not good enough to satisfy industrial requirements. For improving the photocatalytic efficiency of TiO 2, we not only raised the surface area of TiO 2 catalysts by electrospinning porous TiO 2 fibers but also modified TiO 2 with layered clay materials by incorporating rectorite (REC) into TiO 2 fibers. The porous electrospun polycaprolactone (PCL) fibers loaded TiO 2 and REC particles could facilitate high specific surface area, which contributed to highly efficient photocatalysis. The fibers with porous inner structure and surface were displayed from the images of field emission scanning electron microscope and transmission electron microscopy. Besides, the introduction of REC could reduce the diameters of fibers and enlarge the specific surface area, which might be beneficial to photocatalysis. Subsequently, the composite fibrous mats were calcinated in air to prepare inorganic TiO 2 /REC fibers for photocatalytic experiments. The results of photocatalytic properties for the as-fabricated TiO 2 fibers indicated that porous TiO 2 nanostructures could be a potential excellent photocatalyst in the degradation of dyes. It was also evident that REC played an important role in improving the function of TiO 2, which contributed to a high rate of photocatalytic degradation. Key Words: Polycaprolactone, TiO 2, Rectorite, Porous fibers, Electrospinning Acknowledgments: This work was supported by the National Natural Science Foundation of China(No ), partially supported by the Natural Science Foundation of Hubei Province of China (Team Project, No.2015CFA017) and the Fundamental Research Funds for the Central Universities of China (No kf0175). [1].Cui W Q, Jing H, Wang H, et al., Polyaniline hybridization promotes photo-electro-catalytic removal of organic contaminants over 3D network structure of rgh-pani/tio2 hydrogel [J]. Applied Catalysis B Environmental, 2018, 232: [2].Wang, W., M.O. Tadé, and Z. Shao, Nitrogen-doped simple and complex oxides for photocatalysis: A review [J]. Progress in Materials Science, :

247 Post-modification of Polymer Nanofibers by MOFs for Environmental Remediation and Gas Separation Jing Zeng, Fang Lu, Jinguang Wang, Jie Han and Zhenjun Chang College of Materials Science and Engineering, Jiangsu University of Science and Technology (JUST), , Zhenjiang, PR China. Electrospinning is the most versatile technology in use today for the generation of polymer, metal oxide, and even metal micro- and nanoscale fibers [1]. In past some years, surface modificated nanofibers have been of growing interest because of their potential applications in electronic devices, environmental remediation, filters, energy storage, and tissue engineering fields [2]. Among of polymer nanofibers, polyimide nanofibers also show several remarkable characteristics such as high thermal stability and high surface area to volume ratio. More importantly, the self-rich carboxyl groups from polyamic acid nanofibers as a precursor of PI nanofibers seem to be ideal for post modifacation We report a facile strategy for the synthesis of core shell polyimide/ CuBTC hybrid nanofibers by combining electrospinning, step-by-step seeding, and hydrothermal process [3]. The CuBTC nanocrystals can be well immobilized onto the surface of polyimide nanofibers. The hybrid nanofibers exhibited high gas separation and adsorption of methylene blue from aqueous solution. Furthermore, a new structure of hybrid nanofibers of ZIF-8-ZnO as shell and PI as core was prepared by combining electrospinning, hydrothermal process, and in situ growth nanoparticles. The hybrid nanofibers exhibited high photocatalytic properties, and excellent CO 2 /CH 4 and CO 2 /N 2 selectivities. Key Words: electrospinning, nanofibers, environmental remediation, MOFs, gas separation Acknowledgements: The authors gratefully acknowledge the support received from the National Natural Science Foundation and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). [1] Teo W E, Ramakrishna S. a review on electrospinning design and nanofibre assemblies [J].Nanotechnology, 2006, 17, R89-R106. [2] Ding B, Yu J Y. Electrospun Nanofibers for Energy and Environmental Applications [M], Springer Publishing, [3] Chang Z J, Zeng J. Immobilization seeding layers using precursor for fabricating core shell polyimide/cu BTC hierarchical nanofibers with high gas separation and adsorption of methylene blue from aqueous solution [J]. Macromolecular Chemistry and Physics, 2016, 217, Scheme 1. Illustration of the structure of CuBTC/PI and ZIF-8-ZnO/PI nanofibers.

248 Synthesis of Co 3 O 4 /g-c 3 N 4 /CNF S as binder-free and conductive-free electrode materials for supercapacitor Ruifang He 1, Xingwei Sun 2, and Jie Bai 1 Chemical Engineering College, Inner Mongolia University of Technology, Hohhot, Inner Mongolia, China, , Key words: graphite carbon nitride, carbon nanofibers, electrospinning, cobaltite oxide, supercapacitor. Graphitic carbon nitride (g-c 3 N 4 ) has been widely studied owing to the excellent optical, thermal and electrical characteristics and low cost. In this work, carbon nanofibers (CNFs) were used as a supporter to prepare cobaltite oxide (Co 3 O 4 ) doped g-c 3 N 4, Co 3 O 4 /g- C 3 N 4 /CNF S was used as binder-free and conductive-free electrode materials for supercapacitor. The specific methods were as follows: CNFs was prepared by electrospinning combined with high temperature calcining technology, and the composite materials that graphite carbon nitride/carbon nanofibers (g-c 3 N 4 /CNFs) was prepared by high-temperature pyrolysis of melamine powder and the obtained g-c 3 N 4 was deposited on CNFs by the vapor deposition. Then we prepared Co 3 O 4 /g-c 3 N 4 /CNF S electrode materials via a facile hydrothermal method, the g-c 3 N 4 /CNFs was impregnated in specified amount of CoCl 2 6H 2 O solution, followed by the addition of urea, and the solution was transferred into a Teflon-lined autoclave. Finally, the sample was calcined in air atmosphere. The results (Fig. 1A, B, C, D) showed that Co 3 O 4 /g-c 3 N 4 /CNF S was successfully prepared and used as binder-free and conductive-free electrode materials for supercapacitor. Fig. 1. (A) FE-SEM of CNFs; (B) FE-SEM of g-c 3 N 4 /CNFs; (C) FE-SEM of Co 3 O 4 /g- C 3 N 4 /CNF S ; (D) EDX spectroscopy of Co 3 O 4 /g-c 3 N 4 /CNF S ; (E) CV curves of Co 3 O 4 /g- C 3 N 4 /CNF S electrode at different scan rate. [1] Nan Wang, Xinjun Li. Facile synthesis of CoO nanorod/c 3 N 4 heterostructure photocatalyst for an enhanced pure water splitting activity [J]. Inorganic Chemistry Communications, 2018, 92: [2] Ming Wu, Junmin Yan, Xuewei Zhang, et al. Synthesis of g-c 3 N 4 with heating acetic acid treated melamine and its photocatalytic activity for hydrogen evolution [J]. Applied Surface Science, 2015, 354:

249 Structure and properties comparison of SiO 2 based flexible fiber membranes Zhuo Chen, Shengjuan Ma, Zidong Zhao, Fengzhu Lv Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing, , P. R. China Flexible and high mechanical strength electrospuns, especially total inorganic spuns, have plenty of applications in different fields. Amorphous SiO 2 is one kind of support for preparation of flexible and high mechanical strength electrospuns [1]. So the precursor of SiO 2 was electrospinned with BaTiO 3, Ti(OBu) 4, and Bi(NO 3 ) 3 and then calcinated under almost the same conditions to prepare composite films. As the same preparation conditions, all the samples with the feed ratio of Si to the other component being 1 could form long fibers confirmed by SEM (Fig.1). But the XRD patterns showed metastable Bi 2 SiO 5 formed in the system of containing the precursor of SiO 2 and Bi(NO 3 ) 3 [2] rather than the simple connection of Si-OH with Ti-OH in the system containing the precursor of SiO 2 and Ti(OBu) 4 due to the rapid condensation and migration ability of Bi-O unit. The structure difference endowed the resultant membranes had different photocatalytic and dielectric properties. Fig.1 SEM of SiO 2 BaTiO 3 (a), SiO 2 TiO 2 (b), SiO 2 Bi 2 SiO 5 (c) and Bi 2 SiO 5 (d). Key words: electrospin, photocatalytic, flexible, SiO 2 Acknowledgements: This work was supported by the Fundamental Research Funds for the Central Universities ( and ). [1] Liu LP, Lv FZ, Li PG, et al. Preparation of ultra-low dielectric constant silica/polyimide nanofiber membranes by electrospinning[j]. Composites Part A, 2016, 84: [2] Lu HJ, Hao Q, Chen T, et al. A high-performance Bi 2 O 3 /Bi 2 SiO 5 p-n heterojunction photocatalyst induced by phase transition of Bi 2 O 3 [J]. Applied Catalysis B-Environmental, 2018, 237:59-67.

250 Preparation of polyacrylonitrile/w composite nanofiber film with high photocatalytic performance Yuying Ma, Dayong He, Ce Wang Alan G. MacDiarmid Institute, College of Chemistry, Jilin University, P.O.Box ,Changchun, China With the increasing environmental problems, the use of oxide semiconductor photocatalysts to degrade organic matter in wastewater under solar light has become a hot issue in the field of water purification. There are some non-stoichiometric tungsten oxides containing oxygen defects during the preparation of tungsten oxide. Among them,w 18 O 49, which has the maximum number of oxygen deficiency, has a large amount of free electrons on its surface to form a stable Magneli phase. [1] However, most of the current dye-degrading photocatalysts are powders, and thus it is not easy to recover and reuse the catalyst. [2] In this work, we prepared W /PAN composite nanofiber film by electrospinning. As a growth template of W 18 O 49, PAN nanofibers can effectively improve the specific surface area of the catalyst in contact with visible light, and further enhance the performance of the catalytic dye. The product was charaterzed by X-ray diffractometer and field emission scanning electron microscope. (fig.1)it was found that the monoclinic phase W 18 O 49 with a regular octahedral crystal was successfully grown on the surface of the PAN nanofiber. Rhodamine B was used as an example to test its photocatalytic performance, indicating that the composite has excellent photocatalytic activity. With xenon lamp as the light source, the dye degradation rate can reach more than 99% after photocatalysis for 4h (fig.2). We will further regulate the crystal morphology of W 18 O 49 and further enhance its photocatalytic ability. Key Words: Composite material; Electrospinning; Photocatalytic ; Water treatment Acknowledgements: The authors are thankful for funds from National Natural Science Foundation of China (NSFDYS: and ). [1] Liu D, Li G, Zhao C, et al. WO 3 x for Rapid Adsorption and Full-Spectrum-Responsive Photocatalytic Activities[J]. Journal of Materials Science: Materials in Electronics, 2018, 29(17): [2] Xu M, Jia S, Li H, et al. In-situ Growth of Carbon Clothes for Flexible-Easy-Recycled Photocatalysts with High Performance[J]. Materials Letters, 2018, 230:

251 4.7 Nanofiber for energy

252 Electrospun Carbon Nanofibers-Based Supercapacitor Electrode Materials Guangdi Nie 1, Yaxue Luan 2, Xinwei Zhao 2, Yunze Long 2, Xin Ning 1 1 Industrial Research Institute of Nonwovens & Technical Textiles, College of Textiles and Clothing, Qingdao University, Qingdao, , P. R. China. 2 Collaborative Innovation Center for Nanomaterials & Devices, College of Physics, Qingdao University, Qingdao, , P. R. China. Carbon nanofibers (CNFs) are generally prepared by the high-temperature carbonization of electrospun polymer fibers, such as polyacrylonitrile (PAN), polyimide (PI), polyvinylpyrrolidone (PVP), poly(vinyl alcohol) (PVA), poly(methyl methacrylate) (PMMA), cellulose, etc. Among them, electrospun PAN nanofibers are the most commonly used carbon resources for producing CNFs owing to their high carbon yield as well as excellent thermal stability [1,2]. However, the conductivity and specific surface area of the conventional electrospun CNFs are usually significantly lower than those of graphene and carbon nanotubes, thus leading to the poorer electrochemical performance as supercapacitor electrode materials. Herein, we demonstrated the modification of electrospun CNFs from the aspects of increasing graphitization degree, tailoring pore structure, chemical activation, and introducing heteroatoms to improve their capacitive property. At present, we have successfully fabricated nitrogen-doped CNFs and activated porous CNFs/SnO 2 composites, both of which exhibit superior electrochemical performance to the bare CNFs electrode with larger specific capacitance, better rate capability, and excellent flexibility. It is believed that these regulation methods can be readily extended to the synthesis of other carbon nanomaterials for energy storage applications. Figure 1. Illustration of the nitrogen-doped CNFs and activated porous CNFs/SnO 2 composites with excellent flexibility. Key Words: Electrospinning, Carbon Nanofibers, Supercapacitors, Electrode Materials Acknowledgements: This work was financially supported by the research grant from China Postdoctoral Science Foundation (2018M630745). [1] Lu X F, Wang C, Favier F, et al. Electrospun nanomaterials for supercapacitor electrodes: designed architectures and electrochemical performance [J]. Adv. Energy Mater., 2017, 7(2): [2] Nie G D, Zhu Y, Tian D, et al. Research progress in the electrospun nanofiber-based supercapacitor electrode materials [J]. Chem. J. Chinese Universities, 2018, 39(7):

253 Multi-level SnO Nanofibers as High-Rate and Long-Life Anode Material for Lithium-ion Batteries Songwei Gao, NüWang, Zhimin Cui, Yong Zhao * Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, Beijing Key Laboratory of Bioinspired Energy Materials and Devices, School of Chemistry, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, , P. R. China. The rational design of multi-leveled composite nanofibers is of great importance to the highmagnification and long-cycle tin-based electrode materials. [1, 2] We can precisely design multi-leveled nanofibers of S-SnO H-SnO and WIT-SnO nanofibers by precisely regulating the annealing time and temperature. Especially, the WIT-SnO nanofibers have multiple shells and cavities, which can provide large specific surface area, more oxidation and reduction sites, and increase the effective contact area of electrolyte with electrode materials. More importantly, it can effectively alleviate the volume expansion and pulverization of tin-based electrode materials, and greatly improve the recycling performance of batteries. When used as the anode materials for lithiumion batteries, a specific capacity of 950 ma h g -1 at a current rate of 1 C for the 1500th cycle. Key Words: Multi-level nanofiber, electrospinning, tin-based materials, lithium-ion batteries [1] Lou X W, Li C M, Archer L A. Designed Synthesis of Coaxial SnO Hollow Nanospheres for Highly Reversible Lithium Storage [J]. Adv. Mater., 2009, 21(24): [2] Xia L, Wang S Q, Liu G X, et al. Flexible SnO 2 /N-Doped Carbon Nanofiber Films as Integrated Electrodes for Lithium-Ion Batteries with Superior Rate Capacity and Long Cycle Life [J]. Small, 2016, 12(7): 853.

254 N-doped flexible cross-linked electrospun carbon nanofibers with excellent rate capability and cycling stability for binder-free supercapacitor electrode Xiaodong Tian 1, Yiting He 1,2, Yan Song 1 1 CAS Key Laboratory of Carbon Materials, Institute of Coal Chemistry, Chinese Academy of Sciences, P.O. Box , Taiyuan, PR China. 2 Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences, P.O. Box , Beijing, PR China. Large contact resistance and long charge transfer path are two obstacles for conventional electrospun carbon nanofibers due to the insufficient physical contact among themselves, which limits the electrochemical performance at high rate [1]. In this regard, herein, by simply controlling the preoxidation degree of electrospun pitch/pan bending nanofibers, N -doped flexible cross-linked carbon nanofiber nonwoven network (CLCF) was fabricated successfully. In contrast to previous literatures, our work demonstrates a new approach to prepare cross-linked structure by taking the advantage of the merits of pitch without the utilization of cross-linking agents [2]. Owing to the synergistic effect of effective contact of nanofibers, short charge transfer channels and heteroatom doping, the CLCF electrode exhibits improved rate performance and stable lifespan. It delievers a high capacity of 160 F g -1 even at 100 A g -1 (85.6% of its initial capacity of 1 A g -1 ) along with the capacitance retention of 97.5% over cycles. This work demonstrates a new approach to prepare cross-linked electrospun nanofibers. Key Words: Electrospinning, Pitch/PAN bends, Cross-linked structure, Supercapacitor Acknowledgements: This work was financially supported by the National Natural Science Foundation of China (No. U , No. U ), the Key R & D Program of Shanxi Province (No D112007) and Shanxi Natural Science Foundation (No D221371). [1] Chen L-F, Feng Y, Liang H-W, et al. Macroscopic-Scale Three-Dimensional Carbon Nanofiber Architectures for Electrochemical Energy Storage Devices [J]. Advanced Energy Materials, 2017, 7 (23): [2] Jeong J H, Kim B-H. Synergistic Effects of Pitch and Poly(methyl methacrylate) on the Morphological and Capacitive Properties of MnO 2 /carbon Nanofiber Composites [J]. Journal of Electroanalytical Chemistry, 2018, 809:

255 Fabrication of metal-organic frameworks on electrospun nanofibers and their derivatives for high-performance supercapacitor Di Tian, Xiaofeng Lu*, Yun Zhu, Meixuan Li, Ce Wang* Alan G. MacDiarmid Institute, College of Chemistry, Jilin University, Changchun, , P. R. China. The environmental pollution and resource depletion have promoted the development of supercapacitors as one of the most promising devices for next-generation electric applications. [1] Recently, metal-organic framework nanosheets have drawn continuous attention because of their chemical components, adjustable pores and intriguing morphologies. In order to obtain a high-performance electrode materials, a facile strategy is developed to grow metal-organic framework nanosheets on electrospun nanofibers as supercapacitor electrode materials, exhibiting a high capacitance of F g 1 at a current density of 0.5 A g 1 and excellent cycling stabilities over cycles. [2] Through a specific carbonization process, the metal-organic framework based hybrids are preserved to produce a porous metal doped carbon material with the improved rate performance and a great prospect for cathode materials. Furthermore, an asymmetric solid-state supercapacitor device is assembled using the metal-organic framework based hybrids and metal doped carbon materials as anode and cathode materials, respectively. The maximum energy density of 51.4 Wh kg 1 with a power density of W kg 1 is achieved, which is superior to many previous reports, revealing a promising prospect for the novel high-performance asymmetric supercapacitor. Scheme illustration for the fabrication of 2D metal-organic frameworks on electrospun nanofibers and their derived metal doped carbon materials for an high-performance asymmetric supercapacitor. Key Words: electrospun, MOF, supercapacitor, carbon nanofibers. Acknowledgements: This work was supported by the National Natural Science Foundation of China (No , , and ). [2] Tian D, Lu X, Wang C, et al. Fabrication of two-dimensional metal-organic frameworks on electrospun nanofibers and their derived metal doped carbon nanofibers for an advanced asymmetric supercapacitor with a high energy density [J]. J. Power Sources, 2019, 413: [1] Lu X, Wang C, Pinna N, et al. Electrospun Nanomaterials for Supercapacitor Electrodes: Designed Architectures and Electrochemical Performance [J]. Adv. Energy Mater. 2017, 7:

256 Electrospun Ni-Mo 2 C nanoparticles embedded on carbon nanofibers as an efficient counter electrode for dye-sensitized solar cells Ju Qiu, Xiaofeng Lu, Dayong He, Yuying Ma, Nan Zhang, Bolun Sun, and Ce Wang Alan G. MacDiarmid Institute, College of Chemistry, Jilin University, P.O.Box , Changchun, China. In the past two decades considerable scientific and industrial attention has been focused on dyesensitized solar cells (DSSCs) because of the environmental friendliness, low cost, and simple preparation procedures for various photovoltaic devices. Counter electrode (CE) plays an important role in DSSC. Electron transfer from external circuit to redox couple is mediated and facilitated by it to complete the DSSC circuit. Platinum (Pt) is widely employed as CE in DSSC. However, due to its scarcity and high cost, efforts are being made to replace Pt. In this work, Ni-Mo 2 C nanoparticles embedded on carbon nanofibers (CNFs) are prepared by electrospinning technique and used as CE material for DSSC application. The structural and morphological properties were explored by FE- SEM, XRD, and TEM studies. The results of cyclic voltammetry (CV), electrochemical impedance and Tafel polarization studies revealed that (Ni-Mo 2 C)/CNFs-2 demonstrated superior electrocatalytic activity, electrochemical stability, low charge transfer resistance (Rct) and high exchange current density for the reduction of triiodide (I 3 - ). Furthermore, it was observed that DSSC fabricated using (Ni-Mo 2 C)/CNFs-2 as counter electrode had achieved power conversion efficiency (PCE) that is almost comparable to the same fabricated using std. Pt. This is due to the prepared CNFs' randomly oriented and large surface area, interconnected porous morphology with graphitized structure, which enhanced the contact with a large quantity of ionic liquid electrolyte, leading to a faster redox kinetics of I 3 - /I -. This study revealed that (Ni-Mo 2 C)/CNFs-2 could be used as a low-cost and efficient counter electrode material for DSSC. Key Words: electrospinning, carbon nanofibers, Mo 2 C, Ni, dye-sensitized solar cells. Acknowledgements: This work was financially supported by the National Natural Science Foundation of China ( , , and ). [1] Wu M, Lin X, Hagfeldt A, et al. Low-cost Molybdenum Carbide and Tungsten Carbide Counter Electrodes for Dye Sensitized Solar Cells[J]. Angewandte chemie-international editon, 2011, 123(15): [2] Zhou Z, Sigdel S, Gong J, et al. Graphene-Beaded Carbon Nanofibers with Incorporated Ni Nanoparticles as Efficient Counter-Electrode for Dye-Sensitized Solar Cells [J]. Nano Energy, 2016, 22:

257 One-Dimensional MOF-Based Derivatives with Enhanced ORR Activity Chuan-Ling Zhang*, Jiang-Tao Liu, Zhi-Hao Jiang, and Fu-Hu Cao* Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei , China. Exploring new materials with high efficiency and durability is the major requirement in the field of sustainable energy conversion and storage systems. MOF derived catalysts are emerged as the finest materials with tunable properties and activities for the energy conversion and storage. 1 In particular, the capability of self-assembling nanoparticles (NPs) into macroscopic assemblies that exhibit unique collective properties has opened up new and exciting opportunities in the field of nanotechnology. 2 Herein, by directly electrospinning, bimetallic zeolitic imidazolate framework NPs (ZIFs), one subclass of MOF, were assembled in a large amount and were densely aligned within the electrospun fibers. After a carbonization process, the electrospun nanofibers were derived into Co/N doped porous carbon nanofibers. The ORR performances of the derived porous carbon materials were investigated. As expected, such doped porous carbon nanofibers exhibited excellent electrocatalytic performances without any etching or other activating process, even the sample with Zn/Co=5 showed better activity and durability as well as methanol tolerance than that of commercial 20 wt% Pt/C, due to the assemble effect of MOFs within the electrospun fibers, which was beneficial to make the derivatives have high surface area as well as uniform N and Co dopant, and one dimensional porous structure significantly enhanced the mass transfer and exposure of active sites. 3 The experiment results showed the electrospun samples had the best ORR performances, confirming the advantages of the one-dimensional structure constructed by electrospinning. Key Words: (MOF, electrospinning, ORR, porous carbon nanofibers, assembly) Acknowledgements: We acknowledge the funding support from the National Natural Science Foundation of China (Grants ), the Fundamental Research Funds for the Central Universities (JZ2018HGTB0250), and the open project of Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering (Grant No /007). [1] Wu HB, Lou XW. Metal-organic frameworks and their derived materials forelectrochemical energy storage and conversion: Promises and challenges[j]. Science Advances 2017, 3(12), eaap9252. [2] Zhang C-L, Yu S-H. Nanoparticles meet electrospinning: recent advances and future prospects[j]. Chem Soc Rev 2014, 43(13): [3] Zhang C-L, Lu B-R, Cao F-H, Wu Z-Y, Zhang W, Cong H-P, et al.electrospunmetalorganic framework nanoparticle fibers and their derived electrocatalysts for oxygen reduction reaction[j]. Nano Energy 2019, 55:

258 Oxygen Vacancy Tuning using Metal Organic Framework Templates in One-Dimensional Metal Oxides for Battery Applications Won-Tae Koo 1,2, Jun Young Cheong 2, Chanhoon Kim 2, Ji-Won Jung 2, and Il-Doo Kim 1,2 1 Advanced Nanosensor Research Center, KAIST Institute for Nanocentury, Daejeon 34141, Republic of Korea 2 Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea. Facile synthesis of rationally designed nanostructured electrode materials with high reversible capacity is highly critical to meet ever-increasing demands for lithium-ion batteries (LIBs) [1,2]. In this work, we employed oxygen vacancy tuning by using metal organic framework (MOF) templates into one-dimensional nanostructures by electrospinning and subsequent calcination. The introduction of Co based zeolite imidazole framework (ZIF-67) resulted in the abundant oxygen vacancies, which induce not only more active sites for Li storage but also enhanced electric conductivity. Moreover, abundant mesoporous sites were formed by the decomposition of ZIF-67, which are present both in and outside of the resultant SnO 2 -Co 3 O 4 NFs. Attributed to the creation of vacancy sites along with the synergistic effects of SnO 2 and Co 3 O 4, SnO 2 -Co 3 O 4 NFs exhibit an excellent reversible capacity for 300 cycles (1287 mah g 1 at a current density of 500 ma g 1 ) along with superior rate capabilities and improved initial coulombic efficiency (I.C.E) compared with pristine SnO 2 NFs. This is an early report on utilizing MOF structure as the defect formation platform into one-dimensional nanostructures, which is expected to result in superior electrochemical performances required for advanced electrodes. Key Words: Nanofibers, Metal-organic frameworks, Anodes, Li-ion batteries [1] Croguennec L, Palacin M R. A Recent Achievements on Inorganic Electrode Materials for Lithium Ion Batteries [J]. Journal of the American Chemical Society, 2015, 137: [2] Tarascon J-M, Armand M. Issues and Challenges Facing Rechargeable Lithium Batteries [J]. Nature, 2001, 414:

259 Fabrication and Characterization of 1D Porous Carbon Nanofibers as Efficient Electrocatalyst of Water Splitting Jixin Li, Zhixiang Cui, Junhui Si College of Materials Science and Engineering, Fujian University of Technology, Fuzhou, China. E- Water electrolysis is of great importance for high-efficient hydrogen production. Replacing noble metalbased electrocatalysts by highly efficient and inexpensive non-noble metal based catalysts is critical for the practical application of these technologies. In this study, the 1D porous carbon nanofibers were prepared by a electrospinning technology and subsequent thermal treatments as the wide-ph HER and OER electrocatalysts. Owning to the prominent merits of strong synergistic relationships between Co and CoP nanoparticles, N-doped carbon configuration, and the interconnected 1D porous carbon nanofibers, the nanofibers exhibit robust HER and OER activity with affording an low overpotential of 155 mv at 10 ma cm -2 in 0.5 M H 2 SO 4 for HER and 156 mv at 10 ma cm -2 in 1.0 M KOH for OER with a small Tafel slope value of 79.2 mv dec -1, respectively. Therefore, this work provides a favorable guidance for exploring executable strategies to improve catalyst activity. Keyword: Hydrogen evolution reaction, Electrospinning, Electrocatalysis, Water splitting

260 Preparation of double-layer nanofiber fabric is applied in triboelectric nanogenerators Xuejiao Tao 1, Yuman Zhou 1,2, Fang Li 1, Kai Weng 1, Jianxin He 1,2 1 Zhongyuan University of Technology Textile Institute, Zhengzhou,Postal Code ,The China. E- mail: 2 Collaborative Innovation Center of Textile and Garment Industry, Henan Province, Zhengzhou , China.) Abstract: With the rapid development of wearable electronic products, wearable friction generator (TENG) has become a research hotspot because it can converts external mechanical energy This paper proposes a new method to construct TENG based on PU/PVDF double layer Nano-fiber fabric. The double layer fabric is composed of PU and PVDF single-layer fabrics, which are knitted through PU and PVDF nanofiber core-spun yarn. The core-spun yarn is prepared via coated PU and PVDF nanofiber on core yarn of copper wire. The open-circuit voltage(voc), short-circuit current(isc), washability, and cyclic performance of the TENG was researched. Results show that, the peak V oc values achieved 100V,the peak I sc values achieved 80μA. Moreover, the output performance would not be affected. after washing and electrical properties are still maintained after 2000 cycles. This research can significantly improve the output performance of wearable fabric generator and greatly promote the application performance of TENG in self-powered wearable textiles. Figure 1 (a) Optical images of the TENG, (b) PVDF nanofiber cross section(the inset is highmagnification SEM of (b)), (c)working principle of the triboelectric nanogenerator, (d) SEM images of the low-magnification, (e) High-magnification of the PU nanofiber core yarn, (f) lighted up LEDs of TENG, (g) Output short circuit current with different number of fingers. Key words: triboelectric nanogenerators, wearable, self-powered [1] Yu A, Pu X, Wen R, et al. Core Shell-Yarn-Based Triboelectric Nanogenerator Textiles as Power Cloths[J]. ACS Nano, 2017:acsnano.7b [2] Zhu M, Huang Y, Ng W S, et al. 3D spacer fabric based multifunctional triboelectric nanogenerator with great feasibility for mechanized large-scale production[j]. Nano Energy, 2016, 27:

261 Preparation and properties of flexible supercapacitors based on graphene/polyimide carbon fiber Fang Li 1, Xuejiao Tao 1,Kai Weng 1,Yuman Zhou 1, Fan Liu 1,2,Weili Shao 1,2,Jianxin He 1,2 1 Zhongyuan University of Technology Textile Institute, Zhengzhou, Postal Code ,The China. 2 Collaborative Innovation Center of Textile and Garment Industry, Henan Province, Zhengzhou , China.) Abstract: As a new generation of energy storage components, flexible linear supercapacitors can be woven into functional garments, which is of great value for the development of flexible wearable electronic devices. However, the current challenges faced by supercapacitors are the problems of poor flexibility and low energy density. Here, we propose a simple, effective and low-cost preparation method to construct a one-dimensional flexible electrode with high energy density and power density. The yarn material is assembled into a fiber-type supercapacitor. Using carbon fiber as the core yarn, the graphene oxide/polyimide nanofiber core-spun yarn was prepared by electrospinning nanofiber yarn forming technology, and the graphene was reduced by high-temperature carbonization and the polypyrrole was polymerized in situ, and H 2 SO 4 /PVA was used as the gel. The gel electrolyte is constructed as a supercapacitor. The structure and properties of the nanofibers are well characterized by different technical means. The results show that the nanofibers can be coated on the surface of the carbon fiber, which provides a larger space and position for the polymerization of the subsequent conductive materials, which is beneficial to the improvement of the supercapacitor. Electrochemical performance. When the doping amount of graphene oxide was 0.8% of the solute, the energy density and power density of the obtained linear supercapacitor were mwh/cm3 and 836 mw/cm3, respectively. In addition, the composite electrode yarn has the advantages of good flexibility, good bending fatigue resistance, and good cycle stability, and can be integrated into the power supply of various wearable electronic devices.

262 Manganese oxide-carbon nanofiber composites as electrocatalysts for Zinc- Air batteries Su-Ho Cho 1, Min Soo Kim 1, Ji-Won Jung 1, and Il-Doo Kim 1 1 Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, Daehak-Ro 291 Yuseong-gu, Daejeon Republic of Korea. To meet the energy needs of energy consumption and CO 2 emissions, new energy systems have been developed through numerous research and efforts. In particular, there is a growing interest in new energy storage systems due to the development of renewable energy. To this end, many materials have been studied, particularly transition metal oxides (TMOs) have electrochemical activity and have been used in a variety of fields such as metal-ion batteries, fuel-cell, electrocatalysis, and sensors. Among them, manganese oxide (MnOx) has excellent physical and chemical properties due to have various multivalent phases. The MnOx can be used as electrocatalyst for oxygen evolution and reduction under aqueous environment, and the zinc-air batteries with aqueous electrolyte shows high safety and eco-friendly properties for future energy storage technologies. In this study, we demonstrate manganese oxide (MnOx)-carbon nanocomposites as electrodes for zinc-air batteries. The method of preparing the MnOx-carbon nanocomposite electrode is simple. Carbon nanofibers are prepared by electrospinning and subsequent calcination process. Using these carbon nanofiberspotassium permanganate (KMnO 4 ) is a strong oxidant and oxidizes carbon to carbon dioxide (CO 2 ) and MnOx nanostructures synthesized by reducing KMnO 4 on the carbon surface. Through the redox reaction, we prepared MnOx covered carbon fiber nanocomposite as cataylsts materials for zinc-air batteries. The carbon provides high electrical conductivity and supports formation sites for MnOx. The nanofiber web structure not only allow the fast electrolyte penetration through the numerous pores among fibers to achieve high rate capability, but also, support large amount of active sites for electrolysis. In this work, we suggest a simple way based on electrospinning to synthesized MnOx-carbon nanocomposite as electrode materials for zinc-air batteries. Key Words: Electrospinning, Manganese oxide, Electrocatalysts, Zinc-air batteries Acknowledgements: This work was supported by Korea CCS R&D Center (KCRC) grant funded by the Korea government (Ministry of Science, ICT & Future Planning) (No. 2014M1A8A ), [1] Bao Liu, Yinlun Sun, Li Liu, et al. Advances in Manganese-Based Oxides Cathodic Electrocatalysts for Li Air Batteries [J]. Adv. Funct. Mater., 2018, 28(15): [2] Ji-Won Jung, Cho-Long Lee, Sunmoon Yu, Il-Doo Kim. Electrospun nanofibers as a platform for advanced secondary batteries: a comprehensive review [J]. Mater. Chem. A, 2016, 4:

263 Carbon dot modified TiO 2 nanofiber membrane with optimized morphology and optical property Ningxiao Gao 1, Yulong Xu 1, Libing Huang 1, Jinghui Song 1 Hengwei Hu 1 and Yong Liu 2, 1 College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, P.O.Box 106, Beijing ,China. 2 College of Material Science and Engineering, Beijing University of Chemical Technology, P.O.Box 106, Beijing ,China. Dye-sensitized solar cells (DSSCs) have received widespread attention due to their low cost, ease of operation, and lower contamination compared to other solar cells [1-3]. In this study, Silanefunctionalized and Nitrogen-doped carbon dots doping were used to improve the electron transport efficiency of Titanium dioxide (TiO 2 ) nanofibers and improve the photovoltaic performance of DSSCs. TiO 2 /PVP composite nanofibers with good morphology were prepared by electrospinning using titanium isopropoxide and PVP in ethanol. The thermogravimetric test results were used to determine the sintering temperature of 550, and then the composite fiber film was sintered at to 550 prepare TiO 2 fiber. The XRD test showed that the sintered TiO 2 fibers were anatase crystal form. Silanefunctionalized carbon dots were prepared by one-step pyrolysis of anhydrous citric acid and AEAPMS silane. N-doped carbon dots were sensitized with anhydrous citric acid and Urea. The TiO 2 fiber film was immersed in different concentrations of carbon/ethanol solution to be modified. SEM was used to characterized the morphology of fiber membranes (before and after sintering) doped with different concentration of carbon dots solution. FTIR and XRD proved successful doping of carbon dots. UVvis showed the optimized optical properties of the TiO 2 fiber doped with carbon dot. Carbon dot modified TiO 2 fibers will have certain application value in improving the light utilization efficiency of dye-sensitized solar cells. Key Words: Electrospin, Carbon dots, TiO 2, Dye-sensitized solar cells Acknowledgements: This research was funded by the National Natural Science Foundation of China ( ). [1] Ma L, Kang J, Liu Y, et al. Economical and highly efficient Pt-free counter electrode for dyesensitized solar cells[j]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2019, 566: [2] Salam Z, Vijayakumar E, Subramania A, et al. Graphene quantum dots decorated electrospun TiO2 nanofibers as an effective photoanode for dye sensitized solar cells[j]. Solar Energy Materials and Solar Cells, 2015, 143: [3] Sun Q, Li Y F, Jie D, et al. Improving the efficiency of dye-sensitized solar cells by photoanode surface modifications [J]. Science China Materials, 2016, 59(10):

264 4.8 Nanofiber for photonic and electronic

265 Making functional electrospun poly(methyl methacrylate)-perovskite nanocrystal fibrous nanocomposites Georgia Papaparaskeva 1, Paris Papagiorgis 2, Andreas Manoli 2, Grigorios Itskos 2, Caterina Bernasconi 3,4, Maryna I. Bodnarchuk 3,4, Maksym V. Kovalenko 3,4 and Theodora Krasia- Christoforou 1 1 Department of Mechanical and Manufacturing Engineering and 2 Department of Physics University of Cyprus, P.O.Box 20537, 1678, Nicosia, CYPRUS 3 Empa Swiss Federal Laboratories for Materials Science and Technology, CH-8600, Dübendorf, Switzerland 4 Laboratory for Inorganic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, CH-8093 Zürich, Switzerland Lead halide perovskites [APbX 3, X = Cl, Br, I] are semiconductor materials exhibiting unique optical and electrical properties that show great potential for a wide range of applications including LEDs, photovoltaics, lasers and photodetectors [1, 2]. Colloidal nanocrystals of lead halide perovskites have emerged as outstanding light emitting materials, exhibiting widely tunable emission across the visible with narrow linewidths and high emission quantum yields [3, 4]. The encapsulation of perovskite nanocrystals within a functional organic polymer matrix can further enhance their stability, versatility and optical performance. Very recently, we have demonstrated the fabrication of robust fibrous nanocomposite emitters based on poly(methyl methacrylate) (PMMA) electrospun fibers with embedded CsPbBr 3 and FAPbBr 3 perovskite nanocrystals [3]. The fabrication process involved the mixing of the perovskite colloidal solution (prepared in toluene) with the polymer solution (prepared in CHCl 3 ) followed by electrospinning. However, the use of two different solvents prevented the incorporation of high % wt. of the nanocrystals within the polymer fibers. More precisely, in solvent mixtures containing a high ratio of the toluene nanocrystal solution, emulsions with viscosity properties not suitable for producing bead-free fibers by electrospinning were generated. For overcoming this problem, in the present work a systematic parametric study was carried out enabling the production of PMMA fibers starting from a series of THF:toluene homogeneous solvent mixtures of various solvent ratios. The new approach enabled the generation of nanocrystal-sensitized PMMA fibers with high nanocrystal loadings for potential textile-based light emitting applications. The composition, morphology and optical properties of the obtained fibrous light emitting nanocomposites are discussed. Keywords: Electrospun nanocomposite fibers, perovskite nanocrystals, fluorescent fibrous nanocomposites. [1] Wei I, Cheng Z, Lin J, An overview on enhancing the stability of lead halide perovskite quantum dots and their applications in phosphor-converted LEDs [J]. Chemical Society Reviews, 2019, 48, [2] Zhao Z, Gu F, Rao H, et al., Metal Halide Perovskite Materials for Solar Cells with Long Term Stability [J]. Advanced Energy Materials, 2019, 9, Article Number: [3] M. V.Kovalenko, L. Protesescu, M. I. Bodnarchuk, Properties and potential optoelectronic applications of lead halide perovskite nanocrystals [J]. Science 358, (2017), [4] Q. A. Akkerman; G. Rainò; M. V. Kovalenko; L. Manna, Genesis, challenges and opportunities for colloidal lead halide perovskite nanocrystals [J] Nature Materials 17, (2018), 394. [5] Paris Papagiorgis, Andreas Manoli, Androniki Alexiou et al., Robust Hydrophobic and Hydrophilic Polymer Fibers Sensitized by Inorganic and Hybrid Lead Halide Perovskite Nanocrystal Emitters [J.] Frontiers in Chemistry Section Nanoscience, 2019, just accepted manuscript. doi: /fchem

266 Gyrospun antimicrobial nanoparticle loaded fibrous polymeric filters by okeks Samuel uchenna and ezello chimezie(unilorin,nigeria) A one step approach to prepare hybrid nanoparticle embedded polymer fibres using pressurised gyration is presented. Two types of novel antimicrobial nanoparticles and poly(methylmethacrylate) polymer were used in this work. X-ray diffraction analysis of the nanoparticles revealed Ag, Cu and W are the main elements present in them. The concentration of the polymer solution and the nanoparticle concentration had a significant influence on the fibre diameter, pore size and morphology. Fibres with a diameter in the range of 6 20 μm were spun using 20 wt% polymer solutions containing 0.1, 0.25 and 0.5 wt% nanoparticles under 0.3 MPa working pressure and a rotational speed of 36,000 rpm. Continuous, bead-free fibre morphologies were obtained for each case. The pore size in the fibres varied between 36 and 300 nm. Successful incorporation of the nanoparticles in polymer fibres was confirmed by energy dispersive x-ray analysis. The fibres were also gyrospun on to metallic discs to prepare filters which were tested for their antibacterial activity on a suspension of Pseudomonas aeruginosa. Nanoparticle loaded fibres showed higher antibacterial efficacy than pure poly(methylmethacrylate) fibres. KEYWORDS: Gyrospun, fibres, nanoparticle, metallic

267 Novel transparent and self-powered UV photodetector based on PANI/ZnO nanofiber array heterojunction Pingping Yu 1, Yanfeng Jiang 1 1 School of internet of things engineering, Jiangnan University. The ultraviolet (UV) photodetector has a widely application in missile warning, medical/biological analysis and so on [1]. Without the need of an external energy supply, the heterojunction devices with a built-in potential difference acting as a driving force exhibit high sensivity and high detectivity, which is an active demand of the UV detections. UV photodetector based on low-dimensional ZnO semiconductors have been attracted much attention. There still exist the problem of low dark current and high on off ratio reported recently, ZnO nanowire-based UV detectors still suffer from slow response that eliminates their broader use in optoelectronic devices [2,3]. Herein, the pure ZnO nanofibers are prepared by electrospinning, combining with conducting polyaniline (PANI) to fabricate a novel self-powered UV photodetector based on PANI/ZnO nanofibers. The device exhibits a high on/off current ratio up to 10 3 at 360 nm under zero bias, and a short rise/decay time of 5.0/6.4s. Therefore, the low-cost fabrication technology may become a potential approach way for high performance UV photodetectors. Figure 1. (a) Optical miscroscopy iamge of ordered patterns of ZnO nanofibers, (b) PANI nanoarrays in the ZnO nanofibers, (c) I-V and (d) I-t curves of PANI/ZnO. Key Words: ZnO nanofiber, UV phototdetector, PANI, electrospin Acknowledgements: This work was supported by the National Natural Science Foundation of China ( ). [1] H. Chen, K. Liu, L. Hu, et al, New concept ultraviolet photodetectors [J]. Materials Today, 2015, 18: [2] Z. Zheng, L. Gan, J. Zhang, F. Zhuge, et al, An enhanced UV-Vis-NIR and flexible photodetector based on electrospun ZnO nanowire array/pbs quantum dots film heterostructure [J]. Advanced Science, 2017, 4, (1-8). [3] Z. Zheng, L. Gan, H. Li, et al, A fully transparent and flexible ultraviolet-visible photodetector based on controlled electrospun zno-cdo heterojunction nanofiber arrays [J]. Advanced Functional Materials, 2015, 25,

268 Anchoring CsPbBr 3 /Cs 4 PbBr 6 Perovskite Composites on Flexible Al 2 O 3 - La 2 O 3 Nanofibrous Membranes for Light-Emitting Diodes Weidong Han 1, Bin Ding 2,*, and Hakyong Kim 1,* 1 Department of BIN Convergence Technology, Chonbuk National University, 54596, Jeonju, South Korea. 2 Innovation Center for Textile Science and Technology, Donghua University, , Shanghai, China. Inorganic luminescent materials as one of the important high-performance materials have been widely used for industry and scientific research, mainly owing to their outstanding luminescence properties [1-2]. However, inorganic luminescent materials are typically brittle and inelastic, which greatly limit their use in practical applications, particularly in flexible optoelectronic devices. In this work, we show that a plum-pudding like CsPbBr 3 /Cs 4 PbBr 6 perovskite composites anchored onto Al 2 O 3 -La 2 O 3 (CCAL) nanofibrous membranes, which were synthesized via a facile electrospinning and subsequent supersaturated recrystallization process. The as-synthesized CCAL membranes exhibit outstanding mechanical flexibility and luminescence properties. Meanwhile, the crystal structure and luminous performance of the CCAL membranes were regulated by different molar ratios of CsBr/PbBr 2. The photoluminescence reached a maximum value for the CCAL membranes produced with a CsBr/PbBr 2 ratio of 1, and showed a narrow emission line-widths of 18 nm. Furthermore, we demonstrated the potential applications of the CCAL nanofibrous membranes in green light devices through a remote nanofibrous membranes packaging approach. A pure green emission is achieved with the CIE color coordinates of (0.28, 0.65). This facile strategy would open a new avenue to flexible inorganic luminescent materials for the lighting and backlight display industries. (a) SEM images of CCAL-1 nanofibrous membrane. (b) Images of CCAL-1 nanofibrous membrane under UV-light (365 nm) excitation. (c) The electroluminescence spectrum of a CCAL-1 membrane LEDs. Key Words: electrospinning, flexible Al 2 O 3 -La 2 O 3 nnaofibers, light-emitting diodes, perovskite crystals, sefl-assembly [1] Kim, Y. H.; Arunkumar, P.; Kim, B. Y., et al. A zero-thermal-quenching phosphor [J]. Nature Materials, 2017, 16(5): [2] Shang, M.; Li, C.; Lin, J. How to produce white light in a single-phase host? [J]. Chemical Society Reviews, 2014, 43(5):

269 Flexible Sandwich-like Electrically Conductive Nonwoven with Low Resistance and Air Permeability Qiang Gao, Andreas Greiner Macromolecular Chemistry and Bavarian Polymer Institute, University of Bayreuth, Universitätsstrasse 30, Bayreuth, Germany Flexible conductors are important for soft electronics, e.g. in sensors for monitoring body movements, tribolelectric generators, shape changeable soft robots, and flexible batteries. However, flexible conductors with large stretchable effective work interval and low resistance are still a challenge. We report here based on our previous work in the field [1] a flexible sandwich-like electrically conductive nonwovens with low resistance for use as conductor with excellent flexibility (Fig. 1) [2]. An electrospun layer is used as elastic substrate with effective working interval of 130% strain and as well as a conductive layer with a sheet resistance as low as <0.1 Ωm. Very limited joule heating is produce thanks to the low resistance of nonwovens. The flexible sandwich-like electrically conductive nonwovens possess pore structure, which present good air permeability. We believe this flexible sandwich-like electrically conductive nonwovens is a good candidate in the application of smart wearable devices and soft robots. Straight state Bending state Twisting state Stretching state Figure 1. Luminance of Blue LED under different state of flexible sandwich-like electrically conductive nonwovens Key Words: Electrospun nanofiber, flexible conductor, low resistance, conductive Acknowledgements: The authors acknowledge financial support by the China Scholarship Council Scholarships and by Deutsche Forschungsgemeinschaft (SFB 840, Project B). [1] S. Reich, M. Burgard, M. Langner, S. Jiang, X. Wang, S. Agarwal, B. Ding, J. Yu, A. Greiner, npj Flexible Electronics DOI: /s (2018). [2] Q. Gao, J. Zhu, X. Liao, S. Agarwal, A. Greiner, to be submitted.

270 3.9 Nanofiber for filtration

271 Design and Fabrication of Ordered Hollow Nanofiber Aerogel for Oil Adsorption Applications Yang Wu 1, Shiyi Cao 1, Jiajia Chen 1, Xiaowen Shi 1, Yumin Du 1, Hongbing Deng 1,* 1 Chitin Research and Development Center, School of Resource and Environmental Science, Wuhan University, Wuhan, Hubei, , China. Efficient, convenient, economical and environmentally friendly materials have always been the first choice for solving environmental problems. The nanomaterials derived from electrospun nanofibers can fully utilize the excellent surface effects of nanofibers and impart new properties to the materials to further broaden the application fields of nanofiber materials[1]. In this work, a hollow short polyacrylonitrile (PAN) nanofiber dispersion was obtained by combining the coaxial electrospinning technique with the homogenization technique. And under the action of directional freezing and high temperature crosslinking, the stable oriented hollow PAN nanofiber aerogel is obtained. The prepared hollow nanofiber aerogel is super-hydrophobic and super-lipophilic, and has an apparent density of only 12.16±1.43 mg/cm3. It can absorb oil of times its own mass, indicating its application prospects in solving crude oil pollution in water. Keywords: Hollow nanofiber, polyacrylonitrile, aerogel, oil adsorption. Acknowledgements: This work was supported by the National Natural Science Foundation of China (No & ) and the PetroChina Innovation Foundation (No. 2016D ), and partially supported by the Natural Science Foundation of Hubei Province of China (Team Project, No.2015CFA017) and the Fundamental Research Funds for the Central Universities of China (No kf0175). Reference: [1] Jian C, Zhang L, Peng W. Intelligent Environmental Nanomaterials[J]. Environmental Science Nano, 2018, 5(4): C7EN00760D.

272 Controllable Fabrication of Polyethersulfone/Polyacrylonitrile Electrospun Nanofiber Membranes with Groove Structure and Enhanced Filtration Performance for Ultrafine Particulates Jie Wang 1, Bin Wang 1 * 1 Beijing Key Laboratory of Clothing Materials R & D and Assessment, Beijing Engineering Research Center of Textile Nanofiber, School of Materials Science and Engineering, Beijing Institute of Fashion Technology, Beijing , China; Contact information: Abstract:As researchers strive to develop high-efficiency air filtration membranes with structural alternatives, the challenges and costs of processing often limit creative innovation. Here, we describe a powerful and economic strategy for fabricating groove structured polyethersulfone/polyacrylonitrile (PES/PAN) electrospun nanofiber, which is constructed by soaking in chloroform, extending the retention time of fine particles on the surface of fiber and improving the filtration performance. By simply varying the composition of precursor solutions, individual fibers within the PES/PAN nanofiber membrane can conformally be endowed with groove structure and rough surface, to form a high-performance membrane with filtration efficiency (98.999%) and pressure drop (186 Pa) for nm DOP aerosol particles. The results suggested that this cost-effective filter media could be used as promising candidates for a variety of potential applications in respiratory protection equipment and indoor air cleaner having high filtration efficiency and low pressure drop. Keywords: Electrospinning, Air Filtration, Groove structure, High-efficiency. Acknowledgements: This study was supported by National Natural Science Foundation of China ( , ), Beijing Excellent Talent Training Subsidy Program ( G089), Science and technology project of Beijing Municipal Education Commission (KM ), High Levels of Teachers' Team Construction Special Funds of Beijing Institute of Fashion Technology (BIFTQG201807, BIFTTD201903), Talent introduction program of Beijing Institute of Fashion Technology (2017A-19). [1] Li X, Wang N, Ding, B, et al. Electreted polyetherimide-silica fibrous membranes for enhanced filtration of fine particles [J]. J Colloid Interf. Sci. 439, [2] Dumée L F, Kong L, Schütz J A, et al. High efficiency poly(acrylonitrile) electrospun nanofiber membranes for airborne nanomaterials filtration [J]. Adv. Eng. Mater. 20,

273 Halloysite nanotubes and Fe 3 O 4 nanoparticles enhanced adsorption removal of heavy metal using electrospun membranes Lei Li 1, Feijun Wang 1, and Ziqiang Shao 1 1 Beijing Engineering Research Centre of Cellulose and Its Derivatives, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing , China. The contamination of heavy metal ions (HMIs) in water has become a globally environmental challenge, which is also a serious worldwide threat to human health. 1 In this study, magnetic nonwovens had been strategically prepared by immobilizing halloysite (Hal) nanotubes and Fe 3 O 4 nanoparticles on polyethylene oxide/chitosan (PEO/CS) composite fibers via electrospinning. TEM, XPS, XRD, FTIR, UV vis DRS, BET, and VSM analyses of the adsorbents were used to determine their structure and performance. The effect of organic-inorganic hybridization provided the asobtained adsorbents with uniform structure, superior pore structure, large specific surface area, and superparamagnetic properties. These nonwovens also exhibited high removal efficiency of different HMIs, and the adsorption capacity of cadmium, copper, lead and chrome onto the nonwoven was in order of Cr(VI) < Cd(II) < Cu(II) < Pb(II). The pseudo-first-order, pseudo-second-order and intraparticle diffusion kinetic models were employed to analyze the kinetic data, which suggested the chemisorption was distinct but the intraparticle-diffusion was not significant. The anti-anion interference capability and reusability of membranes for the removal of different HMIs were also determined, which indicated that the nanofibrous adsorbents were widely adaptable and reusable. In addition, the composite membranes showed high antibacterial activity for E. coli and S. aureus. Thus, these proficient inorganic-materials-doped magnetic nonwovens are suitable to employ as a heavy metal adsorbents with salient removal capacity. Scheme 1. Schematic representation of the preparation of composite nanofiber membrane, adsorption removal of heavy metals, and magnetic separation from aqueous system thereof. Key Words: Halloysite nanotubes, Fe 3 O 4, Heavy metal, Electrospinning, Antibacterial Acknowledgements: This study was financially supported by Beijing Natural Science Foundation ( ) and China Postdoctoral Science Foundation (2018M640124). [1] Aliabadi M, Irani M, Ismaeili J, Piri H, Parnian, M J, Electrospun nanofiber membrane of PEO/chitosan for the adsorption of nickel, cadmium, lead and copper ions from aqueous solution [J]. Chem. Eng. J. 2013, 220,

274 Preparation of the superhydrophobic/superoleophilic P(VDF-co- TFE)/SiO 2 membrane via electrospinning for efficient oil/water Separation Chunnuan Du, Jianxiang Yu,Guangming Wu 1 1 College of Materials Science&Engineering,Beijing Institute of Petrochemical Technology, Beijing, China. Abstract The nanofibrous poly(vinylidene fluoride-co-tetrafluoroethylene)(p(vdf-co-tfe))/sio 2 membrane on the non-woven fabrics with efficient oil and water separation was fabricated by electrospinning technique and heat treatment. The surface morphology of the membrane was characterized by Scanning Electron Microscope (SEM) and the results showed that the diameter of beads are about 2-5µm and the average diameter of film is nm. The contact angle is up to for water and nearly zero for oil(chloroform). The separation property of oil/water mixture was tested and the best efficiency is 98%. Furthermore, the electrospinning membrane has good adhesive force on non-woven fabrics. So the P(VDF-co-TFE) membrane fabricated by electrospinning offered new ideas about separating oil and water. Table1 The influence of the heat process on the adhesion ability of the membrane Sample Heat Addition Water contact angle Adhesion level ± ± SiO ± SiO ±2 2 Key Words: superhydrophobic, oil/water separation, membrane : [1] C.Wei, F.Dai, L.Lin.et al. Simplified and robust adhesive-free superhydrophobic SiO 2 - decorated PVDF membranes for efficient oil/water separation. J.Memb.Sci. 2018(555): [2] J. Wu,a Y. Ding,et al. Facile fabrication of nanofiber- and micro/nanosphere-coordinated PVDF membrane with ultrahigh permeability of viscous water-in-oil emulsions. Journal of Materials Chemistry A. 2018(6): [3]S.Qiu,L.Hou,J.Liu,et al. Hign-flux,continuous oil spill collection by using a hydrophobic/oleophilic nanofibrous container. RSC Advances. 2017(7):

275 Fabrication of Superhydrophilic/Underwater Superoleophobic Nanofiber Membranes by Electrospinning Yimin Zhang 1,Weitao Zhou 1, Jianxin He 1,2,Chun Huiliu 1,Xi Liao 1, and Meng Yinli 1 1 Zhongyuan University of Technology Textile Institute, Zhengzhou,Postal Code ,The China. E- mail: 2 Collaborative Innovation Center of Textile and Garment Industry, Henan Province, Zhengzhou , China.) Abstract Superhydrophilic/underwater superoleophobic composite films were prepared by electrospinning and spraying with high elastic polyurethane (PU), hydrophilic micro-nano particles β- cyclodextrin (β-cd) and silica (SiO 2 ) as raw materials. The composite films were characterized by SEM and FTIR. The result showed that the micro-nano particles of β-cd/sio 2 were evenly distributed in the composite membrane. The diameter of PU were 300~ 500nm, has very large specific surface area and high porosity (> 80%).Compared with the pure PU nanofibers, the composite film has superhydrophilic/underwater superoleophobic properties after spraying the β-cd/sio 2 particles. When the concentration of β-cd is 20wt% and the SiO 2 is 2wt%, the water contact Angle is the minimum of 5.7 o and the oil contact Angle in water is the maximum of o. This research showed that underwater superoleophobic electrostatic spinning nanofiber membrane was prepared into a wearable sports bandage, which could eliminate body odor by isolating human lipids discharge sweet glands and bacteria. Figure1.Preparation of Electrospun complex film Figure 2. Contact Angle tests Key words: electrostatic spinning, contact angle, superhydrophilic, microspheres layer [1] Ge J, Zong D, Jin Q, et al. Biomimetic and Superwettable Nanofibrous Skins for Highly Efficient Separation of Oil-in-Water Emulsions[J]. Advanced Functional Materials, 2018, 28(10): [2] Jurdi R, Zaidouny L, Abou-Daher M, et al. Electrospun polymer blend with tunable structure for oil-water separation[j]. Journal of Applied Polymer Science, 2018: [3] Chen T, Duan M, Fang S. Fabrication of novel superhydrophilic and underwater superoleophobic Hierarchically structured ceramic membrane and its separation performance of oily wastewater[j]. Ceramics International, 2016, 42(7):

276 Electrospun Polyimide/Metal-organic Framework Nanofibrous Membrane with Superior Thermal Stability for Efficient PM 2.5 Capture Zhimin Hao 1, Juntao Wu 1, Chaolu Wang 1, and Jingang Liu 2 1 Key Laboratory of Bioinspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beihang University, Beijing, , P. R. China. 2 Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing , China. Particulate matter (PM) pollution has serious threaten to human health. Zeolitic imidazolate framework-8 (ZIF-8) is a kind of metal-organic framework (MOF), not only can capture PM 2.5 efficiently but also possesses excellent chemical and thermal stability. In this study, ZIF-8 modified soluble polyimide (PI) nanofibrous membranes were prepared via electrospinning process. As a result, the PI-ZIF membrane shows high PM 2.5 filtration efficiency (up to 96.6±2.9%), superior thermal stability (up to 300 C), good transmittance, excellent mechanical properties and low pressure drop. The prepared PI-ZIF membrane with excellent comprehensive property shows a promising application in PM2.5 capture, especially in harsh conditions. Key Words: Polyimide, ZIF-8, Air filtration, PM2.5, High thermal stability. Acknowledgements: The work is financially supported by the National Natural Science Foundation of China (No ), the National Key Research and Development Program of China (No. 2016YFC ), the Fundamental Research Funds for the Central Universities, and the SRF for ROCS, SEM. [1] Zhang Y, Yuan S, Feng X, et al. Preparation of nanofibrous metal-organic framework filters for efficient air pollution control [J]. J. Am. Chem. Soc., 2016, 138(18), [2] Chen Y, Zhang S, Cao S, et al. Roll-to-Roll Production of Metal-Organic Framework Coatings for Particulate Matter Removal. Adv. Mater., 2017, 29(15),

277 Composite Membrane: an Efficient adsorbent for PM Capture Yao Cheng, Wei Chen* and Yu-Fei Song* State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing , P. R. China. Particulate matter (PM) is a contaminant and cancerogen in air and cause serious health threat to the public. Fabrication of highly efficient and low-resistance membranes for PM capture has attracted wide attention and is currently the focus of scientific community. Layered double hydroxides (LDHs) is a class of anionic lamellar compounds with positive charged layers and intercalated anions, showing great potential for PM capture through electrostatic adsorption. In this study, we introduced a new seeds embedded epitaxial growth (SEEG) strategy for preparation of novel inorganicorganic composite membranes with unique Mortise-Tenon structures. Among the as-prepared membranes, the exhibited excellent removal efficiency for PM10 and PM2.5 of 99.29±0.56%, 99.03±0.82%, respectively, under extreme hazardous air condition with PM > 3000 μg m -3. In particular, this membrane showed outstanding removal efficiency for PM0.3~0.5 of 95.29±1.95%. Moreover, such membrane can be renewed easily and remain the high PM removal efficiency. Environmental friendly as the membranes are, the can be a competitive material for further application in environmental purification. (a-b) The equipments used for PM capture; (c-d) the modified air purifier; (e) after ten times of PM capture; (f) SEM and TEM images of (g) the removal efficiency of PM with different sizes. Key Words: Electrospin, Layered double hydroxides, Polyacrylonitrile, Inorganic-organic composite membranes. Acknowledgements: This research was supported by the National Nature Science Foundation of China (U , U , , ), Beijing Natural Science Foundation ( ) and the Fundamental Research Funds for the Central Universities (XK1802-6, XK1902). [1] M. Shiraiwa, K. Ueda, A. Pozzer, et al. Aerosol Health Effects from Molecular to Global Scales [J]. Environmental Science and Technology, 2017, 51(23), [2] C. T. Gore, W. Chen, Y. -F.Song, et al. Interweaved LDH/PAN nanocomposite films: Application in the design of effective hexavalent chromium adsorption technology [J]. Chemical Engineering Journal, 2016, 284:

278 Cellulose acetate nanofiber membrane with highly efficient for oil/water separation Weiwen Wang, Zhixiang Cui, Junhui Si* College of Materials Science and Engineering, Fujian University of Technology, Fuzhou, China. E- mail: The problem of oily industrial wastewater and seawater pollution is becoming more and more serious, how to efficiently separate the oil/water mixture is still a chanllenge in the world. In this study, the cellulose acetate (CA) were fabricated by electrospinning technology, and then treatment by deacetylation process to obtain the modified CA membranes (m-ca). The results showed that m-ca membranes exhibited the characteristic of superamphiphilic in air (superhydrophilia and superoleophilic), superoleophobic under water and superhydrophilic under oil. The water removal flux and oil removal flux reach up to L/m2 h and L/m2 h, respectively only driven by gravity. The separation efficiency is greater than 99.9%. It has strong anti-pollution and excellent self-cleaning abilities, resulting in powerful reusability. Moreover, the c-ca membrane has the advantages of simple preparation process, abundant resource, renewable, environmentally friendly, cheap price and good chemical stability. Therefore, the c-ca membrane has broad application prospects in chemical plants, textile mills, food industries as well as offshore oil spills field to separate the oil/water mixture. Keywords: superamphiphilic, superhydrophilic underoil, self-cleaning, oil-water separation

279 Electret nanofibrous membrane with enhanced filtration performance and wearing comfortability for face mask Yuyan Yang 1, Xue Yang 1, and Na Wang 1,2 1 Industrial Research Institute of Nonwovens & Technical Textiles, College of Textiles & Clothing, Qingdao University, Qingdao , China. 2 Fiber and Polymer Science Program, Department of Textile Engineering, Chemistry and Science, North Carolina State University, Raleigh, USA. Airborne particulate matter (PM) pollution has become a serious threat to human health, thus it is highly desired for a high-filtration-performance and good-wearing-comfort face mask. Herein, a highly breathable and thermal comfort filter medium consisting of electret polyethersulfone/barium titanate nanofibrous membrane (PES/BaTiO 3 NFM) integrated on a nonwoven polypropylene substrate was developed. Benefiting from the high porosity and optimized injection charge energy, the PES/BaTiO 3 membrane was endowed with a good air permeability of 743 mm s -1, a modest water vapor permeability of 6.24 kg m -2 d -1, and an enhanced charge storage stability. In addition, the electret PES/BaTiO 3 NFM1.5 medium with a low basis weight of 4.32 g m -2 still shows a high filtration efficiency of % and a low pressure drop of 67 Pa after being treated at 200 o C for 45 min, which is better than that of commercial media. Moreover, 3D simulation based on the characters of composite membrane was processed to graphically express the airflow distribution during the filtration process. Significantly, the NFM1.5 with a high infrared (IR) transmittance of 93.4% led to an effective radiative cooling to human body radiation. This multifunctional fibrous medium design may provide new insights into the development of environmental adaptive protection materials. Key Words: Electrospinning, Breathable nanofibrous membrane, Thermal radiation, Air filtration Acknowledgements: This work is supported by the National Natural Science Foundation of China (No ) and China Postdoctoral Science Foundation (No: 2018M642609). [1] Bian, Y., Zhang, L., Chen, C. High-temperature particulate matter filtration with resilient yttriastabilized ZrO 2 nanofiber sponge [J]. Small, 2018, 14(19): [2] Tseng, H., Wu, J., Lin, Y., et al. Superoleophilic and superhydrophobic carbon membranes for high quantity and quality separation of trace water-in-oil emulsions [J]. Journal of Membrane Science, 2018, 559(1):

280 Conjugated Microporous Polymer (CMP) Particles Based PAN Nanofibrous Membrane for High-efficiency Particulate Matter Filtration Jiyoung Lee 1 and Il-Doo Kim 1 1 Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea. * Corresponding Author: Along with the rapid economic growth and increased urbanization, airborne particulate matter (PM) pollution has become a serious environmental issue that affect ecosystems and damage public health. 1 Strenuous efforts have been made to develop filter materials with high capture efficiency toward fine particles and low air resistance. 2 Among the available materials, fibrous membranes fabricated by electrospinning of polymers such as polyurethane and polyacrylonitrile have been considered as promising air filter materials because of the integrated features of ultrathin one dimensional nanostructure, high porosity, and ease of large-scale production. However, the filtration efficiency and the air permeability of currently developed fibrous materials are still not reaching satisfying levels due to the dense structure of the fiber membranes and low electrostatic force toward fine particles. Herein, we introduce electrospun polyacrylonitrile (PAN)/conjugated microporous polymer (CMP) nanofibers (CMP-NF) which provide perfect platform for PM removal owing to the partial surface charge of the electron delocalized π-conjugated polymer backbone and microporous structure to efficiently exploit sieving and interception effect toward fine particles. The CMP-NF were readily prepared by electrospinning of polyacrylonitrile(pan) and CMP particle mixtures where the CMP particles were synthesized via an acid-catalyzed in-situ cyclization reaction as followed literature. 3 In particular, the seven fused benzene rings of 1,5,9-triamine-triphenylene (TATP) in CMP particles provide ideal molecular arrangement to induce negative surface charge, thus giving high electrostatic force toward PM. In addition, the high specific surface area (860 m 2 g -1 ) and microporous structure (< 2 nm) of CMP particles efficiently improve filtration efficiency toward PM while retaining low pressure drop. We believe that our strategy of embedding CMPs into 1D-nanofiber membranes will open up new possibilities for a range of various filtration and separation applications. Key Words: Conjugated microporous polymers (CMPs), Particulate matters (PMs) removal, 1Dnanofibers, electrospinning) [1] He M., Ichinose T, Kobayashi M. et al. Differences in Allergic Inflammatory Responses Between Urban PM2.5 and Fine Particle Derived from Desert-Dust in Murine Lungs. [J]. Toxicol. Appl. Pharmacol. 2016, 297, [2] W. T. Koo, J. S. Jang, S. Qiao, W. T. Hwang, G. Jha, R. M. Penner, and I. D. Kim. Hierarchical Metal Organic Framework Assembled Membrane Filter for Efficient Removal of Particulate Matter [J]. ACS Appl. Mater. Interfaces 2018, 10(23): [3] J. Lee, O. Buyucakir, T-w. Kwon, and A. Coskun. Energy Band-Gap Engineering of Conjugated Microporous Polymers via Acidity-Dependent In-situ Cyclization [J]. J. Am. Chem. Soc. 2018, 140 (35):

281 High Performance Electrospun Polyphenylquinoxaline Ultrafine Fibrous Membranes for Separation of Highly Alkaline Red Mud Chenyu Guo, Lin Qi, Mengge Huangfu, Jingang Liu * Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing , China. Red mud represents a class of hazardous by-products produced in the process of alumina smelting, with a ph value higher than 10.0 at room temperature, which are great of harm to the environment [1]. In various studies of comprehensive utilization of red mud, filtration with filter membrane is undoubtedly one of the most effective processes. Polyphenylquinoxaline (PPQ) is thought to be the most hydrolysis-resistant heteroaromatic polymer [2], and the good comprehensive properties make PPQs the best candidate materials as filtration membranes for red mud slurry. In this study, a series of PPQ ultrafine non-woven fibrous membranes designed for the separation of highly alkaline red mud slurry have been successfully prepared via the electrospinning procedure with the PPQ solutions as the starting materials. For this purpose, various organo-soluble PPQ resins were first synthesized via the one-step high temperature polycondensation procedure from the aromatic ether-bridged bis( -diketone) and bis(o-diamine) monomers. The high-molecular-weight PPQ resins were dissolved in N-methyl-2- pyrrolidone (NMP) to afford the PPQ electrospinning solution. The derived PPQ ultrafine non-woven fibrous membranes exhibited good thermal stability with the 5% weight loss temperatures (T 5% ) higher than o C and glass transition temperatures (T g ) in the range of o C, respectively. The PPQ membranes were used as the filtration medium for the separation of highly alkaline red mud slurry. During the separation process, the PPQ filter membranes exhibited excellent stability in the aqueous alkaline circumstance of red mud slurry either at room temperature (ph=13.0 at 21.5 o C) or at higher processing temperature (ph=12.1 at 60.5 o C). Red mud powder was highly efficiently separated from the slurry via the PPQ filter membranes and easily stripped from the membrane, as shown in Fig.1. Fig.1. Separation of red mud from slurry using the electrospun PPQ filter membranes. (a) 21.5 o C (ph=13.0) filtration; (b) 60.5 o C (ph=12.1) filtration; (c) separation of red mud and water; (d) separation of red mud from the PPQ membrane Key Words: polyphenylquinoxaline, electrospinning, red mud, alkaline stability, thermal stability Acknowledgements: Financial support from the Fundamental Research Funds of China University of Geosciences, Beijing (No ) is gratefully acknowledged. [1] Kumar S, Kumar R, Bandopadhyay A. Innovative Methodologies for the Utilisation of Wastes from Metallurgical and Allied Industries [J]. Resources, Conservation and Recycling, 2006, 48(4): [2] Li C, Li Z, Liu J, et al. Synthesis and Characterization of Organo-Soluble Thioether-bridged Polyphenylquinoxalines with Ultra-high Refractive Indices and Low Birefringences [J]. Polymer, 2010, 51(17):

282 PVA/PEI crosslinked electrospun nanofibers with embedded La(OH) 3 nanorod for high flux phosphorus selective absorption Shiyang Li 1, Xiangfeng Huang 1, Jia Liu 1,Lijun Lu 1, Kaiming Peng 1 1 College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, Ministry of Education Key Laboratory of Yangtze River Water Environment, Shanghai Institute of Pollution Control and Ecological Security, Tongji University, Shanghai , People's Republic of China. The endogenous contamination has become the chronic disease of the aquatic ecological environment recovery for pre-anthropogenic affected waterbody. Especially, phosphorus, which is the limiting element to trigger eutrophication, is easily attached on sediments and hard to be removed from waterbody by phase changing. Using electrospun method to synthesizing absorbents could simply avoid the issues mentioned above 1-4. Electrospun method could fabricate nanosized fiber and distribute active core with homogeneous dispersion, and stabilize it in nanofiber matrixes through impregnating process. In this study, A Polyvinyl Alcohol (PVA) and polyethyleneimine (PEI) crosslinked nanofiber membrane were synthesized and La(OH) 3 were loading through the impregnating process. The La(OH) 3 loaded nanofiber was synthesized through (1) La(NO 3 ) 3 precursor solution was mixed with PVA/PEI for electrospun and (2) Glutaraldehyde (GA) crosslinked it and La(OH) 3 impregnated by alkali treatment. The La(OH) 3 loaded nanofiber played a role in catching phosphate ions in an aqueous solution by the oxidation, reduction, and ion-exchange of adsorbed La 3+ on the nanofiber from La(OH) 3 to LaPO 4, and enabled remarkable phosphate adsorption capacity of the nanofiber (ca. 165mg P/g La) at the range of ca. ph 2 6. Our strategy might be the most feasible method to efficiently lower the phosphorus concentration in lakes or rivers owing to the easy. Key Words: Phosphorus removal, high flux, water-based formula, crosslinked nanofiber [1] Yongtao Y, Yuncheng X Bing, et al. Recent development in electrospun polymer fiber and their composites with shape memory property: a review[j]. Pigment & Resin Technology 2018, 47 (1), [2] Kadam V. V, Wang L, Padhye R, Electrospun nanofibre materials to filter air pollutants A review[j]. Journal of Industrial Textiles 2018, 47 (8), [3] Balzer C, Armstrong M, Shan B, et al. Modeling Nanoparticle Dispersion in Electrospun Nanofibers[J]. Langmuir 2018, 34 (4),

283 Breathable and asymmetrically superwettable Janus membrane with robust oil-fouling resistance for durable membrane distillation Zhigao Zhu, Lingling Zhong, Fuyi Cui, Wei Wang State Key Laboratory of Urban Water Resource and Environment (SKLUWRE), School of Environment, Harbin Institute of Technology, Harbin , P. R. China. Membrane distillation (MD) is a membrane based thermally driven process, in which water molecules in the hot feed vaporize at the liquid/membrane interface and diffuse across a hydrophobic porous membrane to the cold distillate. 1 Significantly, MD can make full use of waste heat to generate high-quality water and is not restricted by the water quality conditions, thus is emerged as a viable technology for wastewater treatment or the desalination of seawater and brackish water. 2 However, durability and fouling are two critical factors that directly affect membrane durability during the treatment of challenging feedwaters such as wastewater or polluted seawater and brine. 3 Herein, a highly breathable membrane integrating an asymmetrically superwettable Janus skin and a hydrophobic nanofibrous membrane (NFM) was developed via sequential electrospinning and electrospraying for application in membrane distillation (MD). The electrosprayed asymmetrically superwettable Janus skin composed of lotus-leaf-like nano/microstructured nanofilaments exhibited an intriguing underwater superoleophobicity of 164 and an in-air superhydrophobicity of 166, thereby providing a robust resistance to membrane fouling with high flux. The newly developed membrane with an ultrathin Janus skin layer, high porosity and interconnected pore structure displayed a high water flux of over 25 L m -2 h -1, a robust oil resistance and an excellent durability in direct contact MD (ΔT=40 C) during the treatment of oil-in-saline water emulsion (1000 ppm oil). The present development can thus endow MD with the ability to desalinate challenging water matrices with complex compositions. Significantly, the sequential electrospraying process utilized in the construction of the Janus skin is expected to be applicable to a wide range of other selective separations. Key Words: Electrospinning, asymmetrically superwettable membrane, Janus membrane, membrane distillation Acknowledgements: The authors gratefully acknowledge the National Natural Science Foundation of China (No ), National Science and Technology Major Project (No. 2017ZX ). Reference [1] Z. Zhu, Y. Liu, H. Hou, et al. Dual-Bioinspired Design for Constructing Membranes with Superhydrophobicity for Direct Contact Membrane Distillation [J]. Environ. Sci. Technol, 2018, 52(5): [2] K. Lingbin, Engineering Problems of a New Thermal Seawater Desalination Technology [J]. J. Energy Power Eng. 2017, 11, [3] Z. Wang, S. Lin. Membrane fouling and wetting in membrane distillation and their mitigation by novel membranes with special wettability[j]. Water Res, 2017, 112,

284 Electrospun regenerated cellulose nanofiber Shuo Zeng 1, Zhao Wang 1, Hao Fong 2 1 Department of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, China, 2 South Dakota School of Mines and Technology, P.O.Box , South Dakota, United States Electrospun nanofiber membranes (ENMs) have demonstrated promising applications for water purification primarily due to high water flux and low degree of fouling. To make regenerated cellulose (RC) ENMs for ultrafiltration applications, atom transfer radical polymerization (ATRP) was studied to graft polymer chains onto the surface of RC nanofibers; specifically, monomers of 2-hydroxyethyl methacrylate (HEMA) and sodium acrylate (AAS) were selected for surface-grafting water-insoluble and water-soluble polymer chains onto RC nanofibers, respectively. With prolonging of the ATRP reaction time, the resulting surface-modified RC ENMs had reduced pore sizes. The water-insoluble poly(hema) chains coated the surface of RC nanofibers to make the fibers thicker, thus decreasing the membrane pore size and reducing permeability. On the other hand, the water-soluble poly(aas) chains did not coat the surface of RC nanofibers; instead, they partially filled the pores to form gel-like structures, which served to decrease the eff ective pore size, while still providing elevated permeability. The surface-modified RC ENMs were subsequently explored for ultrafiltration of ~ 40 nm nanoparticles and ~10 nm bovine serum albumin (BSA) molecules from water. The results indicated that the HEMA-modified RC membranes could reject/remove more than 95% of the nanoparticles while they could not reject any BSA molecules; in comparison, the AASmodified RC membranes had complete rejection of the nanoparticles and could even reject ~58% of the BSA molecules. Key Words: electrospinning, nanofiber membrane, regenerated cellulose, ATRP, ultrafiltration [1] Zhao Y H, Wee K H, Bai R. A Novel Electrolyte-Responsive Membrane with Tunable Permeation Selectivity for Protein Purification[J]. ACS Applied Materials & Interfaces, 2010, 2(1): [2] Hansson S, Emma Östmark, Carlmark A, et al. ARGET ATRP for Versatile Grafting of Cellulose Using Various Monomers[J]. ACS Applied Materials & Interfaces, 2009, 1(11):

285 High adsorption pearl-necklace-like composite membrane based on metalorganic framework for heavy metal ion removal Xuebin Hou a, Min Zhao a,yajun Chen a, Yibing Cai a, Fenglin Huang a, Qufu Wei a * a Key Laboratory of Eco-textiles, Ministry of Education, Jiangnan University, Wuxi, Jiangsu , People's Republic of China. Abstract The zeolitic imidazolate framework-67 (ZIF-67) based pearl-necklace-like composite membranes were prepared by in situ inter-grown on the surface of 2-Methylimidazole/cellulose acetate (MIM/CA) electrospun nanofibers for the first time. The incubation time of ZIF-67 had a significant influence on the structures and properties of the composites. And with an approximate saturation of ZIF-67 nanocrystals, the integrated composites achieved a much higher surface area of m²g -1 which was as dozens of times as that of pure MIM/CA electrospun nanofibers (6.9 m²g -1 ). In addition, the composites performed a high Cu(II) and Cr(VI) adsorption of 18.9 mg g -1 and 14.5 mg g -1, respectively. The adsorption data were well fitted with the pseudo-second-order kinetics. Therefore, the fabricated MOF-composite membrane with special pearl-necklace-like was a promising environmental material for removing heavy metal ions from water. Key words: electrospun; metal-organic frameworks; composite membranes; adsorption : [1] W.T. Koo, S.J. Choi, S.J. Kim, et al., Heterogeneous Sensitization of Metal-Organic Framework Driven Oxide Complex Catalysts on an Oxide Nanofiber Scaffold Toward Superior Gas Sensors, J. Am. Chem. Soc. 138 (2016) [2] D. Nagaraju, D.G. Bhagat, R. Banerjee, U.K. Kharul, In situ growth of metal-organic frameworks on a porous ultrafiltration membrane for gas separation, J. Mater. Chem. A. 1 (2013) 8828.

286 Fe-doped TiO 2 electrospun nanofibrous mats for textile wastewater treatment Yuhui, Yang 1, Peijin Cui-Tian 1,, Zhiyue Wu 1, Yang Zhou 1 1, 2*, and Shili Xiao 1 School of Textile Science and Engineering, Wuhan Textile University, Wuhan , P. R. China. E- mail: 2 Key Laboratory of Green Processing and Functional Textile of New Textile Materials, Ministry of Education, Wuhan Textile University, Wuhan , P. R. China. Titanium dioxide (TiO 2 ) has drawn much attention in the environmental remediation because of its advantages of low cost, high stability and high photocatalytic activity. TiO 2 can form electron-hole pairs under the illumination of near-uv light, which can be used to the catalytic oxidation of pollutants. However, the high degree of recombination of photogenerated electrons and holes makes TiO 2 exhibit a limited photocatalytic activity [1]. The addition of metal ions as dopants to reduce the recombination rate is a promising method to improve the photocatalytic activity of TiO 2 [2]. In this study, we combined zerovalent iron nanoparticle with TiO 2 to produce iron-doped TiO 2 nanofibrous mats for improved treatment of textile wastewater. Polyacrylonitrile (PAN) nanofibrous mats were firstly electrospun. Subsequently, PAN nanofibrous mats were immersed in the dopamine solution containing TiO 2 nanoparticles (~20 nm) to produce TiO 2 -loaded PAN nanofibers. The TiO 2 -loaded PAN nanofibrous mats were assembled with PAA solution and then acted as nanoreactors to complex ferric iron. Fe-doped TiO 2 nanofibrous mats were finally formed using NaBH 4 reduction. Fe-doped TiO 2 nanofibers were characterized using scanning electrospun microspcopy, X-ray energy-dispersive spectroscopy detector, and Fourier transform infrared spectroscopy. The photocatalytic degradation capability of Fe-doped TiO 2 nanofibrous mats towards organic dye (methyl blue) was quantitatively evaluated using UV-vis spectrophotometer. The results showed that a complete decoloration of methyl blue was obtained within 35 min. Moreover, Fe-doped TiO 2 nanofibrous mats were reusable for three times without sacrificing its decoloration capability. Fig. 1. SEM image of the Fe-doped TiO2 nanofibers (a), UV-vis spectra of methyl blue solution in the presence of Fe-doped TiO2 nanofibrous mats (first time) (b) and the photograph of methyl blue solution treated with Fe-doped TiO 2 nanofibrous mats for the first, second, and third time (c). Key Words: Fe-doped TiO 2, nanofiber, polyacrylic nanofiber, textile wastewater Acknowledgements: This work was financially supported by the National Natural Science Foundation of China ( ) and the Science Foundation of Wuhan Textile University (153034). [1] Ganesh K. Parshetti, Ruey-an Doong. Synergistic effect of nickel ions on the coupled dechlorination of richloroethylene and 2,4-dichlorophenol by Fe/TiO 2 nanocomposites in the presence of UV light under anoxic conditions [J]. Water Research, 2011, 45: [2] Ruey-an Doong, Sue-min Chang, Chia-wei Tsai. Enhanced photoactivity of Cu-deposited titanate nanotubes for removal of bisphenol A [J]. Applied Catalysis B: Environmental, 2013, 129:

Biomaterials: Production, Processing and Application

Biomaterials: Production, Processing and Application AITEX infoday - New Textiles. Research and Innovation in the Textile-Clothing- Technical Textiles Industry Brussels, 31st March 2009 Silk-Based Biomaterials: Production, Processing and Application Dr.

More information

BNG 331 Cell-Tissue Material Interactions. Biomaterial Surfaces

BNG 331 Cell-Tissue Material Interactions. Biomaterial Surfaces BNG 331 Cell-Tissue Material Interactions Biomaterial Surfaces Course update Updated syllabus Homework 4 due today LBL 5 Friday Schedule for today: Chapter 8 Biomaterial surface characterization Surface

More information

How To Make A Vascular Graft

How To Make A Vascular Graft LCL-GRAFT TM - Innovative Large and Small Caliber Vascular Grafts for Coronary Bypass and Peripheral Vascular Surgery. A. Perets 1, M. Li 1, P. Uttayarat 1, P. Pimton 1, A. Wu 2, R. J. Levy 3, R. J. Composto

More information

Biotechnology. Srivatsan Kidambi, Ph.D.

Biotechnology. Srivatsan Kidambi, Ph.D. Stem Stem Cell Cell Engineering-What, Biology and it Application Why, How?? to Biotechnology Srivatsan Kidambi, Ph.D. Assistant Professor Department of Chemical & Biomolecular Engineering University of

More information

Formation of Oriented Fibers Using Injection of PEO Solutions inside Electric Fields Defined by Two Parallel Suspended Electrodes

Formation of Oriented Fibers Using Injection of PEO Solutions inside Electric Fields Defined by Two Parallel Suspended Electrodes 06 (43)-AF:Modelo-AF 8/20/11 6:41 AM Page 122 Formation of Oriented Fibers Using Injection of PEO Solutions inside Electric Fields Defined by Two Parallel Suspended R. Furlan 1, J. A. M. Rosado 2, A. N.

More information

Biomaterials in tissue engineering

Biomaterials in tissue engineering Biomaterials in tissue engineering S. Swaminathan Director Centre for Nanotechnology & Advanced Biomaterials School of Chemical & Biotechnology SASTRA University Thanjavur 613 401 Tamil Nadu Page 1 of

More information

Chemical Engineering - CHEN

Chemical Engineering - CHEN Auburn University 1 Chemical Engineering - CHEN Courses CHEN 2100 PRINCIPLES OF CHEMICAL ENGINEERING (4) LEC. 3. LAB. 3. Pr. (CHEM 1110 or CHEM 1117 or CHEM 1030) and (MATH 1610 or MATH 1613 or MATH 1617

More information

THE RESORBABLE MATRIX. Relax. Remaix. The membrane of choice for reliable bone and tissue regeneration

THE RESORBABLE MATRIX. Relax. Remaix. The membrane of choice for reliable bone and tissue regeneration THE RESORBABLE MATRIX Relax. Remaix. The membrane of choice for reliable bone and tissue regeneration Remaix properties Remaix is a resorbable barrier membrane for use in guided bone regeneration (GBR)

More information

Safe Nano Design Molecule Manufacturing Market

Safe Nano Design Molecule Manufacturing Market August 14 16, 212 College of Nanoscale Science & Engineering (CNSE) of the University at Albany National Institute for Occupational Safety and Health (NIOSH) Prevention through Design Program Safe Nano

More information

Assoc. Prof. Dr. M. Aylin DELİORMANLI

Assoc. Prof. Dr. M. Aylin DELİORMANLI Assoc. Prof. Dr. M. Aylin DELİORMANLI EDUCATION Degree University Department / Program Undergrad Ege University Chemical Engineering 99 99 M.S. Izmir Institute of Tech. Materials Science and Engineering

More information

HyStem. Hydrogels CELLULAR MATRICES FOR TRANSLATIONAL RESEARCH. esibio.com

HyStem. Hydrogels CELLULAR MATRICES FOR TRANSLATIONAL RESEARCH. esibio.com HyStem Hydrogels CELLULAR MATRICES FOR TRANSLATIONAL RESEARCH HyStem Hydrogel Extracellular Matrices Chemically-defined For use in 2D and 3D formats in vitro and in vivo applications Customizable for many

More information

TOTAL HIP REPLACEMENT FOR A LIFETIME: THE CEMENTLESS METAL ON METAL RECONSTRUCTION

TOTAL HIP REPLACEMENT FOR A LIFETIME: THE CEMENTLESS METAL ON METAL RECONSTRUCTION Richard A. Sweet, M.D. Louisville Orthopaedic Clinic Louisville, KY TOTAL HIP REPLACEMENT FOR A LIFETIME: THE CEMENTLESS METAL ON METAL RECONSTRUCTION INTRODUCTION Total hip replacement surgery (THR) has

More information

Scout Vessel Guard. A hydrogel membrane with exceptional handling characteristics.

Scout Vessel Guard. A hydrogel membrane with exceptional handling characteristics. . A hydrogel membrane with exceptional handling characteristics. Pliable Permanent Pore size < 0.08μm Instruments and implants approved by the AO Foundation . A hydrogel membrane with exceptional handling

More information

Dr. Jim Steuber, PE, Department of Mechanical Engineering, jsteuber@atu.edu, 479-968-0202

Dr. Jim Steuber, PE, Department of Mechanical Engineering, jsteuber@atu.edu, 479-968-0202 A. Title Page Design, construction and characterization of electrospinning apparatus for nanofibers Dr. Jim Steuber, PE, Department of Mechanical Engineering, jsteuber@atu.edu, 479-968-0202 B. Restatement

More information

LifeNet Health Presented by James Clagett, PhD., Chief Science Officer LifeNet Health - The Best Keep Secret in Regenerative Medicine

LifeNet Health Presented by James Clagett, PhD., Chief Science Officer LifeNet Health - The Best Keep Secret in Regenerative Medicine Presented by James Clagett, PhD., Chief Science Officer - The Best Keep Secret in Regenerative Medicine Corporate Headquarters Virginia Beach, VA Who is? helps save lives and restore health for thousands

More information

Supporting Information. Phosphorus-, nitrogen- and carbon- containing polyelectrolyte complex:

Supporting Information. Phosphorus-, nitrogen- and carbon- containing polyelectrolyte complex: Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2014 S1 Supporting Information Phosphorus-, nitrogen- and carbon- containing polyelectrolyte complex:

More information

VISCOSE FIBRES WITH NEW FUNCTIONAL QUALITIES

VISCOSE FIBRES WITH NEW FUNCTIONAL QUALITIES VISCOSE FIBRES WITH NEW FUNCTIONAL QUALITIES Walter Roggenstein Kelheim Fibres GmbH, Regensburger Str. 109, 93309 Kelheim, Germany Phone: (+49) 9441 99-489; Fax: (+49) 9441 99-1489; Email: walter.roggenstein@kelheim-fibres.com

More information

ENERGY DISSIPATION IN CONDUCTIVE POLYMERIC FIBER BUNDLES: SIMULATION EFFORT

ENERGY DISSIPATION IN CONDUCTIVE POLYMERIC FIBER BUNDLES: SIMULATION EFFORT ENERGY DISSIPATION IN CONDUCTIVE POLYMERIC FIBER BUNDLES: SIMULATION EFFORT NSF Summer Undergraduate Fellowship in Sensor Technologies Dorci Lee Torres-Velázquez (Mathematics) - University of Puerto Rico

More information

Strategy for Functional Material Development in FUJIFILM

Strategy for Functional Material Development in FUJIFILM 証券コード 4901 Strategy for Functional Material Development in FUJIFILM - Global competency strategy for business innovation in Functional Material Industry - Sep. 24, 2013 FUJIFILM Corporation Development

More information

Technology Breakthrough in Spinal Implants (Technical Insights)

Technology Breakthrough in Spinal Implants (Technical Insights) Technology Breakthrough in Spinal Implants (Technical Insights) Biomaterial innovations is a growth factor for spinal implant market June 2014 Table of Contents Section Page Number Executive Summary 4

More information

well foresight studies opportunities for regenerative medicine in the netherlands royal netherlands academy of arts and sciences

well foresight studies opportunities for regenerative medicine in the netherlands royal netherlands academy of arts and sciences well underway opportunities for regenerative medicine in the netherlands royal netherlands academy of arts and sciences foresight studies 5. conclusions and recommendations Scientific research in regenerative

More information

Overview of the Research Programs of School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University

Overview of the Research Programs of School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University Overview of the Research Programs of School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University Mission To bridge and integrate engineering technology and medical sciences

More information

MISCIBILITY AND INTERACTIONS IN CHITOSAN AND POLYACRYLAMIDE MIXTURES

MISCIBILITY AND INTERACTIONS IN CHITOSAN AND POLYACRYLAMIDE MIXTURES MISCIBILITY AND INTERACTIONS IN CHITOSAN AND POLYACRYLAMIDE MIXTURES Katarzyna Lewandowska Faculty of Chemistry Nicolaus Copernicus University, ul. Gagarina 7, 87-100 Toruń, Poland e-mail: reol@chem.umk.pl

More information

Section B: Epithelial Tissue 1. Where are epithelial tissues found within the body? 2. What are the functions of the epithelial tissues?

Section B: Epithelial Tissue 1. Where are epithelial tissues found within the body? 2. What are the functions of the epithelial tissues? Tissue worksheet Name Section A: Intro to Histology Cells are the smallest units of life. In complex organisms, cells group together with one another based on similar structure and function to form tissues.

More information

MANUFACTURE OF CONTROLLED DRUG DELIVERY DEVICE OF POLYCAPROLACTONE BY SELECTIVE LASER SINTERING ABSTRACT

MANUFACTURE OF CONTROLLED DRUG DELIVERY DEVICE OF POLYCAPROLACTONE BY SELECTIVE LASER SINTERING ABSTRACT MANUFACTURE OF CONTROLLED DRUG DELIVERY DEVICE OF POLYCAPROLACTONE BY SELECTIVE LASER SINTERING P. Klauss 1*, G. V. Salmoria 1, M. Souza 1, L. A. Kanis 2 1* Laboratory CIMJECT, Federal University of Santa

More information

Applications and Benefits of Multi-Walled Carbon Nanotubes (MWCNT)

Applications and Benefits of Multi-Walled Carbon Nanotubes (MWCNT) I Applications and Benefits of Multi-Walled Carbon Nanotubes (MWCNT) Table of Content 1 Introduction...1 2 Improved Properties...1 3 Potential Applications...1 3.1 Current / short-term applications...3

More information

Electrospinning introduction

Electrospinning introduction Electrospinning introduction Introduction to the problematic of electrospinning technology, basic terminology. Introduction of physical principles of electrospinning technology (Taylor cone, Rayleigh instability,

More information

Developing an Orientation-graded Nanomatrix to Promote Axonal Regeneration and Functional Recovery in Spinal Cord Injury (SCI)

Developing an Orientation-graded Nanomatrix to Promote Axonal Regeneration and Functional Recovery in Spinal Cord Injury (SCI) Developing an Orientation-graded Nanomatrix to Promote Axonal Regeneration and Functional Recovery in Spinal Cord Injury (SCI) Vinoy Thomas, Ph. D. Research Assist. Professor Dept. of Materials Sci. &

More information

Biomedical Engineering Graduate Program in METU / ANKARA

Biomedical Engineering Graduate Program in METU / ANKARA Biomedical Engineering Graduate Program in METU / ANKARA Faculty of Engineering Institute of Applied Mathematics Informatics Institute Faculty of Arts and Sciences Electrical and Electronics and Engineering

More information

Electrospun jets launched from polymeric bubbles

Electrospun jets launched from polymeric bubbles Electrospun jets launched from polymeric bubbles J.S. Varabhas a, S. Tripatanasuwan b, G.G. Chase a,*, D.H. Reneker b a Department of Chemical and Biomolecular Engineering, The University of Akron, Akron,

More information

Nanotechnology for Food Processing and Packaging

Nanotechnology for Food Processing and Packaging Nanotechnology for Food Processing and Packaging John D. Floros Professor & Head Department of Food Science Pennsylvania State University www.foodscience.psu.edu Information Sources Pennsylvania State

More information

Ikerbasque Research Professor, Centre for Cooperative Research in Biomaterials, CIC. biomagune, 20009, San Sebastián, Spain

Ikerbasque Research Professor, Centre for Cooperative Research in Biomaterials, CIC. biomagune, 20009, San Sebastián, Spain Luis M. Liz- Marzán Ikerbasque Research Professor, Centre for Cooperative Research in Biomaterials, CIC. biomagune, 20009, San Sebastián, Spain Current Position: L UIS M. LIZ- MARZÁN Education: Bachelor

More information

Nomex KD Technology. DuPont TM. DuPont s Heritage in Hot Gas Filtration Application. For over 4 decades, a filter media made of Nomex

Nomex KD Technology. DuPont TM. DuPont s Heritage in Hot Gas Filtration Application. For over 4 decades, a filter media made of Nomex DuPont s Heritage in Hot Gas Filtration Application For over 4 decades, a filter media made of Nomex brand fibre has been considered as the state of the art product in typical filtration applications such

More information

KINETIC MOLECULAR THEORY OF MATTER

KINETIC MOLECULAR THEORY OF MATTER KINETIC MOLECULAR THEORY OF MATTER The kinetic-molecular theory is based on the idea that particles of matter are always in motion. The theory can be used to explain the properties of solids, liquids,

More information

The application of nanotechnology in the treatment of Rheumatoid Arthritis and Osteoarthritis. By Aniketa Khushu PASS WITH MERIT

The application of nanotechnology in the treatment of Rheumatoid Arthritis and Osteoarthritis. By Aniketa Khushu PASS WITH MERIT The application of nanotechnology in the treatment of Rheumatoid Arthritis and Osteoarthritis By Aniketa Khushu PASS WITH MERIT Research Paper based on Pathology Lectures at Medlink 2010 1 Abstract: Introduction:

More information

Nanoparticle Deposition on Packaging Materials by the Liquid Flame Spray

Nanoparticle Deposition on Packaging Materials by the Liquid Flame Spray Nanoparticle Deposition on Packaging Materials by the Liquid Flame Spray Hannu Teisala a, Mikko Tuominen a, Mikko Aromaa b, Jyrki M. Mäkelä b, Milena Stepien c, Jarkko J. Saarinen c, Martti Toivakka c

More information

Additive Verfahren mit biologischen Materialien

Additive Verfahren mit biologischen Materialien 3D Druck und Health Tech Additive Verfahren mit biologischen Materialien Dr. Markus Rimann Zürcher Hochschule für Angewandte Wissenschaften (ZHAW) Fachgruppe Tissue Engineering Background: 3D Cell Culture

More information

Chemical Basis of Life Module A Anchor 2

Chemical Basis of Life Module A Anchor 2 Chemical Basis of Life Module A Anchor 2 Key Concepts: - Water is a polar molecule. Therefore, it is able to form multiple hydrogen bonds, which account for many of its special properties. - Water s polarity

More information

BIOMEDICAL ENGINEERING NEURO-ONCOLOGY

BIOMEDICAL ENGINEERING NEURO-ONCOLOGY BIOMEDICAL ENGINEERING NEURO-ONCOLOGY SCAFFOLDING 10 MICRONS THIN NEUROSURGERY DEPLOYMENT THROUGH CATHETERS BRAIN EXVADERS A NOVEL BIOENGINEERING SOLUTION AIMED AT PEDIATRIC BRAIN TUMORS COULD SOMEDAY

More information

Keystone Review Practice Test Module A Cells and Cell Processes. 1. Which characteristic is shared by all prokaryotes and eukaryotes?

Keystone Review Practice Test Module A Cells and Cell Processes. 1. Which characteristic is shared by all prokaryotes and eukaryotes? Keystone Review Practice Test Module A Cells and Cell Processes 1. Which characteristic is shared by all prokaryotes and eukaryotes? a. Ability to store hereditary information b. Use of organelles to control

More information

Absorption of Drugs. Transport of a drug from the GI tract

Absorption of Drugs. Transport of a drug from the GI tract Absorption of Drugs Absorption is the transfer of a drug from its site of administration to the bloodstream. The rate and efficiency of absorption depend on the route of administration. For IV delivery,

More information

SBO3 acntb s. NANOFORCE Next generation nano-engineered Polymer-Steel/CNT Hybrids. Lightweight and multi-functional. aligned Carbon Nanotube bundles

SBO3 acntb s. NANOFORCE Next generation nano-engineered Polymer-Steel/CNT Hybrids. Lightweight and multi-functional. aligned Carbon Nanotube bundles NANOFORCE Next generation nano-engineered Polymer-Steel/CNT Hybrids SBO3 acntb s Lightweight and multi-functional aligned Carbon Nanotube bundles Jin Won (Maria) Seo User Committee Meeting Nanoforce, 7

More information

Performance of Carbon-PTFE Electrodes and PTFE Separators in Electrochemical Double Layer Capacitors (EDLCs)

Performance of Carbon-PTFE Electrodes and PTFE Separators in Electrochemical Double Layer Capacitors (EDLCs) Performance of Carbon-PTFE Electrodes and PTFE Separators in Electrochemical Double Layer Capacitors (EDLCs) David Zuckerbrod, Robert Sassa, Marianne Szabo, Meagan Mizenko Abstract: W. L. Gore & Associates

More information

Kick-off meeting. Barcelona, 3-5 March 2014 08.04.2014 1

Kick-off meeting. Barcelona, 3-5 March 2014 08.04.2014 1 Kick-off meeting Barcelona, 3-5 March 2014 08.04.2014 1 UCL- overview Known as 'London's Global University', University College London employs 4,078 academic research staff in over 50 departments and institutes.

More information

An Overview of Cells and Cell Research

An Overview of Cells and Cell Research An Overview of Cells and Cell Research 1 An Overview of Cells and Cell Research Chapter Outline Model Species and Cell types Cell components Tools of Cell Biology Model Species E. Coli: simplest organism

More information

Usage of Carbon Nanotubes in Scanning Probe Microscopes as Probe. Keywords: Carbon Nanotube, Scanning Probe Microscope

Usage of Carbon Nanotubes in Scanning Probe Microscopes as Probe. Keywords: Carbon Nanotube, Scanning Probe Microscope International Journal of Arts and Sciences 3(1): 18-26 (2009) CD-ROM. ISSN: 1944-6934 InternationalJournal.org Usage of Carbon Nanotubes in Scanning Probe Microscopes as Probe Bedri Onur Kucukyildirim,

More information

Strong bone for beautiful teeth Patient Information I Bone reconstruction with Geistlich Bio-Oss and Geistlich Bio-Gide

Strong bone for beautiful teeth Patient Information I Bone reconstruction with Geistlich Bio-Oss and Geistlich Bio-Gide Strong bone for beautiful teeth Patient Information I Bone reconstruction with Geistlich Bio-Oss and Geistlich Bio-Gide Contents Smiling is the most beautiful way to show your teeth 3 What are the causes

More information

Computational Nanoscience of Soft Matter

Computational Nanoscience of Soft Matter ChE/MSE 557 Computational Nanoscience of Soft Matter Fall 2006 Instructor: Professor Sharon C. Glotzer Class meets: Tues 3:00-6:00 Location: Room 3336 BD, Duderstadt Center Room 3336 AC, Duderstadt Center

More information

Biotechnical Engineering PLTW Scope and Sequence Year at a Glance First Semester

Biotechnical Engineering PLTW Scope and Sequence Year at a Glance First Semester Biotechnical PLTW Scope and Sequence Year at a Glance First Semester Three Weeks 1 st 3 weeks 2 nd 3 weeks 3 rd 3 weeks 4 th 3 weeks 5 th 3 weeks 6 th 3 weeks Topics/ Concepts I. Safety and Documentation

More information

North Bergen School District Benchmarks

North Bergen School District Benchmarks Grade: 10,11, and 12 Subject: Anatomy and Physiology First Marking Period Define anatomy and physiology, and describe various subspecialties of each discipline. Describe the five basic functions of living

More information

Rapid Prototyping and Development of Microfluidic and BioMEMS Devices

Rapid Prototyping and Development of Microfluidic and BioMEMS Devices Rapid Prototyping and Development of Microfluidic and BioMEMS Devices J. Sasserath and D. Fries Intelligent Micro Patterning System Solutions, LLC St. Petersburg, Florida (T) 727-522-0334 (F) 727-522-3896

More information

Professor John Varcoe (Department of Chemistry, University of Surrey, UK) Plamen Atanassov

Professor John Varcoe (Department of Chemistry, University of Surrey, UK) Plamen Atanassov Electronic Supplementary Material (ESI) for Energy & Environmental Science. This journal is The Royal Society of Chemistry 2014 Professor John Varcoe (Department of Chemistry, University of Surrey, UK)

More information

Fluidic Assembly and Interfacial Science of Nano- Microstructured Systems for Electronics and Medicine

Fluidic Assembly and Interfacial Science of Nano- Microstructured Systems for Electronics and Medicine Fluidic Assembly and Interfacial Science of Nano- Microstructured Systems for Electronics and Medicine David H. Gracias Assistant Professor Department of Chemical and Biomolecular Engineering and Department

More information

Softwell. Petrisoft. Collagen. Ultrasoft. 25 kpa. 8 kpa. Easy Coat. 1 kpa. Softview. Hydrogel-coated wells for cell culture. Non-activated 0.

Softwell. Petrisoft. Collagen. Ultrasoft. 25 kpa. 8 kpa. Easy Coat. 1 kpa. Softview. Hydrogel-coated wells for cell culture. Non-activated 0. Softwell Hydrogel-coated wells for cell culture Non-activated 0.2 kpa 25 kpa Collagen 8 kpa Easy Coat Petrisoft Ultrasoft Softview 1 kpa Introducing Softwell It s like a Petri dish. Only to a cell, it

More information

On the Mean Flow Pore Size Distribution of Microfiber and Nanofiber Webs

On the Mean Flow Pore Size Distribution of Microfiber and Nanofiber Webs ORIGINAL PAPER/PEER-REVIEWED On the Mean Flow Pore Size Distribution of Microfiber and Nanofiber Webs By Dr. Norman Lifshutz, Senior Research Fellow, Hollingsworth & Vose Co. Abstract A nonwoven fibrous

More information

Basic Properties and Application of Auto Enamels

Basic Properties and Application of Auto Enamels Basic Properties and Application of Auto Enamels Composition of Ceramic Automotive Glass Enamels Ceramic automotive glass colours are glass enamels that fire on to the glass during the bending process

More information

XCM Biologic Tissue Matrix. Regenerative matrix for reinforcement and repair of soft tissue.

XCM Biologic Tissue Matrix. Regenerative matrix for reinforcement and repair of soft tissue. XCM Biologic Tissue Matrix. Regenerative matrix for reinforcement and repair of soft tissue. Hydrated, ready-to-use Allows for cellular infiltration Strength without crosslinking XCM Biologic Tissue Matrix

More information

Pulsed laser deposition of organic materials

Pulsed laser deposition of organic materials Pulsed laser deposition of organic materials PhD theses Gabriella Kecskeméti Department of Optics and Quantum Electronics University of Szeged Supervisor: Dr. Béla Hopp senior research fellow Department

More information

Silicone products for tissues

Silicone products for tissues Creating tomorrow s solutions Silicone products for tissues The paper used in tissues must meet tough demands. It must be odorless or have a fresh fragrance. It must be fluffy, soft and gentle on the skin,

More information

Micro- and Nanoengineering of Biomaterials for Healthcare Applications

Micro- and Nanoengineering of Biomaterials for Healthcare Applications Micro- and Nanoengineering of Biomaterials for Healthcare Applications The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation As

More information

Exploratory Brief on Nanomedicine or the Application of Nanotechnology in Human Healthcare

Exploratory Brief on Nanomedicine or the Application of Nanotechnology in Human Healthcare Exploratory Brief on Nanomedicine or the Application of Nanotechnology in Human Healthcare Paula Corabian, Dagmara Chojecki March 6, 2012 Objectives Provincial Health Technology Assessment (HTA) Program

More information

Supporting information

Supporting information Supporting information Ultrafast room-temperature NH 3 sensing with positively-gated reduced graphene oxide field-effect transistors Ganhua Lu 1, Kehan Yu 1, Leonidas E. Ocola 2, and Junhong Chen 1 * 1

More information

Use of Carbon Nanoparticles for the Flexible Circuits Industry

Use of Carbon Nanoparticles for the Flexible Circuits Industry Use of Carbon Nanoparticles for the Flexible Circuits Industry Ying (Judy) Ding, Rich Retallick MacDermid, Inc. Waterbury, Connecticut Abstract FPC (Flexible Printed Circuit) has been growing tremendously

More information

THE INFLUENCE OF SHAPE AND SPATIAL DISTRIBUTION OF METAL PARTICLES ON THE THERMAL CONDUCTIVITY OF METAL-POLYMER COMPOSITES

THE INFLUENCE OF SHAPE AND SPATIAL DISTRIBUTION OF METAL PARTICLES ON THE THERMAL CONDUCTIVITY OF METAL-POLYMER COMPOSITES International Journal of Mechanical Engineering and Technology (IJMET) Volume 6, Issue 12, Dec 2015, pp. 30-35, Article ID: IJMET_06_12_004 Available online at http://www.iaeme.com/ijmet/issues.asp?jtype=ijmet&vtype=6&itype=12

More information

CHEMICAL SENSORS 1. DEFINITION

CHEMICAL SENSORS 1. DEFINITION CHEMICAL SENSORS 1. DEFINITION A chemical sensor is a device that transforms chemical information (composition, presence of a particular element or ion, concentration, chemical activity, partial pressure

More information

2011 Annual Report T H E NANOTECHNOLOGY I N S T I T U T E

2011 Annual Report T H E NANOTECHNOLOGY I N S T I T U T E 2011 Annual Report T H E NANOTECHNOLOGY TM I N S T I T U T E The Nanotechnology Institute The Nanotechnology Institute (NTI) is southeastern Pennsylvania s first multi-institutional partnership created

More information

3D Cell Culture mimsys G

3D Cell Culture mimsys G 3D Cell Culture mimsys G xeno-free & nutrient permeable hydrogel for 3D cell culture mimsys G is a xeno-free and non-immunogenic, easy to handle hydrogel for cell encapsulation in 3D experiments in vitro

More information

Figure 1. A schematic representation of a PEO coatings: mushroom conformation on the left hand side and brush conformation on the right hand side.

Figure 1. A schematic representation of a PEO coatings: mushroom conformation on the left hand side and brush conformation on the right hand side. 7 General discussion Chapter 7 Microbial adhesion onto the surface of medical implants, like hip prostheses and urinary catheters, followed by biofilm formation, often leads to infections on these implants.

More information

UTILIZATION of PLASMA ACTIVATED WATER in Biotechnology, Pharmacology and Medicine. JSC TECHNOSYSTEM-ECO Moscow, Russia April, 2009

UTILIZATION of PLASMA ACTIVATED WATER in Biotechnology, Pharmacology and Medicine. JSC TECHNOSYSTEM-ECO Moscow, Russia April, 2009 UTILIZATION of PLASMA ACTIVATED WATER in Biotechnology, Pharmacology and Medicine JSC TECHNOSYSTEM-ECO Moscow, Russia April, 2009 METHOD of WATER ACTIVATION with PLASMA of GAS DISCHARGE ANODE VACUUM WATER

More information

chronos BOne VOid Filler Beta-Tricalcium Phosphate (b-tcp) bone graft substitute

chronos BOne VOid Filler Beta-Tricalcium Phosphate (b-tcp) bone graft substitute chronos BOne VOid Filler Beta-Tricalcium Phosphate (b-tcp) bone graft substitute chronos Bone Void Filler Osteoconductive Resorbable Synthetic chronos Granules and Preforms are synthetic, porous, osteoconductive,

More information

FINAL REPORT For Japan-Korea Joint Research Project AREA

FINAL REPORT For Japan-Korea Joint Research Project AREA FINAL REPORT For Japan-Korea Joint Research Project AREA 1. Mathematics & Physics 2. Chemistry & Material Science 3. Biology 4. Informatics & Mechatronics 5. Geo-Science & Space Science 6. Medical Science

More information

Unit 1 Higher Human Biology Summary Notes

Unit 1 Higher Human Biology Summary Notes Unit 1 Higher Human Biology Summary Notes a. Cells tissues organs body systems Division of labour occurs in multicellular organisms (rather than each cell carrying out every function) Most cells become

More information

Artur Bartkowiak. Centre for Bioimmobilisation and Innovative Packaging Materials, West Pomeranian University of Technology Szczecin

Artur Bartkowiak. Centre for Bioimmobilisation and Innovative Packaging Materials, West Pomeranian University of Technology Szczecin Artur Bartkowiak DIRECTOR FOR THE CENTRE Centre for Bioimmobilisation and Innovative Packaging Materials, West Pomeranian University of Technology Szczecin http://cbimo.zut.edu.pl/en BILATERAL MEETINGS

More information

AMBERLITE IRP64 Pharmaceutical Grade Cation Exchange Resin (Polacrilex Resin)

AMBERLITE IRP64 Pharmaceutical Grade Cation Exchange Resin (Polacrilex Resin) AMBERLITE IRP64 Pharmaceutical Grade Cation Exchange Resin (Polacrilex Resin) Description AMBERLITE IRP64 [1] resin is an insoluble, weakly acidic, hydrogen form, cation exchange resin supplied as a dry,

More information

OPTIMIZING OF THERMAL EVAPORATION PROCESS COMPARED TO MAGNETRON SPUTTERING FOR FABRICATION OF TITANIA QUANTUM DOTS

OPTIMIZING OF THERMAL EVAPORATION PROCESS COMPARED TO MAGNETRON SPUTTERING FOR FABRICATION OF TITANIA QUANTUM DOTS OPTIMIZING OF THERMAL EVAPORATION PROCESS COMPARED TO MAGNETRON SPUTTERING FOR FABRICATION OF TITANIA QUANTUM DOTS Vojtěch SVATOŠ 1, Jana DRBOHLAVOVÁ 1, Marian MÁRIK 1, Jan PEKÁREK 1, Jana CHOMOCKÁ 1,

More information

What is nanotoxicology?

What is nanotoxicology? What is nanotoxicology? How to estimate the potential hazard related to nanoparticles? Dissemination report October 2008 DR-225 200810-5 Project ID NMP2-CT-2005-515843 An European Integrated Project Supported

More information

chemicals > transported from outside to in > waste products created > they need to be removed

chemicals > transported from outside to in > waste products created > they need to be removed 1 Transport systems chemicals > transported from outside to in > waste products created > they need to be removed Simple organisms Diffusion the free movement of particles in a liquid or a gas down a concentration

More information

MICRO DROPLET GENERATION TECHNOLOGY

MICRO DROPLET GENERATION TECHNOLOGY MICRO DROPLET GENERATION TECHNOLOGY Micro-droplet Generation Technology Micro-droplet Generation System Semiconductor Wafer Cleaning Precision Coating Emulsion Twin-Fluid Nozzle System www.hshi-tech.co.kr

More information

Thomas J. Webster, Weldon School of Biomedical Engineering and School of Materials Engineering, Purdue University, West Lafayette, IN 47907

Thomas J. Webster, Weldon School of Biomedical Engineering and School of Materials Engineering, Purdue University, West Lafayette, IN 47907 Nanotechnology to Benefit Tissue Engineering Thomas J. Webster, Weldon School of Biomedical Engineering and School of Materials Engineering, Purdue University, West Lafayette, IN 47907 Introduction Nanobiotechnology

More information

Advantages Of A New And Advanced Nanofiber Coating Technology For Filtration Media Compared to The Electrospinning Process

Advantages Of A New And Advanced Nanofiber Coating Technology For Filtration Media Compared to The Electrospinning Process Advantages Of A New And Advanced Nanofiber Coating Technology For Filtration Media Compared to The Electrospinning Process John Wertz Immo Schnieders Abstract Research and development of nanofibers has

More information

h e l p s y o u C O N T R O L

h e l p s y o u C O N T R O L contamination analysis for compound semiconductors ANALYTICAL SERVICES B u r i e d d e f e c t s, E v a n s A n a l y t i c a l g r o u p h e l p s y o u C O N T R O L C O N T A M I N A T I O N Contamination

More information

AAGPs TM Anti-Aging Glyco Peptides. Enhancing Cell, Tissue and Organ Integrity Molecular and biological attributes of lead AAGP molecule

AAGPs TM Anti-Aging Glyco Peptides. Enhancing Cell, Tissue and Organ Integrity Molecular and biological attributes of lead AAGP molecule AAGPs TM Anti-Aging Glyco Peptides Enhancing Cell, Tissue and Organ Integrity Molecular and biological attributes of lead AAGP molecule 1 Acknowledgements This presentation was prepared by Dr. Samer Hussein

More information

BIOMEDICAL ENGINEERING UNDERGRADUATE CURRICULUM

BIOMEDICAL ENGINEERING UNDERGRADUATE CURRICULUM BIOMEDICAL ENGINEERING UNDERGRADUATE CURRICULUM 2014-2015 (as of 4/26/2013) This program is accredited by the Engineering Accreditation Commission of ABET, http://www.abet.org. Undergraduate Program Mission

More information

Developments in Glass Yarns and Fabric Constructions

Developments in Glass Yarns and Fabric Constructions feature Developments in Glass Yarns and Fabric Constructions by Alun Morgan Isola Group Europe Glass fibres are nothing new; the ancient Egyptians reportedly drew coarse fibres from heat softened glass.

More information

CHAPTER 1 INTRODUCTION

CHAPTER 1 INTRODUCTION CHAPTER 1 INTRODUCTION 1.1 Research Background Diabetes mellitus is a disease in which the body cannot produce sufficient insulin in their pancreas to adequately control the level of glucose in their blood

More information

M.Sc. in Nano Technology with specialisation in Nano Biotechnology

M.Sc. in Nano Technology with specialisation in Nano Biotechnology M.Sc. in Nano Technology with specialisation in Nano Biotechnology Nanotechnology is all about designing, fabricating and controlling materials, components and machinery with dimensions on the nanoscale,

More information

History & Fast Facts. Academic Programs. Research & Innovation. Education

History & Fast Facts. Academic Programs. Research & Innovation. Education History & Fast Facts Academic Programs Faculty Student & Education Research & Innovation Established in 1898, Peking University was originally named the Imperial University of Peking. It was the first

More information

Tailored bioabsorbable implants and scaffolds for biomedical and tissue engineering applications

Tailored bioabsorbable implants and scaffolds for biomedical and tissue engineering applications Tailored bioabsorbable implants and scaffolds for biomedical and tissue engineering applications Minna Kellomäki Professor, Dr Tech, FBSE BioMediTech and Department of Electronics and Communications Engineering

More information

Six major functions of membrane proteins: Transport Enzymatic activity

Six major functions of membrane proteins: Transport Enzymatic activity CH 7 Membranes Cellular Membranes Phospholipids are the most abundant lipid in the plasma membrane. Phospholipids are amphipathic molecules, containing hydrophobic and hydrophilic regions. The fluid mosaic

More information

BIOACTIVE COATINGS ON 316L STAINLESS STEEL IMPLANTS

BIOACTIVE COATINGS ON 316L STAINLESS STEEL IMPLANTS Trends Biomater. Artif. Organs. Vol. 17(2) pp 43-47 (2004) http//www.sbaoi.org BIOACTIVE COATINGS ON 316L STAINLESS STEEL IMPLANTS N. Ramesh Babu*,+, Sushant Manwatkar*, K. Prasada Rao* and T. S. Sampath

More information

Zero Width Glass Cutting with CO 2 Laser

Zero Width Glass Cutting with CO 2 Laser Zero Width Glass Cutting with CO 2 Laser Mohammed Naeem GSI Group, Laser Division Cosford Lane, Swift Valley Rugby mnaeem@gsig.com Introduction Laser cutting of glass in not a novel technique, excellent

More information

Study on Wet Etching of AAO Template

Study on Wet Etching of AAO Template Study on Wet Etching of AAO Template Guofeng Hu, Haiming Zhang, Wenwen Di & Tingting Zhao School of Science, Tianjin Polytechnic University, Tianjin 300160, China E-mail: hugf2009@163.com Abstract The

More information

Undergraduate Biomedical Engineering Curriculum University of North Carolina at Chapel Hill, 2014-2015

Undergraduate Biomedical Engineering Curriculum University of North Carolina at Chapel Hill, 2014-2015 Undergraduate Biomedical Engineering Curriculum University of North Carolina at Chapel Hill, 2014-2015 First two years Fall: BMME 101 Frontiers of Biomedical Engineering (strongly recommended but not required;

More information

S YN T H E T I C C A N C E L LO U S B O N E

S YN T H E T I C C A N C E L LO U S B O N E S YN T H E T I C C A N C E L LO U S B O N E CELLPLEX TCP Graft is a synthetic cancellous scaffold that provides an optimum environment for cellular infiltration. Composed of tricalcium phosphate, the scaffold

More information

Graduate and Postdoctoral Affairs School of Biomedical Sciences College of Medicine. Graduate Certificate. Metabolic & Nutritional Medicine

Graduate and Postdoctoral Affairs School of Biomedical Sciences College of Medicine. Graduate Certificate. Metabolic & Nutritional Medicine Graduate and Postdoctoral Affairs School of Biomedical Sciences College of Medicine Graduate Certificate in Metabolic & Nutritional Medicine Graduate Certificate Metabolic & Nutritional Medicine Purpose

More information

TECHNOLOGICAL INNOVATION FOR CORONARY STENTS Francesco Migliavacca

TECHNOLOGICAL INNOVATION FOR CORONARY STENTS Francesco Migliavacca LABORATORY OF BIOLOGICAL STRUCTURE MECHANICS www.labsmech.polimi.it TECHNOLOGICAL INNOVATION FOR CORONARY STENTS Francesco Migliavacca Erice, 1 maggio 2015 International School of Cardiac Surgery Introduction

More information

Compartmentalization of the Cell. Objectives. Recommended Reading. Professor Alfred Cuschieri. Department of Anatomy University of Malta

Compartmentalization of the Cell. Objectives. Recommended Reading. Professor Alfred Cuschieri. Department of Anatomy University of Malta Compartmentalization of the Cell Professor Alfred Cuschieri Department of Anatomy University of Malta Objectives By the end of this session the student should be able to: 1. Identify the different organelles

More information

Biotechnical Engineering (BE) Course Description

Biotechnical Engineering (BE) Course Description Biotechnical Engineering (BE) Course Description The major focus of the Biotechnical Engineering TM (BE) course is to expose students to the diverse fields of biotechnology including biomedical engineering,

More information

4. Which carbohydrate would you find as part of a molecule of RNA? a. Galactose b. Deoxyribose c. Ribose d. Glucose

4. Which carbohydrate would you find as part of a molecule of RNA? a. Galactose b. Deoxyribose c. Ribose d. Glucose 1. How is a polymer formed from multiple monomers? a. From the growth of the chain of carbon atoms b. By the removal of an OH group and a hydrogen atom c. By the addition of an OH group and a hydrogen

More information

Raven and Conductex Products for Specialty Applications

Raven and Conductex Products for Specialty Applications Raven and Conductex Products for Specialty Applications e e FUNDAMENTAL PROPERTIES OF CARBON BLACK A carbon black s application performance is determined by its fundamental properties and the level of

More information