An update in Mesothelioma and Thymoma Management
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1 An update in Mesothelioma and Thymoma Management ASCO 2014 update Khalid Alsaleh King Saud University FRCPC, FACP, MSc
2 Mesothelioma
3 Outline
4 Outline Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
5 Mesothelioma Treatment Algorithm Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
6 P/D v. EPP: Less Surgery May Be Better Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
7 Evaluation of Mesothelioma in a Phase III Study of ALIMTA with CISplatin: 3 Month Survival Advantage Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
8 Rare Responses with 2nd Line Chemotherapy Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
9 Outline Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
10 Three Common Somatic Aberrations in Mesothelioma: CDKN2A, NF2, BAP1 Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
11 Outline Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
12 Partial List of Ongoing Clinical Trials Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
13 mtor/pi3k Signaling Pathway Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
14 Response to Dual PI3K/mTOR Inhibition with GDC0980 Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
15 FAK Inhibition Effective with Merlin Loss Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
16 Randomized Phase II Study of Defactinib Maintenance (ASCO #TPS7611) Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
17 CTLA-4 Therapy in Mesothelioma Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
18 Ongoing Randomized Phase II Tremelimumab Trial Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
19 Mesothelin as a Therapeutic Target Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
20 CRS-207 Stimulates Cellular Immunity to Mesothelin (ASCO #7532) Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
21 Response to Anti-Mesothelin Immunotoxin SS1P and Immune Suppression Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
22 Conclusions/Future Directions Presented By Marjorie Zauderer at 2014 ASCO Annual Meeting
23 Thymoma
24 Outline/Learning Objectives<br />
25 Thymic Epithelial Tumors
26 Thymomas - General Characteristics
27 Incidence
28 The incidence of Thymic Malignancy is increasing
29 PubMed Literature Search Thymoma<br />January 1989-December 2009 (n=1991 papers)
30 ITMIG
31 International Thymic Malignancies Interest Group (ITMIG) Mission
32 ITMIG Membership
33 ITMIG Status
34 Slide 14
35 Slide 15
36 ITMIG Retrospective Data-Map
37 Slide 17
38 Slide 18
39 Slide 19
40 Slide 20
41 Staging
42 Slide 22
43 Prognostic Value of Masaoka Stage
44 Prognostic Value of Masoaka Stage
45 ITMIG-IASLC Stage Classification Project
46 ITMIG-IASLC Stage Classification Proposal
47 ITMIG Node Map
48 Histological Classification
49 Slide 30
50 WHO 2004 histological classification of TETs
51 WHO classification: survival implications
52 Histologic Classification
53 Molecular Biology
54 Slide 35
55 Slide 36
56 Genetic Alterations
57 Slide 38
58 Gene Signatures
59 Slide 40
60 Slide 41
61 Gene signatures
62 Treatment
63 Thymoma - 5-year survival
64 Treatment - Early Stage Thymic Malignancy
65 Treatment - Locally Advanced
66 Slide 47
67 Thymoma - surgery
68 Five year Survival: Stage III/IV
69 Slide 50
70 Thymoma - radiotherapy
71 Slide 52
72 Prospective Chemotherapy Trials
73 Treatment
74 Thymic Malignancies Treatment Summary
75 Challenges in research
76 Targeted Therapies
77 Genetic Abnormalities in Thymic Malignancies
78 Targeted therapies in Thymic Malignancies
79 Sunitinib in TETs: Best response to treatment
80 Custom Trial
81 Slide 62
82 Slide 63
83 Epigenetic Gene mutations in TC
84 Slide 65
85 Conclusions
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Thymus Cancer. This reference summary will help you better understand what thymus cancer is and what treatment options are available.
Thymus Cancer Introduction Thymus cancer is a rare cancer. It starts in the small organ that lies in the upper chest under the breastbone. The thymus makes white blood cells that protect the body against