LASIK/PRK following previous eye Surgery

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1 AAO San Francisco 2009 LASIK/PRK following previous eye Surgery A. John Kanellopoulos, MD Associate Clinical Professor, NYU Medical School Director: Laservision.gr Eye Institute, Athens, Greece 1

2 Indications Penetrating keratoplasy Pseudophakia Glaucoma Sx Radial / Astigmatic keratotomy Retinal Surgery PRK/ Lasik Bioptics Following CXL 2

3 LASIK Following Radial Keratotomy Special Concerns Treat epithelial linclusions i and wound gapes prior to LASIK (re-suture if ness.) Careful surface marking Carefully handle flap to avoid tearing RK along incisionsi i Thicker flaps Enhancements difficult Higher incidence of DLK? 3

4 LASIK following Radial Keratotomy PERK Study: 43% of eyes had a 1D hyperopic shift at 10 years Following LASIK 91% improvement or no change in BCVA 1 Following LASIK no loss of 2 lines in BCVA 2 1 Attia. Journal of Cataract t and Refractive Surgery, Lindstrom. Ophthalmology,

5 LASIK following Radial Keratotomy Hyperopic shift/ Visual fluctuation may continue Ineffective for irregular astigmatism (except with wavefront-guided and/or topo-guided) 5

6 50 y/o male, s/p RK for about 8 UCVA 20/40-, 20/40 in USSR /25 (8/10) /25- (7/10) Significant night glare (dec) 6

7 Pre-op 7

8 Post-opop 8

9 46 y/o male 10 years s/p RK for x? and subsequent hyperopic shift 9

10 46 y/o male 10 years s/p RK for x? and subsequent hyperopic shift sc: 20/80 diplopia Rx x 17 gives 20/25 LASIK with the Moria M2 and the Allegretto-wave Post-op 3 months: Sc 20/30! x 40 20/

11 LASIK Following Penetrating Keratoplasty 39-70% of PK s are within 3D of emmetropia Mean cylinder following PK is 4-5 D Following LASIK 100% are within 3 D emmetropia 1 91% of eyes BCVA remained the same or improved 1 Contact lens remains standard of care 1 Donnenfeld. Ophthalmology,

12 12

13 13

14 14

15 15

16 LASIK Following Penetrating Keratoplasty Special Concerns Avoid graft-host interface Flap adherence 5 minutes Increased postoperative corticosteriods i Endothelial dysfunction and flap slippage 1 Keratoconus and progressive ectasia 1 Donnenfeld. ASCRS,

17 34 y/o male 2 years s/p Therapeutic PK for a CL-related ulcer Good cell counts: top= OD unaffected eye Bottom= OS eye with PK Rx x 56 with the Allegretto-wave Post-op 3 months: Sc 20/30! x 50 20/

18 LASIK Following Cataract Surgery No significant concerns with PC/IOL Careful with endothelial dysfunction around phaco wound site (flap slippage, poor adhesion)? PRK with AC/IOL Future of cataract surgery 18

19 LASIK and the Glaucoma Patient Absolute Contraindications Filtering/Valve Surgery -End stage disease Significant ON damage and/or Visual Field Loss Uncontrolled Glaucoma More than 2 Medications 19

20 20

21 LASIK and the Glaucoma Patient Special Concerns Epithelial Sloughing: Discontinue topical meds pre-op Oral CAIs Nerve Fiber Layer Analysis(HRT, GDx) Post-operative IOP Measurement Mean Decrease in IOPi is 4.3 mm Hg 1 Beware of low IOP and progressive ON damage (interface fluid-maloney Ophathalmology2002) 1 Danasoury. Journal ofrefractive Surgery,

22 LASIK Following Retinal Detachment Pre-LASIK vitreoretinal consultation Avoid LASIK in high buckles-risk of poor suction/ irregular flap Treatment of asymptomatic holes controversial il Avoid silicone oil eyes 22

23 LASIK after Previous PRK Central keratometry/ Orbscan Consider Epithelial hyperplasia (If suspected plan for thicker flap) Increased postoperative steroids 23

24 LASIK after Previous LASIK Relift flap if possible (unless limited by thin cornea) Ud Undercorrect consecutive ametropia 1 1 Jacobs. Journal of cataract and refractive surgery,

25 LASIK after Previous LASIK New flap should be larger and deeper than the original flap or narrower and thinner (the same MK will cut a thinner consecutive flap on a thinner cornea) Posterior flap ablation when residual stromal bed not adequate (not possible with flying-spot excimers) Personal preference: minimum i cornea thickness> 400nm 35<K s<

26 Artisan/Verisyse 26

27 OD Bioptics 6 months postop 20/

28 WG enhancement-poor result Pre: Post: 28

29 Same pt other eye RMSH improved from 1,2 to 0.36 (!) LCS improved from C3 to C7 (!) 29

30 Q value adjustment 30

31 Re-treatments: 1-Q value calculated at 20 degrees 2-Possible on almost 100% of cases 3-Little risk of making worse 4-Less tissue demands 31

32 RESULT at 6 months Post-op op Q values: OD: +1.2 to OS: +1.5 to +0.1 CS to from 5 to 7 at 12 degrees 32

33 Topography guided 33

34 Enlarging myopic optical zone: Initially -10, 505µ LASIK: 4,5mmOZ,, 125µ flap M2->plano ^BCVA 2 lines, but night halostopo-guided Tx to enlarge OZ to6mm and adjusting Q value to - 1,46Initially halos gone, RE

35 Post-trauma irregular astigmatism Old K perf, s/p CE, IOL,s/p LASIK for now -1, irregularbcva 20/40+Topo-guided, Q adjustment to -0.3 Postop: UCVA 20/30, BCVA 20/

36 Post-surgery irregular astigmatism Complicated CE-Aphakia-Artisan IOL-in an old LASIK pt P BCVA 20/60 Postop UCVA 20/

37 Centering optical zone-hyperopia Initially: , plasik: UCVA 20/40 BCVA 20/25 ptopog: plano UCVA 20/

38 Enlarging optical zone-rk 10 year post-rk, Post-LASIK: +2,50-1,50Cyl, debilitating night vision. P topo-guided marked improvement 38

39 Enlarging optical zone-hyperopia S/p LASIK for +4.50, now and night vision down C3, s/p topo-guided CS=C7 39

40 Post-keratitis irregular astigmatism Patient t with old severe Cornea ulcer and paracentral flattening irregular cyl UCVA 20/200 to 20/25 BSCVA from 20/40- to 20/

41 Re-centering OZ, smoothing irregularities (Loss of K sliver in recuts) 41

42 Topo-guided epi LASIK with the Moria EpiK and Wavelight Eye-Q laser improve cyl 6 months 20/20-, cyl 42

43 How do we select topo- or waveguided? 43

44 Topo-wavefronts OD OS PRE POST 44

45 Clinical Case Treatment Results Corneal ltopography pre- and post-enhancement t Pre-enhancement enhancement Post-enhancement Difference 45

46 Patient 2 75y/o male s/p PRK in the Pseudophakic OS has now significant haze, irregular hyperopic astigmatism UCVA 20/200 BSCVA 20/50 with @ Significant superficial and anterior stromal haze exists He is referred dfor a cornea graft 46 A. John Kannellopoulos, M.D., PhD, WaveLight Global Ambassador, Athens, Greece & New York, USA 46

47 Pre-operative Topography: Topolyzer 47 A. John Kannellopoulos, M.D., PhD, WaveLight Global Ambassador, Athens, Greece & New York, USA 47

48 Pre-operative Topography: Oculyzer 48 A. John Kannellopoulos, M.D., PhD, WaveLight Global Ambassador, Athens, Greece & New York, USA 48

49 Pre-operative Wavefront Map Non available K haze 49 A. John Kannellopoulos, M.D., PhD, WaveLight Global Ambassador, Athens, Greece & New York, USA 49

50 50 A. John Kannellopoulos, M.D., PhD, WaveLight Global Ambassador, Athens, Greece & New York, USA 50

51 Wavefront Ablation Profile Non available 51 A. John Kannellopoulos, M.D., PhD, WaveLight Global Ambassador, Athens, Greece & New York, USA 51

52 Topography Ablation Profile 52 A. John Kannellopoulos, M.D., PhD, WaveLight Global Ambassador, Athens, Greece & New York, USA 52

53 OcuLink Ablation Profile 53 53

54 Wavefront Optimized TM Ablation Profile 54 54

55 Treatment: 50 microns PTK at 7mm OZ Topolyzer-guided treatment (due to the haze a nd irregularity was anticipated to be more accurate than the Oculyzer-guided Tx UVA CCL 3 mw/cm % riboflavin 30 minutes 55 A. John Kannellopoulos, M.D., PhD, WaveLight Global Ambassador, Athens, Greece & New York, USA 55

56 At 3 m UCVA 20/40, : 20/

57 Summary-Custom Q Q adjustment may be an effective and tissue sparing primary treatment and re-treatment approach It may not change unwanted Zernickes as in wavefront-guided It appears to improve the most predictable factor in night vision problems: Cornea asphericity or spherical aberration C12 It appears to optimise mesopic and scotopic visual quality 57

58 DSEAK with anterior scarring treated t with PTK/PRK

59 Post PTK/PRK

60 Anterior K clarity before and after

61 Topo-guided PRK Kanellopoulos MD

62 J Ophthalmol hh ljune 07: CXL and then topo-guided d PRK in postwww.brilliantvision.com LASIK ectasia

63

64 J Cornea August

65 Over the last 7 years we have treated over 800 cases of KCN and ectasia with CXL J Cornea August 2007 CXL followed 6 months later by a partial tprk Kanellopoulos MD 65

66 Kanellopoulos MD 66

67 Conclusion With intelligent pre-operative selection and surgical planning, LASIK and PRK can be invaluable in the visual rehabilitation of patients following previous ocular surgery. 67

68 Thank you Thank you Kanellopoulos MD 68

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